CN106110131A - A kind of compositions with removing heat from the lung and dissipating phlegm antitussive effect and preparation method thereof - Google Patents

A kind of compositions with removing heat from the lung and dissipating phlegm antitussive effect and preparation method thereof Download PDF

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Publication number
CN106110131A
CN106110131A CN201610774261.8A CN201610774261A CN106110131A CN 106110131 A CN106110131 A CN 106110131A CN 201610774261 A CN201610774261 A CN 201610774261A CN 106110131 A CN106110131 A CN 106110131A
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parts
radix
lung
removing heat
medicine
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闫晓楠
潘勤
耿彤
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ZHONGXIN INNOVA LABORATORIES
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ZHONGXIN INNOVA LABORATORIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/346—Platycodon
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
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    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
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    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract

The invention discloses the Chinese medicine composition of a kind of removing heat from the lung and dissipating phlegm, belong to modern Chinese medicine field.The pharmaceutical composition of a kind of removing heat from the lung and dissipating phlegm antitussive, is made up of the crude drug of following weight: Radix Scutellariae 15 100 parts, Radix Trichosanthis 15 100 parts, Bulbus Fritillariae Thunbergii 15 50 parts, Fructus Aurantii 15 50 parts, Cortex Mori 15 50 parts, Radix Platycodonis 15 50 parts, Radix Et Rhizoma Rhei 15 50 parts, the Rhizoma Anemarrhenae 15 50 parts, Radix Ophiopogonis 15 50 parts, Exocarpium Citri Grandis 15 50 parts, Semen Armeniacae Amarum 15 50 parts, Radix Peucedani 15 50 parts, the Radix Stemonae 15 50 parts, 3 15 parts of Radix Glycyrrhizae.The invention have the advantage that the technical scheme that the present invention provides can prepare quality controllable, curative effect can be given full play to, the rational medicine of taking dose.Avoid use precursor chemicals, Simplified flowsheet, environmental protection in technique, there is significant economic and social benefit.There is significant economic and social benefit.

