Summary of the invention
Technical problem to be solved by this invention provides Chinese medicine composition of a kind of acne and preparation method thereof; The present invention is directed to prior art, little, the taking convenience of product determined curative effect, toxic and side effects that provides.
Technical scheme of the present invention is to constitute like this: it is made up of following materials of weight proportions: Radix Arnebiae (Radix Lithospermi) 0.1-10, Radix Sophorae Flavescentis 0.1-10, Flos Campsis 0.1-10, Radix Paeoniae Rubra 0.1-10, Fructus Forsythiae 0.1-10, Flos Chrysanthemi Indici 0.1-10, Radix Et Rhizoma Rhei 0.05-5, Radix Angelicae Dahuricae 0.05-5.Be preferably: Radix Arnebiae (Radix Lithospermi) 5-10, Radix Sophorae Flavescentis 4-8, Flos Campsis 3-7, Radix Paeoniae Rubra 2-6, Fructus Forsythiae 2-6, Flos Chrysanthemi Indici 2-6, Radix Et Rhizoma Rhei 0.5-3, Radix Angelicae Dahuricae 0.5-3.More preferably: Radix Arnebiae (Radix Lithospermi) 7-9, Radix Sophorae Flavescentis 5-7, Flos Campsis 4-6, Radix Paeoniae Rubra 3-5, Fructus Forsythiae 3-5, Flos Chrysanthemi Indici 3-5, Radix Et Rhizoma Rhei 1-2, Radix Angelicae Dahuricae 1-2.
Radix Arnebiae (Radix Lithospermi) among the we, removing heat from blood is invigorated blood circulation, the detoxifcation rash; The Radix Sophorae Flavescentis heat clearing and damp drying, wind dispelling insecticide; Flos Campsis promoting the circulation of blood blood stasis removing, cooling blood, expelling wind; The Radix Paeoniae Rubra clearing away heat and cooling blood, eliminating stasis to stop pain; The Fructus Forsythiae heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, dispelling wind and heat pathogens; The Flos Chrysanthemi Indici heat-clearing and toxic substances removing, detumescence; The Radix Et Rhizoma Rhei purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation; Radix Angelicae Dahuricae expelling wind and cold, understand things pain-stopping, detumescence and apocenosis.
The screening of experimental example prescription
The influence of xylol induced mice auricle edema
Experimental technique faces with preceding makes decocting liquid with the present composition.Animal is used healthy Kunming mouse, body weight 20 grams.Mice is divided into 6 groups (matched group normal saline) at random, irritate the long-pending 20ml/kg of being of body of stomach, two weeks of continuous irrigation stomach, once a day, the last administration after 30 minutes with microsyringe only with 0.05ml/, dimethylbenzene is applied to mouse right ear, put to death mice after 15 minutes, cut two ears, dash with the 8mm diameter steel and lay round auricle in left and right sides auricle same area respectively along the auricle baseline, torsion balance claims two auricle weight in wet bases, with two auricle weight differences as the swelling level index.Inhibitory rate of intumesce equals the difference of average swelling degree of matched group and the average swelling degree of administration group and takes advantage of 100% again divided by the average swelling degree of matched group.
1 group of prescription: 5 parts of Radix Arnebiae (Radix Lithospermi)s, 4 parts of Radix Sophorae Flavescentiss, 3 parts of Flos Campsiss, 2 parts of Radix Paeoniae Rubra, 2 parts of Fructus Forsythiaes, 2 parts of Flos Chrysanthemi Indicis, 0.5 part of Radix Et Rhizoma Rhei, 0.5 part of the Radix Angelicae Dahuricae.
2 groups of prescriptions: 10 parts of Radix Arnebiae (Radix Lithospermi)s, 8 parts of Radix Sophorae Flavescentiss, 7 parts of Flos Campsiss, 6 parts of Radix Paeoniae Rubra, 6 parts of Fructus Forsythiaes, 6 parts of Flos Chrysanthemi Indicis, 3 parts of Radix Et Rhizoma Rhei, 3 parts of the Radixs Angelicae Dahuricae.
3 groups of prescriptions: 7 parts of Radix Arnebiae (Radix Lithospermi)s, 5 parts of Radix Sophorae Flavescentiss, 4 parts of Flos Campsiss, 3 parts of Radix Paeoniae Rubra, 3 parts of Fructus Forsythiaes, 3 parts of Flos Chrysanthemi Indicis, 1 part of Radix Et Rhizoma Rhei, 1 part of the Radix Angelicae Dahuricae.
