CN103432375A - Preparation method of traditional Chinese medicine extract with effects of ventilating lung, clearing heat, resolving phlegm and relieving cough - Google Patents
Preparation method of traditional Chinese medicine extract with effects of ventilating lung, clearing heat, resolving phlegm and relieving cough Download PDFInfo
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Abstract
The invention discloses a preparation method of a traditional Chinese medicine extract with effects of ventilating lung, clearing heat, resolving phlegm and relieving cough. The active ingredient is prepared from the following raw materials in parts by weight: 75 parts of perilla leaf, 75 parts of radix peucedani, 75 parts of semen armeniacae amarum (fried), 75 parts of radix asteris, 75 parts of gypsum, 50 parts of herba ephedrae, 50 parts of white mulberry root-bark, 50 parts of mint, 50 parts of bulbus fritillariae cirrhosae, 50 parts of flos farfarae, 50 parts of liquorice, 50 parts of semen trichosanthis and 25 parts of semen lepidii. The preparation method disclosed by the invention has the advantages that the quality is stable and controllable, the curative effect is obviously improved in comparison with the existing commercial dosage forms, the dosage taken by a patient is reduced, the bioavailability is improved, and the economic and social benefits are remarkable.
Description
Technical field
The invention belongs to and belong to modernization of Chinese medicine technical field, relate to the preparation method of the analgesic preventing phlegm from forming and stopping coughing Chinese medicine extract of a kind of lung qi dispersing.
Background technology
The purging pathogenic fire of the lung ball is the Chinese medicine of the at present commercially available analgesic preventing phlegm from forming and stopping coughing of a kind of lung qi dispersing, and it is made by Folium Perillae, Radix Peucedani, Semen Armeniacae Amarum (stir-fry), Radix Asteris, Gypsum Fibrosum, Herba Ephedrae, Cortex Mori, Herba Menthae, Bulbus Fritillariae Cirrhosae, Flos Farfarae, Radix Glycyrrhizae, Semen Trichosanthis, Semen Lepidii (Semen Descurainiae).But purging pathogenic fire of the lung ball lung qi dispersing is analgesic, preventing phlegm from forming and stopping coughing.For the cough due to common cold, abundant expectoration fullness in the chest, thirsty dry tongue, have a stuffy nose obstructed.Side's epheday intermedia, Semen Armeniacae Amarum, Gypsum Fibrosum, Radix Glycyrrhizae, lung qi dispersing purges heat; Folium Perillae, Radix Peucedani, Radix Asteris, Semen Lepidii (Semen Descurainiae), Cortex Mori, Semen Fructus Trichosanthis preventing phlegm from forming and stopping coughing; Flos Farfarae, Bulbus Fritillariae Cirrhosae nourishing the lung to arrest cough; The Herba Menthae relieving the exterior syndrome with drugs of pungent in flavor and cool in nature; All medicines share, and play altogether lung qi dispersing analgesic, the merit of preventing phlegm from forming and stopping coughing.The clinical cough due to common cold that is mainly used in, abundant expectoration fullness in the chest disease.
Cough is a common and multiple symptom of respiratory system disease.Cough is that external stimulation is in vagus nerve and in the irritative cough due to AP.The reason of vagus nerve stimulation is a lot, and 1. respiratory tract infection is arranged: comprise the inflammation that virus, antibacterial, mycoplasma, fungus, parasite cause; 2. chemical factors: as respiratory tract foreign body, dust, smog, temperature etc. stimulate respiratory mucosa; 3. cardiovascular factor: during as heart disease, pericarditis and pericardial effusion, because the rami cardiaci irriate causes zest dry cough; 4. tumor; 5. irritated factor; 6. neural reflex: as the abdominal part illness such as subphrenic abscess, liver abscess stimulate tabula, cause cough; 7. after infection control, if respiratory tissues damage and disturbance of blood circulation situation do not improve, the position of damage will cough by vagal stimulation in PG cause cough; 8. other: low plasma protein hydrothorax caused as liver cirrhosis, the nephrotic syndrome etc.
