CN107715014A - A kind of Chinese medicine composition for gout and preparation method thereof - Google Patents

A kind of Chinese medicine composition for gout and preparation method thereof Download PDF

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Publication number
CN107715014A
CN107715014A CN201711046475.4A CN201711046475A CN107715014A CN 107715014 A CN107715014 A CN 107715014A CN 201711046475 A CN201711046475 A CN 201711046475A CN 107715014 A CN107715014 A CN 107715014A
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China
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parts
root
radix
gout
chinese
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蒋秋月
香钰茂
陈彦
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Nanning City Enyuan Health Science And Technology Co Ltd
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Nanning City Enyuan Health Science And Technology Co Ltd
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    • A61K36/18—Magnoliophyta (angiosperms)
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Abstract

The present invention discloses a kind of Chinese medicine composition for gout, includes the raw material of following parts by weight：20 40 parts of turtle shell (system),15 25 parts of oyster (forging),10 20 parts of mantis egg-case,10 20 parts of radix stellariae dichotomae,18 30 parts of the red sage root,10 20 parts of Gorgon fruit (stir-fry),20 30 parts of ramulus mori,10 20 parts of bark of ash,Raw 10 40 parts of the Radix Astragali,10 20 parts of radix pseudostellariae,20 40 parts of the bighead atractylodes rhizome,20 40 parts of rhizoma atractylodis,10 20 parts of Poria cocos,20 40 parts of plantain seed,50 70 parts of smilax,20 40 parts of coix seed,5 20 parts of radix bupleuri,5 20 parts of rattletop,10 20 parts of Radix Angelicae Sinensis,10 20 parts of the root of herbaceous peony,10 20 parts of cassia twig,10 20 parts of golden cypress,15 30 parts of the root of bidentate achyranthes,10 20 parts of lycopodium calvatum,10 20 parts of the root of Chinese clematis,Play both sides of the street 10 20 parts,10 20 parts of reticulate millettia,15 30 parts of Chinese Fevervine Herb,10 20 parts of caulis lonicerae,15 25 parts of root of Chinese trichosanthes,5 15 parts of radix glycyrrhizae.The invention also discloses the preparation method of the Chinese medicine composition.The present composition have rise clear, drop is turbid, dispelling wind and eliminating dampness, gain qi and blood and other effects, can rapid recovery gouty joint pain, effectively reduce blood uric acid value, it is treatment gout good effect, uneasy to recur.

Description

A kind of Chinese medicine composition for gout and preparation method thereof
Technical field
The invention belongs to medicine field, and in particular to a kind of Chinese medicine composition for gout and preparation method thereof.
Background technology
One group of heterogeneity disease that blood uric acid caused by gout is due to purine metabolic disturbance and (or) uric acid excretion disorder increases Disease.Its clinical characters is hyperuricemia, gouty acute arthritis recurrent exerbation, tophaceous deposition, characteristic chronic joint Scorching and joint deformity, often involves kidney and causes arteriosclerotic kidney and kidney calculus urate to be formed.Patient is mostly more than 40 years old Male, women are more common in climacteric sequela.With the improvement of people's living standards, the incidence of gout caused by hyperuricemia Increasingly increase.Current global gout patient is up to 1.2 hundred million, and China gout patient is more than 40,000,000 people, and the incidence of disease is higher than World average level.Gout and its complication can reduce the quality of life of people, seriously endanger health of people, but do not have so far The preferably medicine for the treatment of gout.Colchicin, NSAIDs, glucocorticoid etc. are the treatments clinically commonly used at present The medicine of gout, curative effect is fine, but its serious side effect and adverse reaction, such as Nausea and vomiting, watery diarrhea, liver cell damage Wound, bone marrow suppression, alopecia and kidney failure etc., make clinical practice by a definite limitation.Chinese medicine and natural drug treatment pain in recent years Wind arthritis has the advantages such as curative for effect, safe and reliable, adverse reaction is small, is gradually paid attention to by medical field.
Gout category Chinese medical ' arthralgia syndrome ' category, and excessive uric acid then belongs to " wet turbid "；The traditional Chinese medical science think the pathogenesis of gout with Liver,spleen,kidney functional disturbance is closely related, its formed the main reason for be native endowment deficiency, ferritic is insufficiency of the spleen, the day after tomorrow addiction cream Fine strain of millet savoury, the with the passing of time impairment of the spleen, or old spleen renal dysfunction, and have with inducements such as diet, mood, overstrain, diseases caused by external factors cold-dampness, environment Close.Emphasize to start with from regulation liver,kidney,spleen function in treatment, advocate based on diagnosis and treatment, it then follows integral principle, carry out overall tune Reason.Compatibility application is particular about in Chinese medicine medication, can too many levels, Mutiple Targets treatment gout, it is small relative to Western medicine toxic side effect, have compared with Gao An Quan Xing.The present invention develops a kind of Chinese traditional medicine composition for gout after being analysed in depth for the pathogenesis of patient with gout Thing, at present, there is not yet relevant report.
(1) turtle shell, it is Trionychidae animal soft-shelled turtle Trionyx sinensis Wiegmann carapace.Record in《Chinese Pharmacopoeia》 Version in 2015：【Nature and flavor and channel tropism】It is salty, it is slightly cold.Return liver and kidney channel.【Function is with curing mainly】Nourishing and suppressing Yang, bring down a fever except steaming, softening hard masses dissipate Knot.For fever due to yin deficiency, hectic fever due to yin labor heat, hyperactivity of yang due to yin deficiency, have a dizzy spell, endogenous deficient wind, brothers' Chi is remorse, Amenorrhea , Disorder lumps in the abdomen, chronic malaria malaria It is female.
(2) oyster, it is long oyster Ostrea gigas Thimberg of Ostreidae animal, ostrea talienwhanensis Crosse Ostrea Talienwhanensis Crosse or Crassostrea rivularis Ostrearivularis Gould shell.Record in《Chinese Pharmacopoeia》 Version in 2015：【Nature and flavor and channel tropism】It is salty, it is slightly cold.Return liver, courage, kidney channel.【Function is with curing mainly】It is transquilization with heavy material, checking exuberance of yang tonifying yin, softening hard masses Dissipating bind.For insomnia of palpitating with fear, dizziness and tinnitus, scrofula addiction subcutaneous nodule , Disorder Jia Pi Boundless.Calcined oyster shell convergence is astringent or styptic treatment for spontaneous sweating, relieving haperacidity analgesic.For spontaneous perspiration Night sweat, emission and spermatorrhea, under uterine bleeding band, acid regurgitation of having a stomachache.