4 groups of prescriptions: 9 parts of Radix Arnebiae (Radix Lithospermi)s, 7 parts of Radix Sophorae Flavescentiss, 6 parts of Flos Campsiss, 5 parts of Radix Paeoniae Rubra, 5 parts of Fructus Forsythiaes, 5 parts of Flos Chrysanthemi Indicis, 2 parts of Radix Et Rhizoma Rhei, 2 parts of the Radixs Angelicae Dahuricae.
5 groups of prescriptions: 7.5 parts of Radix Arnebiae (Radix Lithospermi)s, 6 parts of Radix Sophorae Flavescentiss, 5 parts of Flos Campsiss, 4 parts of Radix Paeoniae Rubra, 4 parts of Fructus Forsythiaes, 4 parts of Flos Chrysanthemi Indicis, 1.25 parts of Radix Et Rhizoma Rhei, 1.25 parts of the Radixs Angelicae Dahuricae.
Average swelling degree (mg) suppression ratio (%) of group dosage (g/kg) animal (only)
Matched group 20ml/kg 8 21.12 ± 1.11---
Hydrocortisone group 0.04 8 8.15 ± 0.22 61.41
Prescription 1 group 78 13.03 ± 1.20 38.30 of the present invention
Prescription 2 group 78 12.82 ± 2.01 39.30 of the present invention
Prescription 3 group 78 12.56 ± 1.22 40.53 of the present invention
Prescription 4 group 78 12.21 ± 1.34 42.19 of the present invention
Prescription 5 group 78 12.00 ± 2.06 43.18 of the present invention
The result shows that preparation of the present invention has good effect.
Concrete embodiment
Embodiments of the invention 1: 7.5 parts of Radix Arnebiae (Radix Lithospermi)s, 6 parts of Radix Sophorae Flavescentiss, 5 parts of Flos Campsiss, 4 parts of Radix Paeoniae Rubra, 4 parts of Fructus Forsythiaes, 4 parts of Flos Chrysanthemi Indicis, 1.25 parts of Radix Et Rhizoma Rhei, 1.25 parts of the Radixs Angelicae Dahuricae
Above flavour of a drug are got Radix Arnebiae (Radix Lithospermi), use 70% alcohol reflux, and Pericarpium Citri Reticulatae, Flos Chrysanthemi Indici extract volatile oil with steam distillation, medicinal residues decoct with water with the residue flavour of a drug, and collecting decoction filters, and filtrate decompression concentrates, standby, get above-mentioned volatile oil 3-cyclodextrin inclusion compound, clathrate and above-mentioned thick paste merge, vacuum drying, pulverize, add the starch of equivalent, mixing, granulate, after the drying, promptly get granule, oral, 3 times on the one, 3g/ time.
Embodiments of the invention 2: 0.1 part of Radix Arnebiae (Radix Lithospermi), 0.1 part of Radix Sophorae Flavescentis, 0.1 part of Flos Campsis, 0.1 part of Radix Paeoniae Rubra, 0.1 part of Fructus Forsythiae, 0.1 part of Flos Chrysanthemi Indici, 0.05 part of Radix Et Rhizoma Rhei, 0.05 part of the Radix Angelicae Dahuricae
Above flavour of a drug are got Radix Arnebiae (Radix Lithospermi), Flos Campsis ethanol extraction, and extracting solution reclaims ethanol, concentrate, standby, steam distillation extracts the volatile oil of Fructus Forsythiae, and the Fructus Forsythiae medical material after the extraction 5 distinguishes the flavor of in the lump that decocting boils secondary, collecting decoction together with other, filter, filtrate decompression concentrates, and merges vacuum drying with above-mentioned ethanol extract, pulverize, the adding consumption is 50% starch, sprays into volatile oil, mixing, sieve, after the drying, promptly get granule, oral, 2 times on the one, 3g/ time.
Embodiments of the invention 3: 10 parts of Radix Arnebiae (Radix Lithospermi)s, 10 parts of Radix Sophorae Flavescentiss, 10 parts of Flos Campsiss, 10 parts of Radix Paeoniae Rubra, 10 parts of Fructus Forsythiaes, 10 parts of Flos Chrysanthemi Indicis, 5 parts of Radix Et Rhizoma Rhei, 5 parts of the Radixs Angelicae Dahuricae
Above flavour of a drug are got Radix Arnebiae (Radix Lithospermi), Flos Campsis, Radix Paeoniae Rubra ethanol extraction, and extracting solution reclaims ethanol, concentrate, standby, steam distillation extracts the volatile oil of Fructus Forsythiae, and the Fructus Forsythiae medical material after the extraction 4 distinguishes the flavor of in the lump that decocting boils secondary, collecting decoction together with other, filter, filtrate decompression concentrates, and merges vacuum drying with above-mentioned ethanol extract, pulverize, the adding consumption is 50% starch, sprays into volatile oil, mixing, sieve, after the drying, promptly get granule, oral, 2 times on the one, 3g/ time.
