CN111388612A - Pharmaceutical composition for dispelling wind, moistening lung and relieving cough and preparation method thereof - Google Patents
Pharmaceutical composition for dispelling wind, moistening lung and relieving cough and preparation method thereof Download PDFInfo
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Abstract
The invention provides a pharmaceutical composition for dispelling wind, moistening lung and relieving cough and a preparation method thereof, belonging to the technical field of Chinese herbal medicines. The pharmaceutical composition is prepared from the following raw materials in parts by weight: 8-11 parts of honey ephedra, 7-11 parts of cicada slough, 14-16 parts of bitter apricot seed, 13-17 parts of bamboo shavings, 9-12 parts of thunberg fritillary bulb, 8-12 parts of rhizoma pinellinae praeparata, 12-16 parts of radix asteris, 14-18 parts of common coltsfoot flower and 6-13 parts of liquorice. The pharmaceutical composition is safe to use, does not cause damage to gastrointestinal tract, liver and kidney functions of patients, can treat the symptoms of the sequela cough of the patients with cold, bronchitis and pneumonia at the end of the course of the disease, and has extremely obvious curative effect on the cough after anti-infection treatment of inflammatory lesions of lung, bronchus and pharynx or after cold traditional Chinese medicine treatment.
Description
Technical Field
The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a pharmaceutical composition for dispelling wind, moistening lung and relieving cough and a preparation method thereof.
Background
Cough is a clinical symptom of the respiratory tract, and is caused by inflammation, foreign body, physical or chemical irritation to the trachea, the bronchial mucosa or the pleura. Cough has the protective effect of removing foreign matters and secretions in respiratory tract, but if the cough is not cured for a long time and is repeatedly attacked, the patient is greatly troubled, the cough is not comfortable if the cough is not cured for a long time, daily life and work are affected if the cough is severe, the sleep of the patient is seriously affected if the cough is at night, even a part of the patients cause bronchospasm, cough and asthma can not lie in bed, anxiety is induced, and the like. Most of the coughs are caused by respiratory virus or bacterial infection, and can be cured quickly after being treated correctly, but some coughs can disappear quickly after being treated by western medicines, but the coughs still exist, and are often paroxysmal dry coughs. After patients are treated by various antibiotics or mostly by heat-clearing cold-cool cold type cough drugs, cough symptoms are difficult to completely cure, antibiotic abuse is caused, the probability of fungal infection and flora imbalance is increased, and partial patients gradually turn into chronic cough.
With increasingly serious atmospheric pollution, the incidence of haze is continuously increased, the foul air has great harm to the respiratory system of a human body, and chronic cough with respiratory tract sterility is easily induced.
Chronic cough refers to a condition that the cough time exceeds 8 weeks, the chest X-ray examination result has no significant abnormality, and the cough is taken as the only symptom or the main symptom. The clinical manifestations of chronic cough are repeated cough, chronic cough, dry throat, itchy throat, no phlegm cough or little white phlegm. The chronic cough belongs to the category of chronic cough and chronic cough in the traditional Chinese medicine, and has the main pathogenesis that wind evil attacks the lung, and antibiotics or cold and cool medicines are used to cause internal obstruction of wind evil, lung failure in dispersing and descending and lung qi adverse rising. The disease is characterized by itching and dry throat due to wind pathogen entering lung, and frequent cough due to wind or cold touch inducing endogenous wind, lung descending and descending, adverse rising of lung qi and glottic impact, which cannot be self-stopped.
The existing Chinese and western medicine cough relieving products in the market are many and are useful for treating a plurality of medicines such as cold, bronchitis, pneumonia and the like, western medicines are usually used for anti-infection treatment aiming at lung, bronchus, pharyngeal inflammation and other pathological changes, Chinese patent medicines are mostly heat clearing, detoxifying, lung warming and other natures, and the medicines for treating the wind-evil attacking lung type cough are rare. Therefore, effective drugs for treating the wind-evil lung-entering cough symptoms need to be developed at present.
Disclosure of Invention
The invention aims to solve the technical problems and provides a pharmaceutical composition for dispelling wind, moistening lung and relieving cough and a preparation method thereof. The pharmaceutical composition provided by the invention has a remarkable effect on treatment of wind-evil attacking lung type cough, particularly has an anti-infection treatment effect on inflammatory lesions of lung, bronchus and pharynx or cough after cold traditional Chinese medicine treatment, is specially used for treating the symptoms of the sequela cough of patients in the end stage of the course of cold, bronchitis and pneumonia, has a remarkable effect, completely adopts a traditional Chinese medicine formula, is safe to use, and has small side effect and small dependence on patients.
