CN103099914B - Traditional Chinese medicine composition for treating acute pancreatitis - Google Patents
Traditional Chinese medicine composition for treating acute pancreatitis Download PDFInfo
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- CN103099914B CN103099914B CN201310051593.XA CN201310051593A CN103099914B CN 103099914 B CN103099914 B CN 103099914B CN 201310051593 A CN201310051593 A CN 201310051593A CN 103099914 B CN103099914 B CN 103099914B
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Abstract
The invention discloses a traditional Chinese medicine composition for treating acute pancreatitis, which comprises the following raw materials by weight: 5-10 parts of rheum officinale, 5-10 parts of saltcake, 6-12 parts of bitter orange, 9-15 parts of magnolia cortex, 5-10 parts of red sage root, 5-10 parts of ligustrazine, 5-10 parts of breviscapinun, 5-10 parts of Artemisia capillaries, 5-10 parts of gentrin knotweed, 10-20 parts of radix bupleuri, 10-20 parts of gentian, 10-20 parts of pinellia ternate, 5-10 parts of white peony root, 2-6 parts of root of large-flowered skullcap, 2-6 parts of cape jasmine, 5-10 parts of ginkgo biloba, 2-6 parts of acanthopanax and 2-6 parts of rutin. According to the traditional Chinese medicine composition, the selected raw materials are natural, the compatibility is scientific, the ache can be quickly relieved, the abdominal distension is eliminated, the inflammation is reduced, the traditional Chinese medicine composition has obvious curative effect for treating pancreatitis, no toxic and side effect can be generated, the clinical practice verifies that the treatment effect is obvious, the mortality is greatly reduced, and the cure rate is enhanced.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, particularly relate to a kind of Chinese medicine composition for the treatment of acute pancreatitis.
Background technology
Acute pancreatitis is a kind of increasing suddenly because pancreatemphraxis, ductus pancreaticus are intrinsic pressure and the pancreas acute inflammation that reason causes such as pancreas blood is under-supply.Clinical manifestation mainly contains upper abdominal pain, and nausea and vomiting and abdominal distention, and have a medical check-up and can have epigastrium tenderness, hypoactive bowel sounds or disappearance, blood, amylase in urine raise.About half patient is with biliary tract.
Acute pancreatitis refers to the Acute Chemical inflammation that causes pancreatic tissue autodigestion after pancreatin is activated in pancreas.Early stage application aprotinin (a kind of tryptic inhibitor) can improve curative effect.The pancreatitis of hemorrhagic necrosis type is through medical treatment nonresponder, or merging abdominal cavity infection person can consider to do peritoneal lavage or pancreas is touched open decompression, necrotic tissue cleaning art.
Discovery pancreatitis should be treated in time, and Chinese medicine conditioning and treating is best auxiliary treatment way, can greatly improve pancreatitic cure rate and shorten recovery time.At present the Chinese medicine for the treatment of acute pancreatitis take rush down under, regulate the flow of vital energy, heat clearing away, invigorate blood circulation as main, applying maximum is Radix Et Rhizoma Rhei, applying frequency reaches more than 90%, is secondly Natrii Sulfas, Radix Bupleuri, Cortex Magnoliae Officinalis etc.Conventional prescription is: Radix Scutellariae, Flos Lonicerae, Fructus Forsythiae, Fructus Gardeniae, Fructus Aurantii Immaturus, Radix Aucklandiae (Radix Vladimiriae), Radix Et Rhizoma Rhei, Matrii Sulfas Exsiccatus etc.Food stagnation person separately adds lenitive pill; Acupuncture and ear acupuncture also can reach analgesic effect.
But the Chinese medicinal formulae for the treatment of at present acute pancreatitis is numerous and jumbled, limits it and further apply.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine composition of new treatment acute pancreatitis, be developed into external application of Chinese medicine preparation, with medicated bag form, be placed in sack for hot compression therapy, can eliminate the seroperitoneum that acute pancreatitis causes and promote the improvement of pancreas inflammatory, evident in efficacy and have no side effect.
