CN101176765A - Chinese medicine detoxication preparations and preparation method thereof - Google Patents

Chinese medicine detoxication preparations and preparation method thereof Download PDF

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CN101176765A
CN101176765A CNA2007101657010A CN200710165701A CN101176765A CN 101176765 A CN101176765 A CN 101176765A CN A2007101657010 A CNA2007101657010 A CN A2007101657010A CN 200710165701 A CN200710165701 A CN 200710165701A CN 101176765 A CN101176765 A CN 101176765A
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chinese medicine
fructus
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张文武
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Abstract

The invention discloses a detoxification formulation of Chinese herbal medicine, which comprises the following raw material drugs (measured by weight): 10 to 30 of weeping forsythia, 7 to 15 of bupleurum, 4 to 12 of mint, 7 to 15 of great burdock achene, 7 to 15 of skunk bugbane; 10 to 30 of wild chrysanthemum flower, 10 to 30 of dyers woad leaf, 10 to 30 of franchet groundcherry fruit, 7 to 15 of wild buckwheat rhizome. As the application of preparing drug used for treating virus respiratory tract disease, experiments show that: the detoxification formulation of Chinese herbal medicine inhibits the influenza virus (A3), parainfluenza virus 1 type (HVJ), respiratory syncytial virus (RSV), and herpes simplex virus 1 and 2 type (HSV-1, HSV-2) to some extent; wherein, the inhibition effect upon parainfluenza virus is stronger and has the functions of anti-virus, bacteriostasis, anti-inflammation, pain killing, intensifying macrophage phagocytic function of body.