One of the purposes of the invention is to provide a pharmaceutical composition for dispelling wind, moistening lung and relieving cough, which is prepared from the following raw materials in parts by weight:
8-11 parts of honey ephedra, 7-11 parts of cicada slough, 14-16 parts of bitter apricot seed, 13-17 parts of bamboo shavings, 9-12 parts of thunberg fritillary bulb, 8-12 parts of rhizoma pinellinae praeparata, 12-16 parts of radix asteris, 14-18 parts of common coltsfoot flower and 6-13 parts of liquorice.
For the wind evil entering lung type cough, the disease cannot be cured only by adopting anti-infection medicines for treating inflammatory lesions of lung, bronchus and pharynx. The applicant consults a large amount of research and finds that for treating the wind evil entering lung type cough, a treatment method for dispelling wind, moistening lung and relieving cough needs to be given. The traditional Chinese medicine treatment is based on the principle of disease treatment, pathogenic wind is always used as the first to expel wind, and pathogenic wind is removed to cure the disease for half; the basic theory of the traditional Chinese medicine considers that the lung is delicate, is favorable for moistening and is pernicious to dryness, and the lung moistening is beneficial to moistening and smoothing respiratory tracts and keeping local tension of alveoli, so that the respiratory function and the oxygenation function are smoothly completed; dispel wind and moisten lung, remove pathogenic qi and dry lung, and stop cough.
The traditional Chinese medicine composition provided by the invention completely adopts the compatibility of the traditional Chinese medicinal materials, and the reasonable selection and matching of the traditional Chinese medicinal materials can treat the symptoms of the sequela cough of patients with cold, bronchitis and pneumonia at the end of the course of the disease, and particularly has a better effect of improving the clinical symptoms of the cough after the anti-infection treatment of inflammatory lesions of the lung, the bronchus and the pharynx or the treatment of the cough by using cold traditional Chinese medicines. The medicine has high safety coefficient, small toxic and side effect and no dependence.
The compatibility principle of the pharmaceutical composition of the invention is as follows:
monarch:
honey Chinese ephedra cicada slough
The nature and taste of ephedra: pungent, slightly bitter and warm. It enters lung and bladder meridians. Stir-baked with honey can strengthen the action of moistening lung.
Cicada slough is sweet, salty and cool in nature. It enters lung and liver meridians.
The two herbs are used together to ventilate lung and dispel wind, attack lung wind-evil and cooperate to dispel wind, relieve cough and dyspnea.
Minister:
common aster flower
Aster tataricus is warm, pungent and sweet in nature and flavor, enters lung meridian, and has the effects of warming lung, depressing qi, relieving cough and reducing sputum.
Tussilago farfara is pungent, slightly sweet in flavor and warm in nature. It enters lung meridian. Has effects of moistening lung, descending qi, eliminating phlegm, and relieving cough.
The two drugs are used together to help the monarch drug to moisten lung and descend qi, and to check cough.
And (2) adjuvant:
processed pinellia tuber with bamboo shavings, bitter apricot kernel, thunberg fritillary bulb
Zhuru is sweet in nature and flavor and slightly cold in nature. Meridian tropism enters lung, stomach, heart and gallbladder meridians. Has the effects of clearing heat and eliminating phlegm.
Bitter apricot kernel is bitter in taste and slightly warm; has little toxicity. It enters lung and large intestine meridians. Has the effects of lowering qi, relieving cough and asthma.
Zhe Bei mu is bitter and cool in nature. It enters lung meridian and heart meridian. Has effects of eliminating phlegm and relieving cough.
Fa ban Xia is pungent and warm in nature and flavor. It enters spleen, stomach and lung meridians. Function, drying dampness and resolving phlegm.
The four medicines are used together to help the monarch medicine to resolve phlegm, descend qi and relieve cough.
The following steps are performed:
licorice root, radix Glycyrrhizae clears heat and resolves phlegm, and coordinates the effects of the other drugs in the recipe.
