CN101461911A

CN101461911A - A traditional Chinese medicinal capsule for treating gout

Info

Publication number: CN101461911A
Application number: CNA2008101796662A
Authority: CN
Inventors: 马献山
Original assignee: Individual
Current assignee: Individual
Priority date: 2008-12-01
Filing date: 2008-12-01
Publication date: 2009-06-24
Anticipated expiration: 2028-12-01
Also published as: CN101461911B

Abstract

本发明涉及一种治疗痛风的中药内服胶囊，也称痛风康胶囊。目前有人搞中药组合物治疗痛风，以粉萆薢、黄柏、秦皮、土伏苓、泽泻、车前草、海桐皮、怀牛膝和制大黄为原料制得的活性成分提取物与药用辅料组成的医学上可接受的各种口服制剂。本发明目的提供了一种治疗痛风的中药内服胶囊。技术内容为土茯苓、生意仁、萆薢、泽泻、车前子、地龙、赤芍、鸡血藤、当归等22种中草药原料经过磨碎、过筛、消毒、浓缩、混合等工序制成胶囊。用途是该胶囊为纯中药制剂，无毒作用，服用方便，治愈率高，通过燥湿健脾，泄浊祛瘀，止痛，促进尿酸排泄，消除炎症、解除疼痛，改善血液及肾脏等并发症，达到标本兼治的目的。The present invention relates to a Chinese medicine capsule for treating gout, also known as Tongfengkang capsule. At present, some people are engaged in the treatment of gout with Chinese medicine compositions, which are various medically acceptable oral preparations composed of active ingredient extracts prepared from raw materials such as Radix Dioscoreae, Cortex Phellodendri, Cortex Qinpi, Radix Poriae, Rhizoma Alismatis, Herba Plantaginis, Cortex Pittosporum, Radix Achyranthis Bidentatae and Radix Rhei as raw materials and pharmaceutical excipients. The purpose of the present invention is to provide a Chinese medicine capsule for treating gout. The technical content is that 22 kinds of Chinese herbal medicine raw materials such as Radix Smilax, Semen Ophiopogonis, Radix Dioscoreae, Rhizoma Alismatis, Semen Plantaginis, Pheretima, Radix Paeoniae Rubra, Caulis Millettiae, and Radix Angelicae Sinensis are ground, sieved, disinfected, concentrated, mixed, etc. to make capsules. The purpose is that the capsule is a pure Chinese medicine preparation, has no toxic effect, is easy to take, has a high cure rate, and can achieve the purpose of treating both the symptoms and the root causes by drying dampness and strengthening the spleen, purging turbidity and removing blood stasis, relieving pain, promoting uric acid excretion, eliminating inflammation, relieving pain, and improving complications such as blood and kidneys.

Description

A kind of oral medicinal herb capsule for the treatment of gout

One, technical field

The present invention relates to a kind of oral medicinal herb capsule for the treatment of gout, belong to the Chinese patent medicine field of medicaments.

Two, background technology

Gout is a kind of ancient disease, it also is a kind of frequently-occurring disease in recent years, have closely related with the raising of people's living standard, according to relevant report statistics than before 15 years, the patient has increased 15-30 doubly, and goat all can be fallen ill at any age, and gout is not single disease, but a kind of syndrome is caused by a kind of purine metabolic disturbance in the body.Acute arthritis to show effect repeatedly merges the gout calculus clinically, and blood uric acid concentration increases, and joint deformity and nephropathy etc. is a feature.A lot of patients had such painful experience, slight illness is then taken medicine, disease is gently then stopped, and takes various medicines for a long time in order to cure the disease, and has a medicine from a slice medicine, have several medicines from a kind of medicine, the state of an illness does not thoroughly take a turn for the better as a result, and injures one's stomach, and forms to rely on, the accumulation of drug residue composition is serious, does not finally reach ideal therapeutic effect.Be organ function worse and worse.

In State Intellectual Property Office the patent application that name is called " a kind of Chinese medicine composition and preparation method for the treatment of gout " is disclosed on the net, application number: 200510023218.X, open (bulletin) number: CN1803177 open (bulletin) day: 2006.07.19.This Chinese medicine composition is to be the medically acceptable various oral formulations that the active component extract that makes of raw material and pharmaceutic adjuvant are formed with Rhizoma Dioscoreae Hypoglaucae, Cortex Phellodendri, Cortex Fraxini, Rhizoma Smilacis Glabrae, Rhizoma Alismatis, Herba Plantaginis, Cortex erythrinae, Radix Achyranthis Bidentatae and Radix et Rhizoma Rhei (processed), this Chinese medicine composition has heat-clearing and toxic substances removing, let out turbid collateral dredging, the subduing swelling and relieving pain effect is mainly used in treatment gouty arthritis and hyperuricemia.

