CN102145080A - Traditional Chinese medicine composition for eliminating phlegm, relieving cough and preventing asthma and preparation method of traditional Chinese medicine composition - Google Patents
Traditional Chinese medicine composition for eliminating phlegm, relieving cough and preventing asthma and preparation method of traditional Chinese medicine composition Download PDFInfo
- Publication number
- CN102145080A CN102145080A CN2010101097190A CN201010109719A CN102145080A CN 102145080 A CN102145080 A CN 102145080A CN 2010101097190 A CN2010101097190 A CN 2010101097190A CN 201010109719 A CN201010109719 A CN 201010109719A CN 102145080 A CN102145080 A CN 102145080A
- Authority
- CN
- China
- Prior art keywords
- chinese medicine
- medicine composition
- concentration
- volume percent
- value
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a traditional Chinese medicine composition for eliminating phlegm, relieving cough and preventing asthma and a preparation method of the traditional Chinese medicine composition, belonging to the modern field of the traditional Chinese medicine. The active ingredient of the traditional Chinese medicine composition for eliminating phlegm, relieving cough and preventing asthma is prepared by radix physochlainae. The traditional Chinese medicine composition is stable and controllable in quality, improves the curative effect compared with the existing commercial formulation, and reduces dosage for the patients and improved in bioavailability; and the traditional Chinese medicine composition has obvious economic and social benefits.
Description
Technical field
The present invention relates to Chinese medicine composition that a kind of expelling phlegm for arresting cough relievings asthma and preparation method thereof, belong to modern Chinese traditional medicine field.
Background technology
Chronic bronchitis and bronchial asthma are clinical common respiratory system diseases, especially cough, expectorant, asthma shape shows effect repeatedly, causes very big misery to patient.
The Radix Physochlainae drop pill is at the outbreak characteristics of chronic bronchitis patient airway obstruction and sputum hypersecretion, trachea and bronchial smooth muscle can relax rapidly, promote expectoration, relieving cough and asthma, through clinical verification for many years, the Radix Physochlainae drop pill to chronic bronchitis and bronchial asthma and the abundant expectoration that causes and breathe heavily, disease such as the breast abdominal distention is vexed, good curative effect is all arranged.
The preparation method of active component is comparatively simple in the Radix Physochlainae drop pill, and the extraction process that the present invention is directed to Radix Physochlainae medical material in the prior art is optimized, with further raising bioavailability of medicament and curative effect.
Summary of the invention
First technical problem that the present invention will solve provides the Chinese medicine composition that a kind of expelling phlegm for arresting cough is relievingd asthma.
Another technical problem that the present invention will solve provides manufacturing method for above mentioned medicine.
For achieving the above object, the present invention is by the following technical solutions:
A kind of Chinese medicine composition of expectorant cough suppressant and anti-asthmatic, its active component is made by Radix Physochlainae.
Described active component adopts following method to prepare: Radix Physochlainae is ground into coarse powder, is that the concentration of volume percent of 3-5 is alcohol dipping 12-24 hour of 80-95% with pH value; The concentration of volume percent that adds pH value that 15-20 doubly measures and be 3-5 is the 80-95% ethanol percolation, reclaims ethanol, percolate is concentrated into relative density is 1.03-1.10 under the 60-80 ℃ of condition, obtains extractum, and drying under reduced pressure or vacuum drying are pulverized, promptly.
Described Radix Physochlainae being ground into coarse powder, is that the concentration of volume percent of 3-5 is 90-95% alcohol dipping 12-24 hour with pH value; The concentration of volume percent that adds pH value that 15-20 doubly measures and be 3-5 is the 90-95% ethanol percolation, reclaims ethanol, percolate is concentrated into relative density is 1.05-1.08 under the 60-80 ℃ of condition, obtains extractum, and drying under reduced pressure or vacuum drying are pulverized, promptly.
