CN101664461B - Pharmaceutical composition for treating cough - Google Patents
Pharmaceutical composition for treating cough Download PDFInfo
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- CN101664461B CN101664461B CN2009103074487A CN200910307448A CN101664461B CN 101664461 B CN101664461 B CN 101664461B CN 2009103074487 A CN2009103074487 A CN 2009103074487A CN 200910307448 A CN200910307448 A CN 200910307448A CN 101664461 B CN101664461 B CN 101664461B
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Abstract
The invention discloses a pharmaceutical composition for treating cough, which comprises the following effective raw medicines by weight portions: 5-20 of Chinese ephedra, 5-20 of poppy shell, 100-300 of semen armeniacae amarae, 100-300 of liquorice, 20-100 of raphanus satlvus linne, 20-100 of ballonflower and 30-100 of gypsum. The medicament has the efficacies of dispersing lung and clearing away heat, relieving cough and preventing asthma, and has certain effects on the diseases such as upper respiratory tract infection, tracheitis, pneumonia, cough and the like. The formula of the pharmaceutical composition reduces the contents of Chinese ephedra and poppy shell and achieves the same treatment effect with Keke capsules, namely the excitatory effect generated by the Chinese ephedra and poppy shell is greatly reduced under the premise of ensuring the efficacy, thus improving the medicament safety and achieving the goal of the invention.
Description
Technical field:
The present invention relates to a kind of pharmaceutical composition for the treatment of cough, belong to field of pharmaceutical technology.
Background technology:
Respiratory system disease is one of disease kind of being familiar with of people, mostly is commonly encountered diseases and frequently-occurring disease such as flu, cough, bronchitis, asthma etc.Respiratory system disease occurs in human respiratory tract's (comprising throat, trachea, bronchus and pulmonary), and to cough, expectorant, to breathe heavily, scorching be its common characteristic, inflammation then is the cause of disease, coughs, expectorant, to breathe heavily be the symptom of secondary.These symptoms influence patient's rest and health, if do not heal for a long time, also may develop into emphysema, bronchiectasis and pulmonary heart disease etc.
KEKE JIAONANG is to develop on the MAXINGSHIGAN TANG basis of China's traditional Chinese medical science famous classic treatise on Febrile Diseases, is total to seven flavor medicine by Herba Ephedrae, Pericarpium Papaveris, Radix Glycyrrhizae, Semen Armeniacae Amarum, Semen Raphani, Radix Platycodonis, Gypsum Fibrosum and forms; Having cough-relieving, Dingchuan, expectorant effect, is one of safe and effective medicine of treatment various coughs, acute/chronic bronchitis, bronchial asthma, old cough with asthma.Be applicable to diseases such as sense cough, bronchial asthma, acute/chronic bronchitis, pharyngolaryngitis, the excessive cough that causes of smoking, old cough with asthma.
But owing to contain narcoticness medicine Pericarpium Papaveris in the KEKE JIAONANG, can produce the ephedrine of mental excitation effect in addition in addition, take for a long time, particularly arbitrarily not strengthen dosage in accordance with regulations, very likely produce dependency and addiction.At present, existing many patients are the purpose that reaches temporary transient excitement, and by taking the medicine that contains ephedrine and Pericarpium Papaveris in a large number for a long time, the result causes the bibliographical information of codeine, ephedrine chronic poisoning.Therefore, how in the safety that guarantees to increase under the constant prerequisite of product curative effect medicine, become one and need to be resolved hurrily and significant research topic.
Summary of the invention:
The objective of the invention is to: a kind of pharmaceutical composition for the treatment of cough is provided.The present invention is directed to existing cough stopping formulation and easily produce dependency, addicted problem, through series of experimental research, under the prerequisite that guarantees curative effect of medication, adjusted the consumption of each crude drug, reduce the usage ratio of Herba Ephedrae and Pericarpium Papaveris, effectively improved the safety of medicine.
