CN101987156A - Medicine for treating toothache and preparation method thereof - Google Patents
Medicine for treating toothache and preparation method thereof Download PDFInfo
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- CN101987156A CN101987156A CN 201010264933 CN201010264933A CN101987156A CN 101987156 A CN101987156 A CN 101987156A CN 201010264933 CN201010264933 CN 201010264933 CN 201010264933 A CN201010264933 A CN 201010264933A CN 101987156 A CN101987156 A CN 101987156A
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Abstract
The invention discloses a medicine for treating toothache, which is characterized by being prepared from the following main raw materials in parts by weight: 1-20 parts of rose, 1-20 parts of seville orange flower, 1-20 parts of cassia bark powder, 1-20 parts of prepared rehmannia rhizome, 1-20 parts of prepared daughter root of common monkshood, 1-20 parts of pulp of cornus, 1-20 parts of oriental waterplantain rhizome, 1-20 parts of bark of peony tree, 1-20 parts of poria cocos, 1-20 parts of twotooth achyranthes root, 1-20 parts of plantain seed, 1-20 parts of asarum, 1-20 parts of figwort root, 1-20 parts of Chinese yam and 1-20 parts of edible alcohol with the content above 95 percent. The medicine can be absorbed via the spleen and the stomach through oral administration and via the skin through external use, and can also be absorbed in a combinational way through the oral administration and the external use. The medicine of the invention has the advantages of reasonable formulation, simplified compatibility and definite curative effect and can be used for treating the principal and secondary aspects of a disease. The invention further provides a preparation method of the medicine.
Description
Technical field
The invention belongs to the field of Chinese medicines, medicine of the treatment toothache of particularly a kind of oral administration or external and preparation method thereof.
Background technology
Toothache is meant that tooth says because of the pain that a variety of causes causes, is one of symptom common in the oral disease, is found in dental caries, pulpitis, apical periodontitis and the dentin hypersensitiveness etc. of western medicine.Toothache outbreak or increase the weight of when meeting stimulation such as hot and cold, sour, sweet belongs to " gingival atrophy ", " osteomyelitis of the maxillary bone " category of the traditional Chinese medical science.Hands, sufficient Yangming Channel arteries and veins divide others' lower tooth, go up tooth, and large intestine, the long-pending heat of stomach internal organs, or ailment said due to cold or exposure attacks meridians outward are strongly fragrant in Yang Ming and fire-transformation, and pathogenic fire is followed and sent out toothache through last inflammation.Kidney governing bones, tooth being the surplus of the bone, deficiency of kidney yin, hyperactivity of deficient fire also can cause toothache.The thing of the sweet acid of polyphagia is also arranged, and ability to speak is unclean, dirty dirty erosion tooth and the person of having a pain.Therefore, toothache is main relevant with brothers' Yangming Channel and kidney channel.
Chinese patent CN200410079326.4 discloses a kind of sick Chinese medicine of toothache for the treatment of, and it adopts Camphora, Sal, Fructus Forsythiae, Herba Menthae, Radix Gentianae, Poria, Radix Rubiae, Radix Scrophulariae is that raw material is made Chinese medicine pill.Chinese patent CN03110842.3 discloses a kind of Chinese medicine for the treatment of toothache, comprise following composition: Rhizoma Cimicifugae, calculogenesis lamb, Radix Glycyrrhizae, unpeeled CORTEX MOUTAN, Rhizoma Coptidis, Radix Et Rhizoma Rhei, peppermint stem, Herba Asari, Radix Scrophulariae, Semen Pittospori Glabrati, the weight ratio umber of its each composition is: Rhizoma Cimicifugae 15-25 part, calculogenesis lamb 25-35 part, Radix Glycyrrhizae 10-20 part, unpeeled CORTEX MOUTAN 10-20 part, Rhizoma Coptidis 15-25 part, Radix Et Rhizoma Rhei 15-25 part, peppermint stem 10-20 part, Herba Asari 10-20 part, Radix Scrophulariae 15-25 part, Semen Pittospori Glabrati 10-20 part.Chinese patent CN200610041929.4 discloses a kind of Chinese medicinal liniment that is used for the treatment of toothache, is made of Oleum Sesami or other edible oil and raw material the effective elements of the medicine, and wherein crude drug is a Pollen Pini, Pericarpium Zanthoxyli, Borneolum Syntheticum, Flos Caryophylli, Mentholum, Herba Schizonepetae, Fructus Piperis Longi, Herba Artemisiae Scopariae, Radix Glycyrrhizae, Fructus Anisi Stellati.
