CN1876075A - A medicine for treating asthma, acute and chronic bronchitis and preparation method thereof - Google Patents
A medicine for treating asthma, acute and chronic bronchitis and preparation method thereof Download PDFInfo
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- CN1876075A CN1876075A CN 200610016813 CN200610016813A CN1876075A CN 1876075 A CN1876075 A CN 1876075A CN 200610016813 CN200610016813 CN 200610016813 CN 200610016813 A CN200610016813 A CN 200610016813A CN 1876075 A CN1876075 A CN 1876075A
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Abstract
Disclosed is a Chinese medicinal prescription for treating asthma and bronchitis, which is prepared from radical lobelia, apricot seeds, pinellia tuber, baikal skullcap root, gingko, astragalus root, aster, datura flower and schisandra fruit by a predetermined weight proportions, and can be prepared into any of the conventional oral administration dosage forms.
Description
Technical field:
The invention belongs to the field of Chinese medicines, especially relate to a kind of treatment asthma and acute and chronic bronchitic medicine and preparation method thereof.
Background technology:
At present, treatment doctor trained in Western medicine for asthma mainly is the control acute attack, comprise adrenin, theophylline, cholinolytic class, multiple medicine such as glucocorticoid is independent or unite use to reach the purpose of rapid alleviation bronchospasm, the treatment of acute episode of chronic bronchitis and chronic persistence mainly based on infection, go expectorant, antitussive, when panting, use the identical medicine of bronchial asthma could obtain clinical efficacy preferably, but the life-time service said medicine is easy to generate severe complications.Because asthma is because of complexity, and individual variation is bigger, Chinese medicine has accumulated many clinical effective prescriptions as " DINGCHUAN TANG ", " Ephedrae Decoction ", " MAXINGSHIGAN TANG " to treatment of asthma, though asthma and acute and chronic bronchitis are had certain therapeutical effect, but clinical efficacy is not good enough, and cure rate is low.
Summary of the invention:
Technical problem to be solved by this invention provides acute and chronic bronchitic medicine of treatment of a kind of good effect, instant effect and preparation method thereof.
The crude drug composition and the proportioning of medicine of the present invention are as follows:
Herba Lobeliae Chinensis 50-100 weight portion Semen Armeniacae Amarum 30-50 weight portion Rhizoma Pinelliae 30-50 weight portion
Fructus Aristolochiae 100-200 weight portion Radix Scutellariae 100-400 weight portion Semen Ginkgo 20-50 weight portion
Radix Astragali 150-200 weight portion Radix Asteris 100-200 weight portion Flos Daturae 10-50 weight portion
Fructus Schisandrae Chinensis 10-50 weight portion.
The crude drug of medicine of the present invention is formed and proportion optimization is:
The Herba Lobeliae Chinensis 75 weight portion Semen Armeniacae Amarums 30 weight portion Rhizoma Pinelliaes 30 weight portions
Fructus Aristolochiae 150 weight portion Radix Scutellariaes 300 weight portion Semen Ginkgoes 30 weight portions
The Radix Astragali 150 weight portion Radix Asteriss 150 weight portion Flos Daturaes 30 weight portions
Fructus Schisandrae Chinensis 30 weight portions.
The preparation method of medicine of the present invention is as follows:
Each crude drug Herba Lobeliae Chinensis, Semen Armeniacae Amarum, the Rhizoma Pinelliae, Fructus Aristolochiae, Radix Scutellariae, Semen Ginkgo, the Radix Astragali, Radix Asteris, Flos Daturae and Fructus Schisandrae Chinensis are cleaned, decocted with water 1-3 time, each amount of water was not advisable to have powder, and each 1-3 hour, collecting decoction filtered, concentrated put cold; Add triplication 95% ethanol, placement is spent the night, and filters; Adding 40% sodium hydroxide transfers pH value to 7-8, placement is spent the night, filter, decompression filtrate recycling ethanol, spray drying, medicated powder adds volatile oil clathrate compound, and excipient direct through conventional operation or that adding is pharmaceutically accepted is made any in tablet, capsule, granule, oral liquid, injection, the suppository, optimizing injection of the present invention.