Embodiments of the invention 4: 5 parts of Radix Arnebiae (Radix Lithospermi)s, 4 parts of Radix Sophorae Flavescentiss, 3 parts of Flos Campsiss, 2 parts of Radix Paeoniae Rubra, 2 parts of Fructus Forsythiaes, 2 parts of Flos Chrysanthemi Indicis, 0.5 part of Radix Et Rhizoma Rhei, 0.5 part of the Radix Angelicae Dahuricae
Above flavour of a drug decoct with water twice, add 6 times of water gagings for the first time and decoct 1 hour, add 4 times of water gagings for the second time, decoct 1 hour, and collecting decoction filters, and concentrate, and vacuum drying is pulverized; Get CMC-Na: PVPP: mannitol=add an amount of pigment mixing as pharmaceutical adjunct at 1: 1: 2, get 2/5 pharmaceutical adjunct and the medicated powder mix homogeneously that is equivalent to 10 times of amounts of CMC-Na approximately, PVP-K30 anhydrous alcohol solution with 2% is made binding agent, 40 order system material, granulate, remain 3/5 pharmaceutical adjunct, be added on outward in the particle that makes, tabletting promptly gets dispersible tablet.
Embodiments of the invention 5: 10 parts of Radix Arnebiae (Radix Lithospermi)s, 8 parts of Radix Sophorae Flavescentiss, 7 parts of Flos Campsiss, 6 parts of Radix Paeoniae Rubra, 6 parts of Fructus Forsythiaes, 6 parts of Flos Chrysanthemi Indicis, 3 parts of Radix Et Rhizoma Rhei, 3 parts of the Radixs Angelicae Dahuricae
Above flavour of a drug decoct with water twice, add 8 times of water gagings for the first time and decoct 2 hours, for the second time add 6 times of water gagings, decocted collecting decoction 2 hours, filter, relative density was 1.36 thick paste when filtrate decompression was concentrated into 60 ℃, vacuum drying, pulverize, cross 80 mesh sieves, press medication amount: substrate amount=1: 1.2 adding soybean oil, mixing, pill promptly gets soft capsule.
Embodiments of the invention 6: 7 parts of Radix Arnebiae (Radix Lithospermi)s, 5 parts of Radix Sophorae Flavescentiss, 4 parts of Flos Campsiss, 3 parts of Radix Paeoniae Rubra, 3 parts of Fructus Forsythiaes, 3 parts of Flos Chrysanthemi Indicis, 1 part of Radix Et Rhizoma Rhei, 1 part of the Radix Angelicae Dahuricae
Above flavour of a drug are got Radix Arnebiae (Radix Lithospermi), Flos Campsis, Radix Paeoniae Rubra ethanol extraction, and extracting solution reclaims ethanol, concentrate, standby, steam distillation extracts the volatile oil of Fructus Forsythiae, Flos Chrysanthemi Indici, and the Fructus Forsythiae after the extraction, Flos Chrysanthemi Indici medical material 3 distinguish the flavor of in the lump that decocting boils secondary, collecting decoction together with other, filter, filtrate decompression concentrates, and merges vacuum drying with above-mentioned ethanol extract, pulverize, the adding consumption is 50% starch, sprays into volatile oil, mixing, sieve, after the drying, promptly get granule, oral, 2 times on the one, 3g/ time.
Embodiments of the invention 7: 9 parts of Radix Arnebiae (Radix Lithospermi)s, 7 parts of Radix Sophorae Flavescentiss, 6 parts of Flos Campsiss, 5 parts of Radix Paeoniae Rubra, 5 parts of Fructus Forsythiaes, 5 parts of Flos Chrysanthemi Indicis, 2 parts of Radix Et Rhizoma Rhei, 2 parts of the Radixs Angelicae Dahuricae
Above flavour of a drug decoct with water three times, add 4 times of water gagings at every turn and decoct 1 hour, and collecting decoction filters, and concentrates, and promptly gets oral liquid.