(3) mantis egg-case, it is Mantidae insect Chinese mantid Tenoderasinensis Saussure, maculated mantis Statili a MacwZafa (Thunberg) or hierodula patellifera patellifera (Serville) drying ootheca.Record in《Chinese Pharmacopoeia》 Version in 2015：【Nature and flavor and channel tropism】It is sweet, salty, put down.Return liver and kidney channel.【Function is with curing mainly】Astringent sperm contracting urine, tonify the kidney and support yang.For losing Smart involuntary emission, enuresis frequent micturition, urine gonorrhoea.
(4) radix stellariae dichotomae, it is pinkwort radix stellariae dichotomae Stellaria dichotoma L.var.lanceolata Bge. Dry root.Record in《Chinese Pharmacopoeia》Version in 2015：【Nature and flavor and channel tropism】It is sweet, it is slightly cold.Return liver, stomach.【Function is with curing mainly】 Clearind deficient heat, treating infantile malnutrition wide fever.For bright heat of shooting without hitting the target, hectic fever due to yin labor heat, children's infantile malnutrition due to digestive disturbances or intestinalparasites heat.
(5) red sage root, it is the labiate red sage root miltiorrhiza Bge. dry root and rhizome.Record in《Middle traditional Chinese medicines Allusion quotation》Version in 2015：【Nature and flavor and channel tropism】Hardship, it is slightly cold.The thoughts of returning home, Liver Channel.【Function is with curing mainly】Promoting blood circulation, it is inducing meastruation to relieve menalgia, clear away heart-fire Relieving restlessness, cool blood to disappear carbuncle.For chest impediment and cardialgia, gastral cavity abdomen hypochondriac pain , lumps in the chest and abdomen, hot numbness pain, dysphoria and insomnia, irregular menstruation, dysmenorrhoea Amenorrhea, sore swell and ache curative.
(6) Gorgon fruit, it is nymphaeaceae plant Gorgon euryale Euryale ferox Salisb. dry mature kernal.Record in《China Pharmacopeia》Version in 2015：【Nature and flavor and channel tropism】It is sweet, puckery, put down.Returns spleen, kidney channel.【Function is with curing mainly】Supplementing the kidney to control the nocturnal, tonifying spleen and stopping diarrhea, remove Wet stop-band.For emission and spermatorrhea, enuresis frequent micturition, insufficiency of the spleen chronic diarrhea, gonorrhoea, with.
(7) ramulus mori, it is moraceae plants mulberry Morus alba L. dry twig.Record in《Chinese Pharmacopoeia》Version in 2015： 【Nature and flavor and channel tropism】Slight bitter, put down.Return liver warp.【Function is with curing mainly】Wind-damp dispelling, sharp joint.For Bi condition, shoulder arm, joint acid Pain is numb.
(8) bark of ash, it is gentianaceae plant bark of ash Gentiana macrophylla Pall., gentiana straminea maxim Gentiana Straminea Maxim., gentiana crassicaulis Duthie Gentiana crassicaulis Duthie ex Burk. or radix gentiane dahuvicae Gentiana dahurica Fisch. dry root.Record in《Chinese Pharmacopoeia》Version in 2015：【Nature and flavor and channel tropism】It is pungent, bitter, It is flat.Return stomach, liver, gallbladder channel.【Function is with curing mainly】Wind-damp dispelling, clearing away damp-heat, stopping numbness pain, reducing the asthenic fever.For arthralgia pain due to rheumatism, apoplexy half body It is unsuccessful, muscle arteries and veins contraction, skeletal pain, jaundice with damp-heat pathogen, osteopyrexia and fever, infantile malnutrition generates heat.
(9) Radix Astragali, it is legume astragalus mongolicus Astragalus membranaceus (Fisch.) Bge.var.mongholicus (Bge.) Hsiao or Astragalus membranacus Astragalus membranaceus (Fisch.) Bge.'s Dry root.Record in《Chinese Pharmacopoeia》Version in 2015：【Nature and flavor and channel tropism】It is sweet, tepor.Return lung, the spleen channel.【Function is with curing mainly】Mend Gas lift sun, strengthening exterior and reducing sweat, inducing diuresis for removing edema, blood-nourishing of promoting the production of body fluid, the stagnant logical numbness of row, pus draining and toxin expelling, expelling pus and promoting granulation.For treatment deficiency of vital energy weak, food Few loose stool, the sinking of qi of middle-jiao, rush down prolapse of the anus for a long time, uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy oedema, Heat Diabetes, blood deficiency chlorosis, half body is not Then, numbness pain is numb, ulcer is difficult to burst, burst for a long time and does not holds back.
(10) radix pseudostellariae, it is pinkwort caryophyllaceous ginseng Pseudostellaria heterophylla (Miq.) Pax ex Paxet Hoffm. dried root.Record in《Chinese Pharmacopoeia》Version in 2015：【Nature and flavor and channel tropism】It is flat, sweet, slight bitter；Returns spleen, Lung channel.【Function is with curing mainly】Replenish qi to invigorate the spleen, it is promoting production of body fluid and nourishing the lung.It is tired for insufficiency of the spleen body, poor appetite, eak after being ill, deficiency of both vital energy and Yin, from Sweat is thirsty.
(11) bighead atractylodes rhizome, it is feverfew bighead atractylodes rhizome Atractylodes macrocephala Koidz. dry rhizome.Receive It is loaded in《Chinese Pharmacopoeia》Version in 2015：【Nature and flavor and channel tropism】Temperature, it is bitter, sweet；Returns spleen, stomach.【Function is with curing mainly】Strengthening the spleen and replenishing qi, Eliminate dampness and have diuretic effect, hidroschesis are antiabortive.For spleen eating less, abdominal distention diarrhea, phlegm retention anti-dazzle nervous, oedema, spontaneous perspiration, fetal irritability.
