CN1966052A - Tablet containing red sage root and astragalus root for removing blood stasis and preparation process thereof - Google Patents
Tablet containing red sage root and astragalus root for removing blood stasis and preparation process thereof Download PDFInfo
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- CN1966052A CN1966052A CN 200510047765 CN200510047765A CN1966052A CN 1966052 A CN1966052 A CN 1966052A CN 200510047765 CN200510047765 CN 200510047765 CN 200510047765 A CN200510047765 A CN 200510047765A CN 1966052 A CN1966052 A CN 1966052A
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Abstract
The invention provides tablets for removing stasis and process for preparation, wherein the constituents include astragalus root 150 parts, radix salvia miltiorrhiza 150 parts, root of pilose asiabell 75 parts, Chinese yam 75 parts, rhizome smilacis glabrae 100 parts, Chinese angelica root 75 parts, spatholobus stem 150 parts, gorgon euryale seed 75 parts, cordate houttuynia 150 parts, burred tuber 15 parts, herba patriniae 150 parts, Cinnamomum cassia 15 parts, white atractylodes rhizome 45 parts, ginger 22.5 parts, toosendan fruit 45 parts, flavescent sophora root 75 parts, buthus martensi kirsch 75 parts, zedoary 45 parts, ground beetle 75 parts, corydalis tuber 75 parts, the preparing process consists of steps of grinding, water grilling, concentrating into concrete, charging findings and medicinal powders, granulating, tabletting, dressing, quality inspecting and packaging.
Description
Technical field: the present invention relates to tablet that 20 flavor Chinese medicines such as the Radix Astragali make and the process of this tablet of making, relate in particular to red astragalus root for removing blood stasis sheet and preparation method.
Background technology: tablet is a pharmaceutical formulation the most frequently used in the preparation, according to the relevant drug act of China, change dosage form as a kind of new drug research, original dosage form of red astragalus root for removing blood stasis sheet is a capsule, record in " national standard for traditional Chinese medicines compilation " (Chinese patent medicine provincial standard rising national standard part surgery gynecological fascicle), the technology characteristics of former dosage form is: Scorpio in the prescription, Eupolyphaga Seu Steleophaga, Rhizoma Corydalis, Rhizoma Curcumae is dried and crushed into fine powder, all the other 16 flavor medicines decoct with water 2-4 time, each 1-4 hour, collecting decoction, filter, concentrate, with the medicated powder and the concentrated solution mixing of pulverizing such as above-mentioned Scorpio, encapsulated forming behind the drying and granulating.This capsule contains the water extracted immersing paste of the more very easily moisture absorption, and the easy moisture absorption in preparation, storage and transportation influences the stability of medicine.Therefore we plan former capsule and change the film-coat slow releasing tablet into.Compare with capsule, film coated tablet has that humidity resistance is good, supplementary product consumption is few, dose is little, divided dose is accurate, transportation is easy to carry, make slow releasing tablet in addition and can reduce administration number of times, by being kept to twice of medication every day 3 times every day, avoid the administration peak valley phenomenon, be fit to plurality of advantages such as more patient takes.Based on this, we use the modern pharmaceutical technology this product technology are done necessary improvement, form new preparation, and the control criterion that improves the quality simultaneously guarantees the quality of product, and the assurance drug effect is benefited the common people.
Summary of the invention:
Purpose of the present invention will solve the easy moisture absorption of this prior art Chinese medicine exactly, influences the problem of the stability of medicine, provides a kind of and improves the quality of products and curative effect, increases the red astragalus root for removing blood stasis slow releasing tablet and the preparation method of the stability of product.
