CN103611050B - A pharmaceutical composition for intestinal tract cleaning - Google Patents

A pharmaceutical composition for intestinal tract cleaning Download PDF

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Publication number
CN103611050B
CN103611050B CN201310600879.9A CN201310600879A CN103611050B CN 103611050 B CN103611050 B CN 103611050B CN 201310600879 A CN201310600879 A CN 201310600879A CN 103611050 B CN103611050 B CN 103611050B
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parts
intestinal tract
radix
pharmaceutical composition
tract cleaning
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CN201310600879.9A
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CN103611050A (en
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张秀美
姜晓丽
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Abstract

The invention discloses a pharmaceutical composition for intestinal tract cleaning, for Semen Pharbitidis, Cortex Sapii Radicis, Rhizoma Iridis Japonicae, Semen Abutili, Fructus Cannabis, Semen Pruni, Poria, Herba Sedi, the Radix Linderae, Rhizoma Cyperi, the Radix Aucklandiae, Muscovitum, Fructus Amomi, Radix Codonopsis, Folium Et Cacumen Murrayae, Radix Glycyrrhizae medicine forms, the present invention is according to motherland's medical science and modern theory of integrated Chinese and western medicine, science selects medicine, each herbal medicine gets its length altogether, combined effect, form a unitary pharmaceutical composition coordinated, reach the object of intestinal tract cleaning, prevent high damage of letting out body simultaneously, alleviate stimulation and the untoward reaction of human body, clinical satisfied for intestinal cleaning effect, intestinal tract cleaning patient has good toleration, higher Clinical practice is had to be worth.

