CN1830482A - Chinese medicinal composition and application for treating child pneumonia for treating - Google Patents
Chinese medicinal composition and application for treating child pneumonia for treating Download PDFInfo
- Publication number
- CN1830482A CN1830482A CN 200510061798 CN200510061798A CN1830482A CN 1830482 A CN1830482 A CN 1830482A CN 200510061798 CN200510061798 CN 200510061798 CN 200510061798 A CN200510061798 A CN 200510061798A CN 1830482 A CN1830482 A CN 1830482A
- Authority
- CN
- China
- Prior art keywords
- parts
- rhizoma
- tablet
- flos lonicerae
- herba houttuyniae
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010035664 Pneumonia Diseases 0.000 title claims abstract description 18
- 239000000203 mixture Substances 0.000 title claims description 16
- 239000003814 drug Substances 0.000 claims abstract description 47
- 239000000463 material Substances 0.000 claims abstract description 9
- 241000605447 Anemarrhena Species 0.000 claims abstract description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 37
- 239000000284 extract Substances 0.000 claims description 21
- 241000628997 Flos Species 0.000 claims description 19
- UAJTZZNRJCKXJN-UHFFFAOYSA-M sodium;2-dodecoxy-2-oxoethanesulfonate Chemical compound [Na+].CCCCCCCCCCCCOC(=O)CS([O-])(=O)=O UAJTZZNRJCKXJN-UHFFFAOYSA-M 0.000 claims description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- 239000000654 additive Substances 0.000 claims description 13
- 239000002775 capsule Substances 0.000 claims description 13
- 238000002360 preparation method Methods 0.000 claims description 12
- 239000003826 tablet Substances 0.000 claims description 12
- 239000007788 liquid Substances 0.000 claims description 10
- 239000008187 granular material Substances 0.000 claims description 9
- 238000002156 mixing Methods 0.000 claims description 9
- 239000000843 powder Substances 0.000 claims description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 6
- 239000011248 coating agent Substances 0.000 claims description 6
- 238000000576 coating method Methods 0.000 claims description 6
- 239000002552 dosage form Substances 0.000 claims description 6
- 239000000706 filtrate Substances 0.000 claims description 6
- 238000005303 weighing Methods 0.000 claims description 6
- 238000000605 extraction Methods 0.000 claims description 5
- 239000002994 raw material Substances 0.000 claims description 5
- 229920002472 Starch Polymers 0.000 claims description 4
- 238000010992 reflux Methods 0.000 claims description 4
- 239000008107 starch Substances 0.000 claims description 4
- 235000019698 starch Nutrition 0.000 claims description 4
- 239000006188 syrup Substances 0.000 claims description 4
- 235000020357 syrup Nutrition 0.000 claims description 4
- 238000002481 ethanol extraction Methods 0.000 claims description 3
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 claims description 3
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 claims description 3
- GYCKQBWUSACYIF-UHFFFAOYSA-N o-hydroxybenzoic acid ethyl ester Natural products CCOC(=O)C1=CC=CC=C1O GYCKQBWUSACYIF-UHFFFAOYSA-N 0.000 claims description 3
- ARIWANIATODDMH-AWEZNQCLSA-N 1-lauroyl-sn-glycerol Chemical compound CCCCCCCCCCCC(=O)OC[C@@H](O)CO ARIWANIATODDMH-AWEZNQCLSA-N 0.000 claims description 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 2
- 229920001353 Dextrin Polymers 0.000 claims description 2
- 239000004375 Dextrin Substances 0.000 claims description 2
- 108010010803 Gelatin Proteins 0.000 claims description 2
- ARIWANIATODDMH-UHFFFAOYSA-N Lauric acid monoglyceride Natural products CCCCCCCCCCCC(=O)OCC(O)CO ARIWANIATODDMH-UHFFFAOYSA-N 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 2
- 239000004141 Sodium laurylsulphate Substances 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims description 2
- 239000002671 adjuvant Substances 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 235000019425 dextrin Nutrition 0.000 claims description 2
- 239000007919 dispersible tablet Substances 0.000 claims description 2
- 239000007938 effervescent tablet Substances 0.000 claims description 2
- 239000008273 gelatin Substances 0.000 claims description 2
- 229920000159 gelatin Polymers 0.000 claims description 2
- 235000019322 gelatine Nutrition 0.000 claims description 2
- 235000011852 gelatine desserts Nutrition 0.000 claims description 2
