CN105125904A - Pharmaceutical composition for treating cerebral hemorrhage - Google Patents
Pharmaceutical composition for treating cerebral hemorrhage Download PDFInfo
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- CN105125904A CN105125904A CN201510531980.2A CN201510531980A CN105125904A CN 105125904 A CN105125904 A CN 105125904A CN 201510531980 A CN201510531980 A CN 201510531980A CN 105125904 A CN105125904 A CN 105125904A
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Abstract
The invention relates to a pharmaceutical composition for treating cerebral hemorrhage, wherein the pharmaceutical composition is prepared from the following medicinal raw materials in parts by weight: 15-25 parts of bamboo shavings, 15-25 parts of loofah sponge, 10-15 parts of selfheal, 10-15 parts of caulis spatholobi, 10-15 parts of gynostemma pentaphylla, 10-15 parts of codonopsis pilosula, 10-15 parts of capillary artemisia, 5-10 parts of eucommia bark, 5-10 parts of folium ginkgo, 5-10 parts of teasel root, 5-10 parts of cassia twig, 5-10 parts of hippophae rhamnoides and 5-10 parts of common andrographis herb. The traditional Chinese medicinal composition has functions of promoting blood circulation to remove blood stasis, removing phlegm and eliminating stagnation, tonifying middle-Jiao and Qi, clearing and activating channels and collaterals, clearing heat and dissipating phlegm; and clinical application shows that the pharmaceutical composition is concrete in curative effect, convenient to take, rapid to take effect, free from toxic or side effect and is capable of preventing and treating cerebral hemorrhage.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition, in particular to the pharmaceutical composition for the treatment of cerebral hemorrhage.
Background technology
Cerebral hemorrhage is also called cerebral hemorrhage, refer in brain essence have relatively large hemorrhage.The cerebral hemorrhage of about 70% to 80% is due to the tiny arteriosclerosis of hypertension, occurs caused by angiorrhexis because blood pressure rises sharply.In acute cerebrovascular disease, cerebral hemorrhage accounts for 10% to 20%.The case fatality rate of primary disease is about 40% to 70%.Hypertension and arteriosclerosis are the principal elements of cerebral hemorrhage, also can by congenital cerebral aneurysm, cerebrovascular malformation, cerebroma, hematopathy, infection, medicine, outward injure poisoning etc. caused by.When possessing the patient of above-mentioned change, once under excited, the muscle power inducement such as excessive, when occurring that blood pressure sharply increases to over the pressure that its blood vessel wall can bear, blood vessel will Rupture haemorrhag, forms the hemorrhagic focus varied in size in brain.Primary disease is more common in the middle-aged and elderly people of hypertension history and more than 50 years old.How excited, work or movable and sudden and violent cold time morbidity, minority can occur in rest or sleep.Cold season is multiple.
Western medicine cerebral hemorrhage has rapid-action, treats advantage with strong points, is used for acute stages treated, the shortcoming of Western medicine is that action target spot is single, so for apoplexy sequela patient, only have treatment by Chinese herbs, efficacy enhancing and toxicity reducing can be reached, the therapeutic effect for the treatment of both the principal and secondary aspects of a disease.
The traditional Chinese medical science is thought, cerebral hemorrhage is the category of apoplexy, because patient's function weakness causes body constitution partially empty, run into again extraneous factor effect, such as seven emotions (pleasure, anger, sorrow, happiness, compassion, think of, probably) or six climate exopathogens (wind, cold, summer-heat, wet, dry, fiery), and eating and drinking too much at one meal etc., cause in exopathogenic factor priming, thus causing the turbid congestion of expectorant, meridians become silted up and hinder, and blood circulating away from normal passage, superinverse causes in head.According to theory of Chinese medical science, for the pathogeny of cerebral hemorrhage, carry out dialectical composition of prescription, to reach the object for the treatment of both the principal and secondary aspects of a disease.
Summary of the invention
The invention provides a kind of pharmaceutical composition for the treatment of cerebral hemorrhage, based on the dialectical prescription of tcm theory, there is blood circulation promoting and blood stasis dispelling, open effect of expectorant dissipating blood stasis, invigorating the spleen and replenishing QI, dredge the meridian passage, removing heat-phlegm, clinical practice shows, this pharmaceutical composition determined curative effect, taking convenience, instant effect, have no side effect, can prevention and therapy cerebral hemorrhage.
