CN102973728A - Chinese herbal medicine preparation for treating chicken infectious bronchitis - Google Patents

Chinese herbal medicine preparation for treating chicken infectious bronchitis Download PDF

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Publication number
CN102973728A
CN102973728A CN2012103842568A CN201210384256A CN102973728A CN 102973728 A CN102973728 A CN 102973728A CN 2012103842568 A CN2012103842568 A CN 2012103842568A CN 201210384256 A CN201210384256 A CN 201210384256A CN 102973728 A CN102973728 A CN 102973728A
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China
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parts
chinese herbal
infectious bronchitis
chicken
herbal medicine
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CN2012103842568A
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栾必荣
栾勇
顾文松
卢建平
张峰
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Zhenjiang Tianhe Biotechnology Co Ltd
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Zhenjiang Tianhe Biotechnology Co Ltd
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Priority to CN2012103842568A priority Critical patent/CN102973728A/en
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Abstract

The invention relates to a Chinese herbal medicine preparation for treating chicken infectious bronchitis. The Chinese herbal medicine preparation is prepared via ultra-fine pulverization of the following raw materials, by weight, 8-12 parts of folium eriobotryae, 11-14 parts of herba houttuyniae, 4-6 parts of venenum bufonis skins, 6-9 parts of radix astragali, 4-6 parts of polygonum cuspidatum, 4-6 parts of folium isatidis and 4-6 parts of angelica sinensis. The Chinese herbal medicine preparation contains no antibiotics and chemical synthetic drugs, has relatively obvious effect for treating chicken infectious bronchitis, has no biological toxicity, has low cost, and is economic and practical. The ultra-fine pulverization technology increases the absorption availability and efficacy of drug materials, so that a comprehensive utilization effect of the raw materials is increased.