Red astragalus root for removing blood stasis sheet of the present invention and preparation method are to be made of 150 parts of the Radixs Astragali, 150 parts of Radix Salviae Miltiorrhizaes, 75 parts of Radix Codonopsis, 75 parts of Rhizoma Dioscoreaes, 100 parts of Rhizoma Smilacis Glabraes, 75 parts of Radix Angelicae Sinensis, 150 parts of Caulis Spatholobis, 75 parts of Semen Euryaless, 150 parts of Herba Houttuyniae, 15 parts of rhizoma sparganic, 150 parts of Herba Patriniae, 15 parts of Cortex Cinnamomis, 45 parts of the Rhizoma Atractylodis Macrocephalaes, 22.5 parts of Rhizoma Zingiberis Preparatums, 45 parts of toosendan fruits, 75 parts of Radix Sophorae Flavescentiss, 75 parts of Scorpios, 45 parts of Rhizoma Curcumae, 75 parts of Eupolyphaga Seu Steleophagas, 75 parts of these 20 flavor medicines of Rhizoma Corydalis.Back four Chinese medicine grinds into powder, and all the other ten Six-element medicines decoct with water and are condensed into extractum and grind powder mix homogeneously, drying, be ground into fine powder with four Chinese medicine, add auxiliary materials and mixing again, and granulations, drying, granulate, tabletting, coating, quality inspection are packed promptly.The present invention preferably ten Six-element medicines decocts with water three times, adds 10 times of water gagings for the first time, and second and third time adds 8 times of water gagings respectively, decocting time was followed successively by 3 hours, 2 hours, 1 hour, filter, merging filtrate, being concentrated into relative density is the clear paste of 1.28～1.30 (60 ℃); With fine powder mixing such as above-mentioned Scorpio, drying under reduced pressure is ground into fine powder, adds carboxymethylstach sodium, starch, and mixing use 80% alcohol granulation, drying, and granulate, the adding magnesium stearate, mixing, tabletting, bag film-coat, quality inspection are packed promptly.Perhaps the present invention preferably ten Six-element medicines decoct with water 2-4 time, each 1-4 hour, collecting decoction, filter, be concentrated into relative density and be fine powder mix homogeneously, dryings such as the clear paste of 1.05-1.35 (60 ℃) and above-mentioned Scorpio, be ground into fine powder, add an amount of hydrophilic gel matrix tablet HPMC (K4M) mixing, make soft material as wetting agent with 80% ethanol, granulation, drying, granulate, tabletting, coating, quality inspection, packing promptly.
By above-mentioned technology gained is red astragalus root for removing blood stasis slow releasing tablet of the present invention.
The added adjuvant of red astragalus root for removing blood stasis slow releasing tablet can be that any or multiple mixing in HPMC, carboxymethyl starch sodium, starch, hypromellose, microcrystalline Cellulose, Pulvis Talci, magnesium stearate, the coating powder etc. is used.
Being ground into fine powder in the technology was 80～120 purpose fine powders, and the best was 100 purpose fine powders, was ground into coarse powder, decoction pieces in the technology for being ground into 10～20 orders, and the best was 14～16 orders.
The preparation of matrix sustained release tablet agent in the technology: the addition of hydrophilic gel matrix tablet HPMC is 50～90g, and specification should be more than 4000cPas; Optimal addn is 70～80g, and specification is K4M.
Decocting boils or the condition of water steaming and decocting is in the technology; Amount of water is the amount of 10 times of the first time, and second is 8 times amount for the third time, decocts 3 times, and the time was followed successively by 3 hours, 2 hours, 1 hour.
The density that is condensed into clear paste in the technology is that the best relative density of 1.20～1.35 (60 ℃) is 1.28～1.30 (60 ℃).
The spray drying inlet temperature is 150～200 ℃ in the technology, and leaving air temp is 50～150 ℃, and best inlet temperature is 150～170 ℃, and the optimum temperature of air-out is 70～75 ℃, and the temperature of particle drying is controlled at 55 ± 5 ℃ and is preferably 62 ℃ in the technology.
This invention its superiority compared with the prior art is: the qualitative, quantitative control method that dosage form manufacturing technique more becomes fully rationally, product has more comprehensive science, suitable more patient takes, quality has had better guarantee.With red astragalus root for removing blood stasis sheet treatment chronic pelvic inflammatory disease 56 examples of the present invention, receive better curative effect, clinical trial is as follows:
Clinical data
1. this group of physical data chronic pelvic inflammatory disease 97 examples are the married women that the motherhood history is arranged, 22～42 years old age, average 36 years old; The course of disease is the longest 6 years, and is the shortest 2 months, maximum with 3 months～4 years persons, accounts for 62.7%.97 examples are divided into two groups at random, wherein treatment group (A) 56, matched group (B) 41 examples.
