CN102485242B - Chinese medicinal composition for dispelling wind, clearing heat, removing toxins, and benefiting throat, and preparation method thereof - Google Patents
Chinese medicinal composition for dispelling wind, clearing heat, removing toxins, and benefiting throat, and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a Chinese medicinal composition for dispelling wind, clearing heat, removing toxins, and benefiting throat, and a preparation method thereof, belonging to the field of traditional Chinese medicine modernization. The active components of the Chinese medicinal composition comprise 100 weight parts of indigo naturalis, 100 weight parts of licorice, 80 weight parts of myrobalan, 80 weight parts of menthol crystal, 20 weight parts of borneol, and 12 weight parts of calculus bovis factitius. The Chinese medicinal composition disclosed herein has stable and controllable quality, higher curative effect than present commercially available dosage forms, and has outstanding economic and social benefits.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition and preparation method of wind and heat dispersing resolving toxin and disinhibiting the throat, belong to modern Chinese traditional medicine field.
Background technology
Pharyngitis is pharyngeal mucosa, and the inflammation of submucous tissue is often the part of upper respiratory tract infection., according to the length of the course of disease and the difference of pathological change character, be divided into acute pharyngitis, the large class of chronic pharyngitis two.Acute pharyngitis (acutepharyngitis) is pharyngeal mucous membrane, and involves under mucosa and adenoid acute inflammation, often is secondary to acute rhinitis or acute tonsil inflammation afterwards or is the part of upper respiratory tract infection.Be often also the topical manifestations of general disease or be the prodrome of acute infectious disease.Chronic pharyngitis is mainly pharynx mucosa chronic inflammatory disease, and diffuse inflammation is often the part of upper respiratory tract chronic catarrhal inflammation, and the limitation inflammation is many inflammation with the pharynx lymphoid tissue.Chronic pharyngitis is a kind of commonly encountered diseases, frequently-occurring disease clinically, in the Drug therapy of routine, more obstinate, and outbreak repeatedly, common with middle age.
QINGYAN DIWAN is commercially available a kind of Chinese medicine for the treatment of acute pharyngitis, by Indigo Naturalis, Radix Glycyrrhizae, Fructus Chebulae, Borneolum Syntheticum, is made, and has wind and heat dispersing, the effect of resolving toxin and disinhibiting the throat.Be used for acute pharyngitis due to wind-heat, pharyngalgia, dry pharynx, thirsty; Or micro evil wind, heating, red swelling of the pharynx, tongue tip side of red, white and thin fur or BOHUANG, floating and rapid pulse or sliding number, be suitable for acute pharyngitis and see above-mentioned patient.It can effectively treat acute/chronic pharyngitis, anti-fluidity pharyngitis bibliographical information.Have analgesic, analgesia, antipruritic, antiinflammatory, promote the production of body fluid, the effects such as antibacterial, antiviral and enhancing immunity, the effect of oral cavity and respiratory tract cleaning and health care is distinguished.
QINGYAN DIWAN only has drop pill at present.The present invention adopts the R﹠D of modern TCM method, extraction process is improved, to further improving curative effect of medication and preparing novel 'Qingyan '.
Summary of the invention
First technical problem that the present invention will solve is to provide a kind of Chinese medicine composition of wind and heat dispersing resolving toxin and disinhibiting the throat.
Another technical problem that the present invention will solve is to provide the preparation method of said medicine.
For achieving the above object, the present invention is by the following technical solutions:
A kind of Chinese medicine composition of wind and heat dispersing resolving toxin and disinhibiting the throat, its active component is made by the raw material of following parts by weight: 100 parts of Indigo Naturaliss, 100 parts, Radix Glycyrrhizae, 80 parts of Fructus Chebulaes, 80 parts of Mentholums, 20 parts of Borneolum Syntheticums, 12 parts of artificial Calculus Boviss.
Described active component adopts following method to prepare: by proportioning raw materials, take each raw material; Indigo Naturalis, Mentholum, Borneolum Syntheticum, artificial Calculus Bovis pulverize, and obtain fine powder A; The water extraction that Radix Glycyrrhizae is doubly measured with 8-12 2-3 time, each 1-3 hour, merge extractive liquid,, be 60-80% to adding ethanol to make the volume percent content of ethanol in supernatant in extracting solution, standing 6-24 hour; Adding ammonia to pH value to supernatant is 8-11; Reclaim ethanol, the concentrated solution thin up, adding hydrochloric acid to pH value is 1-3, the precipitation washing, be precipitated B; The Fructus Chebulae extracts 2-3 time with 8-12 times of water gaging, each 1-3 hour, merge extractive liquid, is also concentrated, be 50%-80% to adding ethanol to make the concentration of volume percent of the dense middle ethanol of supernatant in concentrated solution, standing 6-24 hour, getting supernatant concentration to relative density under 50-60 ℃ of condition is 1.03-1.10, obtains concentrated solution C; Fine powder A and deposit B, concentrated solution C are merged, and drying, obtain dry thing I.Dry thing I, be the active component of medicine of the present invention.
