CN102716371A - Traditional Chinese medicine composition for curing chronic cough as well as preparation method and usages thereof - Google Patents
Traditional Chinese medicine composition for curing chronic cough as well as preparation method and usages thereof Download PDFInfo
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- CN102716371A CN102716371A CN201210236704XA CN201210236704A CN102716371A CN 102716371 A CN102716371 A CN 102716371A CN 201210236704X A CN201210236704X A CN 201210236704XA CN 201210236704 A CN201210236704 A CN 201210236704A CN 102716371 A CN102716371 A CN 102716371A
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Abstract
The invention discloses a traditional Chinese medicine composition for curing chronic cough as well as a preparation method and usages thereof. The traditional Chinese medicine composition is prepared from reed rhizome, ordate houttuynia, rhizoma anemarrhenae and almond according to a certain proportioning by weight. The composition provided by the invention has an excellent curative effect to chronic cough caused by the deficiency of lung yin.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition that is used to treat chronic cough, belong to the field of Chinese medicines.
Background technology
Chronic cough is common clinical, frequently-occurring disease, also is common respiratory symptom.Doctor trained in Western medicine thinks that this disease is generally caused by water clock syndrome, cough variant asthma, gastroesophageal reflux induced cough, allergia cough behind eosinophilic granulocyte's property bronchitis, the nose; The cause of disease is complicated; Be one and relate to the clinical symptoms that multiple disease is striden section, and often be difficult to obtain to clarify a diagnosis through conventional methods such as history-taking, physical examination and chest film inspections.Generally speaking, the pulmonary lesion that causes because of a variety of causes is behind western medicines in treatment; As take Western medicine and antibacterials for a long time in a large number; Leave over long-term, obstinate chronic cough easily, touching difficult the chance, the lighter can not influence orthobiosis; Weight person then can influence sleep, needs to recover for a long time and treatment.
The traditional Chinese medical science thinks that following reason causes chronic cough easily: the one, and with the passing of time the secular pathological changes repeatedly of pulmonary injures lung yin; The 2nd, in the process of the acute pulmonary lesion of treatment, excessively used resolving phlegm and drying damp medicine or other medicine, thereby injured lung yin; The 3rd, the plain body deficiency of YIN of patient, lack of lung-YIN is prone to meet exopathogen and invades, and is prone to send out cough.
Because the chronic cough course of disease is long, need take medicine for a long time, and Western medicine or antibiotic often have stronger toleration and other side effect and easy relapse after the drug withdrawal.Therefore need a kind of effective and safe drug of treating chronic cough.
Summary of the invention
The object of the invention be to provide a kind of be used to treat chronic cough, Chinese medicine composition safely and effectively.
The present invention seeks to realize through following technical scheme:
A kind of Chinese medicine composition that is used to treat chronic cough, the crude drug of said Chinese medicine composition consists of:
Rhizoma Phragmitis 25-40 weight portion Herba Houttuyniae 20-35 weight portion Rhizoma Anemarrhenae 10-20 weight portion Cortex Mori 8-15 weight portion Semen Armeniacae Amarum 8-15 weight portion.
Preferably, the crude drug of said Chinese medicine composition consists of:
Rhizoma Phragmitis 30-40 weight portion Herba Houttuyniae 20-30 weight portion Rhizoma Anemarrhenae 10-15 weight portion Cortex Mori 8-12 weight portion Semen Armeniacae Amarum 8-12 weight portion.
Preferably, the crude drug of said Chinese medicine composition consists of:
The Rhizoma Phragmitis 30 weight portion Herba Houttuyniae 20 weight portion Rhizoma Anemarrhenaes 10 weight portion Cortex Mori 10 weight portion Semen Armeniacae Amarums 10 weight portions.
Preferably, the crude drug of said Chinese medicine composition consists of:
The Rhizoma Phragmitis 35 weight portion Herba Houttuyniae 25 weight portion Rhizoma Anemarrhenaes 12 weight portion Cortex Mori 8 weight portion Semen Armeniacae Amarums 8 weight portions.
Preferably, the crude drug of said Chinese medicine composition consists of:
The Rhizoma Phragmitis 30 weight portion Herba Houttuyniae 30 weight portion Rhizoma Anemarrhenaes 12 weight portion Cortex Mori 12 weight portion Semen Armeniacae Amarums 12 weight portions.
