CN105943856B - A kind of Chinese medicine composition and its preparation with cough-relieving function containing Portugal - Google Patents
A kind of Chinese medicine composition and its preparation with cough-relieving function containing Portugal Download PDFInfo
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- CN105943856B CN105943856B CN201610380808.6A CN201610380808A CN105943856B CN 105943856 B CN105943856 B CN 105943856B CN 201610380808 A CN201610380808 A CN 201610380808A CN 105943856 B CN105943856 B CN 105943856B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/486—Millettia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
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Abstract
The invention discloses a kind of Lingnan features Chinese medicine composition and its preparation with cough-relieving function containing Portugal, is formed: Portugal: beautiful millettia root: Chinese pholidota pseudobulb or herb: berchemia lineata=(2-4): (1.5-3): (1.5-3): (1.5-3) by the Lingnan features traditional Chinese medicine of following weight ratio.The present invention has the effect of Yin nourishing and lung moistening, cough-relieving apophlegmatic, reinforcing spleen and kidney, and therapeutic effect is good, and securely and reliably, using Lingnan features Chinese medicine, raw material is easy to get.
Description
Technical field
The present invention relates to field of medicaments, specially a kind of Lingnan features Chinese traditional medicine composition with cough-relieving function containing Portugal
Object and its preparation.
Technical background
Cough is a kind of protectiveness respiration reflex movement of human body, can effectively be removed in respiratory tract by cough reflex
Secretion or the foreign matter for entering air flue.But cough also has a negative side, and acutely cough can lead to hemorrhage in respiratory tract, such as long-term,
Frequently, acutely cough influences work, rest, or even causes to have sore throat, hoarse voice and respiratory muscle pain.
At present to there are the mistaken ideas in many treatments in the diagnosis and treatment of cough, in terms of clinical application, there is abuse antibiosis
Element, a medicine hundred control, medication not in time, ignore it is additive, ignore dietary adjustments, there is no the problems such as diagnosis and prescription.
Cough is often divided into exogenous cough's (cough due to wind-cold evil, cough due to wind-heat evil, wind-dryness cough etc.) and internal injury by traditional Chinese medicine
Cough (phlegm dampness in lungs, the strongly fragrant lung of phlegm heat, liver-fire attacking lung, syndrome of deficiency of lung yin etc.)；.The cold of insufficiency type, which is coughed, belongs to the scope of endogenous cough.Mainly
Due to ferritic weakness, exogenous disease cold-evil, perverse trend visitor's lung, Lung Qi obstraction or real example have coughed for a long time, and lung spleen kidney is injured, so that real example
Turn void, heat syndrome transforming into cold syndrome.It is mainly shown as that the thin color of cough, expectoration is white, cough sound is low very brief, and asthma, shape is trembled with fear limb cold, not thirsty, tongue
Light whitish tongue, deep thready pulse.Chinese medicine is mainly with expelling wind and cold pathogens, ventilating the lung and relieving cough to the treatment that the cold of insufficiency type is coughed, and assistant is with qi-restoratives medicine, enriching yin profit
Lung, strengthening spleen, tonifying kidney.If there is phlegm, person is helped with eliminating the phlegm medicament, is particular about diagnosis and prescription, curative for effect, treating both manifestation and root cause of disease, without resistance in the treatment
Pharmacological property, Small side effects can be used for a long time.
Summary of the invention
The purpose of the present invention is to provide a kind of Lingnan features Chinese medicine composition with cough-relieving function containing Portugal,
It can cough-relieving apophlegmatic.
To achieve the above object, the present invention adopts the following technical scheme: a kind of ridge with cough-relieving function containing Portugal
Southern Special Traditional Chinese Medicine composition, it is characterised in that formed by the Lingnan features traditional Chinese medicine of following weight ratio: Portugal: beautiful millettia root: stone
Flat peach: berchemia lineata=(2-4): (1.5-3): (1.5-3): (1.5-3).
Preferably, it is formed by the Lingnan features traditional Chinese medicine of following weight ratio: Portugal: beautiful millettia root: Chinese pholidota pseudobulb or herb: berchemia lineata=
(3-4)∶(2-3)∶(1.5-2.5)∶(1.5-2.5)。
Most preferably, it is formed by the Lingnan features traditional Chinese medicine of following weight ratio: Portugal: beautiful millettia root: Chinese pholidota pseudobulb or herb: berchemia lineata
=4: 3: 1.8: 2.
The Chinese medicine composition is decoction.
A kind of Lingnan features Chinese medicine composition with cough-relieving function containing Portugal, is with the Traditional Chinese medicine composition formula
The extract of middle component is effective component, adds preparation made from pharmaceutic adjuvant.
