CN102058768B - Traditional Chinese medicine composition for clearing lung, eliminating phlegm and stopping cough and asthma, and preparation method thereof - Google Patents
Traditional Chinese medicine composition for clearing lung, eliminating phlegm and stopping cough and asthma, and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for clearing lung, eliminating phlegm and stopping cough and asthma, and a preparation method thereof, belonging to the modern field of traditional Chinese medicine. The traditional Chinese medicine composition comprises the following active ingredients in parts by weight: 108 parts of rhizoma anemarrhenae, 108 parts of radix scrophulariae, 216 parts of poppy shell, 108 parts of radix ophiopogonis, 324 parts of coltsfoot flower, 108 parts of aster, 108 parts of semen armeniacae amarae, 108 parts of lily and 54 parts of thunberg fritillary bulb. The traditional Chinese medicine composition has the advantages that the traditional Chinese medicine theory is used to analyze prescriptions, a research result on the physicochemical property and the pharmacological action of components contained in each medicine is obtained, and a preparation method by which the traditional Chinese medicine composition with reasonable and stable active ingredients can be obtained. The technical scheme adopted in the invention can be used for preparing the medicine preparation with stable and controllable quality, the curative effect of the medicine preparation is obviously improved as compared with the preparation formulation sold in the market at present, and the dosage taken by patients is reduced, thus having obvious economic and social benefits.
Description
Technical field
The present invention relates to Chinese medicine composition that a kind of removing heat from the lung and dissipating phlegm antitussive relievings asthma and preparation method thereof, belong to modern Chinese traditional medicine field.
Background technology
Ermuansou sheet function removing heat from the lung and dissipating phlegm, antitussive is relievingd asthma, function asthenia chronic cough, the cough phlegm dyspnea, osteopyrexia and fever, silent low voice speaking, dry mouth dry tongue, accumulation and obstruction of sputum.The clinical treatment that is used for genus lung-heat yin-deficiency persons such as pulmonary tuberculosis, chronic bronchitis.
Upper respiratory tract infection, acute/chronic bronchitis, pulmonary infection take place in winter-spring season easily.These sick most meetings are with symptoms such as cough, abundant expectoration or asthma.But Ermuansou ball clearing away lung-heat, reduce phlegm, antitussive, relieving asthma.Thick, the osteopyrexia and fever of cough expectorant that be used for pulmonary tuberculosis, chronic bronchitis, causes, silent low voice speaking, dry mouth dry tongue, accumulation and obstruction of sputum person.The clear purte the white of the Rhizoma Anemarrhenae in the side, nourishing YIN and moistening the lung; The Bulbus Fritillariae Thunbergii preventing phlegm from forming and stopping coughing is monarch drug altogether.Flos Farfarae, Radix Asteris relieving cough and resolving phlegm, the respectful lung of Semen Armeniacae Amarum is relievingd asthma, and auxilliary altogether monarch drug preventing phlegm from forming and stopping coughing is ministerial drug.Radix Scrophulariae heat clearing away eliminating stagnation, Radix Ophiopogonis nourishing YIN and moistening the lung, the Bulbus Lilii nourishing the lung to arrest cough, the Pericarpium Papaveris astringing lung-QI and relieving cough is adjuvant drug altogether.All medicines share, and play removing heat from the lung and dissipating phlegm altogether, the merit of relieving cough and asthma.
Bring up phlegm when one coughs, the traditional Chinese medical science thinks that lung-heat is one of main pathogenesis.Lung-heat divides the heresy of diseases caused by exogenous pathogenic factor wind heat, or two kinds of the back heat-transformation of catching cold.Performance with cough, to cough up phlegm and pant be primary symptom, see again to tell yellow sputum and thickness is difficult for bringing up, has a fever, has a sore throat, thirsty, uncomfortable in chest dysphoria with smothery sensation, red tongue with yellow fur, full and large pulse or sliding number etc.Modern medical diagnosis is the pneumonia that causes of upper respiratory tract infection, acute bronchitis, acute episode of chronic bronchitis and bronchopneumonia, lobar pneumonia, viral pneumonia and other reason, pulmonary heart disease etc., all available Ermuansou pill for curing.To " lung-heat " coughing of causing, expectorant, disease such as breathe heavily, be main generally in the treatment to remove exopathogen, auxiliary with dispelling wind, cough-relieving, the medicine that reduces phlegm, relieving asthma.
At present, this prescription type is a tablet.Preparation technology is following: the preparation technology of Ermuansou sheet is following in the prior art: Bulbus Lilii, Bulbus Fritillariae Thunbergii pulverize separately become fine powder, sieve; The Rhizoma Anemarrhenae, Pericarpium Papaveris, Radix Scrophulariae, decocte with water Radix Ophiopogonis secondary, 3 hours for the first time, 1 hour for the second time, collecting decoction filtered, and filtrating is condensed into cream; Flos Farfarae, Radix Asteris are extracted secondary with 60% alcohol heating reflux, and 6 hours for the first time, 4 hours for the second time, 2 hours for the third time; Semen Armeniacae Amarum deoils, and extracts secondary with 85% alcohol heating reflux, and 3 hours for the first time, 2 hours for the second time, merge extractive liquid, reclaimed ethanol, is condensed into cream.Above-mentioned two kinds of condensed creams are merged, add fine powder and right amount of auxiliary materials mixings such as Bulbus Lilii, process granule, drying, compacting is in flakes.This preparation technology is complicated, for example Semen Armeniacae Amarum processings of need deoiling earlier, and every weight of the tablet of processing simultaneously 0.6g, four of adhibs of patient, one day twice, dose was bigger.