According to the preferred embodiment of the present invention, the method for preparing of said Chinese medicine composition is preferably:
Get the crude drug of said ratio, add the water (by weight) that water 8-12 doubly measures and extract 2-4 time, each 1-3 hour, filtration, merging filtrate, relative density is the extractum of 1.30-1.40 when being concentrated into 60 ℃, drying is processed the extract fine powder.
According to the preferred embodiment of the present invention, the extract obtained fine powder of above method for preparing adds suitable pharmaceutic adjuvant, processes oral formulations with the method for Chinese medicinal of routine, like tablet, pill, capsule and granule, is preferably capsule or granule.
The present invention also provides above-mentioned Chinese medicine composition to be used for the purposes of the medicine of chronic cough in the preparation treatment.
The inventor carries out prescription according to Chinese medical theory to the chronic cough due to the lack of lung-YIN, and is through long-term clinical practice, evident in efficacy.Rhizoma Phragmitis lung-yin nourishing in the side, profit throat, replenishing body fluid and clearing away heat pathogen are as monarch drug; The detoxifcation of Herba Houttuyniae clearing away lung-heat is also as monarch drug; The Rhizoma Anemarrhenae is the auxiliary Rhizoma Phragmitis lung-yin nourishing of ministerial drug; Cortex Mori is assisted the interior deficiency heat of Herba Houttuyniae lung heat clearing, also is ministerial drug; Semen Armeniacae Amarum is walked lung meridian, and logical lung qi relieving cough and resolving phlegm, and loosening bowel to relieve constipation are adjuvant, thereby meet the pathomechanism of the lung and the large intestine being interior-exteriorly related, thereby reaches lung benefiting the moon, clearind deficient heat, the only effect of dry cough.Among this side, all five kinds of Chinese medicine is the article of the medicine-food two-purpose of State Administration of Traditional Chinese Medicine's promulgation, can take the nourishing lung yin for a long time, has no side effect.Because five kinds of Chinese medicine not only can be used as food but also can nourish lung yin, both can clear up big after being ill, remain in the waste heat of pulmonary after the disease, can nourish lung yin again and recover healthy energy, thereby prevent pulmonary subinfection and pathological changes again, to reach lung benefiting the moon, to end the purpose of dry cough.In addition, five tastes medical material is not found side effect, can take for a long time, more can avoid the side effect of taking antibiotic for a long time and causing.
Chinese medicine composition of the present invention is through secular clinical practice checking.During practical application; Under the prerequisite of the composition principle that does not depart from said pharmaceutical composition; The consumption of the medical material of respectively distinguishing the flavor of in the said pharmaceutical composition is added and subtracted within the specific limits, adjusted in the amount ranges such as the medicine of in claim 1, respectively distinguishing the flavor of, all obtained very notable therapeutic effect.Clinical practice confirms; Chinese medicine composition of the present invention; No matter traditional decocting decoction still extracts the Chinese patent medicine of preparation through method for optimizing, no matter uses separately, still with the Western medicine drug combination; Said pharmaceutical composition has all been obtained unexpected good result in the treatment of chronic cough, and does not find any toxic and side effects.In addition, five tastes crude drug is the article of medicine-food two-purpose in the present composition, can also or be applied in the medicated diet patients as health product and take for a long time.
The specific embodiment
The inventor has carried out secular clinical practice, and the present composition is used for the treatment of chronic cough, and is evident in efficacy, and without any side effects.Below be the part clinical trial case of inventor record, in order to further specifying technique effect of the present invention, but the present invention do not constituted any restriction.
1. physical data
55 patients that choose are the chronic cough patient that outpatient service is accepted for medical treatment, adopt the table of random number method to be divided into matched group and treatment group at random, matched group 27 examples wherein, male's 13 examples wherein, women's 14 examples, age 6-68 year, average 43.5 years old, the course of disease 5 months-6 years; 28 examples are organized in treatment, male's 13 examples wherein, women's 15 examples, age, 8-65 year, average 41.8 years old; The course of disease 2 months-5 years.Two groups of there are no significant on sex, age, course of disease differences have comparability.