2. diagnostic criteria chronic pelvic inflammatory disease has lower abdomen dull pain, saddle sacrum portion to weigh down pain, many three cardinal symptoms of leucorrhea, often with menoxenia, insomnia, dizziness, low grade fever, fatiguability, infertile and characteristics that the course of disease is long, this group case all has wherein 2 above cardinal symptoms and 2 above concomitant symptoms, pelvioscopy, uterus often are the position, back, and tenderness is arranged, limitation of activity, or the other tissue of adnexa, palace increases slightly and thickens, or touches enclosed mass, and tenderness is arranged.
3. Therapeutic Method (1) treatment group: 3 of red astragalus root for removing blood stasis sheets 1 time, 3 times on the 1st, 10 days is 1 course of treatment, 2～3 courses of treatment of continuous application; (2) matched group: quiet 0.2% metronidazole injection 250ml, every day 2 times, ampicillin 2.0g adds 5% glucose 250ml intravenous drip, and every day 2 times, 10 days is 1 course of treatment, 2～3 courses of treatment of continuous application.
The result
1. criterion of therapeutical effect recovery from illness: symptom, sign all disappear; Produce effects: symptom, sign are significantly improved, and inflammation is most of to be absorbed, and enclosed mass obviously dwindles; Take a turn for the better: symptom and sign alleviate to some extent; Invalid: the equal no change of symptom and sign.
Table 1 efficacy assessment standard
| Evaluation criteria | Following soreness of waist dull pain | Lower abdomen weighs down distending pain | Leucorrhoea grow in quantity | Cervical hypertrophy hyperemia | General malaise | Menoxenia | Low grade fever | Dyspareunia | The adnexa enclosed mass |
| It is invalid that the recovery from illness produce effects takes a turn for the better | Disappear obviously to alleviate to alleviate slightly not have and alleviate | Disappear obviously to alleviate to alleviate slightly not have and alleviate | Normal minimizing is many | Disappearance alleviates and alleviates still hyperemia slightly | Disappear to alleviate slightly not have and change | Normal basic normal nothing changes | Disappear not have and change | Disappear not have and change | Disappearance reduces to touch a tender spot gently not have and changes |
2. statistical procedures: adopt the SPSS software kit to carry out statistical procedures.
3. the relation of the therapeutic outcome course of treatment and curative effect: 1,2 the course of treatment total effective rate A group highly significant be higher than B group (X
2=9.24 and 7.64, P＜0.01), and the 3rd the course of treatment total effective rate A group also be significantly higher than B group (X
2=4.53, P＜0.05), see Table 1.The clinical improvements situation: the improvement rate A group for the treatment of every symptom after 1 course of treatment all is significantly higher than B group (X
2=4.67～9.15, P＜0.05 or＜0.01) see Table 2.
The relation of the table 2 liang group course of treatment and curative effect
| The course of treatment | Group | The example number | Recovery from illness | Produce effects | Effectively | Invalid | Effectively total | |||||
| The example number | ％ | The example number | ％ | The example number | ％ | The example number | ％ | The example number | ％ | |||
| 1 | A | 56 | 12 | 21.43 | 18 | 32.12 | 15 | 26.79 | 11 | 19.64 | 45 | 80.36 *△△ |
| B | 41 | 4 | 9.76 | 9 | 21.95 | 8 | 19.51 | 20 | 48.78 | 21 | 51.22 | |
| 2 | A | 42 | 8 | 19.05 | 15 | 35.71 | 15 | 35.71 | 4 | 9.52 | 38 | 90.48 *△△ |
| B | 37 | 3 | 8.11 | 8 | 21.62 | 13 | 35.14 | 13 | 35.14 | 24 | 64.86 | |
| 3 | A | 30 | 12 | 40.00 | 9 | 30.00 | 8 | 26.67 | 1 | 3.33 | 29 | 96.67△ |
| B | 33 | 6 | 18.18 | 12 | 36.36 | 8 | 24.24 | 7 | 21.21 | 26 | 78.79 | |
Annotate: two groups of total effective rates compare Δ P＜0.05, * P＜0.01
The comparison of two groups of clinical improvements situations after 1 course of treatment of table 3 treatment
| Symptom | Group | The example number | Improve number | Improvement rate (%) | X 2 | P |