Described Radix Physochlainae being ground into coarse powder, is that 4 concentration of volume percent is 95% alcohol dipping 12-24 hour with pH value; Adding pH value that 15-20 doubly measures and be 4 concentration of volume percent is 95% ethanol percolation, reclaims ethanol, percolate is concentrated into relative density is 1.06-1.08 under the 60-80 ℃ of condition, obtains extractum, and drying under reduced pressure or vacuum drying are pulverized, promptly.
A kind of Chinese medicine composition of expectorant cough suppressant and anti-asthmatic, described pharmaceutical composition also contains the pharmaceutics acceptable auxiliary.
Described pharmaceutics acceptable auxiliary is selected from any one or a few in starch, microcrystalline Cellulose, sucrose, aspartame, dextrin, lactose, Icing Sugar, glucose, sodium chloride, sodium carboxymethyl cellulose, crospolyvinylpyrrolidone, magnesium stearate, micropowder silica gel, vitamin C, cysteine, citric acid and the sodium sulfite.
The dosage form of described Chinese medicine composition is pill, tablet, capsule or oral liquid.The selection of dosage form and the consumption of adjuvant all belong to prior art.
A kind of preparation method of Chinese medicine composition of expectorant cough suppressant and anti-asthmatic: described active component adopts following method to prepare: Radix Physochlainae is ground into coarse powder, is that the concentration of volume percent of 3-5 is alcohol dipping 12-24 hour of 80-95% with pH value; The concentration of volume percent that adds pH value that 15-20 doubly measures and be 3-5 is the 80-95% ethanol percolation, reclaims ethanol, percolate is concentrated into relative density is 1.03-1.10 under the 60-80 ℃ of condition, obtains extractum, and drying under reduced pressure or vacuum drying are pulverized, promptly.
Described Radix Physochlainae being ground into coarse powder, is that the concentration of volume percent of 3-5 is 90-95% alcohol dipping 12-24 hour with pH value; The concentration of volume percent that adds pH value that 15-20 doubly measures and be 3-5 is the 90-95% ethanol percolation, reclaims ethanol, percolate is concentrated into relative density is 1.05-1.08 under the 60-80 ℃ of condition, obtains extractum, and drying under reduced pressure or vacuum drying are pulverized, promptly.
Described Radix Physochlainae being ground into coarse powder, is that 4 concentration of volume percent is 95% alcohol dipping 12-24 hour with pH value; Adding pH value that 15-20 doubly measures and be 4 concentration of volume percent is 95% ethanol percolation, reclaims ethanol, percolate is concentrated into relative density is 1.06-1.08 under the 60-80 ℃ of condition, obtains extractum, and drying under reduced pressure or vacuum drying are pulverized, promptly.
Chinese medicine composition that technical solution of the present invention is related and preparation thereof all have good relieving asthma, phlegm-dispelling functions and certain antitussive effect.Many years ago chronic cough, short-term response; Asthma is seen specially good effect especially; Drinking and smoking a lot, informal dress is effective; Various coughs, asthma all there is good effect.Cross zoopery, we unexpectedly find, the pharmaceutical composition of prepared of the present invention has excellent phlegm-dispelling functions, and relieving asthma, antitussive effect significantly is better than former dosage form and commercially available prod.
Advantage of the present invention is: the present invention uses theory of Chinese medical science analysis prescription to form, and according to the physicochemical property and the Pharmacological action study result of each flavour of a drug ingredient, research has obtained the preparation method of reasonable, stable active component.Adopt technical solution of the present invention, prepared pharmaceutical preparation stable and controllable for quality, that curative effect is compared with existing commercially available dosage form and significantly improved, patient's taking dose reduces, bioavailability improves, have remarkable economical and social benefit.
Describe technical solution of the present invention by the following examples in detail, do not limit practical range of the present invention with this.
