CN102145092A - Chinese medical composition capable of dispelling wind and relieving fever and preparation method - Google Patents
Chinese medical composition capable of dispelling wind and relieving fever and preparation method Download PDFInfo
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Abstract
The invention discloses a Chinese medical composition capable of dispelling wind and relieving fever, belonging to the field of modernization of traditional Chinese medicines. The active ingredients of the Chinese medical composition capable of dispelling wind and relieving fever is prepared from the following raw materials in parts by weight: 30 parts of notopterygium root, 60 parts of ma-huang, 45 parts of cassia twig, 45 parts of schizonepeta spike, 30 parts of saposhnikovia divaricata, 30 parts of angelica dahurica, 30 parts of hemlock parsley, 15 parts of grass-leaved sweetflag, 45 parts of root of kudzu vine, 15 parts of mint, 60 parts of bitter almond, 30 parts of angelica, 60 parts of radix scutellariae and 30 parts of balloon flower. The invention has the advantages of simple process, stable and controllable quality, remarkably improved curative effect as compared with a currently marketed preparation, reduced patient administration dosage, improved bioavailability and remarkable economic and social benefits.
Description
Technical field
The present invention relates to Chinese medicine composition of a kind of dispeling wind and relieving fever and preparation method thereof, belong to modern Chinese traditional medicine field.
Background technology
GANMAO RUANJIAONANG comes from traditional Chinese medical science tradition name side " Ephedrae Decoction " and " Notoptreygium Decoction of Nine Ingredients " plus-minus, adopting medical materials such as Herba Ephedrae, Ramulus Cinnamomi, Herba Schizonepetae, Radix Scutellariae, Semen Armeniacae Amarum, Rhizoma Et Radix Notopterygii, Rhizoma Chuanxiong, Radix Saposhnikoviae, Radix Puerariae, Herba Menthae, the Radix Angelicae Dahuricae, Rhizoma Acori Graminei, Radix Angelicae Sinensis, Radix Platycodonis to make, is the good recipe of treatment anemofrigid cold.Side's epheday intermedia, the hot temperature of Ramulus Cinnamomi are dispersed. relieving the exterior syndrome by diaphoresis. and impel the heresy of wind and cold to separate with antiperspirant. be all monarch drug.Rhizoma Et Radix Notopterygii, Radix Saposhnikoviae, Herba Schizonepetae, white base of a fruit relieving the exterior syndrome with drugs of pungent in flavor and warm in nature, antalgic. strengthen the merit of monarch drug dispersing wind-cold. Radix Angelicae Sinensis, Rhizoma Chuanxiong promoting blood circulation, dredging meridian and relieving pain, above Six-element are ministerial drug altogether.Semen Armeniacae Amarum, Radix Platycodonis, Herba Menthae sore-throat relieving. Rhizoma Acori Graminei activating QI to eliminate phlegm, Radix Puerariae, Radix Scutellariae expelling pathogenic factors from muscles for clearing heat. be all adjuvant drug.All medicines share, and are total to the long memorial wind, dissipating cold, the merit of the heat clearing away of inducing sweat.
Modern study, but GANMAO RUANJIAONANG dispeling wind and relieving fever, have tangible diaphoresis, analgesic, calm, antitussive, eliminate the phlegm, relieving asthma, multiple effect such as antiinflammatory, antiviral, what be used for that affection of exogenous wind-cold causes has a headache and fever, the nasal obstruction watery nasal discharge, aversion to cold is lossless, and joint is ached, laryngopharynx swelling and pain, diseases such as treatment influenza, flu and cough have good efficacy.
The method for making of GANMAO RUANJIAONANG is: ten four Chinese medicine materials of recipe quantity, and Herba Schizonepetae, Herba Menthae are extracted volatile oil, and the leaching medicinal liquid; 12 flavors such as all the other Rhizoma Et Radix Notopterygiis, with 80% alcohol heating reflux twice, 2 hours for the first time, 1 hour for the second time, filter merging filtrate, reclaim ethanol to there not being the alcohol flavor, merge with above-mentioned filtrate, being concentrated into relative density is the thick paste of 1.30 (50 ℃ of heat are surveyed), drying under reduced pressure, be ground into fine powder, add vegetable oil and above-mentioned volatile oil, mixing, make soft capsule, promptly.
