CN102716371B - Traditional Chinese medicine composition for curing chronic cough as well as preparation method and usages thereof - Google Patents
Traditional Chinese medicine composition for curing chronic cough as well as preparation method and usages thereof Download PDFInfo
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- CN102716371B CN102716371B CN201210236704.XA CN201210236704A CN102716371B CN 102716371 B CN102716371 B CN 102716371B CN 201210236704 A CN201210236704 A CN 201210236704A CN 102716371 B CN102716371 B CN 102716371B
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Abstract
The invention discloses a traditional Chinese medicine composition for curing chronic cough as well as a preparation method and usages thereof. The traditional Chinese medicine composition is prepared from reed rhizome, ordate houttuynia, rhizoma anemarrhenae and almond according to a certain proportioning by weight. The composition provided by the invention has an excellent curative effect to chronic cough caused by the deficiency of lung yin.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition that is used for the treatment of chronic cough and its production and use, belong to the field of Chinese medicines.
Background technology
Chronic cough is common clinical, frequently-occurring disease, is also common respiratory symptom.Doctor trained in Western medicine thinks that this disease is generally caused by eosinophilic granulocyte's property bronchitis, Postnasal drip syndrome, cough variant asthma, gastroesophageal reflux induced cough, allergia cough, the cause of disease is complicated, be one and relate to various diseases across the clinical symptoms of section, and by conventional methods such as history-taking, physical examination and chest film inspections, be often difficult to obtain and clarify a diagnosis.Generally speaking, the pulmonary lesion causing because of a variety of causes, after western medicines in treatment, as taken in a large number for a long time Western medicine and antibacterials, easily leave over long-term, obstinate chronic cough, touching difficult chance, the lighter can not affect orthobiosis, severe one can affect sleep, needs to recover for a long time and treatment.
The traditional Chinese medical science thinks, following reason easily causes chronic cough: the pathological changes repeatedly that Yi Shi pulmonary is long-term, with the passing of time injures lung yin; The 2nd, in the process of the acute pulmonary lesion for the treatment of, excessively used resolving phlegm and drying damp medicine or other medicine, thereby injured lung yin; The 3rd, patient's element body deficiency of YIN, lack of lung-YIN, easily meets exopathogen and invades, and easily sends out cough.
Because the chronic cough course of disease is long, need long-term taking medicine, and Western medicine or antibiotic often have stronger toleration and other side effect, and easily recurrence after drug withdrawal.Therefore need a kind of safe and effective medicine for the treatment of chronic cough.
Summary of the invention
The object of the invention be to provide a kind of be used for the treatment of chronic cough, Chinese medicine composition safely and effectively.
The present invention seeks to be achieved through the following technical solutions:
A Chinese medicine composition that is used for the treatment of chronic cough, the crude drug of described Chinese medicine composition consists of:
Rhizoma Phragmitis 25-40 weight portion Herba Houttuyniae 20-35 weight portion Rhizoma Anemarrhenae 10-20 weight portion Cortex Mori 8-15 weight portion Semen Armeniacae Amarum 8-15 weight portion.
Preferably, the crude drug of described Chinese medicine composition consists of:
Rhizoma Phragmitis 30-40 weight portion Herba Houttuyniae 20-30 weight portion Rhizoma Anemarrhenae 10-15 weight portion Cortex Mori 8-12 weight portion Semen Armeniacae Amarum 8-12 weight portion.
Preferably, the crude drug of described Chinese medicine composition consists of:
The Rhizoma Phragmitis 30 weight portion Herba Houttuyniae 20 weight portion Rhizoma Anemarrhenae 10 weight portion Cortex Mori 10 weight portion Semen Armeniacae Amarum 10 weight portions.
Preferably, the crude drug of described Chinese medicine composition consists of:
The Rhizoma Phragmitis 35 weight portion Herba Houttuyniae 25 weight portion Rhizoma Anemarrhenae 12 weight portion Cortex Mori 8 weight portion Semen Armeniacae Amarum 8 weight portions.
Preferably, the crude drug of described Chinese medicine composition consists of:
The Rhizoma Phragmitis 30 weight portion Herba Houttuyniae 30 weight portion Rhizoma Anemarrhenae 12 weight portion Cortex Mori 12 weight portion Semen Armeniacae Amarum 12 weight portions.