9 parts of embodiment 8 Radix Arnebiae (Radix Lithospermi)s, 9 parts of Radix Sophorae Flavescentiss, 9 parts of Flos Campsiss, 8 parts of Radix Paeoniae Rubra, 8 parts of Fructus Forsythiaes, 8 parts of Flos Chrysanthemi Indicis, 5 parts of Radix Et Rhizoma Rhei, 4 parts of the Radixs Angelicae Dahuricae
Above flavour of a drug are got Radix Arnebiae (Radix Lithospermi), Radix Sophorae Flavescentis, Flos Campsis, Flos Chrysanthemi Indici, Radix Et Rhizoma Rhei ethanol extraction, and extracting solution reclaims ethanol, concentrate, standby, steam distillation extracts the volatile oil of Fructus Forsythiae, the Radix Angelicae Dahuricae, and the Fructus Forsythiae after the extraction, angelica root decoct with water secondary, collecting decoction in the lump together with Radix Paeoniae Rubra, filter, filtrate decompression concentrates, and merges vacuum drying with above-mentioned ethanol extract, pulverize, add the starch of equivalent, spray into volatile oil, mixing, sieve, after the drying, promptly get granule, oral, 2 times on the one, 3g/ time.
0.2 part of embodiment 9 Radix Arnebiae (Radix Lithospermi), 0.1 part of Radix Sophorae Flavescentis, 0.3 part of Flos Campsis, 0.2 part of Radix Paeoniae Rubra, 0.2 part of Fructus Forsythiae, 0.1 part of Flos Chrysanthemi Indici, 0.06 part of Radix Et Rhizoma Rhei, 0.05 part of the Radix Angelicae Dahuricae
Above flavour of a drug are got Radix Arnebiae (Radix Lithospermi), Flos Campsis ethanol extraction, and extracting solution reclaims ethanol, concentrate, standby, steam distillation extracts the volatile oil of Fructus Forsythiae, the Radix Angelicae Dahuricae, and the Fructus Forsythiae after the extraction, angelica root decoct with water secondary, collecting decoction in the lump together with other 4 flavors, filter, filtrate decompression concentrates, and merges vacuum drying with above-mentioned ethanol extract, pulverize, add an amount of starch, spray into volatile oil, mixing, sieve, after the drying, promptly get granule, oral, 2 times on the one, 3g/ time.
0.5 part of embodiment 10 Radix Arnebiae (Radix Lithospermi), 1 part of Radix Sophorae Flavescentis, 1 part of Flos Campsis, 1 part of Radix Paeoniae Rubra, 2 parts of Fructus Forsythiaes, 2 parts of Flos Chrysanthemi Indicis, 1 part of Radix Et Rhizoma Rhei, 2 parts of the Radixs Angelicae Dahuricae
Above flavour of a drug decoct with water three times, add 4 times of water gagings at every turn and decoct 1 hour, and collecting decoction filters, and concentrates, and promptly gets oral liquid.
1 part of embodiment 11 Radix Arnebiae (Radix Lithospermi), 2 parts of Radix Sophorae Flavescentiss, 3 parts of Flos Campsiss, 4 parts of Radix Paeoniae Rubra, 1 part of Fructus Forsythiae, 2 parts of Flos Chrysanthemi Indicis, 0.1 part of Radix Et Rhizoma Rhei, 2 parts of the Radixs Angelicae Dahuricae
Above flavour of a drug decoct with water twice, add 4 times of water gagings at every turn and decoct 2 hours, and collecting decoction filters, and concentrates, and promptly gets oral liquid.
3 parts of embodiment 12 Radix Arnebiae (Radix Lithospermi)s, 3 parts of Radix Sophorae Flavescentiss, 1 part of Flos Campsis, 2 parts of Radix Paeoniae Rubra, 4 parts of Fructus Forsythiaes, 1 part of Flos Chrysanthemi Indici, 1.5 parts of Radix Et Rhizoma Rhei, 3 parts of the Radixs Angelicae Dahuricae
Above flavour of a drug decoct with water twice, add 6 times of water gagings at every turn and decoct 2 hours, and collecting decoction filters, and concentrates, and promptly gets oral liquid.
8 parts of embodiment 13 Radix Arnebiae (Radix Lithospermi)s, 6 parts of Radix Sophorae Flavescentiss, 5 parts of Flos Campsiss, 4 parts of Radix Paeoniae Rubra, 4 parts of Fructus Forsythiaes, 4 parts of Flos Chrysanthemi Indicis, 1.5 parts of Radix Et Rhizoma Rhei, 1.5 parts of the Radixs Angelicae Dahuricae
Above flavour of a drug decoct with water twice, add 4 times of water gagings at every turn and decoct 2 hours, and collecting decoction filters, and concentrates, and promptly gets oral liquid.