The specific embodiment
Embodiment 1: the preparation Chinese medicine extract
One. prescription:
Radix Physochlainae 1000g
Two. method for making:
Radix Physochlainae is ground into coarse powder, is that 3 concentration of volume percent is 80% alcohol dipping 12 hours with pH value; The pH value that adds 15 times of amounts is that 3 concentration of volume percent is 80% ethanol percolation, reclaims ethanol, percolate is concentrated into relative density is 1.03 under the 60-80 ℃ of condition, obtains extractum, and drying under reduced pressure or vacuum drying are pulverized, and promptly get active component 90g of the present invention.
Embodiment 2: the preparation Chinese medicine extract
One. prescription:
Radix Physochlainae 1000g
Two. method for making:
Radix Physochlainae is ground into coarse powder, is that 5 concentration of volume percent is 95% alcohol dipping 24 hours with pH value; The pH value that adds 20 times of amounts is that 5 concentration of volume percent is 95% ethanol percolation, reclaims ethanol, percolate is concentrated into relative density is 1.10 under the 60-80 ℃ of condition, obtains extractum, and drying under reduced pressure or vacuum drying are pulverized, and promptly get active component 100g of the present invention.
Embodiment 3: the preparation Chinese medicine extract
One. prescription:
Radix Physochlainae 1000g
Two. method for making:
Radix Physochlainae is ground into coarse powder, is that 3.5 concentration of volume percent is 85% alcohol dipping 24 hours with pH value; The pH value that adds 15 times of amounts is that 4 concentration of volume percent is 85% ethanol percolation, reclaims ethanol, percolate is concentrated into relative density is 1.05 under the 60-80 ℃ of condition, obtains extractum, and drying under reduced pressure or vacuum drying are pulverized, and promptly get active component 95g of the present invention.
Embodiment 4: the preparation Chinese medicine extract
One. prescription:
Radix Physochlainae 1000g
Two. method for making:
Radix Physochlainae is ground into coarse powder, is that 4 concentration of volume percent is 90% alcohol dipping 24 hours with pH value; The pH value that adds 20 times of amounts is that 4 concentration of volume percent is 90% ethanol percolation, reclaims ethanol, percolate is concentrated into relative density is 1.08 under the 60-80 ℃ of condition, obtains extractum, and drying under reduced pressure or vacuum drying are pulverized, and promptly get active component 98g of the present invention.
Embodiment 5: the preparation Chinese medicine extract
One. prescription:
Radix Physochlainae 1000g
Two. method for making:
Radix Physochlainae is ground into coarse powder, is that 5 concentration of volume percent is 95% alcohol dipping 18 hours with pH value; The pH value that adds 18 times of amounts is that 5 concentration of volume percent is 95% ethanol percolation, reclaims ethanol, percolate is concentrated into relative density is 1.06 under the 60-80 ℃ of condition, obtains extractum, and drying under reduced pressure or vacuum drying are pulverized, and promptly get active component 96g of the present invention.
Embodiment 6: the preparation Chinese medicine extract
One. prescription:
Radix Physochlainae 1000g
Two. method for making:
Radix Physochlainae is ground into coarse powder, is that 4 concentration of volume percent is 90% alcohol dipping 20 hours with pH value; The pH value that adds 18 times of amounts is that 4 concentration of volume percent is 90% ethanol percolation, reclaims ethanol, percolate is concentrated into relative density is 1.07 under the 60-80 ℃ of condition, obtains extractum, and drying under reduced pressure or vacuum drying are pulverized, and promptly get active component 95g of the present invention.
Embodiment 7: the preparation Chinese medicine extract
One. prescription:
Radix Physochlainae 1000g
Two. method for making:
Radix Physochlainae is ground into coarse powder, is that 4 concentration of volume percent is 95% alcohol dipping 24 hours with pH value; The pH value that adds 20 times of amounts is that 4 concentration of volume percent is 95% ethanol percolation, reclaims ethanol, percolate is concentrated into relative density is 1.07 under the 60-80 ℃ of condition, obtains extractum, and drying under reduced pressure or vacuum drying are pulverized, and promptly get active component 92g of the present invention.
Embodiment 8: the preparation tablet
The active component 50g that embodiment 1 obtains adds lactose 10g, microcrystalline Cellulose 10g, and sodium carboxymethyl cellulose 1g, tabletting gets tablet, and every is 0.20g.
