CN104173705B - Chinese medicine composition of the turbid refreshing lung of a kind ofization and preparation method thereof - Google Patents
Chinese medicine composition of the turbid refreshing lung of a kind ofization and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to Chinese medicine composition of the turbid refreshing lung of a kind ofization and preparation method thereof, the Chinese medicine composition is made up of the Chinese medicine of following parts by weight：Balloonflower root, licorice, cordate houttuynia, Exocarpium Citri Rubrum, Radix Angelicae Sinensis and bulb of thunberg fritillary.By it is experimentally confirmed that Chinese medicine composition provided by the invention can be used for the disease for treating turbid phlegm obstructing lung, effect is better than prior art.
Description
Technical field
The present invention relates to the field of Chinese medicines, and in particular to Chinese medicine composition of the turbid refreshing lung of a kind ofization and preparation method thereof.
Background technology
Phlegm is a kind of sticky pathological product of its liquid, once a kind of secondary pathogenic factor can be turned into again by being formed.Phlegm system is dirty
Turbid heresy, it is turbid to be commonly referred to as phlegm.
Theory of traditional Chinese medical science thinks that phlegm is due to that human-body viscera function is not normal, aqueous dysbolism and the pathological product that is formed, phlegm
Generation it is how relevant with lung, spleen, kidney.Said if any " phlegm coming from spleen ", " lung being reservoir of phlegm ".Phlegm is turbid stagnant in throat then office
Portion itches, and triggers cough more than.A surname that phlegm choke road (trachea-bronchial epithelial cell etc.) can more influence lung qi leads to respectful drop, and cause cough,
The disease such as asthma, uncomfortable in chest.Thus turbid phlegm obstructing lung is that lung system respectively demonstrate,proves (equivalent to the various diseases of modern medicine respiratory system) generation
An important factor for aggravating.
Lung is " canopy ", the gas of main the whole body, in the form of Xuan Fasu is reduced to basic exercise.Lung is salubrious, for exhalation foul smell,
The normal performance of the physiological functions such as spreading gas Tianjin plays a crucial role.
Change turbid refreshing lung and refer to and dispel a kind of turbid therapy of phlegm in lung, stay in lung suitable for phlegm is turbid, the turbid resistance of phlegm for the air flue that is jammed
Lung is demonstrate,proved, it is clinical coughing, coughing up phlegm, panting, uncomfortable in chest, gurgling weith sputum etc. for main performance, be common in bronchitis, pneumonia bronchus expands
, a variety of diseases such as asthma, chronic pharyngitis.
Phlegm turbid " storage " not only influences airway patency in lung, and can often turn into virus, bacterial growth and the base of breeding,
Source of generation is demonstrate,proved as inflammation.The haze weather especially occurred extensively in the numerous big or middle cities in the whole nation in recent years, already as one
Individual the reason for individually triggering cough, coughing up phlegm.Pathogenic microorganisms can be adhered in haze on molecule, directly can be inhaled by mouth and nose
Enter and enter lung, turbid must not use up of the phlegm in air flue is removed, then run into inspiring for exopathogen, causes virus, bacterium to be enlivened, inflammation card
Acute attack, cause the recurrence of diseases of pulmonary system.With the passing of time acute bronchitis such as equivalent to lung system " cough " is not cured, develop into
Chronic bronchitis.Therefore, previously there is the people of chronic respiratory disease, the haze sky state of an illness is easier to recur or aggravate [Liang De
It is great, the cough caused analysis of king's Zhe .150 example haze skies and countermeasure [J] contemporary Chinese medicinal applications, 2014,14 (8)：73-
74]。
Phlegm is turbid to be lied prostrate in lung long, can also be injured lungs in itself, be caused the physiological function of lung to be badly damaged, the lung is concerned with QI of the whole body,
Lung qi fictitious pole, the heart, kidney can be further injured, influence " the main water of kidney ", " kidney governing inspiration " and " the main blood of the heart ", the work(of " the heart controlling mental and emotional activities "
Can, there are the diseases such as feeling of distension and oppression over the chest, dyspnea and cough with excessive sputum, palpitaition, edema, this display turbid phlegm obstructing lung, be not with the passing of time cured, be further converted to
" the lung-distension ", equivalent to modern medicine obstructive emphysema, cor pulmonale etc..Respectively card also has the similar rule changed for other lung systems
Rule, so, turbid phlegm obstructing lung is an important factor for various lung systems demonstrate,prove (namely various respiratory diseases) occurrence and development.Therefore, how quickly
The heresy that phlegm is turbid in lung is effectively eliminated, is one of important measures of disease such as clinical prevention respiratory system, cardio-cerebrovascular.