Summary of the invention
First technical problem that the present invention will solve provides the Chinese medicine composition that a kind of removing heat from the lung and dissipating phlegm antitussive evident in efficacy is relievingd asthma.
Another technical problem that the present invention will solve provides manufacturing method for above mentioned medicine.
For realizing above-mentioned purpose, the present invention adopts following technical scheme:
A kind of Chinese medicine composition of removing heat from the lung and dissipating phlegm relieving cough, relieving asthma, its active component is processed by the raw material of following parts by weight: 108 parts of the Rhizoma Anemarrhenaes, 108 parts of Radix Scrophulariaes, 216 parts of Pericarpium Papaveriss; 108 parts of Radix Ophiopogonis, 324 parts of Flos Farfaraees, 108 parts of Radix Asteriss; 108 parts of Semen Armeniacae Amarums, 108 parts of Bulbus Liliies, 54 parts of Bulbus Fritillariae Thunbergiis.
Said active component adopts following method to prepare: Bulbus Lilii, Bulbus Fritillariae Thunbergii pulverize separately become fine powder, sieve; Add the Rhizoma Anemarrhenae, Pericarpium Papaveris, Radix Scrophulariae, Radix Ophiopogonis 6-14 times of water gaging and decoct 2-3 time, each 1-3 hour, collecting decoction; Being evaporated to 5060 ℃ of condition lower densities is 1.03-1.10, and in concentrated solution, adding concentration of volume percent is the ethanol of 90-98%, and making supernatant ethanol concentration of volume percent is 60-80%; Left standstill 12-36 hour; Filter, get supernatant, being evaporated to 50-60 ℃ of condition lower density is 1.03-1.10; It is 60%80% ethanol percolation that Flos Farfarae, Radix Asteris, Semen Armeniacae Amarum use 10-20 doubly to measure concentration of volume percent, receives percolate, and being evaporated to 50-60 ℃ of condition lower density is 1.03-1.10; Drying under reduced pressure or spray drying behind above water extracting liquid and alcohol extraction concentrated solution adding Bulbus Lilii, the Bulbus Fritillariae Thunbergii fine powder.
Said active component adopts following method to prepare: Bulbus Lilii, Bulbus Fritillariae Thunbergii pulverize separately become fine powder, sieve; Add the Rhizoma Anemarrhenae, Pericarpium Papaveris, Radix Scrophulariae, Radix Ophiopogonis 8-10 times of water gaging and decoct 2-3 time, each 1-3 hour, collecting decoction; Being evaporated to 50-60 ℃ of condition lower density is 1.05-1.08, and in concentrated solution, adding concentration of volume percent is the ethanol of 95-98%, and making supernatant ethanol concentration of volume percent is 60-80%; Left standstill 18-30 hour; Filter, get supernatant, being evaporated to 50-60 ℃ of condition lower density is 1.05-1.08; Flos Farfarae, Radix Asteris, Semen Armeniacae Amarum use 10-20 doubly to measure concentration of volume percent to be the 70%-75% ethanol percolation, receive percolate, and being evaporated to 5060 ℃ of condition lower densities is 1.05-1.08; Drying under reduced pressure or spray drying behind above water extracting liquid and alcohol extraction concentrated solution adding Bulbus Lilii, the Bulbus Fritillariae Thunbergii fine powder.
Said active component adopts following method to prepare: Bulbus Lilii, Bulbus Fritillariae Thunbergii pulverize separately become fine powder, sieve; Add the Rhizoma Anemarrhenae, Pericarpium Papaveris, Radix Scrophulariae, Radix Ophiopogonis 10 times of water gagings and decoct 2 times, each 2 hours, collecting decoction; Being evaporated to 5060 ℃ of condition lower densities is 1.05-1.08, and the adding concentration of volume percent is 95% ethanol in concentrated solution, and making supernatant ethanol concentration of volume percent is 70%; Left standstill 24 hours; Filter, get supernatant, being evaporated to 50-60 ℃ of condition lower density is 1.05-1.08; It is 70% ethanol percolation that Flos Farfarae, Radix Asteris, Semen Armeniacae Amarum use 15 times of amount concentration of volume percent, receives percolate, and being evaporated to 50-60 ℃ of condition lower density is 1.05-1.08; Drying under reduced pressure or spray drying behind above water extracting liquid and alcohol extraction concentrated solution adding Bulbus Lilii, the Bulbus Fritillariae Thunbergii fine powder.
Said pharmaceutical composition also contains the pharmaceutics acceptable auxiliary.
Said pharmaceutics acceptable auxiliary is selected from any one or a few in starch, microcrystalline Cellulose, sucrose, dextrin, lactose, Icing Sugar, glucose, sodium chloride, vitamin C, cysteine, citric acid and the sodium sulfite.
The dosage form of said Chinese medicine composition is pill, tablet, capsule or oral liquid.The selection of dosage form and the consumption of adjuvant all belong to prior art.