Description

A pharmaceutical composition for intestinal tract cleaning
Technical field
The present invention relates to a pharmaceutical composition for intestinal tract cleaning.
Background technology
Bowel preparation is clinical conventional medical skill means, the carrying out of abdominal operation, fibercolonscopy, plain abdominal radiograph, cholecystography, pyelography etc. treatment or diagnosis, first must carry out intestinal tract cleaning, feces residue and gas in intestinal are reduced to lowest range, and whether successfully bowel preparation meets the requirements is some clinical examinations, treatment one of key factor.
Current clinical conventional bowel preparation method mainly contains cleaning enema and oral drugs katharsis etc., and cleaning enema pours into liquid by anus per rectum, the object reaching softening excrement block, stimulate enterokinesia, promote defecation, intestinal tract cleaning; Oral drugs katharsis use intestinal tract cleaning oral drugs comprise Chinese medicine Folium Sennae, zest holds concurrently emollient laxative Oleum Ricini, bulk-forming catharsis medicine magnesium sulfate, mannitol, Glycerin Fructose, Polyethylene Glycol etc.The equal Shortcomings part of above-mentioned cleansing enema, medicine, such as, retain water quantities in cleaning enema enteric cavity limited, intestinal tract cleaning is only limitted to intestinal far-end, clean thorough, and easily causes the hyperemia of patient's intestinal mucosa, intestinal mucosa injury.The cathartics such as simple oral Folium Sennae, Oleum Ricini, magnesium sulfate, patient is concurrent to feel sick, the uncomfortable person such as stomachache, abdominal distention comparatively generally, some patients can not tolerate.The present invention's pharmaceutical composition for intestinal tract cleaning, according to motherland's medical science and modern theory of integrated Chinese and western medicine, science selects medicine, and clinical have good toleration for intestinal tract cleaning patient, and intestinal cleaning effect is satisfied.
Summary of the invention
The object of the invention is the pharmaceutical composition providing for intestinal tract cleaning.
In order to realize foregoing invention object, the present invention make this pharmaceutical composition effective ingredient raw material composition and weight proportion be: Semen Pharbitidis 4 parts, Cortex Sapii Radicis 4 parts, Rhizoma Iridis Japonicae 5 parts, Semen Abutili 4 parts, Fructus Cannabis 5 parts, Semen Pruni 5 parts, 4 parts, Poria, Herba Sedi 4 parts, the Radix Linderae 4 parts, Rhizoma Cyperi 4 parts, the Radix Aucklandiae 3 parts, 3 parts, Muscovitum, Fructus Amomi 3 parts, Radix Codonopsis 4 parts, Folium Et Cacumen Murrayae 4 parts, 4 parts, Radix Glycyrrhizae.
The present invention's pharmaceutical composition for intestinal tract cleaning, combines according to motherland's medical science and modern theory of integrated Chinese and western medicine.Wherein, Semen Pharbitidis is the dry mature seed of convolvulaceous plant pharbitis nilChoisy or Pharbitis purpurea; Bitter in the mouth, cold in nature, return lung, kidney, large intestine channel, the relieving constipation of function removing water retention by purgation.Cortex Sapii Radicis is the root bark removing cork or the peel of stem of euphorbia plant Cortex Sapii Radicis; Bitter in the mouth, slightly warm in nature, return large intestine channel, stomach warp, function removing water retention by purgation, dispersing swelling and dissipating binds.Rhizoma Iridis Japonicae is the rhizome of irides Herba Iridis japonicae; Bitter in the mouth, cold in nature, function helps digestion, relieving constipation, diuretic, invigorate blood circulation, pain relieving.Semen Abutili is the seed of Malvaceae plant Semen Abutili; Sweet in the mouth, cold in nature, return intestine and small intestine through, urinary bladder channel, function diuretic, laxation.Fructus Cannabis is the dry mature fruit of moraceae plants Fructus Cannabis; Sweet in the mouth, property are flat, and return spleen channel, stomach, large intestine channel, function moisturizes laxation, loosening bowel to relieve constipation.Semen Pruni is the dry mature seed of rosaceous plant Prunus humilis, strongly fragrant Lee or Prunus pedunculata Maxim.; Acrid in the mouth, hardship, sweet, property is put down, and enter large intestine channel, small intestinal, spleen channel, function moisturizes laxation, the therapeutic method to keep the adverse QI flowing downwards, diuretic, loosening bowel to relieve constipation.Poria is the dry sclerotia of On Polyporaceae Poria; Sweet in the mouth, light, property is put down, GUIXIN warp, lung, spleen, kidney channel, function promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.Herba Sedi is the dry herb of crassulaceae plants Herba Sedi; Sweet in the mouth, light, cool in nature, return Liver Channel, gallbladder, small intestine meridian, function eliminating damp-heat, removing toxic substances.Muscovitum is silicates mineral white Muscovitum; Sweet in the mouth, warm in nature, enter lung meridian, spleen, urinary bladder channel, function improving inspiration by invigorating kidney-QI pendant expectorant, continuous exhausted invigorating middle warmer, treats five kinds of strain and seven kinds of impairment.Fructus Amomi is the dry mature fruit of zingiberaceous plant Fructus Amomi, green shell sand or SEMEN AMOMI LONGILIGULA; Acrid in the mouth, warm in nature, return spleen channel, stomach, kidney channel, function removing dampness is whetted the appetite, warming spleen and stopping diarrha, tune stomach of being amusing.Folium Et Cacumen Murrayae is dried leaves and the band leaf twig of rutaceae Folium Et Cacumen Murrayae and Murraya paniculata (L.) Jack.; Acrid in the mouth, micro-hardship, warm in nature, GUIXIN warp, liver, lung meridian, function promoting the circulation of QI to relieve pain, promoting blood circulation to remove blood stasis.The dry root that Radix Codonopsis is