- 235000011187 glycerol Nutrition 0.000 claims description 2
- 239000000787 lecithin Substances 0.000 claims description 2
- 235000010445 lecithin Nutrition 0.000 claims description 2
- 229940067606 lecithin Drugs 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 2
- 238000005457 optimization Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 235000014101 wine Nutrition 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 3
- 240000002234 Allium sativum Species 0.000 abstract 1
- 241000205585 Aquilegia canadensis Species 0.000 abstract 1
- 241001038563 Pseudostellaria Species 0.000 abstract 1
- 244000223014 Syzygium aromaticum Species 0.000 abstract 1
- 235000016639 Syzygium aromaticum Nutrition 0.000 abstract 1
- 229930191283 anemarrhena Natural products 0.000 abstract 1
- 235000004611 garlic Nutrition 0.000 abstract 1
- 229940079593 drug Drugs 0.000 description 15
- 230000000694 effects Effects 0.000 description 7
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 210000004072 lung Anatomy 0.000 description 5
- 230000001681 protective effect Effects 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 4
- 241000699670 Mus sp. Species 0.000 description 4
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 description 4
- 239000003242 anti bacterial agent Substances 0.000 description 4
- 229940088710 antibiotic agent Drugs 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 241000699666 Mus <mouse, genus> Species 0.000 description 3
- 229940100050 virazole Drugs 0.000 description 3
- 206010059866 Drug resistance Diseases 0.000 description 2
- 206010062717 Increased upper airway secretion Diseases 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 241000193998 Streptococcus pneumoniae Species 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 230000000202 analgesic effect Effects 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 238000010255 intramuscular injection Methods 0.000 description 2
- 239000007927 intramuscular injection Substances 0.000 description 2
- 238000001990 intravenous administration Methods 0.000 description 2
- 231100000957 no side effect Toxicity 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 208000026435 phlegm Diseases 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 229940031000 streptococcus pneumoniae Drugs 0.000 description 2
- 241000712461 unidentified influenza virus Species 0.000 description 2
- 206010011469 Crying Diseases 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010035737 Pneumonia viral Diseases 0.000 description 1
- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- 206010039740 Screaming Diseases 0.000 description 1
- 241000238370 Sepia Species 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 230000002155 anti-virotic effect Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 235000019636 bitter flavor Nutrition 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000012869 ethanol precipitation Methods 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000003519 ventilatory effect Effects 0.000 description 1
- 208000009421 viral pneumonia Diseases 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
A Chinese medicine for treating infantile pneumonia is prepared from 8 Chinese-medicinal materials including pseudostellaria root, anemarrhena rhizome, garlic clove, honeysuckle flower, etc. Its preparing process is also disclosed.
Description
Technical field
The present invention relates to Chinese patent medicine, specifically a kind of is the Chinese medicine composition and the application of the treatment infantile pneumonia of main component with Chinese medicine.
Background technology
Pneumonia is one of common disease of children's, and the four seasons all can fall ill, with winter, spring be many.Pneumonia is the multiple disease in neonate, child, child's four seasons, because morbidity is anxious, process is fast, as misses treatment certain danger is arranged opportunity.Chinese children accounts for more than 60% of child outpatient based on the acute respiratory infection of pneumonia.The World Health Organization (WHO) points out that recently murderous child below five years old reached more than 4,300,000 in 1 year because of acute respiration organs such as pneumonia, is one of children's's three big dead causes of disease.
