CN102485256B - Chinese medicine composition for diffusing lung, depressing qi, clearing heat, and eliminating phlegm and preparation method thereof - Google Patents
Chinese medicine composition for diffusing lung, depressing qi, clearing heat, and eliminating phlegm and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a Chinese medicine composition for diffusing lung, depressing qi, clearing heat, and eliminating phlegm and a preparation method thereof, belonging to the field of traditional Chinese medicine modernization. The active components of the Chinese medicine composition comprise 0.34 weight parts of menthol crystal, 45 weight parts of bulbus fritillariae ussuriensis, 45 weight parts of platycodon grandiflorum, 45 weight parts of rhizoma pinelliae praeparatum, and 300 weight parts of folium eriobotryae. The Chinese medicinal composition disclosed herein has stable and controllable quality, higher curative effect than present commercially available dosage forms, and has outstanding economic and social benefits.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition and preparation method and preparation method of dispersing and descending lung-QI removing heat-phlegm, belong to modern Chinese traditional medicine field.
Background technology
Cough is the multiple diseases that a kind of coverage rate is wide, harm is larger.Because the cough that flu and bronchitis cause reaches more than several hundred million person-times every year.According to the statistics made by the departments concerned, the frequency of China's flu is: the adult suffers from 3～4 times every year approximately, and children's suffers from 6 every year approximately, and annual morbidity sum is more than billions of person-times.The characteristics of cough are airway obstruction or hypersecretion, when respiratory tract seriously blocks, and patient's complication such as acutely might causing pulmonary heart disease of coughing, the serious harm patient's is healthy, affects people's quality of life.
In the cough-relieving medicine of selling on the market, no matter Chinese medicine, Western medicine mostly are greatly the dosage forms such as syrup, Tablet and Capsula agent, exist sugar content height, dosage large, take and carry inconvenience and certain shortcomings such as toxic and side effects are arranged.
Controlling and coughing tendril-leaved fritillary bulb loquat drop pills is present commercially available a kind of dispersing and descending lung-QI, the Chinese medicine of removing heat-phlegm, and prescription is comprised of the 5 flavor medicines such as Bulbus Fritillariae Uninbracteatae, Radix Platycodonis, Folium Eriobotryae, Rhizoma pinelliae cordatae, Herba Menthae, it is cough caused to be used for expectorant heat stagnation lung, symptoms including cough, cough up phlegm, dry pharynx, pharyngalgia, heating, general malaise; Flu and bronchitis are seen above-mentioned disease person.Control and cough Bulbus Fritillariae Cirrhosae and criticize Therapeutic Principle drop pill, with moistening lung and cleaning lung, expelling phlegm for arresting cough is method.Control and cough Bulbus Fritillariae Cirrhosae and criticize a pill prescription Folium Eriobotryae, Radix Platycodonis, Rhizoma pinelliae cordatae, Bulbus Fritillariae Ussuriensis, Mentholum 5 flavors and form.In the side take Folium Eriobotryae as monarch drug.The Folium Eriobotryae bitter in the mouth is cold in nature, and delicate fragrance is not dry, can lung moistening relieve inflammation or internal heat, and lowering the adverse-rising QI to resolve phlegm, cough-relieving is coughed surely.Get its lung heat clearing away, sputum eliminating, the merit of making lung-QI pure and descending is to control the disease of expectorant heat stagnation lung.
The present invention uses the R﹠D of modern TCM method, prior art is improved, in the hope of obtaining better curative effect.
Summary of the invention
First technical problem that the present invention will solve provides a kind of Chinese medicine composition of dispersing and descending lung-QI removing heat-phlegm.
Another technical problem that the present invention will solve provides the preparation method of said medicine.
For achieving the above object, the present invention is by the following technical solutions:
A kind of Chinese medicine composition of dispersing and descending lung-QI removing heat-phlegm, its active component is made by the raw material of following parts by weight: 0.34 part of Mentholum, 45 parts of Bulbus Fritillariae Ussuriensiss, 45 parts of Radix Platycodoniss, 45 parts of Rhizoma Pinelliae Preparatum, 300 parts of Folium Eriobotryaes.