A kind of method for preparing of Chinese medicine composition of removing heat from the lung and dissipating phlegm relieving cough, relieving asthma takes by weighing 108 parts of the Rhizoma Anemarrhenaes, 108 parts of Radix Scrophulariaes, 216 parts of Pericarpium Papaveriss, 108 parts of Radix Ophiopogonis, 324 parts of Flos Farfaraees, 108 parts of Radix Asteriss, 108 parts of Semen Armeniacae Amarums, 108 parts of Bulbus Liliies, 54 parts of Bulbus Fritillariae Thunbergiis; Bulbus Lilii, Bulbus Fritillariae Thunbergii pulverize separately become fine powder, sieve; Add the Rhizoma Anemarrhenae, Pericarpium Papaveris, Radix Scrophulariae, Radix Ophiopogonis 6-14 times of water gaging and decoct 2-3 time, each 1-3 hour, collecting decoction; Being evaporated to 50-60 ℃ of condition lower density is 1.03-1.10, and in concentrated solution, adding concentration of volume percent is the ethanol of 90-98%, and making supernatant ethanol concentration of volume percent is 60-80%; Left standstill 12-36 hour; Filter, get supernatant, being evaporated to 50-60 ℃ of condition lower density is 1.03-1.10; Flos Farfarae, Radix Asteris, Semen Armeniacae Amarum use 10-20 doubly to measure concentration of volume percent to be the 60%-80% ethanol percolation, receive percolate, and being evaporated to 50-60 ℃ of condition lower density is 1.03-1.10; Drying under reduced pressure or spray drying behind above water extracting liquid and alcohol extraction concentrated solution adding Bulbus Lilii, the Bulbus Fritillariae Thunbergii fine powder.The paste-forming rate of this technology is: 15-25%.
Said Bulbus Lilii, Bulbus Fritillariae Thunbergii pulverize separately become fine powder, sieve; Add the Rhizoma Anemarrhenae, Pericarpium Papaveris, Radix Scrophulariae, Radix Ophiopogonis 8-10 times of water gaging and decoct 23 times, each 1-3 hour, collecting decoction; Being evaporated to 50-60 ℃ of condition lower density is 1.05-1.08, and in concentrated solution, adding concentration of volume percent is the ethanol of 95-98%, and making supernatant ethanol concentration of volume percent is 60-80%; Left standstill 18-30 hour; Filter, get supernatant, being evaporated to 50-60 ℃ of condition lower density is 1.05-1.08; It is 70%75% ethanol percolation that Flos Farfarae, Radix Asteris, Semen Armeniacae Amarum use 10-20 doubly to measure concentration of volume percent, receives percolate, and being evaporated to 50-60 ℃ of condition lower density is 1.05-1.08; Drying under reduced pressure or spray drying behind above water extracting liquid and alcohol extraction concentrated solution adding Bulbus Lilii, the Bulbus Fritillariae Thunbergii fine powder.
Said Bulbus Lilii, Bulbus Fritillariae Thunbergii pulverize separately become fine powder, sieve; Add the Rhizoma Anemarrhenae, Pericarpium Papaveris, Radix Scrophulariae, Radix Ophiopogonis 10 times of water gagings and decoct 2 times, each 2 hours, collecting decoction; Being evaporated to 50-60 ℃ of condition lower density is 1.05-1.08, and the adding concentration of volume percent is 95% ethanol in concentrated solution, and making supernatant ethanol concentration of volume percent is 70%; Left standstill 24 hours; Filter, get supernatant, being evaporated to 50-60 ℃ of condition lower density is 1.05-1.08; It is 70% ethanol percolation that Flos Farfarae, Radix Asteris, Semen Armeniacae Amarum use 15 times of amount concentration of volume percent, receives percolate, and being evaporated to 50-60 ℃ of condition lower density is 1.05-1.08; Drying under reduced pressure or spray drying behind above water extracting liquid and alcohol extraction concentrated solution adding Bulbus Lilii, the Bulbus Fritillariae Thunbergii fine powder.
A kind of preparation of Chinese medicine composition of clear removing heat from the lung and dissipating phlegm relieving cough, relieving asthma, said preparation adds the pharmaceutics acceptable auxiliary with above-mentioned active constituents of medicine, processes the pharmaceutics acceptable forms.When utilizing the active component of the Chinese medicine composition of the removing heat from the lung and dissipating phlegm relieving cough, relieving asthma that the present invention obtains to prepare the various dosage form of required medicine, can be according to the conventional production method preparation in pharmaceutics field.As this active component mixed with one or more carriers, process corresponding dosage forms then.
Advantage of the present invention is: Chinese medicine composition that technical scheme of the present invention is protected and preparation thereof all have good removing heat from the lung and dissipating phlegm antitussive antiasthmatic effect; Through zoopery; We unexpectedly find; The active constituents of medicine that adopts technical scheme of the present invention to obtain has reduced the cough number of times of laboratory animal significantly, and possesses splendid phlegm-dispelling functions.
Advantage of the present invention is: the present invention uses theory of Chinese medical science analysis prescription to form, and according to the physicochemical property and the Pharmacological action study result of each flavour of a drug ingredient, research has obtained the method for preparing of reasonable, stable active component.Adopt technical scheme of the present invention, prepared pharmaceutical preparation stable and controllable for quality, that curative effect is compared with existing commercially available dosage form and significantly improved, patient's taking dose reduces, have remarkable economical and social benefit.
