CN103083524A - Traditional Chinese medicine granules used for treating chicken aspergillosis, and preparation method thereof - Google Patents
Traditional Chinese medicine granules used for treating chicken aspergillosis, and preparation method thereof Download PDFInfo
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- CN103083524A CN103083524A CN2011103309687A CN201110330968A CN103083524A CN 103083524 A CN103083524 A CN 103083524A CN 2011103309687 A CN2011103309687 A CN 2011103309687A CN 201110330968 A CN201110330968 A CN 201110330968A CN 103083524 A CN103083524 A CN 103083524A
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- 239000003814 drug Substances 0.000 title claims abstract description 30
- 241000287828 Gallus gallus Species 0.000 title claims abstract description 23
- 239000008187 granular material Substances 0.000 title claims abstract description 21
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 201000002909 Aspergillosis Diseases 0.000 title claims abstract 3
- 208000036641 Aspergillus infections Diseases 0.000 title claims abstract 3
- 241000628997 Flos Species 0.000 claims abstract description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 7
- 239000006228 supernatant Substances 0.000 claims abstract description 5
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims abstract description 4
- 229930006000 Sucrose Natural products 0.000 claims abstract description 4
- 239000005720 sucrose Substances 0.000 claims abstract description 4
- 201000010099 disease Diseases 0.000 claims description 20
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 20
- 239000002994 raw material Substances 0.000 claims description 11
- 241000228212 Aspergillus Species 0.000 claims description 9
- 239000000706 filtrate Substances 0.000 claims description 3
- 239000012467 final product Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 238000005469 granulation Methods 0.000 claims description 3
- 230000003179 granulation Effects 0.000 claims description 3
- 241000207929 Scutellaria Species 0.000 claims description 2
- 229940079593 drug Drugs 0.000 abstract description 7
- 230000000694 effects Effects 0.000 abstract description 3
- 206010059866 Drug resistance Diseases 0.000 abstract description 2
- 238000001035 drying Methods 0.000 abstract 2
- 238000012216 screening Methods 0.000 abstract 2
- 241000605372 Fritillaria Species 0.000 abstract 1
- 240000004670 Glycyrrhiza echinata Species 0.000 abstract 1
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 abstract 1
- 244000299790 Rheum rhabarbarum Species 0.000 abstract 1
- 235000009411 Rheum rhabarbarum Nutrition 0.000 abstract 1
- 229910052927 chalcanthite Inorganic materials 0.000 abstract 1
- 241000411851 herbal medicine Species 0.000 abstract 1
- 229940010454 licorice Drugs 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
- 238000005303 weighing Methods 0.000 abstract 1
- 235000013330 chicken meat Nutrition 0.000 description 18
- 239000004615 ingredient Substances 0.000 description 7
- FIVPIPIDMRVLAY-UHFFFAOYSA-N aspergillin Natural products C1C2=CC=CC(O)C2N2C1(SS1)C(=O)N(C)C1(CO)C2=O FIVPIPIDMRVLAY-UHFFFAOYSA-N 0.000 description 6
- FIVPIPIDMRVLAY-RBJBARPLSA-N gliotoxin Chemical compound C1C2=CC=C[C@H](O)[C@H]2N2[C@]1(SS1)C(=O)N(C)[C@@]1(CO)C2=O FIVPIPIDMRVLAY-RBJBARPLSA-N 0.000 description 6
- 206010011224 Cough Diseases 0.000 description 4
- 210000004072 lung Anatomy 0.000 description 4
- 230000037396 body weight Effects 0.000 description 3
- 239000003651 drinking water Substances 0.000 description 3
- 235000020188 drinking water Nutrition 0.000 description 3
- 208000000059 Dyspnea Diseases 0.000 description 2
- 206010013975 Dyspnoeas Diseases 0.000 description 2
- 206010062717 Increased upper airway secretion Diseases 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 208000026435 phlegm Diseases 0.000 description 2
- 210000000582 semen Anatomy 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 208000003322 Coinfection Diseases 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 238000009361 aviculture Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 244000144977 poultry Species 0.000 description 1
- 235000013594 poultry meat Nutrition 0.000 description 1
- 208000037920 primary disease Diseases 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses traditional Chinese medicine granules used for treating chicken aspergillosis, and a preparation method thereof. The traditional Chinese medicine granules are composed of the following drugs of, by weight, 3-5 parts of radix asparagi, 3-5 parts of fritillaria, 1-3 parts of rhubarb, 1-3 parts of radix scutellariae, 1-3 parts of pollen, 1-3 parts of radix platycodi, 1-3 parts of flos farfarae, 1-2 parts of licorice and 1-3 parts of chalcanthite. The traditional Chinese medicine granules are prepared by the following steps of weighing the above nine drugs, adding water with an amount of 10 times that of the drugs, decocting for two times (2.0 hours for the first time, and 1.5 hours for the second time), mixing two filter solutions, standing for 24 hours, taking the supernatant, concentrating the supernatant to a relative density of the solution being 1.28 (80 DEG C), drying at a temperature of 60-70 DEG C, smashing, adding sucrose, mixing uniformly, making into granules by using 85% alcohol, screening by a 10-mesh screen, drying at a temperature of 60 DEG C, and screening again by the 10-mesh screen. The drug provided by the invention is a Chinese herbal medicine preparation and has the advantages of definite curative effect, no drug resistance and no residues.