| The swollen leucorrhea increasing menstrual disorder pelvioscopy of stomachache waist sacrum pendant | A B A B A B A B A B | 48 34 42 30 37 24 28 19 56 41 | 42 20 36 16 33 16 23 10 50 26 | 87.50 58.82 85.71 53.33 89.19 66.67 82.14 52.63 90.00 63.89 | 8.87 9.15 4.67 4.71 8.62 | ＜0.01 ＜0.01 ＜0.05 ＜0.05 ＜0.01 |
Discuss
Chronic pelvic inflammatory disease is the comparatively common delay of gynecological, intractable, refractory disease, does not still have unified, standard, specific Therapeutic Method at present.The pelvic tissue of chronic pelvic inflammatory disease all has stagnation of QI-blood in various degree.The traditional Chinese medical science thinks that pelvic inflammation by the hot stasis of blood of cold-damp, accumulates among the born of the same parents, and QI-blood circulation is not smooth, and with the passing of time meridians are obstructed, stagnation of QI and blood may bring about pain, and the total principle of its treatment is a heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling.And modern medicine is thought, activating blood and removing stasis drug has in various degree blood vessel dilating, blood viscosity lowering and capillary permeability and improves blood circulation, reaches antiinflammatory and analgesic effect.Therefore, be one of important method with the treatment by Chinese herbs chronic pelvic inflammatory disease.Red astragalus root for removing blood stasis sheet energy blood circulation promoting and blood stasis dispelling, the effect that has microcirculation improvement, regulates organism metabolism and immunity by improving Abwehrkraft des Koepers, reaches the sterilization purpose.This group observation of curative effect is the result show, adopt treatment by Chinese herbs 1 course of treatment after, total effective rate is 80.36%, every clinical symptoms improvement rate reaches more than 82.14%; After treating for 2,3 courses of treatment, total effective rate is respectively 90.48% and 96.67%, relatively has significant difference with matched group, and promptly Chinese drug-treated group all is higher than Western medicine group (P＜0.05 or＜0.01), illustrate and adopt the method for Chinese medicine for oral administration that chronic pelvic inflammatory disease is had curative effect preferably, be worth applying clinically.
The specific embodiment
Embodiment one, a kind of red astragalus root for removing blood stasis slow releasing tablet of the present invention and preparation method, its prescription is made up of 20 following flavor medicines:
Radix Astragali 150g Radix Salviae Miltiorrhizae 150g Radix Codonopsis 75g Rhizoma Dioscoreae 75g
Rhizoma Smilacis Glabrae 100g Radix Angelicae Sinensis 75g Caulis Spatholobi 150g Semen Euryales 75g
Herba Houttuyniae 150g rhizoma sparganic 15g Rhizoma Curcumae 45g Scorpio 75g
Herba Patriniae 150g Cortex Cinnamomi 15g Rhizoma Atractylodis Macrocephalae 45g Rhizoma Zingiberis Preparatum 22.5g
Eupolyphaga Seu Steleophaga 75g Rhizoma Corydalis 75g toosendan fruit 45g Radix Sophorae Flavescentis 75g adds appropriate amount of auxiliary materials and makes 1000 altogether.
More than 20 the flavor, Scorpio, Eupolyphaga Seu Steleophaga, Rhizoma Corydalis, Rhizoma Curcumae are ground into fine powder; Ten Six-element medicines such as all the other Radix Salviae Miltiorrhizaes decoct with water three times, add 10 times of water gagings for the first time, and second and third time adds 8 times of water gagings respectively, and decocting time was followed successively by 3 hours, 2 hours, 1 hour, filter, and merging filtrate, being concentrated into relative density is the clear paste of 1.29 (60 ℃); With fine powder mixing such as above-mentioned Scorpio, drying under reduced pressure is ground into fine powder, adds an amount of hydrophilic gel matrix tablet HPMC (K4M) mixing, makes soft material with 80% ethanol as wetting agent, granulation, drying, granulate, tabletting, coating, quality inspection, and packing is promptly.