The Chinese medicine product of above-mentioned treatment toothache is paid attention to regulating too much, has reduced the medicine proportion of a therapeutical effect relatively, has influenced the pharmic function performance, so effect is slow, the course of treatment is long, and effect is undesirable.And existing Chinese medicine oral administration but can not external, but can not the taking orally again of external, route of administration is single, makes the patient slow to the absorption of medicine.Chinese medicine for oral administration not only absorbs slowly, and causes spleen injury easily, even increase the weight of the state of an illness for the patient of weakness of the spleen and stomach.
Chinese medicine is taken difficulty owing to mostly be decoction or the pill that boils than Western medicine, has also influenced the popularization of Chinese medicine widely.
Summary of the invention
The objective of the invention is to overcome the defective that prior art exists, a kind of reasonable recipe is provided, compatibility is simplified, the medicine of the treatment of determined curative effect, treating both the principal and secondary aspects of a disease toothache, to control, control foster combination, and this medicine can take orally by taste absorb again can external by skin absorbs, can also oral administration and externally used dual mode composite absorption.This compound administering mode helps the efficient absorption of human body to medicine, and for the crowd of weakness of the spleen and stomach, the medicine that is busy with one's work, spares oneself provides multiple choices, especially the patient by the modern job crowd is accepted.
Technical scheme of the present invention is as follows:
A kind of medicine for the treatment of toothache is characterized in that it mainly is to be made by the raw material of following weight portion: 1 ~ 20 part of Flos Rosae Rugosae, 1 ~ 20 part of CitrusaurantiumL.Var.amara Engl., 1 ~ 20 part of cinnamon powder, 1 ~ 20 part in Radix Rehmanniae Preparata, 1 ~ 20 part of RADIX ACONITILATERALIS PREPARATA, 1 ~ 20 part of Fructus Corni, 1 ~ 20 part of Rhizoma Alismatis, 1 ~ 20 part of Cortex Moutan, 1 ~ 20 part in Poria, 1 ~ 20 part of Radix Achyranthis Bidentatae, 1 ~ 20 part of Semen Plantaginis, 1 ~ 20 part of Herba Asari, 1 ~ 20 part of Radix Scrophulariae, 1 ~ 20 part of Rhizoma Dioscoreae, content is 1 ~ 20 part of edible ethanol more than 95%.
Further, the consumption of each component of medicine of the present invention is: 15 ~ 20 parts of Flos Rosae Rugosaes, 15 ~ 20 parts of CitrusaurantiumL.Var.amara Engl.s, 15 ~ 20 parts of cinnamon powders, 15 ~ 20 parts in Radix Rehmanniae Preparata, 15 ~ 20 parts of RADIX ACONITILATERALIS PREPARATA, 15 ~ 20 parts of Fructus Corni, 15 ~ 20 parts of Rhizoma Alismatis, 15 ~ 20 parts of Cortex Moutans, 15 ~ 20 parts in Poria, 15 ~ 20 parts of Radix Achyranthis Bidentataes, 15 ~ 20 parts of Semen Plantaginiss, 15 ~ 20 parts of Herba Asaris, 15 ~ 20 parts of Radix Scrophulariaes, 15 ~ 20 parts of Rhizoma Dioscoreaes, content is 15 ~ 20 parts of edible ethanols more than 95%.
The middle survival dose of above compatibility is the crude drug amount.
In order to strengthen the transdermal effect of medicine, can also mix transdermal agent in the medicine of the present invention, preferably weight portion is 1 ~ 5 part a azone.
