CN101757328A - Cold pill for treating cold and preparation method thereof - Google Patents
Cold pill for treating cold and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a cold pill for treating cold and a preparation method thereof. The cold pill is prepared by extracting raw Chinese herbs of notopterygium root, ephedra, cassia twig, schizonepeta spike, ledebouriella root, angelica, hemlock parsley, grassleaved sweetflag, kudzu vine root, mentha haplocalyx, bitter almond, angelica, Baikal skullcap root and platycodon root and then mixing with a ground substance in a certain proportion. The cold pill is a new traditional Chinese medicine excipient for treating cold and a valuable complement to the traditional excipients. Compared with the prior art, the production technique is simple and convenient; and the product has the advantages of convenient control on quality, high stability, high safety, exact curative effect, quick effect, high bioavailability, small size and convenient administration, and can satisfy the demands of patients.
Description
Technical field
The present invention relates to a kind of pharmaceutical preparation for the treatment of flu and preparation method thereof, particularly a kind of cold drop pills for the treatment of flu and preparation method thereof belongs to the technical field of medicine.
Background technology
Flu is a kind of frequently-occurring disease, and its primary symptom shows as aversion to cold, heating, headache, nasal obstruction watery nasal discharge, floating pulse etc., is caused by Respirovirus.GANMAO RUANJIAONANG is the Chinese medicine preparation of the treatment flu of present extensive use clinically, has better therapeutic effect.But the GANMAO RUANJIAONANG onset is slow, and curative effect can not perform to the best, and volume is big, is unfavorable for that the patient takes.
Summary of the invention
Technical problem to be solved by this invention be to provide a kind of rapid-action, bioavailability is high, the cold drop pills of good effect, treatment flu that volume is little, the preparation method of this cold drop pills is provided simultaneously, thereby overcomes the deficiency of existing GANMAO RUANJIAONANG dosage form.
For solving the problems of the technologies described above technical scheme of the present invention: the cold drop pills of treatment flu.It is to comprise Rhizoma Et Radix Notopterygii, Herba Ephedrae, Ramulus Cinnamomi, Herba Schizonepetae, Radix Saposhnikoviae, the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Rhizoma Acori Graminei, Radix Puerariae, Herba Menthae, Semen Armeniacae Amarum, Radix Angelicae Sinensis, Radix Scutellariae and Radix Platycodonis with raw medicinal material, is prepared from a certain proportion of substrate after extracting; Substrate wherein is one or both or the two or more mixture in Polyethylene Glycol (1000～20000), Polysorbate, poloxamer, sodium stearate, glycerin gelatine, the sodium lauryl sulphate; According to listed as parts by weight, the mixed proportion of medicinal substances extract and substrate is a medicinal substances extract: substrate is 1: 1～1: 8.
In the cold drop pills of above-mentioned treatment flu, the weight portion of each raw medicinal material is 82.3 parts of Rhizoma Et Radix Notopterygiis, 164.6 parts in Herba Ephedrae, 123.4 parts of Ramulus Cinnamomi, 123.4 parts of Herba Schizonepetaes, 82.3 parts of Radix Saposhnikoviaes, 82.3 parts of the Radixs Angelicae Dahuricae, 82.3 parts of Rhizoma Chuanxiongs, 41.1 parts of Rhizoma Acori Graminei, 123.4 parts of Radix Puerariaes, 41.1 parts of Herba Menthaes, 164.6 parts of Semen Armeniacae Amarums, 82.3 parts of Radix Angelicae Sinensis, 164.6 parts of Radix Scutellariaes, 82.3 parts of Radix Platycodoniss.
In the cold drop pills of aforesaid treatment flu, used substrate is preferably polyethylene glycol 1500～12000; The mixed proportion of medicinal substances extract and substrate is preferably medicinal substances extract: substrate is 1: 2～1: 4.
In the cold drop pills of aforesaid treatment flu, used substrate is more preferably polyethylene glycol 6000; The mixed proportion of medicinal substances extract and substrate is more preferably medicinal substances extract: substrate is 1: 2.5.
