CN111388617B - Traditional Chinese medicine composition for eliminating phlegm and relieving cough and preparation method thereof - Google Patents
Traditional Chinese medicine composition for eliminating phlegm and relieving cough and preparation method thereof Download PDFInfo
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- CN111388617B CN111388617B CN202010318000.1A CN202010318000A CN111388617B CN 111388617 B CN111388617 B CN 111388617B CN 202010318000 A CN202010318000 A CN 202010318000A CN 111388617 B CN111388617 B CN 111388617B
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- traditional chinese
- chinese medicine
- medicine composition
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a traditional Chinese medicine composition for reducing phlegm and relieving cough and a preparation method thereof, wherein the composition comprises the following raw materials: loquat leaves, white mulberry root-bark, Ardisia japonica, common fennel, vinegar rhizoma cyperi, scorched hawthorn fruit, inula flower, common coltsfoot flower and common hogfennel root, and the preparation method comprises the following steps: s1, processing Chinese medicinal materials, S2, breaking cell wall and pulverizing, S3, extracting, S4, extracting, S5, concentrating, S6, wet grinding and S7, and mixing with plasmids to obtain the granular Chinese medicinal composition. Compared with the prior art, the compound preparation has the advantages that through the compounding of the loquat leaves, the white mulberry root-bark, the ardisia japonica, the Japanese ardisia herb, the fennel, the vinegar-processed rhizoma cyperi, the scorched hawthorn fruit, the inula flower, the coltsfoot flower and the whiteflower hogfennel root, the compound preparation has better effects of relieving cough and asthma, moistening the lung and reducing phlegm, has better treatment effect on allergic asthma, improves the utilization rate of effective components in the preparation process, has quick drug effect, is easier to be absorbed by human bodies, does not add excipients and other auxiliary materials in the granulation process, and has high effectiveness and safety of products.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicine compositions, and particularly relates to a traditional Chinese medicine composition for reducing phlegm and relieving cough and a preparation method thereof.
Background
Cough is a common respiratory symptom, generally caused by inflammation, foreign body, physical or chemical irritation of the trachea, bronchial mucosa or pleura. Cough has a protective effect of removing respiratory tract foreign bodies and secretions. However, if the cough changes from acute to chronic without stop, the patient is often suffered from great pain, such as chest distress, pharynx itch, asthma and the like, and the persistent and acute cough not only affects rest, but also easily consumes physical strength, and can cause the destruction of the alveolar wall elastic tissue to induce emphysema. Cough may be accompanied by expectoration, so generally, cough should be accompanied by expectoration and phlegm reduction. At present, most western medicines are treated by antibiotics or western medicines containing anesthetic ingredients, so that cough can not be effectively eradicated, side effects are large, and drug resistance or dependence is easy to produce.
The traditional Chinese medicine has a long history and rich experience on the treatment of cough, and the traditional Chinese medicine considers that the cough is caused by external infection of six excesses and internal injury of viscera, and the cough is caused by sound and phlegm. It is caused by exogenous pathogenic factors attacking the lung or internal injury of zang-fu organs affecting the lung. The Su Wen pathogenesis Qi Yi Bao Ming Ji points out that cough means no phlegm but sound and lung qi injury but unclear; cough is silent with phlegm, and spleen is damp and moves with phlegm. Cough is a sound due to phlegm, and it is also due to lung qi hurting on the spleen and dampness. Cough is classified into exogenous cough and endogenous cough in traditional Chinese medicine, and although exogenous cough is easy to treat, if the exogenous cough is repeatedly suffered or after illness, the exogenous cough is converted into endogenous cough if the illness and the treatment are not proper. Cough due to internal injury can lead to lung, spleen and kidney deficiency and lung swelling, which is persistent and difficult to cure.
CN102028865A discloses a pharmaceutical composition for resolving phlegm and relieving cough, which is prepared by processing the following raw material medicines in parts by weight: 12-25 parts of radix rehmanniae, 5-15 parts of bulbus fritillariae cirrhosae, 10-24 parts of rhizoma anemarrhenae, 8-16 parts of radix scrophulariae, 5-15 parts of radix ophiopogonis, 10-24 parts of immature bitter orange and 5-12 parts of liquorice. The pharmaceutical composition is prepared from pure traditional Chinese medicines, does not contain chemical components, hormone, and toxic or side effect, and can relieve cough caused by pharyngeal diseases.
