A kind of Chinese medicine that is used to treat noxious dampness type influenza and preparation method thereof
Technical field
The invention belongs to the field of Chinese medicines, particularly a kind of Chinese medicine that is used to treat noxious dampness type influenza and preparation method thereof.
Background technology
Influenza is grippal abbreviation; It is a kind of acute respiratory infectious disease that causes by influenza virus; Its sickness rate occupies the first place of infectious disease; Has extremely strong infectiousness; Be one of main public health problem, belong to the category of the traditional Chinese medical science " influenza ", " fever caused by exogenous pathogens ", " epidemic febrile disease ", " epidemic disease ".Main clinic symptoms is heating, pharyngalgia, watery nasal discharge, nasal obstruction, cough, cough up phlegm, headache, systemic pain, weak; Vomiting or diarrhoea appear in some cases.Hyperpyrexia is that the serious symptom influenza is run initially and one of topmost symptom, how above 39 ℃.Put down in writing as far back as the classical Chinese medicine Huangdi's Internal Classics: " five types of pestilence extremely, all infection is prone to, and does not have and asks size, condition of illness is similar ".It is according to patient's clinical sign and determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs that the traditional Chinese medical science is prevented and treated pestilence, and therefore, no matter whether virus variation, and traditional Chinese medical science pestilence theory and practice is the effective way of treatment influenza.In addition, the influenza pathogenic factor mainly is six climate exopathogens and epidemic miasma, damp and hot pathogen be exterior syndrome commonly encountered diseases because of, and changeful, syndrome is complicated.The two combined pathogens has more increased the complexity and the difficulty of treatment of influenza.Damp invasion and attack human body, the retardance mechanism of qi, the meridians of being detained, even fill the air three warmers, thus common general malaise, heaviness of the head as if it were tightly bandaged, and damp normal with other pathogenic factor mutually because of disease.Clinically, the damp-heat disease person of laying particular stress on often has the card of few positive three warmers concurrently, shows as alternative chill and fever, fullness in the chest abdominal distention, dark coloured urine, greasy fur on tongue etc.
Up to now, vaccine is still the popular major measure of flu-prevention, but grows and viral variability from producing life cycle, so the Western medicine antiviral drugs is the main selection of current prevention and control flu outbreak.Many to the treatment of influenza with antiviral, antibiotic and glucocorticoid treatment.Because the variability of influenza virus, said medicine can not fundamentally solve the problem of influenza.As for the serious symptom influenza; Simple glucocorticoid treatment can not prevent the generation of viral pneumonia; Long-term heavy dose of glucocorticoid that uses also might cause opportunistic infection and other side effect, increases the clinical death rate, and duplicating of virus can be further induced in the application of glucocorticoid simultaneously.Therefore, research and develop a kind of low toxicity efficiently, safely, have no drug resistance or low drug resistance antiviral drugs with prevention and control influenza, avoid light disease to transform and to receive extensive attention to serious symptom, danger disease.
The compound of Chinese medicine influenza has experience in several thousand, has the virus replication of inhibition, stops pathological changes caused by virus, regulates immunologic function, improves comprehensive effect such as pulmonary circulation and antalgic and inflammation relieving.The Chinese medicine early treatment can stop disease progression to serious symptom, shortens the course of disease simultaneously, and does not have obvious adverse reaction.Chinese medicine control the influenza curative effect certainly, safety, reduce persister and produce.Therefore, Chinese medicine comprises noxious dampness type influenza preventing and treating aspect the influenza, has special advantages and vast potential for future development.Treatment to noxious dampness type influenza is valued for determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs, is main with damp eliminating how, making wetly to dispel that then heat is lonely, should declare last, in suitable dry, infra should profit, the employing suffering is opened, hardship is let out, virtue is declared, lightly ooze and execute.Eliminating dampness method uses very extensive in epidemic febrile disease, gently a surname's agent, and diaphoresis lung qi dispersing, and the article of removing dampness by means of aromatics have embodied the lung is concerned with QI of the whole body, and lung qiization then spleen is wet from changing, and is not used to treat noxious dampness type influenza but still there is effective targetedly Chinese medicine compound at present.