Described active component adopts following method to prepare: take by weighing each raw material by proportioning raw materials; Bulbus Fritillariae Ussuriensis is pulverized, and gets fine powder A; The water extraction that Folium Eriobotryae, Radix Platycodonis, Rhizoma pinelliae cordatae are doubly measured with 6-12 2-3 time, each 1-3 hour, be concentrated into that relative density is 1.03-1.10 under the 50-60 ℃ of condition, obtain concentrated solution B; Mentholum and concentrated solution B are merged, and drying obtains dry thing I; Fine powder A and dry thing I are merged, obtain dry thing II, and get final product.Dry thing II is the active component of medicine of the present invention.
Describedly take by weighing each raw material by proportioning raw materials; Bulbus Fritillariae Ussuriensis is pulverized, and gets fine powder A; The water extraction that Folium Eriobotryae, Radix Platycodonis, Rhizoma pinelliae cordatae are doubly measured with 8-10 2-3 time, each 1-2 hour, be concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, obtain concentrated solution B; Mentholum and concentrated solution B are merged, and drying obtains dry thing I; Fine powder A and dry thing I are merged, obtain dry thing II.
Describedly take by weighing each raw material by proportioning raw materials; Bulbus Fritillariae Ussuriensis is pulverized, and gets fine powder A; Folium Eriobotryae, Radix Platycodonis, Rhizoma pinelliae cordatae be with the water extraction of 10 times of amounts 2 times, and each 2 hours, be concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, obtain concentrated solution B; Mentholum and concentrated solution B are merged, and drying obtains dry thing I; Fine powder A and dry thing I are merged, obtain dry thing II.
Described pharmaceutical composition also contains the acceptable adjuvant of pharmaceutics.
The acceptable adjuvant of described pharmaceutics is selected from any one or a few in starch, microcrystalline Cellulose, sucrose, aspartame, dextrin, lactose, Icing Sugar, glucose, sodium chloride, sodium carboxymethyl cellulose, crospolyvinylpyrrolidone, magnesium stearate, micropowder silica gel, vitamin C, cysteine, citric acid and the sodium sulfite.
The dosage form of described Chinese medicine composition is peroral dosage form, includes but not limited to pill, tablet, capsule or oral liquid.The selection of dosage form and the consumption of adjuvant all belong to prior art.
A kind of preparation method of Chinese medicine composition of dispersing and descending lung-QI removing heat-phlegm takes by weighing 0.34 part of Mentholum, 45 parts of Bulbus Fritillariae Ussuriensiss, 45 parts of Radix Platycodoniss, 45 parts of Rhizoma Pinelliae Preparatum, 300 parts of Folium Eriobotryaes; Bulbus Fritillariae Ussuriensis is pulverized, and gets fine powder A; The water extraction that Folium Eriobotryae, Radix Platycodonis, Rhizoma pinelliae cordatae are doubly measured with 6-12 2-3 time, each 1-3 hour, be concentrated into that relative density is 1.03-1.10 under the 50-60 ℃ of condition, obtain concentrated solution B; Mentholum and concentrated solution B are merged, and drying obtains dry thing I; Fine powder A and dry thing I are merged, obtain dry thing II.
Preferred preparation method is: take by weighing each raw material by proportioning raw materials; Bulbus Fritillariae Ussuriensis is pulverized, and gets fine powder A; The water extraction that Folium Eriobotryae, Radix Platycodonis, Rhizoma pinelliae cordatae are doubly measured with 8-10 2-3 time, each 1-2 hour, be concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, obtain concentrated solution B; Mentholum and concentrated solution B are merged, and drying obtains dry thing I; Fine powder A and dry thing I are merged, obtain dry thing II.
Most preferred preparation method is: take by weighing each raw material by proportioning raw materials; Bulbus Fritillariae Ussuriensis is pulverized, and gets fine powder A; Folium Eriobotryae, Radix Platycodonis, Rhizoma pinelliae cordatae be with the water extraction of 10 times of amounts 2 times, and each 2 hours, be concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, obtain concentrated solution B; Mentholum and concentrated solution B are merged, and drying obtains dry thing I; Fine powder A and dry thing I are merged, obtain dry thing II.
The Chinese medicine composition that technical solution of the present invention is related and preparation thereof all have good dispersing and descending lung-QI, removing heat-phlegm effect, and it is cough caused to be used for expectorant heat stagnation lung, symptoms including cough, cough up phlegm, dry pharynx, pharyngalgia, heating, general malaise; Flu and bronchitis are seen above-mentioned disease person.By zoopery, we find that unexpectedly the pharmaceutical composition of technique preparation of the present invention is compared with former dosage form, has excellent antitussive and antiinflammatory action.