Below specify technical scheme of the present invention through embodiment, do not limit practical range of the present invention with this.
The specific embodiment
Embodiment 1: the preparation Chinese medicine extract
One. prescription: Rhizoma Anemarrhenae 1.2kg, Radix Scrophulariae 1.2kg, Pericarpium Papaveris 2.4kg, Radix Ophiopogonis 1.2kg, Flos Farfarae 3.6kg, Radix Asteris 1.2kg, Semen Armeniacae Amarum 1.2kg, Bulbus Lilii 1.2kg, Bulbus Fritillariae Thunbergii 0.6kg.
Two. method for making: Bulbus Lilii, Bulbus Fritillariae Thunbergii pulverize separately become fine powder, cross 100 mesh sieves; The Rhizoma Anemarrhenae, Pericarpium Papaveris, Radix Scrophulariae, decocte with water Radix Ophiopogonis 2 times, each 2 hours, 10 times of water gagings; Collecting decoction, being evaporated to density is 1.03-1.10 (5060 ℃), concentrated solution adds 95% ethanol; Making the supernatant concentration of alcohol is 60%, leaves standstill 24 hours, filters; Get supernatant, being evaporated to density is 1.03-1.10 (50-60 ℃); Flos Farfarae, Radix Asteris, Semen Armeniacae Amarum are with 15 times of amounts of 60% ethanol percolation; Receive percolate, be evaporated to density and be the above water of 1.03-1.10 (50-60 ℃) carry with alcohol extraction group concentrated solution adding Bulbus Lilii, Bulbus Fritillariae Thunbergii fine powder after drying under reduced pressure or spray drying get the about 2.4kg of extract powder.
Embodiment 2: the preparation Chinese medicine extract
One. prescription: Rhizoma Anemarrhenae 12kg, Radix Scrophulariae 12kg, Pericarpium Papaveris 24kg, Radix Ophiopogonis 12kg, Flos Farfarae 36kg, Radix Asteris 12kg, Semen Armeniacae Amarum 12kg, Bulbus Lilii 12kg, Bulbus Fritillariae Thunbergii 6kg.
Two. method for making: Bulbus Lilii, Bulbus Fritillariae Thunbergii pulverize separately become fine powder, cross 100 mesh sieves; The Rhizoma Anemarrhenae, Pericarpium Papaveris, Radix Scrophulariae, decocte with water Radix Ophiopogonis 2 times, 2 hours 14 times of water gagings, 2 hours 10 times of water gagings for the second time for the first time; Collecting decoction, being evaporated to density is 1.03-1.10 (50-60 ℃), concentrated solution adds 95% ethanol; Making the supernatant concentration of alcohol is 60%, leaves standstill 24 hours, filters; Get supernatant, being evaporated to density is 1.03-1.10 (50-60 ℃); Flos Farfarae, Radix Asteris, Semen Armeniacae Amarum are with 15 times of amounts of 60% ethanol percolation; Receive percolate, be evaporated to density and be the above water of 1.03-1.10 (50-60 ℃) carry with alcohol extraction group concentrated solution adding Bulbus Lilii, Bulbus Fritillariae Thunbergii fine powder after drying under reduced pressure or spray drying get the about 26.4kg of extract powder.
Embodiment 3: the preparation Chinese medicine extract
One. prescription: Rhizoma Anemarrhenae 1080g, Radix Scrophulariae 1080g, Pericarpium Papaveris 2160g, Radix Ophiopogonis 1080g, Flos Farfarae 3240g, Radix Asteris 1080g, Semen Armeniacae Amarum 1080g, Bulbus Lilii 1080g, Bulbus Fritillariae Thunbergii 540g.
Two. method for making: Bulbus Lilii, Bulbus Fritillariae Thunbergii pulverize separately become fine powder, cross 100 mesh sieves; Add the Rhizoma Anemarrhenae, Pericarpium Papaveris, Radix Scrophulariae, Radix Ophiopogonis 6 times of water gagings and decoct 2 times, each 1 hour, collecting decoction; Being evaporated to 50-60 ℃ of condition lower density is 1.03, and the adding concentration of volume percent is 90% ethanol in concentrated solution, and making supernatant ethanol concentration of volume percent is 60%; Left standstill 12 hours; Filter, get supernatant, being evaporated to 50-60 ℃ of condition lower density is 1.03; It is 60% ethanol percolation that Flos Farfarae, Radix Asteris, Semen Armeniacae Amarum use 10 times of amount concentration of volume percent, receives percolate, and being evaporated to 50-60 ℃ of condition lower density is 1.03; Drying under reduced pressure behind above water extracting liquid and alcohol extraction concentrated solution adding Bulbus Lilii, the Bulbus Fritillariae Thunbergii fine powder gets extract 1920g.
Embodiment 4: the preparation Chinese medicine extract
One. prescription: Rhizoma Anemarrhenae 1080g, Radix Scrophulariae 1080g, Pericarpium Papaveris 2160g, Radix Ophiopogonis 1080g, Flos Farfarae 3240g, Radix Asteris 1080g, Semen Armeniacae Amarum 1080g, Bulbus Lilii 1080g, Bulbus Fritillariae Thunbergii 540g.
