CN1814194A - Chinese-western medicine composition for treating in fant's common cold and use thereof - Google Patents
Chinese-western medicine composition for treating in fant's common cold and use thereof Download PDFInfo
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- CN1814194A CN1814194A CN 200510061807 CN200510061807A CN1814194A CN 1814194 A CN1814194 A CN 1814194A CN 200510061807 CN200510061807 CN 200510061807 CN 200510061807 A CN200510061807 A CN 200510061807A CN 1814194 A CN1814194 A CN 1814194A
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Abstract
The invention discloses a Chinese-Western medicinal combination for curing infantile cold and the application thereof, prepared of Chrysanthemum Hang, Honeysuckle Flower, Reed Rhizome, Vitamin C, etc, by the steps of: weighing all raw materials in proportion, taking Chrysanthemum Hang, Honeysuckle Flower, and Reed Rhizome and decocting with water thrice, boiling for 1 hour each time, combining the decoctions, filtering, concentrating the filtrate into plaster, adding in proper amount of starch, making granules, drying, adding in Vitamin C and French chalk of 5%, fully mixing, tableting, sugarcoating, and making sugarcoated tablets. And long-term research and prectcie show that it has characters of scientific formula, being elaborated, advanced process, giving full play to fast curative effect of the Western medicine and no side effect of traditional Chinese medicine, and being able to prohibit the side effect of the Western medicine by traditional Chinese medicine, and remarkable curative effect as well as low price, etc. It is to be orally taken, convenient to use, tasting good, and easy to be accepted by patients.
Description
Technical field
The present invention relates to a kind of compound preparation and promptly treat the Chinese and western medicinal composition and the application thereof of infantile common cold.Pneumonia, upper respiratory tract infection, tonsillitis, pharyngitis and the heating that causes because of antibacterial and viral infection especially for treatment, pharyngalgia, cough, etc. the anti-flu compound recipe Chinese-western medicine preparation of disease.
Background technology
Infantile common cold is a kind of the most common and multiple disease.The medicine of treatment also has the number of chemical medicine except that traditional natural drugs such as Chinese medicine.The former effect is slow, though latter's effect is very fast, can produce some side effect.Therefore, the present invention is directed to the deficiency of above-mentioned technology, through long term studies and practice, scientific composition is made meticulously, and technology advanced person can bring into play the speciality that Western medicine curative effect speed is fast, Chinese medicine has no side effect, and can make full use of the inhibition of Chinese medicine to the Western medicine side effect again; The two Chinese and Western combination, effect is remarkable, and is stretched and relaxed, overcome the two deficiency of Chinese medicine and Western medicine, is in particular that vast pediatric patient provides good effect, speed is fast, price is low, has no side effect and gratifying flu medication.
Summary of the invention
Purpose of the present invention aims to provide and a kind ofly can either play fine treatment or relief of symptoms effect to infantile common cold, have advantages such as good effect, speed is fast, price is low, have no side effect, a kind of Chinese and western medicinal composition that can make the patient not have the psychology burden, take like a shot again.The present invention is according to understanding and the Therapeutic Principle of Chinese and western medicine to infantile common cold, scientific composition, and development meticulously realizes by following technical scheme.
The consumption of drug component of the present invention is groped to sum up to draw through the inventor in a large number, and each amounts of components all has curative effect preferably in following ranges, and medicine of the present invention contains
3～9 parts of 55～166 parts of vitamin Cs of 155～465 parts of Rhizoma Phragmitiss of 331～999 portions of Flos Loniceraes of Flos Chrysanthemi
Preferable range is:
9～18 parts of 165～496 parts of vitamin Cs of 331～499 parts of Rhizoma Phragmitiss of 498～998 portions of Flos Loniceraes of Flos Chrysanthemi
Optimum weight part is:
11 parts of 111 parts of vitamin Cs of 331 parts of Rhizoma Phragmitiss of 662 portions of Flos Loniceraes of Flos Chrysanthemi
Technical problem to be solved by this invention is to realize by following technical scheme.Be characterized in that with Flos Chrysanthemi, Flos Lonicerae, Rhizoma Phragmitis, vitamin C etc. be the medicine that raw material is made.The pharmaceutical composition of this treatment infantile common cold is characterized in that it is that component is formed or made active component and pharmaceutically acceptable additives are formed or make active component and pharmaceutically acceptable additives are formed by the alcohol extract of following main materials by the water extract of following main materials by following main materials.The present invention has antiinflammatory, analgesic, analgesic activity by scientific combination, development meticulously, the popularity flu, and disease effects such as upper respiratory tract infection are particularly remarkable.