CN102430048A discloses a traditional Chinese medicine composition for treating cough and a preparation method thereof, the traditional Chinese medicine composition is prepared by fifteen traditional Chinese medicinal materials such as exocarpium citri rubrum, poria cocos, pericarpium trichosanthis, fresh rehmannia root, dried orange peel, platycodon grandiflorum, radix ophiopogonis, radix asteris, bitter apricot seed, rhizoma pinellinae praeparata, gypsum, stir-fried perilla seed, liquorice, flos farfarae and peppermint oil according to a certain weight proportion, and the traditional Chinese medicine composition is safe and free of toxic and side effects, has the effects of relieving cough and asthma, moistening lung and reducing phlegm, and can relieve symptoms of throat itching and pain, cough and asthma.
Compared with western medicines, the traditional Chinese medicine is safer, and has small toxic and side effects, but the traditional Chinese medicine composition for reducing phlegm and relieving cough at present has single traditional Chinese medicine syndrome type, slow effect, easy relapse of disease in the treatment process, persistent disease condition and poor effect.
Disclosure of Invention
In order to solve the technical problems, the invention provides a traditional Chinese medicine composition for reducing phlegm and relieving cough and a preparation method thereof.
In order to achieve the purpose, the invention adopts the following technical scheme:
a traditional Chinese medicine composition for eliminating phlegm and relieving cough comprises the following raw materials: loquat leaves, mulberry bark, stemona root, Japanese ardisia herb, common fennel fruit, vinegar nutgrass galingale rhizome, scorched hawthorn fruit, inula flower, common coltsfoot flower and common hogfennel root.
Preferably, the traditional Chinese medicine composition for reducing phlegm and relieving cough comprises the following raw materials in parts by weight: 3-8 parts of loquat leaves, 1-6 parts of white mulberry root-bark, 4-7 parts of radix stemonae, 5-8 parts of Japanese ardisia herb, 1-4 parts of fennel, 4-7 parts of vinegar rhizoma cyperi, 4-7 parts of scorched hawthorn fruit, 1-3 parts of inula flower, 3-5 parts of common coltsfoot flower and 3-6 parts of whiteflower hogfennel root.
The mass ratio of the cortex mori radicis, the fennel, the vinegar rhizoma cyperi and the radix peucedani is 2-4:2-3:5-6: 4-5.
The invention also provides a preparation method of the traditional Chinese medicine composition for reducing phlegm and relieving cough, which comprises the following steps:
s1, processing the Chinese herbal medicines: drying folium Eriobotryae, cortex Mori, radix Stemonae, herba Ardisiae Japonicae, fructus Foeniculi, rhizoma Cyperi processed with vinegar, Inulae flos, flos Farfarae and radix Peucedani;
s2, breaking the wall and preparing powder: breaking the walls of the Chinese medicinal materials processed in the step S1, and crushing to obtain wall-broken powder;
s3, extraction: extracting the wall-broken powder obtained in the step S2 to obtain an extract and dregs;
s4, extraction: adding magnetized water into the dregs obtained in the step S3, carrying out ultrasonic treatment, decocting with slow fire, and filtering to obtain filtrate and dregs;
s5, concentration: concentrating the filtrate obtained in the step S4 to obtain a concentrated solution;
s6, wet grinding: wet grinding the filter residue obtained in the step S4 and the scorched hawthorn fruit to obtain a wet material;
s7, mixed plasmid: and (4) uniformly mixing the wet material obtained in the step S6, the concentrated solution obtained in the step S5 and the extract obtained in the step S3, and carrying out plasmid formation to obtain the granular traditional Chinese medicine composition.
Preferably, the drying conditions in step S1 are: drying at 35-40 deg.C for 8-10 h.
Preferably, the particle size of the wall-broken powder in step S3 is 5-10 μm.