(12) rhizoma atractylodis, it is feverfew Atractylis lancea Atractylodes lancea (Thunb.) DC. or Atractylis chinensis Atractylodes chinensis (DC.) Koidz. dry rhizome.Record in《Chinese Pharmacopoeia》Version in 2015：【Nature and flavor with Channel tropism】It is pungent, bitter, temperature.Returns spleen, stomach, Liver Channel.【Function is with curing mainly】Eliminating dampness Jian spleens, expelling wind and clearing away cold, improving eyesight.For damp retention in middle-jiao, gastral cavity Distention and fullness in the abdomen, diarrhea, oedema, arthralgia pain due to rheumatism, anemofrigid cold, yctalopia, eyes dusk are puckery.
(13) Poria cocos, it is On Polyporaceae Poria cocos Poria cocos (Schw.) Wolf dry sclerotia.Record in《In State's pharmacopeia》Version in 2015：【Nature and flavor and channel tropism】It is flat, it is sweet, light；The thoughts of returning home, lung, spleen, kidney channel.【Function is with curing mainly】Clearing damp and promoting diuresis, it is good for Spleen calming heart.For oedema oliguria, phlegm retention anti-dazzle nervous, spleen eating less, loose stool diarrhea, confused and worried, insomnia of palpitating with fear.
(14) plantain seed, it is plantago plant Chinese herbaceous peony Plantago asiatica L or ordinary building Plantago Depressa Willd. dry mature seed.Record in《Chinese Pharmacopoeia》Version in 2015：【Nature and flavor and channel tropism】It is sweet, tremble with fear.Return Liver, kidney, lung, small intestinl channel.【Function is with curing mainly】Reducing fever and causing diuresis is treating stranguria, excreting dampness antidiarrheal, improving eyesight, eliminating the phlegm.For heat gonorrhea Where pains, oedema Turgor, summer heat damp diarrhea, red eye, swell pain, phlegm-heat cough.
(15) smilax, it is liliaceous plant smilacis glabra Smilax glabra Roxb. dry rhizome.Record in 《Chinese Pharmacopoeia》Version in 2015：【Nature and flavor and channel tropism】It is sweet, light, put down.Return liver, stomach.【Function is with curing mainly】Removing toxic substances, dehumidifying, tonneau Joint.For the limbs contraction caused by syphilis and mercury poisoning, arthralgia and myalgia；Damp and hot stranguria with turbid discharge, with, carbuncle swells, scrofula, mange.
(16) coix seed is grass Job's tears Coixlacryma-jobi L.var.mayuen (Roman.) Stapf Dry mature kernal.Record in《Chinese Pharmacopoeia》Version in 2015：【Nature and flavor and channel tropism】It is sweet, light, it is cool.Returns spleen, stomach, lung channel.【Work( Can be with curing mainly】Clearing damp and promoting diuresis, invigorating the spleen to arrest diarrhea, eliminating impediment, apocenosis, removing toxic substances dissipate, knot.For oedema, tinea pedis, difficult urination is insufficiency of the spleen to let out Rush down, arthritis with fixed pain caused by dampness contraction, lung carbuncle, acute appendicitis, wart, cancerous swelling.
(17) radix bupleuri, it is umbelliferae bupleurum Bupleurum chinense DC. or radix bupleuri scorzoneraefolii Bupleurum sc Orzonerifolium Willd. dry root.Record in《Chinese Pharmacopoeia》Version in 2015：【Nature and flavor and channel tropism】It is pungent, bitter, it is micro- It is cold.Return liver, courage, lung channel.【Function is with curing mainly】Evacuation is brought down a fever, soothing liver-qi stagnation, is risen and is lifted yang-energy.For cold, fever, fevers and chills alternate, Distending pain in the chest and hypochondrium, irregular menstruation, the prolapse of uterus, prolapse of the anus.
(18) rattletop, it is ranunculaceae plant C.heracleifolia C imic ifu g a heracleifolia Kom., Xingan Rattletop Cimicifuga dahurica (Turcz) Maxim or rattletop Cimicifuga foetida L. dry rhizome.Record In《Chinese Pharmacopoeia》Version in 2015：【Nature and flavor and channel tropism】】Pungent, micro-sweet, is slightly cold.Return lung, spleen, stomach, large intestine channel.【Function is with curing mainly】 Promoting eruption is delivered, it is clearing heat and detoxicating, rise and lift yang-energy.Spot is sent out for headache due to pathogenic wind-heat, dentalgia, aphtha, abscess of throat, measles without adequate eruption, sun poison, Prolapse of the anus, the prolapse of uterus.
(19) Radix Angelicae Sinensis, it is umbelliferae angelica Angelica sinensis (Oliv.) Diels dry root.Record in 《Chinese Pharmacopoeia》Version in 2015：【Nature and flavor and channel tropism】Sweet, acrid, warm.Return liver, the heart, the spleen channel.【Function is with curing mainly】Replenishing and activating blood, adjust Meridian and relieving pain, relax bowel.For blood deficiency chlorosis, dizziness palpitaition, irregular menstruation, closed dysmenorrhea, asthenia cold abdominalgia, arthralgia pain due to rheumatism, fall Flutter damage, ulcer sores, dry constipation of intestines.Prepared RADIX ANGELICAE SINENSIS with yellow rice wine invigorate blood circulation.For closed dysmenorrhea, arthralgia pain due to rheumatism, fall and flutter damage and put in order.
, (20) root of herbaceous peony, the dry root for being cohosh Chinese herbaceous peony medicine Paeonia lactiflora PalL.Record in《In State's pharmacopeia》Version in 2015：【Nature and flavor and channel tropism】Bitter, acid, is slightly cold.Return liver, the spleen channel.【Function is with curing mainly】Nourishing blood for regulating menstruation, hold back the moon and stop Sweat, soft liver analgesic, suppressing liver-YANG.For blood deficiency chlorosis, irregular menstruation, spontaneous perspiration, night sweat, hypochondriac pain, stomachache, four limbs contraction pain, headache Dizziness.
(21) cassia twig, it is canella Chinese cassia tree Cirmarnomumcassia Presl dry twig.Record in《China Pharmacopeia》Version in 2015：【Nature and flavor and channel tropism】Acrid, sweet, warm.The thoughts of returning home, lung, bladder warp.【Function is with curing mainly】Sweating expelling pathogenic factors from muscles and skin, temperature are stimulated the menstrual flow Arteries and veins, helps yang transforming qi, flat gas that spins.For anemofrigid cold, coldness and pain in the epigastrium, blood trembles with fear Amenorrhea, joint pain, phlegm and retained fluid, oedema, palpitaition, Run quickly globefish.