Description

A kind of Chinese medicine detoxicating preparation and preparation method thereof
Technical field
The present invention relates to a kind of Chinese medicine detoxicating preparation and preparation method thereof, especially the application of the medicine of upper respiratory tract infection such as the fear of cold that causes as preparation treatment influenza virus, heating, headache, weak, nasal obstruction, watery nasal discharge, pharyngalgia, dry cough and treatment acute tonsillitis, acute pharyngitis and oral ulcer belongs to the Chinese medicine preparation technical field.
Background technology
Viral respiratory disease is one group of acute self limiting commonly encountered diseases, can betide each age group, the adult has 1~3 time every year, the child can have respiratory tract disease every year 2~7 times, wherein about half is to be caused by virus, the cause of disease of child's lower respiratory illness forms the respiratory tract infection of Human virus's property and belongs to upper respiratory disease based on virus.The clinical manifestation of respiratory viral disease is variation, the lighter such as common cold and upper respiratory tract infection, and weight person can be bronchiolitis and pneumonia, even can be directed at death.Remove influenza virus and adenovirus vaccine at present, other respiratory virus infections still do not have effective bacterin preparation.This type of disease of treatment does not have specific drug at present, and doctor trained in Western medicine antiviral drugs side effect commonly used is bigger, may cause anemia as virazole, also may influence liver function.Use antibiotic therapy and can produce drug resistance and toxic and side effects and anaphylaxis.Therefore, seek the clinical application of the above-mentioned disease of a kind of effective treatment, become the problem that medical technical field is badly in need of solution.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine composition for the treatment of viral respiratory disease and oral ulcer and preparation method thereof.
Chinese medicine detoxicating preparation provided by the invention comprises that following raw medicaments in portion by weight makes: Fructus Forsythiae 10-30 part Radix Bupleuri 7-15 part Herba Menthae 4-12 part Fructus Arctii 7-15 part Rhizoma Cimicifugae 7-15 part Flos Chrysanthemi Indici 10-30 part Folium Isatidis 10-30 part Calyx Seu Fructus Physalis 10-30 part Rhizoma Fagopyri Dibotryis 7-15 part.
Described Chinese medicine detoxicating preparation comprises that following raw medicaments in portion by weight makes: 7 parts of 10 parts of Rhizoma Fagopyri Dibotryiss of 10 parts of Calyx Seu Fructus Physaliss of 10 portions of Folium Isatidiss of 7 parts of Flos Chrysanthemi Indicis of 10 parts of Rhizoma Cimicifugaes of 4 parts of Fructus Arctiis of 7 portions of Herba Menthaes of 10 parts of Radix Bupleuri of Fructus Forsythiae.
Described Chinese medicine detoxicating preparation comprises that following raw medicaments in portion by weight makes: 15 parts of 30 parts of Rhizoma Fagopyri Dibotryiss of 30 parts of Calyx Seu Fructus Physaliss of 30 portions of Folium Isatidiss of 15 parts of Flos Chrysanthemi Indicis of 15 parts of Rhizoma Cimicifugaes of 12 parts of Fructus Arctiis of 15 portions of Herba Menthaes of 20 parts of Radix Bupleuri of Fructus Forsythiae.
Described Chinese medicine detoxicating preparation comprises that following raw medicaments in portion by weight makes: 12.5 parts of 15 parts of Rhizoma Fagopyri Dibotryiss of 25 parts of Calyx Seu Fructus Physaliss of 25 portions of Folium Isatidiss of 15 parts of Flos Chrysanthemi Indicis of 15 parts of Rhizoma Cimicifugaes of 12.5 parts of Fructus Arctiis of 15 portions of Herba Menthaes of 25 parts of Radix Bupleuri of Fructus Forsythiae.
Described Chinese medicine detoxicating preparation comprises that following raw medicaments in portion by weight makes: 13 parts of 20 parts of Rhizoma Fagopyri Dibotryiss of 25 parts of Calyx Seu Fructus Physaliss of 22 portions of Folium Isatidiss of 15 parts of Flos Chrysanthemi Indicis of 12 parts of Rhizoma Cimicifugaes of 10 parts of Fructus Arctiis of 15 portions of Herba Menthaes of 10 parts of Radix Bupleuri of Fructus Forsythiae.
