CN101485822B - Chinese medicine with phlegm-resolving and cough-suppressing functions and preparation method thereof - Google Patents
Chinese medicine with phlegm-resolving and cough-suppressing functions and preparation method thereof Download PDFInfo
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- CN101485822B CN101485822B CN200810246761XA CN200810246761A CN101485822B CN 101485822 B CN101485822 B CN 101485822B CN 200810246761X A CN200810246761X A CN 200810246761XA CN 200810246761 A CN200810246761 A CN 200810246761A CN 101485822 B CN101485822 B CN 101485822B
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Abstract
The invention discloses a traditional Chinese medicine with functions of eliminating phlegm and stopping cough, and a preparation method thereof. The medicine consists of the following raw materials in portion by weight: 2 to 10 portions of fructus momordicae, 1 to 7 portions of Szechuan-fritillary bulb, 1 to 5 portions of radix isatidis, 1 to 5 portions of scutellaria, 1 to 5 portions of ephedra, and 1 to 5 portions of licorice. The raw materials are prepared into granules, troche, oral liquid and syrups through the processing technique of extracting, condensing, refining and the like. The medicine has the efficacies of clearing away heat and toxic material, freeing lung and eliminating phlegm, and relieving cough and asthma, and is used for symptoms such as fever, cough, yellow sputum, bronchitis, whooping cough, pneumonia and the like caused by infantile phlegm heat in the lung.
Description
Technical field
The present invention relates to a kind of Chinese medicine and preparation method thereof, particularly relate to a kind of Chinese medicine and preparation method thereof, belong to the novel technique field with preventing phlegm from forming and stopping coughing effect.
Background technology
Cough is commonly encountered diseases, the frequently-occurring disease of Pediatric Clinic; Be that one of modal symptom of children's respiratory system disease, especially infant are often because of often cough of repeated infection, untimely treatment; Very easily cause lower respiratory infections such as bronchitis, pneumonia, influence the physical and mental health and life study of infant.
Children's's internal organs are tender and lovely, and the ability that resists on the one hand exopathogen is low, very easily ill, and on the other hand, because the function imperfection of each internal organs is very responsive to medicine, therefore, the ill back of child need be very prudent aspect use in the selection of medicine.
At present, though it is various to be used to treat the drug kinds of infantile cough, specific drug safely and effectively not; The clinical practice chemotherapy is comparatively general, and medicine is many to be main with analgesic, antitussive, antiinflammatory, but the clinical application side effect is big; Dangerous higher, the drug combination with antipyretic such as acetaminophen, aspirin phenacetin caffeine and antibiotics antibiotic medicine has more strengthened child's clinical application risk; Therefore, developing safely and effectively, child's cough suppressing medicine has good social benefit and economic benefit.
China's tradition Chinese medicine applicating history is long; The disease treatment advantage progressively obtains the approval of international community, but Chinese medicine is big at taking dose, the drug effect deficiency of aspect such as slowly, is having a strong impact on the development of Chinese medicine; And " thick, black, big " makes the application market of Chinese medicine receive very big restriction; Therefore, on the basis of utilization Chinese medicine treatment advantage, exploitation is imitated good modern Chinese medicine product of fine quality and is very important.
Summary of the invention
The object of the invention is to provide a kind of Chinese medicine with preventing phlegm from forming and stopping coughing effect, and this Chinese medicine has heat-clearing and toxic substances removing, dispersing lung-QI and dissipating phlegm, and the effect of relieving cough and asthma is used for children's's expectorant heat and violates that to defend caused heating, cough, expectorant in lung yellow, bronchitis, pertussis, pneumonia.
The present invention processes clinical acceptable drug dosage form, determined curative effect through processing technique such as extracting, concentrate, be refining.