Description

A kind of compositions with removing heat from the lung and dissipating phlegm antitussive effect and preparation method thereof
Technical field
The present invention relates to the preparation method of a kind of removing heat from the lung and dissipating phlegm antitussive medicine, belong to modern Chinese medicine field.
Background technology
Lung clearing cough suppressing phlegm transforming medicinal ball cures mainly: lung heat clearing, reduces phlegm, antitussive.The cough yellow sputum caused for lung-heat expectorant, chest and diaphragm is not smooth, Laryngalgia hoarseness, is hard and dry.
Prescription: Radix Scutellariae 96g, Radix Trichosanthis 48g, Bulbus Fritillariae Thunbergii 24g, Fructus Aurantii (removing flesh parched with bran) 24g, Radix Platycodonis 24g, Cortex Mori (honey Process) 24g, Radix Et Rhizoma Rhei 12g, Rhizoma Anemarrhenae 12g, 12g Radix Ophiopogonis, Exocarpium Citri Grandis 12g, Semen Armeniacae Amarum (peeling fry) 12g, Radix Peucedani 12g, Radix Stemonae 12g, Radix Glycyrrhizae 3g.
Preparation method: by above 14 tastes, be ground into fine powder, sieve, mixing, with water pill, it is dried, to obtain final product.
Prescription and preparation method are recorded in " Drug Standard of Ministry of Public Health of the Peoples Republic of China " Traditional Chinese medicine historical preparation the 7th, standard Numbering: WS3-B-1433-93.
This prescription with Radix Scutellariae, Radix Trichosanthis as principal agent, the clear eliminating the pathogens from the lung scorching phlegm syndrome of intestines and internal organs of the body internal organs；It is auxiliary with Radix Peucedani, Radix Platycodonis, Bulbus Fritillariae Thunbergii Control abundant expectoration due to lung-heat cough；Relievining asthma with Semen Armeniacae Amarum, Cortex Mori, stemona root cough relieving, Radix Ophiopogonis, the Rhizoma Anemarrhenae nourish lung yin, and Radix Et Rhizoma Rhei is equipped with Radix Trichosanthis Rush down large intestine internal organs heat, with Exocarpium Citri Grandis, Fructus Aurantii activating QI to eliminate phlegm, and prevent Radix Et Rhizoma Rhei, Radix Scutellariae from rushing down clearly too, for adjuvant drug；Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription. Full side ten four Chinese medicines work in coordination with onset, are exclusively used in the cough yellow sputum that treatment abundant expectoration due to lung-heat causes, and chest and diaphragm is not smooth, hoarseness of having sore throat, stool It is dried.For bronchitis, the pneumonia person that occurs above-mentioned symptom.
Owing to current this prescription of lung clearing cough suppressing phlegm transforming medicinal ball only has watered pill one dosage form, traditional handicraft is by its ten four Chinese medicine All being ground into water pill after fine powder, every dose of dose excessive (up to 6g), patient compliance is poor；In terms of quality control still Lack content measuring standard, wayward dosage form quality.This not only will directly affect the curative effect of new drug, also can affect medicine Quality monitoring.In order to solve these problems present in prior art, the present invention uses theory of Chinese medical science to analyze this prescription composition, and With reference to physicochemical property and the result of study of pharmacological action of each flavour of a drug ingredient, according to the physicochemical property of effective ingredient, and with Therapeutical effect has obtained a reasonable set, stable extraction process and the technical scheme of preparation process as foundation, research.According to this One technical scheme can prepare quality controllable, curative effect can be given full play to, the rational medicine of taking dose.Take carry more square Just, patient is prone to accept, and transports and stores and decrease expense, having significant economic and social benefit.
Chinese patent application CN200510122357.8 discloses Chinese medicine composition of a kind of removing heat from the lung and dissipating phlegm and preparation method thereof, bag Include following steps: 1. by composition of raw materials proportioning；2. Radix Scutellariae water extraction；3. Fructus Aurantii, Cortex Mori, Radix Et Rhizoma Rhei, Exocarpium Citri Rubrum, bitter Fructus Pruni Core, Radix Peucedani ethanol extraction；4. Radix Trichosanthis water extraction；5. Bulbus Fritillariae Thunbergii, Radix Platycodonis, the Radix Stemonae, the Rhizoma Anemarrhenae, Radix Ophiopogonis, Radix Glycyrrhizae water extraction； 6. extracting solution A is merged with supernatant B；7. dried object I, II, III of obtaining after said extracted are merged, i.e. obtain compositions Active component；This preparation can add relevant auxiliary materials and prepare corresponding dosage form.
In the method, Radix Scutellariae uses water to put forward the preparation method of rear acid adjustment precipitation.The method Components In Scutellaria Baicalensis cannot extract completely Entirely, extract is impure more, thus affects the therapeutic effect of medicine.The method also needs to use substantial amounts of hydrochloric acid, and hydrochloric acid is Precursor chemicals, use inconvenience, easily pollute environment.Time of repose is long, increases process time and cost, too increases The possibility polluted.The present invention is the innovation for the problems referred to above.
Summary of the invention
The technical problem to be solved in the present invention is to provide the Chinese medicine composition of a kind of removing heat from the lung and dissipating phlegm.
For achieving the above object, the present invention is by the following technical solutions:
A kind of removing heat from the lung and dissipating phlegm antitussive drug extract, is made up of the crude drug of following weight:
Radix Scutellariae 15-100 part, Radix Trichosanthis 15-100 part, Bulbus Fritillariae Thunbergii 15-50 part, Fructus Aurantii 15-50 part, Cortex Mori 15-50 part, Radix Platycodonis 15-50 part, Radix Et Rhizoma Rhei 15-50 part, Rhizoma Anemarrhenae 15-50 part, Radix Ophiopogonis 15-50 part, Exocarpium Citri Grandis 15-50 part, Semen Armeniacae Amarum 15-50 part, front 15-50 part recklessly, Radix Stemonae 15-50 part, Radix Glycyrrhizae 3-15 part；
Described removing heat from the lung and dissipating phlegm antitussive drug extract, is preferably made up of the crude drug of following weight:
Radix Scutellariae 96 parts, Radix Trichosanthis 48 parts, Bulbus Fritillariae Thunbergii 24 parts, Fructus Aurantii (removing flesh parched with bran) 24 parts, Cortex Mori (processed with honey) 24 parts, Radix Platycodonis 24 Part, Radix Et Rhizoma Rhei 12 parts, the Rhizoma Anemarrhenae 12 parts, Radix Ophiopogonis 12 parts, Exocarpium Citri Grandis 12 parts, Semen Armeniacae Amarum (peeling is fried) 12 parts, Radix Peucedani 12 parts, the Radix Stemonae 12 Part, 3 parts of Radix Glycyrrhizae.
Described removing heat from the lung and dissipating phlegm antitussive drug extract, is prepared by following methods: a. is weighed each former by proportioning raw materials Material, standby；
B. all flavour of a drug add 6 ~ 12 times amount water extraction 1 ~ 3 time, and each 1 ~ 3 hour, extracting solution concentrated, and obtains concentrated solution A；
C. concentrated solution A is dried, and obtains dried object I, is the active component of medicine of the present invention；
In above-mentioned steps,
In described step b, concentrated solution proportion is X, 1.03≤X≤1.30.
Preferably
In described step b, concentrated solution proportion is X, 1.10≤X≤1.20；
A kind of removing heat from the lung and dissipating phlegm antitussive medicine, containing said medicine extract of the present invention.
Described medicine possibly together with the acceptable adjuvant of pharmaceutics, adjuvant be chosen as prior art.
Described pharmaceutical composition is peroral dosage form, selected from tablet, capsule, oral liquid, electuary, powder or pill.
A kind of preparation method of removing heat from the lung and dissipating phlegm antitussive drug extract, step is:
A. each raw material is weighed by proportioning raw materials, standby；
B. all flavour of a drug add 6 ~ 12 times amount water extraction 1 ~ 3 time, and each 1 ~ 3 hour, extracting solution concentrated, and obtains concentrated solution A；
C. concentrated solution A is dried, and obtains dried object I, is the active component of medicine of the present invention；
In above-mentioned steps,
In described step b, concentrated solution proportion is X, 1.03≤X≤1.30.
Preferably
In described step b, concentrated solution proportion is X, 1.10≤X≤1.20.
The invention have the advantage that the technical scheme that the present invention provides can prepare quality controllable, curative effect can be given full play to, The rational medicine of taking dose.Avoid use precursor chemicals, Simplified flowsheet, environmental protection in technique, have significantly Economic and social benefit.
Describe in detail below in conjunction with specific embodiment mode, not limitation of the present invention.All open interior according to the present invention Hold this area equivalent done, belong to protection scope of the present invention.
Detailed description of the invention
Embodiment 1: prepare drug extract
One, prescription
Radix Scutellariae 960g, Radix Trichosanthis 480g, Bulbus Fritillariae Thunbergii 240g, Fructus Aurantii (removing flesh parched with bran) 240g, Radix Platycodonis 240g, Cortex Mori (processed with honey) 240g, Radix Et Rhizoma Rhei 120g, Rhizoma Anemarrhenae 120g, 120g Radix Ophiopogonis, Exocarpium Citri Grandis 120g, Semen Armeniacae Amarum (peeling is fried) 120g, Radix Peucedani 120g, the Radix Stemonae 120g, Radix Glycyrrhizae 30g
Two, preparation method
A. each raw material is weighed by proportioning raw materials, standby；
B. all medicine extracting in water 3 times, add water 8 times amount every time, extracts 2 hours, and extracting solution merges, and concentrating under reduced pressure is concentrated Liquid A, concentrated solution density 1.10；
C. concentrated solution A is spray-dried, and obtains dried object I；
Dried object I, is the active component of medicine of the present invention；Obtain the active component 180 grams of medicine of the present invention.
Embodiment 2: prepare drug extract
One, prescription
Radix Scutellariae 960g, Radix Trichosanthis 480g, Bulbus Fritillariae Thunbergii 240g, Fructus Aurantii (removing flesh parched with bran) 240g, Radix Platycodonis 240g, Cortex Mori (processed with honey) 240g, Radix Et Rhizoma Rhei 120g, Rhizoma Anemarrhenae 120g, 120g Radix Ophiopogonis, Exocarpium Citri Grandis 120g, Semen Armeniacae Amarum (peeling is fried) 120g, Radix Peucedani 120g, the Radix Stemonae 120g, Radix Glycyrrhizae 30g
Two, preparation method
A. each raw material is weighed by proportioning raw materials, standby；
B. all medicine extracting in water 2 times, add water 10 times amount for the first time, extracts 2 hours, and add water 8 times amount for the second time, extracts 1.5 little Time, extracting solution merges, and concentrating under reduced pressure obtains concentrated solution A, concentrated solution density 1.25；
C. concentrated solution A drying under reduced pressure, obtains dried object I；
Dried object I, is the active component of medicine of the present invention；Obtain the active component 820 grams of medicine of the present invention.
Embodiment 3: prepare tablet
The drug extract 525g that Example 1 obtains, adds lactose 40g, microcrystalline Cellulose 40g, crospolyvinylpyrrolidone 40g, micropowder silica gel 5g, mix homogeneously, granule processed, tabletting, obtain tablet, every tablet weight 0.35g.
Embodiment 4: prepare granule
The drug extract 240g that Example 2 obtains, with mannitol 100g, xylitol 60g, lactose 30g, mix homogeneously, system Granule, obtains granule, every packed 4g.
