CN113116986B - Traditional Chinese medicine composition for chronic obstructive pulmonary disease rehabilitation period and application thereof - Google Patents
Traditional Chinese medicine composition for chronic obstructive pulmonary disease rehabilitation period and application thereof Download PDFInfo
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Abstract
The invention belongs to the technical field of traditional Chinese medicine compositions, and particularly relates to a traditional Chinese medicine composition for a chronic obstructive pulmonary disease rehabilitation period and application thereof. The invention provides a traditional Chinese medicine composition for a rehabilitation period of chronic obstructive pulmonary disease, which comprises the following raw materials: almond, momordica grosvenori, red tangerine peel, medlar, mint and dark tea. The traditional Chinese medicine composition can effectively treat the complications of the COPD patients in the convalescence period by combining the medicines, and clinical tests show that the traditional Chinese medicine composition can effectively treat the symptoms of chronic cough, constipation and the like of the COPD patients in the convalescence period.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicine compositions, and particularly relates to a traditional Chinese medicine composition for a chronic obstructive pulmonary disease rehabilitation period and application thereof.
Background
Chronic Obstructive Pulmonary Disease (COPD) is a serious chronic respiratory disease with a high number of patients and a high mortality rate. The disease course is slowly progressive, which can seriously affect the labor capacity and the life quality of patients.
Although various clinical symptoms of COPD patients are relieved after the acute attack period, the lung function of the COPD patients is still deteriorated, and the COPD patients frequently have repeated attacks of diseases and gradually generate complications due to the influence of self-deficiency and various external harmful factors.
Disclosure of Invention
In order to solve the problems, the invention provides a traditional Chinese medicine composition for the rehabilitation period of chronic obstructive pulmonary disease and application thereof. The traditional Chinese medicine composition provided by the invention has the effects of eliminating phlegm and relieving cough, relaxing bowel and nourishing liver and kidney, and can effectively treat various complications of COPD patients in rehabilitation, such as chronic cough, constipation and the like.
In order to achieve the purpose, the invention provides the following technical scheme:
the invention provides a traditional Chinese medicine composition for a rehabilitation period of chronic obstructive pulmonary disease, which comprises the following raw materials in parts by mass: 5-10 parts of almond, 5-10 parts of momordica grosvenori, 5-10 parts of exocarpium citri rubrum, 5-10 parts of medlar, 5-10 parts of mint and 5-10 parts of dark green tea.
Preferably, the traditional Chinese medicine composition comprises the following raw materials in parts by mass: 6 parts of almond, 8 parts of momordica grosvenori, 7 parts of exocarpium citri rubrum, 9 parts of medlar, 10 parts of mint and 5 parts of dark tea.
Preferably, the dosage form of the traditional Chinese medicine composition comprises powder.
The invention also provides application of the traditional Chinese medicine composition in preparing a medicine for improving the immune function of the chronic obstructive pulmonary disease in the convalescence stage.
The invention also provides application of the traditional Chinese medicine composition in preparing a medicine for treating complications of chronic obstructive pulmonary disease in the convalescent period.
The invention also provides application of the traditional Chinese medicine composition in preparing a treble medicine for treating chronic obstructive pulmonary disease in a convalescent period.
The invention also provides application of the traditional Chinese medicine composition in preparing a medicine for treating constipation in the rehabilitation stage of chronic obstructive pulmonary disease.
The invention provides a traditional Chinese medicine composition for a rehabilitation period of chronic obstructive pulmonary disease, which comprises the following raw materials: almond, momordica grosvenori, red tangerine peel, medlar, mint and dark tea. The traditional Chinese medicine composition provided by the invention takes the almond as a monarch drug, and has the effects of eliminating phlegm, relieving cough, moistening the intestines and relaxing the bowels; fructus momordicae and red tangerine peel are used as ministerial drugs to strengthen the efficacy of reducing phlegm and relieving cough; fructus Lycii has effects of nourishing liver and kidney, and herba Menthae has effects of dispelling pathogenic wind and relieving cough, and both of them are adjuvant drugs; the black tea has elegant and mellow fragrance and sweet and mellow taste, and is used as a messenger medicine after being blended with the above medicines. The combination of the medicines can effectively treat the complications of COPD patients in the convalescent period. Clinical tests show that the traditional Chinese medicine composition can effectively treat symptoms such as drowsiness, fatigue, chronic cough, constipation and the like of COPD patients in the rehabilitation period.