Described Chinese medicine detoxicating preparation is characterized in that this Chinese medicine detoxicating preparation made by following method:
1), raw materials weighing medicine in proportion, clean respectively;
2), the medical material after will cleaning adds 6-10 times of water gaging, steam distillation extracts volatile oil, carries oil time 5-8 hour, volatile oil device is in addition collected, decocting liquid filters, and is standby;
3), the medicine residue that will carry behind the oil adds 8-12 water doubly, reflux, extract, 2 times, each 1.5 hours;
4), with step 2) the water extract of gained decocting liquid and step 3) merges, and is evaporated to the clear paste of 60 ℃ of heat relative density 1.10-1.20 when surveying, adding 95% ethanol to determining alcohol is 65%, left standstill 24 hours, and got supernatant, filter, decompression filtrate recycling ethanol is to there not being the alcohol flavor, and is standby;
5), with step 2) volatile oil of gained and the filtration product of step 4) gained merge, formulation method is 1 part in said mixture routinely, adds people 0-2 part oral formulations adjuvant, makes concentrated pill, tablet, capsule, granule or oral liquid.
The elongation technology scheme of above-mentioned Chinese medicine detoxicating preparation comprises by following method to be made:
The fluid extract of relative density 1.20-1.40 when being evaporated to 60 ℃ of heat surveys behind the recovery ethanol again in the step 4).
Described Chinese medicine detoxicating preparation as the application of preparation treatment viral respiratory disease medicine is: as the preparation treatment because the fear of cold that influenza virus causes, heating, headache, weak, nasal obstruction, watery nasal discharge, pharyngalgia or dry cough medicinal application.
Described Chinese medicine detoxicating preparation as the application of preparation treatment viral respiratory disease medicine is: as preparation treatment oral ulcer or acute pharyngitis medicinal application.
Described Chinese medicine detoxicating preparation as the application of preparation treatment viral respiratory disease medicine is: as the medicinal application of preparation treatment acute tonsillitis.
Chinese medicine detoxicating preparation of the present invention shows through experimental study, to influenza virus A 3Type (A 3), Parainfluenza type 1 virus (HVJ), respiratory syncytial virus (RSV), (HSV-1 HSV-2) all demonstrates certain inhibitory action to herpes simplex virus types 1 and 2, and is wherein stronger to the parainfluenza virus inhibitory action; Pathological examination results shows that medicine of the present invention obviously suppresses mice interstitial lung inflammatory cell infiltration, improves the lung tissue pathological changes; High dose has significant protective effect to the death of influenza virus infecting mouse, and big or middle dosage obviously prolongs the mice time-to-live.Heavy dose causes dead mouse to staphylococcus aureus simultaneously certain protective role.Point out medicine of the present invention to have significantly antiviral, antibacterial anti-inflammatory, analgesia, the effect of enhancing body macrophage phagocytic function.See adnexa for details; The Chinese medicine detoxicating preparation cures mainly relevant Pharmacodynamic test of active extract data and documents and materials test unit with function: Beijing's pharmaceutical analysis institute
The specific embodiment
Example below in conjunction with the preparation of Chinese medicine detoxicating preparation capsule of the present invention, tablet, concentrated pill, granule, oral liquid illustrates the specific embodiment of the present invention and purposes.
Embodiment 1:
Fructus Forsythiae 250g, Radix Bupleuri 150g, Herba Menthae 125g, Fructus Arctii 150g, Rhizoma Cimicifugae 150g, Flos Chrysanthemi Indici 250g, Folium Isatidis 250g, Calyx Seu Fructus Physalis 150g, Rhizoma Fagopyri Dibotryis 125g
Preparation method:
1), weighing side's Chinese crude drug in proportion, clean respectively;
