CN102363020B - Chinese medicinal composition for treating proliferation of mammary gland - Google Patents
Chinese medicinal composition for treating proliferation of mammary gland Download PDFInfo
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Abstract
The invention belongs to the technical field of Chinese medicines and particularly relates to a Chinese medicinal composition for treating proliferation of mammary gland. The Chinese medicinal composition is characterized by consisting of the following Chinese herbal medicines: pangolin, indian iphigenia bulb, zedoary, philippine violet herb, prunella vulgaris, snakegourd fruit, Chinese honeylocust spine, bupleurum chinense, myrrh, tangerine seed, oldenlandia diffusa, pollen, epimedium herb, burdock seed, tangerine peel, pericarpium citri reticulatae viride, honeysuckle flower, weeping forsythia, scutellaria baicalensis, szechwan chinaberry fruit, scrophularia, ligusticum wallichii, red paeony root, stiff silkworm, cyperus rotundus, lumbricus, liquorice, gardenia, rhizoma corydalis, fritillary, silktree albizzia bark, pinellia ternata and frankincense. Through clinical observation on the application of the medicine, the Chinese medicine has the advantages of quick response, stable curative effect, short treatment course, high cure rate, and small effect.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine composition for the treatment of cyclomastopathy.
Background technology
Cyclomastopathy is the modal cystic hyperplasia of breast of women.This disease is more common in 20～45 years old middle-aged women, accounts for the women of child-bearing age's about 40%, accounts for about 75% of whole mastopathy.Because this disease is in progressive continuously evolution process, what canceration took place accounts for 2%～3%, the serious physical and mental health that is endangering numerous women.In recent years, along with the variation of living environment, the cyclomastopathy sickness rate rises year by year, and the trend rejuvenation, and corresponding breast cancer incidence also becomes to increasing.For this reason, many medical research personnel utilize diverse ways that the pathogenesis of cyclomastopathy is carried out exploratory development from different angles, though obtained certain achievement, from clinical therapeutic efficacy, still undesirable.Because western medicine exists easily recurrence and the big drawback of side effect, therefore many for this disease based on treatment by Chinese herbs, yet at present conventional Chinese medicine have mostly that treatment cycle is long, curative effect is not obvious, problem.
Summary of the invention
The objective of the invention is to overcome the problems referred to above that existing treatment by Chinese herbs cyclomastopathy exists, a kind of evident in efficacy, Chinese medicine composition that oral administration is treated cyclomastopathy easily is provided.
Purpose of the present invention is achieved through the following technical solutions:
A kind of Chinese medicine composition for the treatment of cyclomastopathy is characterized in that: be made up of following medicaments in part by weight material combination: Squama Manis 6-14g, Pseudobulbus Cremastrae Seu Pleiones 6-12g, Radix Curcumae 6-14g, Herba Violae 6-14g, Spica Prunellae 4-8g, Fructus Trichosanthis 12-18g, Spina Gleditsiae 6-12g, Radix Bupleuri 10-14g, Myrrha 4-8g, Semen Citri Reticulatae 4-8g, Herba Hedyotidis Diffusae 12-18g, pollen 614g, Herba Epimedii 4-8g, Fructus Arctii seed 4-8g, Pericarpium Citri Reticulatae 4-8g, Pericarpium Citri Reticulatae Viride 4-8g, Flos Lonicerae 12-18g, Fructus Forsythiae 12-18g, Radix Scutellariae 4--8g, Fructus Toosendan 6-12g, Radix Scrophulariae 10-14g, Rhizoma Chuanxiong 6-12g, Radix Paeoniae Rubra 6-12g, Bombyx Batryticatus 6-14g, Rhizoma Cyperi 4-8g, Pheretima 6-12g, Radix Glycyrrhizae 4-8g, Fructus Gardeniae 4-8g, Rhizoma Corydalis 6-12g, Bulbus Fritillariae Thunbergii 4-8g, Cortex Albiziae 10-14g, Rhizoma Pinelliae 10-14g, Olibanum 4-8g.
