CN100333755C - Nephrosis treating Chinese medicine boneyed bolus and its prepn process - Google Patents

Abstract

The present invention relates to a pure traditional Chinese medicine honey pill for treating kidney diseases and preparation technique thereof, which provides a medicine preparation for treating kidney diseases and a preparation technique thereof. The medicine preparation is prepared from fifteen traditional Chinese medicines, such as milkvetch root, dodder seed, black alum, etc. The preparation method of the pure traditional Chinese medicine honey pill for treating kidney diseases comprises the four steps: mixing medicine powder; decocting the medicine powder into thick paste; stirring the thick paste into pills; sterilizing and subpackaging the pills. The pure traditional Chinese medicine honey pill has the advantages of scientific formula, simple and convenient preparation process and low cost, and has the functions of tonifying the kidney, promoting urination, supplying qi, securing the exterior, nourishing the liver, moistening the lung, warning the spleen, promoting digestion, benefiting blood, quieting heart spirit, eliminating blood stasis and regenerating new blood. Besides the pure traditional Chinese medicine honey pill has obvious treatment effects on protein urine, bloody urine, edema, etc. caused by acute and chronic nephritis, diabetes kidney diseases, hypertension kidney diseases, henoch-schonlein purpura nephritis and nephrotic syndromes.

Description

Treatment pure Chinese medicine pill of nephropathy and preparation technology thereof

Affiliated technical field

The present invention treats the pure Chinese medicine pill of nephropathy and preparation technology belongs to medicine and the preparation technology thereof who treats urinary disorders, relates in particular to medicine and preparation technology thereof with Chinese prescription treatment nephropathy.

Background technology

Nephropathy is a commonly encountered diseases, acute nephritis is arranged, chronic nephritis, diabetic nephropathy, hypertensive nephropathy, the nephrotic syndrome and henoch Schonlein purpura nephritis etc., nephropathy can occur in all ages and classes, with green grass or young crops, middle age at most, stadium is long, a lot of variation, routine urianlysis is with albuminuria, cast, erythrocyte is main performance, often be mixed with edema, hypertension, diabetes, hyperlipemia, diseases such as vascular purpura are damaged with renal function in various degree, anxious, chronic nephritis all has substantial connection with the multiple pathogenic bacteria of infection especially Hemolytic streptococcus, also have and Diplococcus pneumoniae, staphylococcus, the germ nephropathy of multiclass such as gonococcus, henoch Schonlein purpura nephritis is caused by vascular purpura, the nephrotic syndrome contain more blood fat too high and urine in fatty corpusculum be feature, all can cause renal function slowly to go down, the nephrotic from asymptomatic to tangible hematuria, edema, hypertension, even uremia, state of an illness length is also different, worsen the rapid person of development and can enter Bing Du Zheng Bands section in the several months and death in onset, state of an illness the lighter can fully recover voluntarily, slow person is sustainable more than 20 years, with the passing of time involve liver, spleen, stomach, the impaired hypofunction that causes of the many organ pipes of lung, the body constitution decline, even Qi and blood deficiency, deficiency of kidney yin, stagnant blood stream knot, the five internal organs decline and dry up, be the lower limb weakness, a little less than the waist knee joint fistula, the phlegm retention of quenching one's thirst, weak breathe heavily more, multiple weakness symptom such as cardiopalmus coma, the medicine of treatment nephropathy is with sterilization at present, antibacterial medicines is main, yet the generation of nephropathy and development are closely related with body immunity again, the recovery of nephropathy is also closely related with the recovery of many organ pipes again, curative effect single medicine treatment nephropathy is often attended to one thing and lose sight of another, curative effect is relatively poor, and exploitation possesses sterilization simultaneously, antibacterial, improve immunity and treat many organ pipes simultaneously and mix the active drug of the treatment nephropathy of a disease function and have vast market prospect.

Summary of the invention

The objective of the invention is: provide scientific formulation, medication oligospermia, the significant pure Chinese medicinal preparation of complementary action to the nephrotic, reach kidney tonifying diuresis, invigorating QI to consolidate the body surface resistance, possess simultaneously sterilization, antibacterial, improve immunity function and liver, spleen, stomach, the many organ pipes of lung had nourishing effects, can effectively treat multiple nephropathy such as acute and chronic nephritis, diabetic nephropathy, hypertensive nephropathy, the nephrotic syndrome and henoch Schonlein purpura nephritis.