Embodiment 5: ammonia is caused the impact of mouse cough by medicine of the present invention
One. material and method:
Medicine of the present invention: prepare by embodiment 1.
Positive control medicine: as disclosed in CN200510122357.8 prepared by method.
Lung clearing cough suppressing phlegm transforming medicinal ball: prepare according to WS3-B-1433-93 method.
Strong aqua ammonia: Dongli District, Tianjin Tai Lande chemical reagent factory
Animal: ICR mice, is provided by Beijing Vital River Experimental Animals Technology Co., Ltd., credit number: SCXK(capital) 2002-0003。
Take healthy ICR mice 84, body weight 18 ~ 22g, be randomly divided into 4 groups, i.e. model control group, medicine group of the present invention (3.6g/kg), positive control medicine group (3.6g/kg), lung clearing cough suppressing phlegm transforming medicinal ball group.Except model control group gives isopyknic pure Outside water purification, other administration groups are all by the continuous gastric infusion of above-mentioned dosage 5 days, and administration volume is 20ml/kg.Each group in last It is administered latter 1 hour, mice is placed in inverted 500ml beaker, draw after 0.3ml strong aqua ammonia injects 50mg cotton balls and put into beaker In, (typical case's cough is that mice abdominal muscle is received to observe and record the cough latent period of each group of mice and mouse cough number of times in 3 minutes Contracting, magnifies mouth, with coughing sound simultaneously), experimental data variance analysis is added up.
Two. result: be shown in Table 1.
The impact on ammonia initiation mouse cough in five days of table 1 medicine of the present invention successive administration ()
Compare * P < 0.05, * * P < 0.01 with model control group and compare # P < 0.05 with positive control medicine group
$ P < 0.05 is compared with lung clearing cough suppressing phlegm transforming medicinal ball group
Result shows: medicine group of the present invention, positive control medicine group compare with model control group, and medicine group of the present invention is with positive Property control drug group, lung clearing cough suppressing phlegm transforming medicinal ball group compare, and all have significant difference (P < 0.05, P < 0.01), point out medicine of the present invention Thing can be obviously prolonged the mouse cough incubation period of ammonia induction, reduces cough number of times.In the case of dosage is identical, and sun Property control drug group is compared, and medicine of the present invention can significantly reduce the cough number of times of ammonia inducing mouse, and and positive control drug Thing group is compared with lung clearing cough suppressing phlegm transforming medicinal group and is respectively provided with significant difference (P < 0.05), illustrates that medicine of the present invention has obvious antitussive to make With and effect be better than positive control medicine and lung clearing cough suppressing phlegm transforming medicinal ball.
Embodiment 6: the medicine of the present invention impact on mice auricle swelling
One. material and method:
Medicine of the present invention: prepare by embodiment 1.
Positive control medicine: as disclosed in CN200510122357.8 prepared by method.
Lung clearing cough suppressing phlegm transforming medicinal ball: prepare according to WS3-B-1433-93 method.
Dimethylbenzene: Dongli District, Tianjin Tai Lande chemical reagent factory
Animal: ICR mice, is provided by Beijing Vital River Experimental Animals Technology Co., Ltd., credit number: SCXK(capital) 2002-0003。
Take healthy ICR mice 84, body weight 18 ~ 22g, be randomly divided into 4 groups, i.e. model control group, medicine group of the present invention (1g/kg), positive control medicine group (1g/kg), lung clearing cough suppressing phlegm transforming medicinal ball group.Except model control group gives isopyknic pure water Outward, other administration groups are all by above-mentioned dosage gastric infusion.After being administered 30 minutes, measure every mouse right ear thickness.Measure Every mouse right ear is coated with dimethylbenzene 20 μ L and causes inflammation afterwards, after 60 minutes, again measures auris dextra thickness.After causing inflammation, auris dextra thickness just deducts Constant value is ear swelling degree.The results are shown in Table 2.
Two, result: be shown in Table 2
Table 2 medicine of the present invention xylol to mice auricle swelling impact ()
Compare * P < 0.05, * * P < 0.01 with model control group and compare # P < 0.05 with positive control medicine group
$ P < 0.05 is compared with lung clearing cough suppressing phlegm transforming medicinal ball group
Result shows: medicine group of the present invention, positive control medicine group compare with model control group, and medicine group of the present invention is with positive Property control drug group, lung clearing cough suppressing phlegm transforming medicinal ball group compare, and all have significant difference (P < 0.05, P < 0.01), point out medicine of the present invention The ear that thing can substantially suppress caused by dimethylbenzene xylene inflammation 1h to cause swells, and has the effect substantially suppressing inflammation.In the feelings that dosage is identical Under condition, comparing with positive control medicine group and lung clearing cough suppressing phlegm transforming medicinal ball group, medicine of the present invention can substantially suppress caused by dimethylbenzene xylene inflammation 1h The ear caused swells, and has the effect substantially suppressing inflammation, and equal compared with positive control medicine group and lung clearing cough suppressing phlegm transforming medicinal group There is significant difference (P < 0.05), illustrate that medicine of the present invention has significantly suppression inflammatory effect and effect to be better than positive control drug Thing and lung clearing cough suppressing phlegm transforming medicinal ball.