Described active component adopts following method to prepare: by proportioning raw materials, take each raw material; Indigo Naturalis, Mentholum, Borneolum Syntheticum, artificial Calculus Bovis pulverize, and obtain fine powder A; The water extraction that Radix Glycyrrhizae is doubly measured with 8-10 2-3 time, each 2-3 hour, merge extractive liquid,, be 70-80% to adding ethanol to make the volume percent content of ethanol in supernatant in extracting solution, standing 8-16 hour; Adding ammonia to pH value to supernatant is 8-11; Reclaim ethanol, the concentrated solution thin up, adding hydrochloric acid to pH value is 2-3, the precipitation washing, be precipitated B; The Fructus Chebulae extracts 2-3 time with 10-12 times of water gaging, each 2-3 hour, merge extractive liquid, is also concentrated, be 50%-80% to adding ethanol to make the concentration of volume percent of the dense middle ethanol of supernatant in concentrated solution, standing 8-16 hour, getting supernatant concentration to relative density under 50-60 ℃ of condition is 1.05-1.08, obtains concentrated solution C; Fine powder A and deposit B, concentrated solution C are merged, and drying, obtain dry thing I.
Described active component adopts following method to prepare: by proportioning raw materials, take each raw material; Indigo Naturalis, Mentholum, Borneolum Syntheticum, artificial Calculus Bovis pulverize, and obtain fine powder A; Radix Glycyrrhizae is with the water extraction of 10 times of amounts 2 times, and each 2 hours, merge extractive liquid,, be 80% to adding ethanol to make the volume percent content of ethanol in supernatant in extracting solution, standing 12 hours; Adding ammonia to pH value to supernatant is 8-9; Reclaim ethanol, the concentrated solution thin up, adding hydrochloric acid to pH value is 2-3, the precipitation washing, be precipitated B; The Fructus Chebulae extracts 2 times with 10 times of water gagings, and each 2 hours, merge extractive liquid, was also concentrated, be 60% to adding ethanol to make the concentration of volume percent of the dense middle ethanol of supernatant in concentrated solution, standing 12 hours, getting supernatant concentration to relative density under 50-60 ℃ of condition was 1.05-1.08, obtains concentrated solution C; Fine powder A and deposit B, concentrated solution C are merged, and drying, obtain dry thing I.
Described pharmaceutical composition also contains the acceptable adjuvant of pharmaceutics.
The acceptable adjuvant of described pharmaceutics is selected from any one or a few in starch, microcrystalline Cellulose, sucrose, aspartame, dextrin, lactose, Icing Sugar, glucose, sodium chloride, sodium carboxymethyl cellulose, crospolyvinylpyrrolidone, magnesium stearate, micropowder silica gel, vitamin C, cysteine, citric acid and sodium sulfite.
The dosage form of described Chinese medicine composition is peroral dosage form, includes but not limited to pill, tablet, capsule or oral liquid.The selection of dosage form and the consumption of adjuvant all belong to prior art.
A kind of preparation method of Chinese medicine composition of wind and heat dispersing resolving toxin and disinhibiting the throat, take 100 parts of Indigo Naturaliss, 100 parts, Radix Glycyrrhizae, 80 parts of Fructus Chebulaes, 80 parts of Mentholums, 20 parts of Borneolum Syntheticums, 12 parts of artificial Calculus Boviss; Take each raw material by proportioning raw materials; Indigo Naturalis, Mentholum, Borneolum Syntheticum, artificial Calculus Bovis pulverize, and obtain fine powder A; The water extraction that Radix Glycyrrhizae is doubly measured with 8-12 2-3 time, each 1-3 hour, merge extractive liquid,, be 60-80% to adding ethanol to make the volume percent content of ethanol in supernatant in extracting solution, standing 6-24 hour; Adding ammonia to pH value to supernatant is 8-11; Reclaim ethanol, the concentrated solution thin up, adding hydrochloric acid to pH value is 1-3, the precipitation washing, be precipitated B; The Fructus Chebulae extracts 2-3 time with 8-12 times of water gaging, each 1-3 hour, merge extractive liquid, is also concentrated, be 50%-80% to adding ethanol to make the concentration of volume percent of the dense middle ethanol of supernatant in concentrated solution, standing 6-24 hour, getting supernatant concentration to relative density under 50-60 ℃ of condition is 1.03-1.10, obtains concentrated solution C; Fine powder A and deposit B, concentrated solution C are merged, and drying, obtain dry thing I.Dry thing I, be the active component of medicine of the present invention.
