CN101664524A - Medicament for treating paranasal sinusitis and preparation method thereof - Google Patents

Abstract

The invention relates to a medicament for treating paranasal sinusitis, which is a capsule product prepared by the following steps: evenly mixing the prepared cocklebur fruit with honeysuckle, flowerbud of lily magnolia, astragalus mongholicus, scutellaria baicalensis, gypsum, radix angelicae, ligusticum wallichii, adlay, red paeony root, platycodon grandiflorum, fructus aurantii, fructus forsythiae, peach kernel, red flower, fructus viticis and liquorice; adding water to decoct and condensing the mixture to paste; drying, smashing and packing to the capsule; sterilizing and disinfecting to obtain the capsule product. The medicament has the advantages of expelling wind and cold pathogens, clearing away heat and toxic material, clearing sinus, removing blood stasis and apocenosis, strengthening the body resistance to eliminate pathogenic factors. The medicament is reliable, rapid and convenient to treat paranasal sinusitis and is safe to take, and the effective rate thereof is 97.0% according to clinic observation.

Description

A kind of medicine that is used for the treatment of nasal sinusitis and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of nasal sinusitis, particularly relating to a kind of is the medicine of the treatment nasal sinusitis of crude drug preparation with Chinese medicine.The invention still further relates to the preparation method of this medicine.

Background technology

Nasal sinusitis is the nonspecific inflammation of nasal sinuses mucosa, is a kind of nose section common disease.Primary disease is the overwhelming majority caused by Common Cold, and whole body is lower for the resistance, and other nose diseases often has nasal mucus to block, and swimming, diving method are improper, and air pressure changes (as flight, diving etc.) rapidly and all can cause the primary disease generation.Nasal sinusitis generally is divided into acute and chronic 2 classes, and acute nasal sinusitis is the acute suppurative inflammation of nasal membrane, can fall ill separately by a nasal sinuses, also can be several nasal sinuses inflammation simultaneously, if acute nasal sinusitis malpractice, or outbreak repeatedly can cause chronic paranasal rhinitis.Acute nasal sinusitis often has headache, nasal obstruction, rhinorrhea, symptoms such as temporary olfactory disorder and fear of cold, heating, inappetence, constipation, whole body discomfort, chronic paranasal rhinitis often shows as headache, nasal obstruction, the pus tears are many, hyposmia, or with abundant expectoration, foreign body in pharynx sense etc.

Doctor trained in Western medicine is taked Drug therapy and operative treatment to the treatment of nasal sinusitis more at present, Drug therapy mainly comprises nasal mucosa contracting agent, antibiotic and adrenocortical hormone etc., operative treatment mainly is the functional Minimally Invasive Surgery of conchoscope, though these therapies are effective, but often cure the symptoms, not the disease, effect is not ideal enough, and many patient Chang Jingjiu are not healed.

Summary of the invention

The purpose of this invention is to provide a kind of medicine that is used for the treatment of nasal sinusitis, this Drug therapy nasal sinusitis treating both the principal and secondary aspects of a disease, drug effect is rapid, and therapeutic effect is good.

A kind of preparation method of described medicine is provided, and is another goal of the invention of the present invention.

Medicine of the present invention is that crude drug prepares by following parts by weight of traditional Chinese medicines:

Flos Lonicerae 10～30 Flos Magnoliaes 5～20

Fructus Xanthii 3～15 Radixs Astragali 10～50

Radix Scutellariae 5～20 Gypsum Fibrosum 10～45

The Radix Angelicae Dahuricae 6～25 Rhizoma Chuanxiongs 5～35

Semen Coicis 15～50 Radix Paeoniae Rubra 10～25

Radix Platycodonis 5～20 Fructus Aurantiis 5～20

Fructus Forsythiae 5～20 Semen Persicaes 5～20

Flos Carthami 5～20 Fructus Viticises 5～20

Radix Glycyrrhizae 3～12.

Said medicine can be made any dosage form on the pharmaceutics, as tablet, pill, powder, capsule etc., the preferred dosage form of the present invention is a capsule.