Two. method for making: Bulbus Lilii, Bulbus Fritillariae Thunbergii pulverize separately become fine powder, cross 100 mesh sieves; Add the Rhizoma Anemarrhenae, Pericarpium Papaveris, Radix Scrophulariae, Radix Ophiopogonis 14 times of water gagings and decoct 3 times, each 3 hours, collecting decoction; Being evaporated to 50-60 ℃ of condition lower density is 1.10, and the adding concentration of volume percent is 98% ethanol in concentrated solution, and making supernatant ethanol concentration of volume percent is 80%; Left standstill 36 hours; Filter, get supernatant, being evaporated to 50-60 ℃ of condition lower density is 1.10; It is 80% ethanol percolation that Flos Farfarae, Radix Asteris, Semen Armeniacae Amarum use 20 times of amount concentration of volume percent, receives percolate, and being evaporated to 50-60 ℃ of condition lower density is 1.10; Spray drying behind above water extracting liquid and alcohol extraction concentrated solution adding Bulbus Lilii, the Bulbus Fritillariae Thunbergii fine powder gets extract 3085g.
Embodiment 5: the preparation Chinese medicine extract
One. prescription: Rhizoma Anemarrhenae 1080g, Radix Scrophulariae 1080g, Pericarpium Papaveris 2160g, Radix Ophiopogonis 1080g, Flos Farfarae 3240g, Radix Asteris 1080g, Semen Armeniacae Amarum 1080g, Bulbus Lilii 1080g, Bulbus Fritillariae Thunbergii 540g.
Two. method for making: Bulbus Lilii, Bulbus Fritillariae Thunbergii pulverize separately become fine powder, sieve; Add the Rhizoma Anemarrhenae, Pericarpium Papaveris, Radix Scrophulariae, Radix Ophiopogonis 8 times of water gagings and decoct 2 times, each 2 hours, collecting decoction; Being evaporated to 50-60 ℃ of condition lower density is 1.05, and the adding concentration of volume percent is 95% ethanol in concentrated solution, and making supernatant ethanol concentration of volume percent is 60%; Left standstill 18 hours; Filter, get supernatant, being evaporated to 50-60 ℃ of condition lower density is 1.05; It is 70% ethanol percolation that Flos Farfarae, Radix Asteris, Semen Armeniacae Amarum use 10 times of amount concentration of volume percent, receives percolate, and being evaporated to 50-60 ℃ of condition lower density is 1.05; Drying under reduced pressure or spray drying behind above water extracting liquid and alcohol extraction concentrated solution adding Bulbus Lilii, the Bulbus Fritillariae Thunbergii fine powder get extract 2378g.
Embodiment 6: the preparation Chinese medicine extract
One. prescription: Rhizoma Anemarrhenae 1080g, Radix Scrophulariae 1080g, Pericarpium Papaveris 2160g, Radix Ophiopogonis 1080g, Flos Farfarae 3240g, Radix Asteris 1080g, Semen Armeniacae Amarum 1080g, Bulbus Lilii 1080g, Bulbus Fritillariae Thunbergii 540g.
Two. method for making: Bulbus Lilii, Bulbus Fritillariae Thunbergii pulverize separately become fine powder, sieve; Add the Rhizoma Anemarrhenae, Pericarpium Papaveris, Radix Scrophulariae, Radix Ophiopogonis 10 times of water gagings and decoct 2 times, each 1.5 hours, collecting decoction; Being evaporated to 50-60 ℃ of condition lower density is 1.08, and the adding concentration of volume percent is 98% ethanol in concentrated solution, and making supernatant ethanol concentration of volume percent is 80%; Left standstill 30 hours; Filter, get supernatant, being evaporated to 50-60 ℃ of condition lower density is 1.08; It is 75% ethanol percolation that Flos Farfarae, Radix Asteris, Semen Armeniacae Amarum use 20 times of amount concentration of volume percent, receives percolate, and being evaporated to 50-60 ℃ of condition lower density is 1.08; Drying under reduced pressure or spray drying behind above water extracting liquid and alcohol extraction concentrated solution adding Bulbus Lilii, the Bulbus Fritillariae Thunbergii fine powder get extract 2832g.
Embodiment 7: the preparation Chinese medicine extract
One. prescription: Rhizoma Anemarrhenae 1080g, Radix Scrophulariae 1080g, Pericarpium Papaveris 2160g, Radix Ophiopogonis 1080g, Flos Farfarae 3240g, Radix Asteris 1080g, Semen Armeniacae Amarum 1080g, Bulbus Lilii 1080g, Bulbus Fritillariae Thunbergii 540g.
Two. method for making: Bulbus Lilii, Bulbus Fritillariae Thunbergii pulverize separately become fine powder, sieve; Add the Rhizoma Anemarrhenae, Pericarpium Papaveris, Radix Scrophulariae, Radix Ophiopogonis 10 times of water gagings and decoct 2 times, each 2 hours, collecting decoction; Being evaporated to 50-60 ℃ of condition lower density is 1.06, and the adding concentration of volume percent is 95% ethanol in concentrated solution, and making supernatant ethanol concentration of volume percent is 70%; Left standstill 24 hours; Filter, get supernatant, being evaporated to 50-60 ℃ of condition lower density is 1.06; It is 70% ethanol percolation that Flos Farfarae, Radix Asteris, Semen Armeniacae Amarum use 15 times of amount concentration of volume percent, receives percolate, and being evaporated to 50-60 ℃ of condition lower density is 1.06; Drying under reduced pressure or spray drying behind above water extracting liquid and alcohol extraction concentrated solution adding Bulbus Lilii, the Bulbus Fritillariae Thunbergii fine powder get extract 2932g.
