CN101176742A - Pharmaceutical composition for curing cough - Google Patents
Pharmaceutical composition for curing cough Download PDFInfo
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- CN101176742A CN101176742A CNA2006101378802A CN200610137880A CN101176742A CN 101176742 A CN101176742 A CN 101176742A CN A2006101378802 A CNA2006101378802 A CN A2006101378802A CN 200610137880 A CN200610137880 A CN 200610137880A CN 101176742 A CN101176742 A CN 101176742A
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Abstract
The invention provides a drug combination for curing a cough, comprising a ginseng aqueous extract and a white-fungus aqueous extract. The invention is an oral liquid, a granule, a capsule, a dropping pill, a soft capsule, a tablet, a pill or a coating pill. The invention has the advantages of having strong antitussive effect and quick effect, being safe, acting on peripheral nerve endings, not influencing backbone and having no side effects.
Description
[technical field]
The present invention relates to drug world, relate to a kind of pharmaceutical composition that is used for the treatment of cough and preparation method thereof specifically.
[background technology]
Cough is a kind of protectiveness respiratory tract reflection; be that respiratory tract is upset (as inflammation; foreign body) after; send impulsion and import a kind of physiological reaction that the oblongata coughing centre causes into; can discharge respiratory secretions or foreign body, the cleaning of protection respiratory tract and unobstructed, therefore; cough generally is a kind of useful action, also sees healthy human body sometimes.In the ordinary course of things, to slightly and not frequent cough, as long as sputum or foreign body are discharged, just can natural remission, need not use antitussive.But, to those no expectorant and violent dry cough, or expectorant is arranged and too frequent play is coughed, not only increase patient's misery, influence is had a rest and sleep, increases physical demands, even promotes the development of disease to produce other complication, and this moment is more harm than good.So, should suitably use antitussive, with relieving cough.
The antitussive that the patient that coughs at present can select is of a great variety, according to the difference of drug mechanism, can be divided into two big classes to cough suppressing medicine:
The first kind is a central antitussive, as opium, codeine, morphine, dextromethorphan etc.This class medicine can optionally suppress the oblongata coughing centre and produce the medicine of cough suppressing effect, the effect of this class cough medicine is clear and definite, but has significant side effects, except slight inhibition respiratory center, gastrointestinal reaction, drowsiness, even more serious is to this class medicine dependence and tolerance constitute the infringement of spiritual aspect.
The second class medicine is a peripheral antitussive, as Benproperine phosphate, lysionotin etc.This class medicine is blocked the afferent impulse of coughre flex by suppressing lung-vagus reflex, plays antitussive action.Be usually used in acute bronchitis, bronchial asthma, pneumonia, the caused zest dry cough of pulmonary carcinoma, apasm of coughing etc.The defective of this class medicine is that the scope of application is narrower, can only be effective to the cough of some particular type.
In addition, also have some compound preparations to have maincenter inhibition and two kinds of effects of periphery inhibition concurrently, but because its prescription complexity, the mechanism of action is unclear.
But above-mentioned which kind of medicine no matter all can not and effect a radical cure from the cause of clear elaboration cough on the pathologic basis.And side effects of pharmaceutical drugs also can be brought new inconvenience to the patient.So, still need to provide a kind of better efficacy, the novel antitussive of particularly being free from side effects.
[summary of the invention]
[technical problem that will solve]
Pharmaceutical composition of the treatment cough that the purpose of this invention is to provide a kind of good effect, drug mechanism is clear and definite, composition is simple, has no side effect and preparation method thereof.
[technical scheme]
The present inventor is according to for over ten years peripheral nerve pathologic Study on Damage being found, because the neural sensor of a variety of causes damage, in the repair process after its damage, because the overexpression of neuron ion channel, various types of films receptor protein and the elecrtonegativity glycosylation of film surface protein and the transmembrane potential depolarization of inducing neural unit, cause sensor to be overexcited and produce and import discharge into, inspire radioactivity cough repeatedly.The cough major part is the reflex of outbreak repeatedly that produces owing to pharyngeal teleneuron is irritated.Therefore, in the teleneuron repair process, lower neural end and be subjected to the irritability of film tip film just can treat cough, and can promote neural recovery fully.