The concrete preparation method of medicine of the present invention being made capsule is:

Get the Fructus Xanthii parching to brown, dry standby; With the Fructus Xanthii that cooks and Flos Lonicerae, Flos Magnoliae, the Radix Astragali, Radix Scutellariae, Gypsum Fibrosum, the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Semen Coicis, Radix Paeoniae Rubra, Radix Platycodonis, Fructus Aurantii, Fructus Forsythiae, Semen Persicae, Flos Carthami, Fructus Viticis, Radix Glycyrrhizae according to described parts by weight mix homogeneously, decoct with water 2～4 times, each 1～2 hour, collecting decoction filters, and is condensed into the thick paste of 60 ℃ of relative densities 1.1～1.3, after 50～60 ℃ of dryings, be ground into 120 purpose medicated powder, incapsulate, sterilization is made the capsule product.

Further, the crude drug of preparation medicine of the present invention can also include the Rhizoma Pinelliae, Pericarpium Citri Reticulatae, Flos Chrysanthemi, Fructus Lycii, and the raw material medicines in portions by weight number that it comprises is:

Flos Lonicerae 10～30 Flos Magnoliaes 5～20

Fructus Xanthii 3～15 Radixs Astragali 10～50

Radix Scutellariae 5～20 Gypsum Fibrosum 10～45

The Radix Angelicae Dahuricae 6～25 Rhizoma Chuanxiongs 5～35

Semen Coicis 15～50 Radix Paeoniae Rubras 10～25

Radix Platycodonis 5～20 Fructus Aurantiis 5～20

Fructus Forsythiae 5～20 Semen Persicaes 5～20

Flos Carthami 5～20 Fructus Viticises 5～20

Pericarpium Citri Reticulatae 6～20 Rhizoma Pinelliaes 5～20

Fructus Lycii 8～30 Flos Chrysanthemis 5～20

Radix Glycyrrhizae 3～12.

The medicine concrete preparation method that has increased the Rhizoma Pinelliae, Pericarpium Citri Reticulatae, Flos Chrysanthemi, Fructus Lycii crude drug is:

With the Fructus Xanthii parching to brown, dry standby; The Rhizoma Pinelliae was soaked 2～4 hours with clear water, dry after clean standby with flushing with clean water;

With the above-mentioned Chinese medicine that cooks and Flos Lonicerae, Flos Magnoliae, the Radix Astragali, Radix Scutellariae, Gypsum Fibrosum, the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Semen Coicis, Radix Paeoniae Rubra, Radix Platycodonis, Fructus Aurantii, Fructus Forsythiae, Semen Persicae, Flos Carthami, Fructus Viticis, Pericarpium Citri Reticulatae, Flos Chrysanthemi, Fructus Lycii, Radix Glycyrrhizae according to described parts by weight mix homogeneously, decoct with water 2～4 times, each 1～2 hour, collecting decoction, filter, be condensed into the thick paste of 60 ℃ of relative densities 1.1～1.3, after 50～60 ℃ of dryings, be ground into 120 purpose medicated powder, incapsulate, sterilization is made the capsule product.

How solid by the deficiency of vital energy nasal sinusitis belongs to the traditional Chinese medical science " nasal sinusitis ", " sinusitis with purulent discharge " category,, the exopathogen invasion and attack, heresy is gone into heat-transformation, damp and hot accumulate long-pending, the saprophytic pus that burns, lead to expectorant turbid due to, main pathogenesis is to accumulate in the pyretic toxicity, the nose key loses a surname.The suitable expelling wind and cold of treatment, heat-clearing and toxic substances removing, a surname's clearing the nasal passage, blood stasis dispelling evacuation of pus, strengthening vital QI to eliminate pathogenic factors.Medicament selection Flos Lonicerae of the present invention, Fructus Xanthii, Flos Magnoliae, the Radix Astragali, Radix Scutellariae, Gypsum Fibrosum, the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Semen Coicis, Radix Paeoniae Rubra, Radix Platycodonis, Fructus Aurantii, Fructus Forsythiae, Semen Persicae, Flos Carthami, Fructus Viticis, Radix Glycyrrhizae combination, Flos Magnoliae, the Radix Angelicae Dahuricae, Fructus Xanthii powder wind and cold, clearing the nasal passage in the side; The Fructus Viticis dispelling wind and heat pathogens, wind-expelling pain-stopping, tonneau nine orifices; Flos Lonicerae, floating a surname of the light clear liter of Fructus Forsythiae loose heat-clearing and toxic substances removing, dispersing swelling and dissipating binds pain relieving; Gypsum Fibrosum loses heart clearly and divides excess-heat, and Radix Scutellariae is apt to clear part of the body cavity above the diaphragm housing the heart and lungs lung-fire, eliminating fire and detoxication; Semen Persicae, Flos Carthami, Rhizoma Chuanxiong, Radix Paeoniae Rubra blood circulation promoting and blood stasis dispelling; Shang Daxia is drawn in Radix Platycodonis, Fructus Aurantii one rise and one drop, makes the efficacy of a drug sick institute that goes directly, and drawing heresy again has outlet; Semen Coicis damp eliminating evacuation of pus, Radix Astragali consolidating superficial resistance is set upright, the Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.All medicines share, and are total to the long memorial wind, dissipating cold, heat-clearing and toxic substances removing, a surname's clearing the nasal passage, blood stasis dispelling evacuation of pus, the merit of strengthening vital QI to eliminate pathogenic factors.In order to reach better therapeutic, also added the Rhizoma Pinelliae, Pericarpium Citri Reticulatae, Flos Chrysanthemi, Fructus Lycii in the medicine of the present invention, the Rhizoma Pinelliae, Pericarpium Citri Reticulatae activating QI to eliminate phlegm, the Flos Chrysanthemi liver heat removing is through wind heat, and the Fructus Lycii nourishing the liver and kidney is to set upright.Behind these 4 kinds of drug regimens, the effect of strengthening vital QI to eliminate pathogenic factors is stronger, and curative effect is better, is used for the treatment of the nasal sinusitis curative effect really, rapidly, conveniently, takes safety.