2. diagnostic criteria
Diagnostic criteria according to chronic cough in " the Clinics and Practices guide (draft) of cough " of the promulgation in 2005 of Chinese Medical Association's respiratory disease credit meeting asthma group;
Simultaneously, the Chinese medical discrimination typing is: lung yin loss type, and disease is seen dry cough, and it is very brief to cough sound, and expectorant is few or do not have expectorant, dry mouth and throat, or hectic fever in the afternoon, feverish sensation in the palms and soles, the night sweat of sleeping night, red tongue, few tongue, thready and rapid pulse.
3. Therapeutic Method
Matched group: ambroxol hydrochloride 30mg is oral, and every day 3 times, ketotifen 1mg is oral, and 1 time every night, pentoxyverine 25mg is oral, every day 3 times.2 weeks of the course of treatment.
The treatment group: Chinese medicine composition of the present invention is processed granule, and method for preparing is: get Rhizoma Phragmitis 600g, Herba Houttuyniae 400g, Rhizoma Anemarrhenae 200g; Cortex Mori 200g, Semen Armeniacae Amarum 200g, decocte with water is extracted 3 times, and amount of water is respectively 10 times, 8 times, 8 times; Decocting time respectively is 1.5 hours, filters, and merging filtrate, relative density is 1.31～1.34 extractum when being evaporated to 60 ℃; 50 ℃ of drying under reduced pressure are ground into fine powder, add the cyclamate of an amount of soluble dextrins, Icing Sugar and 0.01%, mixing; With alcohol granulation, dry below 40 ℃, process granule 1000g, every gram is equivalent to 1.60 gram crude drugs.Instructions of taking: every day 3 times, each 8g.
4. criterion of therapeutical effect
Curative effect determinate standard with reference to chronic cough in " disease of tcm diagnosis criterion of therapeutical effect ".
Cure: disappearance of cough, relevant symptoms and tongue, pulse condition obviously improve, and do not send out the author more than 2 weeks and are clinical cure.Effectively: cough alleviates, and severe transfers moderate to or moderate transfers to slightly, and relevant symptoms and tongue, pulse condition make moderate progress.Invalid: cough does not have change or increases the weight of.
5. result
The treatment group is cured 18 examples, effective 6 examples, invalid 4 examples, total effective rate 85.71%; Matched group is cured 12 examples, effective 6 examples, and invalid 9 examples, 66.67%, two group of total effective rate of total effective rate compares, and difference has statistical significance.
6. conclusion
For the chronic cough due to the lack of lung-YIN; Compare with the western medicine of routine, the treatment group has obtained excellent curative (total effective rate reaches 85.71%), and medical material of the present invention is formed the article that are medicine-food two-purpose; Drug safety, no toleration and other toxic and side effects.
Below through embodiment the embodiment of Chinese medicine composition of the present invention is described, but said embodiment does not constitute restriction to the present invention.
Embodiment 1
Get Rhizoma Phragmitis 700g, Herba Houttuyniae 500g, Rhizoma Anemarrhenae 240g, Cortex Mori 160g; Semen Armeniacae Amarum 160g, decocte with water is extracted 3 times, and each amount of water is respectively 12,10,8 times of amounts, and each decocting time is 3,2,1 hours; Filter, merging filtrate, relative density is 1.33～1.35 extractum when being evaporated to 60 ℃, spray drying; Process fine powder, add an amount of carboxymethyl starch sodium, microcrystalline Cellulose and magnesium stearate, compacting in flakes.
Embodiment 2
Get Rhizoma Phragmitis 600g, Herba Houttuyniae 400g, Rhizoma Anemarrhenae 200g, Cortex Mori 200g, Semen Armeniacae Amarum 200g; Decocte with water is extracted 3 times, and amount of water is respectively 10 times, 8 times, 8 times, and decocting time respectively is 1.5 hours, filters merging filtrate; Relative density is 1.31～1.34 extractum when being evaporated to 60 ℃, and 50 ℃ of drying under reduced pressure are ground into fine powder, adds the cyclamate of an amount of soluble dextrins, Icing Sugar and 0.01%; Mixing, dry below 40 ℃ with alcohol granulation, process granule.