To achieve these goals, the technical solution used in the present invention is: the pure Chinese medicine pill of treatment nephropathy is according to nephropathy and mix the main etiology and pathogenesis of morbidity disease, with sterilization, antibacterial and the nourishing liver, spleen, stomach, it is principle of treatment that lung improves body immunity, the raw material total amount is 1180 grams in the prescription, by the Radix Astragali 50 grams, Semen Cuscutae 75 grams, Fructus Lycii 50 grams, Herba Taxilli 60 grams, Fructus Psoraleae 60 grams, Caulis Spatholobi 75 grams, Caulis Sargentodoxae 60 grams, Squama Manis 40 grams, Cornu Cervi 50 grams, Radix Codonopsis 50 grams, Herba Taraxaci 50 grams, Fructus Jujubae 30 grams, Alumen preparata 100 grams, Cinnabaris 30 grams and Mel 400 grams are formed, and also available Adeps Sus domestica substitutes Mel and makes oily ball.The production method of the pure Chinese medicine pill of preparation treatment nephropathy is divided into mixes the powder process medicine, decocting to thick ointment, puddle pill sterilization packing four road technologies, get Cinnabaris earlier, Alumen preparata porphyrize is respectively crossed 80 mesh sieves and is become fine powder, get the Radix Astragali again, Semen Cuscutae, Fructus Lycii, Herba Taxilli, Fructus Psoraleae, Caulis Spatholobi, Caulis Sargentodoxae, Squama Manis, Cornu Cervi nine flavor medicines mixing were pulverized 80 mesh sieves and were become fine powder, again with Cinnabaris, Alumen preparata fine powder mixing or fine powder medicine are standby, to tail over medicinal residues and Fructus Jujubae again, Radix Codonopsis, Herba Taraxaci three flavor medicine mixing and water addings decoct secondary, add for the first time 6 times of water gaging persons of frying in shallow oil 2 hours, adding for the second time 5 times of water gagings decocted 1.5 hours, collecting decoction filters, relative density was the thick paste of 1.25-1.30 when filtrate was concentrated into 80 ℃, at last with standby fine powder medicine, thick paste, Mel mixes plasticity ball piece, and divide and make seeds of a tung oil tree big honeyed pills, drying, sterilization back bottling seal patent medicine.

