CN101972333A - Medicament for eliminating turbid urines and activating blood stasis - Google Patents
Medicament for eliminating turbid urines and activating blood stasis Download PDFInfo
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- CN101972333A CN101972333A CN201010506059.XA CN201010506059A CN101972333A CN 101972333 A CN101972333 A CN 101972333A CN 201010506059 A CN201010506059 A CN 201010506059A CN 101972333 A CN101972333 A CN 101972333A
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Abstract
The invention discloses a medicament for eliminating turbid urines and activating blood stasis, which comprises the following compositions in part by weight: 10 to 20 parts of fried atraotydin, 10 to 20 parts of fried amur corktree bark, 5 to 10 parts of prepared rhubarbs, 5 to 10 parts of prepared tablets, 10 to 20 parts of giant knot weeds, and 15 to 20 parts of suberect spatholobus stems. In the invention, the fried atraotydin and the fried amur corktree bark have the effects of clearing heat and promoting diuresis; the prepared rhubarbs and the prepared tablets have the effects of clearing heat and warming kidney, and purgating fu-organs and eliminating turbid urines; and the giant knot weeds and the suberect spatholobus stems have the effects of activating blood stasis and activating collaterals; therefore, the c of the invention has the effects of promoting diuresis and eliminating turbid urines, reducing blood uric acid, clearing heat and activating collaterals, treating urarthritis, and warming kidney and eliminating turbid urines, and treating chronic renal insufficiency, is less in side effect and definite in curative effect. The clinical observation results (setting control groups) show that the invention can improve the clinical symptoms obviously. The symptom scores of a treatment group before and after integration have an obvious difference P (0.01). The medicine of the invention has the effects of reducing uric acid and inflammatory markers as well as triglycerides and improving renal function. The total effective rate of the medicine is 87 percent, which is better than that of the control group (the total effective rate is 60 percent, P: 0.05). The medicine has no obvious side effect.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, be specifically related to a kind of turbid logical stasis of blood agent of letting out.
Background technology
Gout (Gout) is the caused one group of disease of purine metabolic disturbance in the body, clinical characters is that acute single arthritis, the uric acid sodium salt of hyperuricemia, outbreak repeatedly forms tophus deposition, tophus chronic arthritis, also involve kidney easily and cause gouty nephropathy, renal insufficiency, and both reciprocal causations, touching difficulty are more.Relevant disease also comprises hyperuricemia, gouty arthritis, gouty nephropathy and chronic renal insufficiency etc.This disease significantly improves at the sickness rate of China, and according to statistics, this sick sickness rate is near foreign level in China big and medium-sized cities.Still can not effect a radical cure primary disease at present, the chemicals determined curative effect, onset is rapid, but has serious toxic and side effects, especially to the patient of old age and hepatic and kidney function obstacle.Toxic reaction is little, the advantage for the treatment of both the principal and secondary aspects of a disease and Chinese medicine has, and can improve symptom in acute stage, can regulate function in chronic phase and catabasis again, makes body negative and positive of qi and blood balance, thereby reduces recurrence.But determined curative effect, ripe Chinese medicine with strong points is rarely seen.
At present, the medicine of doctor trained in Western medicine uric acid reducing mainly contains two classes, and the one, the medicine of promotion urate excretion, for example: benzbromarone, probenecid and sulphinpyrazone); Another is to suppress uricopoiesis, for example: allopurinol.Control the colchicine that has of acute stage inflammatory reaction.The Western medicine uricosuric when the above impaired renal function of moderate or uric acid discharge and too much can cause uric acid calculus, increase the weight of renal damage; Suppress uric acid medicine allopurinol serious exfoliative dermatitis, hepatorenal damage can take place, but threat to life very; Control acute stage inflammatory reaction medicine colchicine has side effect such as intensive diarrhoea, vomiting, bone marrow depression, hepatic injury.The medicine of Chinese medicine uric acid reducing mainly contains Baihu Jia Guizhi Tang, Simiao San, Tetrandra and Astragalus Decoction, LIUWEI DIHUANG WAN, TAOHONG SIWU TANG and guarantor unit soup etc.Chinese medicine only biases toward gout mechanism in a certain respect, when especially old gout merges renal insufficiency, is difficult to take into account, and traditional Chinese medical science uncertain therapeutic efficacy is cut.