Description
Technical field
The invention belongs to the poultry field of Chinese medicines, relate in particular to a kind of Chinese medicine granules that is used for the treatment of aspergillus disease of chicken and preparation method thereof.
Background technology
Aspergillus disease of chicken by multiple mycete mixed infection cause, infectious disease take respiratory inflammation as principal character, claim again the mycotic pneumonia.It is regardless of can occur in age in days, kind and the season of chicken, but comparatively easy at the plum rain season of warm moist, and is the most serious with the chickling infringement of falling ill.This disease cardinal symptom is dyspnea, breathe, being issued on property special " noisy mute " sound sometimes.The sick visible air bag of chicken post mortem and lung have the little stagnation of QI of canescence, and be as granular in Semen setariae.Aspergillus disease of chicken there is no special effect medicine therapeutic at present, and the present invention changes present situation, to treating this disease, significant curative effect is arranged.
Summary of the invention
The objective of the invention is effectively to treat Chinese medicine granules of aspergillus disease of chicken and preparation method thereof for aviculture provides a kind of.
A kind of aspergillus disease of chicken Chinese medicine granules that is used for the treatment of of the present invention, by following ingredients, count by weight:
3～5 parts of Radix Asparagis, 3～5 parts of Bulbus Fritillariae Uninbracteataes, 1～3 part of Radix Et Rhizoma Rhei, 1～3 part of Radix Scutellariae, 1～3 part of pollen, 1～3 part of Radix Platycodonis, 1～3 part of Flos Farfarae, 1～2 part, Radix Glycyrrhizae, 1～3 part, Chalcanthitum.
Above-mentioned Chinese medicine granules preferred ingredient is: 4 parts of Radix Asparagis, 4 parts of Bulbus Fritillariae Uninbracteataes, 3 parts of Radix Et Rhizoma Rhei, 3 parts of Radix Scutellariaes, 3 parts of pollen, 3 parts of Radix Platycodoniss, 3 parts of Flos Farfaraes, 1 part, Radix Glycyrrhizae, 3 parts, Chalcanthitum.
A kind of preparation method that is used for the treatment of the Chinese medicine granules of aspergillus disease of chicken, carry out as follows:
(1) take by weight: 3～5 parts of Radix Asparagis, 3～5 parts of Bulbus Fritillariae Uninbracteataes, 1～3 part of Radix Et Rhizoma Rhei, 1～3 part of Radix Scutellariae, 1～3 part of pollen, 1～3 part of Radix Platycodonis, 1～3 part of Flos Farfarae, 1～2 part, Radix Glycyrrhizae, 1～3 part, Chalcanthitum is as raw material;
(2) with above 9 flavor raw materials, add 10 times of decoctings and boil (2.0 hours, 1.5 hours) twice, merge twice filtrate, standing 24 hours, get supernatant, be concentrated into relative density 1.28(80 ℃), pulverize after 60～70 ℃ of oven dry, add sucrose, mixing, cross 10 mesh sieves with 85% ethanol granulation, 60 ℃ of oven dry are after 10 mesh sieves and get final product.
Described Chinese medicine all meets " Chinese veterinary pharmacopoeia " version two ministerial standards in 2005.