The preparation method of the cold drop pills of treatment flu may further comprise the steps:
(1) Herba Schizonepetae and Herba Menthae were extracted volatile oil 2～4 hours with 8～12 times of water gagings, the leaching medicinal liquid, standby; All the other 12 flavor raw medicinal materials are extracted 2 times with 8～12 times of amount 80% alcohol heating reflux, 1～4 hour for the first time, 1～2 hour for the second time, filter, merging filtrate, recovery ethanol does not extremely have the alcohol flavor, and with the filtrate merging of above-mentioned Herba Schizonepetae and Herba Menthae, the survey relative density is 1.30 thick paste when being concentrated into 50 ℃;
(3) above-mentioned thick paste is added volatile oil, mixing adds Polyethylene Glycol, stirs evenly, and obtains containing the fused solution of drug extract and substrate, and is standby;
(4) the water dropper bore of adjustment drop pill machine, internal diameter is 1～5mm, external diameter is 2～10mm; With the heating of the temperature of dropping-pill machine head and remain on 60 ℃～100 ℃; With condensing agent cooling and remain on 20 ℃～-10 ℃;
(5) the above-mentioned fused solution that contains drug extract and substrate is put into the storage tank of drop pill machine;
(6) fused solution that will contain drug extract and substrate splashes in the condensing agent, is shrunk to ball, promptly.
In the preparation method of the cold drop pills of above-mentioned treatment flu, say accurately that step (1) is that Herba Schizonepetae and Herba Menthae were extracted volatile oil 3 hours with 10 times of water gagings; All the other 12 flavor raw medicinal materials are to extract 2 times with 10 times of amount 80% alcohol heating reflux, and the primary time is 2 hours, and secondary time is 1 hour.
In the preparation method of the cold drop pills of aforesaid treatment flu, say that accurately step is that thick paste is added volatile oil in (3), mixing adds polyethylene glycol 6000.
In the preparation method of the cold drop pills of aforesaid treatment flu, saying accurately, is that the water dropper internal diameter of adjustment drop pill machine is 2mm in the step (4), and external diameter is 5mm; With the heating of the temperature of dropping-pill machine head and remain on 75 ℃; With condensing agent cooling and remain on-5 ℃.
In the preparation method of the cold drop pills of aforesaid treatment flu, the condensing agent in step (4) and the step (6) is preferably liquid Paraffin, perhaps dimethicone, perhaps vegetable oil.
In the preparation method of the cold drop pills of aforesaid treatment flu, the condensing agent in step (4) and the step (6) is more preferably liquid Paraffin.
Beneficial effect of the present invention: cold drop pills of the present invention is a kind of Chinese medicine novel form that is used for the treatment of flu, is a kind of useful of existing dosage form replenished.Compared with prior art, production technology of the present invention is easy, and product quality is convenient to control, and good stability is safe, and the determined curative effect of product simultaneously is rapid-action, bioavailability is high, volume is little, and taking convenience can satisfy the needs of extensive patients.
Each single medical material and pharmacological action thereof are as follows in the prescription of the present invention: Rhizoma Et Radix Notopterygii has the effect of expelling cold and relieving exterior syndrome, wind-damp dispelling, pain relieving.Herba Ephedrae, medicinal ingredient mainly contain L-ephedrine, d-pseudoephedrine, L-a-terpinenol etc., have the effect of diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema, are used for anemofrigid cold, uncomfortable in chestly breath with cough, disease such as bronchial asthma.Ramulus Cinnamomi, medicinal ingredient mainly contain cinnamic aldehyde, beta-elemene, trans isomer cinnamic acid etc., have the effect of diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins, and are used for anemofrigid cold, arthralgia, phlegm retention, edema, cardio palmus.Herba Schizonepetae, medicinal ingredient mainly contain D-menthone, the hot paulownia of 3-, isomenthone etc., have the effect of induce sweat diffusing wind, rash, are used for diseases such as flu, headache, rubella.Radix Saposhnikoviae is used for affection of exogenous wind-cold, headache, disease such as dizzy.The Radix Angelicae Dahuricae has the effect of expelling wind and cold, understand things pain-stopping, detumescence and apocenosis, dampness leukorrhagia stopping, is used for cold, headache, nasal obstruction.Rhizoma Chuanxiong is used for diseases such as air-cooled headache is dizzy, the costalgia abdomen is painful.Rhizoma Acori Graminei, medicinal ingredient mainly contains beta-Asarone etc., has removing dampness, has one's ideas straightened out, the effect of refreshment Fructus Alpiniae Oxyphyllae, is used for diseases such as coma epilepsy, forgetful deafness.Radix Puerariae, medicinal ingredient mainly contain puerarin, cupreol etc., have that spasmolytic is brought down a fever, the effect of yang invigorating pain relieving, are used for diseases such as fever caused by exogenous pathogens headache, stiff nape and back, hypertension neck pain.Herba Menthae, medicinal ingredient mainly contain menthol, menthyl acetate etc., have the effect of dispelling wind-heat, refresh oneself, rash, are used for anemopyretic cold, pathogenic wind-warm from the beginning of diseases such as, headache, conjunctival congestion, sore throat, rubella, breast side of body feeling of distension and oppression.Semen Armeniacae Amarum, medicinal ingredient mainly contain amygdaloside, alpha, beta-lonone etc., have the effect of sending down the abnormal ascending QI relieving cough and asthma, are used for diseases such as cough and asthma, abundant expectoration uncomfortable in chest.Radix Angelicae Sinensis, medicinal ingredient mainly contain nopinene, australene, myrcene etc., and having enriches blood invigorates blood circulation, the effect of relieving spasm to stop pain, are used for diseases such as blood deficiency and yellow complexion, dizzy cardiopalmus, rheumatic arthralgia.Radix Scutellariae, medicinal ingredient mainly contain baicalin, chrysin etc., have the effect of heat clearing and damp drying, eliminating fire and detoxication, hemostasis, are used for diseases such as hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, cough due to lung-heat, hyperpyrexia excessive thirst.Radix Platycodonis, medicinal ingredient mainly contain platycodonin, platycogenic acid A, B, and C etc. have lung qi dispersing, sore-throat relieving, eliminate the phlegm, the effect of evacuation of pus, are used for cough with copious phlegm, smooth, pharyngalgia uncomfortable in chest, hoarseness.Said medicine composition Synergistic, what the product of presenting a memorial to the emperor altogether treatment affection of exogenous wind-cold caused has a headache and fever, the nasal obstruction watery nasal discharge, aversion to cold is lossless, and joint is ached, the remarkable efficacy of laryngopharynx swelling and pain.