Chinese medicine with preventing phlegm from forming and stopping coughing effect provided by the invention, form by the following weight proportion raw material:
Fructus Momordicae 2～10 weight portion Bulbus Fritillariae Cirrhosaes 1～7 weight portion
Radix Isatidis 1～5 weight portion Radix Scutellariae 1～5 weight portion
Herba Ephedrae 1～5 weight portion Radix Glycyrrhizae 1～5 weight portion
Chinese medicine with preventing phlegm from forming and stopping coughing effect provided by the invention is preferably by the following weight proportion raw material and forms:
Fructus Momordicae 4～8 weight portion Bulbus Fritillariae Cirrhosaes 2～6 weight portions
Radix Isatidis 2～4 weight portion Radix Scutellariaes 2～4 weight portions
Herba Ephedrae 2～4 weight portion Radix Glycyrrhizaes 2～4 weight portions
Chinese medicine with preventing phlegm from forming and stopping coughing effect provided by the invention, best for forming by following materials of weight proportions:
Fructus Momordicae 6 weight portion Bulbus Fritillariae Cirrhosaes 4 weight portions
Radix Isatidis 3 weight portion Radix Scutellariaes 3 weight portions
Herba Ephedrae 3 weight portion Radix Glycyrrhizaes 3 weight portions
The present invention adopts traditional handicraft to be processed into the various clinical pharmaceutical dosage form, like granule, tablet, oral liquid, syrup.
Preparation method of Chinese medicine with preventing phlegm from forming and stopping coughing effect provided by the invention may further comprise the steps:
(1) get Fructus Momordicae, Bulbus Fritillariae Cirrhosae, Radix Isatidis, Radix Scutellariae, Herba Ephedrae, Radix Glycyrrhizae, decocte with water, decocting liquid filters, and concentrated, precipitate with ethanol, concentrated gets concentrated solution;
(2) get above-mentioned concentrated solution, press conventional formulation technology and add proper auxiliary materials, be processed into corresponding dosage form.
Preparation method of Chinese medicine with preventing phlegm from forming and stopping coughing effect provided by the invention may further comprise the steps:
(1) gets Fructus Momordicae, Bulbus Fritillariae Cirrhosae, Radix Isatidis, Radix Scutellariae, Herba Ephedrae, Radix Glycyrrhizae, be ground into coarse powder, add 8～12 times of water gagings and decoct 1～3 time; Each 1～2 hour, decocting liquid filtered, and filtrating merges; Being evaporated to relative density is the clear paste of 1.10～1.15 (60 ℃), adds ethanol and makes that to contain alcohol amount be 65%, leaves standstill 24 hours; Filter, reclaim ethanol, concentrate, get concentrated solution;
(2) get above-mentioned concentrated solution, press conventional formulation technology and add proper auxiliary materials, process granule, tablet, oral liquid, syrup, promptly get the present invention.
Preparation method of Chinese medicine with preventing phlegm from forming and stopping coughing effect provided by the invention may further comprise the steps:
(1) gets Fructus Momordicae, Bulbus Fritillariae Cirrhosae, Radix Isatidis, Radix Scutellariae, Herba Ephedrae, Radix Glycyrrhizae, add 10 times of water gagings and decoct each 1.5 hours 2 times; Filtrating merges, and being concentrated into relative density is the clear paste of 1.10～1.15 (60 ℃), and adding ethanol is 65% to containing the alcohol amount; Left standstill 24 hours; Filter, reclaim ethanol, concentrate, get concentrated solution;
(2) get above-mentioned concentrated solution, press conventional formulation technology and add proper auxiliary materials, process granule, tablet, oral liquid, syrup, promptly get the present invention.
Adjuvant of the present invention is a common medicinal supplementary material,, sodium benzoate sweet like starch, dextrin, Icing Sugar, carboxymethyl starch sodium, little smart cellulose, magnesium stearate, Pulvis Talci, sucrose, Mel, A Siba etc.
Chinese medicine of the present invention is the basis with the theory of Chinese medical science, treating both the principal and secondary aspects of a disease, and the pharmacological effect experiment shows: have better antitussive, eliminate the phlegm and antiasthmatic effect.
Following experimental example and embodiment further prove but are not limited to the present invention.