Three, summary of the invention

The objective of the invention is to develop a kind of oral medicinal herb capsule for the treatment of gout, i.e. the gout recovering capsule.The present patent application people thinks in secular Chinese medicine clinical practice, the cause of disease of gout is outside intrusions such as wind, cold, wet, heat, endogenous cause of ill and positive QI-insufficiency, work and rest is improper, and body constitution is lost empty relevant, and main pathogenesis is the turbid passages through which vital energy circulates of being detained of damp expectorant, QI-blood circulation is unsmooth, disease can cause phlegm-turbidity and blood stasis arthralgia due to stagnation of blood resistance for a long time, and kidney qi is impaired, and performance has void to have real and based on excess syndrome.

Technical solution of the present invention is as follows:

A kind of oral medicinal herb capsule for the treatment of gout is characterized in that: the parts by weight active drug by following herbal raw material is formed.

Rhizoma Smilacis Glabrae 30-50 part Semen Coicis 30-50 Fen Rhizoma Dioscoreae Septemlobae 30-50 part

Rhizoma Alismatis 10-15 part Semen Plantaginis 20-30 part Pheretima 10-15 part

Radix Paeoniae Rubra 10-15 part Caulis Spatholobi 20-30 part Radix Angelicae Sinensis 10-15 part

Radix Clematidis 10-15 part Fructus Liquidambaris 10-15 part Flos Lonicerae 20-30 part

Herba Sarcandrae 20-30 divides Radix Gentianae Macrophyllae 10-15 part Cortex Phellodendri 10-15 part

Rhizoma Atractylodis 6-10 part Rhizoma Anemarrhenae 6-10 part Rhizoma Corydalis 10-15 part

Rhizoma Chuanxiong 10-15 part Radix Achyranthis Bidentatae 10-15 part Herba Lysimachiae 10-20 part

Radix Aconiti 6-10 part

Technical solution of the present invention also comprises:

Make described a kind of capsular manufacturing technique method of oral medicinal herb for the treatment of gout, it is characterized in that: in turn include the following steps: the said herbal medicine raw material of getting clean dry, cross 240 mesh sieves by above-mentioned deal proportioning respectively or get one of 20 parts deals after mixing earlier and be milled to fine powder; Behind the uniform mixing, ultraviolet and/or 〉=100 ℃ of high temperature under the sterilization back standby; After get 9/20ths deals the Chinese herbal medicine decocting that adds 5 times of amounts after mixing boiled 2 hours, emit decocting liquid, twice decocting liquid mixed and filtration, after discarding slag, filtrate is concentrated into sixth volume adding ethanol placement clarification and gets supernatant reconcentration sixth volume, after adding one of 20 parts of above-mentioned remaining Chinese herbal medicine deal uniform mixing again, be milled to fine powder through super-dry; By capsule can packing machine " 0 " number capsule of packing into, every capsules medicated powder 0.5 gram of packing into is whenever on inspection bottledly gone into 100 capsules and can be treated pin with above-mentioned medicated powder.

Advantage of the present invention and effect are as follows:

The present invention is owing to adopt the Therapeutic Method of differential diagnosis in tcm in conjunction with modern drug effect principle,, can access effective healing, and have no side effect so make the patient through clinical trial in the short period of time through 2-5 course of therapy, have drying damp and strengthening spleenly, let out turbid stasis-dispelling and pain-killing.Promote urate excretion, eliminate ailingly, remove pain, improve complication such as blood and kidney, complication due to gout and the gout is had obvious treatment prevention and health-care effect.Reach 98% through clinical case checking effective percentage.

Add up 2007 and adopt the present invention to treat patient with gout 103 examples, wherein male 85 examples, the woman: 18 examples, age 30-65 year, 47.5 years old mean age, one month time of falling ill was to 10 years.

Diagnostic criteria is seen the specificity urate crystal according to looking in American Rheumatism Association's standard U.S. Holmes standard and Japanese revised edition standard .1, the synovial bursa liquid; 2, tophus confirms to contain the crystallization of uric acid sodium through chemical method or PLM; 3, possess 6 persons in 12 of following clinical laboratory and the X line signs etc.; (1) once above acute arthritis is shown effect; (2), inflammation why the disease performance reach the peak in one day; (3), single arthritis outbreak; (4), ill skin is kermesinus; (5), first sole of the foot joint pain swelling; (6), the first toe toe joint is involved in one-sided outbreak; (7), midtarsal joints is involved in one-sided outbreak; (8), suspicious tophus is arranged; (9), hyperuricemia; (10), the X line shows joint asymmetry swelling; (11), the X line is taken the photograph sheet and is shown that cyst corrodes without matter under the sclerotin; (12), joint fluid microorganism culturing feminine gender during the paresthesia epilepsy of joint.