This method for making has only been selected the volatile oil component of Herba Schizonepetae and Herba Menthae for use.By research, we find to have other effective ingredient probably in this two flavors medical material, therefore, are necessary to improve the preparation technology of active component.
Summary of the invention
First technical problem that the present invention will solve provides a kind of Chinese medicine composition of dispeling wind and relieving fever.
Another technical problem that the present invention will solve provides manufacturing method for above mentioned medicine.
For achieving the above object, the present invention is by the following technical solutions:
A kind of Chinese medicine composition of dispeling wind and relieving fever, its active component is made by the raw material of following parts by weight: 30 parts of Rhizoma Et Radix Notopterygiis, 60 parts in Herba Ephedrae, 45 parts of Ramulus Cinnamomi, 45 parts of Herba Schizonepetaes, 30 parts of Radix Saposhnikoviaes, 30 parts of the Radixs Angelicae Dahuricae, 30 parts of Rhizoma Chuanxiongs, 15 parts of Rhizoma Acori Graminei, 45 parts of Radix Puerariaes, 15 parts of Herba Menthaes, 60 parts of Semen Armeniacae Amarums, 30 parts of Radix Angelicae Sinensis, 60 parts of Radix Scutellariaes, 30 parts of Radix Platycodoniss.
Described active component adopts following method to prepare: take by weighing each raw material by proportioning raw materials; The full presciption medicine material is doubly measured ethanol extraction 2-3 time that concentration of volume percent is 60-80% with 6-10, and each 1-3 hour, merge extractive liquid, was concentrated into that relative density is 1.03-1.10 under the 50-60 ℃ of condition; Drying under reduced pressure or spray drying, promptly.
Described full presciption medicine material is doubly measured ethanol extraction 2-3 time that concentration of volume percent is 65-75% with 8-10, and each 2-3 hour, merge extractive liquid, was concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition; Drying under reduced pressure or spray drying, promptly.
Described full presciption medicine material is 70% ethanol extraction 2 times with 8 times of amount concentration of volume percent, and each 2 hours, merge extractive liquid, was concentrated into that relative density is 1.06-1.08 under the 50-60 ℃ of condition; Drying under reduced pressure or spray drying, promptly.
Described pharmaceutical composition also contains the pharmaceutics acceptable auxiliary.
Described pharmaceutics acceptable auxiliary is selected from any one or a few in starch, microcrystalline Cellulose, sucrose, dextrin, lactose, Icing Sugar, glucose, sodium chloride, sodium carboxymethyl cellulose, crospolyvinylpyrrolidone, magnesium stearate, micropowder silica gel, vitamin C, cysteine, citric acid and the sodium sulfite.
The dosage form of described Chinese medicine composition is pill, tablet, capsule or oral liquid.The selection of dosage form and adjuvant belongs to prior art.
A kind of preparation method of Chinese medicine composition of dispeling wind and relieving fever takes by weighing 30 parts of Rhizoma Et Radix Notopterygiis, 60 parts in Herba Ephedrae, 45 parts of Ramulus Cinnamomi, 45 parts of Herba Schizonepetaes, 30 parts of Radix Saposhnikoviaes, 30 parts of the Radixs Angelicae Dahuricae, 30 parts of Rhizoma Chuanxiongs, 15 parts of Rhizoma Acori Graminei, 45 parts of Radix Puerariaes, 15 parts of Herba Menthaes, 60 parts of Semen Armeniacae Amarums, 30 parts of Radix Angelicae Sinensis, 60 parts of Radix Scutellariaes, 30 parts of Radix Platycodoniss; Take by weighing each raw material by proportioning raw materials; The full presciption medicine material is doubly measured ethanol extraction 2-3 time that concentration of volume percent is 60-80% with 6-10, and each 1-3 hour, merge extractive liquid, was concentrated into that relative density is 1.03-1.10 under the 50-60 ℃ of condition; Drying under reduced pressure or spray drying, promptly.