Theory of Chinese medical science is thought, nephropathy comes from deficiency of both the liver and kidney, incoordination between the spleen and stomach, Qi and blood deficiency, deficiency of kidney yin, stagnant blood stream knot, the five internal organs decline and dry up, be the lower limb weakness, the waist knee flaccidity, the phlegm retention of quenching one's thirst, weak breathe heavily more, weakness symptom such as cardiopalmus coma, in treatment nephropathy honeyed pill, the Radix Astragali has benefiting qi and raising yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, the promoting pus discharge and tissue regeneration strengthening effect, can obviously improve the antibody cell number, promote cellular immune function, promote the swollen protein of serum regulating liver-QI to upgrade, and blood glucose there is dual regulation, significantly the hemocytes increasing ratio can suppress the pathogenic change effect of virus on nephrocyte, cures mainly the internal injury overstrain, spleen lung interior-deficiency, have blood in stool, the disease of edema and Qi and blood deficiency; Semen Cuscutae has the kidney invigorating nourishing the liver, supports the function of flesh reinforcing YIN-essence, and myocardial ischemia is had tangible preventive and therapeutic effect, can obviously strengthen gonad function and immunologic function, cures mainly soreness of waist and knee joint, seminal emission, sexual impotence, quenches one's thirst, disease such as blurred vision tinnitus; Fructus Lycii has the function of tonifying liver, nourishing kidney, lung moistening, can improve body immunity and blood fat reducing, guarantor's lung, anti-fatty liver, hypoglycemic effect, cures mainly deficiency of both the liver and kidney, has a dizzy spell, soreness of waist and knee joint, impotence and seminal emission, cough due to consumptive disease, the taking fluids profusely of quenching one's thirst; Herba Taxilli has the function of invigorating the liver and kidney, bone and muscle strengthening, and blood pressure lowering, diuresis, anti-microbial effect are arranged, and cures mainly soreness of waist and knee joint, hemiplegia, the Light-headedness of limbs; Fructus Psoraleae has reinforcing the kidney and supporting YANG, helping inspiration to relieve asthma, warming spleen and stopping diarrha function, and the effect of heart failure resistance, antipathogen and inhibition leukopenia is arranged, and hepatocellular damage is had protective effect, cures mainly insufficiency of kidney-YANG, below element deficiency and cold, more than, the asthenia of both the spleen and kidney of dyspnea due to deficiency; Caulis Spatholobi has relaxing muscles and tendons to promote blood circulation, and the effect of the function of strongly invigorating QI and blood and energy blood vessel dilating, antiplatelet aggregation, promotion phosphorus metabolism cures mainly numb hand and foot, quadriplegia, rheumatic arthralgia; Caulis Sargentodoxae has the function of tonifying YANG thing, strong waist knee joint, promoting blood circulation and stopping pain, expelling wind and removing dampness, multiple virus there is high responsive bacteriostasis, cure mainly edema, blood deficiency, giddy, Squama Manis has blood circulation promoting and dispersing pathogen accumulation, routed hard, the dispelling the stagnated QI promoting the circulation of blood function of eliminating carbuncle, significant anticoagulation, antiinflammatory action are arranged, cure mainly blood stasis amenorrhea and cancerous protuberance; Cornu Cervi has kidney-replenishing, benefiting essence-blood, bone and muscle strengthening, promoting the circulation of blood repercussive function, can obviously increase the heart stroke volume, cures mainly the spinal column cold type of pain of suffering from a deficiency of the kidney, sexual impotence seminal emission; Radix Codonopsis has strengthening the spleen and tonifying the lung, supplementing QI for promoting the production of body fluid function, can strengthen human body stress ability and immunologic function, antiulcer, blood sugar lowering is arranged, alleviate hepatic steatosis, improves the effect of hepatic necrosis, cures mainly weakness of the spleen and stomach, limbs fatigue, cough and asthma due to lung deficiency, deficiency of both QI and blood; Herba Taraxaci has the function of heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, and multiple viral pathogenic bacteria is had resisting pathogenic microbes, antiulcer, antitumor, function of gallbladder promoting, hepatoprotective effect, cures mainly hepatitis, gastritis, enteritis and cancerous protuberance; Fructus Jujubae has tonifying the spleen and stomach, replenishing QI and blood, tranquilizing mind, and the function of transferring battalion to defend has hepatoprotective, muscle strength reinforcing, antineoplastic action, cures mainly weakness of the spleen and stomach, insufficiency of vital energy and blood, anorexia and loose stool, palpitation and insomnia, disharmony of nutrient QI with defensive QI; Cinnabaris have calm the nerves, calm the frightened, make eye bright, the antidotal function, calmness, hypnosis, diuresis are arranged, cure mainly vexed, insomnia, blurred vision, palpitation with fear; Alumen preparata is the Alumen classification, contains alkaline potassium aluminum sulfate, has sharp fecal and urinary functions, and more than ten kind of pathogenic bacterias such as staphylococcus aureus, Hemolytic streptococcus are all had inhibitory action, and the effect of powerful solidifying protein is arranged, and cures mainly rheumatism gonalgia, general edema with yellowish skin edema; Mel promptly is medicine in prescription, is again binding agent, has harmonizing the spleen and stomach, an effect of the pain relieving of getting a breathing space, clearing away lung-heat to relieve cough, loosening bowel to relieve constipation.In preparation in each pharmaceutically active ingredient in one, play the kidney tonifying diuresis altogether, invigorating QI to consolidate the body surface resistance, liver nourishing lung moistening, warming the spleen is good for the stomach and the effect of benefiting essence-blood, tranquilizing mind, blood stasis removing blood, tissue regeneration promoting blood, effectively treats acute and chronic nephritis, diabetic nephropathy, hypertensive nephropathy, comprehensive nephropathy and henoch Schonlein purpura nephritis.

The invention has the beneficial effects as follows: the scientific formulation novelty, preparation technology is easy, by the complementation of many medicine compositions, can reach kidney tonifying diuresis, invigorating QI to consolidate the body surface resistance, liver nourishing lung moistening, warming the spleen is good for the stomach and the curative effect of benefiting essence-blood, tranquilizing mind, blood stasis removing blood, tissue regeneration promoting blood.Possess sterilization, bacteriostasis simultaneously, can nourish liver, spleen, stomach, lung, improve body immunity, have curative effect simultaneously, can effectively treat all kinds of nephropathy, especially henoch Schonlein purpura nephritis is had special efficacy mixing a disease.For a long time to nephrotic's observation of curative effect, take medicine twice by prescription drugs every day, each 30, medication 100 days.Curative effect determinate standard is that (1) is alleviated fully: symptom and sign complete obiterations such as edema, continuous three the urine protein examination feminine genders in treatment back, or 24 hours or urine albumen amount continue less than 0.1g, urine erythrocyte disappears under the high power lens, the Urine sediments analyzer counting is normal, serum albumin returns to more than the 35g/L, and blood T-CHOL, triglyceride are normal substantially, and renal function is normal; (2) the basic alleviation: symptom such as edema and sign disappear substantially, treatment back urine protein examination reduces more than 1～2 "+" number, the twenty-four-hour urine protein quantification continues between 0.1～0.5g, serum albumin is between 30～35g/L, blood T-CHOL, triglyceride be near normal, and renal function normally or normal substantially (differ be no more than 15% with normal value); (3) effective: symptom such as edema and sign are clearly better, and urine protein examination continuous decrease 1 "+" number, or the twenty-four-hour urine protein content continues between 0.51～2g is compared before blood T-CHOL and triglyceride and the treatment and made moderate progress, and renal function makes moderate progress; (4) invalid: symptom such as edema and sign do not have and are clearly better, twenty-four-hour urine protein quantification＞2g, and renal function does not have improvement.Observe adult patient (nephrotic syndrome) 160 examples altogether, alleviate (recovery from illness) 110 examples fully, account for 68.8%, basic (produce effects) 12 examples of alleviating account for 7.5%, and effective 15 examples account for 9.4%, and invalid 22 examples only account for 14.3%.

