CN111588818A

CN111588818A - Oral liquid for treating gout

Info

Publication number: CN111588818A
Application number: CN202010354445.5A
Authority: CN
Inventors: 赵升瑞; 赵景颢
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-04-29
Filing date: 2020-04-29
Publication date: 2020-08-28

Abstract

The invention discloses gout oral liquid, which is prepared by mixing a component A for strengthening body resistance and reinforcing primordial qi, nourishing yin and tonifying yang, improving the immunity of a human body, increasing the energy for promoting metabolism, reducing the generation of uric acid, a component B for reducing the content of uric acid, a component C for dispelling wind heat and relieving swelling and pain, a component D for dispelling wind cold and relieving swelling and pain, inducing diuresis, accelerating the excretion of uric acid, reducing the content of uric acid, a component E for relieving swelling and pain, a component F for strengthening spleen and dispelling wind-damp and relieving pain and excreting and discharging pathogenic heat according to a certain volume ratio; the oral liquid is a pure traditional Chinese medicine preparation, has no drug dependence, no toxic or side effect and good curative effect.

Description

Oral liquid for treating gout

Technical Field

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to gout oral liquid.

Background

Gout is also called hyperuricemia, which is a disease caused by accumulation of uric acid due to purine metabolic disorder; the symptoms of gout are: (1) blood: the content of uric acid in blood in a body is too high, the acid-base balance of an organism is broken, and acidosis is caused; the blood viscosity is increased due to the increase of the blood concentration, the blood circulation resistance is further increased, and the influence on various human organs is realized; (2) a joint: uric acid accumulates in the joints to cause arthritis, and the joints are red, swollen and painful. Migratory arthralgia, arthralgia and erratic wandering caused by excessive wind; the patients with excessive cold are arthralgia, stiff joints and pain in certain places; the patients with excessive dampness are marked by arthralgia, numbness of joints and muscles and swelling; the predominant heat pathogen is pyretic arthralgia, red, swollen and burning joints, pain and tenderness; uric acid forms urate deposition crystals in joints to form gout stones; uric acid continuously stimulates joint skeleton proliferation to enlarge and deform the joint skeleton; (3) the water in the body is increased, so that the weight is increased and the walking is slow; (4) qi deficiency, energy decline, tiredness and weakness; (5) renal function gradually decreases and finally renal failure.

The western medicine pathogenesis of gout has the following aspects: (1) the immunity is low, and allergy occurs in vivo, so that the local temperature in vivo is increased, the capillary permeability is increased, and the local glandular secretion is increased; repeated attacks of internal allergy lead to the fact that most of energy in the body is converted into heat energy, the internal energy is excessively consumed, the energy production is insufficient, the energy for pushing a normal body to run is insufficient, the heat is insufficient, and a patient gradually shows slow metabolism, dysfunction of internal organs, fatigue and intolerance of cold; (2) uric acid is produced much, and the following reasons are mainly included: (ii) excessive purine intake; disorders of purine metabolism; uric acid is discharged little, mainly because sweat is little and urine is little.

The traditional Chinese medicine pathogenesis of gout has the following aspects: (1) congenital deficiency of primordial qi caused by congenital deficiency of innate essence; acquired malnutrition and deficiency of acquired primordial qi can cause viscera dysfunction as the basis of morbidity; (2) exogenous pathogenic factors and traumatic injury are the exogenous causes of the disease, and damp-heat, turbid phlegm and blood stasis are the characteristics of the disease; (3) excessive uric acid belongs to damp turbidity, the damp turbidity is generated due to the dysfunction of the spleen in transportation, the dysfunction of the kidney in clearing and damp turbidity causes damp turbidity excretion disorder, and in addition, the damp turbidity flows into joints and muscles due to excessive drinking and overeating, overstrain and the like, so that the disease is caused.

At present, a lot of western medicines for treating gout are taken orally, and the western medicines with good effect are mainly colchicine tablets, but the medicine has great side effect, and the medicine needs to be taken for a long time to reduce the content of uric acid, so that the taking time is too long, the liver and the kidney are injured, the renal failure is caused in the later period, and the life has to be maintained by dialysis. There are also many important formulas for treating gout in traditional Chinese medicine, and the effects of promoting blood circulation to remove blood stasis, eliminating dampness and relieving pain are mainly achieved to prevent the uric acid content from increasing too fast, so that the side effects are small, but the function of reducing uric acid is poor. Therefore, the gout can not be cured completely by the existing traditional Chinese medicine or western medicine.