Described full presciption medicine material is doubly measured ethanol extraction 2-3 time that concentration of volume percent is 65-75% with 8-10, and each 2-3 hour, merge extractive liquid, was concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition; Drying under reduced pressure or spray drying, promptly.
Described full presciption medicine material is 70% ethanol extraction 2 times with 8 times of amount concentration of volume percent, and each 2 hours, merge extractive liquid, was concentrated into that relative density is 1.06-1.08 under the 50-60 ℃ of condition; Drying under reduced pressure or spray drying, promptly.
Chinese medicine composition that technical solution of the present invention is related and preparation thereof all have good dispeling wind and relieving fever, diaphoresis calmness, antitussive, eliminate the phlegm, relieving asthma, effect such as antiinflammatory, antiviral.By zoopery, we find that unexpectedly the pharmaceutical composition of prepared of the present invention has the trivial solution heat effect than prior art, and its antiinflammatory, analgesic activity and prior art are suitable.
Advantage of the present invention is: the present invention uses theory of Chinese medical science analysis prescription to form, and according to the physicochemical property and the Pharmacological action study result of each flavour of a drug ingredient, research has obtained the preparation method of simple, reasonable, stable active component.Adopt technical solution of the present invention, prepared pharmaceutical preparation stable and controllable for quality, that curative effect is compared with existing commercially available dosage form and significantly improved, patient's taking dose reduces, bioavailability improves, have remarkable economical and social benefit.
Describe technical solution of the present invention by the following examples in detail, do not limit practical range of the present invention with this.
The specific embodiment
Embodiment 1: the preparation Chinese medicine extract
One. prescription:
Rhizoma Et Radix Notopterygii 30g Herba Ephedrae 60g Ramulus Cinnamomi 45g Herba Schizonepetae 45g Radix Saposhnikoviae 30g Radix Angelicae Dahuricae 30g Rhizoma Chuanxiong 30g Rhizoma Acori Graminei 15g Radix Puerariae 45g Herba Menthae 15g Semen Armeniacae Amarum 60g Radix Angelicae Sinensis 30g Radix Scutellariae 60g Radix Platycodonis 30g
Two. method for making:
Take by weighing each raw material by proportioning raw materials; The full presciption medicine material adds 10 times of amounts, 8 times of amount concentration of volume percent are 60% ethanol extraction twice, each 2.5h, and merge extractive liquid, is concentrated into that relative density is 1.05 under the 50-60 ℃ of condition, and drying under reduced pressure obtains active component 140 grams of medicine of the present invention.
Embodiment 2: the preparation Chinese medicine extract
One. prescription:
Rhizoma Et Radix Notopterygii 300g Herba Ephedrae 600g Ramulus Cinnamomi 450g Herba Schizonepetae 450g Radix Saposhnikoviae 300g Radix Angelicae Dahuricae 300g Rhizoma Chuanxiong 300g Rhizoma Acori Graminei 150g Radix Puerariae 450g Herba Menthae 150g Semen Armeniacae Amarum 600g Radix Angelicae Sinensis 300g Radix Scutellariae 600g Radix Platycodonis 300g.
Two. method for making:
Take by weighing each raw material by proportioning raw materials; The full presciption medicine material is 80% ethanol extraction 2 times with 8 times of amounts, 6 times of amount concentration of volume percent, and each 2 hours, merge extractive liquid, was concentrated into that relative density is 1.05 under the 50-60 ℃ of condition; Spray drying, the active component 1200 that promptly gets medicine of the present invention restrains.
Embodiment 3: the preparation Chinese medicine extract
One. prescription:
Rhizoma Et Radix Notopterygii 30g Herba Ephedrae 60g Ramulus Cinnamomi 45g Herba Schizonepetae 45g Radix Saposhnikoviae 30g Radix Angelicae Dahuricae 30g Rhizoma Chuanxiong 30g Rhizoma Acori Graminei 15g Radix Puerariae 45g Herba Menthae 15g Semen Armeniacae Amarum 60g Radix Angelicae Sinensis 30g Radix Scutellariae 60g Radix Platycodonis 30g
Two. method for making:
Take by weighing each raw material by proportioning raw materials; Take by weighing each raw material by proportioning raw materials; The full presciption medicine material is 75% ethanol extraction 3 times with 10 times of amounts, 8 times of amounts and 6 times of amount concentration of volume percent, and each 1 hour, merge extractive liquid, was concentrated into that relative density is 1.10 under the 50-60 ℃ of condition; Drying under reduced pressure, the active component 143 that promptly gets medicine of the present invention restrains.