For the treatment method that phlegm is turbid, modern medicine is treated using sal-ammoniac, bromhexine, carbocisteine etc. more, its
Mechanism is by reducing bronchorrhea secretion, the viscosity reduced or the viscous phlegm of dissolving, so as to eliminating the phlegm, expectoration.But these medicines
It is stimulate stomach linings more, often cause reflexive Nausea and vomiting etc. to be had a stomach upset sense.
The often type diagnosis and treatment based on an overall analysis of the illness and the patient's condition such as point cold, wind, heat, wet of Chinese traditional treatment turbid phlegm obstructing lung.There is resolving sputum expectoration in the market
The Chinese patent drug of effect, to treat based on phlegm heat symptom-complex and mostly syrup or sugaring granule, therapeutic effect is not ideal enough.This be because
It is " tender to hide " for lung, mistake bitter cold or sweet, Lung Qi obstraction can be caused, disorder of qi, be not only unfavorable for sputum discharge, also have hardship
In cold the impairment of the spleen anxiety.
CN201210139937.8 (Publication No. CN102688427A) discloses one kind and treats senile chronic bronchitis
Chinese medicine and the medicine pill preparation method.The Chinese medicine is with cordate houttuynia, Radix Isatidis, rhizome of cyrtomium, careless river car, windproof, loguat leaf, Huang
Stilbene, the bighead atractylodes rhizome, Radix Angelicae Sinensis, the fruit of Chinese magnoliavine, Poria cocos, prepared RHIZOMA PINELLIZE without adju-vant, semen armeniacae amarae, bulbus fritillariae cirrhosae, balloonflower root, coltsfoot, Exocarpium Citri Rubrum, lepidii,semen and radix glycyrrhizae are
Raw material is made.
Existing compound is made up of the herbal medicine of cordate houttuynia, Radix Isatidis etc. 19.Cordate houttuynia, Radix Isatidis, rhizome of cyrtomium, careless river car are equal in side
For the product of bitter-cold herbs expelling heat, the Radix Astragali, the bighead atractylodes rhizome, Poria cocos etc. are the product of temperature compensation, and rhizome of cyrtomium, semen armeniacae amarae are slightly poisonous；This side is for clinical normal
Syndrome of turbid phlegm obstructing lung caused by the diseases caused by external factors perverse trend seen is not particularly suitable.
Accordingly, it is desirable to provide one is first nontoxic, low-cost, syndrome of turbid phlegm obstructing lung really medicable compound is treated.
The content of the invention
Turbid phlegm obstructing lung Chinese medicine composition curative for effect is treated it is an object of the invention to provide a kind of.
It is a further object of the present invention to provide the method for preparing the Chinese medicine composition.
The Chinese medicine composition of the turbid refreshing lung of a kind ofization provided by the invention, is made up of following Chinese medicine：Balloonflower root, licorice, fish raw meat
Grass, Exocarpium Citri Rubrum, Radix Angelicae Sinensis and bulb of thunberg fritillary.
Specifically, the Chinese medicine composition is made up of the Chinese medicine of following parts by weight：Balloonflower root 5-15 parts, licorice 4-8 parts, fish
Raw meat grass 20-40 parts, Exocarpium Citri Rubrum 5-15 parts, Radix Angelicae Sinensis 20-40 parts and bulb of thunberg fritillary 10-20 parts.
Preferably, the Chinese medicine composition is made up of the Chinese medicine of following parts by weight：Balloonflower root 10-15 parts, licorice 6-8 parts,
Cordate houttuynia 30-40 parts, Exocarpium Citri Rubrum 5-15 parts, Radix Angelicae Sinensis 20-40 parts and bulb of thunberg fritillary 10-20 parts.
Further preferably, the Chinese medicine composition is made up of the Chinese medicine of following parts by weight：Balloonflower root 10-15 parts, licorice 6-8
Part, cordate houttuynia 30-40 parts, Exocarpium Citri Rubrum 10-15 parts, Radix Angelicae Sinensis 30-40 parts and bulb of thunberg fritillary 15-20 parts.