The present invention constitutes like this: a kind of pharmaceutical composition for the treatment of cough, calculate according to composition by weight: it is that effective crude drug is made with Herba Ephedrae 5-20, Pericarpium Papaveris 5-20, Semen Armeniacae Amarum 100-300, Radix Glycyrrhizae 100-300, Semen Raphani 20-100, Radix Platycodonis 20-100 and Gypsum Fibrosum 30-100.
Calculate according to composition by weight, aforementioned pharmaceutical composition preferably adopts Herba Ephedrae 15, Pericarpium Papaveris 15, Semen Armeniacae Amarum 180, Radix Glycyrrhizae 180, Semen Raphani 56, Radix Platycodonis 56 and Gypsum Fibrosum 60 to make for effective crude drug.
Above-described pharmaceutical composition can be all preparations that medically allow, and comprises oral formulations, ejection preparation.
Described oral formulations comprises capsule, granule, pill, tablet, oral liquid.
Described ejection preparation comprises injection, freeze-dried powder, infusion solutions.
The preparation of drug combination technology of treatment cough of the present invention is: Herba Ephedrae and Pericarpium Papaveris are partly pulverized, and residue Herba Ephedrae and Pericarpium Papaveris coarse powder decoct with acidic aqueous solution, filter, and filtrate is transferred pH value to 7, and medicinal liquid is standby; All the other Radix Glycyrrhizaes, Semen Armeniacae Amarum, Semen Raphani, Radix Platycodonis, Gypsum Fibrosum decoct with water, and filter, and filtrate and above-mentioned medicinal liquid merge, and are concentrated into the thick paste shape, add Herba Ephedrae and Pericarpium Papaveris fine powder, mix with adjuvant again, make different preparations with conventional method.
Concrete preparation technology is: the 10-90% of Herba Ephedrae and Pericarpium Papaveris recipe quantity is ground into fine powder more than 80 orders, residue Herba Ephedrae and Pericarpium Papaveris coarse powder transfer the acidic aqueous solution about pH value to 5 to decoct 1-5 time with 10% hydrochloric acid, each 0.5-3 hour, filter, filtrate is transferred pH value to 7 with 10% sodium hydroxide solution, and medicinal liquid is standby; All the other Radix Glycyrrhizaes, Semen Armeniacae Amarum, Semen Raphani, Radix Platycodonis, Gypsum Fibrosum decoct with water 1-5 time, and each 0.5-3 hour, filter, filtrate and above-mentioned medicinal liquid merge, be concentrated into the thick paste shape, add Herba Ephedrae and Pericarpium Papaveris fine powder, drying, pulverize, mix with adjuvant again, make different preparations with conventional method.
The pharmaceutical composition of treatment cough of the present invention can also prepare like this: Herba Ephedrae, Pericarpium Papaveris are pulverized the back and are extracted with semi-biomimetic method, Semen Armeniacae Amarum steams earlier, Radix Glycyrrhizae, Semen Raphani, Radix Platycodonis, Gypsum Fibrosum are soaked, extract with Semen Armeniacae Amarum water decocting method then, merge with Herba Ephedrae, Pericarpium Papaveris extracting solution behind the extracting liquid filtering, concentrating under reduced pressure becomes extractum, adds different adjuvants again, makes different preparations with conventional method.
Concrete preparation technology is: Herba Ephedrae, Pericarpium Papaveris are pulverized, and add the hydrochloric acid solution that 3-30 doubly measures PH 2-4, soak after 0.5-5 hour to decoct 1-5 time, the hydrochloric acid solution of the PH 2-4 that each 3-30 of adding doubly measures decocted 0.5-3 hour, filter, merging filtrate transfers PH to 6.0-8.0 standby; Semen Armeniacae Amarum steamed 5-500 minute earlier, Radix Glycyrrhizae, Semen Raphani, Radix Platycodonis, Gypsum Fibrosum add 3-30 times of water gaging and soaked 0.5-5 hour, decoct 1-5 time with Semen Armeniacae Amarum then, the decocting that each adding 3-30 doubly measures boiled 0.5-5 hour, filter, filtrate and Herba Ephedrae, Pericarpium Papaveris extracting solution merge, and concentrating under reduced pressure becomes extractum, add different adjuvants again, make different preparations with conventional method.