Composition principle of the present invention is: Radix Asparagi nourishing the lung to arrest cough in the side, and the Bulbus Fritillariae Uninbracteatae preventing phlegm from forming and stopping coughing, the heat clearing away eliminating stagnation is principal agent.Be aided with Radix Et Rhizoma Rhei except stagnant heat and fall disease, Radix Scutellariae purte the white and the pain that disappears, Flos Farfarae nourishing the lung to keep the adverse QI downward, preventing phlegm from forming and stopping coughing, the cough-relieving of pollen clearing throat.Assistant is controlled the wind disease with Chalcanthitum, the Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.Beneficial effect of the present invention: the present invention is pure Chinese medicinal preparation, is difficult for producing drug resistance, and chicken aspergillin disease is had good therapeutic effect, has improved present primary disease without the situation of specific medicament.
The specific embodiment
Below in conjunction with preferred embodiment, to details are as follows according to the specific embodiment provided by the invention:
Embodiment 1
A kind of Chinese medicine granules that is used for the treatment of chicken aspergillin disease, by every part of following ingredients by 10g:
Radix Asparagi 10g, Bulbus Fritillariae Uninbracteatae 40g, Radix Et Rhizoma Rhei 20g, Radix Scutellariae 30g, pollen 20g, Radix Platycodonis .30g, Flos Farfarae 30g, Radix Glycyrrhizae 20g, Chalcanthitum 10g is as raw material;
With above 9 flavor raw materials, add 10 times of decoctings and boil (2.0 hours, 1.5 hours) twice, merge twice filtrate, standing 24 hours, get supernatant, be concentrated into relative density 1.28(80 ℃), pulverize after 60～70 ℃ of oven dry, add sucrose, mixing, cross 10 mesh sieves with 85% ethanol granulation, 60 ℃ of oven dry are after 10 mesh sieves and get final product.
Embodiment 2
A kind of Chinese medicine granules that is used for the treatment of chicken aspergillin disease, by following ingredients, every part by 10g:
Radix Asparagi 30g, Bulbus Fritillariae Uninbracteatae 30g, Radix Et Rhizoma Rhei 30g, Radix Scutellariae 20g, pollen 20g, Radix Platycodonis 30g, Flos Farfarae 30g, Radix Glycyrrhizae 10g, Chalcanthitum 30g is as raw material;
Above-mentioned Chinese medicine granules and preparation method thereof is undertaken by embodiment 1
Embodiment 3
A kind of Chinese medicine granules that is used for the treatment of chicken aspergillin disease, by following ingredients, every part by 10g:
Radix Asparagi 30g, Bulbus Fritillariae Uninbracteatae 30g, Radix Et Rhizoma Rhei 20g, Radix Scutellariae 20g, pollen 10g, Radix Platycodonis 20g, Flos Farfarae 10g part, Radix Glycyrrhizae 10g, Chalcanthitum 30g is as raw material;
Above-mentioned Chinese medicine granules and preparation method thereof is undertaken by embodiment 1.
Embodiment 4
A kind of Chinese medicine granules that is used for the treatment of chicken aspergillin disease, by following ingredients, every part by 10g:
Radix Asparagi 40g, Bulbus Fritillariae Uninbracteatae 40g, Radix Et Rhizoma Rhei 30g, Radix Scutellariae 30g, pollen 30g, Radix Platycodonis 30g, Flos Farfarae 30g, Radix Glycyrrhizae 10g, Chalcanthitum 30g is as raw material;
Above-mentioned Chinese medicine granules and preparation method thereof is undertaken by embodiment 1.
Clinical trial:
Medicine of the present invention is pressed the 0.08g/kg body weight, and the drinking-water administration is used in conjunction 3～5 days.Absorb by gastrointestinal the purpose that reaches the treatment disease after oral.
For example: on December 9th, 2009, certain raiser raise 2000 chickens morbidities, clinical symptoms: dyspnea, breathe, send special " noisy mute " sound.The sick visible air bag of chicken post mortem and lung have the little stagnation of QI of canescence, as granular in Semen setariae, be that the chicken aspergillin is sick through professional Disease Diagnosis of Veterinary, then use Drug therapy of the present invention, press the 0.08g/kg body weight, the drinking-water administration, after medication 4 days, the state of an illness takes a turn for the better to some extent, breathes, breathes and recover normal, and " hoarse " sound disappears.Medicine of the present invention is pressed the 0.08g/kg body weight, and the drinking-water administration is used in conjunction 5 days, with administration chicken not relatively, breathe normally, there are no " noisy mute " sound, cut open inspection there are no the little stagnation of QI of canescence.