Still more preferably, the Chinese medicine composition is made up of the Chinese medicine of following parts by weight：15 parts of balloonflower root, 8 parts of licorice,
20 parts of 40 parts of cordate houttuynia, 15 parts of Exocarpium Citri Rubrum, 40 parts of Radix Angelicae Sinensis and bulb of thunberg fritillary.
In above-mentioned Chinese medicine composition：
The parts by weight can be unit of weight known to the field of medicaments such as μ g, mg, g, kg.
Present invention also offers the preparation method of above-mentioned Chinese medicine composition, this method comprises the following steps：Weighed by proportioning
Each Chinese medicine, add Chinese medicine 6-10 times of decocting measured of gross weight and boil 2-5 times, collect filtrate, be concentrated and dried.
Present invention also offers the preparation containing above-mentioned Chinese medicine composition, by above-mentioned Chinese medicine composition and pharmaceutically acceptable
Carrier or diluent composition.
The preparation is tablet, capsule, pill, granule or oral liquid.
The pharmaceutically acceptable carrier or diluent refer to the conventional pharmaceutical carrier of pharmaceutical field, selected from filler,
One or more in adhesive, disintegrant, lubricant, suspending agent, wetting agent, solvent, surfactant or flavouring.
The filler is selected from starch, sucrose, lactose, mannitol, sorbierite, xylitol, microcrystalline cellulose or glucose
Deng；
Described adhesive is selected from cellulose derivative, alginates, starch, dextrin, gelatin or polyvinylpyrrolidone etc.；
The disintegrant is selected from microcrystalline cellulose, sodium carboxymethyl starch, PVPP, low substituted hydroxy-propyl
Cellulose or Ac-Di-Sol；
The lubricant is selected from stearic acid, polyethylene glycol, calcium carbonate, sodium acid carbonate, superfine silica gel powder, talcum powder or stearic acid
Magnesium；
The suspending agent is selected from superfine silica gel powder, beeswax, cellulose, solid polyethylene glycol；
The wetting agent is selected from glycerine, Tween-80, ethoxy aluminium castor oil or lecithin；
The solvent is selected from ethanol, liquid polyethylene glycol, isopropanol, Tween-80, glycerine, propane diols or vegetable oil, described
Vegetable oil is selected from soybean oil, castor oil, peanut oil, ready-mixed oil etc.；
The surfactant is selected from neopelex, stearic acid, Pluronic F68, fat
Fat acid sorb is smooth or polysorbate (tween) etc.；
The flavouring is selected from Aspartame, Sucralose, essence, citric acid or saccharin sodium.
Present invention also offers the application of above-mentioned Chinese medicine composition and its preparation in the turbid medicine of resolving sputum is prepared, the phlegm
The turbid type for belonging to turbid phlegm obstructing lung for syndrome in asthma, bronchiectasis, cough, pneumonia, bronchitis or chronic pharyngitis.
The turbid refreshing lung drink Chinese medicine composition of provided by the inventionization has advantages below：
1st, Fang Xie：Chinese medicine composition provided by the invention is total to by balloonflower root, licorice, cordate houttuynia, fritillaria thunbergii, Exocarpium Citri Rubrum and Radix Angelicae Sinensis
Six-element Chinese medicine forms.
The pungent scattered hardship of balloonflower root is let out in side, facilitaing lung profit gas, dispelling phlegm and relieving sore-throat apocenosis, and no matter fever and chills can all be applied.
Cordate houttuynia, acrid flavour are slightly cold, return lung warp.Be good at removing summer-heat lung heat, there is tool to disappear the effect of carbuncle apocenosis, for treatment lung carbuncle will
Medicine.
Fritillaria thunbergii, bitter is cold in nature, clearing heat and eliminating phlegm, and dissipating bind disappears carbuncle, for treating cough due to wind-heat evil and Phlegm-heat obstructing lung.Cordate houttuynia
With fritillaria thunbergii mutual reinforcement between to use, there is eliminating heat from the lung, the work(of dissipating bind dissolving phlegm.