For further investigating the clinical efficacy and the safety of medicine of the present invention, select 100 routine nasal sinusitis patients that the curative effect of medicine of the present invention has been carried out clinical observation.Among the 100 routine patients, male 53 examples, women 47 examples; Suffer from acute nasal sinusitis 62 examples, chronic paranasal rhinitis 38 examples; Minimum 14 years old of age, maximum 45 years old; Disease time is the longest 5 years, and is the shortest 14 days.All case all meets nasal sinusitis diagnostic criteria in " traditional Chinese medical science disease diagnosis criterion of therapeutical effect ".

Therapeutic Method: oral medicine of the present invention, 1 time 3,1 day 3 times, acute nasal sinusitis serve on for 2 weeks, chronic paranasal rhinitis serve on for 3 weeks.

Criterion of therapeutical effect: the criterion of therapeutical effect with reference to " nasal sinusitis " in " traditional Chinese medical science disease diagnosis criterion of therapeutical effect " is drafted.Cure: transference cure, X line nasal sinuses sheet is no abnormal; Take a turn for the better: symptom is obviously improved, and the nasal cavity inspection sees that performances such as hyperemia, mucosa swelling alleviate, and X line nasal sinuses sheet has clear improvement; Invalid: sings and symptoms does not have improvement.

100 routine patients cure 58 examples (58.0%), 39 examples that take a turn for the better (39.0%), invalid 3 examples (3.0%), effective percentage 97.0% after treatment.

The specific embodiment

Embodiment 1

Get Fructus Xanthii 300g, parching to brown dries standby.

With above-mentioned Fructus Xanthii (parched) and Flos Lonicerae 1000g, Flos Magnoliae 500g, Radix Astragali 1500g, Radix Scutellariae 500g, Gypsum Fibrosum 750g, Radix Angelicae Dahuricae 500g, Rhizoma Chuanxiong 500g, Semen Coicis 1500g, Radix Paeoniae Rubra 750g, Radix Platycodonis 500g, Fructus Aurantii 500g, Fructus Forsythiae 500g, Semen Persicae 500g, Flos Carthami 300g, Fructus Viticis 500g, Radix Glycyrrhizae 300g mix homogeneously, decoct with water 3 times, each 1.5 hours, collecting decoction, filter, be condensed into the thick paste of 60 ℃ of relative densities 1.2, after 50 ℃ of dryings, be ground into 120 purpose medicated powder, in incapsulating, sterilization is made the capsule product.