Treatment to pneumonia at present mainly controls inflammation, and how based on antibiotic medicine, improves the ventilatory function and the anti symptom treatment of lung.The particularly treatment of infantile pneumonia fundamentally be unable to do without antibiotics.The antibiotics use mostly acts on infant by the approach of intramuscular injection and intravenous drip.According to infant body constitution difference, treatment time is different in size, but needs above rehabilitation of a week smoothly the course of treatment, toward there being pneumonia medical history person then to need 2～4 weeks or longer time.Though the treatment based on antibiotics is effective, yet is difficult for radical cure, can show effect repeatedly with Changes in weather; The course of treatment is longer in addition, no matter particularly use intramuscular injection or intravenous drip, be difficult for bearing very much for children's, the sound of crying and screaming almost runs through whole therapeutic processes, thereby infantile pneumonia not only brings misery to infant, and to bring burden uneasy and economically to the head of a family also be very big.A large amount of in addition abuse of antibiotics medicines, infant are protracted course of disease repeatedly easily, brings very big misery to infant.
At the deficiencies in the prior art, the present invention proposes a kind ofly have good effect aspect the infantile pneumonia in treatment, the cycle is short, price is low, have no side effect and hold a little Chinese medicine composition.
Summary of the invention
Purpose of the present invention is exactly in order to address the above problem, providing a kind of is key component with Radix Pseudostellariae, the Rhizoma Anemarrhenae, Bulbus Allii, Rhizoma Phragmitis, SHILIANHUA, Herba Houttuyniae, Flos Lonicerae, Radix Platycodonis Chinese medicine, have that lung benefiting reduces phlegm, clear eliminating the pathogens from the lung heat, Yin-nourishing and body fluid promoting, anti-inflammatory analgetic effect, can suppress and remove streptococcus pneumoniae, improving and the adjustment immunity of organism, is the ideal Chinese medicine compositions of treatment infantile pneumonia obvious results.
The consumption of drug component of the present invention is groped to sum up to draw through the inventor in a large number, and each amounts of components all has curative effect preferably in following ranges, and medicine of the present invention contains
166～498 parts of 166～498 parts of Rhizoma Phragmitiss of 166～498 portions of Bulbus Alliis of 331～999 parts of Rhizoma Anemarrhenaes of Radix Pseudostellariae
110～330 parts of 110～330 parts of Radix Platycodoniss of 166～498 parts of Herba Houttuyniae of 166～498 parts of SHILIANHUA of Flos Lonicerae
Preferable range is:
248～498 parts of 248～498 parts of Rhizoma Phragmitiss of 248～498 portions of Bulbus Alliis of 498～998 parts of Rhizoma Anemarrhenaes of Radix Pseudostellariae
222～330 parts of 222～330 parts of Radix Platycodoniss of 248～498 parts of Herba Houttuyniae of 248～498 parts of SHILIANHUA of Flos Lonicerae
Optimum weight is:
450 parts of 450 parts of Rhizoma Phragmitiss of 450 portions of Bulbus Alliis of 666 parts of Rhizoma Anemarrhenaes of Radix Pseudostellariae
268 parts of 268 parts of Radix Platycodoniss of 450 parts of Herba Houttuyniae of 450 parts of SHILIANHUA of Flos Lonicerae
Technical problem to be solved by this invention is to realize by following technical scheme.Be characterized in the medicine that Radix Pseudostellariae, the Rhizoma Anemarrhenae, Bulbus Allii, Rhizoma Phragmitis, SHILIANHUA, Herba Houttuyniae, Flos Lonicerae, Radix Platycodonis etc. are made for raw material.The Chinese medicine composition of this treatment infantile pneumonia is characterized in that it is that component is formed or made active component and pharmaceutically acceptable additives are formed or make active component and pharmaceutically acceptable additives are formed by the alcohol extract of following main materials by the water extract of following main materials by following main materials.
Medicine of the present invention can adopt the Chinese medicine preparation conventional method to be prepared into any pharmaceutically useful conventional formulation.For example these crude drug pulverize mix homogeneously can be made powder takes after mixing it with water; Also can be with these medicines decocting together, the condensed water decocting liquid is made oral liquid then; But, preferably crude drug Bulbus Allii, Herba Houttuyniae, Flos Lonicerae are carried out special extraction such as ethanol extraction, but this can not limit protection scope of the present invention in order to make each crude drug of this medicine better bring into play drug effect.