Described pharmaceutically acceptable additives are following one or more: Pulvis Talci, glycerol, gelatin, Polyethylene Glycol, propylene glycol, dextrin, ethanol, dried starch, citric acid, sodium bicarbonate, ethyl hydroxybenzoate, tartaric acid, lecithin, sodium lauryl sulphate.
Its dosage form can be a said dosage form on any pharmaceutics, as syrup, granule, capsule, tablet etc.; Described capsule can be common capsule, effervescent capsule or other various suitable capsules; Described tablet can be common tablet, effervescent tablet, dispersible tablet or other various suitable tablets, can be with suitable coating material coating also coating not; Preferred tablet.
The specific embodiment
Describe implementation of the present invention in detail below in conjunction with embodiment.
Embodiment 1:
The preparation method of tablet of the present invention:
Take by weighing Flos Chrysanthemi 662 grams, Flos Lonicerae 331 grams, Rhizoma Phragmitis 111 grams, vitamin C 5.2 grams, standby by weight.Get Flos Chrysanthemi, Flos Lonicerae, Rhizoma Phragmitis water and decoct and boiled 1 hour three first time, respectively boiled 1 hour for the second time, for the third time, merge decoction liquor, filter, filtrate is concentrated into the thick paste shape, adds appropriate amount of starch, granulates, oven dry, add shape vitamin C, chlorphenamine, aspirin, 5% Pulvis Talci, abundant mixing, tabletting, sugar coating is made coated tablet.
Embodiment 2:
The preparation method of capsule of the present invention:
It is standby to take by weighing Flos Chrysanthemi 666 gram, Flos Lonicerae 333 grams, Rhizoma Phragmitis 111 grams, vitamin C 5.5 grams by weight.Get Flos Chrysanthemi, Flos Lonicerae, Rhizoma Phragmitis water and decoct and boiled 1 hour three first time, respectively boiled 1 hour for the second time, for the third time, merge decoction liquor, filter, filtrate is concentrated into the thick paste shape, adds ethanol precipitation once, makes to contain alcohol amount and reach 65%, standing over night, filter, decompression recycling ethanol also is concentrated into the thick paste shape, adds appropriate amount of starch, granulate dry for standby; Add vitamin C, 3% Pulvis Talci,, make capsule with the abundant mixing of above-mentioned granule.
In like manner, press the method for embodiment 1, make suitable granule etc.
More than during each forms, weight is calculated with crude drug, in the present invention, if weight is unit with the gram, this composition can be made into 1000 doses of pharmaceutical preparatioies, described 1000 doses of fingers, 1000 doses in the final drug preparation of making, as make 1000 in 1000 of capsule preparations, 1000 in tablet, granule 1000g, oral liquid 1000 peace bottles, injection 1000 peace bottles, drop pill etc., also can make big packing as granule, as 100500 bags, specifically can be 100 bags, 150 bags, 200 bags, 250 bags, 500 bags, every bag can be used as dose 1 time.This weight of formulation can increase or reduce, but the raw medicinal herbs weight proportion constant rate between each composition.
For a better understanding of the present invention, below further set forth the action effect of medicine of the present invention in clinical experiment, but not to the restriction of effect of the present invention.
(1) experiment material:
1, experiment medicine: little 13 anti-influenza tablets of the present invention, oral, each 4,3 times on the one medicines
2, laboratory animal: Kunming mouse, Zhejiang medical courses in general institute zoopery center provides.
(2) antitussive experiment:
30 of Kunming mouses, male and female dual-purpose, body weight 18～20g divide 3 groups at random. and 10 every group, irritate stomach respectively and give drug solution of the present invention, high dose 30ml/kg. low dose group matched group 10ml/kg; Capacity water such as matched group, once a day, continuous three days.After the last administration 30 minutes, by only Mus being put into glass bell jar, from bell jar long 10cm, the wide 1.5cm filter paper bar put into suitable for reading, drip 0.5ml ammonia above, airtight, the cough latent period of mice behind the observation suction ammonia, whenever change a Mus, change a filter paper bar, whenever all drip 0.5ml ammonia, experimental result sees Table 1.