Therapeutic Method, each five for oral administration, three times on the one, double first, 15 days is a course of treatment, obeys and adds up curative effect 3 courses of treatment.

The result observes, and cures 99 examples, 3 examples that take a turn for the better, invalid 1 example, the 15-30 days pain of wherein taking medicine is mistake person's 43 examples slightly, and 30-45 days transference cure person 11 examples of taking medicine, the 45 days symptoms of taking medicine have the alleviator to change to take traditional Chinese medicine dialectical therapist 3 examples slightly, put different treatment 1 example, total effective rate 98% cures 96%.

Four, the specific embodiment (following will with claim medicine correspondence, might as well search.Method for making is the same, and is more specifically good)

Embodiments of the invention are described as follows, and it is as follows to get the raw material of Chinese medicine proportioning:

Chinese herbal medicine	1 group	2 groups	3 groups	4 groups	5 groups	6 groups	7 groups	8 groups	9 groups	10 groups
Chinese herbal medicine	1 group	2 groups	3 groups	4 groups	5 groups	6 groups	7 groups	8 groups	9 groups	10 groups	Rhizoma Smilacis Glabrae	30 parts	32 parts	35 parts	36 parts	37 parts	38 parts	39 parts	45 parts	48 parts	50 parts
Give birth to Semen Coicis	50 parts	48 parts	45 parts	45 parts	44 parts	44 parts	38 parts	34 parts	31 parts	30 parts	Rhizoma Smilacis Glabrae	30 parts	32 parts	35 parts	36 parts	37 parts	38 parts	39 parts	45 parts	48 parts	50 parts
Give birth to Semen Coicis	50 parts	48 parts	45 parts	45 parts	44 parts	44 parts	38 parts	34 parts	31 parts	30 parts	Rhizoma Dioscoreae Septemlobae	30 parts	33 parts	35 parts	35 parts	36 parts	38 parts	39 parts	40 parts	45 parts	50 parts
Rhizoma Alismatis	15 parts	14.5 part	14 parts	13.5 part	13 parts	12.5 part	12 parts	11.5 part	11 parts	10 parts	Rhizoma Dioscoreae Septemlobae	30 parts	33 parts	35 parts	35 parts	36 parts	38 parts	39 parts	40 parts	45 parts	50 parts
Rhizoma Alismatis	15 parts	14.5 part	14 parts	13.5 part	13 parts	12.5 part	12 parts	11.5 part	11 parts	10 parts	Semen Plantaginis	30 parts	29 parts	29 parts	28 parts	25 parts	25 parts	24 parts	23 parts	20 parts	20 parts
Pheretima	15 parts	14 parts	13 parts	12 parts	11 parts	10 parts	10 parts	13 parts	14 parts	15 parts	Semen Plantaginis	30 parts	29 parts	29 parts	28 parts	25 parts	25 parts	24 parts	23 parts	20 parts	20 parts
Pheretima	15 parts	14 parts	13 parts	12 parts	11 parts	10 parts	10 parts	13 parts	14 parts	15 parts	Radix Paeoniae Rubra	10 parts	11 parts	11.5 part	12 parts	13 parts	13 parts	14 parts	14 parts	14 parts	15 parts
Caulis Spatholobi	30 parts	29 parts	29 parts	28 parts	27 parts	26 parts	22 parts	23 parts	20 parts	20 parts	Radix Paeoniae Rubra	10 parts	11 parts	11.5 part	12 parts	13 parts	13 parts	14 parts	14 parts	14 parts	15 parts
Caulis Spatholobi	30 parts	29 parts	29 parts	28 parts	27 parts	26 parts	22 parts	23 parts	20 parts	20 parts	Radix Angelicae Sinensis	15 parts	14.5 part	14 parts	13.5 part	13 parts	12.5 part	12 parts	11 parts	11 parts	10 parts
Radix Clematidis	10 parts	11 parts	11.5 part	12 parts	12.5 part	13 parts	13.5 part	14 parts	14.5 part	15 parts	Radix Angelicae Sinensis	15 parts	14.5 part	14 parts	13.5 part	13 parts	12.5 part	12 parts	11 parts	11 parts	10 parts
Radix Clematidis	10 parts	11 parts	11.5 part	12 parts	12.5 part	13 parts	13.5 part	14 parts	14.5 part	15 parts	Fructus Liquidambaris	15 parts	14 parts	13 parts	13 parts	11 parts	10 parts	15 parts	13 parts	12 parts	10 parts
Flos Lonicerae	30 parts	29 parts	28 parts	27 parts	26 parts	25 parts	24 parts	23 parts	22 parts	20 parts	Fructus Liquidambaris	15 parts	14 parts	13 parts	13 parts	11 parts	10 parts	15 parts	13 parts	12 parts	10 parts