Campanulaceae Radix Codonopsis, element spends Radix Codonopsis or radix codonpsis tangshen; Sweet in the mouth, property are flat, return spleen channel, lung meridian, function invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.The Radix Linderae is the dried root of the canella Radix Linderae; Acrid in the mouth, warm in nature, return lung, spleen, kidney, urinary bladder channel, function promoting the circulation of QI to relieve pain, taste vigour can be managed, pleasant, dissipating depression of QI, cold expelling, pain relieving.Rhizoma Cyperi is the dry rhizome of sedge dried tuber; Acrid in the mouth, sweet, property is put down, and enters liver, tri-jiao channel, function regulating QI to relieve pain.The Radix Aucklandiae is the dry root of the feverfew Radix Aucklandiae; Acrid in the mouth, hardship, warm in nature, return spleen, stomach, liver, large intestine channel, effect fragrance row is loose, can rise and can fall, promoting the circulation of QI to relieve pain, intestinal stasis relieving in tune.Radix Glycyrrhizae is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L.; Sweet in the mouth, property is put down, and enters spleen, stomach, lung meridian, function relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong, has and adjusts benefit effect.
The present invention's pharmaceutical composition for intestinal tract cleaning, Semen Pharbitidis, Cortex Sapii Radicis, Rhizoma Iridis Japonicae, Semen Abutili are purgatives medicine, play removing water retention by purgation, the stagnant defecating feces excretion of row; Fructus Cannabis, Semen Pruni are laxative drug, rise and moisturize laxation, functions of loosening bowel relieving constipation; Poria, Herba Sedi eliminating damp-heat, promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming; Muscovitum, Fructus Amomi, Radix Codonopsis removing dampness appetizing, tune stomach of being amusing, invigorating the spleen and replenishing QI, spleen invigorating lung benefiting, settling five organs, play prevent high let out cause dysfunction of spleen and stomach, recover action of enterogastric function; The Radix Linderae, Rhizoma Cyperi, the Radix Aucklandiae, Folium Et Cacumen Murrayae fragrance row fall apart, promoting blood circulation to remove blood stasis, play cold expelling, promoting the circulation of QI to relieve pain, regulating QI to relieve pain effect and the effect of protection gastrointestinal tract; Radix Glycyrrhizae makes medicine for full side, plays and middle emergency, all medicines of coordinating, cushion toxicity, strong effect.
The present invention's pharmaceutical composition for intestinal tract cleaning, Semen Pharbitidis, Cortex Sapii Radicis, Rhizoma Iridis Japonicae, Semen Abutili, Fructus Cannabis, Semen Pruni, above-mentioned a few herbal medicine shares, and under rushing down, relaxing the bowels with lubricant drugs lifts altogether, can cause fast and let out after oral, reaches cleaning intestinal object rapidly.All the other each taste medicines 5 to coordinate mutually, alleviate high stimulation of letting out body, high letting out and not being harmful to the health, and such as " medicineization justice " says that " Fructus Amomi, pungent loose hardship is fallen, and abnormal smells from the patient is all thick.Main eliminating stagnation intestinal stasis relieving, the circulation of qi promoting therapeutic method to keep the adverse QI flowing downwards, gets its fragrance energy and the five internal organs "; Folium Et Cacumen Murrayae circulation of qi promoting, invigorate blood circulation, dissipating blood stasis; Muscovitum nature and flavor are sweet, warm, and high to let out then the intestines and stomach all empty, and Gan Wen is enough to Hui Qixu; Herba Sedi eliminating damp-heat; The nourishing the stomach of Radix Glycyrrhizae profit kidney, all medicines of coordinating again; Muscovitum, Folium Et Cacumen Murrayae, Fructus Amomi, Herba Sedi, Radix Glycyrrhizae share, be amusing, nourishing the stomach, dampness removing, kidney tonifying, reason vigour, dispelling stagnant Qi, peace and the five internal organs.Such as " book on Chinese herbal medicine justice " thinks that " gas in strong fortune, this is very mutually not far away with Radix Ginseng for Radix Codonopsis power energy spleen reinforcing nourishing the stomach, the lung moistening and production of body fluid promoting.Its outstanding valuable person, then spleen invigorating fortune and not dry, grow stomach-Yin and not wetting, lung moistening and do not violate cold and cool, nourishes blood and partially do not grow greasy, inspiring clear sun, gas in vibration and without just dry fraud "; The compatibility such as Poria and Radix Codonopsis, invigorating middle warmer, spleen invigorating, QI invigorating, spleen reinforcing nourishing the stomach; Radix Linderae function of spleen and stomach regulating, invigorating the spleen and benefiting QI, to recover gastrointestinal function, Radix Codonopsis, the Radix Linderae share the transporting helping spleen, prevent high letting out from causing insufficiency of the spleen dysfunction of the spleen in transportation and transformation.Such as Poria, Radix Glycyrrhizae mutual reinforcement between, beneficial body fluid and and defend, avoid coldly hasty and carelessly completing agent impairing the spleen and stomach.Such as, in Rhizoma Cyperi blood circulation of qi promoting, in Radix Linderae gas and blood, Folium Et Cacumen Murrayae fragrance row is loose, Rhizoma Cyperi, the Radix Linderae, Folium Et Cacumen Murrayae leave altogether the stagnation of QI, except the effect of distension, pain relieving and the effect of protection gastrointestinal tract; The Radix Aucklandiae and the Radix Linderae all can promoting the circulation of QI to relieve pain, and mutual reinforcement between is use, and Radix Aucklandiae circulation of qi promoting power is good, and the Radix Linderae is regulated the flow of vital energy cold expelling, Radix Glycyrrhizae relieving spasm to stop pain, correct highly to let out the severe abdominal cramps caused.Radix Glycyrrhizae and middle emergency, all medicines of coordinating.Each herbal medicine gets its length, combined effect altogether, forms a unitary pharmaceutical composition coordinated, reaches the object of intestinal tract cleaning, alleviate stimulation and the untoward reaction of human body, protecting the spleen and stomach simultaneously, prevent high damage of letting out body.