The pharmaceutical composition can achieve the maximum curative effect on the cough symptoms after the inflammatory lesions of the lung, the bronchus and the pharynx are treated in an anti-infection way or are treated by cold traditional Chinese medicines under the compatibility of the monarch, the minister, the assistant and the guide. Through a large number of researches, the applicant finds that when the compatibility is not carried out, the curative effect of the pharmaceutical composition is remarkably reduced when one component in the monarch drug is reduced, or the dosage formula of the ministerial drug is changed, or the compatibility principle of the monarch drug, the ministerial drug, the adjuvant drug and the guide is damaged, and the pharmaceutical composition plays a role in synergy and is beneficial to effectively treating the cough symptoms after the inflammatory lesions of the lung, the bronchus and the pharynx are treated by anti-infection treatment or cold traditional Chinese medicines.
As one of the preferable schemes, the pharmaceutical composition is prepared from the following raw materials in parts by weight:
10 parts of honey ephedra, 10 parts of cicada slough, 15 parts of bitter apricot seed, 15 parts of bamboo shavings, 10 parts of thunberg fritillary bulb, 10 parts of rhizoma pinellinae praeparata, 15 parts of aster, 15 parts of common coltsfoot flower and 10 parts of liquorice.
As a second preferred embodiment, the pharmaceutical composition is prepared from the following raw materials in parts by weight:
9 parts of honey ephedra, 8 parts of cicada slough, 15 parts of bitter apricot seed, 14 parts of bamboo shavings, 10 parts of thunberg fritillary bulb, 11 parts of rhizoma pinellinae praeparata, 14 parts of aster, 16 parts of common coltsfoot flower and 9 parts of liquorice.
As a third preferred scheme, the pharmaceutical composition is prepared from the following raw materials in parts by weight:
10 parts of honey ephedra, 9 parts of cicada slough, 15 parts of bitter apricot seed, 16 parts of bamboo shavings, 11 parts of thunberg fritillary bulb, 11 parts of rhizoma pinellinae praeparata, 15 parts of aster, 17 parts of common coltsfoot flower and 12 parts of liquorice.
Furthermore, the pharmaceutical composition is prepared into extractum, liquid medicine, tablets, pills or capsules.
The invention provides a traditional Chinese medicine formula, which can well treat the symptoms of the sequela cough of patients with cold, bronchitis and pneumonia at the end of the course of the disease, can well replace the traditional western medicine preparation, has large toxic and side effects on human bodies, is not recommended to be taken for a long time, and is easy to generate dependence. The traditional Chinese medicine preparation disclosed by the invention is completely prepared from traditional Chinese medicinal materials, and the traditional Chinese medicinal materials are reasonably selected and matched. Although the existing traditional Chinese medicine preparation can be used for anti-infection treatment aiming at inflammatory lesions of lung, bronchus and pharynx, and can also be used for treating early symptoms by adopting cold traditional Chinese medicines, the curative effect is not ideal for the high-frequency after-shave cough phenomenon of patients with cold, bronchitis and pneumonia in the end stage of the course of the disease, a special medicine is difficult to be effectively treated aiming at the after-shave cough, the patients generally need to take the medicine for a long time and relieve and recover by means of autoimmunity, but the time is usually too long, the body of the patients is injured, and the life quality is seriously affected.
The traditional Chinese medicine composition can well aim at the symptom, is particularly effective in anti-infection treatment of inflammatory lesions of lung, bronchus and pharynx or cough after cold traditional Chinese medicine treatment, relieves the pain of a patient with the residual cough, has obvious curative effect, can be used as a special medicine, and has high safety coefficient of medication, small toxic and side effects and no dependence.
The other purpose of the invention is to provide a preparation method of the pharmaceutical composition, which is to decoct the traditional Chinese medicinal materials to obtain liquid medicine, or to prepare the liquid medicine into extract after concentrating the liquid medicine, or to prepare the extract after drying and crushing the extract and adding auxiliary materials for granulation, or to prepare the powder by encapsulating the powder.
The pharmaceutical composition can be well used for preparing related medicines for dispelling wind, moistening lung and relieving cough, has a good curative effect on the sequela cough at the end stage of the disease, and has a good application prospect.