Flos Lonicerae	30 parts	29 parts	28 parts	27 parts	26 parts	25 parts	24 parts	23 parts	22 parts	20 parts	Herba Sarcandrae	20 parts	21 parts	22 parts	23 parts	24 parts	25 parts	26 parts	27 parts	28 parts	30 parts
Radix Gentianae Macrophyllae	15 parts	14.5 part	14.5 part	14 parts	13 parts	13 parts	12 parts	11.5 part	11 parts	10 parts	Herba Sarcandrae	20 parts	21 parts	22 parts	23 parts	24 parts	25 parts	26 parts	27 parts	28 parts	30 parts
Radix Gentianae Macrophyllae	15 parts	14.5 part	14.5 part	14 parts	13 parts	13 parts	12 parts	11.5 part	11 parts	10 parts	Cortex Phellodendri	10 parts	11 parts	11.5 part	12 parts	12.5 part	13 parts	13.5 part	14 parts	14.5 part	15 parts
Rhizoma Atractylodis	6 parts	7 parts	8 parts	9 parts	10 parts	10 parts	9 parts	8 parts	7 parts	6 parts	Cortex Phellodendri	10 parts	11 parts	11.5 part	12 parts	12.5 part	13 parts	13.5 part	14 parts	14.5 part	15 parts
Rhizoma Atractylodis	6 parts	7 parts	8 parts	9 parts	10 parts	10 parts	9 parts	8 parts	7 parts	6 parts	The Rhizoma Anemarrhenae	10 parts	9 parts	8 parts	7 parts	6 parts	6 parts	7 parts	8 parts	9 parts	10 parts
Rhizoma Corydalis	15 parts	13 parts	12 parts	10 parts	11 parts	10 parts	14 parts	11 parts	12 parts	10 parts	The Rhizoma Anemarrhenae	10 parts	9 parts	8 parts	7 parts	6 parts	6 parts	7 parts	8 parts	9 parts	10 parts
Rhizoma Corydalis	15 parts	13 parts	12 parts	10 parts	11 parts	10 parts	14 parts	11 parts	12 parts	10 parts	Rhizoma Chuanxiong	10 parts	11 parts	12 parts	13 parts	14 parts	15 parts	14 parts	13 parts	12 parts	10 parts
Radix Achyranthis Bidentatae	15 parts	14 parts	13 parts	12 parts	11 parts	10 parts	12 parts	13 parts	14 parts	15 parts	Rhizoma Chuanxiong	10 parts	11 parts	12 parts	13 parts	14 parts	15 parts	14 parts	13 parts	12 parts	10 parts
Radix Achyranthis Bidentatae	15 parts	14 parts	13 parts	12 parts	11 parts	10 parts	12 parts	13 parts	14 parts	15 parts	Herba Lysimachiae	10 parts	10.5 part	10 parts	13 parts	17 parts	18 parts	18 parts	19 parts	20 parts	20 parts
Radix Aconiti	6 parts	7 parts	8 parts	9 parts	10 parts	10 parts	9 parts	8 parts	7 parts	6 parts	Herba Lysimachiae	10 parts	10.5 part	10 parts	13 parts	17 parts	18 parts	18 parts	19 parts	20 parts	20 parts
Radix Aconiti	6 parts	7 parts	8 parts	9 parts	10 parts	10 parts	9 parts	8 parts	7 parts	6 parts	Amount to	397 parts	397 parts	397 parts	397 parts	397 parts	397 parts	397 parts	397 parts	397 parts	397 parts

Method for making is as follows:

The pure medical material of getting above-mentioned ten groups of consumptions respectively with the kilogram be unit as umber, promptly 1 part equals 1 kilogram.The approximately nearly 20kg of said herbal medicine raw material 1/20th amount meter that gets clean dry earlier wears into fine powder, crosses 240 mesh sieves, behind the uniform mixing, ultraviolet and/or 〉=100 ℃ of high temperature under the sterilization back standby; At high temperature the sterilization back is standby, and also available certainly disinfection by ultraviolet light or both all use the back standby.Then 9/20ths medical material, metering is approximately 377Kg, boiled 2 hours with the decocting that adds 5 times of amounts after the standby fine powder material in preceding sterilization back mixes, decocted 1 hour for the second time, behind the waste, collecting decoction, be concentrated into the sixth volume and be rare silk fabric paste, add ethanol 200Kg precipitation then, place clarification, get supernatant and be filtered to clear and bright, the about 50Kg of reconcentration extractum (is exactly that 1/20th amount is worn into fine powder with above-mentioned medicated powder, cross the 20kg of 240 mesh sieves) dry after mixing the about 65Kg of finished product, per 0.5 gram fine powder Chinese medicine of weighing is loaded on " 0 " number capsule, whenever bottledly goes into 100 capsules and gets final product through checking.