The present invention's pharmaceutical composition for intestinal tract cleaning, its preparation method is, Semen Pharbitidis, Cortex Sapii Radicis, Rhizoma Iridis Japonicae, Semen Abutili, Fructus Cannabis, Semen Pruni, Poria, Herba Sedi, the Radix Linderae, Rhizoma Cyperi, the Radix Aucklandiae, Muscovitum, Fructus Amomi, Radix Codonopsis, Folium Et Cacumen Murrayae, Radix Glycyrrhizae powder are broken into coarse powder, extract ingredient, percolation can be used to extract ingredient, infusion process can be used to extract ingredient, decocting method can be used to extract ingredient, supercritical fluid extraction ingredient can be used, other suitable methods also can be used to extract ingredient.First the specific embodiment of the invention uses percolation to extract ingredient and makes solution.
Preparation method is:
Semen Pharbitidis, Cortex Sapii Radicis, Rhizoma Iridis Japonicae, Semen Abutili, Fructus Cannabis, Semen Pruni, Poria, Herba Sedi, the Radix Linderae, Rhizoma Cyperi, the Radix Aucklandiae, Muscovitum, Fructus Amomi, Radix Codonopsis, Folium Et Cacumen Murrayae, Radix Glycyrrhizae powder in formula are broken into coarse powder, medicated powder is added appropriate amount of purified water, make medicated powder fully uniform wet and expand after, even loading percolator, adds appropriate amount of purified water dipping, percolation, collects liquid of filtering, squeezing medicinal residues, pressed liquor and percolate merge, and filter, and add pure water to specified volume.
The usage of pharmaceutical composition that the present invention is used for intestinal tract cleaning is oral administration, need to carry out intestinal tract cleaning treatment or diagnose first 6 hours oral.
Invention embodiment
Medicine is prepared: Semen Pharbitidis 4 kilograms, Cortex Sapii Radicis 4 kilograms, Rhizoma Iridis Japonicae 5 kilograms, Semen Abutili 4 kilograms, Fructus Cannabis 5 kilograms, Semen Pruni 5 kilograms, 4 kilograms, Poria, Herba Sedi 4 kilograms, the Radix Linderae 4 kilograms, Rhizoma Cyperi 4 kilograms, the Radix Aucklandiae 3 kilograms, 3 kilograms, Muscovitum, Fructus Amomi 3 kilograms, Radix Codonopsis 4 kilograms, Folium Et Cacumen Murrayae 4 kilograms, 4 kilograms, Radix Glycyrrhizae by following medicament composing prescription consumption.
Pulverizing medicinal materials in above-mentioned formula is become coarse powder, medicated powder is added appropriate amount of purified water, make medicated powder fully uniform wet and expand after, evenly load percolator, add appropriate amount of purified water dipping, percolation, collect liquid of filtering, squeezing medicinal residues, pressed liquor and percolate merge, and filter, and add pure water to specified volume.Medication amount in above-mentioned formula prepares medicinal liquid 60,000 ml altogether.
Needs of patients carries out the treatment of intestinal tract cleaning or diagnoses first 6 hours oral 100ml to 150ml.
The pharmaceutical composition for intestinal tract cleaning of the present invention is illustrated, for the action effect of intestinal tract cleaning below by way of practical example.
One, case selection and drug use method
Prepare patient 52 example of row colonoscopy, 18 ~ 51 years old age, man 29 example, female 23 example.
The last late fasting of patient, with at work up first 6 hours morning next day, give the administering medicine liquid made by embodiment of the present invention, dosage gave 100ml to 150ml by weight in patients difference, disposable oral complete.
Two, therapeutic evaluation
Intestinal tract cleaning degree classification: I level--intestinal cleaning is satisfied, and gut mucosa display is clear; II level--have a small amount of excrement matter or liquid dung in enteric cavity, after rinsing and attracting, mucosal surface can show clear; III level--have more mushy stool in enteric cavity, after rinsing, mucosal surface is still unclear.
Curative effect is added up: I, II level is that intestinal tract cleaning is effective, and III level is that intestinal tract cleaning is invalid.
The observation of untoward reaction: the untoward reaction such as Nausea and vomiting, abdominal distention stomachache that record patient occurs in row INTESTINAL CLEANSING process after taking medicine.
Three, result
Started diarrhoea after 52 routine patient consumes at 1 ~ 2 hour, average diarrhea number of times is 5.5 times, and diarrhoea continues to stop after 2 ~ 3 hours.Wherein 32 examples reach I level intestinal tract cleaning degree, and 19 examples reach II level intestinal tract cleaning degree, and 1 example is III level intestinal tract cleaning degree, and intestinal tract cleaning effective percentage is 98.1%.
In 52 routine patients, there is mild nausea after taking medicine in 1 example, and 2 examples occur slight stomachache, abdominal discomfort after taking medicine, but all can tolerate, and do not occur because the untoward reaction such as tormina cause bowel preparation failure patient.Intestinal tract cleaning good results.
The pharmaceutical composition that the present invention is used for intestinal tract cleaning adopts scientific formula, reaching the object of intestinal tract cleaning simultaneously, the untoward reaction such as abdominal distention occur less, mild symptoms, have that application safety, intestinal tract cleaning good results, patient are acceptant, better tolerance, the advantage such as easy and simple to handle, cheap, be applicable to the case needing to carry out intestinal tract cleaning art, have higher Clinical practice to be worth.

