CN107375777A - A kind of cough stopping oral liquor - Google Patents
A kind of cough stopping oral liquor Download PDFInfo
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- CN107375777A CN107375777A CN201710526529.0A CN201710526529A CN107375777A CN 107375777 A CN107375777 A CN 107375777A CN 201710526529 A CN201710526529 A CN 201710526529A CN 107375777 A CN107375777 A CN 107375777A
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- cough
- oral liquid
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- malt
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/17—Gnetophyta, e.g. Ephedraceae (Mormon-tea family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/12—Magnesium silicate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
- A61K36/296—Epimedium
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/483—Gleditsia (locust)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8964—Anemarrhena
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8998—Hordeum (barley)
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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Abstract
The invention provides a kind of oral liquid.Each bulk drug compatibility of the present invention is precise and appropriate, available for treating many coughs of phlegm, particularly cough with lung heat or cough with lung heat and anemofrigid cold, in addition, during using Chinese ephedra suede, it is outstanding to be adapted to treatment children cough;Simultaneously, it is contemplated that the inconvenience of children in use, the oral liquid by the medicine preparation into delicious taste so that infant is easier to receive, and alleviates the situation that infant is reluctant medication.
Description
Technical field
The present invention relates to a kind of cough stopping oral liquor.
Background technology
Cough is the protectiveness respiration reflex action that human body removes secretion or foreign matter in respiratory tract.Although there is its favourable
One side, but acutely chronic cough can cause hemorrhage from respiratory tract.It is correct to distinguish general cough and cough variant asthma, prevent from missing
Examine.Treatment cough should distinguish cough type, and Western medicine, Chinese medicine all may be used.
Doctor trained in Western medicine thinks that cough is mainly caused by the infection of the upper respiratory tract, bronchitis, pneumonia or laryngitis.The traditional Chinese medical science thinks, cough
It is because of the diseases caused by external factors six external factors which cause diseases, internal organs internal injury to cough, and influences the sound disease for having phlegm caused by lung.See《Plain Questions the five internal organs generate a piece》.《Plain Questions disease
Machine gas is preferably saved one's life collection》:" cough meaning it is sound without phlegm, lung qi wound and it is unclear;Coughing is noiseless and has phlegm, and spleen is wet dynamic and is phlegm.Cough
Meaning of coughing has phlegm and sound, lid moved due to wound in lung qi it is wet in spleen, cough and be to cough ".Because exopathogen violates lung, or internal organs internal injury, involve in
Caused by lung.
The medicine of cough-relieving at present is a lot of, but effect is different.But, usually can be bad due to smell for Chinese medicine, and lead
Child patient is caused not to be easily accepted by.The present invention intends providing the oral liquid that a kind of curative effect preferably treats children cough.
The content of the invention
It is an object of the invention to provide a kind of oral liquid for treating children cough and application thereof.
The invention provides a kind of oral liquid, and it is prepared by the following method:
(1)Get it filled by weight ratio material:Honey Chinese ephedra suede 30 ~ 100g semen armeniacae amarae 50 ~ 100g, 120 ~ 170g of gypsum radix glycyrrhizaes 20 ~
70g grass-leaved sweetflag 20 ~ 70g barrenwort 10 ~ 40g fructus gleditsiae 10 ~ 50g talcum 150 ~ 250g, 70 ~ 130g of wind-weed malt 200 ~
50 ~ 100g of the 400g roots of Dahurain angelica;
(2)Above-mentioned medicinal material extracting in water is taken, Aqueous extracts are concentrated under reduced pressure, and it is 70 ~ 80%v/v to add ethanol in proper amount to alcohol content, quiet
Put, filter, filtrate recycling ethanol, filtrate adds 400 ~ 600ml of simple syrup, regulation pH to neutrality, stands, and centrifugation, takes supernatant again
2000ml is added water to, produces oral liquid.
It yet there are no the relevant report of above-mentioned identical pharmaceutical composition.In the present invention, honey Chinese ephedra freeings lung and relieving asthma cough-relieving,
Semen armeniacae amarae expelling phlegm and arresting coughing, gypsum clearing heat and relieving fidgetness are monarch, and grass-leaved sweetflag, the wind-weed, talcum, fructus gleditsiae dissipating phlegm for resuscitation, dry moistening lung, heat-clearing are oozed
Wet is minister, aids in monarch drug in a prescription clearing heat and moistening lung, preventing phlegm from forming and stopping coughing.Found in long therapeutic procedure, the ill unnecessary eating and drinking without temperance of infant, taste
Lack of proper care relevant, therefore, with malt promoting the circulation of qi helps digestion, spleen benefiting and stimulating the appetite in said composition, radix glycyrrhizae is invigorated the spleen and benefited qi, expelling phlegm and arresting coughing is adjutant.