Disclosure of Invention

In order to solve the problems in the prior art, the invention provides gout oral liquid which is a pure traditional Chinese medicine preparation, has mild medicine property, no medicine dependence and no toxic or side effect.

The preparation is mainly used for treating gouty arthritis from the following aspects:

1. cultivating the root, consolidating the vitality, nourishing yin and tonifying yang; improving immunity, and increasing energy for promoting metabolism.

2. Inhibiting xanthine oxidase activity; according to the principle of acid-base neutralization, the alkaloid is used for neutralizing uric acid in blood, so that the uric acid content is reduced; dissolving joint urate crystal and reducing uric acid content.

3. Dispel wind-heat, resolve swelling and alleviate pain.

4. Dispel wind-cold, resolve swelling and alleviate pain.

5. Promoting urination, accelerating excretion of uric acid, reducing uric acid content, and relieving swelling and pain.

6. Strengthen spleen to dispel wind-damp, moisten intestines to relieve constipation and alleviate pain.

Therefore, the applicant develops the gout oral liquid which can reduce the content of uric acid, eliminate dampness, promote blood circulation, remove blood stasis and relieve pain, and gradually convert disordered purine metabolism in a patient body into normal purine metabolism, so that gout is thoroughly cured, and the gout oral liquid is small in side effect and remarkable in curative effect.

The gout oral liquid is prepared by mixing the following components in percentage by volume, adding 4-6% of white spirit, sealing and storing for 15-25 days: the component A is as follows: 2-3; and (B) component: 5-6; and (C) component: 1 to 6; and (B) component D: 1 to 6; and (E) component E: 3-4; and (F): 3-6;

the component A is prepared from 15-25g of epimedium, 4-6g of ginseng, 45-55g of astragalus root, 8-12g of angelica, 12-18g of fried white peony root, 15-25g of eucommia bark and 15-25g of salvia miltiorrhiza; the preparation method comprises the following steps: mixing the epimedium herb, the ginseng, the astragalus mongholicus, the angelica sinensis, the fried white paeony root, the eucommia ulmoides and the salvia miltiorrhiza, grinding the mixture to particles of 60 meshes to 80 meshes, decocting the particles in water for 20 to 25min, mixing decoction dregs and decoction, adding 4 to 6 percent of white spirit, sealing and soaking the mixture for 15 to 20 days to obtain a component A;

the component B is prepared from 25-35g of smilax china, 25-35g of turmeric, 25-35g of cape jasmine, 15-25g of chicory, 15-25g of yam rhizome, 25-35g of glabrous greenbrier rhizome, 12-18g of Chinese starjasmine stem, 5-7g of prepared common monkshood mother root, 5-7g of ephedra herb, 8-12g of Indian iphigenia bulb, 15-25g of tinospora sinensis and 15-25g of lily; the preparation method comprises the following steps: mixing the smilax china, the turmeric, the gardenia, the chicory, the yam rhizome, the glabrous greenbrier rhizome, the Chinese starjasmine stem, the prepared common monkshood mother root, the ephedra herb, the edible tulip, the tinospora sinensis and the lily, grinding the mixture into particles of 60 meshes to 80 meshes, decocting the particles in water for 20 min to 25min, and filtering dregs to obtain decoction; adding appropriate amount of Chinese liquor into the residue, sealing and soaking for 15-20 days, filtering and precipitating to obtain soaking solution; mixing the decoction and the soak solution to obtain the component B;

the component C is prepared from 12-18g of ash bark, 12-18g of fringed pink, 12-18g of phellodendron, 12-18g of paris rhizome, 25-35g of honeysuckle and 12-18g of coptis chinensis; the preparation method comprises the following steps: mixing the cortex fraxini, the dianthus superbus, the cortex phellodendri, the manyleaf paris rhizome, the honeysuckle and the coptis chinensis, grinding the mixture to particles of 60 meshes to 80 meshes, decocting the particles in water for 20 to 25min, mixing the decoction dregs and the decoction, adding 4 to 6 percent of white spirit, sealing and soaking the mixture for 15 to 20 days to obtain a component C;

the component D is prepared from 8-12g of suberect spatholobus stem and 4-6g of cassia twig; the preparation method comprises the following steps: mixing the caulis spatholobi and the cassia twig, grinding the mixture into particles of 60 meshes to 80 meshes, decocting the particles in water for 20 min to 25min, mixing the decoction dregs and the decoction, adding 4 percent to 6 percent of white spirit, sealing and soaking the mixture for 15 days to 20 days to obtain a component D;