The prescription of purging pathogenic fire of the lung ball and method for making are: Folium Perillae 75g, Radix Peucedani 75g, Semen Armeniacae Amarum (stir-fry) 75g, Radix Asteris 75g, Gypsum Fibrosum 75g, Herba Ephedrae 50g, Cortex Mori 50g, Herba Menthae 50g, Bulbus Fritillariae Cirrhosae 50g, Flos Farfarae 50g, Radix Glycyrrhizae 50g, Semen Trichosanthis 50g, Semen Lepidii (Semen Descurainiae) 25g.By 13 flavor medical materials, be ground into fine powder, sieve, mix, every 100g powder adds refined honey 100～120g and makes big honeyed pills, obtains.
This medicine method for making is simple, evident in efficacy.But former prescription type is honeyed pill, easily goes mouldy and microbiological contamination.Take and carry inconvenience, mouthfeel is not good, the heavy 3g of every ball, and children's, old man and pharyngolaryngitis patient dysphagia, take inconvenience, and patient's acceptance level is poor.And from oral slow to the gastrointestinal absorption process.These factors directly affect purging pathogenic fire of the lung ball applying clinically.
Summary of the invention
The purpose of this invention is to provide the analgesic preventing phlegm from forming and stopping coughing Chinese medicine composition of a kind of lung qi dispersing preparation method.For realizing this purpose, the present invention by the following technical solutions:
The preparation method of the analgesic preventing phlegm from forming and stopping coughing Chinese medicine extract of a kind of lung qi dispersing is characterized in that being undertaken by following step:
(1) take each raw material by 25 parts of 75 parts of Folium Perillaes, 75 parts of Radix Peucedanis, 75 parts of Semen Armeniacae Amarums (stir-fry), 75 parts of Radix Asteriss, 75 parts, Gypsum Fibrosum, 50 parts, Herba Ephedrae, 50 parts of Cortex Mori, 50 parts of Herba Menthaes, 50 parts of Bulbus Fritillariae Cirrhosaes, 50 parts of Flos Farfaraees, 50 parts, Radix Glycyrrhizae, 50 parts of Semen Trichosanthis, Semen Lepidii (Semen Descurainiae), all the raw material water extraction is 2-3 time, extract 1-3 hour with 8-12 times of water gaging at every turn, merge extractive liquid,, being concentrated into relative density under 50-60 ℃ of condition is 1.03-1.10, obtains concentrated solution A;
(2) will add the ethanol that concentration of volume percent is 90%-98% in concentrated solution A, precipitation, standing, obtain supernatant B; In supernatant B, the ethanol concentration of volume percent is 40%-80%;
(3) supernatant B being concentrated into to relative density under 50-60 ℃ of condition is 1.03-1.10, obtains concentrated solution C; By concentrated solution C drying under reduced pressure or spray drying, obtain dry thing;
(4) by the dry thing and the acceptable pharmaceutic adjuvant mf mass pil of pharmaceutics, tablet, capsule or the oral liquid that obtain.
The preparation method of the analgesic preventing phlegm from forming and stopping coughing Chinese medicine extract of the preferred lung qi dispersing of the present invention, wherein said active component adopts following method to prepare: by proportioning raw materials, take each raw material; Described whole medical material water extraction 2 times is extracted 2 hours with 10 times of water gagings at every turn, merge extractive liquid,, and being concentrated into relative density under 50-60 ℃ of condition is 1.05-1.08, obtains concentrated solution A; To add the ethanol that percent by volume is 95% in concentrated solution A, precipitation, standing, obtain supernatant B; Making ethanol concentration of volume percent in supernatant B is 50%-70%; It is 1.05-1.08 that supernatant B is concentrated into to relative density under 50-60 ℃ of condition, obtains concentrated solution C; By concentrated solution C drying under reduced pressure or spray drying, obtain dry thing; By dry thing and the acceptable pharmaceutic adjuvant mf mass pil of pharmaceutics, tablet, capsule or the oral liquid obtained.
The acceptable pharmaceutic adjuvant of pharmaceutics of the present invention is selected from any one or a few in starch, microcrystalline Cellulose, sucrose, aspartame, dextrin, lactose, Icing Sugar, glucose, sodium chloride, sodium carboxymethyl cellulose, crospolyvinylpyrrolidone, magnesium stearate, micropowder silica gel, vitamin C, cysteine, citric acid and sodium sulfite.