Preferably, the extraction in the step S3 is CO2 supercritical extraction, the extraction pressure is 10-15Mpa, the temperature is 35-40 ℃, the CO2 flow is 4-6 ml/g.min, and the extraction time is 60-80 min.
Preferably, the ultrasonic processing conditions in step S4 are: the ultrasonic frequency is 20-25kHz, the power is 500-550W, and the time is 10-20 min.
Preferably, the mass ratio of the dregs of a decoction to the water in the step S4 is 1: 3-5.
Preferably, the concentration in step S5 is 1/3-1/2 concentrated to the original filtrate.
Preferably, the wet grinding in step S6 is grinding at 3000rpm 2000-5 min.
Preferably, the plasmid in step S7 is: and (4) preparing the wet material obtained in the step (S6) into wet granules with the grain diameter of 0.2-1mm by using an extrusion type granulating machine with the pore diameter of 0.2-1mm, and then putting the wet granules into a hot air circulation drying machine, wherein the set temperature is less than or equal to 60 ℃, and drying until the moisture is less than or equal to 5% +/-1%.
The invention also provides application of the traditional Chinese medicine composition for reducing phlegm and relieving cough in preparation of capsules, tablets, granules and pills.
The invention has the beneficial effects that:
(1) the compound preparation has the advantages of good effects of relieving cough and asthma, moistening lung and reducing phlegm, quick response and difficult relapse through the compounding of the loquat leaves, the white mulberry root-bark, the stemona root, the Japanese ardisia herb, the fennel, the vinegar-processed cyperus tuber, the scorched hawthorn fruit, the inula flower, the common coltsfoot flower and the whiteflower hogfennel root.
(2) Meanwhile, in the research, the traditional Chinese medicine composition has a good treatment effect on allergic asthma when the mass ratio of the white mulberry root-bark, the fennel, the vinegar-processed rhizoma cyperi to the radix peucedani is 2-4:2-3:5-6: 4-5.
(3) The preparation method combines the preparation methods of processing, wall breaking, extracting and the like of the traditional Chinese medicines, improves the utilization rate of effective components in the traditional Chinese medicines, has quick drug effect, is easier to be absorbed by human bodies, does not add excipient and other auxiliary materials in the granulation process, and further improves the effectiveness and safety of the product.
Detailed Description
The embodiments of the present invention are described below in conjunction with specific embodiments, and before the embodiments of the present invention are further described, it is to be understood that the scope of the present invention is not limited to the specific embodiments described below; it is also to be understood that the terminology used in the examples is for the purpose of describing particular embodiments, and is not intended to limit the scope of the present invention.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.
The sources of the raw materials used in the present invention are not limited, and the raw materials used in the present invention are all those commonly available in the art unless otherwise specified.
Basic embodiment
A traditional Chinese medicine composition for eliminating phlegm and relieving cough comprises the following raw materials in parts by weight: 3-8 parts of loquat leaves, 1-6 parts of white mulberry root-bark, 4-7 parts of stemona root, 5-8 parts of Japanese ardisia herb, 1-4 parts of common fennel, 4-7 parts of vinegar rhizoma cyperi, 4-7 parts of scorched hawthorn fruit, 1-3 parts of inula flower, 3-5 parts of common coltsfoot flower and 3-6 parts of common hogfennel root;
the mass ratio of the cortex mori radicis, the fennel, the vinegar rhizoma cyperi and the radix peucedani is 2-4:2-3:5-6: 4-5.