Claims (2)

1. a pharmaceutical composition for intestinal tract cleaning, the raw material composition and the weight proportion thereof that it is characterized in that making this pharmaceutical composition effective ingredient are: Semen Pharbitidis 4 parts, Cortex Sapii Radicis 4 parts, Rhizoma Iridis Japonicae 5 parts, Semen Abutili 4 parts, Fructus Cannabis 5 parts, Semen Pruni 5 parts, 4 parts, Poria, Herba Sedi 4 parts, the Radix Linderae 4 parts, Rhizoma Cyperi 4 parts, the Radix Aucklandiae 3 parts, 3 parts, Muscovitum, Fructus Amomi 3 parts, Radix Codonopsis 4 parts, Folium Et Cacumen Murrayae 4 parts, 4 parts, Radix Glycyrrhizae.
2. a pharmaceutical composition for intestinal tract cleaning according to claim 1 is for the preparation of the application in the medicine of intestinal tract cleaning.
CN201310600879.9A 2013-11-17 2013-11-17 A pharmaceutical composition for intestinal tract cleaning Expired - Fee Related CN103611050B (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105641521A (en) * 2016-01-27 2016-06-08 扈嘉正 Orally-taken powder with intestinal canal cleaning function
CN115025203B (en) * 2022-07-29 2023-06-02 南充市中医医院 Traditional Chinese medicine composition for preparing intestinal tract before colonoscopy

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101485860A (en) * 2009-02-25 2009-07-22 广州奇星药业有限公司 Chinese medicinal composition for treating constipation and method for producing the same
CN102450350A (en) * 2010-10-22 2012-05-16 高娟 Intestinal tract cleaning tea
CN102845568A (en) * 2011-06-28 2013-01-02 高玮 Tea for moistening intestines

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101485860A (en) * 2009-02-25 2009-07-22 广州奇星药业有限公司 Chinese medicinal composition for treating constipation and method for producing the same
CN102450350A (en) * 2010-10-22 2012-05-16 高娟 Intestinal tract cleaning tea
CN102845568A (en) * 2011-06-28 2013-01-02 高玮 Tea for moistening intestines

Non-Patent Citations (1)

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Title
泻药在便秘时的应用;张中一;《中国初级卫生保健》;19871231(第9期);第32-34页 *

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