(22) golden cypress, it is rutaceae wampee Phellodendron chinense Schneid. dry bark. Record in《Chinese Pharmacopoeia》Version in 2015：【Nature and flavor and channel tropism】Hardship, tremble with fear.Return kidney, bladder warp.【Function is with curing mainly】Heat-clearing and damp-drying drug, Purging intense heat, except steaming, detoxification sore treatment.For damp-heat dysentery, yellow subcutaneous ulcer urine is red, and with lower pruritus vulvae, puckery pain of heat gonorrhea, tinea pedis Wei Cu, hectic fever due to yin labor is hot, Night sweat, seminal emission, sore swollen toxin, eczema wet sore.Stir-baked CORTEX PHELLODENDRI with salt solution nourishing Yin and falling fire.For fire excess from yin deficiency, night sweat hectic fever due to yin.
(23) root of bidentate achyranthes, it is amaranthaceous plant root of bidentate achyranthes Achyranthes bidentata B1. dry root.Record in《China Pharmacopeia》Version in 2015：【Nature and flavor and channel tropism】It is bitter, sweet, sour, put down；Return liver and kidney channel.【Function is with curing mainly】Dispelling stasis of blood and stimulating the menstrual flow, filling liver kidney, Strengthening the bones and muscles, inducing diuresis for treating strangurtia, ensuring proper downward flow of the blood.For Amenorrhea, dysmenorrhoea, soreness of waist and knee joint, muscles and bones is powerless, stranguria, oedema, headache, dizziness, Toothache, aphtha, spit blood, bleeding from five sense organs or subcutaneous tissue.
(24) lycopodium calvatum, it is lycopsid lycopod Lycopodium japonicum Thunb. drying herb.Record In《Chinese Pharmacopoeia》Version in 2015：【Nature and flavor and channel tropism】Slight bitter, pungent, temperature.Return liver, spleen, kidney channel.【Function is with curing mainly】Wind-dispelling removes It is wet, relaxing tendons and activating collaterals.For joint pain, joint stuffiness.
(25) root of Chinese clematis, it is cohosh root of Chinese clematis Clematis chinensis Osbeck, Clematis hexapetala Clematis hexapetala Pall. or northeast clematis Clematis manshurica Rupr. dry root and rhizome. Record in《Chinese Pharmacopoeia》Version in 2015：【Nature and flavor and channel tropism】It is pungent, salty, temperature；Return bladder warp.【Function is with curing mainly】Wind-damp dispelling, lead to Channels and collaterals.For arthralgia pain due to rheumatism, extremity numbness, muscle arteries and veins contraction, joint stuffiness.
(26) play both sides of the street, be Hamamelidaceae Plants Chinese sweet gum Liquidambar formosanaHance drying and ripening fruit Sequence.Record in《Chinese Pharmacopoeia》Version in 2015：【Nature and flavor and channel tropism】Hardship, put down.Return liver and kidney channel.【Function is with curing mainly】Dispelling, collateral-activating, Li Shui, stimulate the menstrual flow.For joint pain, numbness contracture, oedema turgor, breast is few, Amenorrhea.
(27) reticulate millettia, it is legume spatholobus suberectus Spatholobus suberectus Dunn drying rattan.Record In《Chinese Pharmacopoeia》Version in 2015：【Nature and flavor and channel tropism】It is bitter, sweet, temperature.Return liver and kidney channel.【Function is with curing mainly】Blood circulation promoting and enriching, menstruation regulating Analgesic, relaxing tendons and activating collaterals.For irregular menstruation, dysmenorrhoea, Amenorrhea, arthralgia pain due to rheumatism, paralysis and numbness, blood deficiency chlorosis.
(28) Chinese Fevervine Herb, it is the herb and root of madder wort Chinese Fevervine Herb.Record in《Dictionary of medicinal plant》：【Nature and flavor are with returning Through】Sweet acid, put down；The heart, liver, spleen, kidney channel.【Function is with curing mainly】Dispelling wind and eliminating dampness, promoting digestion and removing indigestion, removing toxicity for detumescence, promoting blood circulation and stopping pain.For Arthralgia pain due to rheumatism, dyspeptic abdominal distention, infantile malnutrition, diarrhoea, acute appendicitis.
(29) caulis lonicerae, it is caprifoliaceae plant honeysuckle Lonicera japoranica Thumb. drying stem branch.Record In《Chinese Pharmacopoeia》Version in 2015：【Nature and flavor and channel tropism】It is sweet, tremble with fear.Attach to the lung and stomach meridians.【Function is with curing mainly】It is clearing heat and detoxicating, Shu Fengtong Network.For warm disease heating, toxic-heat and blood stasis, carbuncle swells sore, beriberoid pyretic arthralgia, the red arsine heat pain in joint.
(30) root of Chinese trichosanthes, building is included for cucurbitaceous plant snakegourd Trichosanthes kirilowii Maxim. or bilateral Trichosanthes rosthornii Harms dry root.Record in《Chinese Pharmacopoeia》Version in 2015：【Nature and flavor and channel tropism】 Sweet, slight bitter, is slightly cold.Attach to the lung and stomach meridians.【Function is with curing mainly】Clearing heat-fire, promote the production of body fluid to quench thirst, detumescence and apocenosis.For pyreticosis polydipsia, lung Hot cough caused by dryness, Heat Diabetes, sore swollen toxin.
(31) radix glycyrrhizae, it is glycyrrhizic legume Glycyrrhiza uralensis Fisch., swollen fruit Radix Glycyrrhiza inflata Bat. or glycyrrhiza glabra Glycyrrhiza glabra L. dry root and rhizome.Record in 《Chinese Pharmacopoeia》Version in 2015：【Nature and flavor and channel tropism】It is sweet, put down.The thoughts of returning home, lung, spleen, stomach.【Function is with curing mainly】Invigorate the spleen and benefit qi, clearly Thermal detoxification, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription.For weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, coughing with a lot of sputum, gastral cavity Abdomen, four limbs contraction, carbuncle sore tumefacting virus, alleviate drug toxicity, strong.