Advantage of the present invention is: the present invention uses theory of Chinese medical science analysis prescription to form, and according to the physicochemical property of each flavour of a drug ingredient and the result of study of pharmacological action, research has obtained the preparation method of reasonable, stable active component.Adopt technical solution of the present invention, prepared stable and controllable for quality, curative effect and compared the pharmaceutical preparation that significantly improves with existing commercially available dosage form, have significant economic and social benefit.
Describe by the following examples technical solution of the present invention in detail, do not limit practical range of the present invention with this.
The specific embodiment
Embodiment 1: the preparation Chinese medicine extract
One. prescription: Mentholum 0.34g, Bulbus Fritillariae Ussuriensis 45g, Radix Platycodonis 45g, Rhizoma Pinelliae Preparatum 45g, Folium Eriobotryae 300g.
Two. method for making:
Take by weighing each raw material by proportioning raw materials; Bulbus Fritillariae Ussuriensis is pulverized, and gets fine powder A; Folium Eriobotryae, Radix Platycodonis, Rhizoma pinelliae cordatae be with the water extraction of 10 times of amounts 2 times, and each 2 hours, be concentrated into that relative density is 1.05 under the 50-60 ℃ of condition, obtain concentrated solution B; Mentholum and concentrated solution B are merged, and drying obtains dry thing I; Fine powder A and dry thing I are merged, obtain dry thing II, be the active component of medicine of the present invention.
Embodiment 2: the preparation Chinese medicine extract
One. prescription: Mentholum 0.34g, Bulbus Fritillariae Ussuriensis 45g, Radix Platycodonis 45g, Rhizoma Pinelliae Preparatum 45g, Folium Eriobotryae 300g.
Two. method for making:
Take by weighing each raw material by proportioning raw materials; Bulbus Fritillariae Ussuriensis is pulverized, and gets fine powder A; Folium Eriobotryae, Radix Platycodonis, Rhizoma pinelliae cordatae be with the water extraction of 8 times of amounts 2 times, and each 1.5 hours, be concentrated into that relative density is 1.03 under the 50-60 ℃ of condition, obtain concentrated solution B; Mentholum and concentrated solution B are merged, and drying obtains dry thing I; Fine powder A and dry thing I are merged, obtain dry thing II, be the active component of medicine of the present invention.
Embodiment 3: the preparation Chinese medicine extract
One. prescription: Mentholum 0.34g, Bulbus Fritillariae Ussuriensis 45g, Radix Platycodonis 45g, Rhizoma Pinelliae Preparatum 45g, Folium Eriobotryae 300g.
Two. method for making:
Take by weighing each raw material by proportioning raw materials; Bulbus Fritillariae Ussuriensis is pulverized, and gets fine powder A; Folium Eriobotryae, Radix Platycodonis, Rhizoma pinelliae cordatae be with the water extraction of 10 times of amounts 2 times, and each 2 hours, be concentrated into that relative density is 1.05 under the 50-60 ℃ of condition, obtain concentrated solution B; Mentholum and concentrated solution B are merged, and drying obtains dry thing I; Fine powder A and dry thing I are merged, obtain dry thing II, be the active component of medicine of the present invention.
Embodiment 4: the preparation Chinese medicine extract
One. prescription: Mentholum 0.34g, Bulbus Fritillariae Ussuriensis 45g, Radix Platycodonis 45g, Rhizoma Pinelliae Preparatum 45g, Folium Eriobotryae 300g.
Two. method for making:
Take by weighing each raw material by proportioning raw materials; Bulbus Fritillariae Ussuriensis is pulverized, and gets fine powder A; Folium Eriobotryae, Radix Platycodonis, Rhizoma pinelliae cordatae be with the water extraction of 6 times of amounts 3 times, and each 3 hours, be concentrated into that relative density is 1.08 under the 50-60 ℃ of condition, obtain concentrated solution B; Mentholum and concentrated solution B are merged, and drying obtains dry thing I; Fine powder A and dry thing I are merged, obtain dry thing II, be the active component of medicine of the present invention.
Embodiment 5: the preparation Chinese medicine extract
One. prescription: Mentholum 0.34g, Bulbus Fritillariae Ussuriensis 45g, Radix Platycodonis 45g, Rhizoma Pinelliae Preparatum 45g, Folium Eriobotryae 300g.