Another object of the present invention provides manufacturing method for above mentioned medicine, it is characterized in that comprising the following steps:
A) take by weighing Flos Rosae Rugosae, CitrusaurantiumL.Var.amara Engl., cinnamon powder, Radix Rehmanniae Preparata, RADIX ACONITILATERALIS PREPARATA, Fructus Corni, Rhizoma Alismatis, Cortex Moutan, Poria, Radix Achyranthis Bidentatae, Semen Plantaginis, Herba Asari, Radix Scrophulariae and the Rhizoma Dioscoreae of described weight proportion, according to the conventional extracting method of Chinese medicine, the extract of the former medicine that obtains respectively respectively to distinguish the flavor of;
B) under the room temperature, get the deionized water of 5 ~ 6 times of amounts, the content that adds described weight proportion is the edible ethanol more than 95%, is mixed with aqueous solution of alcohol;
C) with in the above-mentioned aqueous solution of alcohol of the extract obtained adding of step a, stirred 120 minutes, precipitate 2 ~ 4 hours, filter, gained filtrate sterilization, fill according to quantity must be treated the medicine of toothache.
Further, among the step c, can add in the aqueous solution of alcohol together by azone step a is extract obtained and 1 ~ 5 weight portion.
The conventional extracting method of described Chinese crude drug can adopt decocting method, circumfluence method, infusion process, percolation, semi-bionic extraction, supercritical fluid extraction, microwave extraction method etc. according to the kind of medical material.
The present invention is directed to the characteristics of toothache, select Flos Rosae Rugosae, CitrusaurantiumL.Var.amara Engl., cinnamon powder, Radix Rehmanniae Preparata, RADIX ACONITILATERALIS PREPARATA, Fructus Corni, Rhizoma Alismatis, Cortex Moutan, Poria, Radix Achyranthis Bidentatae, Semen Plantaginis, Herba Asari, Radix Scrophulariae, Rhizoma Dioscoreae for use, with being that edible ethanol more than 95% mixes with content after each flavor Chinese medicine extraction, make to contain pure Chinese medicine extraction liquid.Employing to be to control, and control and support bonded method, but not only also external of oral administration of the medicine of making is a kind of reasonable recipe, and compatibility is simplified, the medicine of the treatment toothache of determined curative effect, treating both the principal and secondary aspects of a disease.
Cinnamon powder is hidden hot, and temperature is gone into kidney, spleen, urinary bladder channel; The complement sun, warming the spleen and stomach, removing accumulated cold, promoting blood circulation.Radix Rehmanniae Preparata is sweet, and tepor is gone into liver, kidney channel; YIN nourishing is enriched blood.The RADIX ACONITILATERALIS PREPARATA recuperating depleted YANG and rescuing the patient from collapse, warming and recuperating the spleen and kidney, dispersing cold for relieving pain.The big heat of Da Xin, warming YANG is by cold.Fructus Corni sour in the mouth, puckery, tepor is returned liver, kidney channel; Liver and kidney tonifying, essence astringing and desertion stemming.Rhizoma Alismatis sweet in the mouth, light, cold in nature, return kidney; Urinary bladder channel; Promoting diuresis to eliminate damp pathogen; It is treating stranguria to expel the heat-evil.Cortex Moutan is cold in nature, bitter in the mouth; GUIXIN, liver, kidney, lung meridian; Clearing away heat and cooling blood; Promoting blood circulation to remove blood stasis.Poria is sweet light, and is flat, goes into the heart, spleen, lung meridian; Eliminating dampness and diuresis, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.The acid of Radix Achyranthis Bidentatae sweetness and bitterness, flat, go into liver, kidney channel; Dissipating blood stasis blood, subduing inflammation.Semen Plantaginis is sweet, and is cold, goes into kidney, urinary bladder channel; Diuretic, heat clearing away, is eliminated the phlegm at tomorrow.The Herba Asari suffering, temperature is gone into lung, kidney channel; Dispel the wind, cold expelling, row water is had one's ideas straightened out.The Radix Scrophulariae hardship is salty, and lung, kidney channel are gone in cold; YIN nourishing, pathogenic fire reducing, relieving restlessness, detoxifcation.Rhizoma Dioscoreae is sweet, and is flat, goes into lung, spleen, kidney channel; Spleen invigorating, tonifying the lung is reinforced the kidney, and benefit is smart.