The disclosure of background above technology contents is only used for inventive concept and the technical scheme that auxiliary understands the present invention, and it is not The prior art of present patent application is necessarily belonged to, shows the applying date of the above in present patent application in no tangible proof In the case of disclosed, above-mentioned background technology should not be taken to evaluate the novelty and creativeness of the application.
The content of the invention
The invention provides a kind of Chinese medicine composition for gout and preparation method thereof, to solve to exist in the prior art Treatment gout drug side-effect is big, liver kidney poisons big, bone marrow suppression, suppresses the problems such as central nervous system.The present invention's Chinese medicine composition have rise clear, drop is turbid, dispelling wind and eliminating dampness, qi and activate blood circulation and other effects, can effectively remove virulence factor, have significant Anti-inflammatory, analgesia, anti-trioxypurine effect and immunological enhancement, and toxic side effect is small, it is uneasy to recur after treatment.
To solve the above problems, the technical solution adopted by the present invention is as follows：
A kind of Chinese medicine composition for gout, include the raw material of following parts by weight：Turtle shell (system) 20-40 parts, oyster (forging) 15-25 parts, mantis egg-case 10-20 parts, radix stellariae dichotomae 10-20 parts, red sage root 18-30 parts, Gorgon fruit (stir-fry) 10-20 parts, ramulus mori 20-30 Part, bark of ash 10-20 parts, raw Radix Astragali 10-40 parts, radix pseudostellariae 10-20 parts, bighead atractylodes rhizome 20-40 parts, rhizoma atractylodis 20-40 parts, Poria cocos 10-20 Part, plantain seed 20-40 parts, smilax 50-70 parts, coix seed 20-40 parts, radix bupleuri 5-20 parts, rattletop 5-20 parts, Radix Angelicae Sinensis 10-20 Part, root of herbaceous peony 10-20 parts, cassia twig 10-20 parts, golden cypress 10-20 parts, root of bidentate achyranthes 15-30 parts, lycopodium calvatum 10-20 parts, root of Chinese clematis 10-20 Part, the 10-20 parts that play both sides of the street, reticulate millettia 10-20 parts, Chinese Fevervine Herb 15-30 parts, caulis lonicerae 10-20 parts, root of Chinese trichosanthes 15-25 parts, radix glycyrrhizae 5-15 parts.
The above-described Chinese medicine composition for gout, most preferably preferably include the raw material of following parts by weight：Turtle shell (system) 30 parts, 20 parts of oyster (forging), 15 parts of mantis egg-case, 16 parts of radix stellariae dichotomae, 22 parts of the red sage root, 15 parts of Gorgon fruit (stir-fry), 25 parts of ramulus mori, bark of ash 16 Part, raw 25 parts of the Radix Astragali, 15 parts of radix pseudostellariae, 30 parts of the bighead atractylodes rhizome, 30 parts of rhizoma atractylodis, 15 parts of Poria cocos, 30 parts of plantain seed, 60 parts of smilax, the heart of a lotus seed 30 parts of the seed of jog's tears, 12 parts of radix bupleuri, 13 parts of rattletop, 15 parts of Radix Angelicae Sinensis, 15 parts of the root of herbaceous peony, 15 parts of cassia twig, 15 parts of golden cypress, 22 parts of the root of bidentate achyranthes, stretch muscle Grass 16 parts, 15 parts of the root of Chinese clematis, play both sides of the street 15 parts, 15 parts of reticulate millettia, 22 parts of Chinese Fevervine Herb, 15 parts of caulis lonicerae, 20 parts of root of Chinese trichosanthes, radix glycyrrhizae 10 parts.
The above-described Chinese medicine composition for gout, pharmaceutically acceptable any oral formulations are prepared into, preferably Oral solid formulation is prepared into, is most preferably preferably prepared to capsule.
The method that the Chinese medicine composition for gout described in more than one is prepared into capsule, comprises the following steps：
S1. raw material is weighed by following parts by weight：Turtle shell (system) 20-40 parts, oyster (forge) 15-25 parts, mantis egg-case 10-20 Part, radix stellariae dichotomae 10-20 parts, red sage root 18-30 parts, Gorgon fruit (stir-fry) 10-20 parts, ramulus mori 20-30 parts, bark of ash 10-20 parts, the raw Radix Astragali 10-40 parts, radix pseudostellariae 10-20 parts, bighead atractylodes rhizome 20-40 parts, rhizoma atractylodis 20-40 parts, Poria cocos 10-20 parts, plantain seed 20-40 parts, native Fu Siberian cocklebur 50-70 parts, coix seed 20-40 parts, radix bupleuri 5-20 parts, rattletop 5-20 parts, Radix Angelicae Sinensis 10-20 parts, root of herbaceous peony 10-20 parts, cassia twig 10- 20 parts, golden cypress 10-20 parts, root of bidentate achyranthes 15-30 parts, lycopodium calvatum 10-20 parts, root of Chinese clematis 10-20 parts, play both sides of the street 10-20 parts, reticulate millettia 10-20 parts, Chinese Fevervine Herb 15-30 parts, caulis lonicerae 10-20 parts, root of Chinese trichosanthes 15-25 parts, radix glycyrrhizae 5-15 parts；
S2. load weighted medicinal material is taken, is added water to cook, is filtered, merging filtrate；
S3. step S2 filtrate is condensed into thick paste, dry, pulverize, get dry extract fine powder；
S4. take step S3 dry cream fine powder to add filler, lubricant, mix, load capsule, produce.
Further, the above-described Chinese medicine composition for gout is prepared into the method for capsule, step S2 institutes Decoction is stated first to add 5-8 times of water first to decoct 2-3h turtle shell, oyster, is filtered, filtrate is continued to employ, the dregs of a decoction again with remaining medicinal material (Chinese herbaceous peony Son is bound up with gauze) decoct 2 times together, for the first time plus 2-3h is boiled in 10-15 times of decocting, and for the second time plus 1-2h is boiled in 8-10 times of decocting； Filler described in step S4 is that the one or more in starch, microcrystalline cellulose and dextrin combine, the lubricant For the one or more combination in magnesium stearate, talcum powder and silica.
The above-described Chinese medicine composition for gout, the purposes in the medicine for gout is prepared.