2), the medical material after will cleaning, add 8 times of water gagings, steam distillation extracts volatile oil, carries the 5 hours time of oil, volatile oil device is in addition collected, decocting liquid filters, and is standby;
3), will carry the decocting that medical material behind the oil adds 10 times and boil each 1.5 hours 2 times;
4), with step 2) the decocting liquid of gained decocting liquid and step 3) merges, and is evaporated to the clear paste of 60 ℃ of heat relative density 1.10 when surveying, adding 95% ethanol to determining alcohol is 65%, leaves standstill 24 hours, gets supernatant, decompression filtrate recycling ethanol is to there not being the alcohol flavor; Get sucrose 100g, add 400ml water heating for dissolving after, add people's supernatant, chlorhexidine acetate 0.2g stirs, regulating pH value with NaOH is 7.5, adds people's volatile oil and water and is settled to 1000ml, fill promptly gets oral liquid.
Embodiment 2:
15 parts of 30 parts of Rhizoma Fagopyri Dibotryiss of 30 parts of Calyx Seu Fructus Physaliss of 30 portions of Folium Isatidiss of 15 parts of Flos Chrysanthemi Indicis of 15 parts of Rhizoma Cimicifugaes of 12 parts of Fructus Arctiis of 15 portions of Herba Menthaes of 20 parts of Radix Bupleuri of Fructus Forsythiae
Preparation method:
1), weighing side's Chinese crude drug in proportion, clean respectively;
2), the medical material after will cleaning, add 7 times of water gagings, steam distillation extracts volatile oil, carries the 5 hours time of oil, volatile oil device is in addition collected, decocting liquid filters, and is standby;
3), the medical material that will carry behind the oil adds 8 times water, reflux, extract, 2 times, each 1.5 hours;
4), with step 2) the water extract of gained decocting liquid and step 3) merges, the clear paste of relative density 1.15 when being evaporated to 60 ℃ of heat surveys, adding 95% ethanol to determining alcohol is 65%, left standstill 24 hours, filter, decompression filtrate recycling ethanol is not to there being the alcohol flavor, and the fluid extract of relative density 1.25 is standby when being evaporated to 60 ℃ of hot surveys;
5), with step 2) volatile oil of gained and the extractum of step 4) gained routinely formulation method make concentrated pill.
Embodiment 3:
12.5 parts of 15 parts of Rhizoma Fagopyri Dibotryiss of 25 parts of Calyx Seu Fructus Physaliss of 25 portions of Folium Isatidiss of 15 parts of Flos Chrysanthemi Indicis of 15 parts of Rhizoma Cimicifugaes of 12.5 parts of Fructus Arctiis of 15 portions of Herba Menthaes of 25 parts of Radix Bupleuri of Fructus Forsythiae
Preparation method:
1), weighing side's Chinese crude drug in proportion, clean respectively;
2), the medical material after will cleaning, add 9 times of water gagings, steam distillation extracts volatile oil, carries the 6 hours time of oil, volatile oil device is in addition collected, decocting liquid filters, and is standby;
3), the medical material that will carry behind the oil adds 9 times water, reflux, extract, 2 times, each 1.5 hours;
4), with step 2) the water extract of gained decocting liquid and step 3) merges, the clear paste of relative density 1.15 when being evaporated to 60 ℃ of heat surveys, adding 95% ethanol to determining alcohol is 65%, left standstill 24 hours, filter, decompression filtrate recycling ethanol is not to there being the alcohol flavor, and the fluid extract of relative density 1.30 is standby when being evaporated to 60 ℃ of hot surveys;
5), in step 2) volatile oil of gained and the extractum of step 4) gained is 1 part, the tabletting adjuvant that adds about 0.2 part of people formulation method is routinely made tablet.
Embodiment 4:
13 parts of 20 parts of Rhizoma Fagopyri Dibotryiss of 25 parts of Calyx Seu Fructus Physaliss of 22 portions of Folium Isatidiss of 15 parts of Flos Chrysanthemi Indicis of 12 parts of Rhizoma Cimicifugaes of 10 parts of Fructus Arctiis of 15 portions of Herba Menthaes of 10 parts of Radix Bupleuri of Fructus Forsythiae
Preparation method:
1), weighing side's Chinese crude drug in proportion, clean respectively;