In order to realize purpose of the present invention, reduce the content of cough stopping formulation epheday intermedia and Pericarpium Papaveris, increase the safety of this medicine, the inventor has carried out long-term a large amount of experimentation.In effect experiment research, find, only reduce the content of medicine epheday intermedia and Pericarpium Papaveris, the effect of its treatment cough also decreases, how could guarantee the curative effect of medicine? the inventor finds through test of many times, suitably increase the consumption of all the other crude drug (except Herba Ephedrae and the Pericarpium Papaveris), when reaching prescription ratio of the present invention, can effectively guarantee the curative effect of this pharmaceutical preparation.
Below be the Pharmacodynamic test of active extract that the inventor carried out:
Preparation cough-relieving of the present invention, reduce phlegm, relieving asthma and immunization research:
One, material:
1, medicine: KEKE JIAONANG: commercially available, lot number: 20090102.
Capsule of the present invention: preparation according to the method described in the present invention.
2, animal: Cavia porcellus, NIH mice, SD rat provide by Guiyang Medical College.
Two, experimental technique and result
1, cough-relieving experiment: get 36 of NIH mices, male and female half and half are divided into 3 groups at random, are respectively matched group, KEKE JIAONANG group, Capsules group of the present invention.Each administration group is gastric infusion 20ml/kg according to dosage, and matched group gives the equal-volume distilled water, every day 1 time, 3d continuously.1h after the last administration puts into sprayer unit with mice and begins to accept spraying, the cough latent period of record mice, and calculate the cough-relieving rate:
Cough-relieving rate %=(administration group cough response time/matched group cough response time) * 100%
The result: Capsules group of the present invention is compared with the KEKE JIAONANG group, and mouse cough incubation period and cough-relieving rate are suitable, compares P＜0.05 with matched group.See following table for details:
| Group | Dosage (the g crude drug/kg) | Cough latent period (s) | Cough-relieving rate (%) |
| Matched group | - | 18.66±4.03 | - |
| The KEKE JIAONANG group | 5.4 | 32.65±11.17 | 178.8 |
| Capsules group of the present invention | 5.4 | 33.11±12.08 | 179.5 |
2, the experiment of reducing phlegm: capillary glass-tube method, get 30 of SD rats, male and female half and half are divided into 3 groups at random, are respectively matched group, KEKE JIAONANG group, Capsules group of the present invention.Water 12h is can't help in fasting before each group experiment, urethane 1g/kg intraperitoneal injection of anesthesia, it is fixing to face upward the position, cut off neck middle part skin, isolate trachea, hit exactly between two cartilages at thyroid cartilage lower edge and prick an aperture with sharp-pointed injection needle, insert one of internal diameter 0.8cm capillary glass tube then, make capillary tube just contact the trachea lower surface,, draw sputum length as the effect of reducing phlegm of estimating medicine with capillary tube so as to drawing the sputum at trachea rear portion.After the normal secretory volume of 1h, each administration group is gastric infusion 20ml/kg according to dosage before the record administration, and matched group gives the equal-volume distilled water, and record administration 1h respectively organizes the sputum secretory volume of rat.
The result: the sputum secretory volume of Capsules group rat of the present invention is suitable with the KEKE JIAONANG group; Compare P＜0.01 with matched group.See following table for details:
| Group | Dosage (the g/ crude drug/kg) | The normal secretory volume of sputum (cm) | Secretory volume behind the sputum medicine (cm) |
| Matched group | - | 2.06±0.18 | 2.16±0.13 |
| The KEKE JIAONANG group | 5.4 | 2.16±0.20 | 2.98±0.22 |
| Capsules group of the present invention | 5.4 | 2.15±0.18 | 3.10±0.19 |
3, the experiment of relievining asthma: spraying causes the method for breathing heavily, and gets 30 of Cavia porcelluss, and male and female half and half are divided into 3 groups at random, are respectively matched group, KEKE JIAONANG group, Capsules group of the present invention.Each administration group is gastric infusion 20ml/kg according to dosage, and matched group gives the equal-volume distilled water, every day 1 time, 3d continuously.1h after the last administration by only Cavia porcellus being placed in the device case, starts the WH-96 ultrasound atomizer, sprays into the 1mg/ml histamine phosphate, pick up counting simultaneously, record from spraying begin to time that Cavia porcellus twitches as asthma incubation period, and calculate the asthma suppression ratio.