Compared with prior art, beneficial effects of the present invention are as follows：
1. the present invention is according to traditional Chinese medicine theory, with reference to the dialectical therapy of modern Chinese medicine, prescription rigorous and scientific.Fang Zhongxuan With turtle shell, oyster, mantis egg-case, nourishing and suppressing Yang, tonify the liver and kidney；Radix stellariae dichotomae is clearing heat and detoxicating；The red sage root, Gorgon fruit, strengthen the spleen and stomach, promoting blood circulation Stagnation resolvation；Ramulus mori, bark of ash, lycopodium calvatum, caulis lonicerae, reticulate millettia, Chinese Fevervine Herb, the root of bidentate achyranthes, play both sides of the street, draw degrading the channel obstructed in body or The trunk of half obstruction, branch repair unobstructed, cooperation street cleaner's exclusion rubbish；The Radix Astragali, radix pseudostellariae, the bighead atractylodes rhizome, radix glycyrrhizae, Gu shield mechanism of qi, Protect the function of itself；Radix Angelicae Sinensis, the root of herbaceous peony, reticulate millettia, qi and activate blood circulation, supplement body substances；Rattletop, radix bupleuri, the bighead atractylodes rhizome, adjust body Function and metabolic operation function；Poria cocos, smilax, rhizoma atractylodis, coix seed, plantain seed, Chinese Fevervine Herb, discharging garbage from body, poison Thing deposits；Cassia twig, the root of Chinese clematis, play both sides of the street, wind-dispelling activates yang；Root of Chinese trichosanthes, lubrication protection passage；Caulis lonicerae, rattletop, radix glycyrrhizae, the root of bidentate achyranthes, Golden cypress, the protection of eliminating inflammation and expelling toxin, reinforcement to body；All medicines share gather altogether rise clear, drop is turbid, dispelling wind and eliminating dampness, the work(of qi and activate blood circulation, tool There are significant anti-inflammatory, analgesia, anti-trioxypurine effect and immunological enhancement, can rapid recovery gouty joint pain, effectively drop Low blood uric acid value, gout effective percentage is treated up to more than 96%.
2. the immunologic function of the invention by strengthening human body itself, the constitution and physiological function of shield human body in itself are cared for, leads to and adjusts The function of motion, already present virulence factor is thoroughly removed comprehensively and prevents its generation, gout is finally treated from root, curative effect is true Cut, toxic side effect is small, uneasy to recur.
Embodiment
With reference to specific embodiment, the invention will be further described, but does not limit the scope of the invention and apply Scope：
First, the Chinese medicine composition for gout is prepared into capsule
Embodiment 1
A kind of method that Chinese medicine composition for gout is prepared into capsule, comprises the following steps：
S1. raw material is weighed by following weight：Turtle shell (system) 4kg, oyster (forge) 2.5kg, mantis egg-case 2kg, radix stellariae dichotomae 2kg, Red sage root 3kg, Gorgon fruit (stir-fry) 2kg, ramulus mori 3kg, bark of ash 2kg, raw Radix Astragali 4kg, radix pseudostellariae 2kg, bighead atractylodes rhizome 4kg, rhizoma atractylodis 4kg, Poria cocos 2kg, plantain seed 4kg, smilax 7kg, coix seed 4kg, radix bupleuri 2kg, rattletop 2kg, Radix Angelicae Sinensis 2kg, root of herbaceous peony 2kg, cassia twig 2kg, Huang Cypress 2kg, root of bidentate achyranthes 3kg, lycopodium calvatum 2kg, root of Chinese clematis 2kg, the 2kg that plays both sides of the street, reticulate millettia 2kg, Chinese Fevervine Herb 3kg, caulis lonicerae 2kg, day Pollen 2.5kg, radix glycyrrhizae 1.5kg；
S2. take load weighted medicinal material, first add 8 times of water first to decoct 3h turtle shell, oyster, filter, filtrate continues to employ, the dregs of a decoction again with Remaining medicinal material (plantain seed binds up with gauze) is decocted 2 times together, and for the first time plus 3h is boiled in 15 times of decoctings, and for the second time plus 10 times of decoctings are boiled 2h, filtering, merging filtrate；
S3. step S2 filtrate is condensed into thick paste, dry, pulverize, get dry extract fine powder；
S4. take step S3 dry cream fine powder to add starch, microcrystalline cellulose and magnesium stearate, mix, load capsule, i.e., .
Embodiment 2
A kind of method that Chinese medicine composition for gout is prepared into capsule, comprises the following steps：
S1. raw material is weighed by following weight：Turtle shell (system) 2kg, oyster (forge) 1.5kg, mantis egg-case 1kg, radix stellariae dichotomae 1kg, Red sage root 1.8kg, Gorgon fruit (stir-fry) 1kg, ramulus mori 2kg, bark of ash 1kg, raw Radix Astragali 1kg, radix pseudostellariae 1kg, bighead atractylodes rhizome 2kg, rhizoma atractylodis 2kg, Fu Siberian cocklebur 1kg, plantain seed 2kg, smilax 5kg, coix seed 2kg, radix bupleuri 0.5kg, rattletop 0.5kg, Radix Angelicae Sinensis 1kg, root of herbaceous peony 1kg, cassia twig 1kg, golden cypress 1kg, root of bidentate achyranthes 1.5kg, lycopodium calvatum 1kg, root of Chinese clematis 1kg, the 1kg that plays both sides of the street, reticulate millettia 1kg, Chinese Fevervine Herb 1.5kg, bear Winter rattan 1kg, root of Chinese trichosanthes 1.5kg, radix glycyrrhizae 0.5kg；
S2. take load weighted medicinal material, first add 5 times of water first to decoct 2h turtle shell, oyster, filter, filtrate continues to employ, the dregs of a decoction again with Remaining medicinal material (plantain seed binds up with gauze) is decocted 2 times together, and for the first time plus 2h is boiled in 10 times of decoctings, and for the second time plus 8 times of decoctings are boiled 1h, filtering, merging filtrate；
S3. step S2 filtrate is condensed into thick paste, dry, pulverize, get dry extract fine powder；
S4. take step S3 dry cream fine powder to add microcrystalline cellulose, dextrin and magnesium stearate, mix, load capsule, i.e., .