the component E is prepared from 25-35g of semen plantaginis, 25-35g of talcum, 8-12g of polyporus, 8-12g of nidus vespae, 8-12g of gentiana macrophylla and 8-12g of rhizoma alismatis; mixing the plantain seed, the talc, the grifola, the nidus vespae, the gentiana macrophylla and the alisma orientale, grinding the mixture to particles of 60 meshes to 80 meshes, decocting the particles in water for 20 to 25min, mixing the decoction dregs and the decoction, adding 4 to 6 percent of white spirit, sealing and soaking the mixture for 15 to 20 days to obtain a component E;

the component F is prepared from 8-12g of pangolin scales, 25-35g of raw coix seeds, 45-55g of glabrous greenbrier rhizome, 15-25g of talcum, 15-25g of medicinal cyathula root, 25-35g of gypsum, 8-12g of siegesbeckia orientalis, 8-12g of clematis root and 8-12g of safflower; the preparation method comprises the following steps: mixing the pangolin scales, the raw coix seeds, the glabrous greenbrier rhizome, the talc, the medicinal cyathula root, the gypsum, the siegesbeckia orientalis, the clematis root and the safflower, grinding the mixture into particles of 60 meshes to 80 meshes, decocting the particles in water for 20 min to 25min, mixing the decoction dregs and the decoction, adding 4 percent to 6 percent of white spirit, sealing and soaking the mixture for 15 days to 20 days to obtain the component F.

In one embodiment of the invention, the gout oral liquid is prepared by mixing the following components in percentage by volume, adding 4% -6% of white spirit, sealing and storing for 15-25 days: a, B, C, E, F, 2, 5, 6, 1, 4 and 4.

In one embodiment of the invention, the gout oral liquid is prepared by mixing the following components in percentage by volume, adding 4% -6% of white spirit, sealing and storing for 15-25 days: and A, B, C, E, F, 3, 6, 1, 6, 3 and 3.

In one embodiment of the invention, the gout oral liquid is prepared by mixing the following components in percentage by volume, adding 4% -6% of white spirit, sealing and storing for 15-25 days: and A, B, C, E, F, 3, 6, 2, 3 and 6.

The invention has the beneficial effects that:

1. the gout oral liquid can consolidate constitution and cultivate vigor, nourish yin and tonify yang, improve human immunity and increase energy for promoting metabolism; simultaneously can dispel wind-damp, dispel wind-cold, dispel wind-heat, detumescence and acesodyne;

2. can reduce the generation of uric acid, reduce the content of uric acid and relax bowel;

3. the invention is a pure Chinese medicinal preparation, has no medicament dependence, no toxic or side effect and good curative effect.

Detailed Description

The present invention will be described in further detail with reference to specific examples, but the embodiments of the present invention are not limited thereto.

The embodiment of the invention provides gout oral liquid which is prepared by mixing the following components, adding 5% of grain liquor with the alcohol content of more than 60 degrees, and sealing and storing for 20 days.

The component A is prepared from 20g of epimedium, 5g of ginseng, 50g of astragalus root, 10g of angelica, 15g of fried white peony root, 20g of eucommia bark and 20g of salvia miltiorrhiza; the preparation method comprises the following steps: mixing herba Epimedii, Ginseng radix, radix astragali, radix Angelicae sinensis, radix Paeoniae alba preparata, Eucommiae cortex, and Saviae Miltiorrhizae radix, grinding into 60-80 mesh granules, decocting with water for 20-25min, mixing the residue and decoction, adding 5% of grain liquor with alcoholicity of above 60%, sealing, and soaking for 15 days to obtain component A; the component A is used for consolidating body constitution, nourishing yin, tonifying yang, enhancing immunity, and increasing energy for promoting metabolism.

The component B is prepared from 30g of chinaroot greenbrier rhizome, 30g of turmeric, 30g of cape jasmine fruit, 20g of chicory, 20g of yam rhizome, 30g of glabrous greenbrier rhizome, 15g of Chinese starjasmine stem, 6g of prepared common monkshood mother root, 6g of ephedra herb, 10g of Indian iphigenia bulb, 20g of tinospora sinensis and 20g of lily bulb; the preparation method comprises the following steps: mixing rhizoma Smilacis chinensis, Curcuma rhizome, fructus Gardeniae, herba Cichorii, rhizoma Dioscoreae Septemlobae, rhizoma Smilacis Glabrae, caulis Trachelospermi, radix Aconiti Preparata, herba Ephedrae, Pseudobulbus Cremastrae seu pleiones, caulis tinosporae, and Bulbus Lilii, grinding into 60-80 mesh granules, decocting in water for 20-25min, and filtering the residue to obtain decoction; adding appropriate amount of grain liquor with alcohol content of above 60 ° into the residue, sealing and soaking for 15 days, filtering and precipitating to obtain soaking solution; fully mixing the decoction and the soak solution to obtain a component B; the component B is used for reducing the generation of uric acid and reducing the content of uric acid. The medicine in the component B contains flavonoid glycoside, resveratrol and alkaloid, the flavonoid glycoside and the resveratrol can reduce the activity of xanthine oxidase, the xanthine oxidase is used for oxidizing purine to convert the purine into uric acid, and after the activity of the xanthine oxidase is reduced, the speed of converting the purine into the uric acid is reduced, so that the generation of the uric acid is reduced; the alkaloid can neutralize uric acid, reduce uric acid content, and prevent acidosis.