The said medicine raw material adds conventional adjuvant after mixing pulverizing by described weight portion, can be made into any peroral dosage form commonly used, as pill, tablet, oral liquid, capsule etc., all within protection scope of the present invention.
Medicine of the present invention, medication is reasonable, the compatibility science.Squama Manis, Pseudobulbus Cremastrae Seu Pleiones, Myrrha, Radix Curcumae, Spina Gleditsiae, Rhizoma Corydalis in the side: have that blood circulation promoting and blood stasis dispelling, dissipating phlegm and resolving masses, logical blood are active, the effect of reducing swelling and alleviating pain; Radix Bupleuri, Spica Prunellae, Pericarpium Citri Reticulatae Viride, Semen Citri Reticulatae have the effect of depressed liver-energy dispersing and QI regulating, eleminating phlegm and freeing channels; Herba Violae, Herba Hedyotidis Diffusae, Fructus Arctii seed, Flos Lonicerae, Fructus Forsythiae, Radix Scutellariae, Radix Scrophulariae, Radix Paeoniae Rubra, Bombyx Batryticatus, Pheretima, Radix Glycyrrhizae, Fructus Gardeniae: heat-clearing and toxic substances removing; Pericarpium Citri Reticulatae, the Rhizoma Pinelliae drying dampness to eliminate phlegm; Fructus Toosendan, Rhizoma Chuanxiong, Rhizoma Cyperi, Olibanum: invigorate blood circulation promoting the circulation of QI to relieve pain; Bulbus Fritillariae Thunbergii, relieving cough and resolving phlegm, heat clearing away eliminating stagnation; Cortex Albiziae, resolving depression and blood, mind calming, subduing inflammation; Herba Epimedii, pollen, reinforcing the kidney and supporting YANG, Chong and Ren Meridians regulating.Full side's compatibility has the effect of dispersing the stagnated live-QI to relieve the stagnation of QI, activating QI to eliminate phlegm, promoting blood circulation to remove obstruction in the collateral, dispersing swelling and dissipating binds, and its beneficial effect is: treatment is comprehensive, comprehensively regulating, prove that by clinical observation its curative effect is rapid, stable to medicine of the present invention, short treating period, the cure rate height, side effect is little.
The clinical observation of Drug therapy cyclomastopathy of the present invention
In order to verify the curative effect of medicine of the present invention, set up special clinical observation research treatment group in December, 2002 in Lingtai County, Pingliang, Gansu Province Huangfu Mi institute of traditional Chinese medicine, use the capsule of medication preparation of the present invention that 200 routine cyclomastopathy patients are carried out the systematic study treatment in by the end of July, 2011 to, its curative effect data is as follows.
1, physical data
260 routine cyclomastopathy patients make a definite diagnosis by clinical symptoms and sign, color ultrasound.Adopt parallel control grouping at random.
1.1 the physical data of treatment group
200 examples are organized in treatment, and the oldest 52 years old, minimum 23 years old, 37.5 years old mean age; 23～30 years old 38 examples, 31～40 years old 105 example, 57 examples more than 41 years old; The shortest person of the course of disease 2 months, elder 17 years, average 8.6 years; 1～5 month 32 example, half a year～1 year 61 examples, 2～3 years 66 examples; 4～6 years 26 examples, 7～9 years 4 examples account for 11 examples more than 10 years.Except that 63 examples were not done the systematic treating, all the other 137 examples were all done systematic treating, and wherein Chinese medicine is that main treatment accounts for 70%, and combination therapy of Chinese and western accounts for 30%.