The object of the invention to solve the technical problems realizes by the following technical solutions.A kind of Chinese medicine composition for the treatment of acute pancreatitis proposing according to the present invention, each raw material by following weight portion proportioning forms: Radix Et Rhizoma Rhei 5-10 part, Natrii Sulfas 5-10 part, Fructus Aurantii 6-12, Cortex Magnoliae Officinalis 9-15 part, Radix Salviae Miltiorrhizae 5-10 part, ligustrazine 5-10 part, breviscapine 5-10 part, Herba Artemisiae Scopariae 5-10 part, Rhizoma Polygoni Cuspidati 5-10 part, Radix Bupleuri 10-20 part, Radix Gentianae 10-20 part, Rhizoma Pinelliae 10-20 part, Radix Paeoniae Alba 5-10 part, Radix Scutellariae 2-6 part, Fructus Gardeniae 2-6 part, Folium Ginkgo 5-10 part, Radix Et Caulis Acanthopanacis Senticosi 2-6 part, rutin 2-6 part.
Furthermore, Chinese medicine composition of the present invention is comprised of each raw material of following weight portion proportioning: Radix Et Rhizoma Rhei 5-8 part, Natrii Sulfas 5-8 part, Fructus Aurantii 6-9 part, Cortex Magnoliae Officinalis 9-12 part, Radix Salviae Miltiorrhizae 5-8 part, ligustrazine 5-8 part, breviscapine 5-8 part, Herba Artemisiae Scopariae 5-8 part, Rhizoma Polygoni Cuspidati 5-8 part, Radix Bupleuri 10-15 part, Radix Gentianae 10-15 part, Rhizoma Pinelliae 10-15 part, Radix Paeoniae Alba 5-8 part, Radix Scutellariae 2-4 part, Fructus Gardeniae 2-4 part, Folium Ginkgo 5-8 part, Radix Et Caulis Acanthopanacis Senticosi 2-4 part, rutin 2-4 part.
Furthermore, Chinese medicine composition of the present invention is comprised of each raw material of following weight portion proportioning: 5 parts of Radix Et Rhizoma Rhei, 5 parts, Natrii Sulfas, 6 parts of Fructus Aurantiis, 9 parts of Cortex Magnoliae Officinalis, 5 parts of Radix Salviae Miltiorrhizaes, 5 parts of ligustrazine, 5 parts of breviscapines, 5 parts of Herba Artemisiae Scopariaes, 5 parts of Rhizoma Polygoni Cuspidati, 10 parts of Radix Bupleuri, 10 parts of Radix Gentianaes, 10 parts of the Rhizoma Pinelliaes, 5 parts of the Radix Paeoniae Albas, 2 parts of Radix Scutellariaes, 2 parts of Fructus Gardeniaes, 5 parts of Folium Ginkgos, 2 parts of Radix Et Caulis Acanthopanacis Senticosis, 2 parts of rutins.
In addition, Chinese medicine composition its preparation method of the present invention is: smash, grind to form above-mentioned raw materials component to pieces powdery respectively, then according to the weight portion proportioning mixing and stirring of above-mentioned each composition of raw materials and get final product.
Furthermore, each raw material components formula is added respectively to water steaming and decocting, obtain extract, and can add adjuvant to carry out the preparation of preparation.
Furthermore, described accessory package, containing Fruit powder, edible essence, sweeting agent, acidic flavoring agent, filler, lubricant, antiseptic, suspending agent, food coloring, diluent and plasticizer, is made peroral dosage form.
Furthermore, Chinese medicine composition of the present invention can be made into granule, tablet, powder, injection, capsule, honeyed pill or patch.
Furthermore, the Chinese medicine composition after mixing and stirring is made to outer charging, be placed in sack.
By technique scheme, the present invention treats the advantage that the Chinese medicine composition of acute pancreatitis has and is:
Its selection of Chinese medicine composition of the present invention is natural, science compatibility, can quick pain relief pain, the abdominal distention that disappears, except inflammation, treatment pancreatitis is evident in efficacy, has no side effect, be on the market the pancreatitic common drug of other treatment far away less than.And can accomplish safety, without wound, for patient palliates the agonizing sufferings, other side effect of having avoided operative treatment or oral drug therapy to bring, through clinical verification, therapeutic effect is remarkable, greatly reduces mortality rate, improves cure rate.