The dosage form of the preparation is oral solution, syrup, capsule, tablet, particle electuary, pill or aerosol.
The extract is water extract.
The present invention has the effect of Yin nourishing and lung moistening, cough-relieving apophlegmatic, reinforcing spleen and kidney, and therapeutic effect is good, securely and reliably, uses
Lingnan features Chinese medicine, raw material are easy to get.
Specific embodiment
The present invention is a kind of Lingnan features Chinese medicine composition with cough-relieving function containing Portugal, by following weight ratio
Lingnan features traditional Chinese medicine forms: Portugal: beautiful millettia root: Chinese pholidota pseudobulb or herb: berchemia lineata=(2-4): (1.5-3): (1.5-3): (1.5-
3).Preferably, it is formed by the Lingnan features traditional Chinese medicine of following weight ratio: Portugal: beautiful millettia root: Chinese pholidota pseudobulb or herb: berchemia lineata=(3-4)
:(2-3):(1.5-2.5):(1.5-2.5).Most preferably, it is formed by the Lingnan features traditional Chinese medicine of following weight ratio: Portugal:
Beautiful millettia root: Chinese pholidota pseudobulb or herb: berchemia lineata=4: 3: 1.8: 2.
The Chinese medicine composition can be decoction.Alternatively, the convenience taken for patient and according to the characteristic of extract,
Preparation can be made, using the extract of component in the Traditional Chinese medicine composition formula as effective component, add corresponding pharmaceutic adjuvant, press
Any oral preparation is prepared into according to Chinese medicine conventional formulation technique.The dosage form of preparation can be oral solution, syrup, capsule
Agent, tablet, particle electuary, pill or aerosol etc..Wherein extract is preferably water extract, can extraction process by water system routinely
It is standby, such as: take the medicinal material of formula to mix according to monarch prescription ratio, every time with the water of 8~12 times of medicinal material deals, after immersion
It heating and refluxing extraction 1~3 hour, extracts 1~3 time, filtering, merging filtrate is concentrated to every 0.5~5.0g of milliliter contained, i.e.,
?.Adding corresponding pharmaceutic adjuvant to extract again can be prepared into any oral preparation.
Lingnan features Chinese medicine used in the present invention has the feature that
Portugal: for the fruit of myrtle Portugal Syzygium jambos (L.) Alston., property is hot, acid sweet in flavor,
Return lung, the spleen channel have the effect of moistening lung to arrest cough, warm stomach invigorating the spleen.Portugal is recorded in " book on Chinese herbal medicine new again " have control that the deficiency syndrome of the lung is cold to cough, blood-breaking
Product subcutaneous ulcer tumor, the effect of good efficacy to suffering from a deficiency of the kidney.
Beautiful millettia root: it is sweet natured for the root of leguminous plant beautiful millettia Millettia specisoa Champ, return
Lung, kidney channel, have qi-restoratives moistening lung, the active effect of strengthening tendons, and modern pharmacological research discovery beautiful millettia root can dramatically increase mouse tracheae
Phenols contents promote the intratracheal prepared Chinese ink movement of pigeon, reduce ammonium hydroxide initiation mouse and citric acid causes guinea pig cough's reaction
Number extends cough latent period, and to guinea pig bronchial asthma caused by antihistamine-acetylcholine, it is certain to show that beautiful millettia root has
Antibechic, eliminating the phlegm and the effect relievingd asthma, while also have the function of adjust immune function of mice.
Chinese pholidota pseudobulb or herb: it is cool in nature for the pseudobulb or herb of orchid Chinese pholidota pseudobulb or herb Pholidota chinensis Lindl.,
The effect of sweet in flavor, light, return lung, kidney channel have Yin nourishing and lung moistening, relieving cough and reducing sputum, can control endogenous cough.
Berchemia lineata: medicinal material berchemia lineata is Rhamnaceae plant berchemia lineata and congener littleleaf supplejackherba Berchemia
The stem rattan of lineata (L.) DC. or root, mild-natured, bitter, micro-puckery is distributed in lung channel, has kobadrin, QI invigorating of reinforcing the kidney, removing blood stasis and hemostasis
The effect of.
The hot taste thuja acid of Portugal property in we, enters the warp of lung spleen two, qi-restoratives moistening lung, the cold cough-relieving of temperature, is monarch drug in a prescription, compatibility beautiful millettia root,
Berchemia lineata is ministerial drug, and beautiful millettia root has good nourishing lung yin effect, can assist monarch drug in a prescription enhancing qi-restoratives effect, and berchemia lineata antibechic is dispelled
Phlegm enhances monarch drug in a prescription antitussive action, and compatibility Chinese pholidota pseudobulb or herb is adjuvant, enhances relieving cough and reducing sputum function, while Chinese pholidota pseudobulb or herb is made with yin-nourishing
With making Portugal heat not impairment of yin, complete each medicine cough-relieving effect in side complements each other, and can effectively realize moistening lung to arrest cough, the cold resolving sputum effect of temperature.