Two. method for making:
Take by weighing each raw material by proportioning raw materials; Bulbus Fritillariae Ussuriensis is pulverized, and gets fine powder A; Folium Eriobotryae, Radix Platycodonis, Rhizoma pinelliae cordatae be with the water extraction of 12 times of amounts 3 times, and each 1 hour, be concentrated into that relative density is 1.06 under the 50-60 ℃ of condition, obtain concentrated solution B; Mentholum and concentrated solution B are merged, and drying obtains dry thing I; Fine powder A and dry thing I are merged, obtain dry thing II, be the active component of medicine of the present invention.
Embodiment 6: the preparation Chinese medicine extract
One. prescription: Mentholum 0.34g, Bulbus Fritillariae Ussuriensis 45g, Radix Platycodonis 45g, Rhizoma Pinelliae Preparatum 45g, Folium Eriobotryae 300g.
Two. method for making:
Take by weighing each raw material by proportioning raw materials; Bulbus Fritillariae Ussuriensis is pulverized, and gets fine powder A; Folium Eriobotryae, Radix Platycodonis, Rhizoma pinelliae cordatae be with the water extraction of 10 times of amounts 2 times, and each 2.5 hours, be concentrated into that relative density is 1.10 under the 50-60 ℃ of condition, obtain concentrated solution B; Mentholum and concentrated solution B are merged, and drying obtains dry thing I; Fine powder A and dry thing I are merged, obtain dry thing II, be the active component of medicine of the present invention.
Embodiment 7: the preparation Chinese medicine extract
One. prescription: Mentholum 0.34g, Bulbus Fritillariae Ussuriensis 45g, Radix Platycodonis 45g, Rhizoma Pinelliae Preparatum 45g, Folium Eriobotryae 300g.
Two. method for making:
Take by weighing each raw material by proportioning raw materials; Bulbus Fritillariae Ussuriensis is pulverized, and gets fine powder A; Folium Eriobotryae, Radix Platycodonis, Rhizoma pinelliae cordatae be with the water extraction of 8 times of amounts 3 times, and each 2 hours, be concentrated into that relative density is 1.07 under the 50-60 ℃ of condition, obtain concentrated solution B; Mentholum and concentrated solution B are merged, and drying obtains dry thing I; Fine powder A and dry thing I are merged, obtain dry thing II, be the active component of medicine of the present invention.
Embodiment 8: the preparation capsule
The active component 500g that embodiment 1 method obtains adds dextrin 100g, microcrystalline Cellulose 100g, and the encapsulating capsule gets capsule, and every is 0.45g.
Embodiment 9: the preparation tablet
The active component 100g that embodiment 2 methods obtain adds starch 10g, microcrystalline Cellulose 10g, and sodium carboxymethyl cellulose 1g, tabletting gets tablet, and every is 0.30g.
Embodiment 10: extract of the present invention causes the impact of mouse cough on sulfur dioxide
One. materials and methods
Control and cough tendril-leaved fritillary bulb loquat drop pills, control and cough fritillary-loquat extract (pressing the preparation of embodiment 3 methods), produced by No.6 Chinese Medicine Factory, Tianjin Zhongxin Pharmaceutical Industry Group Co.
Animal: the ICR mice, 18-22g is provided by Beijing Vital River Experimental Animals Technology Co., Ltd., credit number: SCXK (capital) 2002-0003.
Codeine phosphate: Qinghai Pharmaceutic Plant's company limited is produced.
Anhydrous sodium sulfite: Guangzhou Chemical Reagent Factory
Sulphuric acid: Tianjin chemical reagent one factory
Get 80 of healthy ICR mices, body weight 18～22g, be divided at random 5 groups, i.e. blank group, codeine phosphate positive controls (0.06g/kg), control and cough that the fritillary-loquat extract is low, high dose group (1.5,3.0g crude drug/kg), control and cough tendril-leaved fritillary bulb loquat drop pills group (1.5g crude drug/kg), except the blank group gave isopyknic pure water, all by the continuous gastric infusion of above-mentioned dosage 5 days, the administration volume was 20ml/kg to other administration groups.Each organizes after the last administration 1 hour, the evaporating dish that fills the 0.5g anhydrous sodium sulfite is placed in the exsiccator of 500ml, splash into rapidly 50% sulphuric acid 5ml, immediately mice is put into the exsiccator that contains sulfur dioxide gas, (it is that the mice abdominal muscle shrinks that the typical case coughs to cough number of times in the cough latent period of observation and record mice and the 2min, magnify simultaneously mouth, with coughing sound), experimental data is added up with variance analysis.