The main apocenosis of invigorating blood circulation of the root of Dahurain angelica, myogenic pain relieving, but guiding drug is used as in the present compositions, priming enters lung, spleen, stomach.All medicines share, altogether
Play clearing heat and moistening lung, relieving cough and reducing sputum work(.
Although above-mentioned medicinal material composition decocting liquid smell relatively easily receives, still there are children during Clinical practice
It is reluctant to use, therefore, in the present invention on the basis of Chinese medical extract, is also added into appropriate simple syrup, allows above-mentioned Chinese medicine to carry
Take thing to exist with the drink form of delicious taste, be more suitable for children taking.
The present invention, it is necessary to extract is simply purified, prevents the later stage from being produced in storage process in preparation process
Precipitation, influences quality.
In oral liquid of the present invention in addition to above-mentioned auxiliary material, other flavourings can also be added, such as sucrose, maltose, thin
Lotus oil etc., but peppermint oil etc. needs to use appropriate solvent to dissolve, and the solvent meets medicinal.
In addition, except flavouring, for the storage requirements of the oral liquid, preservative can also be properly added.
Further, the weight proportion of its bulk drug is as follows:
Honey Chinese ephedra suede 40 ~ 60g semen armeniacae amarae 60 ~ 80g gypsum 140 ~ 160g radix glycyrrhizae 40 ~ 60g grass-leaved sweetflag 40 ~ 60g barrenwort
20 ~ 30g fructus gleditsiae 20 ~ 40g talcum 180 ~ 220g the wind-weed 90 ~ 110g malt 25 ~ 35g roots of Dahurain angelica, 6 ~ 8g.
Further, the weight proportion of its bulk drug is as follows:
Honey Chinese ephedra suede 50g semen armeniacae amarae 70 ~ 80g gypsum 150g radix glycyrrhizae 50g grass-leaved sweetflag 50g barrenwort 20 ~ 30g fructus gleditsiaes
70 ~ 80g of the 30g talcum 200g wind-weed 100g malt 300g roots of Dahurain angelica.
Wherein, the Chinese ephedra is honey Chinese ephedra, and the malt is coloured malt.
So-called honey Chinese ephedra, also known as Herba ephedrae, the warm-natured profit partially of Herba ephedrae, pungent scattered perspiration relax, and effect is enhancing
Moisten the lung and relieve the cough, with cough-relieving power victory of freeinging lung and relieving asthma.
Coloured malt, cure mainly dyspepsia, abdominal distention, spleen eating less.
Numb suede is exactly Chinese ephedra suede, and Chinese medicine Chinese ephedra is ground into suede, primarily to relaxing the power of the sweating of Chinese ephedra, is more suitable for
Old man, child and physically weak person's anemofrigid cold.Usage, effect are similar to Chinese ephedra.If herein using Chinese ephedra suede, the pharmaceutical composition
It can be exclusively used in treating old man or children cough.
Present invention also offers purposes of the above-mentioned oral liquid in children's cough suppressing medicine is prepared.
Further, the medicine is the medicine for treating many coughs of phlegm.
Further, the medicine is treatment cough with lung heat or the medicine of cough with lung heat and anemofrigid cold.
Each bulk drug compatibility of the present invention is precise and appropriate, available for treating many coughs of phlegm, particularly cough with lung heat or cough with lung heat is simultaneous
Anemofrigid cold, in addition, during using Chinese ephedra suede, it is outstanding to be adapted to treatment children cough;Simultaneously, it is contemplated that children are in use not
Just, the oral liquid by the medicine preparation into delicious taste so that infant is easier to receive, and alleviates the feelings that infant is reluctant medication
Condition.
In addition, for the higher paste of viscosity, the mobility of oral liquid is more preferable, and children's use is more convenient.