2), the medical material after will cleaning, add 10 times of water gagings, steam distillation extracts volatile oil, carries the 7 hours time of oil, volatile oil device is in addition collected, decocting liquid filters, and is standby;
3), the medical material that will carry behind the oil adds 10 times water, reflux, extract, 2 times, each 1.5 hours;
4), with step 2) the water extract of gained decocting liquid and step 3) merges, the clear paste of relative density 1.20 when being evaporated to 60 ℃ of heat surveys, adding 95% ethanol to determining alcohol is 65%, left standstill 24 hours, filter, decompression filtrate recycling ethanol is not to there being the alcohol flavor, and the fluid extract of relative density 1.35 is standby when being evaporated to 60 ℃ of hot surveys;
5), in step 2) volatile oil of gained and the extractum of step 4) gained is 1 part, add about 0.1 part filler routinely formulation method make capsule.
Embodiment 5:
20 parts of 20 parts of Rhizoma Fagopyri Dibotryiss of 25 parts of Calyx Seu Fructus Physaliss of 22 portions of Folium Isatidiss of 15 parts of Flos Chrysanthemi Indicis of 12 parts of Rhizoma Cimicifugaes of 8 parts of Fructus Arctiis of 10 portions of Herba Menthaes of 15 parts of Radix Bupleuri of Fructus Forsythiae
Preparation method:
1), weighing side's Chinese crude drug in proportion, clean respectively;
2), the medical material after will cleaning, add 10 times of water gagings, steam distillation extracts volatile oil, carries the 7 hours time of oil, volatile oil device is in addition collected, decocting liquid filters, and is standby;
3), the medical material that will carry behind the oil adds 10 times water, reflux, extract, 2 times, each 1.5 hours;
4), with step 2) the water extract of gained decocting liquid and step 3) merges, the clear paste of relative density 1.20 when being evaporated to 60 ℃ of heat surveys, adding 95% ethanol to determining alcohol is 65%, left standstill 24 hours, filter, decompression filtrate recycling ethanol is not to there being the alcohol flavor, and the fluid extract of relative density 1.35 is standby when being evaporated to 60 ℃ of hot surveys;
5), in step 2) volatile oil of gained and the extractum of step 4) gained is 1 part, add about 0.1-0.5 part the granule adjuvant routinely formulation method make granule.
The preparation technology that formulation method can be routinely in the foregoing description, for example, the preparation process of Fan Biting " pharmacy of Chinese materia medica " (Shanghai Science Press 1997 December the 1st edition) record, make the acceptable any conventional dosage form of pharmaceutics, for example tablet, granule, capsule, buccal tablet, concentrated pill, drop pill etc.For described dosage form can be realized, need when these dosage forms of preparation, to add the pharmacy acceptable auxiliary, for example: filler, disintegrating agent, lubricant, suspending agent, binding agent, sweeting agent, correctives, antiseptic, substrate etc.Filler comprises: starch, pregelatinized Starch, lactose, mannitol, chitin, microcrystalline Cellulose, sucrose etc.; Disintegrating agent comprises: starch, pregelatinized Starch, microcrystalline Cellulose, carboxymethyl starch sodium, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose etc.; Lubricant comprises: magnesium stearate, sodium lauryl sulphate, Pulvis Talci, silicon dioxide etc.; Suspending agent comprises: polyvinylpyrrolidone, microcrystalline Cellulose, sucrose, agar, hydroxypropyl emthylcellulose etc.; Binding agent comprises, starch slurry, polyvinylpyrrolidone, hydroxypropyl emthylcellulose etc.; Sweeting agent comprises: saccharin sodium, Aspartane, sucrose, cyclamate, enoxolone etc.; Correctives comprises: sweeting agent and various essence; Antiseptic comprises: parabens, benzoic acid, sodium benzoate, sorbic acid and its esters, benzalkonium bromide, fixed, the Folium eucalypti globueli (Eucalyptus globulus Labill.) wet goods of acetic acid chloroethene; Substrate comprises: PEG6000, PEG4000, insect wax etc.
Listed examples of the present invention is intended to further illustrate compound mode of the present invention and processing method, and scope of the present invention is not constituted any restriction.