Described pharmaceutically acceptable additives are following one or more: citric acid, sodium bicarbonate, ethyl hydroxybenzoate, tartaric acid, lecithin, sodium lauryl sulphate, glycerol, gelatin, Polyethylene Glycol, glycerol monolaurate (gelucire44/14), propylene glycol, dextrin, ethanol, dried starch.
Its dosage form can be a said dosage form on any pharmaceutics, as syrup, granule, capsule, tablet etc.; Described capsule can be common capsule, effervescent capsule or other various suitable capsules; Described tablet can be common tablet, effervescent tablet, dispersible tablet or other various suitable tablets, can be with suitable coating material coating also coating not; The preferred particulates agent.
The specific embodiment
Describe implementation of the present invention in detail below in conjunction with embodiment.
Embodiment 1: take by weighing each raw material by formula proportion, and pulverize that to grind into coarser powder standby.The Bulbus Allii, Herba Houttuyniae, the Flos Lonicerae that take by weighing described weight proportion carry out reflux, extract, twice with 70%～95% ethanol, merge extracted twice liquid, reclaim ethanol, and be dry under 45～55 ℃, gets dry extract 1; Residue after Radix Pseudostellariae, the Rhizoma Anemarrhenae, Rhizoma Phragmitis, SHILIANHUA, Radix Platycodonis and the Bulbus Allii of described weight proportion, Herba Houttuyniae, the Flos Lonicerae alcohol extraction is decocted with water twice, add water serves as easy not have powder at every turn, merge decocting liquid twice, filter to get filtrate 2, it is 1.15～1.35 extractum that concentrated filtrate becomes proportion, dry under 45～55 ℃, get dry extract 2; Merge dry extract 1 and 2, it is ground into powder, the active component of preparation cost invention medicine; With gained active component and pharmaceutically acceptable additives such as correctives, the abundant mixing of adjuvant, make any dosage form of pharmaceutics.As above-mentioned active component was pulverized 100 mesh sieves, with pharmaceutically acceptable additives such as mixings such as ethanol, starch, moistening, soften, take out when forming agglomerate, can be made into tablet after making granule and suitable additives mixing.
In the above-mentioned preparation method, when in the preferred steps (a) medicine being added ethanol extraction, adding amount of alcohol for the first time is 12 times, extracts 1 hour, and add amount of alcohol the second time is 10 times, extracts 1 hour.(b) during with the medicine extracting in water, add 10 times in water for the first time in, decocted 2 hours, add 8 times in water the second time, decocted 1.5 hours.
Embodiment 2:
The preparation method of syrup of the present invention:
Take by weighing each raw material: Radix Pseudostellariae 450 grams, the Rhizoma Anemarrhenae 450 grams, Bulbus Allii 400 grams, Rhizoma Phragmitis 400 grams, SHILIANHUA 250 grams, Herba Houttuyniae 250 grams, Flos Lonicerae 200 grams, Radix Platycodonis 200 grams.Bulbus Allii, Herba Houttuyniae, Flos Lonicerae carry out reflux, extract, merging extracted twice liquid with 70%～95% ethanol, reclaim ethanol, and be dry under 45～55 ℃, gets dry extract; The residue of the alcohol extraction of Radix Pseudostellariae, the Rhizoma Anemarrhenae, Rhizoma Phragmitis, SHILIANHUA, Radix Platycodonis and Bulbus Allii, Herba Houttuyniae, Flos Lonicerae decocting secondary each 1 hour, filters, merging filtrate is condensed into thick paste, adds the ethanol precipitation secondary, make and contain pure flow control and once reach 65%, for the second time reach 80%, filter, reclaim ethanol and be concentrated into about 700mL, with the dry extract mixing, stir moltenly while hot with sucrose, ethyl hydroxybenzoate alcohol liquid, add boiling water again, stir evenly promptly to full dose.