1.2 matched group physical data
Matched group 60 examples, the oldest person 49 years old, reckling 25 years old, 36.8 years old mean age; 25～30 years old 12 examples, 31～40 years old 31 example, 17 examples more than 41 years old; The shortest person of the course of disease 2 months, elder 16 years, average 8 years; 1～5 month 9 example, half a year～1 year 18 examples, 2～3 years 20 examples; 4～6 years 8 examples, 7～9 years 2 examples account for 3 examples more than 10 years, and except that 19 examples were not done the systematic treating, all the other 41 examples were all done systematic treating, were that main treatment accounts for 70% with Chinese medicine wherein, and combination therapy of Chinese and western accounts for 30%.Two groups of no significant differences in age, morbidity season, occupation and excessive drinking hobby have comparability.
The I 1.3 treatment group and matched group inflammation kind and age segmentation relation table are seen attached list is with the course of disease length relation table II that sees attached list.
Subordinate list I and age segmentation concern statistical table
Subordinate list II and course of disease length concern statistical table
2, diagnostic criteria and traditional Chinese medical science typing
2.1 diagnostic criteria: single or multiple cakings appear in the one or both sides breast, most with the periodicity mastalgia, and many and emotion and menstrual cycle have obvious relation, general preceding 1 day left and right sides sx of menstrual onset, back caking and the pain of passing through obviously alleviates, and continuous 3 months can not spontaneous remission.Body is looked into: can touch the single or multiple irregular cakings that differ in size in the breast, matter is tough, multidigit in outside go up quadrant, tuberosity and surrounding tissue do not have adhesion, can be pushed, and have slight tenderness, the axillary lymph knot not quite.Auxiliary detection: utilize molybdenum target X line or xerography, color ultrasound, thermal image figure etc. to make a definite diagnosis, get rid of other good, malignant galactophore diseases such as breast carcinoma, mammary gland fibroma.
2.2 traditional Chinese medical science typing
2.2.1 stagnation of QI due to depression of the liver: be more common between twenty and fifty women.Lump in breast is relevant with susceptible to anger, expands with breast uncomfortable in chest, kind strongly fragrant irritability, insomnia and dreamful sleep, vexed bitter taste, tongue fur jaundice, stringy and rolling pulse.
2.2.2 Chong and Ren channel disorder: be more common in middle-aged women, increase the weight of before the lump in breast menstruation, through after alleviate, weak with lumbago, tired, menstruation is successively lacked of proper care, the light or amenorrhea of the few color of amount, tongue fur HUANGBAI(sic), deep-thready pulse.
3, Therapeutic Method:
3.1 the treatment group is taken the capsule of medication preparation of the present invention: 0.4g/ grain, 5/time, 3 times/day, warm water delivery service.
3.2 matched group take RUPIXIAO (new peace street, Huan Ren town, Manchu Autonomous County of Juanren, Liaoning Province produces the accurate word of traditional Chinese medicines: Z21021823) 5 slices/time, 3 times/d, warm water delivery service.
All taking medicine 30 days for two groups was 1 course of treatment, judged curative effect after 1 course of treatment.
4, criterion of therapeutical effect
Draft with reference to " traditional Chinese medical science disease diagnosis criterion of therapeutical effect ".Cure: lump in breast and pain disappear, and do not recur in three months after the drug withdrawal.Produce effects: the lump maximum gauge dwindles 1/2, and mastalgia disappears.Take a turn for the better: (1) lump in breast maximum gauge dwindles less than 1/2, and mastalgia alleviates.(2) lump dwindles more than 1/2, and mastalgia disappears.Invalid: (1) lump does not dwindle, or increases hardening person repeatedly; (2) simple mastalgia is alleviated, and lump does not dwindle.