Concrete, one aspect of the present invention provides a kind of pharmaceutical composition for the treatment of cerebral hemorrhage, is made up of the crude drug of following weight portion: Caulis Bambusae In Taenia 15-25 part, Retinervus Luffae Fructus 15-25 part.
In the embodiment that the present invention one is concrete, the pharmaceutical composition of described treatment cerebral hemorrhage, is made up of the crude drug of following weight portion: Caulis Bambusae In Taenia 15-25 part, Retinervus Luffae Fructus 15-25 part, Spica Prunellae 10-15 part, Caulis Spatholobi 10-15 part.
In the embodiment that the present invention one is concrete, the pharmaceutical composition of described treatment cerebral hemorrhage, is made up of the crude drug of following weight portion: Caulis Bambusae In Taenia 15-25 part, Retinervus Luffae Fructus 15-25 part, Spica Prunellae 10-15 part, Caulis Spatholobi 10-15 part, Herb Gynostemmae Pentaphylli 10-15 part, Radix Codonopsis 10-15 part, Herba Artemisiae Scopariae 10-15 part, Cortex Eucommiae 5-10 part, Folium Ginkgo 5-10 part, Radix Dipsaci 5-10 part, Ramulus Cinnamomi 5-10 part, Fructus Hippophae 5-10 part, Herba Andrographis 5-10 part.
In the embodiment that the present invention one is concrete, the pharmaceutical composition of described treatment cerebral hemorrhage, is made up of the crude drug of following weight portion: Caulis Bambusae In Taenia 15 parts, Retinervus Luffae Fructus 15 parts, Spica Prunellae 10 parts, Caulis Spatholobi 10 parts, Herb Gynostemmae Pentaphylli 10 parts, Radix Codonopsis 10 parts, Herba Artemisiae Scopariae 10 parts, the Cortex Eucommiae 5 parts, Folium Ginkgo 5 parts, Radix Dipsaci 5 parts, Ramulus Cinnamomi 5 parts, Fructus Hippophae 5 parts, Herba Andrographis 5 parts.
In the embodiment that the present invention one is concrete, the pharmaceutical composition of described treatment cerebral hemorrhage, is made up of the crude drug of following weight portion: Caulis Bambusae In Taenia 25 parts, Retinervus Luffae Fructus 25 parts, Spica Prunellae 15 parts, Caulis Spatholobi 15 parts, Herb Gynostemmae Pentaphylli 15 parts, Radix Codonopsis 15 parts, Herba Artemisiae Scopariae 15 parts, the Cortex Eucommiae 10 parts, Folium Ginkgo 10 parts, Radix Dipsaci 10 parts, Ramulus Cinnamomi 10 parts, Fructus Hippophae 10 parts, Herba Andrographis 10 parts.
In the embodiment that the present invention one is concrete, the pharmaceutical composition of described treatment cerebral hemorrhage, is made up of the crude drug of following weight portion: Caulis Bambusae In Taenia 15 parts, Retinervus Luffae Fructus 25 parts, Spica Prunellae 10 parts, Caulis Spatholobi 15 parts, Herb Gynostemmae Pentaphylli 10 parts, Radix Codonopsis 15 parts, Herba Artemisiae Scopariae 10 parts, the Cortex Eucommiae 10 parts, Folium Ginkgo 5 parts, Radix Dipsaci 10 parts, Ramulus Cinnamomi 5 parts, Fructus Hippophae 10 parts, Herba Andrographis 5 parts.
In the embodiment that the present invention one is concrete, the pharmaceutical composition of described treatment cerebral hemorrhage, is made up of the crude drug of following weight portion: Caulis Bambusae In Taenia 20 parts, Retinervus Luffae Fructus 22 parts, Spica Prunellae 12 parts, Caulis Spatholobi 13 parts, Herb Gynostemmae Pentaphylli 12 parts, Radix Codonopsis 11 parts, Herba Artemisiae Scopariae 14 parts, the Cortex Eucommiae 6 parts, Folium Ginkgo 9 parts, Radix Dipsaci 7 parts, Ramulus Cinnamomi 6 parts, Fructus Hippophae 8 parts, Herba Andrographis 9 parts.