Embodiment 3:
The preparation method of dissolved granule of the present invention:
Take by weighing Radix Pseudostellariae 500 grams, the Rhizoma Anemarrhenae 500 grams, Bulbus Allii 400 grams, Rhizoma Phragmitis 400 grams, SHILIANHUA 300 grams, Herba Houttuyniae 300 grams, Flos Lonicerae 400 grams, Radix Platycodonis 200 grams.Bulbus Allii, Herba Houttuyniae, Flos Lonicerae carry out reflux, extract, merging extracted twice liquid with 70%～95% ethanol, reclaim ethanol, and be dry under 45～55 ℃.Residue decocting secondary with the alcohol extraction of Radix Pseudostellariae, the Rhizoma Anemarrhenae, Rhizoma Phragmitis, SHILIANHUA, Radix Platycodonis medicine coarser powder and Bulbus Allii, Herba Houttuyniae, Flos Lonicerae, 2 hours for the first time, 1 hour for the second time, filter, filtrate is condensed into thick paste, and drying was pulverized 100 mesh sieves, with dry extract 1 mixing, moistening, soften, take out when forming agglomerate, make dissolved granule.
In like manner, press the method for embodiment 3, add suitable additives and make capsule etc.
Preparation tool aromatic odor of the present invention, mildly bitter flavor acid, nontoxic, sepia syrup, faint yellow granule or tablet or capsule are arranged.
More than during each forms, weight is calculated with crude drug, in the present invention, if weight is unit with the gram, this composition can be made into 1000 doses of pharmaceutical preparatioies, described 1000 doses of fingers, 1000 doses in the final drug preparation of making, as make 1000 in 1000 of capsule preparations, 1000 in tablet, granule 1000g, oral liquid 1000 peace bottles, injection 1000 peace bottles, drop pill etc., also can make big packing as granule, as the 100-500 bag, specifically can be 100 bags, 150 bags, 200 bags, 250 bags, 500 bags, every bag can be used as dose 1 time.This weight of formulation can increase or reduce, but the raw medicinal herbs weight proportion constant rate between each composition.
The present invention be at distinguished veteran doctors of TCM on the basis of proved recipe, through a large amount of preparation technology test and the resulting pure Chinese medicinal preparation of clinical practice.Treating both the principal and secondary aspects of a disease of the present invention, evident in efficacy, have that lung benefiting reduces phlegm, a merit of clear eliminating the pathogens from the lung heat, Yin-nourishing and body fluid promoting, anti-inflammatory analgetic, can give full play to and suppress and kill streptococcus pneumoniae, improve and adjust immunity of organism, promote the effect of physical rehabilitation.
For a better understanding of the present invention, below further set forth the action effect of medicine of the present invention at clinical pharmacology, but not to the restriction of effect of the present invention.
The test of influenza virus induced mice pneumonia protective effect.
Get 120 of healthy mices, be divided into virazole positive drug matched group at random, the high and low dose group of trial drug of the present invention, list and model control group and normal control group, 20 every group, male and female half and half.Get 10 times of LD
50Amount (10TCLD
50) collunarium infecting mouse pulmonary, the normal control group sucks normal saline, 30ul/ only, infected back 2 hours, and gave every mice trial drug 20 of the present invention, 40mg/kg respectively, virazole 20mg/kg, im, model control group, normal control group then all give the 0.5ml normal saline, administration every day 3 times, successive administration 5 days.Begin to observe 15 days continuously from administration.Write down death toll and death time behind the mouse infection influenza virus every day, calculate dead protective rate as follows and prolong vital rates with the dead sum of every treated animal in 15 days:
Dead protective rate (%): (model group mortality rate-experimental group mortality rate);
Prolong vital rates (%): (experimental group on average life number of days-model group on average life number of days)/(model group is life number of days on average) * 100%.
Result of the test is as shown in table 2.Give the trial drug of the present invention of high and low dose after the mouse infection virus, all can reduce the animal dead rate, prolong average life number of days, along with drug dose increases, effect increases, and is better than the invention medicine of low dosage, and the model control group animal obviously became thin after 4 days, dyspnea, beginning is dead.Compare with model control group, the high and low dose of medicine of the present invention can significantly reduce animal dead rate (P＜0.05), and is better than virazole.