The result: Capsules group Cavia porcellus of the present invention is suitable with the KEKE JIAONANG group asthma incubation period, compares P＜0.01 with matched group.See following table for details:
| Group | Dosage (the g crude drug/kg) | Asthma incubation period (min) | Asthma suppression ratio (%) |
| Matched group | - | 2.14±0.48 | - |
| The KEKE JIAONANG group | 5.4 | 2.60±0.55 | 117.8 |
| Capsules group of the present invention | 5.4 | 2.65±0.49 | 119.2 |
4, immunization experiment: get 36 of NIH mices, male and female half and half are divided into 3 groups at random, are respectively matched group, KEKE JIAONANG group, Capsules group of the present invention.Each administration group is gastric infusion 20ml/kg according to dosage, and matched group gives the equal-volume distilled water, every day 1 time, 7d continuously.1h after the last administration takes off cervical vertebra and puts to death mice, wins and respectively organizes mouse thymus and spleen, in BA61 type electronic-weighing, calculates mouse thymus exponential sum index and spleen index.
The result: Capsules group mouse thymus index of the present invention and index and spleen index are suitable with the KEKE JIAONANG group, compare thymus index P＜0.01, index and spleen index P＜0.05 with matched group.See following table for details:
| Group | Dosage (the g crude drug/kg) | Thymus index (mg/g) | Index and spleen index (mg/g) |
| Matched group | - | 1.255±0.378 | 3.298±0.495 |
| The KEKE JIAONANG group | 5.4 | 1.859±0.455 | 3.987±0.924 |
| Capsules group of the present invention | 5.4 | 1.865±0.421 | 4.088±0.878 |
Above-mentioned experiment shows: the cough-relieving of Capsules group of the present invention, reduce phlegm, relieving asthma and immunization suitable with KEKE JIAONANG.
Preparation of the present invention is to the influence of mice crawler behavior:
One, material:
1, medicine: cough-relieving injection: get the KEKE JIAONANG prescription, prepare according to the method for the invention.
Injection of the present invention: prepare according to the method for the invention.
2, animal: mice is provided by Guiyang Medical College.
Two, experimental technique and result
1, to the influence of mice outward appearance behavioral activity
Mice is divided into 7 groups (10 every group) at random, and lumbar injection cough-relieving injection and injection of the present invention and normal saline compare the outward appearance behavioral activity that mice is respectively organized in the administration front and back respectively.As a result, after mice was given normal saline, behavioral activity did not have significant change; After giving the cough-relieving injection, the activity that each dosage treated animal shows in various degree increases, and with perpendicular hair, easily enrages; And injection group of the present invention only the maximal dose group just the appearance activity increase and a perpendicular hair symptom.
2, to the influence of mice autonomic activities
Mice is divided into 7 groups (10 every group) at random, respectively lumbar injection cough-relieving injection and injection of the present invention and normal saline.15min after the administration adopts the photoelectric counting instrument to observe the autonomic activities number of mice in the 10min.(x ± s) expression makes the t significance test to data, the results are shown in following table with average ± standard deviation.
Preparation of the present invention is to the influence of mice autonomic activities
| Group | Dosage (mlkg -1) | Autonomic activities number (inferior min -1) |
| The NS matched group | 0 | 16.79±10.35 |
| Cough-relieving injection group | 10ml/kg | 36.90±13.21* |
| Cough-relieving injection group | 20ml/kg | 45.41±18.55** |
| Cough-relieving injection group | 30ml/kg | 58.29±20.58** |
| Injection group of the present invention | 10ml/kg | 15.81±11.23▲ |
| Injection group of the present invention | 20ml/kg | 16.45±13.17▲▲ |
| Injection group of the present invention | 30ml/kg | 20.14±10.78▲▲ |
Cough-relieving injection group is compared with matched group, * P＜0.05, * * P＜0.01.