In the embodiment that the present invention one is concrete, the pharmaceutical composition of described treatment cerebral hemorrhage, is made up of the crude drug of following weight portion: Caulis Bambusae In Taenia 24 parts, Retinervus Luffae Fructus 17 parts, Spica Prunellae 14 parts, Caulis Spatholobi 13 parts, Herb Gynostemmae Pentaphylli 12 parts, Radix Codonopsis 13 parts, Herba Artemisiae Scopariae 12 parts, the Cortex Eucommiae 9 parts, Folium Ginkgo 6 parts, Radix Dipsaci 9 parts, Ramulus Cinnamomi 8 parts, Fructus Hippophae 7 parts, Herba Andrographis 8 parts.
The present invention relates to a kind of preparation method for the treatment of the pharmaceutical composition of cerebral hemorrhage on the other hand, and the preparation method of this Chinese medicine composition comprises the following steps:
(1) Retinervus Luffae Fructus, Spica Prunellae, Herb Gynostemmae Pentaphylli, Radix Codonopsis, Radix Dipsaci, Fructus Hippophae are added soak by water 2-3 time accounting for gross weight 8-15 times amount, each 1.5-2 hour, collecting decoction, then add the aqueous solution that step (1) obtains, filter, obtain filtrate;
(2) Caulis Bambusae In Taenia, Caulis Spatholobi, Herba Artemisiae Scopariae, the Cortex Eucommiae, Folium Ginkgo, Ramulus Cinnamomi, Herba Andrographis are added account for gross weight 8-15 times amount 85% alcoholic solution in extract 2-3 time, each 2-3 hour, filter, merging filtrate, placement is spent the night, and reclaims ethanol and obtains filtrate;
(3) in step (1), the mixing of (2) gained filtrate.
Preferably, the soak by water 3 times accounting for gross weight 10 times amount is wherein added in step (1), each 1.5 hours; Account in step (2) in the alcoholic solution of 85% of gross weight 10 times amount and extract 2 times, each 3 hours.
Pharmaceutical composition of the present invention can also be prepared according to the conventional method of the field of Chinese medicines, comprises soak by water etc.The pharmaceutical composition for the treatment of cerebral hemorrhage of the present invention, adopts the conventional method of Chinese medicine preparation to be prepared into any traditional oral preparation.Described oral formulations is capsule, pill, powder, tablet, granule.
The present invention treats the pharmaceutical composition of cerebral hemorrhage, based on the dialectical prescription of tcm theory, there is blood circulation promoting and blood stasis dispelling, open effect of expectorant dissipating blood stasis, invigorating the spleen and replenishing QI, dredge the meridian passage, removing heat-phlegm, clinical practice shows, this pharmaceutical composition determined curative effect, taking convenience, instant effect, have no side effect, can prevention and therapy cerebral hemorrhage.
Detailed description of the invention
Embodiment 1:
Treat a pharmaceutical composition for cerebral hemorrhage, be made up of the crude drug of following weight portion: Caulis Bambusae In Taenia 15 parts, Retinervus Luffae Fructus 15 parts, Spica Prunellae 10 parts, Caulis Spatholobi 10 parts, Herb Gynostemmae Pentaphylli 10 parts, Radix Codonopsis 10 parts, Herba Artemisiae Scopariae 10 parts, the Cortex Eucommiae 5 parts, Folium Ginkgo 5 parts, Radix Dipsaci 5 parts, Ramulus Cinnamomi 5 parts, Fructus Hippophae 5 parts, Herba Andrographis 5 parts;
Take said medicine by formula ratio, be added to the water, boil, slow fire boiling 30 minutes, filter, filtering residue adds water again, slow fire boiling 30 minutes, merge twice medicinal liquid, to obtain final product.