The specific embodiment
Chinese medicine composition of the present invention is undergo and be used in the repeatedly extraordinary a kind of Chinese medicine for external application of practice effect of other patients with acute pancreatitis through inventor.
Following warp is described in further detail the present invention by concrete preferred embodiment, but the present invention is not limited in following embodiment.
The weight portion proportioning of 18 taste crude drug in Chinese medicine composition of the present invention is as follows, and the unit of following weight portion can be g, kg.
embodiment 1
Treating a Chinese medicine composition for acute pancreatitis, is to be made by the crude drug of following weight:
5 parts of Radix Et Rhizoma Rhei, 5 parts, Natrii Sulfas, 6 parts of Fructus Aurantiis, 9 parts of Cortex Magnoliae Officinalis, 5 parts of Radix Salviae Miltiorrhizaes, 5 parts of ligustrazine, 5 parts of breviscapines, 5 parts of Herba Artemisiae Scopariaes, 5 parts of Rhizoma Polygoni Cuspidati, 10 parts of Radix Bupleuri, 10 parts of Radix Gentianaes, 10 parts of the Rhizoma Pinelliaes, 5 parts of the Radix Paeoniae Albas, 2 parts of Radix Scutellariaes, 2 parts of Fructus Gardeniaes, 5 parts of Folium Ginkgos, 2 parts of Radix Et Caulis Acanthopanacis Senticosis, 2 parts of rutins.
Respectively above-mentioned 18 taste Chinese medicines are smashed to pieces, ground (200 order) powdering that sieves, then according to the weight portion proportioning mixing and stirring of above-mentioned each composition of raw materials.
Stir as powder, or add in addition 50-100ml Chinese liquor, be placed in sack, after heating water steams, hot compress, can be by the volatilization of ethanol in patient's abdominal part, similar medicated wine, can eliminate the seroperitoneum causing because of acute pancreatitis and promote pancreatitic improvement, soft tissue swelling and inflammation are all had to certain detumescence, antiinflammation.After band heat leaves, remove herbal fomentation bag, potion can be used week age.
Result shows: treatment group, in incidence rate and the matched group comparison of cure rate and complication, all has significant difference, and treatment group is better than matched group.Chinese medicine preparation external of the present invention has that prescription is rigorous, determined curative effect, is difficult for recurrence, avoids the advantages such as oral drugs toxic and side effects.
embodiment 2
Treating a Chinese medicine composition for acute pancreatitis, is to be made by the crude drug of following weight:
Radix Et Rhizoma Rhei 10g, Natrii Sulfas 10g, Fructus Aurantii 12g, Cortex Magnoliae Officinalis 15g, Radix Salviae Miltiorrhizae 10g, ligustrazine 10g, breviscapine 10g, Herba Artemisiae Scopariae 10g, Rhizoma Polygoni Cuspidati 10g, Radix Bupleuri 20g, Radix Gentianae 20g, Rhizoma Pinelliae 20g, Radix Paeoniae Alba 10g, Radix Scutellariae 6g, Fructus Gardeniae 6g, Folium Ginkgo 10g, Radix Et Caulis Acanthopanacis Senticosi 6g, rutin 6g.
Respectively above-mentioned 18 taste Chinese medicines are smashed to pieces, ground (200 order) powdering that sieves, then according to the weight portion proportioning mixing and stirring of above-mentioned each composition of raw materials.
Stir as powder, or add in addition 50-100ml Chinese liquor, be placed in sack, after heating water steams, hot compress, can be by the volatilization of ethanol in patient's abdominal part, similar medicated wine, can eliminate the seroperitoneum causing because of acute pancreatitis and promote pancreatitic improvement, soft tissue swelling and inflammation are all had to certain detumescence, antiinflammation.After band heat leaves, remove herbal fomentation bag, potion can be used week age.