Effects such as medicine of the present invention has antitussive, eliminate the phlegm, relieving asthma are used for the treatment of asthma and acute and chronic bronchitis, and without any side effects through clinical observation, effective percentage reaches 95%, and preparation technology is simple, the medicine source is extensive.
Below further set forth the beneficial effect of medicine of the present invention by clinical observation on the therapeutic effect test example.
1. physical data
Accept each 50 example of out-patient and inpatient for medical treatment, wherein male 36 examples, women 64 examples, maximum 72 years old age, minimal ages 13 years old.The course of disease is the longest 40 years, and is the shortest 4 years, occupation: peasant's 80 examples, student's 5 examples, workman's 11 examples, cadre's 4 examples.
Combination of Chinese and Western medicine typing: simple type (phlegm-damp) 24 examples, the type of panting (deficiency and coldness) 76 examples.
Severity extent: slight 2 examples, moderate 29 examples, severe 69 examples merge emphysema 54 examples, pulmonary heart disease 5 examples, other 3 examples.
2, efficacy assessment standard:
Clinic control: cough, expectorant, breathe heavily and take a turn for the better more than ninety percent, the not enough the lighter of symptom, wheezing sound disappears.
Produce effects: cough, expectorant, breathe heavily and forward six to, asthma sound take a turn for the better (+++-+) to more than eighty per cant.
Take a turn for the better: cough, expectorant, breathe heavily and take a turn for the better three to more than fifty percent, wheezing sound take a turn for the better (+++-++-+).
Invalid: cough, expectorant, breathe heavily three one-tenth of improvement less thaies, wheezing sound does not have and changes or increase the weight of, and has 26 examples to present in various degree downward trend during end.
The rabat report: 50 routine philtrums, there are 34 examples to take a turn for the better, effective percentage accounts for 68%.
3, Therapeutic Method
4 milliliters of each intramuscular injection, day notes 2-3 time, one month is a course of treatment.
4, observation of curative effect and therapeutic outcome:
Among the 100 routine patients, through the treatment of a course of treatment, wherein clinic control 21 examples account for 21%; Produce effects 39 examples account for 39%; 35 examples that take a turn for the better account for 35%; Invalid 5 examples account for 5%; Total effective rate 5%.See the following form.
The clinical efficacy contrast table
5, the relation of several factors and curative effect:
(1) relation of typing and curative effect: in this group case, simple type 26 examples, effective percentage accounts for 100%.The type of panting 76 examples, effective percentage accounts for 93.4%.Various curative effect is learned by statistics and is handled P＞0.05, no significant difference.
(2) relation of the state of an illness and curative effect: this is organized in 100 cases, and severe 69 examples account for 94.2%.Moderate 29 examples, effective percentage accounts for 96.6%.Slight 2 examples, effective percentage 100%, the unknown apparent difference P of the state of an illness and curative effect＞0.05.
(3) relation of symptom, sign and curative effect: this is organized in 100 cases, 100 examples of coughing, and effective percentage accounts for 95%.Expectoration 100 examples, effective percentage accounts for 95%.75 examples of panting, effective percentage accounts for 92%.Pulmonary's wheezing sound 72 examples, effective percentage accounts for 93.1%.Rhonchi 94 examples, effective percentage accounts for 94.7%.Moist rale 83 examples, effective percentage accounts for 93.9%.Learn by statistics and handle P＞0.05, no significant difference.
(4) relation of the course of disease and curative effect: this group case effective percentage first course of treatment is 95%.Second the course of treatment effective percentage 100%.As seen, increase with increasing its effective percentage the course of treatment.
6, toxic and side effects:
This is organized 50 routine inpatients and done liver function, routine urinalysis and Electrocardioscopy before and after treatment, finds no unusual change.
7, model case introduction:
Case 1:
Liu Diangong: the man, 62 years old, the peasant now lived the spur village.
The main suit: cough, expectoration, pant surplus in the of 40 year, serious 6 years, be regardless of and show effect repeatedly season, go into the winter for work, can not take part in the work.