Summary of the invention
Goal of the invention: at the deficiencies in the prior art, the purpose of this invention is to provide a kind of turbid logical stasis of blood agent of letting out, to realize effective uric acid reducing, inflammation index, triglyceride and to improve the renal function effect.
Technical scheme: in order to realize the foregoing invention purpose, the technical solution used in the present invention is as follows:
A kind ofly let out turbid logical stasis of blood agent, comprise each component of following parts by weight: 10 ~ 20 parts of Rhizoma Atractylodis (parched), 10 ~ 20 parts of Cortex Phellodendri (parched), 5 ~ 10 parts of Radix et Rhizoma Rhei (processed), 5 ~ 10 parts of Radix Aconiti Lateralis Preparata, 10 ~ 20 parts of Rhizoma Polygoni Cuspidati, 15 ~ 20 parts of Caulis Spatholobis.
Of the present invention to let out turbid logical stasis of blood agent be brown irregular granule, bitter in the mouth; Employing aluminium plastic bag packing, every packed 12g; Let out turbid damp clearly, the promoting the circulation of blood blood stasis dispelling.Be used for hyperuricemia, hyperlipemia, blood high viscosity syndrome, slight renal insufficiency etc.
A kind of preparation method of letting out turbid logical stasis of blood agent may further comprise the steps:
(1) get Cortex Phellodendri (parched) and be ground into coarse powder, press percolation with 65% alcohol dipping 24h after percolation, control per minute flow 2ml, to the percolate color light till (collecting 5000ml approximately), it is standby to make the Cortex Phellodendri (parched) extracting solution;
(2) Radix Aconiti Lateralis Preparata is crushed to the particle of Semen phaseoli radiati size, adds 80% ethanol 800ml, dipping spends the night, reflux, extract, 2h, and the leaching medicinal liquid merges with the Cortex Phellodendri (parched) extracting solution of step (1), and ethanol reclaims, and it is standby to make alcohol extract;
(3) Radix Aconiti Lateralis Preparata medicinal residues and residue medical material were added water retting after 2 hours, decoct 2 times, back 1.5h leaching medicinal liquid boils at every turn, centrifugal or staticly settle, get supernatant and be evaporated in right amount, merge with the alcohol extract of step (2), be evaporated to the thick paste shape, add dextrin and mix drying under reduced pressure, pulverize, cross sieve No. 3, add an amount of alcohol granulation, drying, granulate, promptly, wherein, the contained dextrin amount of finished product is≤63%.
Let out turbid logical stasis of blood agent and be used for the treatment of application in hyperuricemia, gouty arthritis, gouty nephropathy and the chronic renal insufficiency medicine in preparation.
Of the present inventionly let out turbid logical stasis of blood agent: damp and hot to remove in the prescription with two wonderful (Rhizoma Atractylodis, Cortex Phellodendri) heat clearing and damp drying, right damp and hot its at spleen, drying damp and strengthening spleen with Rhizoma Atractylodis, close the sedimentation of Cortex Phellodendri bitter cold again, clear respectful damp and hot, separate damp and hot sore, the two medicines clean source of clear stream that is harmonious, giving consideration to both the incidental and fundamental is monarch drug altogether.It is turbid to cooperate the Radix Et Rhizoma Rhei heat clearing away to let out, and the logical stasis of blood is invigorated blood circulation, and the Radix Aconiti Lateralis Preparata the kidney warming is let out and turbidly made that two the moon go out turbid damp from front and back.Play the effect of letting out the turbid logical stasis of blood altogether.The eliminating damp-heat of Rhizoma Polygoni Cuspidati tool, the analgesic therapy of invigorating blood circulation, blood circulation promoting and blood stasis dispelling, cooling blood for hemostasis, dispelling wind and removing obstruction in the collateral, heat-clearing and toxic substances removing, let out damp and hot, removing summer-heat, turbid, the relieving constipation by purgation of expectorantization clearly.Caulis Spatholobi has promoting the circulation of blood enriches blood, the relaxing muscles and tendons and activating QI and blood in the collateral function.Wherein: Cortex Phellodendri: chemical constituent has alkaloids such as berberine, magnoflorine, phellodendrine, candicine, Dauricine; Other has obacunone, obakulactone, dictamnolide, obacunonic acid, lumicaeruleic acid, T-dehydrogenation stigmasterol, cupreol, campesterol, limonin.Pharmacological action has anti-inflammation detumescence, blood pressure lowering, anti-hepatitis, antiulcer, inhibition central nervous system etc.