5, therapeutic outcome
5.1 relatively treatment group of two groups of curative effects is totally 200 examples, total effective rate 94% is compared with 60 routine matched group curative effects, P＜0.01, and difference has the meaning of highly significant, sees Table III
Subordinate list III: treatment group and matched group total effects statistical table
Through X
2Check, P＜0.01, prompting treatment group curative effect obviously is better than matched group
5.2 Chinese medical discrimination typing and therapeutic effect relationship see Table IV
Table IV Chinese medical discrimination typing and therapeutic effect relationship (n)
6, conclusion:
Treat 200 routine cyclomastopathy patients in by the end of July, 2011 by, cure 84 examples (42%), produce effects 38 examples (19%), 66 examples that take a turn for the better (33%), invalid (containing deterioration) 2 examples (6%), total effective rate is apparently higher than matched group.
The specific embodiment
Embodiment 1
Take by weighing following medicaments in part by weight raw material: Squama Manis 7g, Pseudobulbus Cremastrae Seu Pleiones 7g, Radix Curcumae 7g, Herba Violae 8g, Spica Prunellae 5g, Fructus Trichosanthis 14g, Spina Gleditsiae 10g, Radix Bupleuri 10g, Myrrha 5g, Semen Citri Reticulatae 5g, Herba Hedyotidis Diffusae 15g, pollen 10g, Herba Epimedii 6g, Fructus Arctii seed 4g, Pericarpium Citri Reticulatae 4g, Pericarpium Citri Reticulatae Viride 4g, Flos Lonicerae 12g, Fructus Forsythiae 12g, Radix Scutellariae 4g, Fructus Toosendan 8g, Radix Scrophulariae 10g, Rhizoma Chuanxiong 6g, Radix Paeoniae Rubra 6g, Bombyx Batryticatus 6g, Rhizoma Cyperi 8g, Pheretima 6g, Radix Glycyrrhizae 8g, Fructus Gardeniae 4g, Rhizoma Corydalis 8g, Bulbus Fritillariae Thunbergii 8g, Cortex Albiziae 12g, Rhizoma Pinelliae 12g, Olibanum 8g, with the said medicine raw material pulverizing, sieve, sterilization, fill makes capsule, 0.4g gram/grain.
Chinese medicine composition of the present invention when taking, each 5, every day three times, warm water delivery service.The period in a medicine fasting is pungent, the product of stimulation reach the irritant medicine of gastrointestinal.
Embodiment 2
Take by weighing following medicaments in part by weight raw material: Squama Manis 10g, Pseudobulbus Cremastrae Seu Pleiones 10g, Radix Curcumae 10g, Herba Violae 8g, Spica Prunellae 4g, Fructus Trichosanthis 12g, Spina Gleditsiae 6g, Radix Bupleuri 10g, Myrrha 6g, Semen Citri Reticulatae 6g, Herba Hedyotidis Diffusae 12g, pollen 12g, Herba Epimedii 8g, Fructus Arctii seed 6g, Pericarpium Citri Reticulatae 8g, Pericarpium Citri Reticulatae Viride 6g, Flos Lonicerae 15g, Fructus Forsythiae 12g, Radix Scutellariae 6g, Fructus Toosendan 6g, Radix Scrophulariae 12g, Rhizoma Chuanxiong 8g, Radix Paeoniae Rubra 8g, Bombyx Batryticatus 8g, Rhizoma Cyperi 6g, Pheretima 6g, Radix Glycyrrhizae 6g, Fructus Gardeniae 6g, Rhizoma Corydalis 12g, Bulbus Fritillariae Thunbergii 6g, Cortex Albiziae 10g, Rhizoma Pinelliae 10g, Olibanum 6g, with the said medicine raw material pulverizing, sieve, sterilization, fill makes capsule, 0.4g gram/grain.Instructions of taking is identical with embodiment 1.