Embodiment 4: the preparation Chinese medicine extract
One. prescription:
Rhizoma Et Radix Notopterygii 30g Herba Ephedrae 60g Ramulus Cinnamomi 45g Herba Schizonepetae 45g Radix Saposhnikoviae 30g Radix Angelicae Dahuricae 30g Rhizoma Chuanxiong 30g Rhizoma Acori Graminei 15g Radix Puerariae 45g Herba Menthae 15g Semen Armeniacae Amarum 60g Radix Angelicae Sinensis 30g Radix Scutellariae 60g Radix Platycodonis 30g
Two. method for making:
Take by weighing each raw material by proportioning raw materials; The full presciption medicine material is 66% ethanol extraction 2 times with 10 times of amount concentration of volume percent, and each 1.5 hours, merge extractive liquid, was concentrated into that relative density is 1.08 under the 50-60 ℃ of condition; Spray drying, the active component 152 that promptly gets medicine of the present invention restrains.
Embodiment 5: the preparation Chinese medicine extract
One. prescription:
Rhizoma Et Radix Notopterygii 30g Herba Ephedrae 60g Ramulus Cinnamomi 45g Herba Schizonepetae 45g Radix Saposhnikoviae 30g Radix Angelicae Dahuricae 30g Rhizoma Chuanxiong 30g Rhizoma Acori Graminei 15g Radix Puerariae 45g Herba Menthae 15g Semen Armeniacae Amarum 60g Radix Angelicae Sinensis 30g Radix Scutellariae 60g Radix Platycodonis 30g
Two. method for making:
Take by weighing each raw material by proportioning raw materials; The full presciption medicine material is 70% ethanol extraction 3 times with 6 times of amount concentration of volume percent, and each 3 hours, merge extractive liquid, was concentrated into that relative density is 1.06 under the 50-60 ℃ of condition; Spray drying, the active component 157 that promptly gets medicine of the present invention restrains.
Embodiment 6: the preparation Chinese medicine extract
One. prescription:
Rhizoma Et Radix Notopterygii 30g Herba Ephedrae 60g Ramulus Cinnamomi 45g Herba Schizonepetae 45g Radix Saposhnikoviae 30g Radix Angelicae Dahuricae 30g Rhizoma Chuanxiong 30g Rhizoma Acori Graminei 15g Radix Puerariae 45g Herba Menthae 15g Semen Armeniacae Amarum 60g Radix Angelicae Sinensis 30g Radix Scutellariae 60g Radix Platycodonis 30g
Two. method for making:
Take by weighing each raw material by proportioning raw materials; The full presciption medicine material is 80% ethanol extraction 2 times with 10 times of amount concentration of volume percent, and each 2.5 hours, merge extractive liquid, was concentrated into that relative density is 1.03 under the 50-60 ℃ of condition; Drying under reduced pressure, the active component 138 that promptly gets medicine of the present invention restrains.
Embodiment 7: the preparation Chinese medicine extract
One. prescription:
Rhizoma Et Radix Notopterygii 30g Herba Ephedrae 60g Ramulus Cinnamomi 45g Herba Schizonepetae 45g Radix Saposhnikoviae 30g Radix Angelicae Dahuricae 30g Rhizoma Chuanxiong 30g Rhizoma Acori Graminei 15g Radix Puerariae 45g Herba Menthae 15g Semen Armeniacae Amarum 60g Radix Angelicae Sinensis 30g Radix Scutellariae 60g Radix Platycodonis 30g
Two. method for making:
Take by weighing each raw material by proportioning raw materials; The full presciption medicine material is 70% ethanol extraction 2 times with 8 times of amount concentration of volume percent, and each 2 hours, merge extractive liquid, was concentrated into that relative density is 1.07 under the 50-60 ℃ of condition; Drying under reduced pressure or spray drying, the active component 145 that promptly gets medicine of the present invention restrains.