Embodiment 2:
Treat a pharmaceutical composition for cerebral hemorrhage, be made up of the crude drug of following weight portion: Caulis Bambusae In Taenia 15 parts, Retinervus Luffae Fructus 15 parts, Spica Prunellae 10 parts, Caulis Spatholobi 10 parts, Herb Gynostemmae Pentaphylli 10 parts, Radix Codonopsis 10 parts, Herba Artemisiae Scopariae 10 parts, the Cortex Eucommiae 5 parts, Folium Ginkgo 5 parts, Radix Dipsaci 5 parts, Ramulus Cinnamomi 5 parts, Fructus Hippophae 5 parts, Herba Andrographis 5 parts;
Preparation method comprises the following steps:
(1) Retinervus Luffae Fructus, Spica Prunellae, Herb Gynostemmae Pentaphylli, Radix Codonopsis, Radix Dipsaci, Fructus Hippophae are added the soak by water 2 times accounting for gross weight 15 times amount, each 2 hours, collecting decoction, then add the aqueous solution that step (1) obtains, filter, obtain filtrate;
(2) Caulis Bambusae In Taenia, Caulis Spatholobi, Herba Artemisiae Scopariae, the Cortex Eucommiae, Folium Ginkgo, Ramulus Cinnamomi, Herba Andrographis are added account for gross weight 8 times amount 85% alcoholic solution in extract 3 times, each 3 hours, filter, merging filtrate, placement was spent the night, and reclaimed ethanol and obtained filtrate;
(3) in step (1), the mixing of (2) gained filtrate.
Embodiment 3:
Treat a pharmaceutical composition for cerebral hemorrhage, be made up of the crude drug of following weight portion: Caulis Bambusae In Taenia 25 parts, Retinervus Luffae Fructus 25 parts, Spica Prunellae 15 parts, Caulis Spatholobi 15 parts, Herb Gynostemmae Pentaphylli 15 parts, Radix Codonopsis 15 parts, Herba Artemisiae Scopariae 15 parts, the Cortex Eucommiae 10 parts, Folium Ginkgo 10 parts, Radix Dipsaci 10 parts, Ramulus Cinnamomi 10 parts, Fructus Hippophae 10 parts, Herba Andrographis 10 parts;
Preparation method comprises the following steps:
(1) Retinervus Luffae Fructus, Spica Prunellae, Herb Gynostemmae Pentaphylli, Radix Codonopsis, Radix Dipsaci, Fructus Hippophae are added the soak by water 3 times accounting for gross weight 8 times amount, each 2 hours, collecting decoction, then add the aqueous solution that step (1) obtains, filter, obtain filtrate;
(2) Caulis Bambusae In Taenia, Caulis Spatholobi, Herba Artemisiae Scopariae, the Cortex Eucommiae, Folium Ginkgo, Ramulus Cinnamomi, Herba Andrographis are added account for gross weight 15 times amount 85% alcoholic solution in extract 2 times, each 3 hours, filter, merging filtrate, placement was spent the night, and reclaimed ethanol and obtained filtrate;
(3) in step (1), the mixing of (2) gained filtrate.
Embodiment 4:
Treat a pharmaceutical composition for cerebral hemorrhage, be made up of the crude drug of following weight portion: Caulis Bambusae In Taenia 15 parts, Retinervus Luffae Fructus 25 parts, Spica Prunellae 10 parts, Caulis Spatholobi 15 parts, Herb Gynostemmae Pentaphylli 10 parts, Radix Codonopsis 15 parts, Herba Artemisiae Scopariae 10 parts, the Cortex Eucommiae 10 parts, Folium Ginkgo 5 parts, Radix Dipsaci 10 parts, Ramulus Cinnamomi 5 parts, Fructus Hippophae 10 parts, Herba Andrographis 5 parts;
Take said medicine by formula ratio, be added to the water, boil, slow fire boiling 30 minutes, filter, filtering residue adds water again, slow fire boiling 30 minutes, merge twice medicinal liquid, to obtain final product.
Embodiment 5:
Treat a pharmaceutical composition for cerebral hemorrhage, be made up of the crude drug of following weight portion: Caulis Bambusae In Taenia 20 parts, Retinervus Luffae Fructus 22 parts, Spica Prunellae 12 parts, Caulis Spatholobi 13 parts, Herb Gynostemmae Pentaphylli 12 parts, Radix Codonopsis 11 parts, Herba Artemisiae Scopariae 14 parts, the Cortex Eucommiae 6 parts, Folium Ginkgo 9 parts, Radix Dipsaci 7 parts, Ramulus Cinnamomi 6 parts, Fructus Hippophae 8 parts, Herba Andrographis 9 parts.