The invention also provides a preparation method of the traditional Chinese medicine composition for reducing phlegm and relieving cough, which comprises the following steps:
s1, processing the Chinese herbal medicines: drying folium Eriobotryae, cortex Mori, radix Stemonae, herba Ardisiae Japonicae, fructus Foeniculi, rhizoma Cyperi processed with vinegar, Inulae flos, flos Farfarae and radix Peucedani at 35-40 deg.C for 8-10 hr;
s2, breaking the wall and preparing powder: breaking the walls of the Chinese medicinal materials processed in the step S1, and crushing to obtain wall-broken powder;
s3, extraction: performing CO treatment on the wall-broken powder with the particle size of 5-10 μm obtained in the step S22Supercritical extracting at 35-40 deg.C under 10-15Mpa with CO2The flow rate is 4-6 ml/g.min, and the extraction time is 60-80min to obtain extract and residue;
s4, extraction: according to the following steps: 3-5, adding magnetized water into the dregs obtained in the step S3, carrying out ultrasonic treatment for 10-20min under the conditions of the frequency of 20-25kHz and the power of 500-550W, decocting for 2-3h with slow fire, and filtering to obtain filtrate and filter residue;
s5, concentration: concentrating the filtrate obtained in the step S4 to 1/3-1/2 of the original filtrate to obtain a concentrated solution;
s6, wet grinding: grinding the filter residue obtained in the step S4 and the scorched hawthorn fruit for 4-5min at the rotating speed of 2000-3000rpm to obtain a wet material;
s7, mixed plasmid: and (3) uniformly mixing the wet material obtained in the step S6, the concentrated solution obtained in the step S5 and the extract obtained in the step S3, preparing wet granules with the grain diameter of 0.2-1mm by using an extrusion type granulator with the pore diameter of 0.2-1mm, and then putting the wet granules into a hot air circulation dryer, setting the temperature to be less than or equal to 60 ℃, and drying until the moisture is less than or equal to 5% +/-1%, so as to obtain the granular traditional Chinese medicine composition.
The components of the phlegm-resolving cough-relieving traditional Chinese medicine compositions of examples 1-10 are shown in tables 1 and 2.
TABLE 1 EXAMPLES 1-5 Components and amounts (in parts by weight) of phlegm-resolving and cough-relieving Chinese medicinal composition
TABLE 2 EXAMPLES 6-10 Components and amounts (in parts by weight) of phlegm-resolving and cough-relieving Chinese medicinal composition
| Components | Example 6 | Example 7 | Example 8 | Example 9 | Example 10 |
| Folium Eriobotryae | 6 | 6 | 6 | 6 | 6 |
| Cortex Mori | 2 | 4 | 3 | 3 | 7 |
| Stemona root | 5.5 | 5.5 | 5.5 | 5.5 | 5.5 |
| Japanese ardisia herb tea | 6 | 6 | 6 | 6 | 6 |
| Fennel fruit | 2 | 3 | 5 | 2.5 | 1 |
| Vinegar rhizoma Cyperi | 5 | 6 | 8 | 3 | 5.5 |
| Charred hawthorn | 5 | 5 | 5 | 5 | 5 |
| Inula flower | 2 | 2 | 2 | 2 | 2 |
| Common coltsfoot flower | 4 | 4 | 4 | 4 | 4 |
| Radix peucedani | 4 | 5 | 4.5 | 7 | 4.5 |
The preparation method of the traditional Chinese medicine composition comprises the following steps:
s1, processing the Chinese herbal medicines: drying folium Eriobotryae, cortex Mori, radix Stemonae, herba Ardisiae Japonicae, fructus Foeniculi, rhizoma Cyperi processed with vinegar, Inulae flos, flos Farfarae and radix Peucedani at 37 deg.C for 9 hr;
s2, breaking the wall and preparing powder: breaking the walls of the Chinese medicinal materials processed in the step S1, and crushing to obtain wall-broken powder;
s3, extraction: performing CO treatment on the wall-broken powder with the particle size of 8 mu m obtained in the step S22Supercritical extracting at 37 deg.C under 12Mpa with CO2Extracting at flow rate of 5 ml/g.min for 70min to obtain extract and residue;
s4, extraction: according to the following steps: 4, adding magnetized water into the dregs obtained in the step S3, carrying out ultrasonic treatment for 15min under the conditions of frequency 22kHz and power 530W, decocting for 2.5h with slow fire, and filtering to obtain filtrate and dregs;
s5, concentration: concentrating the filtrate obtained in the step S4 to 1/3-1/2 of the original filtrate to obtain a concentrated solution;
s6, wet grinding: grinding the filter residue obtained in the step S4 and the scorched hawthorn fruit for 4min at the rotating speed of 2000rpm to obtain a wet material;
s7, mixed plasmid: and (3) uniformly mixing the wet material obtained in the step S6, the concentrated solution obtained in the step S5 and the extract obtained in the step S3, preparing wet granules with the grain size of 0.5mm by using an extrusion type granulator with the pore diameter of 0.5mm, then putting the wet granules into a hot air circulation dryer, setting the temperature to be less than or equal to 60 ℃, and drying until the moisture is less than or equal to 5% +/-1% to obtain the granular traditional Chinese medicine composition.