On the basis of this research, the invention provides a kind of pharmaceutical composition for the treatment of cough, this pharmaceutical composition contains Radix Panacis Quinquefolii water extract and Tremella water extract,
Wherein, described Radix Panacis Quinquefolii water extract makes by following method:
Get the Radix Panacis Quinquefolii of 1-3 weight portion, according to the ratio of 20-40ml water/1g Radix Panacis Quinquefolii, the 6-12h that under temperature 30-60 ℃, is soaked in water, Radix Panacis Quinquefolii separates with soak then, pulverizes to be the granule of diameter 0.05-1mm again; American ginseng granules, filters again at 100 ℃ of reflux, extract, 5-8h together with soak, and the filtrate that obtains is left standstill 8-12h under temperature 2-6 ℃, get supernatant, concentrates to reach the 20-30ml/1g Radix Panacis Quinquefolii;
Described Radix Panacis Quinquefolii water extract preferred manufacturing procedure is:
Get the Radix Panacis Quinquefolii of 1-2 weight portion, according to the ratio of 25-35ml water/1g Radix Panacis Quinquefolii, the 10-12h that under temperature 45-60 ℃, is soaked in water, Radix Panacis Quinquefolii separates with soak then, pulverizes to be the granule of diameter 0.05-0.5mm again; American ginseng granules, filters again at 100 ℃ of reflux, extract, 6-8h together with soak, and the filtrate that obtains is left standstill 10-12h under temperature 3-5 ℃, get supernatant, concentrates down for 100 ℃ in temperature to reach the 20-30ml/1g Radix Panacis Quinquefolii;
Wherein, described Tremella water extract makes by following method:
Get the Tremella of 1-3 weight portion, according to the ratio of 25-45ml water/1g Tremella, the 2-4h that under temperature 15-30 ℃, is soaked in water, after drop anhydrated, the water of equal volume placed in the autoclave when adding with immersion; At pressure 0.1-0.2Mpa, temperature 110-130 ℃ is extracted 3-6h down, filters, and so repeats to extract 1-3 time, and filtrate merges, and reconcentration reaches the 20-30ml/1g Tremella;
Described Tremella water extract preferred manufacturing procedure is:
Get the Tremella of 1-2 weight portion, according to the ratio of 30-40ml water/1g Tremella, the 3-4h that under temperature 25-30 ℃, is soaked in water, after drop anhydrated, the water of equal volume placed in the autoclave when adding with immersion; At pressure 0.1-0.2Mpa, temperature 120-130 ℃ is extracted 5-6h down, filters, and so repeats to extract 1-3 time, and filtrate merges, and concentrates down for 100 ℃ in temperature to reach the 20-30ml/1g Tremella.
Can also with the ethanol that adds 95-100% in the extraction concentrated solution of above-mentioned Radix Panacis Quinquefolii water extract and Tremella water extract to precipitation fully, filter precipitate, drying.
Pharmaceutical composition of the present invention can directly encapsulate the concentrated solution of Radix Panacis Quinquefolii water extract and Tremella water extract by routine sterilization back and be prepared into oral liquid when using, also can be to Mel that wherein adds the 0-2 weight portion or sucrose in order to regulate taste.
Also can be with being prepared into pharmaceutically other different dosage forms of acceptable with adjuvant pharmaceutically commonly used after Radix Panacis Quinquefolii water extract and the Tremella water extract drying, as granule, capsule, drop pill, soft capsule, tablet, pill or coated pill.Wherein Radix Panacis Quinquefolii and Tremella water extract (by dry product) are 1 with the weight proportion of adjuvant: 0-90.
Described adjuvant comprises diluent, as lactose, xylitol, mannitol, chitosan etc., according to the difference of selecting dosage form, can according to the existing conventional formulation method (as " drug formulation process ", the Zhang Jing chief editor, Chemical Industry Press, publish in August, 2005; " up-to-date materia medica and pharmaceutical preparation new technique application manual ", the Chen Bin chief editor, military medicine Science Press, publish in January, 2005) the different adjuvant of selection.