Embodiment 9: the preparation drop pill
The active component 100g that embodiment 2 obtains adds Polyethylene Glycol 100g, and dissolving is according to a conventional method dripped and made drop pill, and every ball is 50mg.
Embodiment 10: zoopery
One. material
1. laboratory animal:
Cavia porcellus, male and female have concurrently, 180～220g, regular grade provides credit number by the flourish holy pool breed resultant field of practicing in Shanghai: SCXK (Shanghai)-2002-0012.
The SD rat, body weight 180～220g, the ICR mice, male and female half and half, body weight 18～22g provides by Beijing Vital River Experimental Animals Technology Co., Ltd., the quality certification number: SCXK (capital) 2007-0001.
2. medicine and reagent:
Radix Physochlainae drop pill (commercially available product) and Radix Physochlainae extract extractum (new technology) provide by No.6 Chinese Medicine Factory, Tianjin Zhongxin Pharmaceutical Industry Group Co.
The Radix Physochlainae extract is pressed the preparation of embodiment 7 methods.
The Radix Physochlainae sheet, Jilin Huakang Pharmaceutical Co., Ltd.
The aminophylline sheet, Tianjin Lisheng Pharmaceutical Co., Ltd..
The histamine phosphate standard substance, Nat'l Pharmaceutical ﹠ Biological Products Control Institute.
Ammonium chloride, dragon Xinghua, Asia-Pacific, Tianjin worker's company limited.
Urethane, chemical industry company limited far away in the permanent industry in Beijing.
FUFANG GANCAO PIAN, Tianjin Lisheng Pharmaceutical Co., Ltd..
Strong aqua ammonia, chemical reagent work is learned in Dongli District safe blue Dehua in Tianjin.
3. instrument:
YLS-8A is multi-functional to be lured to breathe heavily to draw and breathes heavily instrument, Shandong Academy of Medical Sciences equipment station.
Two. method
1. to the influence of Cavia porcellus antiasthmatic effect
Selection is drawn and is breathed heavily 48 of the Cavia porcelluss that asthma attack is no more than 120 seconds in the trial test, divide 6 groups at random: the blank group, positive control aminophylline group, Radix Physochlainae drop pill group (commercially available product), the Radix Physochlainae extract is low, high dose group, Radix Physochlainae sheet group (commercially available product), every group 8, give pure water respectively, the Radix Physochlainae drop pill (the 1.5g crude drug/kg), Radix Physochlainae extract (1.5,3.0g crude drug/kg), the Radix Physochlainae sheet (the 1.5g crude drug/kg), gastric infusion is 3 days continuously, every day 1 time, the administration volume is 10ml/kg, and positive drug aminophylline (0.4g/kg) is in experiment administration on the same day 1 time.Each organizes after the last administration 1 hour, place respectively YLS-8A multi-functional lure to breathe heavily to draw to breathe heavily sprayed into 0.5% histamine phosphate solution in the instrument 10 seconds, observe and write down the incubation period (asthma is fallen with tic and is as the criterion, and 6 minutes persons of keeping one's legs are designated as 360 seconds incubation period) that asthma takes place Cavia porcellus.Adopt the SPSS11.0 statistics.
Draw to draw before the prolongation of latency rate of breathing heavily=(draw after the administration to breathe heavily to draw before incubation period-administration and breathe heavily incubation period)/administration and breathe heavily incubation period.