Claims (9)

1. Chinese medicine detoxicating preparation is characterized in that comprising that following raw medicaments in portion by weight makes: Fructus Forsythiae 10-30 part Radix Bupleuri 7-15 part Herba Menthae 4-12 part Fructus Arctii 7-15 part Rhizoma Cimicifugae 7-15 part Flos Chrysanthemi Indici 10-30 part Folium Isatidis 10-30 part Calyx Seu Fructus Physalis 10-30 part Rhizoma Fagopyri Dibotryis 7-15 part.
2. Chinese medicine detoxicating preparation according to claim 1 is characterized in that comprising that following raw medicaments in portion by weight makes: 7 parts of 10 parts of Rhizoma Fagopyri Dibotryiss of 10 parts of Calyx Seu Fructus Physaliss of 10 portions of Folium Isatidiss of 7 parts of Flos Chrysanthemi Indicis of 10 parts of Rhizoma Cimicifugaes of 4 parts of Fructus Arctiis of 7 portions of Herba Menthaes of 10 parts of Radix Bupleuri of Fructus Forsythiae.
3. Chinese medicine detoxicating preparation according to claim 1 is characterized in that comprising that following raw medicaments in portion by weight makes: 15 parts of 30 parts of Rhizoma Fagopyri Dibotryiss of 30 parts of Calyx Seu Fructus Physaliss of 30 portions of Folium Isatidiss of 15 parts of Flos Chrysanthemi Indicis of 15 parts of Rhizoma Cimicifugaes of 12 parts of Fructus Arctiis of 15 portions of Herba Menthaes of 20 parts of Radix Bupleuri of Fructus Forsythiae.
4. Chinese medicine detoxicating preparation according to claim 1 is characterized in that comprising that following raw medicaments in portion by weight makes: 12.5 parts of 15 parts of Rhizoma Fagopyri Dibotryiss of 25 parts of Calyx Seu Fructus Physaliss of 25 portions of Folium Isatidiss of 15 parts of Flos Chrysanthemi Indicis of 15 parts of Rhizoma Cimicifugaes of 12.5 parts of Fructus Arctiis of 15 portions of Herba Menthaes of 25 parts of Radix Bupleuri of Fructus Forsythiae.
5. Chinese medicine detoxicating preparation according to claim 1 is characterized in that comprising that following raw medicaments in portion by weight makes: 13 parts of 20 parts of Rhizoma Fagopyri Dibotryiss of 25 parts of Calyx Seu Fructus Physaliss of 22 portions of Folium Isatidiss of 15 parts of Flos Chrysanthemi Indicis of 12 parts of Rhizoma Cimicifugaes of 10 parts of Fructus Arctiis of 15 portions of Herba Menthaes of 10 parts of Radix Bupleuri of Fructus Forsythiae.
6. as the described Chinese medicine detoxicating preparation of each claim among the claim 1-5, it is characterized in that this Chinese medicine detoxicating preparation made by following method:
1), raw materials weighing medicine in proportion, clean respectively;
2), the medical material after will cleaning adds 6-10 times of water gaging, steam distillation extracts volatile oil, carries oil time 5-8 hour, volatile oil device is in addition collected, decocting liquid filters, and is standby;
3), the medicine residue that will carry behind the oil adds 8-12 water doubly, reflux, extract, 2 times, each 1.5 hours;
4), with step 2) the water extract of gained decocting liquid and step 3) merges, and is evaporated to the clear paste of 60 ℃ of heat relative density 1.10-1.20 when surveying, adding 95% ethanol to determining alcohol is 65%, left standstill 24 hours, and got supernatant, filter, decompression filtrate recycling ethanol is to there not being the alcohol flavor, and is standby;
Or be evaporated to the fluid extract of 60 ℃ of heat relative density 1.20-1.40 when surveying behind the recovery ethanol again, standby;
5), with step 2) volatile oil of gained and the filtration product of step 4) gained merge, formulation method is 1 part in said mixture routinely, adds 0-part oral formulations adjuvant and makes concentrated pill, tablet, capsule, granule or oral liquid.
7. according to of the application of the described Chinese medicine detoxicating preparation of claim 1-5, it is characterized in that as preparation treatment viral respiratory disease medicine: as the preparation treatment because the fear of cold that influenza virus causes, heating, headache, weak, nasal obstruction, watery nasal discharge, pharyngalgia or dry cough medicinal application.
8. Chinese medicine detoxicating preparation according to claim 8 is characterized in that as the application of preparation treatment viral respiratory disease medicine: as preparation treatment oral ulcer or acute pharyngitis medicinal application.
9. Chinese medicine detoxicating preparation according to claim 8 is characterized in that as the application of preparation treatment viral respiratory disease medicine: as the medicinal application of preparation treatment acute tonsillitis.
CNA2007101657010A 2007-01-16 2007-10-25 Chinese medicine detoxication preparations and preparation method thereof Pending CN101176765A (en)

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Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN 200710061420 CN100998690A (en) 2007-01-16 2007-01-16 Traditional Chinese medicine detoxification preparation and its preparing method
CN200710061420.0 2007-01-16
CNA2007101657010A CN101176765A (en) 2007-01-16 2007-10-25 Chinese medicine detoxication preparations and preparation method thereof

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101850043B (en) * 2008-07-31 2011-11-09 高川 Application of crex rigescens in preparation of medicament for resisting respiratory syncytial virus
CN105535117A (en) * 2016-01-13 2016-05-04 辽宁中医药大学 Detoxifying preparation for treating eczema

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101850043B (en) * 2008-07-31 2011-11-09 高川 Application of crex rigescens in preparation of medicament for resisting respiratory syncytial virus
CN105535117A (en) * 2016-01-13 2016-05-04 辽宁中医药大学 Detoxifying preparation for treating eczema

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