Rhizoma Atractylodis: pharmacology teaching and research room of Medical College, produce the acetic acid ethyl ester extract of atractylodes japonica with Jilin, cause mice auricular concha inflammatory model by dimethylbenzene and Oleum Tiglii, chondrus ocellatus Holmes and Ovum Gallus domesticus album cause the rat paw edema model and carry out pharmacological research, the result shows, the acetic acid ethyl ester extract of atractylodes japonica has the good restraining effect to above-mentioned auricular concha inflammation and foot swelling, compares there was no significant difference (P＜0.01) with indometacin.But the antiinflammatory immunity function of atractylodes japonica may be the secretion of its adrenal cortex reinforcing hormone, suppress the synthetic of PGS and discharge, inflammatory mediator there is the facedown effect, thereby reduction capillary permeability, atractylodes japonica also can increase the content of SOD in serum in addition, thus the cell that the inhibition oxygen-derived free radicals causes and the inflammation damnification of tissue.
Radix Et Rhizoma Rhei: Radix Et Rhizoma Rhei has anti-infectious function, and is all inhibited to multiple Gram-positive and negative bacterium.Radix Et Rhizoma Rhei have immunologic function dual regulation, remove oxygen-derived free radicals effect, bacteria-inhibiting anti-inflammation function, diuresis, improve insulin resistant.Radix Et Rhizoma Rhei has the carbamide of reduction, creatinine effect.
Radix Aconiti Lateralis Preparata: the Radix Aconiti Lateralis Preparata decoct is effects such as obvious antiinflammation blood sugar reducing function to formaldehyde and the swollen joint of rat.Radix Aconiti Lateralis Preparata has the infiltration of the blood capillary of inhibition, suppresses granuloma and forms anti-inflammatory and antalgic detumescence effect.
Rhizoma Polygoni Cuspidati: contain a kind of material that is emodin in the Rhizoma Polygoni Cuspidati, it has activated mononuclear emiocytosis tumor necrosis factor TNF-alpha and interleukin 1,6,8(IL-1, IL-6, IL-8), and can suppress the secretion of the above-mentioned factor of endotaxin induction, it has stronger inhibitory action to xanthine oxidase, thereby can reduce the synthetic of uric acid.Rhizoma Polygoni Cuspidati also has anticoagulant, antithrombotic, microcirculation improvement, antiinflammatory shock, effect for reducing blood fat.
Caulis Spatholobi: the water extract-alcohol precipitation preparation can increase the laboratory animal femoral artery blood flow, reduces vascular resistance, and platelet aggregation is had obvious inhibitory action; Water extract and tincture have the obvious anti-inflammatory and anti effect, and immune system is had dual regulation.
Beneficial effect: turbid logical stasis of blood agent, Rhizoma Atractylodis (parched), Cortex Phellodendri (parched), the clearing away heat-damp and promoting diuresis let out of the present invention; Radix et Rhizoma Rhei (processed), Radix Aconiti Lateralis Preparata, heat clearing away the kidney warming, purging FU-organs are let out turbid; Rhizoma Polygoni Cuspidati, Caulis Spatholobi, disperse blood stasis and dredge collateral; All medicines close it, but that dampness removing is let out is turbid, reduce blood uric acid, but heat clearing away collateral dredging again, the treatment gouty arthritis; And but the kidney warming purging FU-organs is let out turbid treatment chronic renal insufficiency.Side effect is little, determined curative effect.Effect: clinical observation (is set up matched group, can obviously be improved clinical symptoms.Significant difference P＜0.01 is arranged before and after the treatment group symptom integral.Have uric acid reducing, inflammation index, triglyceride and improve the renal function effect.Total effective rate 87% is better than matched group total effective rate 60%(P＜0.05).Do not see apparent side effect.
The specific embodiment
The present invention will be further explained below in conjunction with specific embodiment.