Below with reference to embodiment, the present invention is further illustrated, but the present invention is not limited thereto specific examples:
Embodiment 1
Portugal 130, beautiful millettia root 97.5g, Chinese pholidota pseudobulb or herb 58.5g are taken, berchemia lineata 65g adds 10 times of amount water, impregnates 30 minutes, returns
Stream extracts 1.5 hours, extracts 2 times, and filtering, merging filtrate is concentrated into 250ml, obtains decoction.
Embodiment 2
Portugal 260g, beautiful millettia root 195g, Chinese pholidota pseudobulb or herb 117g, berchemia lineata 130g are taken, 10 times of amount water are added, is impregnated 30 minutes, is returned
Stream extracts 1.5 hours, extracts 2 times, and filtering, merging filtrate is concentrated into 250ml, obtains decoction.
Embodiment 3
Portugal 260g, beautiful millettia root 195g, Chinese pholidota pseudobulb or herb 117g, berchemia lineata 130g are taken, 10 times of amount water are added, is impregnated 45 minutes, is returned
Stream extracts 2 hours, extracts 3 times, and filtering, merging filtrate is concentrated into 250ml, obtains decoction.
Embodiment 4
1 gained decoction of above-described embodiment is taken, 10 times of amount water are added, agitating and heating is boiled, boiled 20 minutes, to be cooled to 30
At~40 DEG C, appropriate chitosan and potassium sorbate is added, be stirred to dissolve uniformly, filtering, finally plus pure water adjust to
1000ml is filtered, and packing sterilizes to get oral solution.Every oral solution 10ml.
Embodiment 5
Take 1 gained decoction of above-described embodiment, separately take sucrose 600g that simple syrup is made, to syrup temp be down to 60 DEG C hereinafter,
Be added 1 decoction of embodiment stirred evenly with ethyl hydroxy benzoate 0.lg, vanilla 2ml, filter, from filter add pure water adjust to
1000ml is mixed, and packing sterilizes to get syrup.Every 100ml.
Embodiment 6
1 gained decoction of above-described embodiment is taken, is concentrated, it is dry, obtain dry extract；Dry extract 16.7g is taken, fine powder is ground into, is added
Entering suitable medical starch and superfine silica gel powder, mix, crosses 14 meshes and pelletize, 65 DEG C of dryings carry out whole grain after 14 meshes,
Then suitable magnesium stearate is added, mixes, is pressed into 100 to get tablet.Every slice weight 0.5g.
Embodiment 7
1 gained decoction of above-described embodiment is taken, is concentrated, it is dry, obtain dry extract；Dry extract 14.6g is taken, fine powder is ground into, is added
Enter suitable medical starch and magnesium stearate, be uniformly mixed, sieving is packed into capsule, is made 100 to get hard capsule.Every intragranular
Tolerant heavy 0.2g.
Embodiment 8
1 gained decoction of above-described embodiment is taken, is concentrated, it is dry, obtain dry extract；Dry extract 18.2g is taken, fine powder is ground into, is added
Enter suitable dextrin and lactose, mix, granulation, 65 DEG C of dryings, cross 14 meshes carry out whole grain, packing, be made 100 packet to get
Granula.Every packet weight 5g.
Embodiment 9
1 gained decoction of above-described embodiment is taken, is concentrated, it is dry, obtain dry extract；Dry extract 20.2g is taken, fine powder is ground into,
Sieving mixes, and with water pill, is made 100 to get pill, every weight 1.5g.
Embodiment 10
1 gained decoction of above-described embodiment is taken, is concentrated, it is dry, dry extract is obtained, dry extract 15.7g is taken, is ground into fine powder,
It is extracted 3 times with alcohol reflux, 1.5 hours every time, extracting solution filtered after letting cool, and propylene glycol 32.5ml, flavoring banana essence is added
0.62ml adds ethyl alcohol to adjust total amount to 100ml, mixes, place, filtration dispenses up to aerosol, every bottle of 10ml.
Experimental example: the cough-relieving experiment of cough model mouse
1 material
1.1 animals: SPF grades of KM mouse, male, 20-40g, 32 [it is provided by Nanfang Medical Univ's Experimental Animal Center,
Animal certificate number: SCXK (Guangdong) 2011-2015].