Embodiment two, a kind of red astragalus root for removing blood stasis slow releasing tablet of the present invention and two kinds of preparation methoies comprise the steps:
1.1 the prescription of red astragalus root for removing blood stasis slow releasing tablet is formed
Radix Astragali 150g Radix Salviae Miltiorrhizae 150g Radix Codonopsis 75g Rhizoma Dioscoreae 75g
Rhizoma Smilacis Glabrae 100g Radix Angelicae Sinensis 75g Caulis Spatholobi 150g Semen Euryales 75g
Herba Houttuyniae 150g rhizoma sparganic 15g Rhizoma Curcumae 45g Scorpio 75g
Herba Patriniae 150g Cortex Cinnamomi 15g Rhizoma Atractylodis Macrocephalae 45g Rhizoma Zingiberis Preparatum 22.5g
Eupolyphaga Seu Steleophaga 75g Rhizoma Corydalis 75g toosendan fruit 45g Radix Sophorae Flavescentis 75g
Add appropriate amount of auxiliary materials and make 1000 altogether.
1.2 the preparation technology of red astragalus root for removing blood stasis slow releasing tablet
Technology one, above 20 flavors, Scorpio, Eupolyphaga Seu Steleophaga, Rhizoma Corydalis, Rhizoma Curcumae are ground into fine powder; Ten Six-element medicines such as all the other Radix Salviae Miltiorrhizaes decoct with water three times, add 10 times of water gagings for the first time, and second and third time adds 8 times of water gagings respectively, and decocting time was followed successively by 3 hours, 2 hours, 1 hour, filter, and merging filtrate, being concentrated into relative density is the clear paste of 1.28 (60 ℃); With fine powder mixing such as above-mentioned Scorpio, drying under reduced pressure is ground into fine powder, adds carboxymethylstach sodium, starch, mixing, use 80% alcohol granulation, drying, granulate adds magnesium stearate, mixing is pressed into 1000, and the bag film-coat is promptly made 1000 red astragalus root for removing blood stasis slow releasing tablet.
20 flavor medicine one-hundred-percent inspections in technology two, the prescription are qualified standby, Scorpio, soil are suppressed worm, Rhizoma Corydalis, Rhizoma Curcumae and are dried to fine powder, remaining 16 flavor medicine decocts with water 2-4 time, each 1-4 hour, collecting decoction, filter, be concentrated into relative density and be fine powder mix homogeneously, dryings such as the clear paste of 1.20 (60 ℃) and above-mentioned Scorpio, be ground into fine powder, add an amount of hydrophilic gel matrix tablet HPMC (K4M) mixing, make soft material with 80% ethanol as wetting agent, granulation, drying, granulate, tabletting, coating, quality inspection, packing promptly gets 1000 red astragalus root for removing blood stasis slow releasing tablet.
1.3 by the technology gained is sheet
Being ground into fine powder in the technology was 100 purpose fine powders, was ground into coarse powder, decoction pieces in the technology for being ground into 15 orders.
The preparation of matrix sustained release tablet agent in the technology: the addition of hydrophilic gel matrix tablet HPMC is 70g, and specification should be more than 4000cPas.
Decocting boils or the condition of water steaming and decocting is in the technology; Amount of water is the amount of 10 times of the first time, and second is 8 times amount for the third time, decocts 3 times, and the time was followed successively by 3 hours, 2 hours, 1 hour.
The spray drying inlet temperature is 150～200 ℃ in the technology, and leaving air temp is 50～150 ℃, and best inlet temperature is 150～170 ℃, and the temperature of air-out is preferably 70～75 ℃, and the temperature of particle drying is controlled at 55 ± 5 ℃ in the technology, is preferably 62 ± 3 ℃.