Exocarpium Citri Rubrum, acrid flavour are bitter, warm-natured.Return lung the spleen channel.Bright merchant is learned《Medicineization justice》Meaning：" Exocarpium Citri Rubrum, pungent energy row dissipating bind,
The bitter decline that can keep straight on, is sharp gas key medicine.Cover and control phlegm palpus qi-regulating, gas profit phlegm self-healing, therefore with lung spleen is entered, main all phlegm disease, work(occupies all
On phlegm medicine.”
Radix Angelicae Sinensis, sweet, pungent, bitter, warm-natured, main cough with dyspnea is gas medicine in blood, and blood and then gas drop.Exocarpium Citri Rubrum and Radix Angelicae Sinensis phase 5,
Qi-regulating blood-nourishing, eleminating phlegm and freeing channels.
Balloonflower root, radix glycyrrhizae, cordate houttuynia, fritillaria thunbergii, Exocarpium Citri Rubrum, the medicine phases of Radix Angelicae Sinensis six are matched somebody with somebody, and play facilitaing lung profit gas altogether, and turbid, dissipating bind is arranged in resolving sputum
The work(for the carbuncle that disappears.
Chinese medicine composition provided by the invention tremble with fear temperature take into account, the qi and blood people having the same aspiration and interest, mild in medicine property and, eliminating evil without hinder just, have disappear
Phlegm, the work(of expectoration.
2nd, by it is experimentally confirmed that Chinese medicine composition provided by the invention can be used for treat the turbid disease blocked in lung of phlegm,
Effect is better than prior art.
Embodiment
Following examples are used to illustrate the present invention, but are not limited to the scope of the present invention.
Embodiment 1：Chinese medicine composition and its capsule
1st, Chinese medicine material：Balloonflower root 5g, licorice 4g, cordate houttuynia 20g, Exocarpium Citri Rubrum 5g, Radix Angelicae Sinensis 20g and bulb of thunberg fritillary 10g.
2nd, preparation method：
1) balloonflower root, licorice, cordate houttuynia, Exocarpium Citri Rubrum, Radix Angelicae Sinensis and bulb of thunberg fritillary are weighed respectively, add 8 times of amounts of Six-element Chinese medicine weight
Water first soaks 30min, decocts 2 hours, filtering, collects filtrate and the dregs of a decoction respectively, and the dregs of a decoction are boiled with the decocting of 6 times of amounts of medicinal material weight,
Decoct 1.5 hours, merge decoction liquor, filtering, be concentrated into the thick paste that relative density is 1.03 (50 DEG C), dry, pulverize, in obtaining
Medicament extract, it is standby；
2) starch 50g, magnesium stearate 8g are weighed, is then well mixed with Chinese medical extract, is distributed into capsule.
3rd, specification：5g crude drugs/grain.
Embodiment 2：Chinese medicine composition and its capsule
1st, Chinese medicine material：Balloonflower root 10g, licorice 6g, cordate houttuynia 30g, Exocarpium Citri Rubrum 10g, Radix Angelicae Sinensis 30g and bulb of thunberg fritillary 15g.
2nd, preparation method：
1) balloonflower root, licorice, cordate houttuynia, Exocarpium Citri Rubrum, Radix Angelicae Sinensis and bulb of thunberg fritillary are weighed respectively, add 10 times of amounts of Six-element Chinese medicine weight
Water first soaks 30min, decocts 2 hours, filtering, collects filtrate and the dregs of a decoction respectively, and the dregs of a decoction are boiled with the decocting of 8 times of amounts of medicinal material weight,
Decoct 2 hours, filtering, merge decoction liquor, filtering, be concentrated into the thick paste that relative density is 1.06 (50 DEG C), dry, pulverize, obtain
It is standby to Chinese medical extract；
2) starch 35g, microcrystalline cellulose 10g, magnesium stearate 5g are weighed, is then well mixed with Chinese medical extract, is dispensed
Enter capsule.
3rd, specification：5g crude drugs/grain.
Embodiment 3：Chinese medicine composition and its tablet
1st, Chinese medicine material：Balloonflower root 15g, licorice 8g, cordate houttuynia 40g, Exocarpium Citri Rubrum 15g, Radix Angelicae Sinensis 40g and bulb of thunberg fritillary 20g.