Summary of the invention
In order to solve the weak point that exists in the above-mentioned prior art, primary and foremost purpose of the present invention is to provide a kind of Chinese medicine that is used to treat noxious dampness type influenza.
A further object of the present invention is to provide the above-mentioned preparation method of Chinese medicine that is used to treat noxious dampness type influenza.
The object of the invention is realized through following technical proposals: a kind of Chinese medicine that is used to treat noxious dampness type influenza, and this Chinese medicine is prepared from the following raw material of Chinese medicine of meter by weight: 10~20 parts of Radix Ilicis Asprellaes, 10~20 parts of Folium Microcoris paniculataes; 5~15 parts of Herba Pogostemoniss; 5~15 parts of Rhizoma Osmundae, 5~15 parts of Folium vilicis Negundo, 10~20 parts of Flos Loniceraes; 10~20 parts of Fructus Forsythiaes; 3~9 parts of the Radixs Angelicae Dahuricae collapse 5~15 parts of jorumes, 5~15 parts of Folium Isatidiss; 10~20 parts of Rhizoma Phragmitiss, 3~9 parts of Flos Chrysanthemis.
In order to realize the present invention better, the said Chinese medicine that is used to treat noxious dampness type influenza is prepared from the following raw material of Chinese medicine of meter by weight: 15 parts of Radix Ilicis Asprellaes, 15 parts of Folium Microcoris paniculataes; 10 parts of Herba Pogostemoniss; 10 parts of Rhizoma Osmundae, 10 parts of Folium vilicis Negundo, 15 parts of Flos Loniceraes; 15 parts of Fructus Forsythiaes; 5 parts of the Radixs Angelicae Dahuricae collapse 10 parts of jorumes, 10 parts of Folium Isatidiss; 15 parts of Rhizoma Phragmitiss, 5 parts of Flos Chrysanthemis.
A kind of preparation method of Chinese medicine that is used to treat noxious dampness type influenza; This method may further comprise the steps: get 10~20 parts of Radix Ilicis Asprellaes; 10~20 parts of Folium Microcoris paniculataes; 5~15 parts of Herba Pogostemoniss; 5~15 parts of Rhizoma Osmundae, 5~15 parts of Folium vilicis Negundo, 10~20 parts of Flos Loniceraes; 10~20 parts of Fructus Forsythiaes; 3~9 parts of the Radixs Angelicae Dahuricae collapse 5~15 parts of jorumes, 5~15 parts of Folium Isatidiss; 3~9 parts of 10~20 parts of Rhizoma Phragmitiss and Flos Chrysanthemis; Mix back decocte with water twice, the medicine juice that takes out after twice decoction is merged, leave standstill 24~48h; Filter, obtaining relative density after filtrating concentrates is 1.30~1.35g/cm
3, temperature is 50~70 ℃ a thick paste; With the thick paste spray drying, obtain spray drying powder, further be crushed to 80~120 orders again, obtain being used to treat the Chinese medicine of noxious dampness type influenza.
In order to realize the present invention better; Said decocte with water is for twice that raw material of Chinese medicine is mixed 50~90 ℃ of hot water that the back adds 8~12 times of raw material of Chinese medicine gross masses; Soak 1~2h post-heating, the back timing of boiling decocts 1~2h; Filter then and take out medicine juice; 50~90 ℃ of hot water that add 8~12 times of raw material of Chinese medicine gross masses again, heating decocts, the back timing of boiling; Decoct 1~2h, refilter the taking-up medicine juice.
Said simmer down to concentrating under reduced pressure, condition be pressure-0.07~-0.09Mpa, 50~70 ℃ of temperature.
Said spray-dired condition is 160~180 ℃ of inlet temperature, 70~80 ℃ of leaving air temps.