2. mice ammonia is drawn the influence of coughing test
Get 96 of healthy mices, male and female half and half, be divided into 6 groups by weight average: blank group, positive control FUFANG GANCAO PIAN group, Radix Physochlainae drop pill group (commercially available product), Radix Physochlainae extract are low, high dose group, Radix Physochlainae sheet group, every group 16, give respectively pure water, FUFANG GANCAO PIAN (1.35g/kg), Radix Physochlainae drop pill (1.5g crude drug/kg), Radix Physochlainae extract (1.5,3.0g crude drug/kg), Radix Physochlainae sheet (1.5g crude drug/kg); Each organizes the continuous in advance gastric infusion of mice 5 days, and the administration volume is 20ml/kg.Each group placed mice in the inverted 500mL beaker after the last administration in 1 hour, draw and promptly put into beaker after the 0.3mL strong aqua ammonia injects the 50mg cotton balls, (typical case's cough is that the mice abdominal muscle shrinks to observe and write down cough number of times in mouse cough incubation period and 3 minutes immediately, magnify mouth simultaneously, with coughing sound).Adopt the SPSS11.0 statistics.
3. to the influence of rat phlegm-dispelling functions
Get 72 of healthy rats, male and female half and half, be divided into 6 groups by weight average: blank group, positive control ammonium chloride group, Radix Physochlainae drop pill group (commercially available product), Radix Physochlainae extract are low, high dose group, Radix Physochlainae sheet group, every group 16, give respectively pure water, Radix Physochlainae drop pill (1.5g crude drug/kg), Radix Physochlainae extract (1.5,3.0g crude drug/kg), Radix Physochlainae sheet (1.5g crude drug/kg); Each organizes rat continuous gastric infusion 5 days in advance, positive drug ammonium chloride (1.0g/kg), in experiment administration on the same day 1 time, and the administration volume is 20ml/kg.Each group after the last administration 1 hour, urethane is anaesthetized rats by intraperitoneal injection, dorsal position is fixed, cut off neck middle part skin, separate trachea, between thyroid lower edge two cartilaginous rings, insert become mildewed one of thin glass tube of 6cm, make capillary tube just touch the trachea lower surface, so as to drawing trachea rear portion sputum, when sputum is full of in the capillary tube, change another root immediately.The length of drawing sputum with capillary tube is as the index of estimating the medicine phlegm-dispelling functions, and 2-3 hour sputum secretory volume after the record administration is calculated after the administration on average per hour sputum secretory volume.Adopt the SPSS11.0 statistics.
Three. the result:
1. to the influence of Cavia porcellus antiasthmatic effect, the results are shown in Table 1.
The influence of table 1. pair Cavia porcellus antiasthmatic effect (X ± SD. second, n=8)
Annotate: compare * P＜0.05, * * P＜0.01 with matched group; With comparison before the administration, #P＜0.05, ##P＜0.01
The result shows: the Radix Physochlainae drop pill (1.5g crude drug/kg), Radix Physochlainae extract (1.5,3.0g crude drug/kg), the Radix Physochlainae sheet (all breathe heavily than drawing before the administration and obviously prolong (all P＜0.01) incubation period by 1.5g crude drug/kg), and (the 1.5g crude drug/kg), the effect of Radix Physochlainae extract is better than Radix Physochlainae drop pill and Radix Physochlainae sheet under the same dose.Prompting new technology Radix Physochlainae extract multiple dosing histamine phosphate draws to be breathed heavily Cavia porcellus and has certain antiasthmatic effect, and drug effect is better than the Radix Physochlainae drop pill and the Radix Physochlainae sheet of commercially available product.
2. mice ammonia is drawn the influence of coughing test
The influence (n=16) of table 2. pair mice antitussive effect
Compare with matched group: * P＜0.05, compare with the Radix Physochlainae sheet: #P＜0.05 * * P＜0.01
The result shows: the Radix Physochlainae drop pill (1.5g crude drug/kg), Radix Physochlainae extract (1.5,3.0g crude drug/kg), (1.5g crude drug/kg) all can obviously prolong the inductive mouse cough of ammonia incubation period to the Radix Physochlainae sheet, reduce the cough number of times of mice in 3 minutes simultaneously, with matched group significant difference (* P＜0.05, * * P＜0.01) is arranged more all.And (the 1.5g crude drug/kg) effect of Radix Physochlainae extract slightly is better than the Radix Physochlainae drop pill, obviously is better than Radix Physochlainae sheet (incubation period, * P＜0.05) under the same dose.Prompting new technology Radix Physochlainae extract multiple dosing has tangible antitussive effect, and drug effect is better than the Radix Physochlainae drop pill and the Radix Physochlainae sheet of commercially available product.