Preferred preparation method is: by proportioning raw materials, take each raw material; Indigo Naturalis, Mentholum, Borneolum Syntheticum, artificial Calculus Bovis pulverize, and obtain fine powder A; The water extraction that Radix Glycyrrhizae is doubly measured with 8-10 2-3 time, each 2-3 hour, merge extractive liquid,, be 70-80% to adding ethanol to make the volume percent content of ethanol in supernatant in extracting solution, standing 8-16 hour; Adding ammonia to pH value to supernatant is 8-11; Reclaim ethanol, the concentrated solution thin up, adding hydrochloric acid to pH value is 2-3, the precipitation washing, be precipitated B; The Fructus Chebulae extracts 2-3 time with 10-12 times of water gaging, each 2-3 hour, merge extractive liquid, is also concentrated, be 50%-80% to adding ethanol to make the concentration of volume percent of the dense middle ethanol of supernatant in concentrated solution, standing 8-16 hour, getting supernatant concentration to relative density under 50-60 ℃ of condition is 1.05-1.08, obtains concentrated solution C; Fine powder A and deposit B, concentrated solution C are merged, and drying, obtain dry thing I.
Most preferred preparation method is: by proportioning raw materials, take each raw material; Indigo Naturalis, Mentholum, Borneolum Syntheticum, artificial Calculus Bovis pulverize, and obtain fine powder A; Radix Glycyrrhizae is with the water extraction of 10 times of amounts 2 times, and each 2 hours, merge extractive liquid,, be 80% to adding ethanol to make the volume percent content of ethanol in supernatant in extracting solution, standing 12 hours; Adding ammonia to pH value to supernatant is 8-9; Reclaim ethanol, the concentrated solution thin up, adding hydrochloric acid to pH value is 2-3, the precipitation washing, be precipitated B; The Fructus Chebulae extracts 2 times with 10 times of water gagings, and each 2 hours, merge extractive liquid, was also concentrated, be 60% to adding ethanol to make the concentration of volume percent of the dense middle ethanol of supernatant in concentrated solution, standing 12 hours, getting supernatant concentration to relative density under 50-60 ℃ of condition was 1.05-1.08, obtains concentrated solution C; Fine powder A and deposit B, concentrated solution C are merged, and drying, obtain dry thing I.
The Chinese medicine composition that technical solution of the present invention is related and preparation thereof all have good wind and heat dispersing, the effect of resolving toxin and disinhibiting the throat.Can be used for acute pharyngitis due to wind-heat, pharyngalgia, dry pharynx, thirsty; Or micro evil wind, heating, red swelling of the pharynx, tongue tip side of red, white and thin fur or BOHUANG, floating and rapid pulse or sliding number, be suitable for acute pharyngitis and see above-mentioned patient.By zoopery, we unexpectedly find, the pharmaceutical composition of technique preparation of the present invention is compared with former dosage form, has excellent antiinflammatory, analgesia and itching-relieving action.
Advantage of the present invention is: the present invention uses theory of Chinese medical science analysis prescription to form, and according to the physicochemical property of each flavour of a drug ingredient and the result of study of pharmacological action, research has obtained the preparation method of reasonable, stable active component.Adopt technical solution of the present invention, prepared stable and controllable for quality, curative effect and compared and significantly improve with existing commercially available dosage form, have significant economic and social benefit.
Describe by the following examples technical solution of the present invention in detail, with this, do not limit practical range of the present invention.
The specific embodiment
Embodiment 1: prepare Chinese medicine extract
One. prescription: Indigo Naturalis 100g Radix Glycyrrhizae 100g Fructus Chebulae 80g Mentholum 80g Borneolum Syntheticum 20g artificial Calculus Bovis 12g
Two. method for making:
Take each raw material by proportioning raw materials; Indigo Naturalis, Mentholum, Borneolum Syntheticum, artificial Calculus Bovis pulverize, and obtain fine powder A; Radix Glycyrrhizae is with the water extraction of 10 times of amounts 2 times, and each 2 hours, merge extractive liquid,, be 70% to adding ethanol to make the volume percent content of ethanol in supernatant in extracting solution, standing 12 hours; Adding ammonia to pH value to supernatant is 9; Reclaim ethanol, the concentrated solution thin up, adding hydrochloric acid to pH value is 3, the precipitation washing, be precipitated B; The Fructus Chebulae extracts 2 times with 10 times of water gagings, and each 2 hours, merge extractive liquid, was also concentrated, be 70% to adding ethanol to make the concentration of volume percent of the dense middle ethanol of supernatant in concentrated solution, standing 12 hours, getting supernatant concentration to relative density under 50-60 ℃ of condition was 1.05, obtains concentrated solution C; Fine powder A and deposit B, concentrated solution C are merged, and drying, obtain dry thing I and be active component 260 grams of the present invention.