Take said medicine by formula ratio, be added to the water, boil, slow fire boiling 30 minutes, filter, filtering residue adds water again, slow fire boiling 30 minutes, merge twice medicinal liquid, to obtain final product.
Embodiment 6:
Treat a pharmaceutical composition for cerebral hemorrhage, be made up of the crude drug of following weight portion: Caulis Bambusae In Taenia 24 parts, Retinervus Luffae Fructus 17 parts, Spica Prunellae 14 parts, Caulis Spatholobi 13 parts, Herb Gynostemmae Pentaphylli 12 parts, Radix Codonopsis 13 parts, Herba Artemisiae Scopariae 12 parts, the Cortex Eucommiae 9 parts, Folium Ginkgo 6 parts, Radix Dipsaci 9 parts, Ramulus Cinnamomi 8 parts, Fructus Hippophae 7 parts, Herba Andrographis 8 parts.
Take said medicine by formula ratio, be added to the water, boil, slow fire boiling 30 minutes, filter, filtering residue adds water again, slow fire boiling 30 minutes, merge twice medicinal liquid, to obtain final product.
Embodiment 7: clinical data
1, physical data
Clinical choose through Cranial Computed Tomography or MRI check make a definite diagnosis patients with cerebral hemorrhage 100 example, wherein 45-60 year 45 example, 60-75 year 55 example.
2, usage and dosage: during clinical practice, the amounts of components in compositions takes the circumstances into consideration increase and decrease according to the body weight of patient and age.One day potion, decocting twice extracting juice is about 300ml, and point morning, evening take for twice.It within 7 days, is a course for the treatment of.
3, curative effect judging standard
(1) fully recover: sings and symptoms disappears or substantially disappears, and substantially can live on one's own life;
(2) effective: symptom and sign take a turn for the better, the action of energy cane, or basic living can be taken care of oneself;
(3) effective: symptom and sign take a turn for the better to some extent, substantially can hold up battle action;
(4) invalid; Sings and symptoms is all not improved, and symptom is as front.
4, therapeutic outcome:
Result after 6 courses for the treatment of: clinical recovery 31 people; Effective 42 people; Effective 20 people, invalid 7 people; The present invention is 97% to cerebral hemorrhage total effective rate.
Model case
Liu, man, 59 years old.Cardinal symptom: dizziness, slurred speech, poor memory, left hemianesthesia, left lower limb is sent out directly, left hand is dumb, cannot independent ambulation.Laboratory examination result is cerebral hemorrhage.Take 3 courses for the treatment of of medicament prepared by Chinese medicine composition of the present invention, symptom disappears substantially; Continue to take 3 courses for the treatment of, symptom disappears completely, and life is supported oneself.
Guo, man, 64 years old, patient's sudden onset, conscious left hand, foot active receiving limit, and health is numb, stiff, hemiplegia, cannot independent ambulation; Seek medical advice everywhere, it is invalid to control for a long time.After taking 3 courses for the treatment of of Drug therapy of the present invention, left hand, foot activity are nimble, can walk down; Continue to take 3 courses for the treatment of, symptom disappears completely, cures.
Korea Spro, female, 56 years old.Sudden onset, with the paralysis of dizziness headache, slurred speech, the loss of memory, distortion of commissure and half body, can not stand.Examine as cerebral hemorrhage.Take 3 courses for the treatment of of medicament prepared by Chinese medicine composition of the present invention, symptom is eased; Continue to take 3 courses for the treatment of, symptom disappears completely, cures.
Claims (8)
1. treat a pharmaceutical composition for cerebral hemorrhage, it is characterized in that, be made up of the crude drug of following weight portion: Caulis Bambusae In Taenia 15-25 part, Retinervus Luffae Fructus 15-25 part.
2. the pharmaceutical composition for the treatment of cerebral hemorrhage according to claim 1, is made up of the crude drug of following weight portion: Caulis Bambusae In Taenia 15-25 part, Retinervus Luffae Fructus 15-25 part, Spica Prunellae 10-15 part, Caulis Spatholobi 10-15 part.