3. to the influence of rat phlegm-dispelling functions
The influence (n=12) of table 3. pair rat phlegm-dispelling functions
Compare with matched group: * P＜0.05, * * P＜0.01,
The result shows: the Radix Physochlainae drop pill (1.5g crude drug/kg), Radix Physochlainae extract (1.5,3.0g crude drug/kg), (1.5g crude drug/kg) all increases the sputum secretory volume of rat trachea to the Radix Physochlainae sheet, with matched group significant difference (* P＜0.05 is arranged more all, * P＜0.01), but under the same dose (the 1.5g crude drug/kg), the Radix Physochlainae drop pill of the drug effect of Radix Physochlainae extract and commercially available product is suitable with the Radix Physochlainae sheet, there was no significant difference.Prompting new technology Radix Physochlainae extract multiple dosing has tangible promotion expectoration effect.
Claims (10)
1. the Chinese medicine composition of an expectorant cough suppressant and anti-asthmatic, it is characterized in that: its active component is made by Radix Physochlainae.
2. the Chinese medicine composition of a kind of expectorant cough suppressant and anti-asthmatic according to claim 1, it is characterized in that described active component adopts following method to prepare: Radix Physochlainae is ground into coarse powder, is that the concentration of volume percent of 3-5 is alcohol dipping 12-24 hour of 80-95% with pH value; The concentration of volume percent that adds pH value that 15-20 doubly measures and be 3-5 is the 80-95% ethanol percolation, reclaims ethanol, percolate is concentrated into relative density is 1.03-1.10 under the 60-80 ℃ of condition, obtains extractum, and drying under reduced pressure or vacuum drying are pulverized, promptly.
3. the Chinese medicine composition of a kind of expectorant cough suppressant and anti-asthmatic according to claim 2 is characterized in that: described Radix Physochlainae being ground into coarse powder, is that the concentration of volume percent of 3-5 is 90-95% alcohol dipping 12-24 hour with pH value; The concentration of volume percent that adds pH value that 15-20 doubly measures and be 3-5 is the 90-95% ethanol percolation, reclaims ethanol, percolate is concentrated into relative density is 1.05-1.08 under the 60-80 ℃ of condition, obtains extractum, and drying under reduced pressure or vacuum drying are pulverized, promptly.
4. the Chinese medicine composition of a kind of expectorant cough suppressant and anti-asthmatic according to claim 3 is characterized in that: described Radix Physochlainae being ground into coarse powder, is that 4 concentration of volume percent is 95% alcohol dipping 12-24 hour with pH value; Adding pH value that 15-20 doubly measures and be 4 concentration of volume percent is 95% ethanol percolation, reclaims ethanol, percolate is concentrated into relative density is 1.06-1.08 under the 60-80 ℃ of condition, obtains extractum, and drying under reduced pressure or vacuum drying are pulverized, promptly.
5. according to the Chinese medicine composition of any one described a kind of expectorant cough suppressant and anti-asthmatic in the claim 1 to 4, it is characterized in that: described pharmaceutical composition also contains the pharmaceutics acceptable auxiliary.
6. the Chinese medicine composition of a kind of expectorant cough suppressant and anti-asthmatic according to claim 5, it is characterized in that: described pharmaceutics acceptable auxiliary is selected from any one or a few in starch, microcrystalline Cellulose, sucrose, aspartame, dextrin, lactose, Icing Sugar, glucose, sodium chloride, sodium carboxymethyl cellulose, crospolyvinylpyrrolidone, magnesium stearate, micropowder silica gel, vitamin C, cysteine, citric acid and the sodium sulfite.
7. the Chinese medicine composition of a kind of expectorant cough suppressant and anti-asthmatic according to claim 5, it is characterized in that: the dosage form of described Chinese medicine composition is pill, tablet, capsule or oral liquid.