The toothache reason is a lot of, must determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs.Kidney governing bones is after the tooth person bone.If insufficiency of kidney-YANG in the kidney, hyperactivity of deficient fire causes YIN-cold and solely contains in down, and asthenic fire is floating more due to last.This toothache waits disease, be feature with two foot being sickly cold such as ice all.Square Radix Aconiti Lateralis Preparata with hot Wen Dare, the Cortex Cinnamomi of the big heat of sweet suffering, hot using warming therapy Herba Asaris etc. are gone into few cloudy with the kidney warming benefit fire; More go into to control the Radix Scrophulariae of the fire that unrooted swims, the descending Radix Achyranthis Bidentatae of igniting, Semen Plantaginis add in the LIUWEI DIHUANG TANG, mend the kidney-yang and part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels YIN-cold of dispelling of the gate of vitality, the asthenic fire of swimming that nourishing the liver and kidney is Kidney-Yin and diffusing, YIN nourishing and sun, and the effect of playing guiding fire to origin.All genus excess of YIN is in following, and on asthenic fire floated on, the nothing of using was not imitated.
Flos Rosae Rugosae regulate the flow of vital energy resolving depression and blood dissipating blood stasis; The CitrusaurantiumL.Var.amara Engl. the chest stuffiness relieving of regulating the flow of vital energy, dispersing the stagnated liver-QI for regulating the stomach, appetizing preventing or arresting vomiting.Two medicines, 5 usefulness, a gas one blood, QI and blood is two transfers, eliminating turbid pathogen with aromatics, the appetizing of being amusing, the strength enhancing that absorbs the drug when oral.Content is the edible ethanol blood circulation promoting and blood stasis dispelling more than 95%, promotes that drug osmotic to cell absorbs, and auxiliary taste absorb to improve curative effect when oral; Outer time spent skin expansion pore is to strengthen the drug transdermal trap.
Medicine of the present invention can also be coated with cheek with medicine of the present invention except for oral administration, and the efficacy of a drug sick institute that goes directly so can remove the patient suffering, obtains and imitates in no time.This medicine is applicable to that also whole body smears.Adopt oral administration and externally usedly, drug effect is more remarkable.
It is obvious that the present invention treats the toothache curative effect, and clinical usefulness repeatly, effect are very prompt.General clothes promptly obtain recovery from illness for about 10 doses.Medicine of the present invention is through clinical 100 routine patients' clinical verification, and curing number is 80 examples, and significant figure is 18 examples, and invalid number is 2 examples, and total effective rate reaches 98%.Do not see toxic side effect in the therapeutic process, the patient has better curative effect to obstinate.
For further specifying therapeutic effect, it is as follows now to enumerate model case:
Case 1: certain man 49 years old, often toothache increases the weight of when meeting stimulation such as hot and cold, acid.Oral medicine of the present invention, each 10 milliliters, every day 3 times, above symptom was alleviated in 2 days, eliminated in 5 days.Paying a return visit after 12 months does not have recurrence.
Case 2: certain man 54 years old, suffer from dental caries, often toothache.Once took the Chinese medicine of multiple treatment toothache, but effect is all not good.External medicine of the present invention is smeared whole body and cheek, and every day 2 times, each 10 milliliters, repeatedly smear at the cheek place.Above symptom was alleviated the same day, eliminated in 4 days.Paying a return visit after 12 months does not have recurrence.
Case 3: certain woman 48 years old, suffer from apicitis, the persistence toothache.Once took the Chinese medicine of multiple treatment toothache, but effect is all not good.Oral medicine of the present invention, each 10 milliliters, every day 3 times; This medicine of external is smeared whole body and cheek, and every day 2 times, each 10 milliliters, repeatedly smear at the cheek place.Above symptom is oral, and each alleviated after 1 time in 1 hour with external, eliminated in 3 days.Paying a return visit after 12 months does not have recurrence.