Injection group of the present invention with compare with dosage cough-relieving injection group, ▲ P＜0.05, ▲ ▲ P＜0.01.
Three, conclusion
Give mice cough-relieving injection and injection of the present invention Deng dosage, injection group of the present invention is far smaller than cough-relieving injection group to the influence of mice crawler behavior.
Compared with prior art: medicine provided by the present invention has the lung qi dispersing heat clearing away, cough-relieving, the effect of relievining asthma, and to upper respiratory tract infection, tracheitis, pneumonia, diseases such as cough have definite curative effect; And reduced the content of Herba Ephedrae and Pericarpium Papaveris in the pharmaceutical preparation of the present invention prescription, but can reach the therapeutic effect identical with KEKE JIAONANG, promptly under the prerequisite that guarantees curative effect of medication, significantly reduced the excitation that Herba Ephedrae and Pericarpium Papaveris are produced, improve the safety of medicine, reached the purpose of invention.
The specific embodiment:
Embodiments of the invention 1: get Herba Ephedrae 15g, Pericarpium Papaveris 15g, Semen Armeniacae Amarum 180g, Radix Glycyrrhizae 180g, Semen Raphani 56g, Radix Platycodonis 56g, Gypsum Fibrosum 60g; Herba Ephedrae and each 10g of Pericarpium Papaveris are ground into fine powder about 100 orders, residue Herba Ephedrae and Pericarpium Papaveris coarse powder transfer the acidic aqueous solution about pH value to 5 to decoct 3 times with 10% hydrochloric acid, 2 hours for the first time, each 1 hour of second and third time, filter, filtrate is transferred pH value to 7 with 10% sodium hydroxide solution, and medicinal liquid is standby; All the other Radix Glycyrrhizaes, Semen Armeniacae Amarum, Semen Raphani, Radix Platycodonis, Gypsum Fibrosum decoct with water 3 times, each 1 hour, filter, filtrate and above-mentioned medicinal liquid merge, be concentrated into the thick paste shape, add Herba Ephedrae and Pericarpium Papaveris fine powder and microcrystalline Cellulose, mixing, 60-70 ℃ of drying, be ground into fine powder or make granule, incapsulate, make 1000, every 0.3g promptly gets capsule.
Usage and consumption: oral, one time 3,2 times on the one.
Embodiments of the invention 2: get Herba Ephedrae 5g, Pericarpium Papaveris 5g, Semen Armeniacae Amarum 100g, Radix Glycyrrhizae 100g, Semen Raphani 20g, Radix Platycodonis 20g, Gypsum Fibrosum 30g; Herba Ephedrae and each 3g of Pericarpium Papaveris are ground into 80 purpose fine powders, and residue Herba Ephedrae and Pericarpium Papaveris coarse powder transfer the acidic aqueous solution about pH value to 5 to decoct 5 times with 10% hydrochloric acid, and each 0.5 hour, filter, filtrate is transferred pH value to 7 with 10% sodium hydroxide solution, and medicinal liquid is standby; All the other Radix Glycyrrhizaes, Semen Armeniacae Amarum, Semen Raphani, Radix Platycodonis, Gypsum Fibrosum decoct with water 5 times, each 0.5 hour, filter, filtrate and above-mentioned medicinal liquid merge, and are concentrated into the thick paste shape, add Herba Ephedrae and Pericarpium Papaveris fine powder and microcrystalline Cellulose and magnesium stearate mix homogeneously, tabletting, make 100, every 0.5g promptly gets tablet.
Usage and consumption: oral, one time 1,3 times on the one.