It should be noted that the amount of grain liquor added in the component B is just less than the amount of herb residue, and the embodiment of the present invention is not specifically limited herein.

The component C is prepared from 15g of ash bark, 15g of fringed pink, 15g of golden cypress, 15g of paris rhizome, 30g of honeysuckle and 15g of coptis chinensis; the preparation method comprises the following steps: mixing cortex Fraxini, herba Dianthi, cortex Phellodendri, rhizoma paridis, flos Lonicerae, and Coptidis rhizoma, grinding to 60-80 mesh granules, decocting in water for 20-25min, mixing the residue and decoction, adding 5% of 60 ° above grain liquor, sealing, and soaking for 15 days to obtain component C; the component C is used for dispelling wind heat, relieving swelling and pain.

The component D is prepared from 10g of suberect spatholobus stem and 5g of cassia twig; the preparation method comprises the following steps: mixing caulis Spatholobi and ramulus Cinnamomi, grinding into 60-80 mesh granules, decocting with water for 20-25min, mixing the residue and decoction, adding 5% 60 ° above grain Chinese liquor, sealing and soaking for 15 days to obtain component D, which is used for dispelling pathogenic wind cold, and relieving swelling and pain.

The component E is prepared from 30g of plantain seed, 30g of talcum, 10g of grifola, 10g of nidus vespae, 10g of gentiana macrophylla and 10g of alisma orientale; mixing semen plantaginis, pulvis Talci, Polyporus, nidus Vespae, radix Gentianae Marcrophyllae and Alismatis rhizoma, grinding to 60-80 mesh granules, decocting with water for 20-25min, mixing the residues and decoction, adding 5% of grain liquor with alcoholicity of 60% or above, sealing and soaking for 15 days to obtain component E for promoting urination, accelerating excretion of uric acid, reducing uric acid content, and relieving swelling and pain.

The component F is prepared from 10g of pangolin scales, 30g of raw coix seeds, 50g of glabrous greenbrier rhizome, 20g of talcum, 20g of medicinal cyathula root, 30g of plaster stone, 10g of herba siegesbeckiae, 10g of clematis root and 10g of safflower; the preparation method comprises the following steps: mixing squama Manis, Coicis semen, rhizoma Smilacis Glabrae, pulvis Talci, radix Cyathulae, Gypsum Fibrosum, Siegesbeckiae herba, radix Clematidis, and Carthami flos, grinding into 60-80 mesh granules, decocting in water for 20-25min, mixing the residues and decoction, adding 5% of grain liquor with alcoholicity of 60 ° above, sealing, soaking for 15 days to obtain component F, and using component F for invigorating spleen, dispelling pathogenic wind, relieving pain, and removing pathogenic heat.

It should be noted that the grain liquor added in the invention provides the function of preservation and freshness, and 5% of the grain liquor is relative to the volume of the finally obtained medicament, for example, 100mL of the finally obtained medicament needs to be added with 5mL of the grain liquor for preservation and freshness.

Aiming at wind-heat gout, the gout oral liquid is prepared by mixing the following components in percentage by weight, adding 5% of grain liquor with the alcohol content of more than 60 degrees, sealing and storing for 20 days, wherein A: B: C: D: E: F: 2:5:6:1:4: 4.

Aiming at wind-cold gout, the gout oral liquid is prepared by mixing the following components in percentage by weight, adding 5% of grain liquor with the alcohol content of more than 60 degrees, sealing and storing for 20 days, wherein A is B, C is D, E is F is 3, 6, 1, 6, 3 and 3.

Aiming at the gout of the rheumatism type, the gout oral liquid is prepared by mixing the following components in percentage by weight, adding 5% of grain liquor with the alcohol content of more than 60 degrees, sealing and storing for 20 days, wherein A is B, C, D, E, F is 3, 6, 2, 3 and 6.