Embodiment 2: prepare Chinese medicine extract
One. prescription: Indigo Naturalis 1000g Radix Glycyrrhizae 1000g Fructus Chebulae 800g Mentholum 800g Borneolum Syntheticum 200g artificial Calculus Bovis 120g
Two. method for making:
Take each raw material by proportioning raw materials; Indigo Naturalis, Mentholum, Borneolum Syntheticum, artificial Calculus Bovis pulverize, and obtain fine powder A; Radix Glycyrrhizae is with the water extraction of 10 times of amounts 2 times, and each 2 hours, merge extractive liquid,, be 80% to adding ethanol to make the volume percent content of ethanol in supernatant in extracting solution, standing 12 hours; Adding ammonia to pH value to supernatant is 10; Reclaim ethanol, the concentrated solution thin up, adding hydrochloric acid to pH value is 1, the precipitation washing, be precipitated B; The Fructus Chebulae extracts 2 times with 10 times of water gagings, and each 2 hours, merge extractive liquid, was also concentrated, be 60% to adding ethanol to make the concentration of volume percent of the dense middle ethanol of supernatant in concentrated solution, standing 12 hours, getting supernatant concentration to relative density under 50-60 ℃ of condition was 1.05, obtains concentrated solution C; Fine powder A and deposit B, concentrated solution C are merged, and drying, obtain dry thing I and be active component 2500 grams of the present invention.
Embodiment 3: prepare Chinese medicine extract
One. prescription: Indigo Naturalis 100g Radix Glycyrrhizae 100g Fructus Chebulae 80g Mentholum 80g Borneolum Syntheticum 20g artificial Calculus Bovis 12g
Two. method for making:
Take each raw material by proportioning raw materials; Indigo Naturalis, Mentholum, Borneolum Syntheticum, artificial Calculus Bovis pulverize, and obtain fine powder A; Radix Glycyrrhizae is with the water extraction of 10 times of amounts 2 times, and each 2 hours, merge extractive liquid,, be 80% to adding ethanol to make the volume percent content of ethanol in supernatant in extracting solution, standing 12 hours; Adding ammonia to pH value to supernatant is 8; Reclaim ethanol, the concentrated solution thin up, adding hydrochloric acid to pH value is 2, the precipitation washing, be precipitated B; The Fructus Chebulae extracts 2 times with 10 times of water gagings, and each 2 hours, merge extractive liquid, was also concentrated, be 60% to adding ethanol to make the concentration of volume percent of the dense middle ethanol of supernatant in concentrated solution, standing 12 hours, getting supernatant concentration to relative density under 50-60 ℃ of condition was 1.08, obtains concentrated solution C; Fine powder A and deposit B, concentrated solution C are merged, drying, obtaining dry thing I is active component 284 grams of the present invention.
Embodiment 4: prepare Chinese medicine extract
One. prescription: Indigo Naturalis 100g Radix Glycyrrhizae 100g Fructus Chebulae 80g Mentholum 80g Borneolum Syntheticum 20g artificial Calculus Bovis 12g
Two. method for making:
Take each raw material by proportioning raw materials; Indigo Naturalis, Mentholum, Borneolum Syntheticum, artificial Calculus Bovis pulverize, and obtain fine powder A; Radix Glycyrrhizae is with the water extraction of 8 times of amounts 3 times, and each 1 hour, merge extractive liquid,, be 60% to adding ethanol to make the volume percent content of ethanol in supernatant in extracting solution, standing 6 hours; Adding ammonia to pH value to supernatant is 11; Reclaim ethanol, the concentrated solution thin up, adding hydrochloric acid to pH value is 3, the precipitation washing, be precipitated B; The Fructus Chebulae extracts 3 times with 8 times of water gagings, and each 3 hours, merge extractive liquid, was also concentrated, be 50% to adding ethanol to make the concentration of volume percent of the dense middle ethanol of supernatant in concentrated solution, standing 6 hours, getting supernatant concentration to relative density under 50-60 ℃ of condition was 1.03, obtains concentrated solution C; Fine powder A and deposit B, concentrated solution C are merged, and drying, obtain dry thing I and be active component 327 grams of the present invention.
Embodiment 5: prepare Chinese medicine extract
One. prescription: Indigo Naturalis 100g Radix Glycyrrhizae 100g Fructus Chebulae 80g Mentholum 80g Borneolum Syntheticum 20g artificial Calculus Bovis 12g
Two. method for making:
Take each raw material by proportioning raw materials; Indigo Naturalis, Mentholum, Borneolum Syntheticum, artificial Calculus Bovis pulverize, and obtain fine powder A; Radix Glycyrrhizae is with the water extraction of 12 times of amounts 2 times, and each 1.5 hours, merge extractive liquid,, be 60% to adding ethanol to make the volume percent content of ethanol in supernatant in extracting solution, standing 24 hours; Adding ammonia to pH value to supernatant is 9; Reclaim ethanol, the concentrated solution thin up, adding hydrochloric acid to pH value is 2, the precipitation washing, be precipitated B; The Fructus Chebulae extracts 2 times with 12 times of water gagings, and each 1.5 hours, merge extractive liquid, was also concentrated, be 80% to adding ethanol to make the concentration of volume percent of the dense middle ethanol of supernatant in concentrated solution, standing 24 hours, getting supernatant concentration to relative density under 50-60 ℃ of condition was 1.10, obtains concentrated solution C; Fine powder A and deposit B, concentrated solution C are merged, and drying, obtain dry thing I and be active component 308 grams of the present invention.