Result shows: treatment group, in incidence rate and the matched group comparison of cure rate and complication, all has significant difference, and treatment group is better than matched group.Chinese medicine preparation external of the present invention has that prescription is rigorous, determined curative effect, is difficult for recurrence, avoids the advantages such as oral drugs toxic and side effects.
embodiment 3
Treating a Chinese medicine composition for acute pancreatitis, is to be made by the crude drug of following weight:
Radix Et Rhizoma Rhei 8g, Natrii Sulfas 8g, Fructus Aurantii 9g, Cortex Magnoliae Officinalis 12g, Radix Salviae Miltiorrhizae 8g, ligustrazine 8g, breviscapine 6g, Herba Artemisiae Scopariae 6g, Rhizoma Polygoni Cuspidati 7g, Radix Bupleuri 15g, Radix Gentianae 15g, Rhizoma Pinelliae 15g, Radix Paeoniae Alba 8g, Radix Scutellariae 4g, Fructus Gardeniae 4g, Folium Ginkgo 8g, Radix Et Caulis Acanthopanacis Senticosi 4g, rutin 4g.
Respectively above-mentioned 18 taste Chinese medicines are smashed to pieces, ground (200 order) powdering that sieves, then according to the weight portion proportioning mixing and stirring of above-mentioned each composition of raw materials.
Stir as powder, or add in addition 50-100ml Chinese liquor, be placed in sack, after heating water steams, hot compress, can be by the volatilization of ethanol in patient's abdominal part, similar medicated wine, can eliminate the seroperitoneum causing because of acute pancreatitis and promote pancreatitic improvement, soft tissue swelling and inflammation are all had to certain detumescence, antiinflammation.After band heat leaves, remove herbal fomentation bag, potion can be used week age.
Result shows: treatment group, in incidence rate and the matched group comparison of cure rate and complication, all has significant difference, and treatment group is better than matched group.Chinese medicine preparation external of the present invention has that prescription is rigorous, determined curative effect, is difficult for recurrence, avoids the advantages such as oral drugs toxic and side effects.
effects applications experimental example
The external application of Chinese medicine bag that uses the inventor to make when method is left hospital 60 routine inpatients, be divided at random treatment group (n=31) and standard control group (n=29), (treatment group is used Chinese medicine composition external application bag of the present invention every day, and matched group is used conventional Chinese medicine).
Relatively the average stomachache of two groups of cases alleviate natural law, cure required natural law, case fatality rate and average Chinese medicine expense.
Result treatment group is on average suffered from abdominal pain and is alleviated natural law 2.1d, curative day 14.7d, case fatality rate 0 (0/3).
Standard control group is on average suffered from abdominal pain and is alleviated natural law 6.29d, on average uses natural law 33.4d, and case fatality rate 14.0% (4/29), is on average used 218 yuan of Chinese medicine expenses.
In average stomachache, alleviate natural law (t=7.90 for two groups, P < 0.001), use natural law (t=4.19, P < 0.001) and in medical expenses (t=2.90, P < 0.01), more all there is a remarkable significant difference;
Case fatality rate also has significant difference (x2=4.58, P < 0.05).On conventional therapy basis, continue to use external application of Chinese medicine bag of the present invention, can control in time or reduce complication, significantly shorten the course of disease and significantly reduce case fatality rate and medical expense.
Below in conjunction with concrete case, further illustrate effect of the present invention:
Case 1:
Patient male, 46 years old, because of stomachache companion vomiting after drinking 12 hours.Patient feels Abdeminal pain discomfort after the meal, occurs the epigastrium pain of taking back after 1 hour, and paroxysmal increases the weight of, and to lower back, is banded transmitting.Vomit 2 times, vomitus is food debris and yellow bile.Epigastrium and the tenderness of taking back, rebound tenderness, muscle tonus.Tentative diagnosis is acute pancreatitis.Through specialist, introduce, use Chinese medicine composition hot compress bag of the present invention, the sense of abdominal part distending pain reduces, and lump diminishes until finally disappear, reach the curative effect of recovery from illness, and the present invention uses safety, and effectively, simple and convenient, patient satisfaction is high.
Case 2:
Patient male, 32 years old, suffer from abdominal pain 5 days, increase the weight of 3 days.Before five days there is upper abdominal pain after drinking in patient, for persistence angor, companion's paroxysmal increases the weight of, and to back part radiation, accompanies frequent nausea and vomiting, vomitus is gastric content and bile, at village's clinic, give fluid infusion, infection, press down acid Supporting Therapy to the ill, the state of an illness slightly take a favorable turn, and after the greasy diet that advances for 3 days, the state of an illness increases the weight of again, stomachache can not be alleviated, spread gradually to full abdomen, abdominal distention is obvious, and nausea and vomiting increases the weight of, anus stops exhaust defecation, urine amount is few, companion's dysphoria, and skin is clammy, for asking further diagnosis and treatment, emergency is medical.Tentative diagnosis is acute pancreatitis.Through specialist, introduce, use Chinese medicine composition hot compress bag of the present invention, the sense of abdominal part distending pain reduces, and lump diminishes until finally disappear, reach the curative effect of recovery from illness, and the present invention uses safety, and effectively, simple and convenient, patient satisfaction is high.