Embodiment 3
A kind of method that Chinese medicine composition for gout is prepared into capsule, comprises the following steps：
S1. raw material is weighed by following weight：Turtle shell (system) 3kg, oyster (forge) 2kg, mantis egg-case 1.5kg, radix stellariae dichotomae 1.5kg, red sage root 2.5kg, Gorgon fruit (stir-fry) 1.5kg, ramulus mori 2.5kg, bark of ash 1.5kg, raw Radix Astragali 2kg, radix pseudostellariae 1.5kg, the bighead atractylodes rhizome 2.5kg, rhizoma atractylodis 2.5kg, Poria cocos 1.2kg, plantain seed 2.5kg, smilax 5.5kg, coix seed 2.5kg, radix bupleuri 1kg, rattletop 1kg, Radix Angelicae Sinensis 1.5kg, root of herbaceous peony 1.5kg, cassia twig 1.5kg, golden cypress 1.5kg, root of bidentate achyranthes 2kg, lycopodium calvatum 1.5kg, root of Chinese clematis 1.5kg, Play both sides of the street 1.5kg, reticulate millettia 1.2kg, Chinese Fevervine Herb 2kg, caulis lonicerae 1.2kg, root of Chinese trichosanthes 2kg, radix glycyrrhizae 1kg；
S2. load weighted medicinal material is taken, first adds 7 times of water first to decoct 2.5h turtle shell, oyster, is filtered, filtrate is continued to employ, and the dregs of a decoction are again Decocted 2 times with together with remaining medicinal material (plantain seed binds up with gauze), for the first time plus 2.5h is boiled in 12 times of decoctings, second plus 9 times of water Decoct 1.5h, filtering, merging filtrate；
S3. step S2 filtrate is condensed into thick paste, dry, pulverize, get dry extract fine powder；
S4. take step S3 dry cream fine powder to add starch, talcum powder and silica, mix, load capsule, produce.
2nd, clinical practice is tested
1. case selection standard
Reference《Chinese gout clinical diagnosis and treatment guide in 2010》、《Chinese medical disease Standardization of diagnosis and curative effect》Make a definite diagnosis.
2. therapeutic scheme
130 patient with gout for meeting above-mentioned standard (be male, the course of disease -10 years 3 months) are randomly divided into embodiment Group and positive controls, every group 65.
Embodiment group：Give the sample of the oral embodiment of the present invention 3, one time 4, three times a day.The course for the treatment of：Medication 4 weeks.
Control group：Oral commercially available colchicines tablets, oral 1 first, 1 is taken every 1h, diarrhoea is withdrawn, and is no more than daily 6mg；Oral 100mg of Allopurinol Tablets after 1~2d remissions, three times a day.The course for the treatment of：Medication 4 weeks.
3. observation index
(1) clinical symptoms index and method：1. pain：Without pain, 0 point；Mild pain, does not influence work, and l divides；Pain It is heavier, work, rest it is impacted, 2 points；It is in great pain, have a strong impact on rest, work, 3 points.2. swelling：Pneumonedema, 0 point；Slightly Swelling：Dermatoglyph shoals, and joint bone mark is still obvious, 1 point；Moderate swelling：Swelling is obvious, and dermatoglyph disappears, and joint bone mark is failed to understand It is aobvious, 2 points；Severe swelling：Swelling is serious, skin-tightening, joint bone marks obliterated, 3 points.
(2) lab index：The indexs such as blood uric acid, blood routine, routine urinalysis, renal function, liver function, stool routine examination.
4. criterion of therapeutical effect
(1) fully recover：Joint congestion and swelling pain disappears, and joint function recovery is normal, and blood uric acid is down to normal range (NR)；
(2) it is effective：Joint congestion and swelling pain substantially mitigates, and function of joint is normal, and blood uric acid is close to normal level；
(3) effectively：Joint congestion and swelling pain is alleviated, and blood uric acid value declines, but not up to range of normal value；
(4) it is invalid：Joint congestion and swelling pain symptom does not improve, and joint motion is limited, and blood uric acid value does not decline or declined not clear It is aobvious
5. result
(1) clinical efficacy
During experiment, there is gastrointestinal reaction (such as Nausea and vomiting, abdomen in none patient in the case of embodiment group Rush down), the adverse reaction such as fash, and there are 48 patients different degrees of gastrointestinal reactions occur in control group and (such as nausea, vomit Tell, suffer from diarrhoea), the adverse reaction such as fash, illustrate that Product Safety of the present invention is preferable.After treating 4 weeks, two groups of patient's total effectses ratios Relatively there is significant difference, display embodiment group total effectses are better than control group, illustrate that product curative effect of the present invention is preferable.It is shown in Table 1.
The clinical efficacy result of table 1
Note：Two groups of curative effects compare after treating 4 weeks,*P ＜ 0.05
(2) clinical indexes compare
Before treatment, the not statistically significant (P of comparing difference between blood uric acid, arthralgia degree, two groups of Articular swelling> 0.05)；After treatment, two groups of patient's blood uric acids, arthralgia degree, Articular swelling substantially change with itself more having before treatment Kind, indices itself more have significant difference (P before and after treatment<0.05), embodiment group reduces blood uric acid, alleviates joint Pain degree and Articular swelling more have significant difference (P with control group<0.05), show embodiment group reduce blood uric acid, Alleviate arthralgia degree and Articular swelling is superior to control group.It is shown in Table 2.
2 pretherapy and post-treatment blood uric acid of table, arthralgia, arthroncus situation compare (N=65)
Note：Two groups of more equal, P ＞ 0.05 before treatment；This group is relatively more equal before and after treatment, * P ＜ 0.05；With compareing after treatment Group compares,△P ＜ 0.05
It is typical example below：
Wu, man, 46 years old, suffers from gout 3 years, night often wakes up with a start because of articulationes metatarsophalangeae severe pain, in great pain, surrounding tissue There is phenomena such as red, swollen, hot, pain, through examination in hospital, blood uric acid 8.75mg/dl.Take 3 sample of the embodiment of the present invention 2 weeks Afterwards, red, swollen, hot, pain symptoms mitigate, then after continuously taking 2 weeks, red, swollen, hot, pain symptoms are disappeared, and after testing, blood uric acid is reduced to 5.68mg/dl.Continuous check is recurred for 2 years without discovery.