The pharmacology curative effect of various raw material of Chinese medicine is following:
Radix Ilicis Asprellae: cold in nature, bitter in the mouth, sweet; Return lung, liver, large intestine channel; Clearing away heat and promoting production of body fluid, dissipating blood stasis, detoxifcation;
Folium Microcoris paniculatae: property is flat, lightly seasoned, little acid; Return liver, spleen, stomach warp; Clearing away heat-damp and promoting diuresis, spleen invigorating disappears stagnant, reduces phlegm jaundice eliminating;
Herba Pogostemonis: slightly warm in nature, acrid in the mouth; Return spleen, stomach, lung meridian; Removing dampness, preventing or arresting vomiting, expelling summer-heat;
Rhizoma Osmundae: cold nature, bitter in the mouth, suffering; Return liver, spleen channel; Heat-clearing and toxic substances removing, cooling blood for hemostasis, parasite killing;
Folium vilicis Negundo: warm in nature, acrid in the mouth, hardship; Return liver, spleen, lung meridian; Dispel the wind expectorant, circulation of qi promoting, pain relieving;
Flos Lonicerae: cold in nature, sweet in the mouth; Return lung, the heart, stomach warp; Heat-clearing and toxic substances removing, dispelling wind and heat pathogens;
Fructus Forsythiae: cold nature, bitter in the mouth; Return lung, the heart, small intestine meridian; Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, dispelling wind and heat pathogens;
The Radix Angelicae Dahuricae: warm in nature, acrid in the mouth; Return lung, stomach, large intestine channel; The cold expelling that induces sweat, wind-expelling pain-stopping, clearing the nasal passage, dampness leukorrhagia stopping, detumescence and apocenosis;
Collapse jorum: cold in nature, bitter in the mouth, suffering; Return the liver,spleen,kidney warp; Clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling;
Folium Isatidis: cold in nature, bitter in the mouth; GUIXIN, stomach warp; Heat-clearing and toxic substances removing, blood cooling and ecchymoses removing;
Rhizoma Phragmitis: cold in nature, sweet in the mouth; Attach to the lung and stomach meridians; Clearing away heat-fire, promoting the production of body fluid to quench thirst, relieving restlessness, preventing or arresting vomiting, diuresis;
Flos Chrysanthemi: cold nature, acrid in the mouth, sweet, bitter; Return lung, Liver Channel; Diffusing wind heat clearing away, suppressing the hyperactive liver makes eye bright.
Principle of the present invention is:
Chinese medicine of the present invention is caught these pathogenic main points of noxious dampness to noxious dampness type influenza, eliminating turbid pathogen with aromatics, and the detoxifcation dehumidifying is the function of spleen and stomach regulating up-down, makes the wet as to change of life, wetting that rise the back do not given birth to, and is the method for effecting a permanent cure.And be principle with the determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs, therapeutical effect is good clinically.Noxious dampness type influenza belongs to the traditional Chinese medical science " damp-warm diseases " category more; Heat is by humidogene often for damp and hot card, and the wet middle heat of giving birth to is during the heat place wets; The two wraps up in knot each other; Cannot bear to part, wet hot then deeplyer, heat is because of wet more vehement; Damp and hot gluing; In treatment,, make the wet then heat orphan that dispels, make the oriented favourable turn of healing of disease especially when being important business with the damp eliminating.Damp and hot heresy causes the taste abnormal ascending-descending of QI because of burnt taste in the resistance, and middle burnt obstruction of QI sees that stool is arranged is not well, the vexed abdominal distention person of gastral cavity, and treatment is many with eliminating turbid pathogen with aromatics; Epidemic febrile disease from the beginning of, go into from mouth and nose, evil defending branch, defend gas by strongly fragrant, folding