2nd, preparation method：
1) balloonflower root, licorice, cordate houttuynia, Exocarpium Citri Rubrum, Radix Angelicae Sinensis and bulb of thunberg fritillary are weighed respectively, add 8 times of amounts of Six-element Chinese medicine weight
Water first soaks 40min, decocts 3 hours, filtering, collects filtrate and the dregs of a decoction respectively, and the dregs of a decoction are boiled with the decocting of 6 times of amounts of medicinal material weight,
Decoct 1 hour, merge decoction liquor, filtering, be concentrated into the thick paste that relative density is 1.03 (50 DEG C), dry, pulverize, obtain Chinese medicine
Extract is standby；
2) microcrystalline cellulose 30g, starch 10g, magnesium stearate 6g are weighed, is then well mixed with Chinese medical extract, directly
Tabletting.
3rd, specification：5g crude drugs/piece.
Embodiment 4：Chinese medicine composition and its granule
1st, Chinese medicine material：Balloonflower root 5g, licorice 4g, cordate houttuynia 30g, Exocarpium Citri Rubrum 15g, Radix Angelicae Sinensis 40g and bulb of thunberg fritillary 20g.
2nd, preparation method：
1) balloonflower root, licorice, cordate houttuynia, Exocarpium Citri Rubrum, Radix Angelicae Sinensis and bulb of thunberg fritillary are weighed respectively, add 8 times of amounts of Six-element Chinese medicine weight
Water first soaks 30min, decocts 3 hours, filtering, collects filtrate and the dregs of a decoction respectively, and the dregs of a decoction are boiled with the decocting of 8 times of amounts of medicinal material weight,
Decoct 1.5 hours, merge decoction liquor, filtering, be concentrated into the thick paste that relative density is 1.03 (50 DEG C), dry, pulverize, in obtaining
Medicament extract is standby；
2) microcrystalline cellulose 30g, starch 20g, magnesium stearate 6g, sucrose 10g, Aspartame 5g are weighed, with traditional Chinese medicine extraction
Thing is pelletized according to established practice method, whole grain, packing, is produced.
3rd, specification：5g crude drugs/bag.
Embodiment 5：Chinese medicine composition and its capsule
1st, Chinese medicine material：Balloonflower root 15g, licorice 8g, cordate houttuynia 30g, Exocarpium Citri Rubrum 5g, Radix Angelicae Sinensis 20g and bulb of thunberg fritillary 10g.
2nd, preparation method：
1) decoctings for weighing balloonflower root, radix glycyrrhizae, cordate houttuynia, Exocarpium Citri Rubrum, Radix Angelicae Sinensis and bulb of thunberg fritillary addition medicinal material 10 times of amounts of weight respectively boil 3
Secondary, decocting time is respectively 2 hours, 1.5 hours, 1.5 hours, merges decoction liquor, filtering, is concentrated into relative density as 1.03
The thick paste of (50 DEG C), dry, pulverize, it is standby to obtain Chinese medical extract；
2) starch 45g, magnesium stearate 5g are weighed, is then well mixed with Chinese medical extract, is distributed into capsule.
3rd, specification：5g crude drugs/grain.
Experimental example 1：Influence to mouse tracheae section phenols contents
1st, experimental animal：Kunming mouse, male and female half and half, 20 ± 2g of weight.
2nd, experiment packet and medication, dosage：64 mouse are randomly divided into 8 groups, i.e. blank control group, implementation
1 group of example, 2 groups of embodiment, 3 groups of embodiment, 4 groups of embodiment, 5 groups of embodiment, 1 group of positive control, 2 groups of positive control.Each Chinese medicine
The daily dosage of formula group mouse, and ginseng document [Xu Shuyun, Bian Rulian, it is old to repair pharmacological experimental methodologies (third edition) [M] north
Capital：People's Health Publisher, 2012：202-203] people's common dose is pressed, enter pedestrian, the conversion of mouse dose,equivalent, daily morning and evening
Gastric infusion at twice.Blank control group is with warm water gavage, and (Beijing is same with Exocarpium Citri Rubrum cough stopping oral liquor gavage for 1 group of positive control
The production of Ren Tang limited companies Tongrentang Pharmaceutical Factories, dosage 3.03ml/kg body weight), 2 groups of positive control, 5% ammonium chloride filling
Stomach (brand：Amresco, article No. 0621-500G, the place of production：The U.S..Dosage：1g/kg body weight).