The specific implementation of the invention is not to be limited to these illustrations for above content, is led for technology belonging to the present invention For the those of ordinary skill in domain, without departing from the inventive concept of the premise, some simple deduction or replace can also be made, The scope of patent protection that the present invention is determined by the claims submitted should be all considered as belonging to.

Claims (10)

1. a kind of Chinese medicine composition for gout, it is characterised in that include the raw material of following parts by weight：Turtle shell (system) 20-40 Part, oyster (forge) 15-25 parts, mantis egg-case 10-20 parts, radix stellariae dichotomae 10-20 parts, red sage root 18-30 parts, Gorgon fruit (stir-fry) 10-20 parts, mulberry Branch 20-30 parts, bark of ash 10-20 parts, raw Radix Astragali 10-40 parts, radix pseudostellariae 10-20 parts, bighead atractylodes rhizome 20-40 parts, rhizoma atractylodis 20-40 parts, Fu Siberian cocklebur 10-20 parts, plantain seed 20-40 parts, smilax 50-70 parts, coix seed 20-40 parts, radix bupleuri 5-20 parts, rattletop 5-20 parts, when Return 10-20 parts, root of herbaceous peony 10-20 parts, cassia twig 10-20 parts, golden cypress 10-20 parts, root of bidentate achyranthes 15-30 parts, lycopodium calvatum 10-20 parts, Wheeling Celestial 10-20 parts, the 10-20 parts that play both sides of the street, reticulate millettia 10-20 parts, Chinese Fevervine Herb 15-30 parts, caulis lonicerae 10-20 parts, root of Chinese trichosanthes 15-25 Part, radix glycyrrhizae 5-15 parts.
2. the Chinese medicine composition according to claim 1 for gout, it is characterised in that include the original of following parts by weight Material：30 parts of turtle shell (system), 20 parts of oyster (forging), 15 parts of mantis egg-case, 16 parts of radix stellariae dichotomae, 22 parts of the red sage root, 15 parts of Gorgon fruit (stir-fry), ramulus mori 25 parts, 16 parts of bark of ash, raw 25 parts of the Radix Astragali, 15 parts of radix pseudostellariae, 30 parts of the bighead atractylodes rhizome, 30 parts of rhizoma atractylodis, 15 parts of Poria cocos, 30 parts of plantain seed, soil 60 parts of Poria cocos, 30 parts of coix seed, 12 parts of radix bupleuri, 13 parts of rattletop, 15 parts of Radix Angelicae Sinensis, 15 parts of the root of herbaceous peony, 15 parts of cassia twig, 15 parts of golden cypress, ox 22 parts of knee, 16 parts of lycopodium calvatum, 15 parts of the root of Chinese clematis, play both sides of the street 15 parts, 15 parts of reticulate millettia, 22 parts of Chinese Fevervine Herb, 15 parts of caulis lonicerae, smallpox 20 parts of powder, 10 parts of radix glycyrrhizae.
3. the Chinese medicine composition according to claim 1 or 2 for gout, it is characterised in that the Chinese medicine composition system It is standby into pharmaceutically acceptable any oral formulations.
4. the Chinese medicine composition according to claim 3 for gout, it is characterised in that the Chinese medicine composition is prepared into Oral solid formulation.
5. the Chinese medicine composition according to claim 4 for gout, it is characterised in that the Chinese medicine composition is prepared into Capsule.
6. a kind of method that Chinese medicine composition for gout according to claim 5 is prepared into capsule, its feature It is, comprises the following steps：
S1. raw material is weighed by following parts by weight：Turtle shell (system) 20-40 parts, oyster (forge) 15-25 parts, mantis egg-case 10-20 parts, silver Radix bupleuri 10-20 parts, red sage root 18-30 parts, Gorgon fruit (stir-fry) 10-20 parts, ramulus mori 20-30 parts, bark of ash 10-20 parts, raw Radix Astragali 10-40 Part, radix pseudostellariae 10-20 parts, bighead atractylodes rhizome 20-40 parts, rhizoma atractylodis 20-40 parts, Poria cocos 10-20 parts, plantain seed 20-40 parts, smilax 50- 70 parts, coix seed 20-40 parts, radix bupleuri 5-20 parts, rattletop 5-20 parts, Radix Angelicae Sinensis 10-20 parts, root of herbaceous peony 10-20 parts, cassia twig 10-20 parts, Golden cypress 10-20 parts, root of bidentate achyranthes 15-30 parts, lycopodium calvatum 10-20 parts, root of Chinese clematis 10-20 parts, the 10-20 parts that play both sides of the street, reticulate millettia 10-20 Part, Chinese Fevervine Herb 15-30 parts, caulis lonicerae 10-20 parts, root of Chinese trichosanthes 15-25 parts, radix glycyrrhizae 5-15 parts；
S2. load weighted medicinal material is taken, is added water to cook, is filtered, merging filtrate；
S3. step S2 filtrate is condensed into thick paste, dry, pulverize, get dry extract fine powder；
S4. take step S3 dry cream fine powder to add filler, lubricant, mix, load capsule, produce.
7. the method that the Chinese medicine composition according to claim 6 for gout is prepared into capsule, it is characterised in that step Decoct first to add 5-8 times of water first to decoct 2-3h turtle shell, oyster, filter described in rapid S2, filtrate is continued to employ, the dregs of a decoction again with remaining medicinal material (plantain seed binds up with gauze) is decocted 2 times together, and for the first time plus 2-3h is boiled in 10-15 times of decocting, and for the second time plus 8-10 times of decocting is boiled 1-2h。
8. the method that the Chinese medicine composition according to claim 6 for gout is prepared into capsule, it is characterised in that step Filler described in rapid S4 is one or more kinds of combinations in starch, microcrystalline cellulose and dextrin.
9. the method that the Chinese medicine composition according to claim 6 for gout is prepared into capsule, it is characterised in that step The lubricant described in rapid S4 is one or more kinds of combinations in magnesium stearate, talcum powder and silica.
10. it is used for the Chinese medicine composition of gout as claimed in claim 1 or 2, it is characterised in that said composition is used in preparation Purposes in the medicine of gout.
CN201711046475.4A 2017-10-31 2017-10-31 A kind of Chinese medicine composition for gout and preparation method thereof Pending CN107715014A (en)

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