mistake department controls the table that should suffering cools completely, heat-clearing and toxic substances removing.The change of disease approach of epidemic febrile disease is a warm pathogen tend to attack the upper orifices, attacking the lung first, the pathogen attacking the pericardium adversely, Flos Lonicerae, Fructus Forsythiae fragrant odour in the side; Can dispelling wind and heat pathogens, heat-clearing and toxic substances removing, it is turbid to ward off dirtyization again; Saturating loose defend the branch pathogenic factor in the exterior in, taken into account the characteristics that warm pathogenic factor is prone to pent up the foul gas of the many again folders of poison, use to be principal agent.Pathogenic warmth is hurted sb.'s feelings, and so many YIN-fluid being insufficient are with the sweet cold article of Rhizoma Phragmitis; Clearing away heat-fire, promoting the production of body fluid to quench thirst, the specially heat of lung heat clearing stomach; And can promote the production of body fluid, sweet in the mouth is arranged and not grow greasyly, promote the production of body fluid and do not love evil characteristics; To damp-warm diseases, thermogravimetric and dysuria person, suitable especially, at this moment; Treatment embodies outcome and disappears to walk to let out, and a surname's gasification is wet emphatically, makes mechanism of qi a surname logical; Water channel is logical transfers that then damp is from removing, and residence has the Therapeutic Principle that epidemic febrile disease " is deposited the cloudy liquid of getting a point, just protected the life of getting a point " simultaneously.Damp and hot gluing is controlled with the clearing heat and expelling damp method, makes the wet then heat orphan that dispels, the gasification that recovers three warmers.Turbid with the removing dampness of Herba Pogostemonis virtue, preventing or arresting vomiting, the property of tepor does not help heat, helps removing dampness; Radix Angelicae Dahuricae removing dampness by means of aromatics is held concurrently to induce sweat; Rhizoma Osmundae, Folium Isatidis, collapse the jorum heat-clearing and toxic substances removing, dampness removing helps the principal agent detoxifcation to keep away pestilence, and Flos Chrysanthemi is sweet cold, and is light clear, evacuates wind-heat of liver channel; Folium vilicis Negundo, Folium Microcoris paniculatae, Radix Ilicis Asprellae clearing heat and expelling damp, circulation of qi promoting disappears stagnant, is guangdong herbal tea article commonly used, is the article commonly used of removing summer-heat damp-heat in upper-JIAO.We's medicament all is light clearly article, has embodied the epidemic febrile disease principle of medication of " controlling the part of the body cavity above the diaphragm housing the heart and lungs such as plumage, non-light erectile problem ".The present invention can full side's heat-clearing and toxic substances removing, and the turbid pestilence of keeping away of damp eliminatingization has prevention and therapeutical effect preferably to noxious dampness type influenza.
The present invention compared with prior art has following advantage and beneficial effect: the present invention is a foundation with the differentiation of tcm theory, adopts the mutual composition of prescription of above-mentioned active drug composition; Have heat-clearing and toxic substances removing, the effect of the clear pestilence of damp eliminating reaches the purpose of treating noxious dampness type influenza; And cost is low, and the medicine source is wide.The Chinese medicine medicated powder of above-mentioned method for preparing gained can be prepared into common Chinese medicine preparation, and like powder, tablet, granule, capsule etc., taking convenience is easy to accepted by the patient.
The specific embodiment
Below in conjunction with embodiment the present invention is described in further detail, but embodiment of the present invention is not limited thereto.