The Chinese medicine composition that technical solution of the present invention is related and preparation thereof all have that good lung qi dispersing is analgesic, the preventing phlegm from forming and stopping coughing effect.Can be used for treating the cough due to common cold, the abundant expectoration fullness in the chest, thirsty dry tongue, have a stuffy nose obstructed.By zoopery, we unexpectedly find, pharmaceutical composition prepared by technique of the present invention is compared with former dosage form, have excellent eliminating the phlegm and antitussive effect.
Advantage of the present invention is: the present invention uses theory of Chinese medical science analysis prescription to form, and according to the physicochemical property of each flavour of a drug ingredient and the result of study of pharmacological action, research has obtained the preparation method of reasonable, stable active component.Adopt technical solution of the present invention, prepared pharmaceutical preparation stable and controllable for quality, that curative effect is compared with existing commercially available dosage form and significantly improved, patient's taking dose reduces, bioavailability improves, there is significant economic and social benefit.
Describe by the following examples technical solution of the present invention in detail, with this, do not limit practical range of the present invention.
The specific embodiment
Below in conjunction with embodiment, the present invention is further described, and following embodiment is illustrative, is not determinate, can not limit protection scope of the present invention with following embodiment.Various traditional Chinese medicinal material raw materials of the present invention all has commercially available.
Embodiment 1:
Prepare Chinese medicine extract
One. prescription: Folium Perillae 75g, Radix Peucedani 75g, Semen Armeniacae Amarum (stir-fry) 75g, Radix Asteris 75g, Gypsum Fibrosum 75g, Herba Ephedrae 50g, Cortex Mori 50g, Herba Menthae 50g, Bulbus Fritillariae Cirrhosae 50g, Flos Farfarae 50g, Radix Glycyrrhizae 50g, Semen Trichosanthis 50g, Semen Lepidii (Semen Descurainiae) 25g
Two. method for making:
Take each raw material by proportioning raw materials, standby; All medical material extracts with 10 times of amounts, 8 times of water gagings respectively, each 2h, and merge extractive liquid,, being concentrated into relative density under 50-60 ℃ of condition is 1.03, obtains concentrated solution A; To add the ethanol that concentration of volume percent is 95% in concentrated solution A, precipitation, standing, making ethanol concentration of volume percent in supernatant B is 40%.It is 1.05 that supernatant B is concentrated into to relative density under 50-60 ℃ of condition, obtains concentrated solution C; By concentrated solution C drying under reduced pressure or spray drying, obtain dry thing, be active constituents of medicine 165 grams of the present invention.
Embodiment 2:
Prepare Chinese medicine extract
One. prescription: Folium Perillae 750g, Radix Peucedani 750g, Semen Armeniacae Amarum (stir-fry) 750g, Radix Asteris 750g, Gypsum Fibrosum 750g, Herba Ephedrae 500g, Cortex Mori 500g, Herba Menthae 500g, Bulbus Fritillariae Cirrhosae 500g, Flos Farfarae 500g, Radix Glycyrrhizae 500g, Semen Trichosanthis 500g, Semen Lepidii (Semen Descurainiae) 250g
Two. method for making:
Take each raw material by proportioning raw materials, standby; All for medical material, 10 times of amounts, 12 times of water gagings extract, each 2h, and merge extractive liquid,, being concentrated into relative density under 50-60 ℃ of condition is 1.05, obtains concentrated solution A; To add the ethanol that concentration of volume percent is 95% in concentrated solution A, precipitation, standing, making supernatant B ethanol concentration of volume percent is 50%.It is 1.05 that supernatant B is concentrated into to relative density under 50-60 ℃ of condition, obtains concentrated solution C; By concentrated solution C drying under reduced pressure or spray drying, obtain dry thing, be active constituents of medicine 1650 grams of the present invention.