The specific embodiment
Embodiment 1
Take by weighing 15 parts of Flos Rosae Rugosaes, 18 parts of CitrusaurantiumL.Var.amara Engl.s, 15 parts of cinnamon powders, 16 parts in Radix Rehmanniae Preparata, 16 parts of RADIX ACONITILATERALIS PREPARATA, 16 parts of Fructus Corni, 17 parts of Rhizoma Alismatis, 17 parts of Cortex Moutans, 17 parts in Poria, 18 parts of Radix Achyranthis Bidentataes, 18 parts of Semen Plantaginiss, 18 parts of Herba Asaris, 19 parts of Radix Scrophulariaes, 20 parts of Rhizoma Dioscoreaes adopt the method that decocts the back concentrating under reduced pressure to make Chinese medicine extract respectively, and are standby.
Under the room temperature, get the deionized water of 5 ~ 6 times of amounts, add content and be 18 parts of 96% edible ethanols, be mixed with aqueous solution of alcohol, standby.
Above-mentioned various Chinese medicine extract are added in the aqueous solution of alcohol, fully stirred 120 minutes, precipitate 2 ~ 4 hours, supernatant 200 orders filter, and the medicine that gained filtrate is the treatment toothache of oral administration or external carries out fill under aseptic condition.Gained precipitate and filtering residue focus on.
Embodiment 2
The drug component proportioning is: 18 parts of Flos Rosae Rugosaes, 19 parts of CitrusaurantiumL.Var.amara Engl.s, 19 parts of cinnamon powders, 19 parts in Radix Rehmanniae Preparata, 20 parts of RADIX ACONITILATERALIS PREPARATA, 18 parts of Fructus Corni, 20 parts of Rhizoma Alismatis, 19 parts of Cortex Moutans, 18 parts in Poria, 20 parts of Radix Achyranthis Bidentataes, 20 parts of Semen Plantaginiss, 19 parts of Herba Asaris, 20 parts of Radix Scrophulariaes, 19 parts of Rhizoma Dioscoreaes, content is 18 parts of 97% edible ethanols.Other is identical with embodiment 1.
Embodiment 3
The drug component proportioning is: 19 parts of Flos Rosae Rugosaes, 20 parts of CitrusaurantiumL.Var.amara Engl.s, 20 parts of cinnamon powders, 20 parts in Radix Rehmanniae Preparata, 20 parts of RADIX ACONITILATERALIS PREPARATA, 20 parts of Fructus Corni, 19 parts of Rhizoma Alismatis, 20 parts of Cortex Moutans, 19 parts in Poria, 19 parts of Radix Achyranthis Bidentataes, 19 parts of Semen Plantaginiss, 19 parts of Herba Asaris, 20 parts of Radix Scrophulariaes, 20 parts of Rhizoma Dioscoreaes, content is 18 parts of 98% edible ethanols.Other is identical with embodiment 1.
Claims (5)
1. a medicine for the treatment of toothache is characterized in that it mainly is to be made by the raw material of following weight portion: 1 ~ 20 part of Flos Rosae Rugosae, 1 ~ 20 part of CitrusaurantiumL.Var.amara Engl., 1 ~ 20 part of cinnamon powder, 1 ~ 20 part in Radix Rehmanniae Preparata, 1 ~ 20 part of RADIX ACONITILATERALIS PREPARATA, 1 ~ 20 part of Fructus Corni, 1 ~ 20 part of Rhizoma Alismatis, 1 ~ 20 part of Cortex Moutan, 1 ~ 20 part in Poria, 1 ~ 20 part of Radix Achyranthis Bidentatae, 1 ~ 20 part of Semen Plantaginis, 1 ~ 20 part of Herba Asari, 1 ~ 20 part of Radix Scrophulariae, 1 ~ 20 part of Rhizoma Dioscoreae, content is 1 ~ 20 part of edible ethanol more than 95%.