Description

A kind of Chinese herbal and crude drugs preparations for the treatment of infectious bronchitis of chicken
Technical field
The present invention relates to a kind of Chinese herbal and crude drugs preparations, be specifically related to a kind of Chinese herbal and crude drugs preparations for the treatment of infectious bronchitis of chicken.
Background technology
Infectious bronchitis of chicken (infections bronchitis, IB) be infectious bronchitis virus (Infections bronchitis virus by the coronaviridae coronavirus genus, the respiratory tract disease of a kind of acute height contagiousness that IBV) causes, it is characterized by that the disease pertussis is coughed, sneeze, trachea rale, children chicken rhinorrhea, laying hen egg yield descends, the sick chicken kidney enlargement of kidney type, pale and a large amount of urate deposition etc. are arranged.Infectious bronchitis all might occur throughout the year, and it is wide to distribute, and spread speed is fast, and M ﹠ M is all very high.Although prevent now the vaccine of infectious bronchitis of chicken a lot, the immuning failure phenomenon happens occasionally, and has caused very large economic loss to the raiser.
Chinese herbal medicine is the treasure of China, continue to use with a long history, before more than 2000 years with regard to the record of useful Chinese herbal medicine diseases prevention.Along with the development of the intensive production of modern aviculture, antibiotic, synthetic antimicrobial class medicine and biovaccine etc. are widely used in poultry disease prevention and control and the breeding production, cause animal to produce drug resistance and toxic and side effects, and Chinese herbal medicine then has the advantage of self uniqueness.In sum, there is no under the prerequisite of specific medicament at present treatment chicken infectious disease bronchitis, there is defective in the malicious vaccine of living a little less than using inactivated vaccine, causing, during the high-tech biovaccines such as recombinant vaccine not yet promote, popularize situation, development also uses Chinese herbal compound preparation treatment infectious bronchitis of chicken to become the inexorable trend of society and development in science and technology, also possesses vast potential for future development simultaneously.
Summary of the invention
Development purpose of the present invention is to provide a kind of Chinese herbal and crude drugs preparations for the treatment of infectious bronchitis of chicken, and this Chinese herbal and crude drugs preparations has comparatively significantly curative effect to infectious bronchitis of chicken.The Chinese herbal and crude drugs preparations for the treatment of infectious bronchitis of chicken of the present invention is prepared from by Folium Eriobotryae, Herba Houttuyniae, Venenum Bufonis skin, the Radix Astragali, Rhizoma Polygoni Cuspidati, Folium Isatidis, Radix Angelicae Sinensis, the weight proportion scope of crude drug is: 8~12 parts of Folium Eriobotryaes, 11~14 parts of Herba Houttuyniae, 4~6 parts of Venenum Bufonis skins, 6~9 parts of the Radixs Astragali, 4~6 parts of Rhizoma Polygoni Cuspidati, 4~6 parts of Folium Isatidiss, 4~6 parts of Radix Angelicae Sinensis.The said herbal medicine raw material is made granularity less than the brown powder of 10 μ m after micronizing, mixing.The crude drug of this Chinese herbal and crude drugs preparations weight proportion commonly used is: 10 parts of Folium Eriobotryaes, 13 parts of Herba Houttuyniae, 5 parts of Venenum Bufonis skins, 7 parts of the Radixs Astragali, 5 parts of Rhizoma Polygoni Cuspidati, 5 parts of Folium Isatidiss, 5 parts of Radix Angelicae Sinensis.
The pharmacology of each crude drug and use as follows in the Chinese herbal and crude drugs preparations for the treatment of infectious bronchitis of chicken of the present invention:
(1) Folium Eriobotryae: peace gastric qi, profit cardiopulmonary, nourishing the liver and kidney.
(2) Herba Houttuyniae: containing decanoylacetaldehyde (is houttuynine sodium bisulfite, Decanoyl acetaldehyde), lauryl aldehyde (Lauraldehyde), methyln nonyl ketone (2-Undecano-ne), Flos Caryophylli alkene (Caryophyllene) etc., heat-clearing and toxic substances removing.Herba Houttuyniae can strengthen the phagocytic activity of WBC, improves the serum properdin, and when the treatment chronic tracheitis, Sodium Houttuyfonate can make patient WBC that the staphylococcic phagocytic activity of white is obviously improved, and the serum properdin obviously raises.Rabbit intramuscular injection every day houttuynine sodium bisulfite 8mg.Behind the successive administration 3 days, properdin also obviously raises in the serum, and Herba Houttuyniae improves immunity of organisms, and the treatment of infectious disease is had great significance.
(3) Venenum Bufonis skin: Venenum Bufonis is the secretions of Bufo siccus epidermis body of gland, white emulsion liquid.Venenum Bufonis is to be processed from strand by the ear rear gland of the amphibious reptile of Bufonidae and skin gland secretion thing, is the Chinese medicine material.Several functions such as the bioactive substances such as the contained steroidal thing of Venenum Bufonis, alkaloid have detoxifcation, ease pain, have one's ideas straightened out, antitumor and being widely used.
(4) Radix Astragali: the Chinese crude drug Radix Astragali is the root of leguminous herbaceous plant's Radix Astagali, Radix Astragali.The medicinal so far history in existing more than 2000 year of the Radix Astragali, modern study, the Radix Astragali contain the various trace elements such as Saponin, sucrose, polysaccharide, several amino acids, folic acid and selenium, zinc, copper.The enhancing human body immunity function arranged, protect the liver, diuresis, defying age, anti-stress, blood pressure lowering and antibacterial action more widely.
(5) Rhizoma Polygoni Cuspidati: Rhizoma Polygoni Cuspidati is rhizome and the root of polygonaceae plant Rhizoma Polygoni Cuspidati.Rhizoma Polygoni Cuspidati is perennial shrub shape draft, is born in by gully, the river, small stream limit, the dark and damp place of sylvan life.Heat-clearing and toxic substances removing, promoting the function of the gallbladder to alleviate jaundice, expelling wind and removing dampness, dissipating blood stasis analgesic therapy, relieving cough and resolving phlegm.
(6) Folium Isatidis: Folium Isatidis is mainly used in pyretic toxicity and sends out the diseases such as speckle, erysipelas, laryngopharynx swelling and pain, aphtha of the mouth and tongue, sore and toxic.In recent years clinically extensive use of this medicine.