The above is only preferred embodiment of the present invention, is not structure of the present invention is done any pro forma restriction.Every foundation technical spirit of the present invention all still belongs in the scope of technical scheme of the present invention any simple modification, equivalent variations and modification that above embodiment does.
Claims (3)
1. Chinese medicine granules that is used for the treatment of aspergillus disease of chicken is characterized in that: be comprised of the following raw materials according component, by weight meter:
3～5 parts of Radix Asparagis, 3～5 parts of Bulbus Fritillariae Uninbracteataes, 1～3 part of Radix Et Rhizoma Rhei, 1～3 part of Radix Scutellariae, 1～3 part of pollen, 1～3 part of Radix Platycodonis, 1～3 part of Flos Farfarae, 1～2 part, Radix Glycyrrhizae, 1～3 part, Chalcanthitum.
2. the Chinese medicine granules for the treatment of according to claim 1 chicken aspergillosis is characterized in that: be comprised of the following raw materials according component:
4 parts of Radix Asparagis, 4 parts of Bulbus Fritillariae Uninbracteataes, 3 parts of Radix Et Rhizoma Rhei, 3 parts of Radix Scutellariaes, 3 parts of pollen, 3 parts of Radix Platycodoniss, 3 parts of Flos Farfaraes, 1 part, Radix Glycyrrhizae, 3 parts, Chalcanthitum.
3. a Chinese medicine granules preparation method that is used for the treatment of aspergillus disease of chicken, is characterized in that, carries out as follows:
(1) take by weight: 3～5 parts of Radix Asparagis, 3～5 parts of Bulbus Fritillariae Uninbracteataes, 1～3 part of Radix Et Rhizoma Rhei, 1～3 part of Radix Scutellariae, 1～3 part of pollen, 1～3 part of Radix Platycodonis, 1～3 part of Flos Farfarae, 1～2 part, Radix Glycyrrhizae, 1～3 part, Chalcanthitum is as raw material;
(2) with above 9 flavor raw materials, the decocting that adds 10 times of amounts boils twice, decocts for the first time 2.0 hours, decocts for the second time 1.5 hours; Merge filtrate twice, standing 24 hours, get supernatant, be concentrated into relative density 1.28(80 ℃), pulverize after 60～70 ℃ of oven dry, add sucrose, mixing, cross 2000 μ m ± 70 μ m sieves with 85% ethanol granulation, 60 ℃ of oven dry are sieved and get final product after 2000 μ m ± 70 μ m.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011103309687A CN103083524A (en) | 2011-10-27 | 2011-10-27 | Traditional Chinese medicine granules used for treating chicken aspergillosis, and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2011103309687A CN103083524A (en) | 2011-10-27 | 2011-10-27 | Traditional Chinese medicine granules used for treating chicken aspergillosis, and preparation method thereof |
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| CN103083524A true CN103083524A (en) | 2013-05-08 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103947893A (en) * | 2014-05-14 | 2014-07-30 | 山东新希望六和集团有限公司 | Feed and traditional Chinese medicine composition for preventing and treating duck aspergillosis and preparation method of feed |
| CN105833227A (en) * | 2016-05-12 | 2016-08-10 | 郎溪县鑫旺畜牧养殖有限公司 | Pheasant aspergillosis preventing and control agent |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1358534A (en) * | 2001-12-14 | 2002-07-17 | 王志强 | Compound medicine for treating bronchial asthma and preparation process |
| CN1981859A (en) * | 2005-12-15 | 2007-06-20 | 天津中新药业集团股份有限公司 | Chinese-medicinal extract with liver-clearing and phlegm-resolving functions and its production |
-
2011
- 2011-10-27 CN CN2011103309687A patent/CN103083524A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1358534A (en) * | 2001-12-14 | 2002-07-17 | 王志强 | Compound medicine for treating bronchial asthma and preparation process |
| CN1981859A (en) * | 2005-12-15 | 2007-06-20 | 天津中新药业集团股份有限公司 | Chinese-medicinal extract with liver-clearing and phlegm-resolving functions and its production |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103947893A (en) * | 2014-05-14 | 2014-07-30 | 山东新希望六和集团有限公司 | Feed and traditional Chinese medicine composition for preventing and treating duck aspergillosis and preparation method of feed |
| CN105833227A (en) * | 2016-05-12 | 2016-08-10 | 郎溪县鑫旺畜牧养殖有限公司 | Pheasant aspergillosis preventing and control agent |
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Application publication date: 20130508 |