Embodiment 1
A kind ofly let out turbid logical stasis of blood agent, 10 parts of Rhizoma Atractylodis (parched), 10 parts of Cortex Phellodendri (parched), 5 parts of Radix et Rhizoma Rhei (processed), 6 parts of Radix Aconiti Lateralis Preparata, 10 parts of Rhizoma Polygoni Cuspidati, 20 parts of Caulis Spatholobis.
Get Cortex Phellodendri (parched) and be ground into coarse powder, press percolation with 65% alcohol dipping 24h after percolation, control per minute flow 2ml, to the percolate color light till, collect 5000ml approximately, standby; Radix Aconiti Lateralis Preparata is crushed to the particle of Semen phaseoli radiati size, adds 80% ethanol 800ml, dipping spends the night, reflux, extract, 2h, and the leaching medicinal liquid merges with the Cortex Phellodendri (parched) extracting solution, reclaims ethanol, and is standby; Its slag adds water retting with the residue medical material and decocts 2 times after 2 hours, the back 1.5h leaching medicinal liquid that at every turn boils, centrifugal (or leaving standstill) precipitation, get supernatant and be evaporated in right amount, be about 2000mL, merge with alcohol extract, be evaporated to the thick paste shape, add an amount of dextrin and mix drying under reduced pressure, pulverize, cross sieve No. 3, add an amount of alcohol granulation, consumption of ethanol should be able to guarantee agglomerating with extract powder “ Pinch, and flicking unclamps " get final product drying; granulate, promptly.The contained dextrin amount of finished product is≤63%.
Case: patient Liu, man, 74 years old, government functionary, first visit on the 12nd in 01 month in 2006.Occurred the left side foot first metatarsophalangeal joints congestion and swelling pain before 10 years behind the feed seafood, walking can not.Give colchicine treatment back symptom and take a turn for the better (but diarrhoea is violent), but joint still has slight congestion and swelling pain, increases the weight of during especially with activity.After this, whenever in drinking or the recurrence of tired back, begin annual outbreak 1～2 time, recurrent number increases in recent years, and recently because of recurrence once more after drinking, coming, I go to a doctor at institute.Disease is seen: left side foot the 1st metatarsophalangeal joints congestion and swelling pain, that touches is scorching hot, has difficulty in going to sleep xerostomia, yellow urine, red tongue, yellow and greasy fur, slippery and rapid pulse.The blood uric acid inspection is 489 umol/L, is diagnosed as gouty arthritis, and card belongs to retention of damp-heat in the interior, numbness resistance meridians.Control with clearing heat and expelling damp promoting blood circulation, dredging meridian and relieving pain.Take above-mentioned preparation, and advise its fasting wine meat, pluck etc. in case give birth in damp and hot, blood uric acid is reduced to 394.4umol/L after 14 days, and the affected part red and swollen heat pain disappears, and activity freely; Continue and obey 10 doses of tops, follow up a case by regular visits to and do not recur October.
Embodiment 2
A kind ofly let out turbid logical stasis of blood agent, prescription is as follows: 20 parts of Rhizoma Atractylodis (parched), 20 parts of Cortex Phellodendri (parched), 10 parts of Radix et Rhizoma Rhei (processed), 10 parts of Radix Aconiti Lateralis Preparata, 10 parts of Rhizoma Polygoni Cuspidati, 15 parts of Caulis Spatholobis.Preparation method is with embodiment 1.
Case: patient Wang, the woman, 54 years old, retirement, first visit in 2004 is a gouty nephropathy, never cures.Before 2010, came to check treatment.Disease is seen: slight edema and moderate hypertension appear in the bilateral lumbago.Urine is acid, nocturia, polyuria occur, the urine relative density is on the low side.Control with clearing heat and expelling damp promoting blood circulation, dredging meridian and relieving pain.Take above-mentioned preparation, and advise its fasting wine meat, pluck etc. in case give birth in damp and hot, blood uric acid is reduced to normal range behind the first quarter moon, and pain obviously alleviates, and activity freely; Continue and obey 10 doses of tops, do not follow up a case by regular visits to recurrence.