(7) Radix Angelicae Sinensis: function cures mainly: enrich blood and invigorate blood circulation.
Various raw materials in the Chinese herbal and crude drugs preparations component for the treatment of infectious bronchitis of chicken of the present invention are all from domestic.
When making, can carry out according to the Chinese crude drug processing method of routine:
Respectively raw material is carried out micronizing with known superfine communication technique;
Packing after will fully mixing according to above-mentioned proportioning through the component of micronizing.
The Chinese herbal and crude drugs preparations finished product for the treatment of infectious bronchitis of chicken of the present invention is powder, and outward appearance is granularity less than the brown powder of 10 μ m.
The Chinese herbal and crude drugs preparations for the treatment of infectious bronchitis of chicken of the present invention has the following advantages: use superfine communication technique to carry out the pulverization process of Chinese medicine among (1) the present invention, the sporoderm-broken rate of crude drug cell wall is reached more than 95%, so that the effective ingredient of medical material fully discharges, enlarge the contact area with the chicken Digestive system, greatly improved the absorption rate of effective ingredient, Effective Raise the present invention is to the comprehensive utilization effect of raw material; (2) use traceization, addition is low, and application cost is low; (3) pure Chinese herbal and crude drugs preparations does not contain any antibiotic and chemical synthetic drug, and degree of safety is high.
The specific embodiment:
Below be embodiments of the invention, the actual use of the present invention is not limited to embodiment.
Embodiment one:
Take by weighing by weight 8 parts of Folium Eriobotryaes, 11 parts of Herba Houttuyniae, 4 parts of Venenum Bufonis skins, 6 parts of the Radixs Astragali, 4 parts of Rhizoma Polygoni Cuspidati, 4 parts of Folium Isatidiss, 4 parts of Radix Angelicae Sinensis.
Above-mentioned each component is carried out packing behind micronizing and the mix homogeneously, and the Chinese herbal and crude drugs preparations of the treatment infectious bronchitis of chicken of present embodiment is powder, and outward appearance is granularity less than the brown powder of 10 μ m.
Embodiment two:
Take by weighing by weight 12 parts of Folium Eriobotryaes, 14 parts of Herba Houttuyniae, 6 parts of Venenum Bufonis skins, 9 parts of the Radixs Astragali, 6 parts of Rhizoma Polygoni Cuspidati, 6 parts of Folium Isatidiss, 6 parts of Radix Angelicae Sinensis.
Above-mentioned each component is carried out packing behind micronizing and the mix homogeneously, and the Chinese herbal and crude drugs preparations of the treatment infectious bronchitis of chicken of present embodiment is powder, and outward appearance is granularity less than the brown powder of 10 μ m.
Embodiment three:
Take by weighing by weight 10 parts of Folium Eriobotryaes, 13 parts of Herba Houttuyniae, 5 parts of Venenum Bufonis skins, 7 parts of the Radixs Astragali, 5 parts of Rhizoma Polygoni Cuspidati, 5 parts of Folium Isatidiss, 5 parts of Radix Angelicae Sinensis.
Above-mentioned each component is carried out packing behind micronizing and the mix homogeneously, and the Chinese herbal and crude drugs preparations of the treatment infectious bronchitis of chicken of present embodiment is powder, and outward appearance is granularity less than the brown powder of 10 μ m.
Embodiment four:
Take by weighing by weight 9 parts of Folium Eriobotryaes, 12 parts of Herba Houttuyniae, 4 parts of Venenum Bufonis skins, 6 parts of the Radixs Astragali, 4 parts of Rhizoma Polygoni Cuspidati, 4 parts of Folium Isatidiss, 4 parts of Radix Angelicae Sinensis.
Above-mentioned each component is carried out packing behind micronizing and the mix homogeneously, and the Chinese herbal and crude drugs preparations of the treatment infectious bronchitis of chicken of present embodiment is powder, and outward appearance is granularity less than the brown powder of 10 μ m.
Embodiment five:
Take by weighing by weight 11 parts of Folium Eriobotryaes, 11 parts of Herba Houttuyniae, 6 parts of Venenum Bufonis skins, 8 parts of the Radixs Astragali, 4 parts of Rhizoma Polygoni Cuspidati, 6 parts of Folium Isatidiss, 5 parts of Radix Angelicae Sinensis.
Above-mentioned each component is carried out packing behind micronizing and the mix homogeneously, and the Chinese herbal and crude drugs preparations of the treatment infectious bronchitis of chicken of present embodiment is powder, and outward appearance is granularity less than the brown powder of 10 μ m.
Test example:
The Chinese herbal and crude drugs preparations of the treatment infectious bronchitis of chicken that will make according to above-described embodiment three uses, and observes effect.
In April, 2012, the laying hen of laying hen field, Yangzhong City has infected infectious bronchitis, has caused great economic loss for the laying hen field.Clinical symptoms: the young chicken main manifestations below 4 ages in week is for stretching the symptoms such as neck, mouth breathing, cough, sneeze, breathing rale.2 ages in week are with interior chicken, also common nasal sinuses swelling, flow nose liquid, shed tears, again and again get rid of first-class.The rehabilitation chicken is mostly dysplasia then, and emaciated physique, laying chickling also can have a strong impact on or completely lose egg laying performance because of the fallopian tube damage.Age in 5-6 week, above chicken disease symptom was similar to young chicken, but " snore " abnormal breathing sound that causes because of a large amount of secretions of delay in the trachea is more obvious, especially the most clear with night.In addition, the less phenomenon of seeing stream nose liquid.
Select young laying hen 800 plumages of Yangzhong City's chicken house natural infection infectious bronchitis, be divided at random high, medium and low dosage group and the blank group of Chinese herbal and crude drugs preparations, the Chinese herbal medicine group 2 times/d, is used in conjunction 5d with the administration of Chinese herbal and crude drugs preparations spice; The not administration of blank group, 1 week was added up curative effect after processing.Therapeutic outcome shows, Chinese medicine is high, the cure rate of middle dosage group and total effective rate be apparently higher than blank group and low dose group, significant difference (P<0.05).Conclusion: the Chinese herbal and crude drugs preparations of this treatment infectious bronchitis of chicken has certain curative effect to infectious bronchitis of chicken.