3rd, experimental method：The equal continuous gavage of each group mouse 5 days, 30min after last dose, intraperitoneal injection 0.5% are phenol red molten
Liquid 0.5ml/ only, after 30min, takes off cervical vertebra and put to death.Tracheae is separated, with surgical thread respectively in thyroid gland cartilage lower edge and tracheorrhaphy
Cha Chu is ligatured, clip tracheae at self-ligating, and 5%NAHCO is drawn with 1mL syringes3Solution 0.5mL injects tracheal strips, connects repeatedly
Continuous push away is taken out 3 times, is merged flushing liquor about 1.2-1.5mL, 3000r/min centrifugation 10min, is taken supernatant to be determined at 546nm wavelength
Absorbance (OD values), OD values are substituted into phenol red standard curve, draw phenol red concentration.
4th, statistical method：Measurement data with mean add and subtract standard deviation () represent, using SPSS17.0 statistical softwares, group
Between compare using one-way analysis of variance.
5th, experimental result：It is shown in Table 1
Table 1 to mouse tracheae section phenols contents influence ()
Note：Compared with blank control group,ΔP ＜ 0.05,ΔΔP ＜ 0.01
The result of table 1 is shown：Compared with blank control group, embodiment 1-5 each group mouse tracheae section phenols contents differences are equal
There is significant difference (P ＜ 0.05 or P ＜ 0.01), mouse tracheae section phenols contents substantially increase, with the curative effect of embodiment 2 most
It is good.
Test result indicates that Chinese medicine composition provided by the invention, has expectoration effect, and effect is better than prior art.
Inventor is had found when Apophlegmatisant ratio in the Chinese medicine composition of the present invention where appropriate, its effect is than containing Apophlegmatisant simultaneously
The higher composition effect of content is more preferably.
Experimental example 2：Rat expectoration is tested
1st, experimental animal：SD rats, 200 ± 20g of weight, male and female half and half.
2nd, experiment packet and medication, dosage：48 mouse are randomly divided into 8 groups, i.e. blank control group, formula
1 group of embodiment, 2 groups of embodiment, 3 groups of embodiment, 4 groups of embodiment, 5 groups of embodiment, 1 group of positive control, 2 groups of positive control, often
Group 6.The daily dosage ginseng document of each Chinese medicine preparation group rat [Xu Shuyun, Bian Rulian, it is old to repair pharmacological experimental methodologies the (the 3rd
Version) [M] Beijing：People's Health Publisher, 2012：202-203] people's common dose is pressed, enter pedestrian, the conversion of rat dose,equivalent,
Daily gastric infusion at twice sooner or later.Blank control group is with warm water gavage, and 1 group of positive control is with Exocarpium Citri Rubrum cough stopping oral liquor gavage
5% chlorine of 2 groups of (Beijing TongrenTang Co., Ltd Tongrentang Pharmaceutical Factory produce, dosage 2.1ml/kg body weight), positive control
Change ammonium gavage (brand：Amresco, article No. 0621-500G, the place of production：The U.S..Dosage：1g/kg body weight).
3rd, experimental method：After water 12h is can't help in fasting before experiment, after 25% urethane 1.0g/kg intraperitoneal injection of anesthesia, position is carried on the back
Fixed, exposure tracheae, (or tracheae thyroid cartilage lower edge or is under thyroid gland cartilage for the 3rd cartilage ring position under thyroid cartilage ring
Edge is hit exactly between two cartilaginous rings) aperture is pricked with sharp injection needle, insert long 120mm internal diameters 0.5mm capillary glass-tube one
Root, capillary just contact tracheae lower surface, so as to drawing organ rear portion sputum.Sputum length is drawn using capillary and is used as phlegm
Secretory volume, before record administration after 2h normal secretions amount, continue to observe 2h sputum secretory volumes after gastric infusion, before and after comparing administration
Average sputum secretory volume per hour, and the credit analysis that takes statistics.
Gavage gives the corresponding test liquids of 1.0mL/100g to urethane respectively.Water 8-12h, last dose are can't help in fasting before experiment
After 1h, the interior amounts of expectoration suctioned out of 2h after record administration, with capillary, administration forward backward averaging phlegm secretory volume hourly and administration are calculated
Gain percentage afterwards.