Table 2 trial drug is to the protective effect of mice viral pneumonia
| Group life rate | Dosage mg/kg | Mortality rate (%) | Dead protective rate (%) | Average life day (d) | Prolong and give birth to (%) |
| Matched group model group virazole group low dosage of the present invention high dose of the present invention | - - 20 20 40 | - 100 40 30 10 | - - 60 70 90 | 15 6.5±3.9 10.2±3.9 * 11.5±3.8 * 13.3±4.5 * | 88.9 76.7 106.5 |
Compare with model group
*P＜0.05
Above-mentioned result of the test is clear to show at medicine of the present invention certain antivirus action is arranged.
The present invention compares with similar Western medicine, it has reasonable recipe, drug resistance evident in efficacy, no and Drug resistance, has no side effect, treatment cycle is short, and low price the patient easily accept, taking convenience, mouthfeel be good, suitable characteristics such as takes for a long time, being easy to apply, is a kind of ideal Chinese medicine compositions of infantile pneumonia obvious results that is used for the treatment of.
Claims (7)
1, a kind of Chinese medicine composition for the treatment of infantile pneumonia is characterized in that it is that component is formed or made active component and pharmaceutically acceptable additives are formed or make active component and pharmaceutically acceptable additives are formed by the alcohol extract of following main materials by the water extract of following main materials by following main materials; It mainly is to be made by following raw materials in weight portion medicine:
166～498 parts of 166～498 parts of Rhizoma Phragmitiss of 166～498 portions of Bulbus Alliis of 331～999 parts of Rhizoma Anemarrhenaes of Radix Pseudostellariae
110～330 parts of 110～330 parts of Radix Platycodoniss of 166～498 parts of Herba Houttuyniae of 166～498 parts of SHILIANHUA of Flos Lonicerae
2, pharmaceutical composition according to claim 1 is characterized in that the formula optimization scope is:
248～498 parts of 248～498 parts of Rhizoma Phragmitiss of 248～498 portions of Bulbus Alliis of 498～998 parts of Rhizoma Anemarrhenaes of Radix Pseudostellariae
222～330 parts of 222～330 parts of Radix Platycodoniss of 248～498 parts of Herba Houttuyniae of 248～498 parts of SHILIANHUA of Flos Lonicerae
3, pharmaceutical composition according to claim 1 is characterized in that the formula optimization optimum weight is:
450 parts of 450 parts of Rhizoma Phragmitiss of 450 portions of Bulbus Alliis of 666 parts of Rhizoma Anemarrhenaes of Radix Pseudostellariae
268 parts of 268 parts of Radix Platycodoniss of 450 parts of Herba Houttuyniae of 450 parts of SHILIANHUA of Flos Lonicerae
4, according to the preparation method of claim 1,2 or 3 described Chinese medicine compositions, its feature comprises as follows
(a) take by weighing each raw material by formula proportion, and pulverize that to grind into coarser powder standby.
(b) Bulbus Allii, Herba Houttuyniae, the Flos Lonicerae that takes by weighing described weight proportion carries out reflux, extract, twice with 70%～95% ethanol, merges extracted twice liquid, reclaims ethanol, and be dry under 45～55 ℃, gets dry extract 1;
(c) residue after Radix Pseudostellariae, the Rhizoma Anemarrhenae, Rhizoma Phragmitis, SHILIANHUA, Radix Platycodonis and the Bulbus Allii of described weight proportion, Herba Houttuyniae, the Flos Lonicerae alcohol extraction is decocted with water twice, add water serves as easy not have powder at every turn, merge decocting liquid twice, filter to get filtrate 2, it is 1.15～1.35 extractum that concentrated filtrate becomes proportion, dry under 45～55 ℃, get dry extract 2;
(d) merge dry extract 1 and 2, it is ground into powder, the active component of preparation cost invention medicine;
(e) with gained active component and pharmaceutically acceptable additives such as correctives, the abundant mixing of adjuvant, make any dosage form of pharmaceutics.As above-mentioned active component was pulverized 100 mesh sieves, with pharmaceutically acceptable additives such as mixings such as ethanol, starch, moistening, soften, take out when forming agglomerate, can be made into tablet after making granule and suitable additives mixing.