Claims (2)

1. Chinese herbal and crude drugs preparations for the treatment of infectious bronchitis of chicken, it is characterized in that: its crude drug weight proportion scope is: 8~12 parts of Folium Eriobotryaes, 11~14 parts of Herba Houttuyniae, 4~6 parts of Venenum Bufonis skins, 6~9 parts of the Radixs Astragali, 4~6 parts of Rhizoma Polygoni Cuspidati, 4~6 parts of Folium Isatidiss, 4~6 parts of Radix Angelicae Sinensis.
2. a kind of Chinese herbal and crude drugs preparations for the treatment of infectious bronchitis of chicken according to claim 1 is characterized in that described medical material after micronizing, mixing, and the gained granularity is less than the brown powder of 10 μ m.
CN2012103842568A 2012-10-11 2012-10-11 Chinese herbal medicine preparation for treating chicken infectious bronchitis Pending CN102973728A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105519812A (en) * 2016-01-01 2016-04-27 闫冷 Chick infectious broncheitis treatment feed additive
CN109528856A (en) * 2017-09-21 2019-03-29 扬中牧乐药业有限公司 A kind of spray for preventing chicken respiratory tract disease

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105519812A (en) * 2016-01-01 2016-04-27 闫冷 Chick infectious broncheitis treatment feed additive
CN109528856A (en) * 2017-09-21 2019-03-29 扬中牧乐药业有限公司 A kind of spray for preventing chicken respiratory tract disease

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Application publication date: 20130320