Embodiments of the invention 3: get Herba Ephedrae 20g, Pericarpium Papaveris 20g, Semen Armeniacae Amarum 300g, Radix Glycyrrhizae 300g, Semen Raphani 80g, Radix Platycodonis 80g, Gypsum Fibrosum 100g; Herba Ephedrae and each 5g of Pericarpium Papaveris are ground into 100 purpose fine powders, and residue Herba Ephedrae and Pericarpium Papaveris coarse powder transfer the acidic aqueous solution about pH value to 5 to decoct 3 hours with 10% hydrochloric acid, filter, and filtrate is transferred pH value to 7 with 10% sodium hydroxide solution, and medicinal liquid is standby; All the other Radix Glycyrrhizaes, Semen Armeniacae Amarum, Semen Raphani, Radix Platycodonis, Gypsum Fibrosum decoct with water 3 hours, filter, and filtrate and above-mentioned medicinal liquid merge, and are concentrated into the thick paste shape, add Herba Ephedrae and Pericarpium Papaveris fine powder and cane sugar powder mix homogeneously, make granule.
Usage and consumption: take a 15～30g, 3 times on the one after mixing it with hot water.
Embodiments of the invention 4: get Herba Ephedrae 5g, Pericarpium Papaveris 20g, Semen Armeniacae Amarum 300g, Radix Glycyrrhizae 100g, Semen Raphani 20g, Radix Platycodonis 20g, Gypsum Fibrosum 100g; Herba Ephedrae, Pericarpium Papaveris are pulverized, and add the hydrochloric acid solution of 3 times of amount PH 2-4, soak after 5 hours to decoct 5 times, and the hydrochloric acid solution that at every turn adds the PH 2-4 of 3 times of amounts decocted 3 hours, filtered, and merging filtrate transfers PH to 6.0-8.0 standby; Semen Armeniacae Amarum steamed 500 minutes earlier, Radix Glycyrrhizae, Semen Raphani, Radix Platycodonis, Gypsum Fibrosum add 3 times of water gagings and soaked 5 hours, decoct 5 times with Semen Armeniacae Amarum then, each decocting that adds 3 times of amounts boiled 5 hours, filtered, and filtrate and Herba Ephedrae, Pericarpium Papaveris extracting solution merge, concentrating under reduced pressure becomes extractum, ethanol precipitation with 60%, supernatant reclaims ethanol, and is condensed into thick paste; Other gets sucrose and adds and to make dissolving in the water boil evenly, filters, and makes simple syrup; Simple syrup is added in the above-mentioned thick paste, add sodium benzoate simultaneously, about heating in water bath to 45 ℃, keep this temperature, stir and add 1% chitin hydrochloric acid solution down, continue to stir 20min, filter, get supernatant and add water to 1000ml, fill promptly gets syrup.
Usage and consumption: oral, a 15ml, 3 times on the one.
Embodiments of the invention 5: get Herba Ephedrae 20g, Pericarpium Papaveris 5g, Semen Armeniacae Amarum 100g, Radix Glycyrrhizae 100g, Semen Raphani 100g, Radix Platycodonis 100g, Gypsum Fibrosum 100g; Herba Ephedrae, Pericarpium Papaveris are pulverized, and add the hydrochloric acid solution of 30 times of amount PH 2-4, soak after 0.5 hour to decoct 1 time, and the hydrochloric acid solution that adds the PH 2-4 of 30 times of amounts decocted 0.5 hour, filtered, and merging filtrate transfers PH to 6.0-8.0 standby; Semen Armeniacae Amarum steamed 5 minutes earlier, and Radix Glycyrrhizae, Semen Raphani, Radix Platycodonis, Gypsum Fibrosum add 30 times of water gagings and soaked 0.5 hour, decoct 1 time with Semen Armeniacae Amarum then, each decocting that adds 30 times of amounts boiled 0.5 hour, filtered, and filtrate and Herba Ephedrae, Pericarpium Papaveris extracting solution merge, concentrating under reduced pressure becomes extractum, put cold after, adding ethanol is 60% to containing the alcohol amount, left standstill 18 hours, and filtered filtrate recycling ethanol, continue to be condensed into thick paste, it is an amount of to add water, cold preservation 72 hours, filter filtrate for later use; Other gets sucrose and adds and to make dissolving in the water boil evenly, filters, and makes simple syrup; Simple syrup is added in the standby filtrate, add sodium benzoate, boil dissolving, add water to 1000ml, transfer PH to 5.00-5.25 with sodium hydroxide, stir evenly, filter, embedding promptly gets oral liquid.