Drug effect principle of the present invention is:

Rhizoma Smilacis Glabrae detoxifcation dehumidifying, easing joint movement; Give birth to the Semen Coicis promoting diuresis to eliminate damp pathogen, spleen invigorating eliminating impediment clearing away heat and discharging pus; The Rhizoma Dioscoreae Septemlobae dampness removing is dispelled turbid, expelling wind and removing dampness; Three medicines share detoxifcation dehumidifying Synergistic, the effect of coordinating mutually played.The Radix Gentianae Macrophyllae wind-damp dispelling, stopping numbness pain, reducing the asthenic fever; Cortex Phellodendri, Rhizoma Atractylodis, the Rhizoma Anemarrhenae, Radix Achyranthis Bidentatae heat clearing and damp drying, nourishing YIN to lower pathogenic fire; Rhizoma Alismatis, Semen Plantaginis, Herba Lysimachiae, inducing diuresis for treating stranguria syndrome purges heat, and removes arthralgia chiefly caused by damp pathogen and alkalized urine is arranged, and promotes the urate calculus dissolving; Radix Clematidis, Fructus Liquidambaris dispelling wind and removing obstruction in the collateral diuretic; Radix Clematidis has hard masses softening and resolving, and the expansion ureter is that the defeated urine wriggling rhythm and pace of moving things strengthens and alkalized urine, has increased Rhizoma Alismatis again, Semen Plantaginis, the diuresis of Jin Qiancao; Pheretima heat clearing away collateral dredging tonneau urine, reducing swelling and alleviating pain; Radix Paeoniae Rubra, Caulis Spatholobi, Radix Angelicae Sinensis blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain; Rhizoma Corydalis, the pain relieving of Rhizoma Chuanxiong blood-activating and qi-promoting; The Radix Aconiti expelling wind and removing dampness, dispersing cold for relieving pain; Flos Lonicerae, Herba Sarcandrae, has the heat-clearing and toxic substances removing wind-expelling pain-stopping, dispelling wind and heat pathogens, Herba Sarcandrae have the effect of the sclerotin healing of promotion, human body immunity improving power, destructive joint there is repair, Flos Lonicerae simultaneously, Herba Sarcandrae claims natural antibiotics again, and urate is caused that urinary tract infection plays treatment and preventive effect.

The invention reside in ingenious use proportioning ladies and gentlemen medicine, play treating both the principal and secondary aspects of a disease through the clinical trial proof and have the obvious treatment functions of prevention and health care.

Claims

1, a kind of oral medicinal herb capsule for the treatment of gout, it is characterized in that: the parts by weight active drug by following herbal raw material is formed.

Rhizoma Alismatis 10-15 part Semen Plantaginis 20-30 part Pheretima 10-15 part

Radix Aconiti 6-10 part.

2 make the described a kind of capsular manufacturing technique method of oral medicinal herb for the treatment of gout of claim 1, it is characterized in that: following steps successively: the said herbal medicine raw material of getting clean dry, cross 240 mesh sieves by above-mentioned deal proportioning respectively or get one of 20 parts deals after mixing earlier and be milled to fine powder; Behind the uniform mixing, ultraviolet and/or 〉=100 ℃ of high temperature under the sterilization back standby; After get 9/20ths deals the standby fine powder material in Chinese herbal medicine and the preceding sterilization back decocting that adds 5 times of amounts after mixing boiled 2 hours, emit decocting liquid, twice decocting liquid mixed and filtration, after discarding slag, filtrate is concentrated into sixth volume adding ethanol placement clarification and gets supernatant reconcentration sixth volume, after adding one of ten parts of above-mentioned remaining Chinese herbal medicine deal uniform mixing again, be milled to fine powder through super-dry; By capsule can packing machine " 0 " number capsule of packing into, every capsules medicated powder 0.5 gram of packing into is whenever on inspection bottledly gone into 100 capsules and can be treated pin with above-mentioned medicated powder.