5, when in the preferred steps (b) in the right 4 medicine being added ethanol extraction, adding amount of alcohol for the first time is 12 times, extracts 1 hour, and add amount of alcohol the second time is 10 times, extracts 1 hour.(c) during with the medicine extracting in water, add 10 times in water for the first time in, decocted 2 hours, add 8 times in water the second time, decocted 1.5 hours.
6, Chinese medicine composition according to claim 1 is characterized in that: described pharmaceutically acceptable additives are following one or more: citric acid, sodium bicarbonate, ethyl hydroxybenzoate, the right acid of wine, lecithin, sodium lauryl sulphate, glycerol, gelatin, Polyethylene Glycol, glycerol monolaurate (gelucire44/14), propylene glycol, dextrin, ethanol, dried starch.
7, Chinese medicine composition according to claim 1 is characterized in that: its dosage form can be a said dosage form on any pharmaceutics, as syrup, granule, capsule, tablet etc.; Described capsule can be common capsule, effervescent capsule or other various suitable capsules; Described tablet can be common tablet, effervescent tablet, dispersible tablet or other various suitable tablets, can be with suitable coating material coating also coating not; The preferred particulates agent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2005100617981A CN1830482B (en) | 2005-12-05 | 2005-12-05 | Chinese medicinal composition and application for treating child pneumonia for treating |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2005100617981A CN1830482B (en) | 2005-12-05 | 2005-12-05 | Chinese medicinal composition and application for treating child pneumonia for treating |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1830482A true CN1830482A (en) | 2006-09-13 |
| CN1830482B CN1830482B (en) | 2011-11-09 |
Family
ID=36993082
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2005100617981A Expired - Fee Related CN1830482B (en) | 2005-12-05 | 2005-12-05 | Chinese medicinal composition and application for treating child pneumonia for treating |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1830482B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102499977A (en) * | 2011-11-28 | 2012-06-20 | 马英 | Traditional Chinese medicine preparation for treating children bronchopneumonia |
| CN102613390A (en) * | 2012-03-26 | 2012-08-01 | 张奎昌 | Garlic straw extracts and preparation method and application thereof |
-
2005
- 2005-12-05 CN CN2005100617981A patent/CN1830482B/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102499977A (en) * | 2011-11-28 | 2012-06-20 | 马英 | Traditional Chinese medicine preparation for treating children bronchopneumonia |
| CN102499977B (en) * | 2011-11-28 | 2013-07-17 | 薛洁 | Traditional Chinese medicine preparation for treating children bronchopneumonia |
| CN102613390A (en) * | 2012-03-26 | 2012-08-01 | 张奎昌 | Garlic straw extracts and preparation method and application thereof |
| CN102613390B (en) * | 2012-03-26 | 2013-08-14 | 张奎昌 | Garlic straw extracts and preparation method and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1830482B (en) | 2011-11-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100344313C (en) | Chinese patent drug for treating infantile cold and repeated cold, and its prepn. method | |
| WO2021208335A1 (en) | Traditional chinese medicine composition capable of removing toxins, dispelling dampness, and disinhibiting throat, and application thereof | |
| CN105535439A (en) | Traditional Chinese medicinal composition for treating pharyngitis and preparation method thereof | |
| CN104435294A (en) | Traditional Chinese medicine for treating respiratory viral infection and pharmaceutical application thereof | |
| CN111249390A (en) | Forsythia-astragalus root compound preparation and preparation method and application thereof | |
| CN101683420B (en) | Applications of traditional Chinese medicine composition in preparation of medicament for treating acute pharyngitis | |
| WO2023125798A1 (en) | Traditional chinese medicine composition and preparation method and application thereof | |