The disintegrating agent that can select such as carboxymethyl starch sodium CMS-Na, microcrystalline Cellulose etc.;
Binding agent for example is polyvinylpyrrolidone (PVP), sodium carboxymethyl cellulose (CMC-Na), low-substituted hydroxypropyl cellulose (L-HPC), Polyethylene Glycol (PEG) etc.;
Stabilizing agent for example be sorbic acid, p-Hydroxybenzoate, ethanol, citric acid like;
Inclusion agents for example is alpha-cyclodextrin (α-CD), beta-schardinger dextrin-(β-CD) and a N-LOK modified starch etc.;
Coating materials such as hydroxypropyl emthylcellulose (HPMC), Polyethylene Glycol (PEG), acrylic resin etc.;
Correctives such as Mel, sucrose etc.
The medical material Radix Panacis Quinquefolii and the Tremella that use in the pharmaceutical composition of the present invention can obtain by commodity purchasing.
Wherein said Radix Panacis Quinquefolii is the dry root of Araliaceae Radix Panacis Quinquefolii Panax quinguefolium L..Radix Panacis Quinquefolii has had the applicating history in more than 300 year clinically as health care medicine, and the traditional Chinese medical science thinks, it has the effect of lung benefiting the moon, clear asthenic fire, promoting the production of body fluid to quench thirst, is usually used in treating deficiency of the lung chronic cough, the tired disease such as tired of the dry pharynx of losing blood, thirsty, deficiency-heat.Modern study shows, it contains 16 kinds of trace element of needed by human and 17 kinds with upper amino acid and polysaccharide, polypeptide and multivitamin, has anticancer, resisting fatigue, anti-hypoxia, radioprotective, the anti-ageing multiple function of waiting for a long time, and coronary heart disease etc. is had better curative effect.
Tremella of the present invention is the sporophore of Tremellaceae plant Tremella Tremella fuciformis Berk..The traditional Chinese medical science thinks that it has the effect of the lung moistening and production of body fluid promoting, tonifying-Yin and nourishing-stomach, QI invigorating and blood regulating, is usually used in treating cough due to lung-heat, cough with blood-flecked phlegm, epistaxis, metrorrhagia, dry throat and mouth, gastrointestine dryness heat, palpitation and insomnia etc.It is found that in recent years Tremella has certain effect to raising liver detoxification function, enhancing body to the protection of atomic radiation.
In the pharmaceutical composition of the present invention, mainly contain Radix Panacis Quinquefolii polysaccharide in the Radix Panacis Quinquefolii water extract, mainly contain tremella polysaccharide in the Tremella water extract.Being used in combination of this two constituents can be reduced the negative charge characteristic on neuron film surface significantly, suppresses the irritability of tip sensor effectively, thereby reaches the purpose of treatment cough.When the water extract of Radix Panacis Quinquefolii directly prepares medicine without ethanol precipitation, wherein also contain the part ginsenoside, this composition does not influence the antitussive action of medicine, also has the effect of resisting fatigue, anti-hypoxia, raising immunity.
Because pharmaceutical composition of the present invention has the clear and definite mechanism of action and unique action pathway, so it has the effect of excellent treatment cough.
Pharmaceutical composition of the present invention is suitable for the treatment of various symptom coughs, especially acute and chronic dry cough, throat pain is had special curative effect, and senile cough (old-slow-bronchial tube) is had obvious therapeutic action.To the patient of bacterial infection is arranged, should cooperate antibacterials to treat together, the effect of itself and antimicrobial drug does not have and influences each other.
In addition, because pharmaceutical composition of the present invention can lower the irritability of film in the teleneuron repair process, and can promote neural recovery fully, so can also be in order to the medicine of preparation treatment teleneuron damage.
Amount of drug of the present invention is: for the adult, be calculated as 2-4g medical material/every day by raw material, the child reduces by half.
Usually onset in 40min behind the drug oral of the present invention.Taking medicine can obtain obvious effects and drug withdrawal in 3 days, and the long-term dry cough person takes continuously and can obtain obvious curative effects in 7 days.Old-slow-bronchial tube also there is clear and definite effect, but need takes for a long time.