Embodiment 8: the preparation capsule
Get drug extract (active component) 100g that embodiment 1 prepares, add starch 15g, Pulvis Talci 1g uses 80% alcohol granulation, the fill capsule.Every is 0.18g.
Embodiment 9: the preparation tablet
Get drug extract (active component) 100g that embodiment 3 prepares, add starch 10g, cross-linked pvp 5g, tabletting gets tablet, and every is 0.45g.
Embodiment 10: zoopery one
One. material and method:
Ermuansou ball (lot number 090201), reaching core hall pharmaceutical factory by new Pharmaceutical limited company in the Tianjin provides.
Ermuansou sheet (lot number: 081025), provide along banyan pharmaceutical factory by new Pharmaceutical limited company is grand in the Tianjin.
Ermuansou syrup (lot number: 080301), provide along banyan development pharmaceutical Co. Ltd by Tianjin is grand.
Animal: the ICR mice, 18-22g is provided by Beijing Vital River Experimental Animals Technology Co., Ltd., credit number: SCXK (capital) 2002-0003.
FUFANG GANCAO PIAN (lot number 090215): Tianjin Lisheng Pharmaceutical Co., Ltd.
Anhydrous sodium sulfite (lot number H06532): Guangzhou Chemical Reagent Factory
Sulphuric acid (lot number X2567): Tianjin chemical reagent one factory
Get 112 of healthy ICR mices, divide 7 groups at random, labelling is got embodiment 1 gained active component, is made into the extract dosage respectively and is equivalent to 4.5g crude drug/kg and 9.0g crude drug/kg.Get Ermuansou ball, Ermuansou sheet and Ermuansou syrup and all be made into dosage and be equivalent to 4.5g crude drug/kg and irritate stomach, successive administration 5 days, the positive drug FUFANG GANCAO PIAN is in experiment administration on the same day 1 time.Each organizes after the last administration 1 hour, gets the 25ml glass dish, adds 0.5g anhydrous sodium sulfite and 50% sulphuric acid 5ml; Fasten glass dish with the 500ml bell jar; Rapidly mice is put into the bell jar that contains sulfur dioxide, (it is that the mice abdominal muscle shrinks that the typical case coughs to cough number of times in cough latent period of observation and record mice and the 2min, magnifies mouth simultaneously; With coughing sound), experimental data is added up with variance analysis.
Two. the result: the result sees table one.
The result shows: the cough latent period of Ermuansou extract high dose group has utmost point significant difference with the model control group ratio, and other each administration groups all have significant difference with the model control group ratio.Extract is low, the number of times of cough in the high dose group 2 minutes and model control group be than P＜0.01, and utmost point significant difference is arranged.The number of times of cough and model control group have significant difference than P＜0.05 in the sheet, ball, the former dosage form group of syrup 2 minutes.Prompting is under 9.0g/kg dosage, and the Ermuansou extract can obviously prolong the inductive mouse cough of sulfur dioxide incubation period, reduces the cough number of times.Under 4.5g/kg dosage, the Ermuansou extract can obviously reduce the cough number of times of sulfur dioxide inducing mouse, and it compares P＜0.05 with sheet, ball, each former dosage form of syrup, and significant difference is arranged.Point out Ermuansou extract of the present invention that antitussive effect is arranged, and curative effect is superior to former dosage form.
Table one: the Ermuansou extract administration influence to sulfur dioxide initiation mouse cough in five days (x ± s)
Compare with model control group,
*P＜0.05,
*P＜0.01; Compare #P＜0.05 with ball, sheet, the former dosage form group of syrup
Embodiment 5: zoopery two
One. material and method:
Ermuansou ball (lot number 090201), reaching core hall pharmaceutical factory by new Pharmaceutical limited company in the Tianjin provides.
Ermuansou sheet (lot number: 081002), provide along banyan pharmaceutical factory by new Pharmaceutical limited company is grand in the Tianjin.
Ermuansou syrup (lot number: 081205) provide along banyan development pharmaceutical Co. Ltd by Tianjin is grand.
Animal: Cavia porcellus, 180-200g, male and female half and half provide credit number by the flourish holy pool breed resultant field of practicing in Shanghai: SCXK (Shanghai) 20020012.
Ammonium chloride (lot number: 081035): dragon Xinghua, Asia-Pacific, Tianjin worker's company limited
Phenol red (lot number: 081127): rich Dihua, Tianjin worker's company limited instrument
UV7504 ultraviolet-uisible spectrophotometer: Shanghai precision instrument company limited
Get 84 of healthy 1CR mices, divide 7 groups at random, labelling is got embodiment 2 gained active component, is made into the extract dosage respectively and is equivalent to 4.5g crude drug/kg and 9.0g crude drug/kg.Get Ermuansou ball, Ermuansou sheet and Ermuansou syrup and all be made into dosage and be equivalent to 4.5g crude drug/kg and irritate stomach, successive administration 5 days, in administration after the 4th day, mice fasting 12 hours.0.5 hour lumbar injection 5% phenol red normal saline solution 10ml/kg after the last administration; 0.5 disconnected neck is put to death mice after hour; Cut from one section trachea of thyroid cartilage to trachea bifurcation, put into the test tube that fills alkaline normal saline (normal saline 2ml+1N sodium hydroxide 0.1m1) solution, after room temperature is placed 2 hours; The trachea eluent is surveyed its absorbance with ultraviolet-uisible spectrophotometer in the 546nm wavelength, calculate every phenol red content of mice trachea through phenol red standard curve.Experimental data is added up with variance analysis.