According to the formula of the traditional Chinese medicine, the treatment principle of paying attention to yin-yang balance in the traditional Chinese medicine is adopted, and the symptom of damp-heat in the body of a patient can be caused due to excessive uric acid in the body of the patient when gout is caused, so that when gout with wind-heat type is treated, the component F is added to dispel the dampness in the body of the patient, and the component D is added to prevent the phenomenon of cold in the body of the patient caused by excessive heat removal in the treatment process; when treating wind-cold type gout, the component F is added to remove dampness in a patient body, and the component C is added to prevent the occurrence of internal heat phenomenon of the patient caused by excessive cold removal in the treatment process; when treating wind-damp type gout, because the dampness is also mixed with cold and heat, the component C is added to dispel the redundant heat in the body of the patient, and the component D is added to dispel the redundant cold in the body of the patient.

The treatment scope of the invention is as follows: gout.

The gout oral liquid is used for treating the root cause of a disease, and the gout external cream is used for treating the symptoms.

The usage and dosage of the invention are as follows:

1. adult male patients with robust constitution: 50-100 mL/day, 15-30mL oral liquid in the morning, and 500-600mL water, wherein honey can be added to season to have proper taste, and water is added while drinking; 15-30mL in the afternoon and 20-40mL in the evening, the drinking method is the same as in the morning, and two months are taken as a treatment course.

2. Weak male patients and healthy adult female patients: 30-50 mL/day, 10-15mL oral liquid in the morning, and 500-600mL water, wherein honey can be added to season to have proper taste, and water is added while drinking; 10-15mL in the afternoon and 10-20mL in the evening, the drinking method is the same as in the morning, and two months are taken as a treatment course.

3. Juvenile patients and frail female patients: adding 500-600mL of water into 10-30 mL/day and 3-10mL of oral liquid in the morning, optionally adding Mel for flavoring to obtain a proper taste, and adding water while drinking; 3-10mL in the afternoon and 4-10mL in the evening, and the drinking method is the same as in the morning, and two months are taken as a treatment course.

4. The elderly patients: adding 200mL of water into 5-15 mL/day and 1.5-5mL of oral liquid in the morning, optionally adding Mel for flavoring to obtain a suitable taste, and adding water while drinking; 1.5-5mL in the noon and 2-5mL in the evening, and the drinking method is the same as in the morning, and two months are taken as a treatment course.

It should be noted that honey is not added when patients allergic to honey and diabetics take the medicine orally.

It should be noted that the purpose of adding water when the oral liquid is taken is to reduce the concentration of alcohol in the oral liquid so as to prevent individual patients from alcohol allergy and facilitate taking, and because the concentration of the oral liquid is very high, the efficacy of the medicine is not affected by adding water.

The results of clinical observation of the sanitary station of WeiBin ZhongTanshu district of Baoji city and the WeiBin Yindaokada clinic of Baoji city are as follows:

the cure in the table indicates that all symptoms disappear and no recurrence occurs after the cure is over and the report is back; effective means that the disease is already improving in the treatment stage; the oral liquid has a treatment course of two months.

The gout oral liquid is used together with gout arthritis external cream, and generally continuously treats for 3 courses in one year, and if the gout is not recovered, the gout oral liquid is treated in the next year.

The invention can achieve the following beneficial effects:

The foregoing is a more detailed description of the invention in connection with specific preferred embodiments and it is not intended that the invention be limited to these specific details. For those skilled in the art to which the invention pertains, several simple deductions or substitutions can be made without departing from the spirit of the invention, and all shall be considered as belonging to the protection scope of the invention.

Claims

1. An oral liquid for treating gout, which is characterized in that,

2. The gout oral liquid of claim 1, wherein the gout oral liquid is prepared by mixing the following components in volume ratio, adding 4% -6% of white spirit, sealing and storing for 15-25 days: a, B, C, E, F, 2, 5, 6, 1, 4 and 4.

3. The gout oral liquid of claim 1, wherein the gout oral liquid is prepared by mixing the following components in volume ratio, adding 4% -6% of white spirit, sealing and storing for 15-25 days: and A, B, C, E, F, 3, 6, 1, 6, 3 and 3.

4. The gout oral liquid of claim 1, wherein the gout oral liquid is prepared by mixing the following components in volume ratio, adding 4% -6% of white spirit, sealing and storing for 15-25 days: and A, B, C, E, F, 3, 6, 2, 3 and 6.