Embodiment 3
Get Rhizoma Phragmitis 600g, Herba Houttuyniae 600g, Rhizoma Anemarrhenae 240g, Cortex Mori 240g, Semen Armeniacae Amarum 240g; Decocte with water is extracted 3 times, adds 10 times of amounts of water at every turn, decocts 1.5 hours, filters; Merging filtrate, relative density is 1.35～1.40 extractum when being evaporated to 60 ℃, 50 ℃ of drying under reduced pressure are ground into fine powder; Add appropriate amount of starch, with alcohol granulation, hard capsule is dressed up in oven dry.
Claims (8)
1. Chinese medicine composition that is used to treat chronic cough, the crude drug of said Chinese medicine composition consists of:
Rhizoma Phragmitis 25-40 weight portion, Herba Houttuyniae 20-35 weight portion, Rhizoma Anemarrhenae 10-20 weight portion, Cortex Mori 8-15 weight portion, Semen Armeniacae Amarum 8-15 weight portion.
2. Chinese medicine composition according to claim 1 is characterized in that, the crude drug of said Chinese medicine composition consists of:
The Rhizoma Phragmitis 30 weight portion Herba Houttuyniae 20 weight portion Rhizoma Anemarrhenaes 10 weight portion Cortex Mori 10 weight portion Semen Armeniacae Amarums 10 weight portions.
3. Chinese medicine composition according to claim 1 is characterized in that, the crude drug of said Chinese medicine composition consists of:
The Rhizoma Phragmitis 35 weight portion Herba Houttuyniae 25 weight portion Rhizoma Anemarrhenaes 12 weight portion Cortex Mori 8 weight portion Semen Armeniacae Amarums 8 weight portions.
4. Chinese medicine composition according to claim 1 is characterized in that, the crude drug of said Chinese medicine composition consists of:
The Rhizoma Phragmitis 30 weight portion Herba Houttuyniae 30 weight portion Rhizoma Anemarrhenaes 12 weight portion Cortex Mori 12 weight portion Semen Armeniacae Amarums 12 weight portions.
5. according to each described Chinese medicine composition of claim 1-4, it is characterized in that the method for preparing of said Chinese medicine composition comprises:
Get said crude drug, add water extraction 2-4 time that 8-12 by weight doubly measures, each 1-3 hour, filter, merging filtrate, relative density is the extractum of 1.30-1.40 when being concentrated into 60 ℃, drying is pulverized, extract powder.
6. Chinese medicine composition according to claim 5 is characterized in that, said extract powder adds suitable pharmaceutic adjuvant, processes oral formulations with the method for Chinese medicinal of routine.
7. Chinese medicine composition according to claim 6 is characterized in that, said peroral dosage form is tablet, pill, capsule or granule.
8. the purposes that is used for the medicine of chronic cough according to each described Chinese medicine composition of claim 1-7 in the preparation treatment.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103263059A (en) * | 2013-05-23 | 2013-08-28 | 珠海圣原生物科技有限公司 | Solid beverage for clearing away lung-heat, promoting diuresis, reducing phlegm and relieving cough and preparation method thereof |
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| CN1876075A (en) * | 2006-04-28 | 2006-12-13 | 王志岐 | A medicine for treating asthma, acute and chronic bronchitis and preparation method thereof |
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| CN102580037A (en) * | 2012-03-15 | 2012-07-18 | 广东省中医院 | Chinese medicinal composition for treating cough caused by cold-type infection and preparation method thereof |
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| CN1876075A (en) * | 2006-04-28 | 2006-12-13 | 王志岐 | A medicine for treating asthma, acute and chronic bronchitis and preparation method thereof |
| CN102552778A (en) * | 2012-02-20 | 2012-07-11 | 成都中医药大学 | Medicinal composition for treating cough, and preparation method and application thereof |
| CN102580037A (en) * | 2012-03-15 | 2012-07-18 | 广东省中医院 | Chinese medicinal composition for treating cough caused by cold-type infection and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103263059A (en) * | 2013-05-23 | 2013-08-28 | 珠海圣原生物科技有限公司 | Solid beverage for clearing away lung-heat, promoting diuresis, reducing phlegm and relieving cough and preparation method thereof |
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| CN102716371B (en) | 2014-11-05 |
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