Claims (10)
1, a kind of red astragalus root for removing blood stasis piece preparation method, it is characterized in that: 150 parts of the Radixs Astragali, 150 parts of Radix Salviae Miltiorrhizaes, 75 parts of Radix Codonopsis, 75 parts of Rhizoma Dioscoreaes, 100 parts of Rhizoma Smilacis Glabraes, 75 parts of Radix Angelicae Sinensis, 150 parts of Caulis Spatholobis, 75 parts of Semen Euryaless, 150 parts of Herba Houttuyniae, 15 parts of rhizoma sparganic, 150 parts of Herba Patriniae, 15 parts of Cortex Cinnamomis, 45 parts of the Rhizoma Atractylodis Macrocephalaes, 22.5 parts of Rhizoma Zingiberis Preparatums, 45 parts of toosendan fruits, 75 parts of Radix Sophorae Flavescentiss, 75 parts of Scorpios, 45 parts of Rhizoma Curcumae, 75 parts of Eupolyphaga Seu Steleophagas, 75 parts of Rhizoma Corydalis, back four Chinese medicine grinds, all the other ten Six-element medicines decoct with water and are condensed into extractum and grind the powder mix homogeneously with four Chinese medicine, dry, be ground into fine powder, add auxiliary materials and mixing again, granulate, dry, granulate, tabletting, coating, quality inspection, packing promptly.
2, according to the described red astragalus root for removing blood stasis piece preparation method of claim 1, it is characterized in that: ten Six-element medicines decoct with water three times, add for the first time 10 times of water gagings, second and third time adds 8 times of water gagings respectively, decocting time was followed successively by 3 hours, 2 hours, 1 hour, filter, merging filtrate, being concentrated into relative density is the clear paste of 1.28～1.30 (60 ℃); With fine powder mixing such as above-mentioned Scorpio, drying under reduced pressure is ground into fine powder, adds carboxymethylstach sodium, starch, and mixing use 80% alcohol granulation, drying, and granulate, the adding magnesium stearate, mixing, tabletting, bag film-coat, quality inspection are packed promptly.
3, according to the described red astragalus root for removing blood stasis piece preparation method of claim 1, it is characterized in that: ten Six-element medicines decoct with water 2-4 time, each 1-4 hour, collecting decoction filters, and is concentrated into relative density and is fine powder mix homogeneously, dryings such as the clear paste of 1.05-1.35 (60 ℃) and above-mentioned Scorpio, is ground into fine powder, add an amount of hydrophilic gel matrix tablet HPMC (K4M) mixing, make soft material with 80% ethanol as wetting agent, granulation, drying, granulate, tabletting, coating, quality inspection, packing is promptly.
4, according to claim 1 or 2 or 3 described red astragalus root for removing blood stasis piece preparation methods, it is characterized in that: the adjuvant of red astragalus root for removing blood stasis sheet can be that any or more than one kinds mixing in HPMC, carboxymethyl starch sodium, starch, hypromellose, microcrystalline Cellulose, Pulvis Talci, magnesium stearate, the coating powder etc. is used.
5, according to claim 1 or 2 or 3 described red astragalus root for removing blood stasis piece preparation methods, it is characterized in that: the addition of the preparation of slow releasing tablet: HPMC is 50～90g in the technology, and specification should be more than 4000cPas; Optimal addn is 70～80g, and specification is K4M.
6, it is characterized in that according to claim 1 or 2 or 3 described red astragalus root for removing blood stasis sheets and preparation method: the technology crushing fine powder was 80～120 purpose fine powders, was ground into coarse powder in the technology, and decoction pieces was for being ground into 10～20 purpose coarse powder, and decoction pieces is 10～20 order coarse powder.
7, according to claim 1 or 2 or 3 described red astragalus root for removing blood stasis piece preparation methods, it is characterized in that: decocting boils or the condition of water steaming and decocting is in the technology; Amount of water is the amount of 10 times of the first time, and second is 8 times amount for the third time, decocts 3 times, and the time was followed successively by 3 hours, 2 hours, 1 hour.
8, according to claim 1 or 2 or 3 described red astragalus root for removing blood stasis piece preparation methods, it is characterized in that: the density that is condensed into clear paste in the technology is that the best relative density of 1.20～1.35 (60 ℃) is 1.28～1.30 (60 ℃).
9, it is characterized in that according to described red astragalus root for removing blood stasis sheet of claim 1 and preparation method: the spray drying inlet temperature is 150～200 ℃ in the technology, leaving air temp is 50～150 ℃, best inlet temperature is 150～170 ℃, the optimum temperature of air-out is 70～75 ℃, and the temperature of particle drying is controlled at 55 ± 5 ℃ and is preferably 62 ℃ in the technology.