The research of Test Example 1. antitussive effects
1.1 drawing, mice ammonia coughs experiment:
The ICR mice, male.Mice is placed in the 4L drying receptacle one by one; In exsiccator, feed 25% strong aqua ammonia 15s of atomizing with the speed of 4mL/min with ultrasound atomizer; Be transferred to rapidly under the funnel of back-off, listen cough latent period of mice and the cough number of times in the 2min at the funnel root with the stethoscope that has the bell joint.Select 60 of responsive mices in 2min incubation period, be divided into 6 groups at random, matched group, oral liquid 4mL/kg of the present invention, 8mL/kg, 16mL/kg group, CHUANBEI PIPA GAO 10g/kg group, mucosolvan 30mg/kg group.Continuous gastric infusion 3d, the administration volume is 20mL/kg, and matched group is given the normal saline with volume; Every day, dose was twice; Give 1h behind the full-time dose morning on the 4th, carry out ammonia spraying with method and draw and cough, observe the cough latent period and the interior cough number of times of 2min of mice.The result sees table 1.The result shows: oral liquid 8mL/kg of the present invention, but 16mL/kg significant prolongation control animal cough latent period, reduce cough number of times (p＜0.01), and show that cough has remarkable antitussive effect to oral liquid of the present invention to the ammonia inducing mouse.
The protective effect of table 1 pair ammonia inducing mouse cough
Compare with matched group:
*P＜0.01
*P＜0.05
1.2 drawing, the Cavia porcellus citric acid coughs experiment:
The DHP Cavia porcellus, male.Cavia porcellus is placed in the volumetrical glass bell jar of 3L, with the atomizing of 17.5% citric acid and spray in the glass bell jar, stop behind the spraying 1min with ultrasound atomizer; The cough latent period of observed and recorded Cavia porcellus; Choose incubation period less than 60 of the Cavia porcelluss of 2min, be divided into 6 groups: matched group, oral liquid 3mL/kg of the present invention, 6mL/kg, 12mL/kg group, CHUANBEI PIPA GAO 7g/kg group according to body weight and cough latent period collocation; Mucosolvan 20mg/kg group, 10 every group.Every day, dose gave for 2 times, and continuous 3d gives 1h behind the full-time dose morning on the 4th, draws as stated above and coughs experiment, observes the cough number of times in guinea pig cough's incubation period and the 2min, and the result sees table 2.The result shows: oral liquid 6mL/kg of the present invention; But 12mL/kg significant prolongation control animal cough latent period; Reduce cough number of times (p＜0.01), oral liquid 3mL/kg of the present invention also can reduce cough number of times (p＜0.05) demonstration oral liquid of the present invention and induce the guinea pig cough that remarkable antitussive effect is arranged to citric acid.
The protective effect that table 2 pair citric acid is induced the guinea pig cough
Compare with matched group:
*P＜0.01
*P＜0.05
2. phlegm-dispelling functions research
2.1 the phenol red drainage experiment of mouse lung
60 of ICR mices are divided into 6 groups at random, 10 every group.Grouping and administration are with 1.1.After giving full-time metering back 30min the morning on the 4th, the phenol red solution 0.5mL of every mouse peritoneal injection 0.25% also puts to death mice behind 30min, and back of the body position is fixing; Isolate trachea, insert plastic tube, wash with the sodium bicarbonate solution 0.4mL of the each absorption 5% of syringe of 1mL; Continuous 3 times, 3 times washing liquids are merged, add isopyknic dehydrated alcohol; The centrifugal 15min of 1000r/min gets supernatant, in the 546nm colorimetric; According to the phenol red standard curve for preparing in advance, read the phenol red concentration of eluate, calculate phenol red output.The result sees table 3.Oral liquid 8mL/kg of the present invention, 16mL/kg can significantly increase the phenol red eliminating amount of control animal (p＜0.01), show that phenol red drainage has remarkable antitussive effect to oral liquid of the present invention to mouse lung.
The phenol red influence of sending of table 3 pair mouse lung
Compare with matched group:
*P＜0.01
*P＜0.05
2.2 to Rana nigromaculata oral mucosa effect on ciliary movement
The healthy big frog is fixed on the frog board with frog nail back of the body position successively, separately goes up lower jaw, upper jaw mucosal surface is fully exposed, with the mucosa and the skin of the moistening exposure of normal saline.The cilium of oral mucous epithelia is towards esophagus direction swing, and as starting point, last angle of mandible line is as finish line with the mid point of the frog two eye socket leading edges.At the cork dust of an about 1mm of diameter of starting point placement, impel cork dust by the time of starting point with the stopwatch record by fibre swing to finish line, continuous 3 times, ask its meansigma methods, push away the time that cork dust moves same distance as ciliary movement before every frog administration respectively.Drip of the present invention oral liquid of 0.2ml towards upper jaw mucosal surface then through 0.45um filter membrane filterable 2%, 1%, 0.5%, 1% CHUANBEI PIPA GAO, matched group gives normal saline.Behind the 2min, the same method is used same cork dust, with the stopwatch record time of cork dust from same starting point to same finish line.Obtain meansigma methods 3 times, and with administration before relatively, the result sees table 4.The result shows oral liquid of the present invention under any dosage, can increase respiratory mucosa epithelium ciliary movement, makes expectorant be easy to expectoration (p＜0.01).
