CN100421703C

CN100421703C - Gout granules

Info

Publication number: CN100421703C
Application number: CNB2006100881033A
Authority: CN
Inventors: 朱良春
Original assignee: Individual
Current assignee: Individual
Priority date: 2006-06-26
Filing date: 2006-06-26
Publication date: 2008-10-01
Anticipated expiration: 2026-06-26
Also published as: CN1895522A

Abstract

A Chinese medicine 'Gout particle' for treating gout is prepared from 7 Chinese-medicinal materials including China root, silkworm excrement, plantain herb, clematis root, etc.

Description

Gout granules

Technical field:

The present invention relates to a kind of medicine for the treatment of gout.

Background technology:

Gout is the disease due to a kind of purine metabolic disturbance.Primary gout arthritis and high protein recipe etc. have substantial connection, and be more rare in China in the past.The European and American countries sickness rate is about 2/1000ths to three, and certain areas are up to 3/1000ths, because nutrition improvement and average life prolong, the gout sickness rate also rises year by year over past ten years in China.(1) (2) primary gout arthritis is improper as preventing and treating, not only acute attack has very big misery, and easily cause serious consequences such as joint deformity, renal calculus, renal function injury, renal insufficiency person prognosis heterodyne, often with obesity, hyperlipidemia, hyperglycemia, hypertension tendency, these also are the precipitating factors that forms diabetes, atherosclerosis, coronary heart disease, renal arteriolosclerosis, cerebral arteriosclerosis to patient with gout.In treatment, Western medicine colchicine pain relieving commonly used so far, allopurinol suppresses uricopoiesis, probenecid increases urate excretion, in taking except that gastrointestinal reaction such as nausea,vomiting,diarrhea occurring, can be to the inhibition of bone marrow, or cause leucocytes reduction, and the infringement of hepatic and renal function.After allopurinol is taken, heating can be arranged, allergic rash, stomachache, diarrhoea.Leukocyte and thrombocytopenia, even liver function injury, the idol dermatitis that necroses, and the outbreak of uric acid transitivity gout can take place during the medication.(2) along with the continuity of medicine time, the patient grows with each passing day to the side effect and the feared state of mind of said medicine, and in 307 routine patient with gout, toxic and side effects person's 62 examples (accounting for 32.98%) take place for clothes allopurinol, colchicine treatment 188 examples according to reports, wherein vomiting, 26 examples of suffering from diarrhoea (accounting for 13.83%); Gastrorrhagia 4 examples (accounting for 2.13%) leukopenia, thrombocytopenia 4 examples (accounting for 2.13%); Bring out heart disease 1 example (accounting for 0.53%); Exfoliative dermatitis 2 examples (accounting for 1.06%), alopecia 2 examples (accounting for 1.06%), dizzy, weak, anasarca 5 examples (accounting for 2.66%); Because of hepatic and renal function injure, exfoliative dermatitis are rescued 4 examples.Account for 2.13%); The patient of 60 routine toxicities all takes medicine by doctor's advice, occurs in 2～3 week backs mostly, and (2) this shows to seek and a kind ofly can drain uric acid to suppress uric acid synthetic, again can reducing swelling and alleviating pain, and the new Chinese patent medicine of safe without toxic side effect, imperative.

Summary of the invention:

The object of the present invention is to provide a kind of effective gout granules of gout for the treatment of.

Technical solution of the present invention is:

A kind of gout granules is characterized in that: the raw material by following weight portion is made:

Rhizoma Smilacis Glabrae 12～25% Bombyx mori L.s 15～20%

Radix Clematidis 15～20% Rhizoma Dioscoreae Hypoglaucaes 12～20%

Rhizoma Paridis 6～20% Radix Cynanchi Paniculatis 8～20%

Semen Plantaginis 4～8%.

It is effective that the present invention treats gout, and clinical trial proves to have the obvious treatment effect, and have no side effect.Show through animal experiment, behind the rat paw subcutaneous injection uric acid sodium turbid solution, the very fast hyperemia in the visible part of naked eyes reddens, but swelling is not fairly obvious in one hour, the swelling of foot sole of the foot portion peaked about the injection back in 4～6 hours, disappearing of the pedal swelling of administration (the present invention) group rat is obviously fast than model group (not giving any medicine), and compares with the colchicine group, and each dosage group of ventilation electuary is also all not inferior aspect detumescence.Clinical treatment shows that 47% patient was difficult for outbreak in 2～5 years.

Model case:

Medical record one: the king * *, man, 48 years old, people from Nantong City.

Suffer from gout and watch year, because work relationship is often treated blood uric acid 672umol/L with courtesy, blood fat: triglyceride 5.6mmol/L, two whole female toes, the frequent repeatability congestion and swelling pain of knee joint, introduce diagnosis and treatment through friend, body is plump, yellow, thin and slightly greasy fur, the matter purple, soft pulse, this is a turbid damp stasis of blood resistance passages through which vital energy circulates, numbness is closed unfavorable, control and to let out turbid blood stasis dispelling, the tonneau passages through which vital energy circulates.