Two. result: see Table 1.
Table 1 is controlled and is coughed the fritillary-loquat extract causes mouse cough on sulfur dioxide impact
Compare * P＜0.05, * * P＜0.01 with the blank group; Cough the tendril-leaved fritillary bulb loquat drop pills group and compare #P＜0.05 with controlling
The result shows: control and cough that the fritillary-loquat extract is low, in the cough latent period of high dose group and the 2min cough number of times and blank group than significant difference (P＜0.05 is all arranged, P＜0.01), point out extract of the present invention can obviously prolong the mouse cough incubation period that sulfur dioxide is induced, reduce the cough number of times.Under Isodose dosage, control and cough the fritillary-loquat extract and cough the tendril-leaved fritillary bulb loquat drop pills ratio significant difference (P＜0.05) is arranged with controlling.Prompting the present invention controls and coughs the fritillary-loquat extract antitussive effect is arranged, and curative effect is better than former dosage form.
Embodiment 11: extract xylol of the present invention causes the impact of mice auricle swelling
One. materials and methods
Control and cough tendril-leaved fritillary bulb loquat drop pills, control and cough fritillary-loquat extract (pressing the preparation of embodiment 3 methods), produced by No.6 Chinese Medicine Factory, Tianjin Zhongxin Pharmaceutical Industry Group Co.
Animal: the ICR mice, 18-22g is provided by Beijing Vital River Experimental Animals Technology Co., Ltd., credit number: SCXK (capital) 2002-0003.
Aspirin effervescent tablets: jiangsu wuxi AstraZeneca pharmaceutical Co. Ltd
Dimethylbenzene: Tianjin northization glass purchase and sale center
Get 50 of healthy ICR mices, body weight 18～22g, be divided at random 5 groups, i.e. blank group, aspirin positive control (0.3g/kg), control and cough that the fritillary-loquat extract is low, high dose group (1.5,3.0g crude drug/kg), control and cough tendril-leaved fritillary bulb loquat drop pills group (1.5g crude drug/kg), except the blank group gave isopyknic pure water, all by the continuous gastric infusion of above-mentioned dosage 5 days, the administration volume was 20ml/kg to other administration groups.After 50 minutes, be coated with caused by dimethylbenzene xylene inflammation in the left ear of mice in the last administration, 20 μ l/, auris dextra is normal control.Take off cervical vertebra execution mice after 5 minutes and cut ears, lay round auricle at same position respectively with 9mm diameter card punch, analytical balance is weighed.Every left auricle of Mus heavily deducts the auris dextra sheet and heavily is swelling.Experimental data is added up with variance analysis.
Two. result: see Table 2.
Table 2 is controlled and is coughed the impact that fritillary-loquat extract xylol causes mice auricle swelling
Compare with the blank group
*P＜0.05,
*P＜0.01
The result shows: control and cough that the fritillary-loquat extract is low, high dose group and blank group more all have significant difference (P＜0.05, P＜0.01), shows that this active component all can obviously suppress the mice auricle swelling that dimethylbenzene causes.Under Isodose, though extract of the present invention is coughed tendril-leaved fritillary bulb loquat drop pills group comparison there was no significant difference with controlling, the trend that is better than former dosage form is arranged.Point out extract of the present invention that obvious antiinflammatory action is arranged.
Claims (10)
1. the Chinese medicine composition of a dispersing and descending lung-QI removing heat-phlegm, it is characterized in that: its active component is made by the raw material of following parts by weight: 0.34 part of Mentholum, 45 parts of Bulbus Fritillariae Ussuriensiss, 45 parts of Radix Platycodoniss, 45 parts of Rhizoma Pinelliae Preparatum, 300 parts of Folium Eriobotryaes; Active component adopts following method to prepare: take by weighing each raw material by proportioning raw materials; Bulbus Fritillariae Ussuriensis is pulverized, and gets fine powder A; The water extraction that Folium Eriobotryae, Radix Platycodonis, Rhizoma pinelliae cordatae are doubly measured with 6-12 2-3 time, each 1-3 hour, be concentrated into that relative density is 1.03-1.10 under the 50-60 ℃ of condition, obtain concentrated solution B; Mentholum and concentrated solution B are merged, and drying obtains dry thing I; Fine powder A and dry thing I are merged, obtain dry thing II, and get final product.