Two. the result: the result sees table two.
Table two: the Ermuansou extract administration influence to the mice phlegm-dispelling functions in five days (x ± s)
Compare with the blank group
*P＜0.05,
*P＜0.01
The result shows: Ermuansou extract high dose group and blank group be P＜0.01 relatively; Utmost point significant difference is arranged; Extract low dose group and blank group be P＜0.05 relatively, and significant difference is arranged, and points out this extract can obviously promote the phenol red excretion amount of mice trachea; And present certain dose-effect relationship, explain that this invention extract has good phlegm-dispelling functions.Under 4.5g/kg dosage, Ermuansou extract and each former dosage form relatively have the trend that is superior to former dosage form phlegm-dispelling functions, and the few advantage of dose are arranged.
Claims (8)
1. the Chinese medicine composition of a removing heat from the lung and dissipating phlegm relieving cough, relieving asthma, it is characterized in that: its active component is processed by the raw material of following parts by weight: 108 parts of the Rhizoma Anemarrhenaes, 108 parts of Radix Scrophulariaes; 216 parts of Pericarpium Papaveriss, 108 parts of Radix Ophiopogonis, 324 parts of Flos Farfaraees; 108 parts of Radix Asteriss; 108 parts of Semen Armeniacae Amarums, 108 parts of Bulbus Liliies, 54 parts of Bulbus Fritillariae Thunbergiis; Said active component adopts following method to prepare: Bulbus Lilii, Bulbus Fritillariae Thunbergii pulverize separately become fine powder, sieve; Add the Rhizoma Anemarrhenae, Pericarpium Papaveris, Radix Scrophulariae, Radix Ophiopogonis 6-14 times of water gaging and decoct 2-3 time, each 1-3 hour, collecting decoction; Being evaporated to 50-60 ℃ of condition lower density is 1.03-1.10, and in concentrated solution, adding concentration of volume percent is the ethanol of 90-98%, and making supernatant ethanol concentration of volume percent is 60-80%; Left standstill 12-36 hour; Filter, get supernatant, being evaporated to 50-60 ℃ of condition lower density is 1.03-1.10; Flos Farfarae, Radix Asteris, Semen Armeniacae Amarum use 10-20 doubly to measure concentration of volume percent to be the 60%-80% ethanol percolation, receive percolate, and being evaporated to 50-60 ℃ of condition lower density is 1.03-1.10; Drying under reduced pressure or spray drying behind above water extracting liquid and alcohol extraction concentrated solution adding Bulbus Lilii, the Bulbus Fritillariae Thunbergii fine powder.
2. the Chinese medicine composition of a kind of removing heat from the lung and dissipating phlegm relieving cough, relieving asthma according to claim 1 is characterized in that: said active component adopts following method to prepare: Bulbus Lilii, Bulbus Fritillariae Thunbergii pulverize separately become fine powder, sieve; Add the Rhizoma Anemarrhenae, Pericarpium Papaveris, Radix Scrophulariae, Radix Ophiopogonis 8-10 times of water gaging and decoct 2-3 time, each 1-3 hour, collecting decoction; Being evaporated to 50-60 ℃ of condition lower density is 1.05-1.08, and in concentrated solution, adding concentration of volume percent is the ethanol of 95-98%, and making supernatant ethanol concentration of volume percent is 60-80%; Left standstill 18-30 hour; Filter, get supernatant, being evaporated to 50-60 ℃ of condition lower density is 1.05-1.08; Flos Farfarae, Radix Asteris, Semen Armeniacae Amarum use 10-20 doubly to measure concentration of volume percent to be the 70%-75% ethanol percolation, receive percolate, and being evaporated to 50-60 ℃ of condition lower density is 1.05-1.08; Drying under reduced pressure or spray drying behind above water extracting liquid and alcohol extraction concentrated solution adding Bulbus Lilii, the Bulbus Fritillariae Thunbergii fine powder.
3. the Chinese medicine composition of a kind of removing heat from the lung and dissipating phlegm relieving cough, relieving asthma according to claim 2 is characterized in that: said active component adopts following method to prepare: Bulbus Lilii, Bulbus Fritillariae Thunbergii pulverize separately become fine powder, sieve; Add the Rhizoma Anemarrhenae, Pericarpium Papaveris, Radix Scrophulariae, Radix Ophiopogonis 10 times of water gagings and decoct 2 times, each 2 hours, collecting decoction; Being evaporated to 50-60 ℃ of condition lower density is 1.05-1.08, and the adding concentration of volume percent is 95% ethanol in concentrated solution, and making supernatant ethanol concentration of volume percent is 70%; Left standstill 24 hours; Filter, get supernatant, being evaporated to 50-60 ℃ of condition lower density is 1.05-1.08; It is 70% ethanol percolation that Flos Farfarae, Radix Asteris, Semen Armeniacae Amarum use 15 times of amount concentration of volume percent, receives percolate, and being evaporated to 50-60 ℃ of condition lower density is 1.05-1.08; Drying under reduced pressure or spray drying behind above water extracting liquid and alcohol extraction concentrated solution adding Bulbus Lilii, the Bulbus Fritillariae Thunbergii fine powder.