Embodiment 6: prepare Chinese medicine extract
One. prescription: Indigo Naturalis 100g Radix Glycyrrhizae 100g Fructus Chebulae 80g Mentholum 80g Borneolum Syntheticum 20g artificial Calculus Bovis 12g
Two. method for making:
Take each raw material by proportioning raw materials; Indigo Naturalis, Mentholum, Borneolum Syntheticum, artificial Calculus Bovis pulverize, and obtain fine powder A; Radix Glycyrrhizae is with the water extraction of 10 times of amounts 2 times, and each 2.5 hours, merge extractive liquid,, be 70% to adding ethanol to make the volume percent content of ethanol in supernatant in extracting solution, standing 8 hours; Adding ammonia to pH value to supernatant is 8; Reclaim ethanol, the concentrated solution thin up, adding hydrochloric acid to pH value is 1, the precipitation washing, be precipitated B; The Fructus Chebulae extracts 2 times with 8 times of water gagings, and each 2.5 hours, merge extractive liquid, was also concentrated, be 50%-80% to adding ethanol to make the concentration of volume percent of the dense middle ethanol of supernatant in concentrated solution, standing 8 hours, getting supernatant concentration to relative density under 50-60 ℃ of condition was 1.04, obtains concentrated solution C; Fine powder A and deposit B, concentrated solution C are merged, and drying, obtain dry thing I and be active component 297 grams of the present invention.
Embodiment 7: prepare Chinese medicine extract
One. prescription: Indigo Naturalis 100g Radix Glycyrrhizae 100g Fructus Chebulae 80g Mentholum 80g Borneolum Syntheticum 20g artificial Calculus Bovis 12g
Two. method for making:
Take each raw material by proportioning raw materials; Indigo Naturalis, Mentholum, Borneolum Syntheticum, artificial Calculus Bovis pulverize, and obtain fine powder A; Radix Glycyrrhizae is with the water extraction of 10 times of amounts 3 times, and each 2 hours, merge extractive liquid,, be 60-80% to adding ethanol to make the volume percent content of ethanol in supernatant in extracting solution, standing 16 hours; Adding ammonia to pH value to supernatant is 10; Reclaim ethanol, the concentrated solution thin up, adding hydrochloric acid to pH value is 1, the precipitation washing, be precipitated B; The Fructus Chebulae extracts 2 times with 10 times of water gagings, and each 2 hours, merge extractive liquid, was also concentrated, be 70% to adding ethanol to make the concentration of volume percent of the dense middle ethanol of supernatant in concentrated solution, standing 16 hours, getting supernatant concentration to relative density under 50-60 ℃ of condition was 1.08, obtains concentrated solution C; Fine powder A and deposit B, concentrated solution C are merged, and drying, obtain dry thing I and be active component 313 grams of the present invention.
Embodiment 8: prepare drop pill
The active component 100g that embodiment 1 obtains, add Polyethylene Glycol 6000200g, and the dripping drop pill, obtain drop pill, and every ball is 30mg.
Embodiment 9: prepare capsule
The active component 1000g that embodiment 2 obtains, add microcrystalline Cellulose 500g, magnesium stearate 2g, and the encapsulating capsule, obtain capsule, and every is 0.35g.
Embodiment 10: the pharmacological testing of moistening and cleaning throat extract antiinflammatory, analgesia, itching-relieving action
1. laboratory animal:
The ICR mice, male and female have concurrently, body weight 18～22g
Above laboratory animal provides by Beijing Vital River Experimental Animals Technology Co., Ltd.
The quality certification number: SCXK (capital) 2007-0001
2. medicine and reagent:
Moistening and cleaning throat extract (embodiment 3 method preparations), QINGYAN DIWAN, produce by No.6 Chinese Medicine Factory, Tianjin Zhongxin Pharmaceutical Industry Group Co;
Aspirin effervescent tablets, produced by AstraZeneca pharmaceutical Co. Ltd;
Chlorphenamine, produced by health and pharmaceutcal corporation, Ltd;
Dextran, produced by Sweden Pharmacia company;
Dimethylbenzene, glacial acetic acid, produce by northization glass purchase and sale center, Tianjin.
3. experimental apparatus
JA1203N type electronic balance, Shanghai Precision Scientific Apparatus Co., Ltd produces.
Two. method and result
1. moistening and cleaning throat extract xylol causes the impact of mice auricle swelling
The ICR mice, male, body weight 20～22g, be divided into 6 groups at random, is respectively basic, normal, high group of blank group, aspirin positive drug group, QINGYAN DIWAN group, moistening and cleaning throat extract.Dosage is: blank group gavage is given purified water; Aspirin positive drug group is filled with 0.3g/kg aspirin medicinal liquid; The QINGYAN DIWAN group is filled with 0.8g crude drug/kg QINGYAN DIWAN medicinal liquid; Basic, normal, high group of moistening and cleaning throat extract is filled with respectively with 0.2,0.4,0.8g crude drug/kg moistening and cleaning throat extract medicinal liquid, the administration volume is 20ml/kg, for three days on end, after the last administration 50 minutes, each group all is coated with dimethylbenzene in the left ear of mice, 20 μ l/ only, take off cervical vertebra execution mice after 5 minutes and cut ears, lay round auricle at two ear corresponding sites respectively with 9mm diameter card punch, auris dextra is normal control, analytical balance is weighed, and calculates swelling (every left auricle of Mus heavily deducts auris dextra sheet weight), adopts the SPSS11.0 statistics.In Table 1.