Claims (10)

1. a removing heat from the lung and dissipating phlegm antitussive drug extract, it is characterised in that be made up of the crude drug of following weight:
Radix Scutellariae 15-100 part, Radix Trichosanthis 15-100 part, Bulbus Fritillariae Thunbergii 15-50 part, Fructus Aurantii 15-50 part, Cortex Mori 15-50 part, Radix Platycodonis 15-50 part, Radix Et Rhizoma Rhei 15-50 part, Rhizoma Anemarrhenae 15-50 part, Radix Ophiopogonis 15-50 part, Exocarpium Citri Grandis 15-50 part, Semen Armeniacae Amarum 15-50 part, front 15-50 part recklessly, Radix Stemonae 15-50 part, Radix Glycyrrhizae 3-15 part.
A kind of removing heat from the lung and dissipating phlegm antitussive drug extract the most according to claim 1, it is characterised in that joined by following weight portion The crude drug of ratio is made:
Radix Scutellariae 96 parts, Radix Trichosanthis 48 parts, Bulbus Fritillariae Thunbergii 24 parts, Fructus Aurantii (removing flesh parched with bran) 24 parts, Cortex Mori (processed with honey) 24 parts, Radix Platycodonis 24 Part, Radix Et Rhizoma Rhei 12 parts, the Rhizoma Anemarrhenae 12 parts, Radix Ophiopogonis 12 parts, Exocarpium Citri Grandis 12 parts, Semen Armeniacae Amarum (peeling is fried) 12 parts, Radix Peucedani 12 parts, the Radix Stemonae 12 Part, 3 parts of Radix Glycyrrhizae.
A kind of removing heat from the lung and dissipating phlegm antitussive drug extract the most according to claim 1, it is characterised in that prepared by following methods Obtain:
A. each raw material is weighed by proportioning raw materials, standby；
B. all flavour of a drug add 6 ~ 12 times amount water extraction 1 ~ 3 time, and each 1 ~ 3 hour, extracting solution concentrated, and obtains concentrated solution A；
C. concentrated solution A is dried, and obtains dried object I, is the active component of medicine of the present invention.
A kind of removing heat from the lung and dissipating phlegm antitussive drug extract the most according to claim 3, it is characterised in that:
In described step b, concentrated solution proportion is X, 1.03≤X≤1.30.
A kind of removing heat from the lung and dissipating phlegm antitussive drug extract the most according to claim 4, it is characterised in that:
In described step b, concentrated solution proportion is X, 1.10≤X≤1.20.
6. a removing heat from the lung and dissipating phlegm antitussive medicine, it is characterised in that: carry containing the medicine in any of the one of claim 1 to 6 Take thing.
A kind of removing heat from the lung and dissipating phlegm antitussive medicine the most according to claim 6, it is characterised in that: described medicine is possibly together with pharmaceutics Acceptable adjuvant.
8. according to a kind of removing heat from the lung and dissipating phlegm antitussive medicine described in claim 6 or 7, it is characterised in that: described pharmaceutical composition is Peroral dosage form, selected from tablet, capsule, oral liquid, electuary, powder or pill.
9. the preparation method of a kind of removing heat from the lung and dissipating phlegm antitussive drug extract described in claim 1 or 2, it is characterised in that step For:
A. each raw material is weighed by proportioning raw materials, standby；
B. all flavour of a drug add 6 ~ 12 times amount water extraction 1 ~ 3 time, and each 1 ~ 3 hour, extracting solution concentrated, and obtains concentrated solution A；
C. concentrated solution A is dried, and obtains dried object I, is the active component of medicine of the present invention.
10. the preparation method of a kind of removing heat from the lung and dissipating phlegm antitussive drug extract described in claim 1 or 2, it is characterised in that:
In described step b, concentrated solution proportion is X, 1.03≤X≤1.30, preferably 1.10≤X≤1.20.
CN201610774261.8A 2016-08-31 2016-08-31 A kind of compositions with removing heat from the lung and dissipating phlegm antitussive effect and preparation method thereof Pending CN106110131A (en)

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Country Status (1)

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Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
左言富等: "《简明中成药辞典》", 31 October 2002, 上海科学技术出版社 *

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Application publication date: 20161116