Embodiment 3
A kind ofly let out turbid logical stasis of blood agent, prescription is as follows: 15 parts of Rhizoma Atractylodis (parched), 15 parts of Cortex Phellodendri (parched), 7 parts of Radix et Rhizoma Rhei (processed), 5 parts of Radix Aconiti Lateralis Preparata, 20 parts of Rhizoma Polygoni Cuspidati, 18 parts of Caulis Spatholobis.Preparation method is with embodiment 1.
Case: patient Lee, the man, 65 years old, the retired worker, first visit in 2007 is a chronic renal insufficiency, never cures.Before 2010, came to check treatment.Disease is seen: polyuria, frequent urination at night, acidosis, anemia and symptom such as weak.Control with clearing heat and expelling damp promoting blood circulation, dredging meridian and relieving pain.Take above-mentioned preparation, and advise its fasting wine meat, pluck etc. in case give birth in damp and hot, after 20 days, the state of an illness obviously alleviates, and the clothes that continue were gone up prescription one month, basic rehabilitation, and all within normal range, activity is freely for leading indicator.
Claims (6)
1. let out turbid logical stasis of blood agent for one kind, it is characterized in that, comprise each component of following parts by weight: 10 ~ 20 parts of Rhizoma Atractylodis (parched), 10 ~ 20 parts of Cortex Phellodendri (parched), 5 ~ 10 parts of Radix et Rhizoma Rhei (processed), 5 ~ 10 parts of Radix Aconiti Lateralis Preparata, 10 ~ 20 parts of Rhizoma Polygoni Cuspidati, 15 ~ 20 parts of Caulis Spatholobis.
2. one kind prepares the described method of letting out turbid logical stasis of blood agent of claim 1, it is characterized in that, may further comprise the steps:
(1) get Cortex Phellodendri (parched) and be ground into coarse powder, press percolation with 65% alcohol dipping 24h after percolation, control per minute flow 2ml, to the percolate color light till, it is standby to make the Cortex Phellodendri (parched) extracting solution;
(2) Radix Aconiti Lateralis Preparata is crushed to the particle of Semen phaseoli radiati size, adds 80% ethanol 800ml, dipping spends the night, reflux, extract, 2h, and the leaching medicinal liquid merges with the Cortex Phellodendri (parched) extracting solution of step (1), and ethanol reclaims, and it is standby to make alcohol extract;
(3) Radix Aconiti Lateralis Preparata medicinal residues and residue medical material were added water retting after 2 hours, decoct 2 times, back 1.5h leaching medicinal liquid boils at every turn, centrifugal or staticly settle, get supernatant and be evaporated in right amount, merge with the alcohol extract of step (2), be evaporated to the thick paste shape, add dextrin and mix drying under reduced pressure, pulverize, cross sieve No. 3, add an amount of alcohol granulation, drying, granulate, promptly, wherein, the contained dextrin amount of finished product is≤63%.
3. claim 1 is described lets out turbid logical stasis of blood agent and is used for the treatment of application in the antihyperuricemic disease drug in preparation.
4. claim 1 is described lets out turbid logical stasis of blood agent and is used for the treatment of application in the gouty arthritis medicine in preparation.
5. claim 1 is described lets out turbid logical stasis of blood agent and is used for the treatment of application in the gouty nephropathy medicine in preparation.
6. claim 1 is described lets out turbid logical stasis of blood agent and is used for the treatment of application in the chronic renal insufficiency medicine in preparation.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102139004A (en) * | 2011-03-31 | 2011-08-03 | 朱婉华 | Plaster for treating gout disease and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101461911A (en) * | 2008-12-01 | 2009-06-24 | 马献山 | Chinese medicine oral capsule for treating gout |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101461911A (en) * | 2008-12-01 | 2009-06-24 | 马献山 | Chinese medicine oral capsule for treating gout |
Non-Patent Citations (1)
| Title |
|---|
| 《中国中医急症》 20051231 张琳等 痛风病的中医药治疗近况 1220-1221 1-5 第14卷, 第12期 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102139004A (en) * | 2011-03-31 | 2011-08-03 | 朱婉华 | Plaster for treating gout disease and application thereof |
| CN102139004B (en) * | 2011-03-31 | 2012-06-13 | 朱婉华 | Plaster for treating gout disease and application thereof |
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| CN101972333B (en) | 2012-06-27 |
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