Specific embodiments

1, raw material for standby

(1) get Fructus Psoraleae and drink raw sheet, put when frying to cracker in the pot with high heat, it is standby that taking-up cools the back weighing.

(2) get Fructus Lycii and drink raw sheet, put in the pot with slow fire and fry when there is focal spot point on the surface, take out cool after weighing standby.

(3) get Semen Cuscutae and drink raw sheet, put in the pot and fry to little Huang with slow fire, when cracker was arranged, it is standby that taking-up cools the back weighing.

(4) getting Mel, to be heated into refined honey (old honey) back weighing standby.

(5) by existing prepared slices of Chinese crude drugs standard get all the other Chinese crude drugs respectively behind well sifteds weighing standby.

2, the preparation technology of the pure Chinese medicine pill of treatment nephropathy

(1) get Cinnabaris, Alumen preparata respectively porphyrize be mixed into the fine powder medicine after crossing 80 mesh sieves.

(2) get and pulverized 80 mesh sieves after the Radix Astragali, Semen Cuscutae, Fructus Lycii, Herba Taxilli, Fructus Psoraleae, Caulis Spatholobi, Caulis Sargentodoxae, Squama Manis, Cornu Cervi nine flavor medicines mix and become the fine powder medicine.

(3) merge fine powder medicine mixing.

(4) will tail over medicinal residues and Fructus Jujubae, Radix Codonopsis, Herba Taraxaci three flavor medicines decoct with water secondary, adding for the first time 6 times of water gagings decocted 2 hours, add for the second time 5 times of water gagings and decocted 1.5 hours, collecting decoction filters, and filtrate is concentrated into the thick paste that relative density is 1.25～1.30 (80 ℃).

(5) fine powder medicine, thick paste, refined honey are mixed plasticity ball piece, and divide and to make seeds of a tung oil tree big honeyed pills, dry below 80 ℃, be sub-packed in behind the β ray sterilizing seal in the vial patent medicine.

The also available lard stearin of this preparation substitutes refined honey and makes oily ball, and curative effect is constant.

Claims (2)

1, the close ball of the pure Chinese medicine of a kind of treatment nephropathy, it is characterized in that: preparing its raw materials of effective components gross weight is 1180 grams, is made up of the Radix Astragali 50 grams, Semen Cuscutae 75 grams, Fructus Lycii 50 grams, Herba Taxilli 60 grams, Fructus Psoraleae 60 grams, Caulis Spatholobi 75 grams, Caulis Sargentodoxae 60 grams, Squama Manis 40 grams, Cornu Cervi 50 grams, Radix Codonopsis 50 grams, Herba Taraxaci 50 grams, Fructus Jujubae 30 grams, Alumen preparata 100 grams, Cinnabaris 30 grams and Mel 400 grams.

2, the preparation method of the pure Chinese medicine pill of the described treatment nephropathy of claim 1, it is characterized in that: get Cinnabaris earlier, Alumen preparata porphyrize is respectively crossed 80 mesh sieves and is become fine powder, get the Radix Astragali again, Semen Cuscutae, Fructus Lycii, Herba Taxilli, Fructus Psoraleae, Caulis Spatholobi, Caulis Sargentodoxae, Squama Manis, Cornu Cervi nine flavor medicines mixing were pulverized 80 mesh sieves and were become fine powder, again with Cinnabaris, it is standby that the Alumen preparata fine powder is mixed into the fine powder medicine, to tail over medicinal residues and Fructus Jujubae again, Radix Codonopsis, Herba Taraxaci three flavor medicine mixing and water addings decoct secondary, adding for the first time 6 times of water gagings decocted 2 hours, adding for the second time 5 times of water gagings decocted 1.5 hours, collecting decoction filters, relative density was the thick paste of 1.25-1.30 when filtrate was concentrated into 80 ℃, at last with standby fine powder medicine, thick paste, Mel mixes plasticity ball piece, and divide and make seeds of a tung oil tree big honeyed pills, drying, sterilization back bottling seal patent medicine.