6 parts of embodiment 14 Radix Arnebiae (Radix Lithospermi)s, 7 parts of Radix Sophorae Flavescentiss, 5 parts of Flos Campsiss, 3 parts of Radix Paeoniae Rubra, 3 parts of Fructus Forsythiaes, 3 parts of Flos Chrysanthemi Indicis, 1 part of Radix Et Rhizoma Rhei, 2 parts of the Radixs Angelicae Dahuricae
Above flavour of a drug decoct with water twice, add 4 times of water gagings at every turn and decoct 2 hours, and collecting decoction filters, and concentrates, and promptly gets oral liquid.
8 parts of embodiment 15 Radix Arnebiae (Radix Lithospermi)s, 7 parts of Radix Sophorae Flavescentiss, 5 parts of Flos Campsiss, 4 parts of Radix Paeoniae Rubra, 3 parts of Fructus Forsythiaes, 4 parts of Flos Chrysanthemi Indicis, 0.5 part of Radix Et Rhizoma Rhei, 2 parts of the Radixs Angelicae Dahuricae
Above flavour of a drug decoct with water twice, add 4 times of water gagings at every turn and decoct 2 hours, and collecting decoction filters, and concentrates, and promptly gets oral liquid.
1.5 parts of embodiment 16 Radix Arnebiae (Radix Lithospermi)s, 1.5 parts of Radix Sophorae Flavescentiss, 1.5 parts of Flos Campsiss, 1 part of Radix Paeoniae Rubra, 1 part of Fructus Forsythiae, 1 part of Flos Chrysanthemi Indici, 0.3 part of Radix Et Rhizoma Rhei, 0.5 part of the Radix Angelicae Dahuricae
Above flavour of a drug decoct with water twice, add 4 times of water gagings at every turn and decoct 2 hours, and collecting decoction filters, and concentrates, and promptly gets oral liquid.
2 parts of embodiment 17 Radix Arnebiae (Radix Lithospermi)s, 2 parts of Radix Sophorae Flavescentiss, 1 part of Flos Campsis, 7 parts of Radix Paeoniae Rubra, 8 parts of Fructus Forsythiaes, 9 parts of Flos Chrysanthemi Indicis, 4 parts of Radix Et Rhizoma Rhei, 3 parts of the Radixs Angelicae Dahuricae
Above flavour of a drug are got Radix Arnebiae (Radix Lithospermi), Radix Sophorae Flavescentis, Flos Campsis, Flos Chrysanthemi Indici, Radix Et Rhizoma Rhei ethanol extraction, and extracting solution reclaims ethanol, concentrate, standby, steam distillation extracts the volatile oil of Fructus Forsythiae, and the Fructus Forsythiae medical material after the extraction decocts with water secondary, collecting decoction together with other 2 flavor medical materials, filter, filtrate decompression concentrates, and merges vacuum drying with above-mentioned ethanol extract, pulverize, the adding consumption is 50% starch, sprays into volatile oil, mixing, sieve, after the drying, promptly get granule, oral, 2 times on the one, 3g/ time.
2 parts of embodiment 18 Radix Arnebiae (Radix Lithospermi)s, 2 parts of Radix Sophorae Flavescentiss, 2 parts of Flos Campsiss, 1 part of Radix Paeoniae Rubra, 1 part of Fructus Forsythiae, 1 part of Flos Chrysanthemi Indici, 0.3 part of Radix Et Rhizoma Rhei, 1 part of the Radix Angelicae Dahuricae
Above flavour of a drug are got Radix Arnebiae (Radix Lithospermi), Radix Sophorae Flavescentis, Flos Campsis, Flos Chrysanthemi Indici, Radix Et Rhizoma Rhei, Radix Paeoniae Rubra ethanol extraction, and extracting solution reclaims ethanol, concentrate, standby, steam distillation extracts the volatile oil of Fructus Forsythiae, the Radix Angelicae Dahuricae, and Fructus Forsythiae, angelica root after the extraction decoct with water secondary, collecting decoction, filter, filtrate decompression concentrates, and merges vacuum drying with above-mentioned ethanol extract, pulverize, the adding consumption is 50% starch, sprays into volatile oil, mixing, sieve, after the drying, promptly get granule, oral, 2 times on the one, 3g/ time.