Table 1. moistening and cleaning throat extract xylol causes the impact of mice auricle swelling
VS blank group
*P＜0.05,
*P＜0.01; VS QINGYAN DIWAN group △ P＜0.05
The moistening and cleaning throat extract all can reduce dimethylbenzene 0.2,0.4, under 0.8g crude drug/kg dosage and cause the mice auricle swelling degree, dose-effect relationship is remarkable, illustrate that xylol causes the Mice Auricle inflammation to the moistening and cleaning throat extract 0.2,0.4, under 0.8g crude drug/kg dosage, have antiinflammation preferably, and the moistening and cleaning throat extract antiinflammatory action under 0.8g crude drug/kg dosage is better than the QINGYAN DIWAN of same dosage.
2. moistening and cleaning throat extract Dichlorodiphenyl Acetate causes the impact of mouse writhing
The ICR mice, male, body weight 18～22g, be divided into 6 groups at random, is respectively basic, normal, high group of blank group, aspirin positive drug group, QINGYAN DIWAN group, moistening and cleaning throat extract.Dosage is: blank group gavage is given purified water; Aspirin positive drug group is filled with 0.3g/kg aspirin medicinal liquid; The QINGYAN DIWAN group is filled with 0.8g crude drug/kg QINGYAN DIWAN medicinal liquid; Basic, normal, high group of moistening and cleaning throat extract is filled with respectively with 0.2,0.4,0.8g crude drug/kg moistening and cleaning throat extract medicinal liquid, the administration volume is 20ml/kg, successive administration 5 days, 1h after the last administration, every mouse peritoneal injection 0.6% acetic acid, volume is 0.1ml/10g, observes the writhing response in 15 minutes after every injected in mice acetic acid (abdominal part indent, stretch hind leg, buttocks is raised) number of times, adopts the SPSS11.0 statistics.In Table 2.
Table 2. moistening and cleaning throat extract Dichlorodiphenyl Acetate causes the impact of mouse writhing
VS blank group
*P＜0.05,
*P＜0.01
The moistening and cleaning throat extract all can reduce acetic acid 0.2,0.4, under 0.8g crude drug/kg dosage and cause the mouse writhing number of times, dose-effect relationship is remarkable, illustrate that Dichlorodiphenyl Acetate causes the mice pain writhing to the moistening and cleaning throat extract 0.2,0.4, under 0.8g crude drug/kg dosage, has analgesic activity preferably.
3. the moistening and cleaning throat extract causes the impact of mice pruritus on dextran
The ICR mice, male and female half and half, body weight 18～22g, be divided into 6 groups at random, is respectively basic, normal, high group of blank group, chlorphenamine positive drug group, QINGYAN DIWAN group, moistening and cleaning throat extract.Dosage is: blank group is filled with purified water; Chlorphenamine positive drug group is filled with 0.004g/kg chlorphenamine medicinal liquid; The QINGYAN DIWAN group is filled with 0.8g crude drug/kg QINGYAN DIWAN medicinal liquid; Basic, normal, high group of moistening and cleaning throat extract is filled with respectively with 0.2,0.4,0.8g crude drug/kg moistening and cleaning throat extract medicinal liquid, the administration volume is 20ml/kg, successive administration 5 days, after the last administration 50 minutes, tail vein injection 1.25mg/kg dextran, administration volume were 0.1ml/10g, mice pruritus latent time and number of times in 30 minutes are (with the mice fore paw head of scratching, the rear solid end trunk of scratching, mouth are stung each position of whole body and are observed as the pruritus indication), adopt the SPSS11.0 statistics.In Table 3.
Table 3. moistening and cleaning throat extract causes the impact of mice pruritus on dextran
VS blank group
*P＜0.05,
*P＜0.01; VS QINGYAN DIWAN group △ P＜0.05
The moistening and cleaning throat extract all can extend dextran 0.2,0.4, under 0.8g crude drug/kg dosage and causes the incubation period of mice pruritus and reduce its pruritus number of times, dose-effect relationship is remarkable, illustrate that the moistening and cleaning throat extract causes the mice pruritus 0.2,0.4, under 0.8g crude drug/kg dosage to dextran, has itching-relieving action preferably; And the moistening and cleaning throat extract itching-relieving action under 0.8g crude drug/kg dosage is better than the QINGYAN DIWAN of same dosage.