Clinical findings: cough is frequent, influences work and sleep.Amount of expectoration is many, and day reaches 200 milliliters, and band is yellow sometimes in vain for color, matter adhesive tape foam.It is serious to pant, and opening mouth and lifting shoulder due to dyspnea exhales many suctions few, do not continue mutually, and lack of appetite abdominal distention, there is creeping chill at the extremity back, and soreness of the waist and knees is unable, and stool is rare after doing earlier, and tongue fur is thick in vain, and deep pulse is counted accurately.Two pulmonary respiration sounds are coarse, are covered with dry rale and wheezing sound, bottom right lung audible and fine bubbling rale, and lung, liver circle descend.
Rabat report: two lung marking obviously strengthen, and Yezhong, bottom right band presents Yun Xuying, every at the 7th intercostal.
Chemical examination tip blood: every milliliter 14600 of leukocyte, the full visual field of expectorant microscopy pus cell, leukocyte 10 to 15/450 *.
Chinese and western medicine typing: asthenic cold type (the chronic bronchitis type of panting, secondary infection merge emphysema).
Treatment: single with the treatment of injection of the present invention through a course of treatment, flat the crouching of complying with one's wishes, cough once in a while, expectorant does not have, and wheezing sound disappears, and two is just normal, thin white fur of tongue, rolling pulse.
The rabat report: two lung marking are strong slightly, and Yezhong, bottom right band cloud wadding shadow scope is dwindled.Chemical examination tip blood, leukocyte is normal.Expectorant microscopy pus cell disappears, leukocyte a little, leave hospital for facing control, regular follow-up is consolidated the curative effect situation.
Case 2:
Sun Limin: the woman, 21 years old, the peasant now lived spring village, Long Jiabao town two societies.
The main suit: year surplus cough, the expectoration ten, be regardless of and show effect repeatedly season, be work, flu postemphasis sooner or later.
Clinical findings: the paroxysmal cough, it is uncomfortable in chest to breathe hard, and with panting, can not put down for sleeping inly sometimes when serious, and amount of expectoration is many, day reaches 100 milliliters, and the color white matter is sticking, and it is rare sometimes to defecate, and white urine is few, and tongue fur is thick in vain, slippery and rapid pulse.
Two lung marking respiratory harshness, two lungs are covered with dry rale, a little bubble of the base of lung.
The rabat report: two lung marking obviously strengthen, and the below presents Yun Xuying outside the two hilus pulumonis portions.Tip blood chemical examination: every milliliter 21400 of leukocyte.The full visual field of expectorant microscopy pus cell, leukocyte 10 to 15/450 *.
Chinese and western medicine diagnosis: phlegm-damp type (simple type chronic bronchitis, secondary infection, acute attack stage).
Treatment: use No. four injection of anti-tracheitis separately, through the treatment of a course of treatment, cough disappears, and expectorant reduces day by day, and by sticking thinning, second week reached no expectorant, and two is just normal, rolling pulse.
The rabat report: two lung marking are strong slightly, and the outer below of two hilus pulumonis cloud wadding shadow scope is dwindled.The chemical examination of tip blood: leukocyte is normal, and expectorant microscopy pus cell disappears, and leukocyte is rare.Consolidate the curative effect situation for facing the control regular follow-up of leaving hospital.
The injection preparation of embodiment 1 medicine of the present invention
Herba Lobeliae Chinensis 75g Semen Armeniacae Amarum 30g Rhizoma Pinelliae 30g Fructus Aristolochiae 150g
Radix Scutellariae 300g Semen Ginkgo 30g Radix Astragali 150g Radix Asteris 150g
Flos Daturae 30g Fructus Schisandrae Chinensis 30g
Preparation method is as follows:
Clean by said ratio weighting raw materials Herba Lobeliae Chinensis, Semen Armeniacae Amarum, the Rhizoma Pinelliae, Fructus Aristolochiae, Radix Scutellariae, Semen Ginkgo, the Radix Astragali, Radix Asteris, Flos Daturae and Fructus Schisandrae Chinensis, decoct with water 3 times, each amount of water was not advisable to have powder, each 1 hour, collecting decoction filters, concentrate put cold; Add triplication 95% ethanol, placement is spent the night, and filters; Add 40% sodium hydroxide and transfer pH value to 7-8, placement is spent the night, and filters, and decompression filtrate recycling ethanol adds the injection water and transfers to 1000ml, and filtration adds 10ml benzyl alcohol and 1ml Tween 80 and heats 10 minutes to dissolving, filters, sterilized 30 minutes for 115 ℃, and embedding, promptly.