[three] beneficial effect
Medicine of the present invention is owing to have the character of effecting a permanent cure, and therefore the cough to various symptoms all has therapeutical effect preferably, and because its effective ingredient is simply nontoxic, so this medicine avirulence and side effect.Simultaneously, process for preparing medicine simple and effective of the present invention is suitable for commercial production.
[description of drawings]
Fig. 1 is that medicine of the present invention is to the excitatoty depression effect figure of tracheal injury model peripheral nerve
Wherein tracheal wall is touched in "-" expression, and " 20s " represents oscillographic scanning speed, refers to that horizontal stroke length represents the time-histories in 20 seconds.
Fig. 2 is Coughing's change before and after the medicine of the present invention for patient takes
Wherein abscissa is writing time, and the 0min place is an administration time, and vertical coordinate is the cough number of times.
*Represent p＜0.1,
* *Represent p＜0.01 (comparing before taking medicine with after taking medicine).
[specific embodiment]
Can further be expressly understood the present invention by the specific embodiment of the invention given below, but these embodiment not limiting the scope of the invention.
The preparation of embodiment 1 medicine oral liquid of the present invention
(1) get Radix Panacis Quinquefolii 20g, add 600ml water, soak 10h under 30 ℃, pulverizing is the granule of diameter 0.1mm then;
(2) with american ginseng granules together with soak at 100 ℃ of reflux, extract, 5h, filter, solution leaves standstill 10h under 4 ℃ of temperature, get supernatant;
(3) get Tremella 30g, add 900ml water, soak 3h down for 25 ℃ in temperature, drop anhydrates behind branchs, and adding 900ml water places in the autoclave;
(4) at pressure 0.16Mpa, temperature is extracted 3h down for 120 ℃, gets filtrate, extracts merging filtrate altogether 2 times;
(5) filtrate that obtains of supernatant that step (2) is obtained and step (4) merges, and being concentrated into concentration 100 ℃ of backflows is the 20ml/2g raw material.
According to the preparation method of oral liquid, the gained concentrated solution is prepared into oral liquid.
The preparation of embodiment 2 medicament capsules of the present invention
(1) get Radix Panacis Quinquefolii 20g, add 500ml water, soak 10h under 45 ℃, pulverizing is the granule of diameter 1mm then;
(2) with american ginseng granules together with soak at 100 ℃ of reflux, extract, 7h, filter, solution leaves standstill 12h under 6 ℃ of temperature, get supernatant;
(3) get Tremella 20g, add 500ml water, soak 2h down for 30 ℃ in temperature, drop anhydrates behind branchs, and adding 500ml water places in the autoclave;
(4) at pressure 0.10Mpa, temperature is extracted 6h down for 110 ℃, gets filtrate, extracts merging filtrate altogether 1 time;
(5) filtrate that obtains of supernatant that step (2) is obtained and step (4) merges, and being concentrated into concentration 100 ℃ of backflows is the 20-30ml/2g raw material.
(6) in concentrated solution, add 95% ethanol to precipitation fully, filter precipitate, grind to form powdery after the drying.
According to the preparation method of tablet, the dry thing of gained effective ingredient is prepared into tablet together with adjuvants such as filler, disintegrating agent, excipient.
The preparation of embodiment 3 medicine capsules of the present invention
(1) get Radix Panacis Quinquefolii 20g, add 800ml water, soak 8h under 55 ℃, pulverizing is the granule of diameter 0.5mm then;
(2) with american ginseng granules together with soak at 100 ℃ of reflux, extract, 6h, filter, solution leaves standstill 12h under 4 ℃ of temperature, get supernatant, being concentrated into concentration is the 10ml/1g raw material, add dehydrated alcohol to precipitation fully, filter precipitate, grind to form powdery after the drying;
(3) get Tremella 20g, add 700ml water, soak 4h down for 20 ℃ in temperature, drop anhydrates behind branchs, and adding 700ml water places in the autoclave;
(4) at pressure 0.20Mpa, 125 ℃ of temperature are extracted 4h down, get filtrate, extract altogether 2 times, merging filtrate, it is the 10ml/1g raw material that 100 ℃ of backflows are concentrated into concentration, add dehydrated alcohol to precipitation fully, filter precipitate, grind to form powdery after the drying;
(5) powder that obtains of supernatant that step (2) is obtained and step (4) merges, mix homogeneously.