Comparative example 1
The comparative example differs from example 5 in that: in step S3, the particle size of the wall-broken powder is 20 μm, the extraction pressure is 20Mpa, the temperature is 40 deg.C, and CO is added2The flow rate is 6 ml/g.min, and the extraction time is 90 min.
Comparative example 2
The comparative example differs from example 5 in that: in step S3, the particle size of the wall-broken powder is 5 μm, the extraction pressure is 9Mpa, the temperature is 42 deg.C, and CO is added2The flow rate is 3 ml/g.min, and the extraction time is 55 min.
Comparative example 3
The comparative example differs from example 5 in that: step S4 lacks sonication during the extraction process.
Comparative example 4
The comparative example differs from example 5 in that: step S4 extracts the frequency of ultrasonic treatment in the process of 30kHz, power 550W and time 25 min.
Experimental example I evaluation of antitussive Effect
The animal experiment was divided into 15 groups, examples 1-10, comparative examples 1-4 and blank control group, each group was prepared by randomly taking 10 18-22g NIH mice, half each of the males and females, administering the drugs by gavage at a dose of 1.08g/kg body weight 1 time a day for 3 consecutive days, 4 hours after the last administration, placing the mice in a bell jar with a volume of 4L, spraying 27% ammonia water uniformly at a constant pressure of 53.2KPa for 8 seconds, stimulating the mice to cough (with abdomen closed, head raised and mouth open as cough indicators), observing the cough latency of the mice and the number of cough within 5min, statistically processing the results by t-test, comparing the differences among the examples, comparative examples and blank control group, see Table 3.
Table 3 influence of the phlegm-resolving and cough-relieving traditional Chinese medicine composition on the cough induced by strong ammonia water in mice (n-10,
)
note: p < 0.05, P < 0.01 compared to the blank control.
As can be seen from table 3, compared with the blank control group, each of the groups of examples 1 to 10 can significantly prolong the cough latency of the mice caused by ammonia water and reduce the number of times of cough of the mice caused by ammonia water; the traditional Chinese medicine composition for reducing phlegm and relieving cough has the effects of moistening lung and relieving cough, and has a good lung-moistening and cough-relieving effect when the mass ratio of the white mulberry root-bark, the fennel, the vinegar-processed rhizoma cyperi to the radix peucedani is 2-4:2-3:5-6: 4-5. And the comparative examples 1 to 4 show that the change of the preparation method has different degrees of influence on the efficacy of the prepared traditional Chinese medicine composition for reducing phlegm and relieving cough.
Experimental example evaluation of the Effect of inhibiting phlegm formation
The animal experiment was divided into 15 groups, examples 1-10, comparative examples 1-4 and blank control group, 10 NIH mice were randomly selected from each group, each of the males and females was gavaged with a dose of 1.08g/kg body weight for 1 time per day for 3 consecutive days, 4 hours after the last administration, 0.25kg/L phenol red was intraperitoneally injected into each group of mice, 0.2mL was anesthetized after half an hour, the trachea segment was taken out and placed in 2mL of physiological saline, 0.1mL of 1mol/L NaOH solution was added, OD value was measured at 546nm using UV-240 UV and visible spectrophotometer, and the content of phenol red in the secretion of the trachea segment was calculated, and the results are shown in Table 4.
TABLE 4
Note: p < 0.05, P < 0.01 compared to the blank control.
As can be seen from Table 4, compared with the blank control group, each of the groups of examples 1-10 can increase the phenol red excretion amount of the respiratory tract of the mouse (P < 0.05), wherein the groups of examples 5-7 have more significant effects (P < 0.01), which indicates that the traditional Chinese medicine composition has the effect of reducing phlegm. And the comparative examples 1 to 4 show that the change of the preparation method has different degrees of influence on the drug effect of the prepared traditional Chinese medicine composition for reducing phlegm and relieving cough.