The antitussive action of table 1 children's anti-influenza tablet (X ± SD)
| Group | The example number | Dosage (ml/kg) | Cough latent period |
| Matched group high dose group low dose group | 10 10 10 | / 30 10 | 90±28.42 168.48±26.68 ** 112.25±18.86 * |
With the matched group ratio
*P＜0.05
*P＜0.01
T check between group: high low dose group antitussive effect all has the significance meaning, P＜0.01 and P＜0.05.
(3), the experiment of eliminating the phlegm: 30 of Kunming mouses, body weight 18～20g divide 3 groups at random. and 10 every group, irritate stomach respectively and give anti-influenza tablet solution, high dose 30ml/kg. low dose group matched group 10ml/kg; Capacity water such as matched group, once a day, continuous three days.After the last administration 30 minutes, every Mus lumbar injection 0.5% phenol red 0.5ml was after half an hour.Take off cervical vertebra and put to death mice, face upward the position and be fixed on the operation plate, cut off neck center skin, separate trachea, under larynx injection needle is inserted trachea, ligation is fixed, draw 5% carbonate ammonia natrium solution 0.5ml. flushing respiratory tract three times with syringe. amount to flushing three times, totally nine times.Each flushing liquor is put into test tube, with 751 ultraviolet spectrophotometer colorimetrics.Experimental result sees Table 2.
Table 2: the phlegm-dispelling functions of children's's anti-influenza tablet (X ± SD)
| Group | The example number | Dosage (ml/kg) | Phenol red output (μ g) |
| Matched group high dose group low dose group | 10 10 10 | / 30 10 | 1.22±0.52 2.98±1.01 ** 1.92±0.68 * |
With the matched group ratio
*P＜0.05
*P＜0.01
T check between group, high low dose group is eliminated the phlegm all has the significance meaning (P＜0.01 and P＜0.05)
Experiment conclusion:, confirm that children's's anti-influenza tablet has tangible cough-suppressing phlegm-dispelling functions by the relieving cough and expelling phlegm experiment.
(4) clinical verification:
The checking of first hospital clinical is contrast with " Shuan Huang Even oral liquid " through Zhejiang Province, and 148 routine children's patients are treated observation.Its criterion: the three days clinical symptoms of taking medicine are partly alleviated and are produce effects, and the three days clinical symptoms of taking medicine disappearance person substantially are recovery from illness.Its healing situation sees Table 3.
Table 3. clinical test results is as follows:
| Clinical | Recovery from illness | Produce effects | Invalid | Total effective rate (%) |
| Treatment group matched group | 114 95 | 24 34 | 10 21 | 93.2 86 |
The present invention is through long term studies and practice, and the prescription science is made meticulously, and technology advanced person can bring into play the speciality that Western medicine curative effect speed is fast, Chinese medicine has no side effect, and can make full use of the inhibition of Chinese medicine to the Western medicine side effect again; The two Chinese and Western combination, clinical and experimental study explanation: this invention effect is remarkable, has overcome the two deficiency of Chinese medicine and Western medicine, really for vast pediatric patient provides good effect, speed is fast, price is low, have no side effect and gratifying flu medication.
Claims (6)
1, a kind of Chinese and western medicinal composition and application thereof for the treatment of infantile common cold, it is characterized in that it is that component is formed or made active component and pharmaceutically acceptable additives are formed or make active component and pharmaceutically acceptable additives are formed by the alcohol extract of following main materials by the water extract of following main materials by following main materials: the consumption of drug component of the present invention is groped to sum up to draw through the inventor in a large number, each amounts of components all has curative effect preferably in following ranges, and medicine of the present invention contains
3～9 parts of 55～166 parts of vitamin Cs of 155～465 parts of Rhizoma Phragmitiss of 331～999 portions of Flos Loniceraes of Flos Chrysanthemi.
2, pharmaceutical composition according to claim 1 is characterized in that the formula optimization scope is:
9～18 parts of 165～496 parts of vitamin Cs of 331～499 parts of Rhizoma Phragmitiss of 498～998 portions of Flos Loniceraes of Flos Chrysanthemi.