Embodiment 2

Get Fructus Xanthii 360g, parching to brown dries standby; Get Rhizoma Pinelliae 600g, soaked 3 hours, dry after clean standby with flushing with clean water with clear water;

With above-mentioned Chinese medicine that cooks and Flos Lonicerae 1200g, Flos Magnoliae 600g, Radix Astragali 1800g, Radix Scutellariae 600g, Gypsum Fibrosum 900g, Radix Angelicae Dahuricae 600g, Rhizoma Chuanxiong 600g, Semen Coicis 1800g, Radix Paeoniae Rubra 900g, Radix Platycodonis 600g, Fructus Aurantii 600g, Fructus Forsythiae 600g, Semen Persicae 600g, Flos Carthami 360g, Fructus Viticis 600g, Pericarpium Citri Reticulatae 600g, Flos Chrysanthemi 600g, Fructus Lycii 900g, Radix Glycyrrhizae 300g mix homogeneously, decoct with water 3 times, each 1.5 hours, collecting decoction, filter, be condensed into the thick paste of 60 ℃ of relative densities 1.2, after 50 ℃ of dryings, be ground into 120 purpose medicated powder, incapsulate, sterilization is made the capsule product.

Claims (4)

1, a kind of medicine that is used for the treatment of nasal sinusitis is that crude drug prepares by the Chinese medicine of following portions by weight:

Flos Lonicerae 10～30 Flos Magnoliaes 5～20

Fructus Xanthii 3～15 Radixs Astragali 10～50

Radix Scutellariae 5～20 Gypsum Fibrosum 10～45

The Radix Angelicae Dahuricae 6～25 Rhizoma Chuanxiongs 5～35

Semen Coicis 15～50 Radix Paeoniae Rubra 10～25

Radix Platycodonis 5～20 Fructus Aurantiis 5～20

Fructus Forsythiae 5～20 Semen Persicaes 5～20

Flos Carthami 5～20 Fructus Viticises 5～20

Radix Glycyrrhizae 3～12.

2, the described preparation method that is used for the treatment of the medicine of nasal sinusitis of claim 1 may further comprise the steps:

Get the Fructus Xanthii parching to brown, dry standby; With the Fructus Xanthii that cooks and Flos Lonicerae, Flos Magnoliae, the Radix Astragali, Radix Scutellariae, Gypsum Fibrosum, the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Semen Coicis, Radix Paeoniae Rubra, Radix Platycodonis, Fructus Aurantii, Fructus Forsythiae, Semen Persicae, Flos Carthami, Fructus Viticis, Radix Glycyrrhizae according to described parts by weight mix homogeneously, decoct with water 2～4 times, each 1～2 hour, collecting decoction filters, and is condensed into the thick paste of 60 ℃ of relative densities 1.1～1.3, after 50～60 ℃ of dryings, be ground into 120 medicated powder, incapsulate, sterilization is made the capsule product.

3, a kind of medicine that is used for the treatment of nasal sinusitis is that crude drug prepares by the Chinese medicine of following portions by weight:

Flos Lonicerae 10～30 Flos Magnoliaes 5～20

Fructus Xanthii 3～15 Radixs Astragali 10～50

Radix Scutellariae 5～20 Gypsum Fibrosum 10～45

The Radix Angelicae Dahuricae 6～25 Rhizoma Chuanxiongs 5～35

Semen Coicis 15～50 Radix Paeoniae Rubras 10～25

Radix Platycodonis 5～20 Fructus Aurantiis 5～20

Fructus Forsythiae 5～20 Semen Persicaes 5～20

Flos Carthami 5～20 Fructus Viticises 5～20

Pericarpium Citri Reticulatae 6～20 Rhizoma Pinelliaes 5～20

Fructus Lycii 8～30 Flos Chrysanthemis 5～20

Radix Glycyrrhizae 3～12.

4, the described preparation method that is used for the treatment of the medicine of nasal sinusitis of claim 3 may further comprise the steps:

With the Fructus Xanthii parching to brown, dry standby; The Rhizoma Pinelliae was soaked 2～4 hours with clear water, dry after clean standby with flushing with clean water;

With the above-mentioned Chinese medicine that cooks and Flos Lonicerae, Flos Magnoliae, the Radix Astragali, Radix Scutellariae, Gypsum Fibrosum, the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Semen Coicis, Radix Paeoniae Rubra, Radix Platycodonis, Fructus Aurantii, Fructus Forsythiae, Semen Persicae, Flos Carthami, Fructus Viticis, Pericarpium Citri Reticulatae, Flos Chrysanthemi, Fructus Lycii, Radix Glycyrrhizae according to described parts by weight mix homogeneously, decoct with water 2～4 times, each 1～2 hour, collecting decoction, filter, be condensed into the thick paste of 60 ℃ of relative densities 1.1～1.3, after 50～60 ℃ of dryings, be ground into 120 purpose medicated powder, incapsulate, sterilization is made the capsule product.