Embodiment 1
Take by weighing Radix Ilicis Asprellae 1500g, Folium Microcoris paniculatae 1500g, Herba Pogostemonis 1000g; Rhizoma Osmundae 1000g, Folium vilicis Negundo 1000g, Flos Lonicerae 1500g; Fructus Forsythiae 1500g, Radix Angelicae Dahuricae 500g collapses jorum 1000g; Folium Isatidis 1000g, Rhizoma Phragmitis 1500g and Flos Chrysanthemi 500g mix 90 ℃ of hot water that the back adds 8 times of raw material of Chinese medicine gross masses; Soak 1h, heating decocts, the back timing of boiling; Decoct 1.5h, filter and take out medicine juice, add 90 ℃ of hot water of 10 times of raw material of Chinese medicine gross masses again; Heating decocts, and the back timing of boiling decocts 2h; Filter and take out medicine juice; Merge the medicine juice that takes out, leave standstill 36h, filter; It is 1.30g/cm that filtrate decompression concentrates (pressure is-0.08Mpa that temperature is 70 ℃) to density
3, temperature is 60 ℃ a thick paste, with the thick paste spray drying (inlet temperature is 170 ℃, and leaving air temp is 70 ℃) that obtains, gets spray drying powder, is ground into 100 orders again, the Chinese medicine medicated powder of the noxious dampness type that promptly obtains medical treatment influenza.Contain the packing of 0.3g Chinese medicine medicated powder by every capsules.The patient is oral, every day 3 times, and each 3 capsules, 3 days is a course of treatment, takes 1~3 course of treatment, the state of an illness can take an evident turn for the better.
Embodiment 2
Take by weighing Radix Ilicis Asprellae 1000g, Folium Microcoris paniculatae 1000g, Herba Pogostemonis 500g; Rhizoma Osmundae 1500g, Folium vilicis Negundo 500g, Flos Lonicerae 1000g; Fructus Forsythiae 1000g, Radix Angelicae Dahuricae 300g collapses jorum 500g; Folium Isatidis 500g, Rhizoma Phragmitis 2000g and Flos Chrysanthemi 900g mix 50 ℃ of hot water that the back adds 10 times of raw material of Chinese medicine gross masses; Soak 1.5h, heating decocts, the back timing of boiling; Decoct 2h, filter and take out medicine juice, add 50 ℃ of hot water of 8 times of raw material of Chinese medicine gross masses again; Heating decocts, and the back timing of boiling decocts 1h; Filter and take out medicine juice; Merge the medicine juice that takes out, leave standstill 24h, filter; It is 1.32g/cm that filtrate decompression concentrates (pressure is-0.09Mpa that temperature is 50 ℃) to density
3, temperature is 50 ℃ a thick paste, with the thick paste spray drying (inlet temperature is 160 ℃, and leaving air temp is 80 ℃) that obtains, gets spray drying powder, is ground into 120 orders again, the Chinese medicine medicated powder of the noxious dampness type that promptly obtains medical treatment influenza.Contain the packing of 0.3g Chinese medicine medicated powder by every capsules.The patient is oral, every day 3 times, and each 3 capsules, 3 days is a course of treatment, takes 1~3 course of treatment, the state of an illness can take an evident turn for the better.
Embodiment 3
Take by weighing Radix Ilicis Asprellae 2000g, Folium Microcoris paniculatae 2000g, Herba Pogostemonis 1500g; Rhizoma Osmundae 500g, Folium vilicis Negundo 1500g, Flos Lonicerae 2000g; Fructus Forsythiae 2000g, Radix Angelicae Dahuricae 900g collapses jorum 1500g; Folium Isatidis 1500g, Rhizoma Phragmitis 1000g and Flos Chrysanthemi 300g mix 80 ℃ of hot water that the back adds 12 times of raw material of Chinese medicine gross masses; Soak 2h, heating decocts, the back timing of boiling; Decoct 1h, filter and take out medicine juice, add 80 ℃ of hot water of 12 times of raw material of Chinese medicine gross masses again; Heating decocts, and the back timing of boiling decocts 1.5h; Filter and take out medicine juice; Merge the medicine juice that takes out, leave standstill 32h, filter; It is 1.35g/cm that filtrate decompression concentrates (pressure is-0.07Mpa that temperature is 60 ℃) to density
3, temperature is 70 ℃ a thick paste, with the thick paste spray drying (inlet temperature is 180 ℃, and leaving air temp is 75 ℃) that obtains, gets spray drying powder, is ground into 80 orders again, the Chinese medicine medicated powder of the noxious dampness type that promptly obtains medical treatment influenza.Contain the packing of 0.3g Chinese medicine medicated powder by every capsules.The patient is oral, every day 3 times, and each 3 capsules, 3 days is a course of treatment, takes 1~3 course of treatment, the state of an illness can take an evident turn for the better.