Usage and consumption: oral, a 15ml, 3 times on the one.
Embodiments of the invention 6: get Herba Ephedrae 20g, Pericarpium Papaveris 5g, Semen Armeniacae Amarum 100g, Radix Glycyrrhizae 200g, Semen Raphani 20g, Radix Platycodonis 60g, Gypsum Fibrosum 50g; Above seven flavor medicine is ground into fine powder, sieves, mixing is used water pill, and drying promptly gets pill.Usage and consumption: oral, one time 4,3 times on the one.
Embodiments of the invention 7: get Herba Ephedrae 15g, Pericarpium Papaveris 15g, Semen Armeniacae Amarum 200g, Radix Glycyrrhizae 250g, Semen Raphani 80g, Radix Platycodonis 80g, Gypsum Fibrosum 100g; Herba Ephedrae, Pericarpium Papaveris are pulverized, and add 10 times of amount PH and be 3 hydrochloric acid solution, soak after 3 hours to decoct 3 times, and the PH that at every turn adds 10 times of amounts is that 3 hydrochloric acid solution decocted 1.5 hours, filtration, and merging filtrate, PH to 7 is standby for accent; Semen Armeniacae Amarum steamed 50 minutes earlier, Radix Glycyrrhizae, Semen Raphani, Radix Platycodonis, Gypsum Fibrosum add 10 times of water gagings and soaked 3 hours, decoct 3 times with Semen Armeniacae Amarum then, each decocting that adds 10 times of amounts boiled 1 hour, filter, filtrate and Herba Ephedrae, Pericarpium Papaveris extracting solution merge, and concentrating under reduced pressure becomes extractum, twice of the ethanol precipitation with 75%, supernatant reclaims ethanol, and being condensed into thick paste, lyophilization is ground into 80 purpose fine powders again, add dissolving of injection water and embedding in corresponding container, 115 ℃ of pressure sterilizings 2 times each 30 minutes, are prepared into injection.
Usage and consumption: intramuscular injection, a 2～4ml, 1～2 time on the one.
Claims (5)
1. pharmaceutical composition for the treatment of cough is characterized in that: it is that to use Herba Ephedrae 5-20, Pericarpium Papaveris 5-20, Semen Armeniacae Amarum 100-300, Radix Glycyrrhizae 100-300, Semen Raphani 20-100, Radix Platycodonis 20-100 and Gypsum Fibrosum 30-100 according to the weight meter be that effective crude drug is made.
2. according to the pharmaceutical composition of the described treatment of claim 1 cough, it is characterized in that: it is to use Herba Ephedrae 15 according to the weight meter, Pericarpium Papaveris 15, Semen Armeniacae Amarum 180, Radix Glycyrrhizae 180, Semen Raphani 56, Radix Platycodonis 56 and Gypsum Fibrosum 60 to make for effective crude drug.
3. according to the pharmaceutical composition of claim 1 or 2 described treatment coughs, it is characterized in that: described pharmaceutical composition is oral formulations or ejection preparation.
4. according to the pharmaceutical composition of the described treatment cough of claim 3, it is characterized in that: described oral formulations is capsule, granule, pill, tablet or oral liquid.
5. according to the pharmaceutical composition of the described treatment cough of claim 3, it is characterized in that: described ejection preparation is injection, freeze-dried powder or infusion solutions.
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| CN105497712A (en) * | 2015-12-21 | 2016-04-20 | 贵州瑞和制药有限公司龙里药厂 | Manufacturing method of cough and asthma treating preparation |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1557431A (en) * | 2004-01-18 | 2004-12-29 | 贵州益佰制药股份有限公司 | Cough resisting prescription and its preparing process |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1557431A (en) * | 2004-01-18 | 2004-12-29 | 贵州益佰制药股份有限公司 | Cough resisting prescription and its preparing process |
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