According to the preparation method of capsule, the dry thing of gained effective ingredient is prepared into capsule.
The evaluation of polysaccharide in embodiment 4 medicines of the present invention
Get each 0.5ml of aqueous solution that embodiment 1 gained oral liquid, embodiment 2 tablets grind rear solution and get embodiment 3 capsule contents, place test tube respectively; Add 2 of the alcoholic solution of α-Nai phenol of 5% in the test tube, shake up; The concentrated sulphuric acid that slowly adds 0.5ml with the tailing edge tube wall.The liquid interface has purplish red colour circle, is shown as the polysaccharide identification experiment positive.
Embodiment 5 mice cough-relievings experiment
Medicine and grouping, as shown in table 1, wherein the residue aqueous solution is Radix Panacis Quinquefolii and Tremella in the medicine of the present invention to be extracted the back residue mix the solution that the back continuation obtains with water extraction; The compound recipe codeine is oral is produced lot number 060306 by federalism pharmaceutical factory, Zhuhai; Fritillary and loquat cough mixture, Guangzhou Pangaoshou Pharmaceutical Co., Ltd produces, lot number D06064; Be the oral liquid of embodiment 1 gained for reagent 1,2 and 3.
Get body weight and be 152 of the kunming mices of 32.5 ± 2.5g, be divided into 7 groups at random by table 1, every group of male and female half and half.All the other 10 place volume respectively is 0.016m
3, have an air inlet and a gas outlet, can be airtight glass box in, inculcate to glass box with the air that contains 1.0% ammonia, the measurement animal produces under the ammonia effect brings out the incubation period of cough and the number of times of coughing in 2min, wherein represent Ke Sou incubation period animal to bringing out the sensitivity and the Drug resistance of cough medicine, on behalf of the air flue teleneuron, the cough number of times then be damaged back sensitivity increases.
To each group mouse stomach administration, in kind test the incubation period of its cough and the number of times of coughing according to table 1 behind the 30min in 2min, the result is as shown in table 1.As can be seen, the effect of medicine of the present invention and the effect of compound codeine are similar, yet cough-relieving intensity is better than compound codeine, and fritillary and loquat cough mixture does not have visible antitussive action at short notice.It can also be seen that the preparation method of medicine of the present invention is come out the extracts active ingredients of raw material Radix Panacis Quinquefolii and Tremella.
Table 1 mice cough-relieving experiment
| The medicine group | Number of animals | Drug dose | Bring out cough latent period (s) | Cough number of times (2min) |
| |
20 | 0.2 | 34.0±5.4 ** | 35.4±4.2 ** |
| The residue |
20 | 0.2 | 38.0±1.9 ** | 30.2±3.2 ** |
| The |
20 | 0.1 | 56.5±5.1 | 15.0±2.5 |
| Fritillary and loquat cough mixture | 22 | 0.1 | 24.6±1.8 ** | 43.2±2.7 ** |
| For |
20 | 0.1 | 56.3±4.5 ** | 8.7±1.8 ** |
| For |
20 | 0.2 | 48.5±3.6 ** | 13.3±3.3 ** |
| For |
20 | 0.4 | 60.8±5.3 ** | 8.6±1.8 ** |
*P＜0.01, medicine of the present invention and water and fritillary and loquat cough mixture are relatively
Get body weight and be the rat about 250g, the male and female dual-purpose, place an air inlet and a gas outlet, can be airtight vial in, make rat be directly exposed to that 10min induces tracheal injury in 7.5% the aqueous citric acid solution aerosol.Then, expose its superior laryngeal nerve, the ultimate fibre electrical activity of record superior laryngeal nerve, observing with nylon yarn stimulates tracheal wall to bring out the reflex activity of cough.After the oral liquid of the oral embodiment of the invention 1 gained, observe the change of identical irritant reaction.The results are shown in Figure 1.