Table 4 couple Rana nigromaculata oral mucosa effect on ciliary movement n=10
3. Study on Antiasthmatic
3.1 to the volumetrical influence of guinea-pig isolated trachea
Choose body weight 300-400g healthy guinea pig, shoot dead, cut skin of neck and muscle open along median sagittal plane rapidly, take out complete trachea, place the Knebs-Henseleit nutritional solution with wooden stick.Wash trachea with nutritional solution, peel off the outer tissue that attaches.Trachea one end is pricked at capillary glass-tube tip, and the other end is pricked on the U-shaped pipe.The U-shaped pipe connects the syringe of inhaling nutritious liquid, and nutritional solution is injected in the trachea slowly, gets rid of endotracheal bubble, regulates capillary glass-tube liquid level to suitable height.Trachea is put into the bath pipe that fills nutritional solution, regulate trachea to suitable length (should keep certain tension force, again can not tractive too tight).Bath temperature remains on (38 ± 0.5) ℃, regulates the tongs on the air bag sebific duct, makes air bubble put into nutritional solution slowly, equably.After treating the constant 20min of capillary glass-tube liquid level; Slowly drip through filterable oral liquid liquid of the present invention of 0.45um filter membrane and fritillary-loquat liquid 100ul to bathing pipe; Make final concentration be respectively: oral liquid 0.1,0.2 of the present invention, 0.4mg/mL; Fritillary-loquat liquid 0.4mg/mL, matched group gives the equal-volume normal saline.Make medicine contact 5min with trachea, observe and write down the variation of liquid level in the capillary glass-tube, the result sees table 5.The result shows that oral liquid of the present invention under any experimental concentration, all can reduce the suction pipe liquid level, reduces nutritional solution volume (p＜0.01), has shown good diastole tracheal smooth muscle effect.
The volumetrical n=10 that influences of table 5 pair isolated tracheal
Compare with matched group:
*P＜0.01
*P＜0.05
3.2 acetylcholine and histamine mixed liquor are drawn the influence of the effect of breathing heavily to Cavia porcellus
Childhood, Cavia porcellus was 60, the male and female dual-purpose, and grouping and administration are with 1.2.Give 30min behind the whole day dosage morning on the 4th, Cavia porcellus is put in people's bell glass with 1.5kg/cm
2The pressure spray people 2% acetylcholine 0.4% mixed liquor 15s of histamine, observe the number of animals and the tic average latency of the overturning that has a convulsion in the record 6min also.The result sees table 6.The result shows that each dosage of oral liquid of the present invention all has tangible antiasthmatic effect (p＜0.05, p＜0.01).
Table 6 pair acetylcholine and histamine mixed liquor draw the antiasthmatic effect n=10 that breathes heavily to Cavia porcellus
In sum: oral liquid of the present invention draws ammonia to be coughed mice and citric acid and draws and cough Cavia porcellus significantly antitussive effect is all arranged; Can significantly strengthen the phenol red discharge of mouse lung and strengthen Rana nigromaculata oral mucosa ciliary movement; Acetylcholine and histamine mixed liquor drawn to breathe heavily to Cavia porcellus have remarkable antiasthmatic effect and the remarkable external GPTSM of diastole.Show that this medicine has good antitussive, eliminates the phlegm and antiasthmatic effect.
Following embodiment all can realize the effect of above-mentioned experimental example.