10, a kind of red astragalus root for removing blood stasis sheet is characterized in that: be by 150 parts of the Radixs Astragali, 150 parts of Radix Salviae Miltiorrhizaes, 75 parts of Radix Codonopsis, 75 parts of Rhizoma Dioscoreaes, 100 parts of Rhizoma Smilacis Glabraes, 75 parts of Radix Angelicae Sinensis, 150 parts of Caulis Spatholobis, 75 parts of Semen Euryaless, 150 parts of Herba Houttuyniae, 15 parts of rhizoma sparganic, 150 parts of Herba Patriniae, 15 parts of Cortex Cinnamomis, 45 parts of the Rhizoma Atractylodis Macrocephalaes, 22.5 parts of Rhizoma Zingiberis Preparatums, 45 parts of toosendan fruits, 75 parts of Radix Sophorae Flavescentiss, 75 parts of Scorpios, 45 parts of Rhizoma Curcumae, 75 parts of Eupolyphaga Seu Steleophagas, 75 parts of flake drugs of making of Rhizoma Corydalis.
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| CN103041310A (en) * | 2012-12-25 | 2013-04-17 | 吴宗丽 | Traditional Chinese medicine enema for treating chronic pelvic inflammatory disease |
| CN103251044A (en) * | 2012-03-23 | 2013-08-21 | 山东德圣医药科技有限公司 | Health-care food used for relieving physical fatigue |
| CN103638483A (en) * | 2013-11-21 | 2014-03-19 | 吉林龙鑫药业有限公司 | Blood stasis removing capsule containing Salvia miltiorrhiza and Radix Astragali, and preparation method thereof |
| CN104116801A (en) * | 2013-07-15 | 2014-10-29 | 成都科创佳思科技有限公司 | Patent Chinese medicine for treating pelvic congestion syndrome |
| CN104147211A (en) * | 2014-08-29 | 2014-11-19 | 吕铝淼 | Medicine for treating gynecologic inflammation |
| CN108578668A (en) * | 2018-07-25 | 2018-09-28 | 江苏黄河药业股份有限公司 | A kind of pellet astragalus root for removing blood stasis piece and preparation method thereof |
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| CN110960653A (en) * | 2016-09-10 | 2020-04-07 | 四川金堂海纳生物医药技术研究所 | Traditional Chinese medicine composition for treating chronic pelvic inflammation caused by qi deficiency and blood stasis |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103251044A (en) * | 2012-03-23 | 2013-08-21 | 山东德圣医药科技有限公司 | Health-care food used for relieving physical fatigue |
| CN103041310A (en) * | 2012-12-25 | 2013-04-17 | 吴宗丽 | Traditional Chinese medicine enema for treating chronic pelvic inflammatory disease |
| CN104116801A (en) * | 2013-07-15 | 2014-10-29 | 成都科创佳思科技有限公司 | Patent Chinese medicine for treating pelvic congestion syndrome |
| CN103638483A (en) * | 2013-11-21 | 2014-03-19 | 吉林龙鑫药业有限公司 | Blood stasis removing capsule containing Salvia miltiorrhiza and Radix Astragali, and preparation method thereof |
| CN104147211A (en) * | 2014-08-29 | 2014-11-19 | 吕铝淼 | Medicine for treating gynecologic inflammation |
| CN110960653A (en) * | 2016-09-10 | 2020-04-07 | 四川金堂海纳生物医药技术研究所 | Traditional Chinese medicine composition for treating chronic pelvic inflammation caused by qi deficiency and blood stasis |
| CN108619471A (en) * | 2018-06-21 | 2018-10-09 | 吉林龙鑫药业有限公司 | A kind of vacuum belt drier and its application |
| CN108619471B (en) * | 2018-06-21 | 2021-07-20 | 吉林龙鑫药业有限公司 | Danhuang stasis removing capsule and preparation process thereof |
| CN108578668A (en) * | 2018-07-25 | 2018-09-28 | 江苏黄河药业股份有限公司 | A kind of pellet astragalus root for removing blood stasis piece and preparation method thereof |
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