Detailed Description
The invention provides a traditional Chinese medicine composition for a rehabilitation period of chronic obstructive pulmonary disease, which comprises the following raw materials in parts by mass: 5-10 parts of almond, 5-10 parts of momordica grosvenori, 5-10 parts of exocarpium citri rubrum, 5-10 parts of medlar, 5-10 parts of mint and 5-10 parts of dark green tea. The traditional Chinese medicine composition provided by the invention is prepared according to the theoretical principles of 'phlegm reducing and cough relieving' and 'lung and large intestine exterior and interior' in traditional Chinese medicine, has the effects of reducing phlegm and cough relieving, relaxing bowel and nourishing liver and kidney, and can effectively treat symptoms such as chronic cough, constipation and the like generated by COPD patients in the rehabilitation period. Meanwhile, the traditional Chinese medicine composition provided by the invention does not need to adjust the dosage according to the condition of a patient in practical application, and is convenient for market popularization and application. In addition, the traditional Chinese medicine composition provided by the invention is high in safety, good in taste and easy to accept by patients, improves the acceptability of the patients, and is suitable for long-term administration by patients with chronic obstructive pulmonary disease.
The traditional Chinese medicine composition comprises, by mass, 5-10 parts of almonds, preferably 5-7 parts of almonds, and most preferably 6 parts of almonds. The almond is preferably bitter almond, can lower lung qi to relieve cough and asthma, can moisten intestines to relieve constipation, and can play a role in relieving cough and asthma and relaxing bowel.
The traditional Chinese medicine composition comprises, by mass, 5-10 parts of momordica grosvenori, more preferably 7-9 parts of momordica grosvenori and most preferably 8 parts of apricot kernel. In the invention, the momordica grosvenori has the effects of clearing heat, moistening lung, relieving sore throat, easing up voice, relaxing bowel, resisting oxidation, removing free radicals and enhancing immunity.
The traditional Chinese medicine composition comprises, by mass, 5-10 parts of tangerine peel, more preferably 6-8 parts of tangerine peel, and most preferably 7 parts of apricot kernel. In the invention, the exocarpium citri rubrum plays roles of eliminating dampness and phlegm, regulating qi and relieving epigastric distention, and also can treat food stagnation, vomiting and hiccup and other symptoms, and the momordica grosvenori and the exocarpium citri rubrum are ministerial drugs and enhance the efficacies of eliminating phlegm and relieving cough.
Based on the mass parts of the almonds, the raw materials of the traditional Chinese medicine composition comprise 5-10 parts of the Chinese wolfberry, more preferably 8-10 parts, and most preferably 9 parts. In the invention, the medlar has the function of improving the body immunity.
The raw materials of the traditional Chinese medicine composition comprise 5-10 parts of mint, more preferably 9-10 parts of mint, and most preferably 10 parts of almond based on the mass parts of almond. In the invention, the mint has the effects of dispelling wind and heat, clearing head and eyes, relieving sore throat, promoting eruption, soothing liver and relieving depression, and has a remarkable effect on the digestive system and the respiratory system, and the medlar and the mint are adjuvant drugs and have the effects of nourishing liver and kidney, dispelling wind and relieving cough.
Based on the mass parts of the almonds, the raw materials of the traditional Chinese medicine composition comprise 5-10 parts of dark green tea, more preferably 5-7 parts of dark green tea, and most preferably 5 parts of dark green tea. In the invention, the black tea has the functions of preventing and treating various diseases such as hyperglycemia, hypertension, hyperlipidemia and the like, and the black tea is used as a messenger drug for blending the above medicines.
In the present invention, the dosage form of the Chinese medicinal composition preferably includes powder. The traditional Chinese medicine composition provided by the invention is preferably prepared into powder, and is taken after being infused with boiling water, wherein the taking frequency of the medicine is three times a day, and each time is 5 g. The traditional Chinese medicine composition provided by the invention is simple in dosage form and can be used simply.
The invention also provides application of the traditional Chinese medicine composition in preparing a medicine for improving the immune function of the chronic obstructive pulmonary disease in the convalescence stage. The application provided by the invention can effectively improve the resistance of patients through the combination of various medicines.
The invention also provides application of the traditional Chinese medicine composition in preparing a medicine for treating complications of chronic obstructive pulmonary disease in the convalescent period. In the present invention, the complications include drowsiness, lassitude, trembling and constipation. Clinical tests show that the traditional Chinese medicine composition can effectively treat complications of patients with chronic obstructive pulmonary diseases in a convalescent period.
The invention also provides application of the traditional Chinese medicine composition in preparing a treble medicine for treating chronic obstructive pulmonary disease in a convalescent period. Through three-month treatment and observation and by comparing tremble symptom scores, the application of the medicine provided by the invention can effectively treat tremble symptoms of patients in the convalescent period of chronic obstructive pulmonary disease.
The invention also provides application of the traditional Chinese medicine composition in preparing a medicine for treating constipation in the rehabilitation stage of chronic obstructive pulmonary disease. Through three-month treatment and observation, the constipation symptom of patients with chronic obstructive pulmonary disease in the convalescent period can be effectively treated by comparing the integral of the constipation symptom.
For further illustration of the present invention, the following examples are provided to describe the Chinese medicinal composition for the convalescent period of chronic obstructive pulmonary disease and its application in detail, but they should not be construed as limiting the scope of the present invention.