Claims (10)
1. the Chinese medicine composition of a wind and heat dispersing resolving toxin and disinhibiting the throat, it is characterized in that: its active component is made by the raw material of following parts by weight: 100 parts of Indigo Naturaliss, 100 parts, Radix Glycyrrhizae, 80 parts of Fructus Chebulaes, 80 parts of Mentholums, 20 parts of Borneolum Syntheticums, 12 parts of artificial Calculus Boviss;
Described active component adopts following method to prepare: by proportioning raw materials, take each raw material; Indigo Naturalis, Mentholum, Borneolum Syntheticum, artificial Calculus Bovis pulverize, and obtain fine powder A; The water extraction that Radix Glycyrrhizae is doubly measured with 8-12 2-3 time, each 1-3 hour, merge extractive liquid,, be 60-80% to adding ethanol to make the volume percent content of ethanol in supernatant in extracting solution, standing 6-24 hour; Adding ammonia to pH value to supernatant is 8-11; Reclaim ethanol, the concentrated solution thin up, adding hydrochloric acid to pH value is 1-3, the precipitation washing, be precipitated B; The Fructus Chebulae extracts 2-3 time with 8-12 times of water gaging, each 1-3 hour, merge extractive liquid, is also concentrated, be 50%-80% to adding ethanol to make the concentration of volume percent of ethanol in supernatant in concentrated solution, standing 6-24 hour, getting supernatant concentration to relative density under 50-60 ℃ of condition is 1.03-1.10, obtains concentrated solution C; Fine powder A and deposit B, concentrated solution C are merged, and drying, obtain dry thing I, is the active component of medicine.
2. the Chinese medicine composition of a kind of wind and heat dispersing resolving toxin and disinhibiting the throat according to claim 1 is characterized in that: describedly by proportioning raw materials, take each raw material; Indigo Naturalis, Mentholum, Borneolum Syntheticum, artificial Calculus Bovis pulverize, and obtain fine powder A; The water extraction that Radix Glycyrrhizae is doubly measured with 8-10 2-3 time, each 2-3 hour, merge extractive liquid,, be 70-80% to adding ethanol to make the volume percent content of ethanol in supernatant in extracting solution, standing 8-16 hour; Adding ammonia to pH value to supernatant is 8-11; Reclaim ethanol, the concentrated solution thin up, adding hydrochloric acid to pH value is 2-3, the precipitation washing, be precipitated B; The Fructus Chebulae extracts 2-3 time with 10-12 times of water gaging, each 2-3 hour, merge extractive liquid, is also concentrated, be 50%-80% to adding ethanol to make the concentration of volume percent of ethanol in supernatant in concentrated solution, standing 8-16 hour, getting supernatant concentration to relative density under 50-60 ℃ of condition is 1.05-1.08, obtains concentrated solution C; Fine powder A and deposit B, concentrated solution C are merged, and drying, obtain dry thing I.
3. the Chinese medicine composition of a kind of wind and heat dispersing resolving toxin and disinhibiting the throat according to claim 2 is characterized in that: describedly by proportioning raw materials, take each raw material; Indigo Naturalis, Mentholum, Borneolum Syntheticum, artificial Calculus Bovis pulverize, and obtain fine powder A; Radix Glycyrrhizae is with the water extraction of 10 times of amounts 2 times, and each 2 hours, merge extractive liquid,, be 80% to adding ethanol to make the volume percent content of ethanol in supernatant in extracting solution, standing 12 hours; Adding ammonia to pH value to supernatant is 8-9; Reclaim ethanol, the concentrated solution thin up, adding hydrochloric acid to pH value is 2-3, the precipitation washing, be precipitated B; The Fructus Chebulae extracts 2 times with 10 times of water gagings, and each 2 hours, merge extractive liquid, was also concentrated, be 60% to adding ethanol to make the concentration of volume percent of ethanol in supernatant in concentrated solution, standing 12 hours, getting supernatant concentration to relative density under 50-60 ℃ of condition was 1.05-1.08, obtains concentrated solution C; Fine powder A and deposit B, concentrated solution C are merged, and drying, obtain dry thing I.
4. the Chinese medicine composition of any one described a kind of wind and heat dispersing resolving toxin and disinhibiting the throat according to claim 1 to 3, it is characterized in that: described pharmaceutical composition also contains the acceptable adjuvant of pharmaceutics.
5. the Chinese medicine composition of a kind of wind and heat dispersing resolving toxin and disinhibiting the throat according to claim 4, it is characterized in that: the acceptable adjuvant of described pharmaceutics is selected from any one or a few in starch, microcrystalline Cellulose, sucrose, aspartame, dextrin, lactose, Icing Sugar, glucose, sodium chloride, sodium carboxymethyl cellulose, crospolyvinylpyrrolidone, magnesium stearate, micropowder silica gel, vitamin C, cysteine, citric acid and sodium sulfite.
6. the Chinese medicine composition of a kind of wind and heat dispersing resolving toxin and disinhibiting the throat according to claim 4, it is characterized in that: the dosage form of described Chinese medicine composition is peroral dosage form.