4th, statistical method：Measurement data with mean add and subtract standard deviation () represent, using SPSS17.0 statistical softwares, group
Between compare using one-way analysis of variance.
5th, experimental result：It is shown in Table 2
Table 2 to rat expectoration amount influence ()
Note：Compared with blank control group,ΔP ＜ 0.05,ΔΔP ＜ 0.01.
The result of table 2 is shown：Compared with blank control group, embodiment 1-5 each group rat expectoration amounts have significant difference (P
＜ 0.05), rat expectoration amount substantially increases, optimal with the curative effect of embodiment 2.Test result indicates that Chinese medicine provided by the invention
Composition has expectoration effect, and effect is better than prior art.Inventor has found to arrange when in the Chinese medicine composition of the present invention simultaneously
Phlegm drug ratios where appropriate, its effect than containing the higher composition effect of expectoration medicament contg more preferably.
Although above the present invention is made to retouch in detail with general explanation, embodiment and experiment
State, but on the basis of the present invention, it can be made some modifications or improvements, this is apparent to those skilled in the art
's.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, are belonged to claimed
Scope.
Claims (8)
1. the Chinese medicine composition of the turbid refreshing lung of a kind ofization, it is characterised in that the Chinese medicine composition is made up of the Chinese medicine of following parts by weight：
Balloonflower root 10-15 parts, licorice 6-8 parts, cordate houttuynia 30-40 parts, Exocarpium Citri Rubrum 5-15 parts, Radix Angelicae Sinensis 20-40 parts and bulb of thunberg fritillary 10-20 parts.
2. Chinese medicine composition according to claim 1, it is characterised in that the Chinese medicine composition by following parts by weight Chinese medicine
It is made：Balloonflower root 10-15 parts, licorice 6-8 parts, cordate houttuynia 30-40 parts, Exocarpium Citri Rubrum 10-15 parts, Radix Angelicae Sinensis 30-40 parts and bulb of thunberg fritillary 15-20
Part.
3. Chinese medicine composition according to claim 2, it is characterised in that the Chinese medicine composition by following parts by weight Chinese medicine
It is made：20 parts of 15 parts of balloonflower root, 8 parts of licorice, 40 parts of cordate houttuynia, 15 parts of Exocarpium Citri Rubrum, 40 parts of Radix Angelicae Sinensis and bulb of thunberg fritillary.
A kind of 4. method for preparing the Chinese medicine composition described in claim any one of 1-3, it is characterised in that this method include with
Lower step：Each Chinese medicine is weighed by proportioning, Chinese medicine 6-10 times of decocting measured of gross weight is added and boils 2-5 times, collects filtrate, concentration is dry
It is dry.
5. the preparation made of the Chinese medicine composition described in claim any one of 1-3, it is characterised in that said preparation is by Chinese medicine group
Compound and pharmaceutically acceptable carrier are made.
6. preparation according to claim 5, it is characterised in that the preparation is tablet, capsule, pill, granule or mouth
Take liquid.
7. the Chinese medicine composition described in claim any one of 1-3 or the preparation described in claim 5 or 6 are in the turbid refreshing lung of preparationization
Medicine in application.
8. application according to claim 7, it is characterised in that the turbid refreshing lung of describedization is applied to asthma, bronchiectasis, cough
Cough, pneumonia, bronchitis or chronic pharyngitis syndrome belong to the type of turbid phlegm obstructing lung.
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| CN104510938A (en) * | 2014-12-23 | 2015-04-15 | 蓝蓉蓉 | Traditional Chinese medicinal formula for treating infantile pneumonia and preparation method for syrup of traditional Chinese medicinal formula |
| CN109223956B (en) * | 2018-10-17 | 2021-06-18 | 中国人民解放军第二军医大学 | Traditional Chinese medicine composition for treating cough and extraction method and application thereof |
| CN109200125A (en) * | 2018-11-30 | 2019-01-15 | 哈工大机器人（山东）智能装备研究院 | A kind of campanulaceae compound buccal lozenge and preparation method thereof causing respiratory disease for treating haze weather |
| CN113116986B (en) * | 2021-05-31 | 2022-09-02 | 广东金和健康科技有限公司 | Traditional Chinese medicine composition for chronic obstructive pulmonary disease rehabilitation period and application thereof |
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