As shown in Figure 1, as seen before taking medicine, the stimulation of trachea induces strong induced discharge reaction and back exoelectrical reaction, take medicine back 30 and 45min, and discharge obviously begins to be suppressed.Presentation of results, medicine of the present invention have the injured peripheral nervous end effect of being overexcited slightly of inhibition.Import on the animal model of discharge producing dystopy because of damage, prove that taking medicine of the present invention can suppress spontaneous and dystopy that bring out is imported discharge into effectively.This inhibition and physiological antitussive action to the sensitization of injured nerve tip impression has confidential relation.8 category-A nerve fibers are write down in this experiment altogether, all obtain similar result.
The 1-2 month in 1999, the worker that Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and consonance suffer from dry cough or chronic cough in the medical university is totally 101 people (wherein 23 people of child below 12 years old), takes observed result behind the pharmaceutical composition of the present invention.The results are shown in Table 2, as can be known, medicine of the present invention is 98% to treatment cough effective percentage.
Table 2
1Take and to eliminate cough in 6 days
2Take and to eliminate cough in 3 days
Embodiment 8 patients take medicine of the present invention front and back Coughing's change
Select 20 cough patients (age 8-45 year), the observation of participating in the experiment at random between every 8:00-16:00.Everyone takes placebo (Mel+starch is boiled) 30ml earlier, observes the average cough number of times that is total to before and after also record patient is taken medicine in the 2h.Take the oral liquid of the embodiment of the invention 1 gained at interval behind the 2h, observe and write down its average cough number of times in the common 2h before and after taking medicine.Wherein give placebo or pharmaceutical composition of the present invention in 0min.The results are shown in Figure 2, the result shows that placebo does not have tangible antitussive effect, and medicine of the present invention can suppress the attack times of coughing significantly.
Claims (10)
1. pharmaceutical composition for the treatment of cough is characterized in that it contains Radix Panacis Quinquefolii water extract and Tremella water extract,
Described Radix Panacis Quinquefolii water extract makes by following method: the Radix Panacis Quinquefolii of getting the 1-3 weight portion, ratio according to 20-40ml water/1g Radix Panacis Quinquefolii, the 6-12h that under temperature 30-60 ℃, is soaked in water, Radix Panacis Quinquefolii separates with soak then, pulverizes to be the granule of diameter 0.05-1mm again; American ginseng granules, filters again at 100 ℃ of reflux, extract, 5-8h together with soak, and the filtrate that obtains is left standstill 8-12h under temperature 2-6 ℃, get supernatant, concentrates to reach the 20-30ml/1g Radix Panacis Quinquefolii;
Described Tremella water extract makes by following method: get the Tremella of 1-3 weight portion, and according to the ratio of 25-45ml water/1g Tremella, the 2-4h that under temperature 15-30 ℃, is soaked in water, after drop anhydrated, the water of equal volume placed in the autoclave when adding with immersion; At pressure 0.1-0.2Mpa, temperature 110-130 ℃ is extracted 3-6h down, filters, and so repeats to extract 1-3 time, and filtrate merges, and reconcentration reaches the 20-30ml/1g Tremella.
2. pharmaceutical composition according to claim 1, it is characterized in that described Radix Panacis Quinquefolii water extract makes by following method: the Radix Panacis Quinquefolii of getting the 1-2 weight portion, ratio according to 25-35ml water/1g Radix Panacis Quinquefolii, 10-12h is soaked in water under temperature 45-60 ℃, Radix Panacis Quinquefolii separates with soak then, pulverizes to be the granule of diameter 0.05-0.5mm again; American ginseng granules, filters again at 100 ℃ of reflux, extract, 6-8h together with soak, and the filtrate that obtains is left standstill 10-12h under temperature 3-5 ℃, and supernatant refluxes to concentrate down for 100 ℃ in temperature and reaches the 20-30ml/1g Radix Panacis Quinquefolii.