7. the Chinese medicine composition of a kind of wind and heat dispersing resolving toxin and disinhibiting the throat according to claim 6, it is characterized in that: described peroral dosage form is pill, tablet, capsule or oral liquid.
8. the preparation method of the Chinese medicine composition of a wind and heat dispersing resolving toxin and disinhibiting the throat, take 100 parts of Indigo Naturaliss, 100 parts, Radix Glycyrrhizae, 80 parts of Fructus Chebulaes, 80 parts of Mentholums, 20 parts of Borneolum Syntheticums, 12 parts of artificial Calculus Boviss; Indigo Naturalis, Mentholum, Borneolum Syntheticum, artificial Calculus Bovis pulverize, and obtain fine powder A; The water extraction that Radix Glycyrrhizae is doubly measured with 8-12 2-3 time, each 1-3 hour, merge extractive liquid,, be 60-80% to adding ethanol to make the volume percent content of ethanol in supernatant in extracting solution, standing 6-24 hour; Adding ammonia to pH value to supernatant is 8-11; Reclaim ethanol, the concentrated solution thin up, adding hydrochloric acid to pH value is 1-3, the precipitation washing, be precipitated B; The Fructus Chebulae extracts 2-3 time with 8-12 times of water gaging, each 1-3 hour, merge extractive liquid, is also concentrated, be 50%-80% to adding ethanol to make the concentration of volume percent of ethanol in supernatant in concentrated solution, standing 6-24 hour, getting supernatant concentration to relative density under 50-60 ℃ of condition is 1.03-1.10, obtains concentrated solution C; Fine powder A and deposit B, concentrated solution C are merged, and drying, obtain dry thing I, is the active component of medicine.
9. the preparation method of the Chinese medicine composition of a kind of wind and heat dispersing resolving toxin and disinhibiting the throat according to claim 8 is characterized in that: describedly by proportioning raw materials, take each raw material; Indigo Naturalis, Mentholum, Borneolum Syntheticum, artificial Calculus Bovis pulverize, and obtain fine powder A; The water extraction that Radix Glycyrrhizae is doubly measured with 8-10 2-3 time, each 2-3 hour, merge extractive liquid,, be 70-80% to adding ethanol to make the volume percent content of ethanol in supernatant in extracting solution, standing 8-16 hour; Adding ammonia to pH value to supernatant is 8-11; Reclaim ethanol, the concentrated solution thin up, adding hydrochloric acid to pH value is 2-3, the precipitation washing, be precipitated B; The Fructus Chebulae extracts 2-3 time with 10-12 times of water gaging, each 2-3 hour, merge extractive liquid, is also concentrated, be 50%-80% to adding ethanol to make the concentration of volume percent of ethanol in supernatant in concentrated solution, standing 8-16 hour, getting supernatant concentration to relative density under 50-60 ℃ of condition is 1.05-1.08, obtains concentrated solution C; Fine powder A and deposit B, concentrated solution C are merged, and drying, obtain dry thing I.
10. the preparation method of the Chinese medicine composition of a kind of wind and heat dispersing resolving toxin and disinhibiting the throat according to claim 8 is characterized in that: describedly by proportioning raw materials, take each raw material; Indigo Naturalis, Mentholum, Borneolum Syntheticum, artificial Calculus Bovis pulverize, and obtain fine powder A; Radix Glycyrrhizae is with the water extraction of 10 times of amounts 2 times, and each 2 hours, merge extractive liquid,, be 80% to adding ethanol to make the volume percent content of ethanol in supernatant in extracting solution, standing 12 hours; Adding ammonia to pH value to supernatant is 8-9; Reclaim ethanol, the concentrated solution thin up, adding hydrochloric acid to pH value is 2-3, the precipitation washing, be precipitated B; The Fructus Chebulae extracts 2 times with 10 times of water gagings, and each 2 hours, merge extractive liquid, was also concentrated, be 60% to adding ethanol to make the concentration of volume percent of ethanol in supernatant in concentrated solution, standing 12 hours, getting supernatant concentration to relative density under 50-60 ℃ of condition was 1.05-1.08, obtains concentrated solution C; Fine powder A and deposit B, concentrated solution C are merged, and drying, obtain dry thing I.
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| CN2010105786135A CN102485242B (en) | 2010-12-03 | 2010-12-03 | Chinese medicinal composition for dispelling wind, clearing heat, removing toxins, and benefiting throat, and preparation method thereof |
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| CN1626143A (en) * | 2003-12-11 | 2005-06-15 | 天津天士力制药股份有限公司 | Medication for treating pharyngitis |
| CN101152241A (en) * | 2007-10-11 | 2008-04-02 | 天津中新药业集团股份有限公司第六中药厂 | Quality standard of throat smoothing dropping pills |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1626143A (en) * | 2003-12-11 | 2005-06-15 | 天津天士力制药股份有限公司 | Medication for treating pharyngitis |
| CN101152241A (en) * | 2007-10-11 | 2008-04-02 | 天津中新药业集团股份有限公司第六中药厂 | Quality standard of throat smoothing dropping pills |
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