Embodiment
The preparation of 1 oral liquid of the present invention of embodiment
(1)Get it filled by weight ratio material:Honey Chinese ephedra suede 50g semen armeniacae amarae 75g gypsum 150g radix glycyrrhizae 50g grass-leaved sweetflags 50g is excessive
Sheep leaves of pulse plants 25g fructus gleditsiae 30g talcum 200g wind-weed 100g malt 300g roots of Dahurain angelica 75g;
(2)Above-mentioned medicinal material extracting in water is taken, Aqueous extracts are concentrated under reduced pressure, and it is 75%v/v to add ethanol in proper amount to alcohol content, stand, mistake
Filter, filtrate recycling ethanol, filtrate add simple syrup 500ml, regulation pH to neutrality, stand, centrifugation, take supernatant add water to
2000ml, produce oral liquid.
Gained oral liquid of the invention, dark-brown, gas is fragrant, and sweet, mouthfeel smell is good.
The preparation of 2 oral liquid of the present invention of embodiment
(1)Get it filled by weight ratio material:Honey Chinese ephedra suede 50g semen armeniacae amarae 70g gypsum 150g radix glycyrrhizae 50g grass-leaved sweetflags 50g is excessive
Sheep leaves of pulse plants 30g fructus gleditsiae 30g talcum 200g wind-weed 100g malt 300g roots of Dahurain angelica 80g;
(2)Above-mentioned medicinal material extracting in water is taken, Aqueous extracts are concentrated under reduced pressure, and it is 70%v/v to add ethanol in proper amount to alcohol content, stand, mistake
Filter, filtrate recycling ethanol, filtrate add simple syrup 400ml, regulation pH to neutrality, stand, centrifugation, take supernatant add water to
2000ml, produce oral liquid.
Beneficial effect:
Pharmaceutical composition of the present invention treats the example of children with cough more than 300 altogether so far, and mostly cough with lung heat person uses the drug regimen
Thing, most infant coughing with a lot of sputum, cough sooner or later serious, most of patient has no heating paresthesia, occasionally has flavour of a drug agent in therapeutic process
Amount adjustment, but in scope of medication of the present invention.Its therapeutic modality and effect are as follows:
Oral liquid bulk drug of the present invention(It is formulated A):Honey Chinese ephedra suede 5g semen armeniacae amarae 7.5g gypsum 15g radix glycyrrhizae 5g grass-leaved sweetflags 5g
Barrenwort 2.5g fructus gleditsiae 3g talcum 20g wind-weed 10g malt 30g roots of Dahurain angelica 7.5g.
It is formulated B:Semen armeniacae amarae 7.5g, coix seed 15g, cardamom 7.5g, bark of official magnolia 7.5g, talcum 20g, rhizoma pinellinae praeparata 5g, radix glycyrrhizae 5g,
Radix cynanchi wilfordii 15g, root bark of white mulberry 15g, root bark of Chinese wolf-berry 10g, root of Herba Gonostegiae hirtae 15g.
Accept cough with lung heat's infant 306 for medical treatment altogether at present, majority is many coughs of phlegm, and Cough length is more than 2 week.First with formula A
One one, and altogether using 3 ~ 4 days, it is one to reuse formula B mono- day, uses 3 ~ 4 days.Using the above method, cured in 1 week
Rate reaches 80%, and symptom mitigation rate is up to 99% in 1 week.According to investigations, if diet control is proper, infant typically can be at 1-2
Fully recover in week, if eating is raw and cold, scorching food, illness repeatedly, after advising its parent to keep on a diet, substantially can in 1 week
Recovery from illness.
In addition, after formula A is used alone, symptom mitigation rate is up to 90% in infant 1 week of medication, and infant phlegm is obvious
Tail off, cough frequency reduces, then can obtain recovery from illness with the use of formula B.Some infants are after formula A has been taken, without using formula
B, but use ammonia bromine spy sieve's oral administration solution(Per ml ambroxol-hydrochloride-containing 1.5mg, the μ g of Clenizole Hydrochloride 1), equally can be
Cured in 1-2 week, still, by investigation, it was also found that most infants are just directly put down without formula A treatments using cough-relieving
Breathe heavily syrup(Good reach is relaxed)+ ammonia bromine spy sieve's oral administration solution, symptom has mitigation, but can not still be fully recovered using 2-3 week, it is possible thereby to
The importance of pharmaceutical composition of the present invention is learnt in contrast.