| CN1935194A (en) | Chinese medicine composition for treating nephroma | |
| CN110193061B (en) | Preparation and application of traditional Chinese medicine granules for treating or preventing children influenza virus infection | |
| CN1830482B (en) | Chinese medicinal composition and application for treating child pneumonia for treating | |
| CN1814195B (en) | Chinese medicine composition for treating gynecopathy and its preparation method thereof | |
| CN1814176B (en) | Chinese medicinal composition for treating tuberculosis and its preparation method | |
| CN111358906B (en) | Traditional Chinese medicine composition suitable for exogenous diseases | |
| CN1899499A (en) | Chinese medicine composition for treating cold and its preparing method and use | |
| CN106075229A (en) | A kind of Chinese medicinal composition preparation treating anemopyretic cold | |
| CN1899574A (en) | Chinese medicine composition for preventing and controlling liver cancer and its use | |
| CN1814194A (en) | Chinese-western medicine composition for treating in fant's common cold and use thereof | |
| CN1814250B (en) | Chinese medicine composition for treating liver cirrhosis ascites and preparation method thereof | |
| CN1915401B (en) | Composition of Chinese traditional medicine for treating phthisis, and application | |
| CN104524187B (en) | A kind of Chinese medicine preparation for the treatment of laryngopharynx swelling and pain and preparation method thereof | |
| CN1291729C (en) | Antiviral Chinese medicine prepn of Hypericum perforatumand its prepn process | |
| CN105412407A (en) | Traditional Chinese medicine composition for preventing and curing flu as well as preparation method and application thereof | |
| CN101176765A (en) | Chinese medicine detoxication preparations and preparation method thereof | |
| WO2024125422A1 (en) | Pharmaceutical composition for preventing and treating coronavirus infections, preparation method therefor and use thereof | |
| CN101700323B (en) | Pharmaceutical composition for preventing and treating liver cancer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: NINGBO YUANZHI BIOTECHNOLOGY CO., LTD. Free format text: FORMER OWNER: YANG XIONGZHI Effective date: 20110927 Free format text: FORMER OWNER: YANG YIKAI |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20110927 Address after: 315100, room 10, building 68, Lane 402, Tai Mo Road, Ningbo, Zhejiang, Yinzhou District Applicant after: NINGBO YUANZHI BIOTECHNOLOGY Co.,Ltd. Address before: 315100 Zhejiang city of Ningbo province Yinzhou District County Road No. 888 east section of Zhejiang Pharmaceutical College Applicant before: Yang Xiongzhi Co-applicant before: Yang Yijie |
|
| CI01 | Publication of corrected invention patent application |
Correction item: The patent holder; the address of the patent holder Correct: Ningbo Yuanzhi Biotechnology Co., Ltd.|315100, room 10, building 68, Lane 402, Tai Mo Road, Ningbo, Zhejiang, Yinzhou District False: Yang Xiongzhi Yang Yikai|315100 Zhejiang city of Ningbo province Yinzhou District County Road No. 888 east section of Zhejiang Pharmaceutical College Number: 45 Volume: 27 |
|
| CI03 | Correction of invention patent |
Correction item: The patent holder; the address of the patent holder Correct: Ningbo Yuanzhi Biotechnology Co., Ltd.|315100, room 10, building 68, Lane 402, Tai Mo Road, Ningbo, Zhejiang, Yinzhou District False: Yang Xiongzhi Yang Yikai|315100 Zhejiang city of Ningbo province Yinzhou District County Road No. 888 east section of Zhejiang Pharmaceutical College Number: 45 Page: The title page Volume: 27 |
|
| ERR | Gazette correction |
Free format text: CORRECT: PATENTEE PATENTEE ADDRESS; FROM: YANG XIONGZHI YANG YIKAI;315100 ZHEJIANG PHARMACEUTICAL COLLEGE, NO.888, EAST SECTION, YINXIAN AVENUE, YINZHOU DISTRICT, NINGBO CITY, ZHEJIANG PROVINCE TO: NINGBO YUANZHI BIOTECHNOLOGY CO., LTD.;315100 ROOM 402, BUILDING 10, LANE 68, TAIYU ROAD, YINZHOU DISTRICT, NINGBO CITY, ZHEJIANG PROVINCE |
|
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20111109 Termination date: 20131205 |