According to the preferred embodiment of the present invention, the preparation method of described Chinese medicine composition is preferably:
Get the crude drug of said ratio, add the water (by weight) that water 8-12 doubly measures and extract 2-4 time, each 1-3 hour, filters, merging filtrate, and the extractum that while being concentrated into 60 ℃, relative density is 1.30-1.40, is dried, and makes extract fine powder.
According to the preferred embodiment of the present invention, the extract obtained fine powder of above preparation method, adds suitable pharmaceutic adjuvant, with conventional method of Chinese medicinal, makes oral formulations, as tablet, pill, capsule and granule, is preferably capsule or granule.
The present invention also provides above-mentioned Chinese medicine composition to treat the purposes for the medicine of chronic cough in preparation.
Inventor, according to Chinese medical theory, carries out prescription for the chronic cough due to lack of lung-YIN, through long-term clinical practice, evident in efficacy.Rhizoma Phragmitis lung-yin nourishing in side, profit throat, replenishing body fluid and clearing away heat pathogen, as monarch drug; The removing toxic substances of Herba Houttuyniae clearing away lung-heat, also as monarch drug; The Rhizoma Anemarrhenae is the auxiliary Rhizoma Phragmitis lung-yin nourishing of ministerial drug; Cortex Mori is assisted the interior deficiency heat of Herba Houttuyniae lung heat clearing, is also ministerial drug; Semen Armeniacae Amarum is walked lung meridian, and logical lung qi relieving cough and resolving phlegm, and loosening bowel to relieve constipation, be adjuvant, thereby meet the pathomechanism of the lung and the large intestine being interior-exteriorly related, thereby reaches lung benefiting the moon, clearind deficient heat, the only effect of dry cough.In this side, all five kinds of Chinese medicine is the product of the medicine-food two-purpose of State Administration of Traditional Chinese Medicine's promulgation, can nourish lung yin by long-term taking, has no side effect.Because five kinds of Chinese medicine not only can be used as food but also can nourish lung yin, both can clear up large after being ill, remain in the waste heat of pulmonary after disease, can nourish again lung yin and recover healthy energy, thereby prevent pulmonary subinfection and pathological changes again, to reach lung benefiting the moon, the object of dry cough only.In addition, gomi herbs is find the side effect not, can long-term taking, more can avoid long-term taking antibiotic and the side effect that causes.
Chinese medicine composition of the present invention is through long-term clinical practice checking.During practical application, under the prerequisite of composition principle that does not depart from described pharmaceutical composition, the consumption of ingredients in described pharmaceutical composition is added and subtracted within the specific limits, in the amount ranges such as each taste medicine in claim 1, adjusted, all obtained very significant therapeutic effect.Clinical practice confirms, Chinese medicine composition of the present invention, no matter traditional decocting decoction still extracts the Chinese patent medicine of preparation through method for optimizing, no matter use separately, or with Western medicine drug combination, described pharmaceutical composition has all been obtained unexpected good result in the treatment of chronic cough, and does not find any toxic and side effects.In addition, in the present composition, five tastes crude drug is the product of medicine-food two-purpose, can also or be applied in medicated diet for patient's long-term taking as health product.
The specific embodiment
Inventor has carried out long-term clinical practice, and the treatment by the present composition for chronic cough is evident in efficacy, and without any side effects.Below, for the part clinical trial case of inventor's record, in order to further illustrate technique effect of the present invention, but the present invention is not formed to any restriction.
1. physical data
55 patients that choose are the Chronic Cough Patients that outpatient service is accepted for medical treatment, adopt table of random number method to be divided at random matched group and treatment group, matched group 27 examples wherein, male's 13 examples wherein, women's 14 examples, age 6-68 year, average 43.5 years old, the course of disease 5 months-6 years; Treatment group 28 examples, male's 13 examples wherein, women's 15 examples, age, 8-65 year, average 41.8 years old; The course of disease 2 months-5 years.Two groups of there are no significant in sex, age, course of disease differences, have comparability.
2. diagnostic criteria
The diagnostic criteria of chronic cough in Clinics and Practices guide (draft) the > > of the < < cough of promulgating for 2005 according to respirology branch of Chinese Medical Association asthma group;
Meanwhile, Syndrome Differentiation of Traditional Chinese Medicine is: lung yin loss type, and disease is seen dry cough, coughs sound very brief, expectorant is few or without expectorant, dry mouth and throat, or hectic fever in the afternoon, feverish sensation in the palms and soles, the night sweat of sleeping night, red tongue, few tongue, thready and rapid pulse.