Compared with the prior art, the invention has the beneficial effects that:
the pharmaceutical composition provided by the invention adopts a therapy of dispelling wind, moistening lung and relieving cough, and can be specially and effectively used for treating wind evil entering lung type cough. The traditional Chinese medicine formula is completely adopted, the compatibility of medicines in the formulas is reasonable, the synergistic effect is generated, the medicine is safe to use, the damage to gastrointestinal tract, liver and kidney functions of patients is avoided, the pharmaceutical composition can be used for treating the residual cough symptoms of the patients with cold, bronchitis and pneumonia at the end of the course of the disease, and the curative effect of the cough after the anti-infection treatment of inflammatory lesions of lung, bronchus and pharynx or the cold traditional Chinese medicine treatment is extremely obvious.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more clearly understood, the present invention is described in detail below with reference to the following embodiments, and it should be noted that the following embodiments are only for explaining and illustrating the present invention and are not intended to limit the present invention. The invention is not limited to the embodiments described above, but rather, may be modified within the scope of the invention.
Example 1
A pharmaceutical composition for dispelling wind, moistening lung and relieving cough is prepared from the following raw materials in parts by weight: 8 parts of honey ephedra, 7 parts of cicada slough, 14 parts of bitter apricot seed, 13 parts of bamboo shavings, 9 parts of thunberg fritillary bulb, 8 parts of rhizoma pinellinae praeparata, 12 parts of aster, 14 parts of common coltsfoot flower and 6 parts of liquorice.
The medicinal composition is granulated and filled according to a conventional method, and is prepared into capsules, so that the capsule preparation which meets the dosage of a normal adult for 1 day is obtained and is used for treating the symptoms of the sequela cough of a patient in the late stage of the cold course.
Example 2
A pharmaceutical composition for dispelling wind, moistening lung and relieving cough is prepared from the following raw materials in parts by weight: 11 parts of honey ephedra, 11 parts of cicada slough, 16 parts of bitter apricot seed, 17 parts of bamboo shavings, 12 parts of thunberg fritillary bulb, 12 parts of rhizoma pinellinae praeparata, 16 parts of aster, 18 parts of common coltsfoot flower and 13 parts of liquorice.
The pharmaceutical composition is prepared into tablets according to a conventional method, and the tablets which are used for treating the symptoms of the sequela cough of patients in the late stage of the bronchitis course can be obtained according to the dosage of normal adults for 1 day.
Example 3
A pharmaceutical composition for dispelling wind, moistening lung and relieving cough is prepared from the following raw materials in parts by weight: 10 parts of honey ephedra, 10 parts of cicada slough, 15 parts of bitter apricot seed, 15 parts of bamboo shavings, 10 parts of thunberg fritillary bulb, 10 parts of rhizoma pinellinae praeparata, 15 parts of aster, 15 parts of common coltsfoot flower and 10 parts of liquorice.
The pharmaceutical composition is prepared into tablets according to a conventional method, and the tablets which are used for treating the symptoms of the sequela cough of patients in the late stage of the bronchitis course can be obtained according to the dosage of normal adults for 1 day.
Example 4
A pharmaceutical composition for dispelling wind, moistening lung and relieving cough is prepared from the following raw materials in parts by weight: 9 parts of honey ephedra, 8 parts of cicada slough, 15 parts of bitter apricot seed, 14 parts of bamboo shavings, 10 parts of thunberg fritillary bulb, 11 parts of rhizoma pinellinae praeparata, 14 parts of aster, 16 parts of common coltsfoot flower and 9 parts of liquorice.
The pharmaceutical composition is prepared into tablets according to a conventional method, and the tablets which are used for treating the symptoms of the sequela cough of patients in the late stage of the bronchitis course can be obtained according to the dosage of normal adults for 1 day.
Example 5
A pharmaceutical composition for dispelling wind, moistening lung and relieving cough is prepared from the following raw materials in parts by weight: 10 parts of honey ephedra, 9 parts of cicada slough, 15 parts of bitter apricot seed, 16 parts of bamboo shavings, 11 parts of thunberg fritillary bulb, 11 parts of rhizoma pinellinae praeparata, 15 parts of aster, 17 parts of common coltsfoot flower and 12 parts of liquorice.
The pharmaceutical composition is prepared into tablets according to a conventional method, and the tablets which are used for treating the symptoms of the sequela cough of patients in the late stage of the bronchitis course can be obtained according to the dosage of normal adults for 1 day.
Experimental example 1
The formulations obtained in examples 1-5 above were tested for animal toxicity and did not cause injury or death in mice. The method of using the agents of examples 1-5 for clinical treatment of patients is as follows:
(1) case data
100 patients, 50 men and 50 women, aged between 20-60 years, were treated.
Some of the cases are listed in table 1 below:
TABLE 1
(2) Method of treatment
The preparation is administered orally 2 times per day for 7 days.