8. the preparation method of the Chinese medicine composition of the described a kind of expectorant cough suppressant and anti-asthmatic of claim 1 is characterized in that: Radix Physochlainae is ground into coarse powder, is that the concentration of volume percent of 3-5 is alcohol dipping 12-24 hour of 80-95% with pH value; The concentration of volume percent that adds pH value that 15-20 doubly measures and be 3-5 is the 80-95% ethanol percolation, reclaims ethanol, percolate is concentrated into relative density is 1.03-1.10 under the 60-80 ℃ of condition, obtains extractum, and drying under reduced pressure or vacuum dry coal are pulverized, promptly.
9. the preparation method of the Chinese medicine composition of a kind of expectorant cough suppressant and anti-asthmatic according to claim 8 is characterized in that: described Radix Physochlainae being ground into coarse powder, is that the concentration of volume percent of 3-5 is 90-95% alcohol dipping 12-24 hour with pH value; The concentration of volume percent that adds pH value that 15-20 doubly measures and be 3-5 is the 90-95% ethanol percolation, reclaims ethanol, percolate is concentrated into relative density is 1.05-1.08 under the 60-80 ℃ of condition, obtains extractum, and drying under reduced pressure or vacuum drying are pulverized, promptly.
10. the preparation method of the Chinese medicine composition of a kind of expectorant cough suppressant and anti-asthmatic according to claim 8 is characterized in that: described Radix Physochlainae being ground into coarse powder, is that 4 concentration of volume percent is 95% alcohol dipping 12-24 hour with pH value; Adding pH value that 15-20 doubly measures and be 4 concentration of volume percent is 95% ethanol percolation, reclaims ethanol, percolate is concentrated into relative density is 1.06-1.08 under the 60-80 ℃ of condition, obtains extractum, and drying under reduced pressure or vacuum drying are pulverized, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010109719A CN102145080B (en) | 2010-02-09 | 2010-02-09 | Traditional Chinese medicine composition for eliminating phlegm, relieving cough and preventing asthma and preparation method of traditional Chinese medicine composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010109719A CN102145080B (en) | 2010-02-09 | 2010-02-09 | Traditional Chinese medicine composition for eliminating phlegm, relieving cough and preventing asthma and preparation method of traditional Chinese medicine composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102145080A true CN102145080A (en) | 2011-08-10 |
| CN102145080B CN102145080B (en) | 2012-10-17 |
Family
ID=44419682
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201010109719A Active CN102145080B (en) | 2010-02-09 | 2010-02-09 | Traditional Chinese medicine composition for eliminating phlegm, relieving cough and preventing asthma and preparation method of traditional Chinese medicine composition |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102145080B (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104383109A (en) * | 2014-11-28 | 2015-03-04 | 天津中新药业集团股份有限公司第六中药厂 | Preparation method of radix physochlainae granules |
| CN104398659A (en) * | 2014-11-28 | 2015-03-11 | 天津中新药业集团股份有限公司第六中药厂 | Preparation method for asthma-relieving radix physochlainae watered pills |
| CN104491162A (en) * | 2014-11-28 | 2015-04-08 | 天津中新药业集团股份有限公司第六中药厂 | Preparation method of funneled physochlaina root asthma-relieving powder |
| CN104491161A (en) * | 2014-11-28 | 2015-04-08 | 天津中新药业集团股份有限公司第六中药厂 | Preparation method of radix physochlainae capsule for relieving asthma |
-
2010
- 2010-02-09 CN CN201010109719A patent/CN102145080B/en active Active
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104383109A (en) * | 2014-11-28 | 2015-03-04 | 天津中新药业集团股份有限公司第六中药厂 | Preparation method of radix physochlainae granules |
| CN104398659A (en) * | 2014-11-28 | 2015-03-11 | 天津中新药业集团股份有限公司第六中药厂 | Preparation method for asthma-relieving radix physochlainae watered pills |
| CN104491162A (en) * | 2014-11-28 | 2015-04-08 | 天津中新药业集团股份有限公司第六中药厂 | Preparation method of funneled physochlaina root asthma-relieving powder |