1.2 reagents: (present invention is prepared tested material by embodiment 1 and embodiment 2: being added 10 times of amount water, is impregnated 30 minutes, returns
Stream extracts 1.5 hours, extracts 2 times, and filtering, it is respectively 1.404g/ml, 2.808g/ containing crude drug that merging filtrate, which is concentrated into 250ml,
Ml), codeine phosphate (being provided by the attached hospitals of traditional Chinese and western medicine, Nanfang Medical Univ, 15mg/ piece), concentrated ammonia liquor (25%-
28%).
2 methods
Mouse 32 are taken, physiological saline blank group, codeine phosphate group, the present invention is randomly divided into and high dose and low dose is administered
Amount group, blank group stomach-filling physiological saline, positive group stomach-filling codeine phosphate, remaining corresponding medical fluid of each group stomach-filling, stomach-filling volume are
10mL/kg, once a day, continuous 3d, ad lib during experiment.
After the last administration, each group mouse is deprived of food but not water 12h.Blank control group stomach-filling distilled water, component is respectively administered in remaining
Not An 10mL/kg stomach-filling corresponding dosage drug, according to blank group, low dose group, this hair is administered in codeine phosphate group, the present invention
The sequence of bright administration high dose group, the 2 minutes beginning gastric infusions in every two mouse intervals in every group are pressed 1 hour after gastric infusion
Two mouse are put into and are drawn cough device by sequence, and constant pressure is sprayed concentrated ammonia liquor 10 seconds, and record mouse cough incubation period is (from starting to be sprayed to
Cause the time of mouse the 1st time cough) and 2 minutes in there is the number of typical cough, typical cough acts: contraction of abdominal muscle or contracting
Chest, while magnifying mouth, micro- lift has cough sound, and cough person's incubation period, died was not in terms of the positive of coughing in terms of 2 minutes in 2 minutes.
3 results
The present invention can effectively extend mouse cough incubation period (P < 0.05), cough number (P < 0.05) in reduction 2 minutes.Knot
Fruit is shown in Table 1.
Antitussive action result of the drug of the present invention of table 1 to cough mouse model
Compared with blank control group, * P < 0.05, #P < 0.01.
Claims (7)
1. a kind of Chinese medicine composition with cough-relieving function containing Portugal, it is characterised in that by the traditional Chinese medicine of following weight ratio
It forms: Portugal: beautiful millettia root: Chinese pholidota pseudobulb or herb: berchemia lineata=(2-4): (1.5-3): (1.5-3): (1.5-3).
2. the Chinese medicine composition with cough-relieving function according to claim 1 containing Portugal, it is characterised in that by following
The traditional Chinese medicine of weight ratio forms: Portugal: beautiful millettia root: Chinese pholidota pseudobulb or herb: berchemia lineata=(3-4): (2-3): (1.5-2.5): (1.5-
2.5)。
3. the Chinese medicine composition with cough-relieving function according to claim 1 containing Portugal, it is characterised in that by following
The traditional Chinese medicine of weight ratio forms: Portugal: beautiful millettia root: Chinese pholidota pseudobulb or herb: berchemia lineata=4: 3: 1.8: 2.
4. the Chinese medicine composition with cough-relieving function according to claim 1 containing Portugal, it is characterised in that: described
Chinese medicine composition is decoction.
5. a kind of Chinese materia medica preparation with cough-relieving function containing Portugal is with claim 1,2 or 3 Chinese medicine compositions
Extract is effective component, adds preparation made from pharmaceutic adjuvant.
6. the Chinese materia medica preparation with cough-relieving function according to claim 5 containing Portugal, it is characterised in that: the preparation
Dosage form be oral solution, syrup, capsule, tablet, granule, pill or aerosol.
7. the Chinese materia medica preparation with cough-relieving function according to claim 5 containing Portugal, it is characterised in that: the extraction
Object is water extract.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1070114A (en) * | 1992-08-24 | 1993-03-24 | 中山市中药厂 | The prescription of diseases caused by exogenous pathogenic factor herbal tea or electuary and preparation method |
| CN102600312A (en) * | 2012-04-11 | 2012-07-25 | 中山市中智药业集团有限公司 | Medicine composition with effect of preventing influenza |
-
2016
- 2016-05-31 CN CN201610380808.6A patent/CN105943856B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1070114A (en) * | 1992-08-24 | 1993-03-24 | 中山市中药厂 | The prescription of diseases caused by exogenous pathogenic factor herbal tea or electuary and preparation method |
| CN102600312A (en) * | 2012-04-11 | 2012-07-25 | 中山市中智药业集团有限公司 | Medicine composition with effect of preventing influenza |
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