Embodiment 3:
Prepare Chinese medicine extract
One. prescription: Folium Perillae 75g, Radix Peucedani 75g, Semen Armeniacae Amarum (stir-fry) 75g, Radix Asteris 75g, Gypsum Fibrosum 75g, Herba Ephedrae 50g, Cortex Mori 50g, Herba Menthae 50g, Bulbus Fritillariae Cirrhosae 50g, Flos Farfarae 50g, Radix Glycyrrhizae 50g, Semen Trichosanthis 50g, Semen Lepidii (Semen Descurainiae) 25g
Two. method for making:
Take each raw material by proportioning raw materials, standby; All for medical material, 12 times of amounts, 10 times of water gagings extract, each 1.5h, and merge extractive liquid,, being concentrated into relative density under 50-60 ℃ of condition is 1.08, obtains concentrated solution A; By adding concentration of volume percent in concentrated solution A, be 95% ethanol, precipitation, standing, making supernatant B ethanol concentration of volume percent is 60%.It is 1.08 that supernatant B is concentrated into to relative density under 50-60 ℃ of condition, obtains concentrated solution C; By concentrated solution C drying under reduced pressure or spray drying, obtain dry thing, be active constituents of medicine 150 grams of the present invention.
Embodiment 4:
Prepare Chinese medicine extract
One. prescription: Folium Perillae 75g, Radix Peucedani 75g, Semen Armeniacae Amarum (stir-fry) 75g, Radix Asteris 75g, Gypsum Fibrosum 75g, Herba Ephedrae 50g, Cortex Mori 50g, Herba Menthae 50g, Bulbus Fritillariae Cirrhosae 50g, Flos Farfarae 50g, Radix Glycyrrhizae 50g, Semen Trichosanthis 50g, Semen Lepidii (Semen Descurainiae) 25g
Two. method for making:
Take each raw material by proportioning raw materials, standby; All for medical material, 10 times of amounts, 8 times of water gagings extract, each 2h, and merge extractive liquid,, being concentrated into relative density under 50-60 ℃ of condition is 1.10, obtains concentrated solution A; To add the ethanol that concentration of volume percent is 95% in concentrated solution A, precipitation, standing, the concentration of volume percent that makes supernatant B ethanol is 70%.It is 1.08 that supernatant B is concentrated into to relative density under 50-60 ℃ of condition, obtains concentrated solution C; By concentrated solution C drying under reduced pressure or spray drying, obtain dry thing, be active constituents of medicine 130 grams of the present invention.
Embodiment 5:
Prepare Chinese medicine extract
One. prescription: Folium Perillae 75g, Radix Peucedani 75g, Semen Armeniacae Amarum (stir-fry) 75g, Radix Asteris 75g, Gypsum Fibrosum 75g, Herba Ephedrae 50g, Cortex Mori 50g, Herba Menthae 50g, Bulbus Fritillariae Cirrhosae 50g, Flos Farfarae 50g, Radix Glycyrrhizae 50g, Semen Trichosanthis 50g, Semen Lepidii (Semen Descurainiae) 25g
Two. method for making:
Take each raw material by proportioning raw materials, standby; All for medical material, 10 times of amounts, 12 times of water gagings extract, each 3h, and merge extractive liquid,, being concentrated into relative density under 50-60 ℃ of condition is 1.08, obtains concentrated solution A; By adding concentration of volume percent in concentrated solution A, be 90% ethanol, precipitation, standing, making supernatant B ethanol concentration of volume percent is 80%.It is 1.10 that supernatant B is concentrated into to relative density under 50-60 ℃ of condition, obtains concentrated solution C; By concentrated solution C drying under reduced pressure or spray drying, obtain dry thing, be active constituents of medicine 135 grams of the present invention.