Embodiment 8: the preparation tablet
The active constituents of medicine 100g that embodiment 1 obtains adds lactose 40g, sodium carboxymethyl cellulose 5g, and tabletting gets tablet, and every is 0.30g.
Embodiment 9: the preparation tablet
The active component 100g that embodiment 2 obtains adds microcrystalline Cellulose 50g, magnesium stearate 5g, and the encapsulating capsule gets capsule, and every is 0.25g.
Embodiment 10: zoopery one: the flu extract causes the influence of rat fever to dry yeast
One. material and method
SD rat male and female half and half, body weight 180～220g
The ICR mice is male, body weight 18～22g
Above laboratory animal provides by Beijing Vital River Experimental Animals Technology Co., Ltd., the quality certification number: SCXK (capital) 2007-0001.
GANMAO RUANJIAONANG (lot number 081129) Tianjin Zhongxin Pharmaceutical Group Co produces
Aspirin effervescent tablets, (lot number 080517) AstraZeneca pharmaceutical Co. Ltd produces
Dry yeast, Hubei Angel Yeast company limited;
Dimethylbenzene, glacial acetic acid are produced by northization glass purchase and sale center, Tianjin
JA1203N type electronic balance, Shanghai Precision Scientific Apparatus Co., Ltd produces
SD rat male and female half and half, use electric body-temperature instrumentation anus temperature 1 time every day before administration, for three days on end, makes rat adapt to operation.Reject the rat of body temperature fluctuation above 0.4 ℃ in three days, test the same day, measure earlier and once select the body temperature of qualified rat as normal body temperature, the dry yeast solution 10ml/kg of subcutaneous injection 20% at once behind the take temperature, the body temperature of the rat of 6h behind the mensuration injection dry yeast is chosen the rat of fervescence value between 0.8～2.0 ℃ and is used for test then.According to the fervescence value rat is divided into 6 groups at random, is respectively model control group, aspirin positive drug group, GANMAO RUANJIAONANG group, the basic, normal, high dosage of flu extract (pressing the preparation of embodiment 1 method), dosage is: model control group is irritated with purified water; Aspirin positive drug group is irritated with 0.3g/kg aspirin medicinal liquid; The GANMAO RUANJIAONANG group is irritated with 7.2g/kg GANMAO RUANJIAONANG medicinal liquid; Flu extract basic, normal, high dosage group is irritated with 1.8,3.6 respectively, 7.2g/kg flu extract medicinal liquid, the administration volume is 10ml/kg, measure the anus temperature of 1h, 2h after the rat administration, 3h and 4h respectively, calculate the difference of itself and normal body temperature, adopt the SPSS11.0 statistics.
Two. result: see Table 1.
Table 1. flu extract causes the influence (x ± s) of rat fever to dry yeast
VS model group * P＜0.05, * * P＜0.01; VS GANMAO RUANJIAONANG group △ P＜0.05
The flu extract all can reduce the rat anus temperature rise that dry yeast causes to some extent 1.8,3.6, under the 7.2g/kg dosage, dose-effect relationship is remarkable, the rat fever that explanation causes dry yeast 1.8,3.6, under the 7.2g/kg dosage at the flu extract, have the trivial solution heat effect, and its refrigeration function of flu extract under the 7.2g/kg dosage is better than the GANMAO RUANJIAONANG with dosage.
Embodiment 11: zoopery two: extract xylol of the present invention causes the influence of mice auricle swelling
One. material and method:
Material is with embodiment 1.
The ICR mice, male, body weight 20～22g is divided into 6 groups at random, is respectively blank group, aspirin positive drug group, GANMAO RUANJIAONANG group, (preparation of embodiment 1 method) basic, normal, high group of flu extract.Dosage is: blank group is irritated with purified water; Aspirin positive drug group is irritated with 0.3g/kg aspirin medicinal liquid; The GANMAO RUANJIAONANG group is irritated with 7.2g/kg GANMAO RUANJIAONANG medicinal liquid; Basic, normal, high group of extract of flu is irritated with 1.8,3.6 respectively, 7.2g/kg flu extract medicinal liquid, the administration volume is 20ml/kg, after the administration 50 minutes, each group all was coated with dimethylbenzene in mice left side ear, and 20 μ l/ only, take off cervical vertebra execution mice after 5 minutes and cut ears, lay round auricle at two ear corresponding sites respectively with 9mm diameter card punch, auris dextra is a normal control, and analytical balance is weighed, calculate swelling degree (every Mus left side auricle heavily deducts the auris dextra sheet and weighs), adopt the SPSS11.0 statistics.