Experimental example three effects evaluation of allergic asthma
Modeling: male healthy guinea pigs (quality 250-280g) were adaptively raised for 3 days under the same conditions, and then were randomly divided into a blank control group, a model group, example 1-10 groups and comparative example 1-4 groups, each of which was 10 animals. The blank control group was injected with the same amount of physiological saline intraperitoneally, and the model group, examples 1-10 groups and comparative examples 1-4 groups were injected with 30 mg/kg-1 of cyclophosphamide (6 mg/ml-1, 0.5ml/100g injection) intraperitoneally the first day, 1ml suspension prepared from 2mg of egg protein and 100mg of aluminum hydroxide was injected intraperitoneally the second day, 1ml suspension prepared from 0.01mg of egg protein and 100mg of aluminum hydroxide was injected intraperitoneally the 21 days later, another injection was performed to induce sensitization of guinea pigs, and then the guinea pigs were placed in a 4L glass bell jar and atomized and inhaled with 1% egg protein solution for 30s to induce asthma.
The administration amount of 1.6g/kg was 1 time per day, and the model group and the blank control group were administered with the same amount of physiological saline for intragastric administration for 5 consecutive days, starting on day 1 after asthma induction in guinea pigs by 1% egg protein solution aerosol inhalation. On day 2 after asthma challenge by nebulizing 1% egg protein solution to guinea pigs, the guinea pigs were treated for cough.
The guinea pig was placed in a 4L glass bell jar and the aerosol inhalation concentration was 10－4After 30s of mols/L capsaicin solution, the nebulizer was turned off, and the number of coughing events in the guinea pigs within 2min, including the 30s, was counted and recorded.
After 1h of each gavage, 1% egg protein was selected to stimulate guinea pig asthma, and the incubation period of guinea pig asthma was recorded. The latent phase of asthma is the time required from the aspiration of egg protein after each episode to the development of asthma. The asthma is judged by taking symptoms such as accelerated respiratory rate, nodding respiratory asthma, nasal flaring, convulsion and the like, and after 6min of observation, the person without asthma is discarded and the record is carried out according to 360 s. The results are shown in Table 5.
TABLE 5
Table 3 effect of expectorant antitussive traditional Chinese medicine composition on guinea pig cough (n 10,
)
| group of | Latent period/s of induced asthma | Cough frequency/2 min |
| Blank control group | 108.28±11.55 | 17.41±9.07 |
| Model set | 45.49±8.6## | 54.89±11.30## |
| Example 1 | 68.65±8.17* | 40.65±10.11 |
| Example 2 | 67.08±7.39* | 41.64±9.99 |
| Example 3 | 68.97±9.01* | 41.34±9.67 |
| Example 4 | 70.01±11.11* | 40.87±9.04 |
| Example 5 | 118.35±20.51** | 15.82±10.29** |
| Example 6 | 110.23±21.27** | 16.11±12.12** |
| Example 7 | 112.67±22.34** | 16.33±15.41** |
| Example 8 | 65.12±7.89* | 42.34±10.87 |
| Example 9 | 66.34±7.95* | 41.01±9.22 |
| Example 10 | 66.50±8.29* | 40.54±10.16 |
| Comparative example 1 | 52.19±6.75 | 49.87±10.12 |
| Comparative example 2 | 53.76±7.98 | 49.76±9.82 |
| Comparative example 3 | 54.05±8.14 | 49.44±9.87 |
| Comparative example 4 | 54.98±8.67 | 48.67±10.72 |
Note: compared with the blank control group, # P < 0.05, # P < 0.01, compared with the model group, # P < 0.05, # P < 0.01.
As can be seen from Table 5, the phlegm-resolving and cough-relieving traditional Chinese medicine compositions of examples 5-7 of the present invention have decreased cough frequency, increased asthma-inducing latency, and statistically significant difference (P < 0.01), while the phlegm-resolving and cough-relieving traditional Chinese medicine compositions of examples 1-4 and examples 8-10 have increased asthma-inducing latency, and statistically significant difference ((P < 0.05), but less change in cough frequency, and statistically insignificant difference, compared to the model group, indicate that when the mass ratio of cortex Mori, fructus Foeniculi, Vinegar essence and radix Peucedani in the present invention is 2-4:2-3:5-6:4-5, the present invention has the effect of treating allergic asthma.