Embodiment 6:
Prepare Chinese medicine extract
One. prescription: Folium Perillae 75g, Radix Peucedani 75g, Semen Armeniacae Amarum (stir-fry) 75g, Radix Asteris 75g, Gypsum Fibrosum 75g, Herba Ephedrae 50g, Cortex Mori 50g, Herba Menthae 50g, Bulbus Fritillariae Cirrhosae 50g, Flos Farfarae 50g, Radix Glycyrrhizae 50g, Semen Trichosanthis 50g, Semen Lepidii (Semen Descurainiae) 25g
Two. method for making:
Take each raw material by proportioning raw materials, standby; All for medical material, 10 times of amounts, 10 times of water gagings extract, each 2h, and merge extractive liquid,, being concentrated into relative density under 50-60 ℃ of condition is 1.05, obtains concentrated solution A; To add the ethanol that concentration of volume percent is 95% in concentrated solution A, precipitation, standing, making supernatant B ethanol concentration of volume percent is 60%.It is 1.08 that supernatant B is concentrated into to relative density under 50-60 ℃ of condition, obtains concentrated solution C; By concentrated solution C drying under reduced pressure or spray drying, obtain dry thing, be active constituents of medicine 131 grams of the present invention.
Embodiment 7:
Prepare Chinese medicine extract
One. prescription: Folium Perillae 75g, Radix Peucedani 75g, Semen Armeniacae Amarum (stir-fry) 75g, Radix Asteris 75g, Gypsum Fibrosum 75g, Herba Ephedrae 50g, Cortex Mori 50g, Herba Menthae 50g, Bulbus Fritillariae Cirrhosae 50g, Flos Farfarae 50g, Radix Glycyrrhizae 50g, Semen Trichosanthis 50g, Semen Lepidii (Semen Descurainiae) 25g
Two. method for making:
Take each raw material by proportioning raw materials, standby; All medical material extracts 1h, 10 times of water gagings extraction 3h with 8 times of water gagings, merge extractive liquid,, and being concentrated into relative density under 50-60 ℃ of condition is 1.08, obtains concentrated solution A; By adding concentration of volume percent in concentrated solution A, be 95% ethanol, precipitation, standing, making supernatant B ethanol concentration of volume percent is 60%.It is 1.05 that supernatant B is concentrated into to relative density under 50-60 ℃ of condition, obtains concentrated solution C; By concentrated solution C drying under reduced pressure or spray drying, obtain dry thing, be active constituents of medicine 140 grams of the present invention.
Embodiment 8: prepare tablet
The active component 100g that embodiment 1 obtains, add microcrystalline Cellulose 10g, lactose 10g, and cross-linked pvp 5g, tabletting, obtain tablet, and every is 0.4g.
Embodiment 9: prepare granule
The active component 500g that embodiment 2 obtains, add dextrin 100g, xylitol 400g, and citric acid 1g, aspartame 1g granulates, and obtains granule, and every bag is 0.6g.
Embodiment 10:
Zoopery one: the impact of extract of the present invention on the mice phlegm-dispelling functions
One. materials and methods
(lot number: 120867), in Tianjin, newly Pharmaceutical limited company reaches the production of core hall pharmaceutical factory to the purging pathogenic fire of the lung ball
Animal: the ICR mice is provided by Beijing Vital River Experimental Animals Technology Co., Ltd..
Ammonium chloride (lot number: 20120127), dragon Xinghua, Asia-Pacific, Tianjin work company limited
Phenol red (lot number: 20121128), rich Dihua, Tianjin work company limited
UV7504 ultraviolet-uisible spectrophotometer: Shanghai precision instrument company limited
Get 60 of healthy ICR mices, body weight 18 ~ 22g, be divided at random 5 groups, be blank group, ammonium chloride positive controls (0.5g/kg), purging pathogenic fire of the lung extract of bolus (press embodiment 2 methods preparation) is low, high dose group (3.0,6.0g crude drug/kg), purging pathogenic fire of the lung ball group (3.0g crude drug/kg), give isopyknic pure water except blank group, other administration groups are all by the continuous gastric infusion of above-mentioned dosage 7 days, and the administration volume is 20ml/kg.Fasting 12h before the last administration, 0.5 hour phenol red normal saline solution 10ml/kg of lumbar injection 5% after the last administration, 0.5 after hour, disconnected neck is put to death mice, peel off the trachea surrounding tissue, cut from the thyroid cartilage to one section trachea of trachea bifurcation, put into the test tube that fills alkaline normal saline (normal saline 2ml+1N sodium hydroxide 0.1ml) solution, after room temperature is placed 2 hours, the trachea eluent is surveyed to its absorbance with ultraviolet-uisible spectrophotometer in 546nm wavelength place, by phenol red standard curve, calculate every phenol red content of mice trachea.Experimental data is added up with variance analysis.