The oral liquid preparation of embodiment 2 medicines of the present invention
Herba Lobeliae Chinensis 50g Semen Armeniacae Amarum 30g Rhizoma Pinelliae 35g Fructus Aristolochiae 100g
Radix Scutellariae 100g Semen Ginkgo 20g Radix Astragali 150g Radix Asteris 100g
Flos Daturae 20g Fructus Schisandrae Chinensis 20g
Preparation method is as follows:
Clean by said ratio weighting raw materials Herba Lobeliae Chinensis, Semen Armeniacae Amarum, the Rhizoma Pinelliae, Fructus Aristolochiae, Radix Scutellariae, Semen Ginkgo, the Radix Astragali, Radix Asteris, Flos Daturae and Fructus Schisandrae Chinensis, decoct with water 2 times, each amount of water was not advisable to have powder, each 1.5 hours, collecting decoction filters, concentrate put cold; Add triplication 95% ethanol, placement is spent the night, and filters; Add 40% sodium hydroxide and transfer pH value to 7-8, placement is spent the night, filter, and decompression filtrate recycling ethanol, promptly.
The preparation tablets of embodiment 3 medicines of the present invention
Herba Lobeliae Chinensis 100g Semen Armeniacae Amarum 50g Rhizoma Pinelliae 45g Fructus Aristolochiae 200g
Radix Scutellariae 400g Semen Ginkgo 50g Radix Astragali 180g Radix Asteris 200g
Flos Daturae 40g Fructus Schisandrae Chinensis 40g
Preparation method is as follows:
Each crude drug Herba Lobeliae Chinensis, Semen Armeniacae Amarum, the Rhizoma Pinelliae, Fructus Aristolochiae, Radix Scutellariae, Semen Ginkgo, the Radix Astragali, Radix Asteris, Flos Daturae and Fructus Schisandrae Chinensis are cleaned, decocted with water 2 times, each amount of water was not advisable to have powder, and each 2 hours, collecting decoction filtered, concentrate put cold; Add triplication 95% ethanol, placement is spent the night, and filters; Add 40% sodium hydroxide and transfer pH value to 7-8, placement is spent the night, and filters decompression filtrate recycling ethanol, spray drying, medicated powder adds volatile oil clathrate compound, is wetting agent system granule with 90% ethanol, under 40 ℃ of-50 ℃ of conditions, spray drying, granulate, tabletting are made tablet through conventional technology.
Claims (5)
1, a kind of treatment asthma and acute and chronic bronchitic medicine, it is characterized in that: it is made by following bulk drugs:
Herba Lobeliae Chinensis 50-100 weight portion Semen Armeniacae Amarum 30-50 weight portion Rhizoma Pinelliae 30-50 weight portion
Fructus Aristolochiae 100-200 weight portion Radix Scutellariae 100-400 weight portion Semen Ginkgo 20-50 weight portion
Radix Astragali 150-200 weight portion Radix Asteris 100-200 weight portion Flos Daturae 10-50 weight portion
Fructus Schisandrae Chinensis 10-50 weight portion.
2, a kind of treatment asthma as claimed in claim 1 and acute and chronic bronchitic medicine, it is characterized in that: it is made by following bulk drugs:
The Herba Lobeliae Chinensis 75 weight portion Semen Armeniacae Amarums 30 weight portion Rhizoma Pinelliaes 30 weight portions
Fructus Aristolochiae 150 weight portion Radix Scutellariaes 300 weight portion Semen Ginkgoes 30 weight portions
The Radix Astragali 150 weight portion Radix Asteriss 150 weight portion Flos Daturaes 30 weight portions
Fructus Schisandrae Chinensis 30 weight portions.