3. the pharmaceutical composition for the treatment of cerebral hemorrhage according to claim 1, is made up of the crude drug of following weight portion: Caulis Bambusae In Taenia 15-25 part, Retinervus Luffae Fructus 15-25 part, Spica Prunellae 10-15 part, Caulis Spatholobi 10-15 part, Herb Gynostemmae Pentaphylli 10-15 part, Radix Codonopsis 10-15 part, Herba Artemisiae Scopariae 10-15 part, Cortex Eucommiae 5-10 part, Folium Ginkgo 5-10 part, Radix Dipsaci 5-10 part, Ramulus Cinnamomi 5-10 part, Fructus Hippophae 5-10 part, Herba Andrographis 5-10 part.
4. the pharmaceutical composition for the treatment of cerebral hemorrhage according to claim 1, is made up of the crude drug of following weight portion: Caulis Bambusae In Taenia 15 parts, Retinervus Luffae Fructus 15 parts, Spica Prunellae 10 parts, Caulis Spatholobi 10 parts, Herb Gynostemmae Pentaphylli 10 parts, Radix Codonopsis 10 parts, Herba Artemisiae Scopariae 10 parts, the Cortex Eucommiae 5 parts, Folium Ginkgo 5 parts, Radix Dipsaci 5 parts, Ramulus Cinnamomi 5 parts, Fructus Hippophae 5 parts, Herba Andrographis 5 parts.
5. the pharmaceutical composition for the treatment of cerebral hemorrhage according to claim 1, is made up of the crude drug of following weight portion: Caulis Bambusae In Taenia 25 parts, Retinervus Luffae Fructus 25 parts, Spica Prunellae 15 parts, Caulis Spatholobi 15 parts, Herb Gynostemmae Pentaphylli 15 parts, Radix Codonopsis 15 parts, Herba Artemisiae Scopariae 15 parts, the Cortex Eucommiae 10 parts, Folium Ginkgo 10 parts, Radix Dipsaci 10 parts, Ramulus Cinnamomi 10 parts, Fructus Hippophae 10 parts, Herba Andrographis 10 parts.
6. the pharmaceutical composition for the treatment of cerebral hemorrhage according to claim 1, is made up of the crude drug of following weight portion: Caulis Bambusae In Taenia 15 parts, Retinervus Luffae Fructus 25 parts, Spica Prunellae 10 parts, Caulis Spatholobi 15 parts, Herb Gynostemmae Pentaphylli 10 parts, Radix Codonopsis 15 parts, Herba Artemisiae Scopariae 10 parts, the Cortex Eucommiae 10 parts, Folium Ginkgo 5 parts, Radix Dipsaci 10 parts, Ramulus Cinnamomi 5 parts, Fructus Hippophae 10 parts, Herba Andrographis 5 parts.
7. the pharmaceutical composition of the treatment cerebral hemorrhage described in any one of claim 1-6, is characterized in that, adopts the conventional method of Chinese medicine preparation to be prepared into any traditional oral preparation.
8. the pharmaceutical composition for the treatment of cerebral hemorrhage according to claim 7, is characterized in that, described oral formulations is oral liquid, capsule, pill, powder, tablet, granule.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107684595A (en) * | 2017-09-28 | 2018-02-13 | 新乡市中心医院 | A kind of Chinese medicine composition for treating Neurology cerebral hemorrhage and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103705789A (en) * | 2014-01-14 | 2014-04-09 | 庄成龙 | Pharmaceutical composition for treating cerebral hemorrhage |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103705789A (en) * | 2014-01-14 | 2014-04-09 | 庄成龙 | Pharmaceutical composition for treating cerebral hemorrhage |
Non-Patent Citations (2)
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| 杨卫平 等主编: "《新编中草药图谱及经典配方.2》", 31 May 2014 * |
| 马康孝 编著: "《脑出血的诊治及新进展》", 31 May 2013 * |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107684595A (en) * | 2017-09-28 | 2018-02-13 | 新乡市中心医院 | A kind of Chinese medicine composition for treating Neurology cerebral hemorrhage and preparation method thereof |
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