Two. result: see Table 2.
Table 2: flu extract xylol causes the influence (x ± s) of mice auricle swelling
VS blank group * P＜0.05, * * P＜0.01
The flu extract all can reduce dimethylbenzene 1.8,3.6, under the 7.2g/kg dosage and cause the mice auricle swelling degree, illustrate that xylol causes the Mice Auricle inflammation to the flu extract 1.8,3.6, under the 7.2g/kg dosage, have antiinflammation preferably, the flu extract under the 7.2g/kg dosage is with suitable with the GANMAO RUANJIAONANG antiinflammatory action of dosage.
Embodiment 12: zoopery three: extract Dichlorodiphenyl Acetate of the present invention causes the influence of mouse writhing
One. material and method:
Material is with embodiment 1.
The ICR mice, male, body weight 18～22g is divided into 6 groups at random, is respectively basic, normal, high group of blank group, aspirin positive drug group, GANMAO RUANJIAONANG group, flu extract.Dosage is: blank group is irritated with purified water; Aspirin positive drug group is irritated with 0.3g/kg aspirin medicinal liquid; The GANMAO RUANJIAONANG group is irritated with 7.2g/kg GANMAO RUANJIAONANG medicinal liquid; Flu extract (preparation of embodiment 1 method) basic, normal, high group irritated with 1.8,3.6 respectively, 7.2g/kg catches a cold the extract medicinal liquid, the administration volume is 20ml/kg, successive administration 5 days, 1h after the last administration, every mouse peritoneal is injected 0.6% acetic acid, volume is 0.1ml/10g, observes the writhing response in 15 minutes behind every injected in mice acetic acid (abdominal part indent, stretch hind leg, buttocks is raised) number of times, adopts the SPSS11.0 statistics.
Two. result: see Table 3.
The influence of table 3 flu extract Dichlorodiphenyl Acetate initiation mouse writhing (x ± s)
VS blank group * P＜0.05, * * P＜0.01
The flu extract all can reduce acetic acid 3.6, under the 7.2g/kg dosage and cause the mouse writhing number of times, dose-effect relationship is remarkable, illustrate that Dichlorodiphenyl Acetate causes that mice pain turns round body to the flu extract 3.6, under the 7.2g/kg dosage, have analgesic activity preferably, the flu extract under the 7.2g/kg dosage is with suitable with the GANMAO RUANJIAONANG analgesic activity of dosage.
Claims (10)
1. the Chinese medicine composition of a dispeling wind and relieving fever, it is characterized in that: its active component is made by the raw material of following parts by weight: 30 parts of Rhizoma Et Radix Notopterygiis, 60 parts in Herba Ephedrae, 45 parts of Ramulus Cinnamomi, 45 parts of Herba Schizonepetaes, 30 parts of Radix Saposhnikoviaes, 30 parts of the Radixs Angelicae Dahuricae, 30 parts of Rhizoma Chuanxiongs, 15 parts of Rhizoma Acori Graminei, 45 parts of Radix Puerariaes, 15 parts of Herba Menthaes, 60 parts of Semen Armeniacae Amarums, 30 parts of Radix Angelicae Sinensis, 60 parts of Radix Scutellariaes, 30 parts of Radix Platycodoniss.
2. the Chinese medicine composition of a kind of dispeling wind and relieving fever according to claim 1 is characterized in that described active component adopts following method to prepare: take by weighing each raw material by proportioning raw materials; The full presciption medicine material is doubly measured ethanol extraction 2-3 time that concentration of volume percent is 60-80% with 6-10, and each 1-3 hour, merge extractive liquid, was concentrated into that relative density is 1.03-1.10 under the 50-60 ℃ of condition; Drying under reduced pressure or spray drying, promptly.