And the comparative examples 1 to 4 show that the change of the preparation method has great influence on the drug effect of the traditional Chinese medicine composition for reducing phlegm and relieving cough.
The present invention has been further described with reference to specific embodiments, which are only exemplary and do not limit the scope of the present invention. It will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention, and that such changes and modifications may be made without departing from the spirit and scope of the invention.
Claims (5)
1. The traditional Chinese medicine composition for reducing phlegm and relieving cough is characterized by being prepared from the following raw materials in parts by weight: 3-8 parts of loquat leaves, 1-6 parts of white mulberry root-bark, 4-7 parts of radix stemonae, 5-8 parts of Japanese ardisia herb, 1-4 parts of fennel, 4-7 parts of vinegar rhizoma cyperi, 4-7 parts of scorched hawthorn fruit, 1-3 parts of inula flower, 3-5 parts of common coltsfoot flower and 3-6 parts of whiteflower hogfennel root;
the preparation method of the traditional Chinese medicine composition for reducing phlegm and relieving cough comprises the following steps:
s1, processing the Chinese herbal medicines: drying folium Eriobotryae, cortex Mori, radix Stemonae, herba Ardisiae Japonicae, fructus Foeniculi, rhizoma Cyperi processed with vinegar, Inulae flos, flos Farfarae and radix Peucedani;
s2, breaking the wall and preparing powder: breaking the walls of the Chinese medicinal materials processed in the step S1, and crushing to obtain wall-broken powder;
s3, extraction: extracting the wall-broken powder obtained in the step S2 to obtain an extract and dregs;
s4, extraction: adding water into the dregs obtained in the step S3, carrying out ultrasonic treatment, decocting with slow fire, and filtering to obtain filtrate and filter residue;
s5, concentration: concentrating the filtrate obtained in the step S4 to obtain a concentrated solution;
s6, wet grinding: wet grinding the filter residue obtained in the step S4 and the scorched hawthorn fruit to obtain a wet material;
s7, mixing and granulating: uniformly mixing the wet material obtained in the step S6, the concentrated solution obtained in the step S5 and the extract obtained in the step S3, and granulating to obtain a granular traditional Chinese medicine composition;
the particle size of the wall-broken powder in the step S3 is 5-10 μm;
the extraction in step S3 is CO2Supercritical extracting at 35-40 deg.C under 10-15Mpa with CO2The flow rate is 4-6 ml/g.min, and the extraction time is 60-80 min;
the ultrasonic processing conditions in step S4 are: the ultrasonic frequency is 20-25kHz, the power is 500-550W, and the time is 10-20 min.
2. The traditional Chinese medicine composition for eliminating phlegm and relieving cough as claimed in claim 1, wherein the mass ratio of the white mulberry root-bark, the fennel, the vinegar-processed cyperus rotundus and the peucedanum root is 2-4:2-3:5-6: 4-5.
3. The traditional Chinese medicine composition for resolving phlegm and relieving cough as claimed in claim 1, wherein the drying conditions in step S1 are as follows: drying at 35-40 deg.C for 8-10 h.
4. The traditional Chinese medicine composition for resolving phlegm and stopping coughing as claimed in claim 1, wherein the wet grinding in step S6 is grinding at 2000-3000rpm for 4-5 min.
5. Use of the phlegm-resolving and cough-relieving traditional Chinese medicine composition of claim 1 or 2 in the preparation of capsules, tablets, granules and pills for resolving phlegm and cough.
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Address after: No. 188, Longbao Road, Shuangdong street, Luoding City, Yunfu City, Guangdong Province Applicant after: Yili Pharmaceutical (Luoding) Co., Ltd Address before: No. 188, Longbao Road, Shuangdong street, Luoding City, Yunfu City, Guangdong Province Applicant before: GUANGDONG YILI LUODING PHARMACEUTICAL Co.,Ltd. |
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