From taking this medicine, after January, arthralgia is shown effect repeatedly and is occurred, continue after ask someone again to buy, take March altogether, blood uric acid, triglyceride are all reduced to normally during health check-up, very happiness.

Follow up a case by regular visits to after 1 year, be careful in one's diet at ordinary times, have and take this medicine 2 bags (every bag 10 grams) after the dinner party, gout is outbreak always.

(this routine patient is that gout merges hyperlipidemia and since used let out this medicine of turbid blood stasis dispelling after, not only uric acid is had Excretion, and triglyceride is also had the ester of falling effect.)

Case two: Lee *, woman, 53 years old, people from Suzhou City.

Suffered from gouty arthritis 10 years, and took probenecid, allopurinol treatment for a long time, because of the anaphylaxis drug withdrawal.With colchicine, slow its hardship of narcaricin, blood uric acid fluctuates about 250umol/L always since nearly 1 year.Leave hospital pain relief after because of gout, arthralgia hospitalization this year, and still two fingers, the palm, buccal, auricle have the gout calculus, arthralgia swelling, dysstasia is obeyed 3 of colchicines every day, indigestion and loss of appetite, anorexia, diarrhoea, xerostomia and hardship, long-term oral ulcer, thick, yellow and greasy fur, thready pulse moistens, and this is the time of turbid arthralgia due to blood stasis, and taste are impaired, control and should let out turbid blood stasis dispelling, spleen invigorating helps fortune.

Two finger-joint rednesses disappear after taking this medicine, and knee joint can be squatted down.Only spiritlessness and weakness, indigestion and loss of appetite, xerostomia and hardship, oral ulcer.Thick fur is yellow greasy, and matter is pale purple, and thready pulse moistens, and continues and goes on it by former method.

Can participate in expedition, free movement of the bowels after several months.Only xerostomia and hardship, oral ulcer.Tongue is greasy in vain, thready pulse moistens, continuously go on it by former method.Ear corridor calculus disappears behind the medicine, very happiness, and spirit is clearly better, and Na Gu is also fragrant, can orthobiosis, white and thin fur is greasy, and the little string of thready pulse is continuously consolidated it by former method.This medicine bag every days 2 (every bag 10 grams) adheres to taking.

Follow up a case by regular visits to: this medicine adheres to that always every days 2, bag was taken, and gout remains dormant so far, and blood uric acid is normal.

The invention will be further described below in conjunction with embodiment.

The specific embodiment:

Embodiment 1:

(1) Rhizoma Smilacis Glabrae 12%, Bombyx mori L. 20%, Radix Clematidis 20%, Rhizoma Dioscoreae Hypoglaucae 18%, Rhizoma Paridis 6%, Radix Cynanchi Paniculati 20%, Semen Plantaginis 4% weight portion are decocted with water, filter, filtrate is condensed into clear paste;

(2) clear paste is made granule by making particulate conventional method.(can be by clear paste: dextrin: Icing Sugar=1: 2: 1 weight ratio)

(3) can carry out disinfection, pack by every bag 9 gram.

During use, can take for 3 times on the one by each 1～2 bag.

Embodiment 2:

The amount ratio of each component (weight) is:

Rhizoma Smilacis Glabrae 19%, Bombyx mori L. 18%, Radix Clematidis 18%, Rhizoma Dioscoreae Hypoglaucae 12%, Rhizoma Paridis 20%, Radix Cynanchi Paniculati 8%, Semen Plantaginis 5% weight portion.All the other are with embodiment 1.

Embodiment 3:

The amount ratio of each component (weight) is:

Rhizoma Smilacis Glabrae 25%, Bombyx mori L. 15%, Radix Clematidis 15%, Rhizoma Dioscoreae Hypoglaucae 20%, Rhizoma Paridis 12%, Radix Cynanchi Paniculati 9%, Semen Plantaginis 4% weight portion.All the other are with embodiment 1.

Embodiment 4:

The amount ratio of each component (weight) is:

Rhizoma Smilacis Glabrae 13%, Bombyx mori L. 19%, Radix Clematidis 17%, Rhizoma Dioscoreae Hypoglaucae 17%, Rhizoma Paridis 13%, Radix Cynanchi Paniculati 15%, Semen Plantaginis 6% weight portion.All the other are with embodiment 1.

Claims

1. granule for the treatment of gout is characterized in that: prepare this particulate crude drug and consist of:

Rhizoma Smilacis Glabrae 12～25% Bombyx mori L.s 15～20%

Radix Clematidis 15～20% Rhizoma Dioscoreae Hypoglaucaes 12～20%

Rhizoma Paridis 6～20% Radix Cynanchi Paniculatis 8～20%

Semen Plantaginis 4～8%.