3. Therapeutic Method
Matched group: ambroxol hydrochloride 30mg is oral, every day 3 times, ketotifen 1mg is oral, and 1 time every night, pentoxyverine 25mg is oral, every day 3 times.2 weeks courses for the treatment of.
Treatment group: Chinese medicine composition granulation of the present invention agent, preparation method is: get Rhizoma Phragmitis 600g, Herba Houttuyniae 400g, Rhizoma Anemarrhenae 200g, Cortex Mori 200g, Semen Armeniacae Amarum 200g, decoct with water and extract 3 times, amount of water is respectively 10 times, 8 times, 8 times, decocting time is respectively 1.5 hours, filter, merging filtrate, the extractum that while being evaporated to 60 ℃, relative density is 1.31～1.34, 50 ℃ of drying under reduced pressure, be ground into fine powder, add appropriate soluble dextrins, Icing Sugar and 0.01% cyclamate, mix, with alcohol granulation, 40 ℃ following dry, granulation agent 1000g, every gram is equivalent to 1.60 grams of crude drugs.Instructions of taking: every day 3 times, each 8g.
4. criterion of therapeutical effect
Curative effect determinate standard with reference to chronic cough in < < disease of tcm Standardization of diagnosis and curative effect > >.
Cure: cough disappears, and related symptoms and tongue, pulse condition obviously improve, more than 2 weeks do not send out author for clinical cure.Effective: cough alleviates, and severe transfers moderate to or moderate transfers to slightly, and related symptoms and tongue, pulse condition make moderate progress.Invalid: cough is without changing or increasing the weight of.
5. result
Treatment group is cured 18 examples, effective 6 examples, invalid 4 examples, total effective rate 85.71%; Matched group is cured 12 examples, effective 6 examples, and no effect 9,66.67%, two group of total effective rate comparison of total effective rate, difference has statistical significance.
6. conclusion
For the chronic cough due to lack of lung-YIN, compare with conventional western medicine, treatment group has obtained good therapeutic effect (total effective rate reaches 85.71%), and medical material of the present invention forms the product that are medicine-food two-purpose, drug safety, without toleration and other toxic and side effects.
The embodiment of Chinese medicine composition of the present invention is described by the following examples, but described embodiment is not construed as limiting to the present invention.
Embodiment 1
Get Rhizoma Phragmitis 700g, Herba Houttuyniae 500g, Rhizoma Anemarrhenae 240g, Cortex Mori 160g, Semen Armeniacae Amarum 160g, decocts with water and extracts 3 times, each amount of water is respectively 12,10,8 times of amounts, and each decocting time is 3,2,1 hours, filters, merging filtrate, the extractum that while being evaporated to 60 ℃, relative density is 1.33～1.35, spraying is dry, makes fine powder, add appropriate carboxymethyl starch sodium, microcrystalline Cellulose and magnesium stearate, compacting in flakes.
Embodiment 2
Get Rhizoma Phragmitis 600g, Herba Houttuyniae 400g, Rhizoma Anemarrhenae 200g, Cortex Mori 200g, Semen Armeniacae Amarum 200g, decocts with water and extracts 3 times, amount of water is respectively 10 times, 8 times, 8 times, and decocting time is respectively 1.5 hours, filters, merging filtrate, the extractum that while being evaporated to 60 ℃, relative density is 1.31～1.34,50 ℃ of drying under reduced pressure, be ground into fine powder, add the cyclamate of appropriate soluble dextrins, Icing Sugar and 0.01%, mix, with alcohol granulation, 40 ℃ following dry, granulation agent.
Embodiment 3
Get Rhizoma Phragmitis 600g, Herba Houttuyniae 600g, Rhizoma Anemarrhenae 240g, Cortex Mori 240g, Semen Armeniacae Amarum 240g, decocts with water and extracts 3 times, add 10 times of amounts of water at every turn, decoct 1.5 hours, filter, merging filtrate, the extractum that while being evaporated to 60 ℃, relative density is 1.35～1.40,50 ℃ of drying under reduced pressure, be ground into fine powder, add appropriate amount of starch, with alcohol granulation, dry, dress up hard capsule.