Embodiment 1 oral liquid
Fructus Momordicae 120g Bulbus Fritillariae Cirrhosae 80g Radix Isatidis 60g
Radix Scutellariae 60g Herba Ephedrae 60g Radix Glycyrrhizae 60g
Get Fructus Momordicae, Bulbus Fritillariae Cirrhosae, Radix Isatidis, Radix Scutellariae, Herba Ephedrae, Radix Glycyrrhizae, add 10 times of water gagings and decoct 2 times, each 1.5 hours, filtrating merged; Being concentrated into relative density is the clear paste of 1.10～1.15 (60 ℃), and adding ethanol is 65% to containing the alcohol amount, leaves standstill 24 hours; Filter, reclaim ethanol, be concentrated into an amount of; Add antiseptic and correctives, add water to 1000ml, stir, leave standstill, filter, fill, sterilization promptly gets.
Embodiment 2 granules
Fructus Momordicae 70g Bulbus Fritillariae Cirrhosae 110g Radix Isatidis 70g
Radix Scutellariae 50g Herba Ephedrae 70g Radix Glycyrrhizae 50g
Get Fructus Momordicae, Bulbus Fritillariae Cirrhosae, Radix Isatidis, Radix Scutellariae, Herba Ephedrae, Radix Glycyrrhizae, add 12 times of water gagings and decocted 2 hours, filtrating is concentrated into the clear paste that relative density is 1.10～1.15 (60 ℃), and adding ethanol is 65% to containing the alcohol amount; Left standstill 24 hours, and filtered, reclaim ethanol; Decompression recycling ethanol also is concentrated into the thick paste that relative density is 1.35 (50 ℃), adds sucrose and dextrin, mix homogeneously; Process granule, drying promptly gets.
Embodiment 3 tablets
Fructus Momordicae 150g Bulbus Fritillariae Cirrhosae 50g Radix Isatidis 50g
Radix Scutellariae 70g Herba Ephedrae 50g Radix Glycyrrhizae 70g
Get Fructus Momordicae, Bulbus Fritillariae Cirrhosae, Radix Isatidis, Radix Scutellariae, Herba Ephedrae, Radix Glycyrrhizae, add 8 times of water gagings and decoct 2 times, each 1 hour, filtrating was concentrated into the clear paste that relative density is 1.10～1.15 (60 ℃); Adding ethanol is 65% to containing the alcohol amount, leaves standstill 24 hours, filters, and reclaims ethanol; Decompression recycling ethanol also is concentrated into the thick paste that relative density is 1.35 (50 ℃), adds starch, dextrin, and mix homogeneously is processed granule; Drying, tabletting, coating promptly gets.
Embodiment 4 syrups
Fructus Momordicae 120g Bulbus Fritillariae Cirrhosae 50g Radix Isatidis 70g
Radix Scutellariae 70g Herba Ephedrae 70g Radix Glycyrrhizae 60g
Get Fructus Momordicae, Bulbus Fritillariae Cirrhosae, Radix Isatidis, Radix Scutellariae, Herba Ephedrae, Radix Glycyrrhizae, add 10 times of water gagings and decoct 2 times, each 1 hour, filtrating merged; Being concentrated into relative density is the clear paste of 1.10～1.15 (60 ℃), and adding ethanol is 65% to containing the alcohol amount, leaves standstill 24 hours; Filter, reclaim ethanol, be concentrated into an amount of; Get sucrose and add water boil and process syrup, with above-mentioned concentrated solution mixing, boil, put coldly, it is an amount of with essence to add sodium benzoate, adds water to ormal weight, stirs, leave standstill, and filtration, fill promptly gets.
Claims (7)
1. the Chinese medicine that has the preventing phlegm from forming and stopping coughing effect is characterized in that the active part of this Chinese medicine is made up of the following weight proportion raw material:
Fructus Momordicae 2～10 weight portion Bulbus Fritillariae Cirrhosaes 1～7 weight portion
Radix Isatidis 1～5 weight portion Radix Scutellariae 1～5 weight portion
Herba Ephedrae 1～5 weight portion Radix Glycyrrhizae 1～5 weight portion.
2. Chinese medicine according to claim 1 is characterized in that the active part of this Chinese medicine is made up of the following weight proportion raw material:
Fructus Momordicae 4～8 weight portion Bulbus Fritillariae Cirrhosaes 2～6 weight portions
Radix Isatidis 2～4 weight portion Radix Scutellariaes 2～4 weight portions
Herba Ephedrae 2～4 weight portion Radix Glycyrrhizaes 2～4 weight portions.