3. pharmaceutical composition according to claim 1, it is characterized in that described Tremella water extract makes by following method: the Tremella of getting the 1-2 weight portion, ratio according to 30-40ml water/1g Tremella, soak 3-4h down at temperature 25-30 ℃, after drop anhydrates, the water of equal volume places in the autoclave when adding with immersion; At pressure 0.1-0.2Mpa, temperature 120-130 ℃ is extracted 5-6h down, filters, and so repeats to extract 1-3 time, and filtrate merges, and refluxing to concentrate down for 100 ℃ in temperature reaches the 20-30ml/1g Tremella.
4. pharmaceutical composition according to claim 1 is characterized in that described Radix Panacis Quinquefolii water extract and Tremella water extract are to extract toward it to add 95-100% ethanol in concentrated solution, until precipitation fully, filter and dried precipitate.
5. according to the described pharmaceutical composition of each claim of claim 1-4, its feature contains the adjuvant of pharmaceutically using always with the 0-90 weight portion in 1 weight portion Radix Panacis Quinquefolii and the Tremella water extract at it.
6. according to the described pharmaceutical composition of each claim of claim 1-4, it is characterized in that it is oral liquid, granule, capsule, drop pill, soft capsule, tablet, pill or coated pill.
7. according to the described pharmaceutical composition of each claim of claim 1-3, it is characterized in that it is an oral liquid.
8. the described preparation of drug combination method of claim 7, this method may further comprise the steps:
The preparation of Radix Panacis Quinquefolii water extract: get the Radix Panacis Quinquefolii of 1-3 weight portion, according to the ratio of 20-40ml water/1g Radix Panacis Quinquefolii, the 6-12h that under temperature 30-60 ℃, is soaked in water, Radix Panacis Quinquefolii separates with soak then, pulverizes to be the granule of diameter 0.05-1mm again; American ginseng granules, filters again at 100 ℃ of reflux, extract, 5-8h together with soak, and the filtrate that obtains is left standstill 8-12h under temperature 2-6 ℃, get supernatant, concentrates to reach the 20-30ml/1g Radix Panacis Quinquefolii;
The preparation of Tremella water extract: get the Tremella of 1-3 weight portion, according to the ratio of 25-45ml water/1g Tremella, the 2-4h that under temperature 15-30 ℃, is soaked in water, after drop anhydrated, the water of equal volume placed in the autoclave when adding with immersion; At pressure 0.1-0.2Mpa, temperature 110-130 ℃ is extracted 3-6h down, filters, and so repeats to extract 1-3 time, and filtrate merges, and reconcentration reaches the 20-30ml/1g Tremella;
The concentrated solution of Radix Panacis Quinquefolii and Tremella water extract is merged, and refluxing down for 100 ℃ in temperature is concentrated into the 20-30ml/2g medical material, adds the Mel and/or the sucrose of 0-2 weight portion in the concentrated solution, is prepared into oral liquid according to conventional method.
9. the application of the described pharmaceutical composition of claim 1 in preparation treatment acute and chronic dry cough, senile cough or throat pain medication.
10. the application of the described pharmaceutical composition of claim 1 in preparation treatment teleneuron damage medicine.
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| CN102793263A (en) * | 2012-08-27 | 2012-11-28 | 福建中烟工业有限责任公司 | Extraction method of tremella water extract concentrate and application of concentrate in tobaccos |
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| CN1459290A (en) * | 2002-05-22 | 2003-12-03 | 北京朗多科技发展有限责任公司 | Antitussive and its prepn. process |
| CN1292780C (en) * | 2002-06-11 | 2007-01-03 | 福建农大生物工程研究所851口服液厂 | Productive process for glossy ganoderma and cordyceps sinensis lung-reinforcing oral liquor |
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|---|---|---|---|---|
| CN102793263A (en) * | 2012-08-27 | 2012-11-28 | 福建中烟工业有限责任公司 | Extraction method of tremella water extract concentrate and application of concentrate in tobaccos |
| CN102793263B (en) * | 2012-08-27 | 2016-01-20 | 福建中烟工业有限责任公司 | The extracting method of white fungus water extracting liquid and the application in tobacco thereof |
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|---|---|
| CN101176742B (en) | 2012-07-18 |
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