3, pharmaceutical composition according to claim 1, optimum weight part is:
11 parts of 111 parts of vitamin Cs of 331 parts of Rhizoma Phragmitiss of 662 portions of Flos Loniceraes of Flos Chrysanthemi.
4, pharmaceutical composition according to claim 1 is characterized in that: described pharmaceutically acceptable additives are following one or more: glycerol, gelatin, Polyethylene Glycol, glycerol, laurate (gelucire44/14), propylene glycol, dextrin, dried starch, ethylparaben, tartaric acid, citric acid, sodium bicarbonate, lecithin, sodium lauryl sulphate.
5, preparation of drug combination method as claimed in claim 1 is characterized in that comprising the steps:
It is standby to take by weighing Flos Chrysanthemi, Flos Lonicerae, Rhizoma Phragmitis, vitamin C by weight.Get Flos Chrysanthemi, Flos Lonicerae, Rhizoma Phragmitis water and decoct and boiled 1 hour three first time, respectively boiled 1 hour for the second time, for the third time, merge decoction liquor, filter, filtrate is concentrated into the thick paste shape, adds appropriate amount of starch, granulates, oven dry, add shape vitamin C, chlorphenamine, aspirin, 5% Pulvis Talci, abundant mixing, tabletting, sugar coating is made coated tablet.
6, pharmaceutical composition according to claim 1 is characterized in that: its dosage form can be a said dosage form on any pharmaceutics, as effervescent granule electuary, capsule, tablet etc.; Described capsule can be common capsule, effervescent capsule or other various suitable capsules; Described tablet can be common tablet, effervescent tablet, dispersible tablet or other various suitable tablets, can be with suitable coating material coating also coating not; Preferred tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510061807 CN1814194B (en) | 2005-12-05 | 2005-12-05 | Chinese-western medicine composition for treating infant's common cold and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510061807 CN1814194B (en) | 2005-12-05 | 2005-12-05 | Chinese-western medicine composition for treating infant's common cold and preparation method thereof |
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| Publication Number | Publication Date |
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| CN1814194A true CN1814194A (en) | 2006-08-09 |
| CN1814194B CN1814194B (en) | 2011-02-16 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102302688A (en) * | 2011-08-25 | 2012-01-04 | 暨南大学 | Traditional Chinese medicine used for treating influenza caused by damp toxin, and preparation method thereof |
| CN107519405A (en) * | 2017-08-17 | 2017-12-29 | 张桂英 | A kind of beverage for being used to preventing and treating flu |
| CN108853371A (en) * | 2018-08-23 | 2018-11-23 | 曾继仁 | Reed root is preparing the application in the antipyretic for treating fever caused by acute upper respiratory infection |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1057451C (en) * | 1994-08-16 | 2000-10-18 | 欧致新 | Children coryza medicine and preparing method |
| CN1689613A (en) * | 2004-04-30 | 2005-11-02 | 熊少希 | Prescription and preparation of product for preventing and treating wind-heat type cold and virus infected cold |
| CN1660275A (en) * | 2004-12-25 | 2005-08-31 | 贵阳云岩西创药物科技开发有限公司 | 'Ganmaoning' gel preparation for enfant and preparation method |
-
2005
- 2005-12-05 CN CN 200510061807 patent/CN1814194B/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102302688A (en) * | 2011-08-25 | 2012-01-04 | 暨南大学 | Traditional Chinese medicine used for treating influenza caused by damp toxin, and preparation method thereof |
| CN102302688B (en) * | 2011-08-25 | 2013-06-12 | 暨南大学 | Traditional Chinese medicine used for treating influenza caused by damp toxin, and preparation method thereof |
| CN107519405A (en) * | 2017-08-17 | 2017-12-29 | 张桂英 | A kind of beverage for being used to preventing and treating flu |
| CN108853371A (en) * | 2018-08-23 | 2018-11-23 | 曾继仁 | Reed root is preparing the application in the antipyretic for treating fever caused by acute upper respiratory infection |
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| Publication number | Publication date |
|---|---|
| CN1814194B (en) | 2011-02-16 |
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Granted publication date: 20110216 Termination date: 20131205 |