The above, it is only preferred embodiment of the present invention, not the present invention is done to any pro forma restriction, therefore every, do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the modification above embodiment done according to technical spirit of the present invention, all still belong in the scope of technical solution of the present invention.
Claims (2)
1. a Chinese medicine composition for the treatment of acute pancreatitis, is characterized in that: this Chinese medicine composition is comprised of each raw material of following weight portion proportioning:
Radix Et Rhizoma Rhei 5-8 part, Natrii Sulfas 5-8 part, Fructus Aurantii 6-9 part, Cortex Magnoliae Officinalis 9-12 part, Radix Salviae Miltiorrhizae 5-8 part, ligustrazine 5-8 part, breviscapine 5-8 part, Herba Artemisiae Scopariae 5-8 part, Rhizoma Polygoni Cuspidati 5-8 part, Radix Bupleuri 10-15 part, Radix Gentianae 10-15 part, Rhizoma Pinelliae 10-15 part, Radix Paeoniae Alba 5-8 part, Radix Scutellariae 2-4 part, Fructus Gardeniae 2-4 part, Folium Ginkgo 5-8 part, Radix Et Caulis Acanthopanacis Senticosi 2-4 part, rutin 2-4 part;
Smash, grind to form above-mentioned raw materials component to pieces powdery respectively, then according to the weight portion proportioning mixing and stirring of above-mentioned each composition of raw materials, the Chinese medicine composition after mixing and stirring is made to outer charging, be placed in sack.
2. the Chinese medicine composition for the treatment of acute pancreatitis according to claim 1, is characterized in that: this Chinese medicine composition is comprised of each raw material of following weight portion proportioning:
5 parts of Radix Et Rhizoma Rhei, 5 parts, Natrii Sulfas, 6 parts of Fructus Aurantiis, 9 parts of Cortex Magnoliae Officinalis, 5 parts of Radix Salviae Miltiorrhizaes, 5 parts of ligustrazine, 5 parts of breviscapines, 5 parts of Herba Artemisiae Scopariaes, 5 parts of Rhizoma Polygoni Cuspidati, 10 parts of Radix Bupleuri, 10 parts of Radix Gentianaes, 10 parts of the Rhizoma Pinelliaes, 5 parts of the Radix Paeoniae Albas, 2 parts of Radix Scutellariaes, 2 parts of Fructus Gardeniaes, 5 parts of Folium Ginkgos, 2 parts of Radix Et Caulis Acanthopanacis Senticosis, 2 parts of rutins;
Smash, grind to form above-mentioned raw materials component to pieces powdery respectively, then according to the weight portion proportioning mixing and stirring of above-mentioned each composition of raw materials, the Chinese medicine composition after mixing and stirring is made to outer charging, be placed in sack.
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| CN103505650B (en) * | 2013-08-31 | 2015-04-15 | 宋景戈 | Traditional Chinese medicine composition for treating acute pancreatitis |
| CN104623090A (en) * | 2015-01-12 | 2015-05-20 | 白忠可 | Heat-clearing dampness-removing traditional Chinese medicine preparation for treating pancreatitis and preparation thereof |
| CN110833550B (en) * | 2018-08-15 | 2023-03-24 | 广西梧州制药（集团）股份有限公司 | Application of pyrazolopyrimidine derivative in treatment of liver injury caused by acute pancreatitis |
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| CN100589820C (en) * | 2007-04-09 | 2010-02-17 | 湖北中医学院 | Chinese medicine composition for treating endotoxemia and its preparation process |
| CN101670065B (en) * | 2009-09-23 | 2011-05-11 | 张莉 | Preparation method of traditional Chinese medicine for treating acute pancreatitis |
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