3, a kind of treatment asthma as claimed in claim 1 or 2 and acute and chronic bronchitic medicine, it is characterized in that: the dosage form of this medicine is any in tablet, capsule, granule, oral liquid, injection, the suppository.
4, a kind of preparation method for the treatment of asthma and acute and chronic bronchitic medicine as claimed in claim 3, it is characterized in that: this method is:
Each crude drug Herba Lobeliae Chinensis, Semen Armeniacae Amarum, the Rhizoma Pinelliae, Fructus Aristolochiae, Radix Scutellariae, Semen Ginkgo, the Radix Astragali, Radix Asteris, Flos Daturae and Fructus Schisandrae Chinensis are cleaned, decocted with water 1-3 time, each amount of water was not advisable to have powder, and each 1-3 hour, collecting decoction filtered, concentrated put cold; Add triplication 95% ethanol, placement is spent the night, and filters; Adding 40% sodium hydroxide transfers pH value to 7-8, placement is spent the night, filter, decompression filtrate recycling ethanol, spray drying, medicated powder adds volatile oil clathrate compound, and excipient direct through conventional operation or that adding is pharmaceutically accepted is made any in tablet, capsule, granule, oral liquid, injection, the suppository, optimizing injection of the present invention.
5, a kind of preparation method for the treatment of asthma and acute and chronic bronchitic medicine as claimed in claim 4, it is characterized in that: the method for preparing injection is:
Crude drug Herba Lobeliae Chinensis, Semen Armeniacae Amarum, the Rhizoma Pinelliae, Fructus Aristolochiae, Radix Scutellariae, Semen Ginkgo, the Radix Astragali, Radix Asteris, Flos Daturae and Fructus Schisandrae Chinensis are cleaned, decocted with water 3 times, each amount of water was not advisable to have powder, and each 1 hour, collecting decoction filtered, concentrate put cold; Add triplication 95% ethanol, placement is spent the night, and filters; Add 40% sodium hydroxide and transfer pH value to 7-8, placement is spent the night, and filters, and decompression filtrate recycling ethanol adds the injection water and transfers to 1000ml, and filtration adds 10ml benzyl alcohol and 1ml Tween 80 and heats 10 minutes to dissolving, filters, sterilized 30 minutes for 115 ℃, and embedding, promptly.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100168135A CN100371005C (en) | 2006-04-28 | 2006-04-28 | A medicine for treating asthma, acute and chronic bronchitis and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100168135A CN100371005C (en) | 2006-04-28 | 2006-04-28 | A medicine for treating asthma, acute and chronic bronchitis and preparation method thereof |
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| Publication Number | Publication Date |
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| CN1876075A true CN1876075A (en) | 2006-12-13 |
| CN100371005C CN100371005C (en) | 2008-02-27 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102716371A (en) * | 2012-07-10 | 2012-10-10 | 刘海燕 | Traditional Chinese medicine composition for curing chronic cough as well as preparation method and usages thereof |
| WO2020135475A1 (en) * | 2018-12-25 | 2020-07-02 | 北京梅林科技有限公司 | Traditional chinese medicine composition for treating respiratory diseases and preparation method and application thereof |
-
2006
- 2006-04-28 CN CNB2006100168135A patent/CN100371005C/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102716371A (en) * | 2012-07-10 | 2012-10-10 | 刘海燕 | Traditional Chinese medicine composition for curing chronic cough as well as preparation method and usages thereof |
| CN102716371B (en) * | 2012-07-10 | 2014-11-05 | 刘海燕 | Traditional Chinese medicine composition for curing chronic cough as well as preparation method and usages thereof |
| WO2020135475A1 (en) * | 2018-12-25 | 2020-07-02 | 北京梅林科技有限公司 | Traditional chinese medicine composition for treating respiratory diseases and preparation method and application thereof |
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| Publication number | Publication date |
|---|---|
| CN100371005C (en) | 2008-02-27 |
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