2. medicine as claimed in claim 1 is characterized in that it mainly is to be made by the raw material of following weight portion: 15 ~ 20 parts of Flos Rosae Rugosaes, 15 ~ 20 parts of CitrusaurantiumL.Var.amara Engl.s, 15 ~ 20 parts of cinnamon powders, 15 ~ 20 parts in Radix Rehmanniae Preparata, 15 ~ 20 parts of RADIX ACONITILATERALIS PREPARATA, 15 ~ 20 parts of Fructus Corni, 15 ~ 20 parts of Rhizoma Alismatis, 15 ~ 20 parts of Cortex Moutans, 15 ~ 20 parts in Poria, 15 ~ 20 parts of Radix Achyranthis Bidentataes, 15 ~ 20 parts of Semen Plantaginiss, 15 ~ 20 parts of Herba Asaris, 15 ~ 20 parts of Radix Scrophulariaes, 15 ~ 20 parts of Rhizoma Dioscoreaes, content is 15 ~ 20 parts of edible ethanols more than 95%.
3. medicine as claimed in claim 1 or 2 is characterized in that described medicine comprises that also weight portion is 1 ~ 5 part a azone.
4. the preparation method of the described medicine of one of claim 1 to 3 is characterized in that comprising the following steps:
A) take by weighing Flos Rosae Rugosae, CitrusaurantiumL.Var.amara Engl., cinnamon powder, Radix Rehmanniae Preparata, RADIX ACONITILATERALIS PREPARATA, Fructus Corni, Rhizoma Alismatis, Cortex Moutan, Poria, Radix Achyranthis Bidentatae, Semen Plantaginis, Herba Asari, Radix Scrophulariae and the Rhizoma Dioscoreae of described weight proportion, according to the conventional extracting method of Chinese medicine, the extract of the former medicine that obtains respectively respectively to distinguish the flavor of;
B) under the room temperature, get the deionized water of 5 ~ 6 times of amounts, the content that adds described weight proportion is the edible ethanol more than 95%, is mixed with aqueous solution of alcohol;
C) with in the above-mentioned aqueous solution of alcohol of the extract obtained adding of step a, stirred 120 minutes, precipitate 2 ~ 4 hours, filter, gained filtrate sterilization, fill according to quantity must be treated the medicine of toothache.
5. preparation method as claimed in claim 4 is characterized in that, among the step c, azone step a is extract obtained and described weight proportion adds aqueous solution of alcohol together.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010102649333A CN101987156B (en) | 2010-08-27 | 2010-08-27 | Medicine for treating toothache and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN2010102649333A CN101987156B (en) | 2010-08-27 | 2010-08-27 | Medicine for treating toothache and preparation method thereof |
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| CN101987156A true CN101987156A (en) | 2011-03-23 |
| CN101987156B CN101987156B (en) | 2012-08-29 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104173758A (en) * | 2014-08-15 | 2014-12-03 | 徐静 | Traditional Chinese medicine for treating toothache |
| CN104189632A (en) * | 2014-08-14 | 2014-12-10 | 卓永松 | Traditional Chinese medicine prescription for treating periodontal disease |
| CN111617178A (en) * | 2020-06-22 | 2020-09-04 | 邬高华 | Tooth-strengthening analgesic and preparation method thereof |
-
2010
- 2010-08-27 CN CN2010102649333A patent/CN101987156B/en not_active Expired - Fee Related
Non-Patent Citations (3)
| Title |
|---|
| 《中药大辞典》 20060331 南京中医药大学 玫瑰花；玳玳花 上海科学技术出版社 1745-1748，2098 1-5 , 1 * |
| 《中药药剂学》 20020131 张兆旺，等 中药合剂（含口服液）；渗透促进剂 中国中医药出版社 103-105，185-187 1-5 , 1 * |
| 《秘方求真》 20030531 程爵棠，等 虚火牙痛汤 学苑出版社 912 1-5 , 1 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104189632A (en) * | 2014-08-14 | 2014-12-10 | 卓永松 | Traditional Chinese medicine prescription for treating periodontal disease |
| CN104189632B (en) * | 2014-08-14 | 2017-11-17 | 卓培玲 | A kind of Chinese medicine composition for treating periodontosis |
| CN104173758A (en) * | 2014-08-15 | 2014-12-03 | 徐静 | Traditional Chinese medicine for treating toothache |
| CN111617178A (en) * | 2020-06-22 | 2020-09-04 | 邬高华 | Tooth-strengthening analgesic and preparation method thereof |
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| Publication number | Publication date |
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| CN101987156B (en) | 2012-08-29 |
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