3. the Chinese medicine composition of a kind of dispeling wind and relieving fever according to claim 2, it is characterized in that: described full presciption medicine material is doubly measured ethanol extraction 2-3 time that concentration of volume percent is 65-75% with 8-10, each 2-3 hour, merge extractive liquid, is concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition; Drying under reduced pressure or spray drying, promptly.
4. the Chinese medicine composition of a kind of dispeling wind and relieving fever according to claim 3, it is characterized in that: described full presciption medicine material is 70% ethanol extraction 2 times with 8 times of amount concentration of volume percent, each 2 hours, merge extractive liquid, was concentrated into that relative density is 1.06-1.08 under the 50-60 ℃ of condition; Drying under reduced pressure or spray drying, promptly.
5. according to the Chinese medicine composition of any one described a kind of dispeling wind and relieving fever in the claim 1 to 4, it is characterized in that: described pharmaceutical composition also contains the pharmaceutics acceptable auxiliary.
6. the Chinese medicine composition of a kind of dispeling wind and relieving fever according to claim 5, it is characterized in that: described pharmaceutics acceptable auxiliary is selected from any one or a few in starch, microcrystalline Cellulose, sucrose, dextrin, lactose, Icing Sugar, glucose, sodium chloride, sodium carboxymethyl cellulose, crospolyvinylpyrrolidone, magnesium stearate, micropowder silica gel, vitamin C, cysteine, citric acid and the sodium sulfite.
7. the Chinese medicine composition of a kind of dispeling wind and relieving fever according to claim 5, it is characterized in that: the dosage form of described Chinese medicine composition is pill, tablet, capsule or oral liquid.
8. the preparation method of the Chinese medicine composition of the described a kind of dispeling wind and relieving fever of claim 1 is characterized in that: take by weighing 30 parts of Rhizoma Et Radix Notopterygiis, 60 parts in Herba Ephedrae, 45 parts of Ramulus Cinnamomi, 45 parts of Herba Schizonepetaes, 30 parts of Radix Saposhnikoviaes, 30 parts of the Radixs Angelicae Dahuricae, 30 parts of Rhizoma Chuanxiongs, 15 parts of Rhizoma Acori Graminei, 45 parts of Radix Puerariaes, 15 parts of Herba Menthaes, 60 parts of Semen Armeniacae Amarums, 30 parts of Radix Angelicae Sinensis, 60 parts of Radix Scutellariaes, 30 parts of Radix Platycodoniss; Take by weighing each raw material by proportioning raw materials; The full presciption medicine material is doubly measured ethanol extraction 2-3 time that concentration of volume percent is 60-80% with 6-10, and each 1-3 hour, merge extractive liquid, was concentrated into that relative density is 1.03-1.10 under the 50-60 ℃ of condition; Drying under reduced pressure or spray drying, promptly.
9. the preparation method of the Chinese medicine composition of a kind of dispeling wind and relieving fever according to claim 8, it is characterized in that: the full presciption medicine material is doubly measured ethanol extraction 2-3 time that concentration of volume percent is 65-75% with 8-10, each 2-3 hour, merge extractive liquid, is concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition; Drying under reduced pressure or spray drying, promptly.
10. the preparation method of the Chinese medicine composition of a kind of dispeling wind and relieving fever according to claim 8, it is characterized in that: the full presciption medicine material is 70% ethanol extraction 2 times with 8 times of amount concentration of volume percent, each 2 hours, merge extractive liquid, was concentrated into that relative density is 1.06-1.08 under the 50-60 ℃ of condition; Drying under reduced pressure or spray drying, promptly.
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| CN104998090A (en) * | 2015-08-25 | 2015-10-28 | 费尔新 | Traditional Chinese medicine for treating infantile fever |
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| CN101757328A (en) * | 2009-09-22 | 2010-06-30 | 贵州健兴药业有限公司 | Cold pill for treating cold and preparation method thereof |
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| CN104998090A (en) * | 2015-08-25 | 2015-10-28 | 费尔新 | Traditional Chinese medicine for treating infantile fever |
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| CN102145092B (en) | 2012-10-31 |
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