(3) Criteria for therapeutic effect
The method has the following advantages: the cough symptom in the later period is relieved.
And (3) curing: effectively treat various symptoms, and improve clinical symptoms of cough caused by anti-infection treatment of inflammatory lesions of lung, bronchus and pharynx or treatment of cold traditional Chinese medicine.
(4) Results
After a patient uses the pharmaceutical composition for 7 days, 100 cases are effective, 91 cases are cured, the cure rate is 91%, and the effective rate is 100%.
Comparative example 1
7 parts of cicada slough and 14 parts of coltsfoot flower in example 1 are removed, and the rest remains unchanged, so that the treatment result is that 79 cases are effective, 69 cases are cured, the cure rate is 69%, and the effective rate is 79% after the patient uses the pharmaceutical composition for 5 days.
Comparative example 2
11 parts of honey ephedra and 13 parts of liquorice in the embodiment 2 are removed, and the rest remains unchanged, so that the treatment result is that after the medicine composition is used by a patient for 5 days, 68 cases are effective, 41 cases are cured, the cure rate is 41 percent, and the effective rate is 68 percent.
Comparative example 3
The 15 parts of aster in example 3 are removed, and the rest parts are kept unchanged, so that the treatment result is that after the patient uses the pharmaceutical composition for 5 days, 82 cases are effective, 68 cases are cured, the cure rate is 68%, and the effective rate is 82%.
Claims (7)
1. The pharmaceutical composition for dispelling wind, moistening lung and relieving cough is characterized by being prepared from the following raw materials in parts by weight:
8-11 parts of honey ephedra, 7-11 parts of cicada slough, 14-16 parts of bitter apricot seed, 13-17 parts of bamboo shavings, 9-12 parts of thunberg fritillary bulb, 8-12 parts of rhizoma pinellinae praeparata, 12-16 parts of radix asteris, 14-18 parts of common coltsfoot flower and 6-13 parts of liquorice.
2. The pharmaceutical composition for dispelling wind, moistening lung and relieving cough according to claim 1, which is prepared from the following raw materials in parts by weight:
10 parts of honey ephedra, 10 parts of cicada slough, 15 parts of bitter apricot seed, 15 parts of bamboo shavings, 10 parts of thunberg fritillary bulb, 10 parts of rhizoma pinellinae praeparata, 15 parts of aster, 15 parts of common coltsfoot flower and 10 parts of liquorice.
3. The pharmaceutical composition for dispelling wind, moistening lung and relieving cough according to claim 1, which is prepared from the following raw materials in parts by weight:
9 parts of honey ephedra, 8 parts of cicada slough, 15 parts of bitter apricot seed, 14 parts of bamboo shavings, 10 parts of thunberg fritillary bulb, 11 parts of rhizoma pinellinae praeparata, 14 parts of aster, 16 parts of common coltsfoot flower and 9 parts of liquorice.
4. The pharmaceutical composition for dispelling wind, moistening lung and relieving cough according to claim 1, which is prepared from the following raw materials in parts by weight:
10 parts of honey ephedra, 9 parts of cicada slough, 15 parts of bitter apricot seed, 16 parts of bamboo shavings, 11 parts of thunberg fritillary bulb, 11 parts of rhizoma pinellinae praeparata, 15 parts of aster, 17 parts of common coltsfoot flower and 12 parts of liquorice.
5. The pharmaceutical composition for dispelling wind, moistening lung and arresting cough according to claim 1, wherein the pharmaceutical composition is prepared into extract, liquid medicine, tablet, pill or capsule preparation.
6. The method for preparing a pharmaceutical composition for dispelling wind, moistening lung and arresting cough according to any one of claims 1 to 5, wherein the preparation is prepared by decocting each Chinese herbal medicine to obtain a liquid medicine, or concentrating the liquid medicine to prepare an extract, or drying and crushing the liquid medicine, adding auxiliary materials to granulate the dried and crushed liquid medicine, or filling the powder of the dried and crushed liquid medicine into capsules.
7. Use of the pharmaceutical composition of any one of claims 1-5 for the preparation of a medicament for treating a condition that is associated with dispelling wind, moistening lung for arresting cough.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111870658A (en) * | 2020-08-17 | 2020-11-03 | 中国人民解放军空军军医大学 | Traditional Chinese medicine formula for treating chronic cough variant asthma of elderly patients and preparation method |
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Application publication date: 20200710 |