Claims (8)
1. a Chinese medicine composition that is used for the treatment of the chronic cough due to lack of lung-YIN, the crude drug of described Chinese medicine composition consists of:
Rhizoma Phragmitis 25-40 weight portion, Herba Houttuyniae 20-35 weight portion, Rhizoma Anemarrhenae 10-20 weight portion, Cortex Mori 8-15 weight portion, Semen Armeniacae Amarum 8-15 weight portion.
2. Chinese medicine composition according to claim 1, is characterized in that, the crude drug of described Chinese medicine composition consists of:
The Rhizoma Phragmitis 30 weight portion Herba Houttuyniae 20 weight portion Rhizoma Anemarrhenae 10 weight portion Cortex Mori 10 weight portion Semen Armeniacae Amarum 10 weight portions.
3. Chinese medicine composition according to claim 1, is characterized in that, the crude drug of described Chinese medicine composition consists of:
The Rhizoma Phragmitis 35 weight portion Herba Houttuyniae 25 weight portion Rhizoma Anemarrhenae 12 weight portion Cortex Mori 8 weight portion Semen Armeniacae Amarum 8 weight portions.
4. Chinese medicine composition according to claim 1, is characterized in that, the crude drug of described Chinese medicine composition consists of:
The Rhizoma Phragmitis 30 weight portion Herba Houttuyniae 30 weight portion Rhizoma Anemarrhenae 12 weight portion Cortex Mori 12 weight portion Semen Armeniacae Amarum 12 weight portions.
5. according to the Chinese medicine composition described in claim 1-4 any one, it is characterized in that, the preparation method of described Chinese medicine composition comprises:
Get described crude drug, add water extraction 2-4 time that 8-12 doubly measures by weight, each 1-3 hour, filters, merging filtrate, and the extractum that while being concentrated into 60 ℃, relative density is 1.30-1.40, dry, pulverize, and obtains extract powder.
6. Chinese medicine composition according to claim 5, is characterized in that, described extract powder adds suitable pharmaceutic adjuvant, with conventional method of Chinese medicinal, makes oral formulations.
7. Chinese medicine composition according to claim 6, is characterized in that, described oral formulations is tablet, pill, capsule or granule.
8. the purposes in the medicine of the chronic cough due to preparation treatment lack of lung-YIN according to the Chinese medicine composition described in claim 1-7 any one.
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| CN201210236704.XA CN102716371B (en) | 2012-07-10 | 2012-07-10 | Traditional Chinese medicine composition for curing chronic cough as well as preparation method and usages thereof |
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| CN102716371B true CN102716371B (en) | 2014-11-05 |
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| CN103263059B (en) * | 2013-05-23 | 2014-06-18 | 圣原健康产业有限公司 | Solid beverage for clearing away lung-heat, promoting diuresis, reducing phlegm and relieving cough and preparation method thereof |
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| CN1876075A (en) * | 2006-04-28 | 2006-12-13 | 王志岐 | A medicine for treating asthma, acute and chronic bronchitis and preparation method thereof |
| CN102552778A (en) * | 2012-02-20 | 2012-07-11 | 成都中医药大学 | Medicinal composition for treating cough, and preparation method and application thereof |
| CN102580037A (en) * | 2012-03-15 | 2012-07-18 | 广东省中医院 | Chinese medicinal composition for treating cough caused by cold-type infection and preparation method thereof |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1876075A (en) * | 2006-04-28 | 2006-12-13 | 王志岐 | A medicine for treating asthma, acute and chronic bronchitis and preparation method thereof |
| CN102552778A (en) * | 2012-02-20 | 2012-07-11 | 成都中医药大学 | Medicinal composition for treating cough, and preparation method and application thereof |
| CN102580037A (en) * | 2012-03-15 | 2012-07-18 | 广东省中医院 | Chinese medicinal composition for treating cough caused by cold-type infection and preparation method thereof |
Non-Patent Citations (5)
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| 刘典功."鱼腥草与芦根".《中药指征相类鉴别应用》.2008, * |
| 吕华.清咽汤治疗慢性咳嗽60例.《陕西中医》.2008,(第04期), * |
| 李浩等."鱼腥草芦根饮".《中华药膳防治呼吸系统疾病》.2011, * |
| 清咽汤治疗慢性咳嗽60例;吕华;《陕西中医》;20081231(第04期);全文 * |
| 顾奎琴."芦根杏仁粥".《烟民护肺饮食指导》.2008, * |
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