2. the Chinese medicine composition of a kind of dispersing and descending lung-QI removing heat-phlegm according to claim 1 is characterized in that: describedly take by weighing each raw material by proportioning raw materials; Bulbus Fritillariae Ussuriensis is pulverized, and gets fine powder A; The water extraction that Folium Eriobotryae, Radix Platycodonis, Rhizoma pinelliae cordatae are doubly measured with 8-10 2-3 time, each 1-2 hour, be concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, obtain concentrated solution B; Mentholum and concentrated solution B are merged, and drying obtains dry thing I; Fine powder A and dry thing I are merged, obtain dry thing II.
3. the Chinese medicine composition of a kind of dispersing and descending lung-QI removing heat-phlegm according to claim 2 is characterized in that: describedly take by weighing each raw material by proportioning raw materials; Bulbus Fritillariae Ussuriensis is pulverized, and gets fine powder A; Folium Eriobotryae, Radix Platycodonis, Rhizoma pinelliae cordatae be with the water extraction of 10 times of amounts 2 times, and each 2 hours, be concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, obtain concentrated solution B; Mentholum and concentrated solution B are merged, and drying obtains dry thing I; Fine powder A and dry thing I are merged, obtain dry thing II.
4. the Chinese medicine composition of any one described a kind of dispersing and descending lung-QI removing heat-phlegm in 3 according to claim 1, it is characterized in that: described pharmaceutical composition also contains the acceptable adjuvant of pharmaceutics.
5. the Chinese medicine composition of a kind of dispersing and descending lung-QI removing heat-phlegm according to claim 4, it is characterized in that: the acceptable adjuvant of described pharmaceutics is selected from any one or a few in starch, microcrystalline Cellulose, sucrose, aspartame, dextrin, lactose, Icing Sugar, glucose, sodium chloride, sodium carboxymethyl cellulose, crospolyvinylpyrrolidone, magnesium stearate, micropowder silica gel, vitamin C, cysteine, citric acid and the sodium sulfite.
6. the Chinese medicine composition of a kind of dispersing and descending lung-QI removing heat-phlegm according to claim 5, it is characterized in that: the dosage form of described Chinese medicine composition is peroral dosage form.
7. the Chinese medicine composition of a kind of dispersing and descending lung-QI removing heat-phlegm according to claim 6, it is characterized in that: described peroral dosage form is pill, tablet, capsule or oral liquid.
8. the preparation method of the Chinese medicine composition of a dispersing and descending lung-QI removing heat-phlegm takes by weighing 0.34 part of Mentholum, 45 parts of Bulbus Fritillariae Ussuriensiss, 45 parts of Radix Platycodoniss, 45 parts of Rhizoma Pinelliae Preparatum, 300 parts of Folium Eriobotryaes; Bulbus Fritillariae Ussuriensis is pulverized, and gets fine powder A; The water extraction that Folium Eriobotryae, Radix Platycodonis, Rhizoma pinelliae cordatae are doubly measured with 6-12 2-3 time, each 1-3 hour, be concentrated into that relative density is 1.03-1.10 under the 50-60 ℃ of condition, obtain concentrated solution B; Mentholum and concentrated solution B are merged, and drying obtains dry thing I; Fine powder A and dry thing I are merged, obtain dry thing II.
9. the preparation method of the Chinese medicine composition of a kind of dispersing and descending lung-QI removing heat-phlegm according to claim 8 is characterized in that: describedly take by weighing each raw material by proportioning raw materials; Bulbus Fritillariae Ussuriensis is pulverized, and gets fine powder A; The water extraction that Folium Eriobotryae, Radix Platycodonis, Rhizoma pinelliae cordatae are doubly measured with 8-10 2-3 time, each 1-2 hour, be concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, obtain concentrated solution B; Mentholum and concentrated solution B are merged, and drying obtains dry thing I; Fine powder A and dry thing I are merged, obtain dry thing II.
10. the preparation method of the Chinese medicine composition of a kind of dispersing and descending lung-QI removing heat-phlegm according to claim 8 is characterized in that: describedly take by weighing each raw material by proportioning raw materials; Bulbus Fritillariae Ussuriensis is pulverized, and gets fine powder A; Folium Eriobotryae, Radix Platycodonis, Rhizoma pinelliae cordatae be with the water extraction of 10 times of amounts 2 times, and each 2 hours, be concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, obtain concentrated solution B; Mentholum and concentrated solution B are merged, and drying obtains dry thing I; Fine powder A and dry thing I are merged, obtain dry thing II.
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