Claims (2)
1. a Chinese medicine composition for the treatment of cyclomastopathy is characterized in that being made up of following medicaments in part by weight material combination: Squama Manis 6-14g, Pseudobulbus Cremastrae Seu Pleiones 6-12g, Radix Curcumae 6-14g, Herba Violae 6-14g, Spica Prunellae 4-8g, Fructus Trichosanthis 12-18g, Spina Gleditsiae 6-12g, Radix Bupleuri 10-14g, Myrrha 4-8g, Semen Citri Reticulatae 4-8g, Herba Hedyotidis Diffusae 12-18g, pollen 6-14g, Herba Epimedii 4-8g, Fructus Arctii seed 4-8g, Pericarpium Citri Reticulatae 4-8g, Pericarpium Citri Reticulatae Viride 4-8g, Flos Lonicerae 12-18g, Fructus Forsythiae 12-18g, Radix Scutellariae 4-8g, Fructus Toosendan 6-12g, Radix Scrophulariae 10-14g, Rhizoma Chuanxiong 6-12g, Radix Paeoniae Rubra 6-12g, Bombyx Batryticatus 6-14g, Rhizoma Cyperi 4-8g, Pheretima 6-12g, Radix Glycyrrhizae 4-8g, Fructus Gardeniae 4-8g, Rhizoma Corydalis 6-12g, Bulbus Fritillariae Thunbergii 4-8g, Cortex Albiziae 10-14g, Rhizoma Pinelliae 10-14g, Olibanum 4-8g.
2. a kind of Chinese medicine composition for the treatment of cyclomastopathy according to claim 1 is characterized in that being made up of following medicaments in part by weight raw material: Squama Manis 7g, Pseudobulbus Cremastrae Seu Pleiones 7g, Radix Curcumae 7g, Herba Violae 8g, Spica Prunellae 5g, Fructus Trichosanthis 14g, Spina Gleditsiae 10g, Radix Bupleuri 10g, Myrrha 5g, Semen Citri Reticulatae 5g, Herba Hedyotidis Diffusae 15g, pollen 10g, Herba Epimedii 6g, Fructus Arctii seed 4g, Pericarpium Citri Reticulatae 4g, Pericarpium Citri Reticulatae Viride 4g, Flos Lonicerae 12g, Fructus Forsythiae 12g, Radix Scutellariae 4g, Fructus Toosendan 8g, Radix Scrophulariae 10g, Rhizoma Chuanxiong 6g, Radix Paeoniae Rubra 6g, Bombyx Batryticatus 6g, Rhizoma Cyperi 8g, Pheretima 6g, Radix Glycyrrhizae 8g, Fructus Gardeniae 4g, Rhizoma Corydalis 8g, Bulbus Fritillariae Thunbergii 8g, Cortex Albiziae 12g, Rhizoma Pinelliae 12g, Olibanum 8g.
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| CN103536745B (en) * | 2012-07-12 | 2016-02-24 | 马建民 | A kind of Chinese kmedicine bolus for the treatment of cyclomastopathy |
| CN103156985B (en) * | 2013-03-16 | 2014-05-21 | 武玉丽 | Traditional Chinese medicine composition for treating cyclomastopathy |
| CN103479863B (en) * | 2013-10-22 | 2015-05-06 | 刘保彦 | Traditional Chinese medicine composition for treating breast cystic hyperplasia |
| CN103623226B (en) * | 2013-11-28 | 2015-10-07 | 王志 | A kind of Chinese medicine composition for the treatment of cyclomastopathy |
| CN104189428A (en) * | 2014-09-09 | 2014-12-10 | 王艳丽 | Traditional Chinese medicinal preparation for treating proliferation of mammary glands |
| CN106075026A (en) * | 2016-07-08 | 2016-11-09 | 丁鸿磊 | A kind of Chinese medicine treating cyclomastopathy and preparation method thereof |
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| CN101708300A (en) * | 2009-12-17 | 2010-05-19 | 徐亚琴 | Medicinal composition for treating scrofula, hyperplasia of mammary glands and benign lymphadenoma |
| CN101966320A (en) * | 2010-07-13 | 2011-02-09 | 泰一和浦（北京）中医药研究院有限公司 | Chinese medicinal composition for treating proliferation of mammary gland and preparation method thereof |
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