| CN104491161A (en) * | 2014-11-28 | 2015-04-08 | 天津中新药业集团股份有限公司第六中药厂 | Preparation method of radix physochlainae capsule for relieving asthma |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102145080B (en) | 2012-10-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101428021B (en) | Externally used medicament preparation for quitting tobacco and wine | |
| CN102813801A (en) | Traditional Tibetan medicine for treating cough and preparation method thereof | |
| CN102145080B (en) | Traditional Chinese medicine composition for eliminating phlegm, relieving cough and preventing asthma and preparation method of traditional Chinese medicine composition | |
| CN102145081B (en) | Traditional Chinese medicine composition for eliminating phlegm, relieving cough and relieving asthma and preparation method thereof | |
| CN100415209C (en) | Cough stopping preparation and process for preparing the same | |
| CN102240341B (en) | Asthma-relieving dropping pill preparation method | |
| CN101647885B (en) | Medicine composition for treating coughs | |
| CN102335345B (en) | Chinese medicinal composition for nourishing yin, clearing heat, and moistening lung for arresting cough, and its preparation method | |
| CN1939499B (en) | Jixiangcao extract, its preparation, medicinal composition and uses | |
| CN102485257B (en) | Chinese medicinal composition with lung ventilating, stagnated qi dispersing, heat clearing and phlegm eliminating effects and its preparation method | |
| CN102058809B (en) | Chinese medicine composition for clearing lung, eliminating phlegm and relieving cough and asthma and preparation method thereof | |
| CN103432375A (en) | Preparation method of traditional Chinese medicine extract with effects of ventilating lung, clearing heat, resolving phlegm and relieving cough | |
| CN102485256A (en) | Chinese medicine composition for diffusing lung, depressing qi, clearing heat, and eliminating phlegm and preparation method thereof | |
| CN103893527A (en) | Traditional Chinese medicine composition for nourishing yin, clearing away lung-heat, clearing heat and relieving sore throat and preparation method thereof | |
| CN102058770B (en) | Traditional Chinese medicinal composition for clearing lung, resolving phlegm and relieving cough and asthma and preparation method thereof | |
| CN102145113B (en) | Chinese medical composition capable of resolving phlegm and relieving asthma and preparation method thereof | |
| CN102058768B (en) | Traditional Chinese medicine composition for clearing lung, eliminating phlegm and stopping cough and asthma, and preparation method thereof | |
| CN100411643C (en) | Composition of Chinese traditional medicine for curing cough and asthma, and preparation method | |
| CN102485242B (en) | Chinese medicinal composition for dispelling wind, clearing heat, removing toxins, and benefiting throat, and preparation method thereof | |
| CN115671149B (en) | Ganoderma lucidum spore oil and application thereof in preparing medicines for resisting cancer-induced fatigue | |
| CN106727787A (en) | A kind of alstonia-leaf dispersible tablet and preparation method thereof | |
| CN102485241B (en) | Traditional Chinese medicine composition having functions of dispelling wind, clearing heat, removing toxins and benefiting throat and preparation method thereof | |
| CN102145112A (en) | Chinese medical composition capable of resolving phlegm and relieving asthma and preparation method | |
| CN103110619A (en) | Application of vitexin in preparing drug with cough and asthma relieving action | |
| CN102357184A (en) | Traditional Chinese medicine preparation for treating cough and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CP01 | Change in the name or title of a patent holder |
Address after: 300401 Tianjin city Beichen District North Light Patentee after: Jinyao Darentang Group Co.,Ltd. No 6 Chinese Medicine Factory Address before: 300401 Tianjin city Beichen District North Light Patentee before: No. 6 Traditional Chinese Medicine Factory of Tianjin Zhongxin Pharmaceutical Group Co.,Ltd. |
|
| CP01 | Change in the name or title of a patent holder |