Embodiment 4
Take the Chinese medicinal capsule of embodiment 1 preparation, clinical treatment noxious dampness type influenza 115 examples are out-patient treatment, wherein male 78 examples, women 37 examples; 4~58 years old age, 16.3 years old mean age, pharyngeal congestion 89 examples (77.4%) wherein, 98 examples of generating heat (85.2%); 96 examples of coughing (83.5%), pharyngalgia 105 examples (91.3%), 80 examples of having a headache (69.6%); Pulmonary's hello sound 41 examples (35.7%), expectoration 30 examples (26.1%), fear of cold 32 examples (27.8%).The patient is oral, every day 3 times, and each 3 capsules, 3 days is a course of treatment, general patient serve on 1~3 course of treatment.Diagnostic criteria: the diagnostic criteria according in " the influenza A H1N1 diagnosis scheme (2009 the 3rd edition) " of revision health ministry in October, 2009 is carried out.Criterion of therapeutical effect: recovery from illness: cough, expectoration and pulmonary's hello sound disappear, and body temperature is normal, the blood leukocytes counting that increases with (or) the neutrophilic granulocyte ratio recovers normal, C-XF shows that inflammation absorbs fully.Produce effects: cough obviously alleviates, and expectoration obviously reduces, and body temperature is normal, and pulmonary's hello sound obviously reduces, blood leukocytes counting with (or) the neutrophilic granulocyte ratio is normal, chest x-ray shows that inflammation is most of and absorbs.Effectively: cough alleviates, and expectoration reduces, and body temperature descends to some extent, and pulmonary's hello sound reduces, the blood leukocytes counting with (or) the neutrophilic granulocyte ratio descends, chest x-ray shows that inflammation absorbs to some extent.Invalid: symptom, sign and each item are checked equal no change, or have and increase the weight of.The clinical treatment result is: cure 90 examples, and produce effects 12 examples, effective 7 examples, invalid 6 examples, total effective rate is 94.8%.
Embodiment 5
Clinical treatment 4 routine disease analyses:
1, Zhao, the man, 16 years old, generate heat 39.5 ℃, cough, pharyngalgia 3 days, with expectoration, fear of cold, red tongue with thin and yellow fur, floating and rapid pulse.The patient takes the Chinese medicinal capsule of the embodiment of the invention 1, cures after 2 courses of treatment.
2, together certain, the woman, 23 years old, the heating fear of cold, 38.5 ℃ of body temperature, 2 days, watery nasal discharge, pharyngalgia, the red tongue tongue is white, floating and rapid pulse.The patient takes the Chinese medicinal capsule of the embodiment of the invention 2, cures after 1 course of treatment.
3, Chen, the man, 7 years old, heating pharyngalgia 2 days, 39.8 ℃ of body temperature, pulmonary's hello sound is obvious, headache, expectoration, the few yellow skin of amount, red tongue with thin fur is white, rapid pulse.Infant is taken the Chinese medicinal capsule of the embodiment of the invention 3, cures after 3 courses of treatment.
4, Wang, the man, 51 years old, fever and cough, 38.8 ℃ of body temperature, pulmonary's hello sound is obvious, expectoration, fear of cold, red tongue with thin fur is white, floating and rapid pulse.The patient takes the Chinese medicinal capsule of the embodiment of the invention 2, cures after 2 courses of treatment.
The foregoing description is a preferred implementation of the present invention; But embodiment of the present invention is not restricted to the described embodiments; Other any do not deviate from change, the modification done under spirit of the present invention and the principle, substitutes, combination, simplify; All should be the substitute mode of equivalence, be included within protection scope of the present invention.