Examples
1. Pharmaceutical preparation
Taking the following components in parts by mass: 6 parts of almond, 8 parts of momordica grosvenori, 7 parts of exocarpium citri rubrum, 9 parts of medlar, 10 parts of mint and 5 parts of dark green tea.
The raw materials are prepared according to the following method: the coarse powder is mixed evenly and packed into tea bags for sealing, and each bag is 5 g. The patient takes the medicine 1 bag 3 times a day.
2. Pharmaceutical use
(1) Case selection
The total 100 patients suffering from chronic obstructive pulmonary disease in Guangzhou area from 2 months to 2019 months in 2018 (all in the chronic obstructive pulmonary disease rehabilitation period) are counted. 66 men and 34 women among the patients; the patients are randomly divided into a control group and a treatment group, wherein 50 patients in the treatment group and 50 patients in the control group are treated. The average age of the patients is 55 years, and the differences of the two groups of sex, age distribution, main symptom score and the like have no statistical significance.
(2) Group administration
Control group: oxygen therapy is added in conventional respiratory rehabilitation training.
Treatment groups: the traditional Chinese medicine formula is taken in addition to oxygen therapy for conventional respiratory rehabilitation training, 3 times a day, and 1 bag each time. It can be administered after infusing with boiling water.
(3) Main observation index
The treatment time is 3 months. The main observation index is the change in symptoms before and after treatment of cough and constipation.
(4) Criteria for efficacy assessment
Refer to the standard of curative effect of diagnosis of traditional Chinese medicine diseases issued by the State administration of traditional Chinese medicine. The clinical cure is as follows: symptoms basically disappear after treatment, and the integral of the symptoms is 0-1 point;
the effect is shown: the symptoms are obviously improved after treatment, and the integral of the symptoms is reduced by more than or equal to 2/3;
the method has the following advantages: the symptoms are improved after treatment, and the symptom score is reduced by more than or equal to 1/3;
and (4) invalidation: failure to reach effective standard or aggravation.
(5) Therapeutic effects
After each patient had undergone 3 months of treatment, the symptom score comparison data before and after treatment is shown in table 1.
TABLE 1 comparison of the score of each symptom in the two groups after treatment
As can be seen from table 1, after the treatment with the traditional Chinese medicine composition provided by the present invention, the symptom score of the patients in the treatment group is significantly decreased, and the decrease degree is much higher than that of the control group, which indicates that the traditional Chinese medicine composition provided by the present invention can effectively treat the constipation and tremble symptoms of the convalescent patients. Furthermore, it was observed that the treatment group of patients generally improved the treatment compliance after treatment.
Although the present invention has been described with reference to the preferred embodiments, it should be understood that various changes and modifications can be made therein by those skilled in the art without departing from the spirit and scope of the invention as defined in the appended claims.
Claims (5)
1. A traditional Chinese medicine composition for a rehabilitation period of chronic obstructive pulmonary disease comprises the following raw materials in parts by mass: 5-10 parts of almond, 5-10 parts of momordica grosvenori, 5-10 parts of exocarpium citri rubrum, 5-10 parts of medlar, 5-10 parts of mint and 5-10 parts of dark green tea;
the preparation method of the traditional Chinese medicine composition comprises the steps of coarse powder and even mixing.
2. The traditional Chinese medicine composition according to claim 1, which is prepared from the following raw materials in parts by mass: 6 parts of almond, 8 parts of momordica grosvenori, 7 parts of exocarpium citri rubrum, 9 parts of medlar, 10 parts of mint and 5 parts of dark green tea.
3. The composition of claim 1 or 2, wherein the composition is in the form of a powder.
4. Use of a Chinese medicinal composition according to any one of claims 1-3 in the preparation of a treble medicament for treating chronic obstructive pulmonary disease in convalescent stages.
5. Use of the Chinese medicinal composition of any one of claims 1 to 3 in the preparation of a medicament for treating constipation during the convalescent period of chronic obstructive pulmonary disease.
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| CN104117043A (en) * | 2014-07-25 | 2014-10-29 | 河南科技大学第一附属医院 | Preparation method of traditional Chinese medicine granules for treating chronic bronchitis |
| CN104173705B (en) * | 2014-09-04 | 2018-04-03 | 北京中医药大学 | Chinese medicine composition of the turbid refreshing lung of a kind ofization and preparation method thereof |
| CN111743942A (en) * | 2019-06-21 | 2020-10-09 | 中日友好医院 | Traditional Chinese medicine composition for treating acute exacerbation of chronic obstructive pulmonary disease and preparation method thereof |
| CN111588757A (en) * | 2019-06-21 | 2020-08-28 | 中日友好医院 | Traditional Chinese medicine composition for treating chronic obstructive pulmonary disease in stable phase and preparation method thereof |
| CN112675278A (en) * | 2021-01-12 | 2021-04-20 | 广州泽力医药科技有限公司 | Composition for moistening lung to arrest cough and inhibiting lung inflammatory reaction and preparation method and application thereof |
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