Two. result: in Table 1.
The table 1 extract administration impact on the mice phlegm-dispelling functions in seven days (
)
| Group | Number of animals (only) | Dosage (g crude drug/kg) | Phenol red concentration (ug/ml) |
| Blank group | 12 | —— | 1.51±0.25 |
| The ammonium chloride group | 12 | 0.5 | 2.88±0.92** |
| Purging pathogenic fire of the lung extract of bolus low dose group | 12 | 3.0 | 2.64±0.26**# |
| Purging pathogenic fire of the lung extract of bolus high dose group | 12 | 6.0 | 2.97±0.72** |
| Purging pathogenic fire of the lung ball group | 12 | 3.0 | 2.24±0.68* |
Compare * P<0.05 with the blank group, * * P<0.01 with purging pathogenic fire of the lung ball group than # P<0.05
Result shows: the purging pathogenic fire of the lung extract of bolus is low, high dose group and blank group relatively, utmost point significant difference (P<0.01) is all arranged, point out this extract can obviously promote the phenol red excretion amount of mice trachea, and present certain dose-effect relationship, illustrate that this invention extract has good phlegm-dispelling functions.Under Isodose, the purging pathogenic fire of the lung extract of bolus compares with former dosage form under Isodose, and significant difference (P<0.05) is arranged, and points out extract phlegm-dispelling functions of the present invention to be better than former dosage form.
Embodiment 11:
Zoopery two: extract of the present invention causes the impact of mouse cough on ammonia
One. materials and methods:
Purging pathogenic fire of the lung ball (lot number 120867, the big honeyed pills of mentioning in description), in Tianjin, new Pharmaceutical limited company reaches core hall pharmaceutical factory provides.
FUFANG GANCAO PIAN (lot number 120119) Tianjin Lisheng Pharmaceutical Co., Ltd.
Strong aqua ammonia: chemical reagent work is learned in Dongli District safe blue Dehua in Tianjin
Animal: the ICR mice is provided by Beijing Vital River Experimental Animals Technology Co., Ltd..
Get 60 of healthy ICR mices, body weight 18 ~ 22g, be divided at random 5 groups, blank group, FUFANG GANCAO PIAN positive controls (0.5g/kg), the purging pathogenic fire of the lung extract of bolus is low, high dose group (3.0,6.0g crude drug/kg), purging pathogenic fire of the lung ball group (3.0g crude drug/kg), give isopyknic pure water except blank group, and the positive drug FUFANG GANCAO PIAN is in experiment administration on the same day 1 time, other administration groups are all by the continuous gastric infusion of above-mentioned dosage 7 days, and the administration volume is 20ml/kg.Each group after the last administration 1 hour, mice is placed in inverted 500ml beaker, draw after the 0.3ml strong aqua ammonia injects the 50mg cotton balls and put into beaker, observe and record the cough latent period of respectively organizing mice and in 3 minutes the mouse cough number of times (typical case's cough is that the mice abdominal muscle shrinks, magnify mouth simultaneously, with coughing sound), experimental data is added up with variance analysis.
Two. result: in Table 2
The impact on ammonia initiation mouse cough in seven days of table 2 extract successive administration (
)
| Group | Number of animals (only) | Dosage (g crude drug/kg) | Incubation period (S) | Cough number of times in 3min |
| Model control group | 12 | —— | 82.4±10.3 | 30.4±6.8 |
| The FUFANG GANCAO PIAN group | 12 | 0.5 | 96.4±8.1** | 12.1±3.0** |
| Purging pathogenic fire of the lung extract of bolus low dose group | 12 | 3.0 | 93.7±12.5**# | 15.8±5.2**# |
| Purging pathogenic fire of the lung extract of bolus high dose group | 12 | 6.0 | 98.5±11.9** | 12.8±3.6** |
| Purging pathogenic fire of the lung ball group | 12 | 3.0 | 88.3±12.0* | 18.2±4.7** |
With model control group relatively, * P<0.05, * * P<0.01 with purging pathogenic fire of the lung ball group than # P<0.05
Result shows: extract is low, the cough latent period of high dose group has utmost point significant difference (P<0.01) with the model control group ratio, and other each administration groups and model control group are than there are no significant difference.Extract is low, number of times and the model control group of cough relatively has utmost point significant difference (P<0.01) in high dose group 3 minutes, prompting is 3.0, under 6.0g crude drug/kg dosage, and the purging pathogenic fire of the lung extract of bolus can obviously extend the mouse cough incubation period that ammonia induces and reduce the cough number of times.Under Isodose, the purging pathogenic fire of the lung extract of bolus all has significant difference (P<0.05) with former dosage form ratio on cough latent period and on the impact of the number of times of cough in 3 minutes, illustrates that this extract has obvious antitussive effect and effect to be better than former dosage form.