4. according to the Chinese medicine composition of any one described a kind of removing heat from the lung and dissipating phlegm relieving cough, relieving asthma in the claim 1 to 3, it is characterized in that: said pharmaceutics acceptable auxiliary is selected from any one or a few in starch, microcrystalline Cellulose, sucrose, dextrin, lactose, Icing Sugar, glucose, sodium chloride, vitamin C, cysteine, citric acid and the sodium sulfite.
5. the Chinese medicine composition of a kind of removing heat from the lung and dissipating phlegm relieving cough, relieving asthma according to claim 4 is characterized in that: the dosage form of said Chinese medicine composition is pill, tablet, capsule or oral liquid.
6. the method for preparing of the Chinese medicine composition of the described a kind of removing heat from the lung and dissipating phlegm relieving cough, relieving asthma of claim 1 is characterized in that: take by weighing 108 parts of the Rhizoma Anemarrhenaes, 108 parts of Radix Scrophulariaes, 216 parts of Pericarpium Papaveriss; 108 parts of Radix Ophiopogonis, 324 parts of Flos Farfaraees, 108 parts of Radix Asteriss; 108 parts of Semen Armeniacae Amarums, 108 parts of Bulbus Liliies, 54 parts of Bulbus Fritillariae Thunbergiis; Bulbus Lilii, Bulbus Fritillariae Thunbergii pulverize separately become fine powder, sieve; Add the Rhizoma Anemarrhenae, Pericarpium Papaveris, Radix Scrophulariae, Radix Ophiopogonis 6-14 times of water gaging and decoct 2-3 time, each 1-3 hour, collecting decoction; Being evaporated to 50-60 ℃ of condition lower density is 1.03-1.10, and in concentrated solution, adding concentration of volume percent is the ethanol of 90-98%, and making supernatant ethanol concentration of volume percent is 60-80%; Left standstill 12-36 hour; Filter, get supernatant, being evaporated to 50-60 ℃ of condition lower density is 1.03-1.10; Flos Farfarae, Radix Asteris, Semen Armeniacae Amarum use 10-20 doubly to measure concentration of volume percent to be the 60%-80% ethanol percolation, receive percolate, and being evaporated to 50-60 ℃ of condition lower density is 1.03-1.10; Drying under reduced pressure or spray drying behind above water extracting liquid and alcohol extraction concentrated solution adding Bulbus Lilii, the Bulbus Fritillariae Thunbergii fine powder.
7. the method for preparing of the Chinese medicine composition of a kind of removing heat from the lung and dissipating phlegm relieving cough, relieving asthma according to claim 6 is characterized in that: said Bulbus Lilii, Bulbus Fritillariae Thunbergii pulverize separately become fine powder, sieve; Add the Rhizoma Anemarrhenae, Pericarpium Papaveris, Radix Scrophulariae, Radix Ophiopogonis 8-10 times of water gaging and decoct 2-3 time, each 1-3 hour, collecting decoction; Being evaporated to 50-60 ℃ of condition lower density is 1.05-1.08, and in concentrated solution, adding concentration of volume percent is the ethanol of 95-98%, and making supernatant ethanol concentration of volume percent is 60-80%; Left standstill 18-30 hour; Filter, get supernatant, being evaporated to 50-60 ℃ of condition lower density is 1.05-1.08; Flos Farfarae, Radix Asteris, Semen Armeniacae Amarum use 10-20 doubly to measure concentration of volume percent to be the 70%-75% ethanol percolation, receive percolate, and being evaporated to 50-60 ℃ of condition lower density is 1.05-1.08; Drying under reduced pressure or spray drying behind above water extracting liquid and alcohol extraction concentrated solution adding Bulbus Lilii, the Bulbus Fritillariae Thunbergii fine powder.
8. the method for preparing of the Chinese medicine composition of a kind of removing heat from the lung and dissipating phlegm relieving cough, relieving asthma according to claim 6 is characterized in that: said Bulbus Lilii, Bulbus Fritillariae Thunbergii pulverize separately become fine powder, sieve; Add the Rhizoma Anemarrhenae, Pericarpium Papaveris, Radix Scrophulariae, Radix Ophiopogonis 10 times of water gagings and decoct 2 times, each 2 hours, collecting decoction; Being evaporated to 50-60 ℃ of condition lower density is 1.05-1.08, and the adding concentration of volume percent is 95% ethanol in concentrated solution, and making supernatant ethanol concentration of volume percent is 70%; Left standstill 24 hours; Filter, get supernatant, being evaporated to 50-60 ℃ of condition lower density is 1.05-1.08; It is 70% ethanol percolation that Flos Farfarae, Radix Asteris, Semen Armeniacae Amarum use 15 times of amount concentration of volume percent, receives percolate, and being evaporated to 50-60 ℃ of condition lower density is 1.05-1.08; Drying under reduced pressure or spray drying behind above water extracting liquid and alcohol extraction concentrated solution adding Bulbus Lilii, the Bulbus Fritillariae Thunbergii fine powder.
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