Claims (7)
- A kind of 1. oral liquid, it is characterised in that:It is prepared by the following method:(1)Get it filled by weight ratio material:Honey Chinese ephedra suede 30 ~ 100g semen armeniacae amarae 50 ~ 100g, 120 ~ 170g of gypsum radix glycyrrhizaes 20 ~ 70g grass-leaved sweetflag 20 ~ 70g barrenwort 10 ~ 40g fructus gleditsiae 10 ~ 50g talcum 150 ~ 250g, 70 ~ 130g of wind-weed malt 200 ~ 50 ~ 100g of the 400g roots of Dahurain angelica;(2)Above-mentioned medicinal material extracting in water is taken, Aqueous extracts are concentrated under reduced pressure, and it is 70 ~ 80%v/v to add ethanol in proper amount to alcohol content, quiet Put, filter, filtrate recycling ethanol, filtrate adds 400 ~ 600ml of simple syrup, regulation pH to neutrality, stands, and centrifugation, takes supernatant again 2000ml is added water to, produces oral liquid.
- 2. oral liquid according to claim 1, it is characterised in that:The weight proportion of each medicinal material is as follows:Honey Chinese ephedra suede 40 ~ 60g semen armeniacae amarae 60 ~ 80g gypsum 140 ~ 160g radix glycyrrhizae 40 ~ 60g grass-leaved sweetflag 40 ~ 60g barrenwort 20 ~ 30g fructus gleditsiae 20 ~ 40g talcum 180 ~ 220g the wind-weed 90 ~ 110g malt 25 ~ 35g roots of Dahurain angelica, 6 ~ 8g.
- 3. oral liquid according to claim 2, it is characterised in that:The weight proportion of its bulk drug is as follows:Honey Chinese ephedra suede 50g semen armeniacae amarae 70 ~ 80g gypsum 150g radix glycyrrhizae 50g grass-leaved sweetflag 50g barrenwort 20 ~ 30g fructus gleditsiaes 70 ~ 80g of the 30g talcum 200g wind-weed 100g malt 300g roots of Dahurain angelica.
- 4. according to oral liquid described in claim 1-3 any one, it is characterised in that:The malt is coloured malt.
- 5. purposes of the oral liquid described in claim 1-4 any one in children's cough suppressing medicine is prepared.
- 6. purposes according to claim 5, it is characterised in that:The medicine is the medicine for treating many coughs of phlegm.
- 7. purposes according to claim 5, it is characterised in that:The medicine is treatment cough with lung heat or cough with lung heat and wind The medicine of cold flu.
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CN201710526529.0A CN107375777A (en) | 2017-06-30 | 2017-06-30 | A kind of cough stopping oral liquor |
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CN201710526529.0A CN107375777A (en) | 2017-06-30 | 2017-06-30 | A kind of cough stopping oral liquor |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109276625A (en) * | 2018-10-25 | 2019-01-29 | 济川药业集团有限公司 | A kind of Huanglong's cough and asthma syrup and preparation method thereof |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN101041001A (en) * | 2007-04-24 | 2007-09-26 | 刘舒亚 | Medicine for treating cough and asthma and removing phlegm and the method for preparing the oral liquid thereof |
CN102038776A (en) * | 2010-12-10 | 2011-05-04 | 宁夏多维药业有限公司 | Oral liquid capable of relieving cough and asthma and preparation method thereof |
-
2017
- 2017-06-30 CN CN201710526529.0A patent/CN107375777A/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101041001A (en) * | 2007-04-24 | 2007-09-26 | 刘舒亚 | Medicine for treating cough and asthma and removing phlegm and the method for preparing the oral liquid thereof |
CN102038776A (en) * | 2010-12-10 | 2011-05-04 | 宁夏多维药业有限公司 | Oral liquid capable of relieving cough and asthma and preparation method thereof |
Non-Patent Citations (2)
Title |
---|
张凡等: "哮喘灵治疗小儿哮喘发作期315例临床观察", 《四川中医》 * |
陈慧肃等: "清肺糖浆的制备及临床疗效观察", 《中国药师》 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109276625A (en) * | 2018-10-25 | 2019-01-29 | 济川药业集团有限公司 | A kind of Huanglong's cough and asthma syrup and preparation method thereof |
CN109276625B (en) * | 2018-10-25 | 2021-06-04 | 济川药业集团有限公司 | Huanglong cough and asthma syrup and preparation method thereof |
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