3. Chinese medicine according to claim 1 or claim 2 is characterized in that the active part of this Chinese medicine is made up of the following weight proportion raw material:
Fructus Momordicae 6 weight portion Bulbus Fritillariae Cirrhosaes 4 weight portions
Radix Isatidis 3 weight portion Radix Scutellariaes 3 weight portions
Herba Ephedrae 3 weight portion Radix Glycyrrhizaes 3 weight portions.
4. like the said Chinese medicine of claim 1-3, it is characterized in that: be processed into granule, tablet, oral liquid, syrup.
5. like the said preparation method of Chinese medicine of claim 1-3, may further comprise the steps:
(1) get Fructus Momordicae, Bulbus Fritillariae Cirrhosae, Radix Isatidis, Radix Scutellariae, Herba Ephedrae, Radix Glycyrrhizae, decocte with water, decocting liquid filters, and concentrated, precipitate with ethanol, concentrated gets concentrated solution;
(2) get above-mentioned concentrated solution, press conventional formulation technology and add proper auxiliary materials, be processed into corresponding dosage form.
6. method for preparing as claimed in claim 5 may further comprise the steps:
(1) gets Fructus Momordicae, Bulbus Fritillariae Cirrhosae, Radix Isatidis, Radix Scutellariae, Herba Ephedrae, Radix Glycyrrhizae, be ground into coarse powder, add 8～12 times of water gagings and decoct each 1～2 hour 1～3 time; Decocting liquid filters, and filtrating merges, and being evaporated to relative density is 1.10～1.15; 60 ℃ clear paste adds ethanol and makes that to contain alcohol amount be 65%, leaves standstill 24 hours; Filter, reclaim ethanol, concentrate, get concentrated solution;
(2) get above-mentioned concentrated solution, press conventional formulation technology and add proper auxiliary materials, be processed into corresponding dosage form.
7. like the said preparation method of Chinese medicine of claim 5, may further comprise the steps:
(1) gets Fructus Momordicae, Bulbus Fritillariae Cirrhosae, Radix Isatidis, Radix Scutellariae, Herba Ephedrae, Radix Glycyrrhizae, add 10 times of water gagings and decoct each 1.5 hours 2 times; Filtrating merges, and is concentrated into relative density and is 1.10～1.15,60 ℃ clear paste; Adding ethanol is 65% to containing the alcohol amount, leaves standstill 24 hours, filters; Reclaim ethanol, concentrate, get concentrated solution;
(2) get above-mentioned concentrated solution, press conventional formulation technology and add proper auxiliary materials, be processed into corresponding dosage form.
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| CN200810246761XA CN101485822B (en) | 2008-12-31 | 2008-12-31 | Chinese medicine with phlegm-resolving and cough-suppressing functions and preparation method thereof |
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| CN200810246761XA CN101485822B (en) | 2008-12-31 | 2008-12-31 | Chinese medicine with phlegm-resolving and cough-suppressing functions and preparation method thereof |
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102670950B (en) * | 2012-06-04 | 2013-09-18 | 黄芸 | Chinese medicinal oral liquid for treating cough and preparation method thereof |
| CN102688405B (en) * | 2012-06-14 | 2013-11-27 | 李良 | Bulbus fritillariae cirrhosae traditional Chinese medicine decoction for treating cough and preparation method |
| CN103461870B (en) * | 2013-07-22 | 2014-12-17 | 浦江县李字头梨膏糖厂 | Pear syrup candy and production method thereof |
| CN103505621A (en) * | 2013-09-27 | 2014-01-15 | 张洋 | Cough relieving and sputum reducing syrup and preparation method thereof |
| CN108567886A (en) * | 2017-03-10 | 2018-09-25 | 王洁梅 | A kind of Chinese and Western medicine synthesising preparation and preparation method thereof for treating cough |
| CN109924535B (en) * | 2019-03-04 | 2022-02-01 | 海口日岛香料有限公司 | Preparation method and application of momordica grosvenori flowers in fruit burning and spraying type hookah |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1562151A (en) * | 2004-03-30 | 2005-01-12 | 沈惠明 | Medicinal formulation for treating upper respiratory track infection and its design method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1562151A (en) * | 2004-03-30 | 2005-01-12 | 沈惠明 | Medicinal formulation for treating upper respiratory track infection and its design method |
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