Claims (3)
1. the preparation method of the analgesic preventing phlegm from forming and stopping coughing Chinese medicine extract of lung qi dispersing is characterized in that being undertaken by following step:
(1) take each raw material by 25 parts of 75 parts of Folium Perillaes, 75 parts of Radix Peucedanis, 75 parts of Semen Armeniacae Amarums (stir-fry), 75 parts of Radix Asteriss, 75 parts, Gypsum Fibrosum, 50 parts, Herba Ephedrae, 50 parts of Cortex Mori, 50 parts of Herba Menthaes, 50 parts of Bulbus Fritillariae Cirrhosaes, 50 parts of Flos Farfaraees, 50 parts, Radix Glycyrrhizae, 50 parts of Semen Trichosanthis, Semen Lepidii (Semen Descurainiae), all the raw material water extraction is 2-3 time, extract 1-3 hour with 8-12 times of water gaging at every turn, merge extractive liquid,, being concentrated into relative density under 50-60 ℃ of condition is 1.03-1.10, obtains concentrated solution A;
(2) will add the ethanol that concentration of volume percent is 90%-98% in concentrated solution A, precipitation, standing, obtain supernatant B; In supernatant B, the ethanol concentration of volume percent is 40%-80%;
(3) supernatant B being concentrated into to relative density under 50-60 ℃ of condition is 1.03-1.10, obtains concentrated solution C; By concentrated solution C drying under reduced pressure or spray drying, obtain dry thing;
(4) by the dry thing and the acceptable pharmaceutic adjuvant mf mass pil of pharmaceutics, tablet, capsule or the oral liquid that obtain.
2. preparation method claimed in claim 1, wherein said active component adopts following method to prepare: by proportioning raw materials, take each raw material; Described whole medical material water extraction 2 times is extracted 2 hours with 10 times of water gagings at every turn, merge extractive liquid,, and being concentrated into relative density under 50-60 ℃ of condition is 1.05-1.08, obtains concentrated solution A; To add the ethanol that percent by volume is 95% in concentrated solution A, precipitation, standing, obtain supernatant B; Making ethanol concentration of volume percent in supernatant B is 50%-70%; It is 1.05-1.08 that supernatant B is concentrated into to relative density under 50-60 ℃ of condition, obtains concentrated solution C; By concentrated solution C drying under reduced pressure or spray drying, obtain dry thing; By dry thing and the acceptable pharmaceutic adjuvant mf mass pil of pharmaceutics, tablet, capsule or the oral liquid obtained.
3. the preparation method of the described Chinese medicine extract of claim 1-2 any one, the acceptable pharmaceutic adjuvant of wherein said pharmaceutics is selected from any one or a few in starch, microcrystalline Cellulose, sucrose, aspartame, dextrin, lactose, Icing Sugar, glucose, sodium chloride, sodium carboxymethyl cellulose, crospolyvinylpyrrolidone, magnesium stearate, micropowder silica gel, vitamin C, cysteine, citric acid and sodium sulfite.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103656602A (en) * | 2013-12-23 | 2014-03-26 | 青岛安信医疗器械有限公司 | Traditional Chinese medicinal decoction for treating phlegm-heat-type pneumonia |
| CN105288261A (en) * | 2015-02-12 | 2016-02-03 | 济南舜景医药科技有限公司 | Traditional Chinese medicine for treating wind-heat cough |
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Application publication date: 20131211 |