Technical study of the present invention is as follows:
1, Study on extraction.
The present invention is on extraction process, and for replenishment of process, alcohol adding amount has carried out following investigation, research during to volatile oil extraction time and each the backflow.
1.1, the determining of volatile oil extraction time
Get Herba Schizonepetae and Herba Menthae 300g crude drug altogether, add 10 times of water gaging distillating extracting oils, certain hour is write down and is put forward oil mass at interval, the results are shown in Table 1.
Table 1
| Time (h) | Put forward oil mass (ml) |
| ????2 | ????1.00 |
| ????2.5 | ????1.05 |
| ????3 | ????1.10 |
| ????3.5 | ????1.10 |
| ????4 | ????1.11 |
As shown in Table 1, extract after 3 hours, the volatilization oil mass is basicly stable, is 3 hours so determine to carry the oil time.
1.2, the extraction processes of 12 flavor medicines such as Rhizoma Et Radix Notopterygii determine
Get 12 flavor crude drug 465g such as Rhizoma Et Radix Notopterygii, totally 3 parts, add 8,10,12 times of amount 80% alcohol heating reflux 2 times, 2 hours for the first time, 1 hour for the second time, filter, merging filtrate reclaims ethanol to there not being the alcohol flavor, is concentrated into thick paste, promptly.Measure Determination of Ephedrine Hydrochloride, the results are shown in Table 2.
Table 2
As shown in Table 2, the ephedrine hydrochloride total amount of 12 times of amount 80% ethanol and 10 times of amount 80% ethanol gained is suitable, than 8 times of amount 80% ethanol height.Take all factors into consideration factors such as reducing ethanol consumption and shortening medicine heated time, it is comparatively suitable that the ethanol consumption is decided to be 10 times of amounts.
According to above result of study: the extraction process of cold drop pills of the present invention is: get Herba Schizonepetae and Herba Menthae and add 10 times of water gagings and extracted volatile oil 3 hours, and the leaching medicinal liquid; 12 flavors such as all the other Rhizoma Et Radix Notopterygiis add 10 times of amount 80% alcohol heating reflux secondaries, and 2 hours for the first time, 1 hour for the second time, filter, merging filtrate reclaims ethanol to there not being the alcohol flavor, merges with above-mentioned filtrate, be concentrated into the thick paste that relative density is about 1.30 (50 ℃), add volatile oil, mixing, promptly.
2, Study on Forming.
Through test, medicinal substances extract and polyethylene glycols and liquid Paraffin or dimethicone or Oleum Arachidis hypogaeae semen all do not have intersolubility, and that polyethylene glycol 6000 drips in the system broken ball than Macrogol 4000 is less, and hardness is good, so determine that polyethylene glycol 6000 is a drop pill substrate, result of the test sees Table 3.
Table 3
According to above intuitive analysis, the liquid Paraffin sedimentation velocity is moderate, and roundness is good, and hardness is good, so the selection liquid Paraffin is a condensing agent.
3, dropping pill technique is preferred
In the preparation technology of drop pill, medicinal substances extract, the mixed proportion of matrix species and substrate is dripped the system temperature, the water dropper bore, coolant temperatures etc. are the key factors of decision drop pill mouldability and presentation quality, on the basis of single factor screening, be substrate with the polyethylene glycol 6000, liquid Paraffin is a condensing agent, (inside/outside mm) is decided to be 2.0/5.0 to the water dropper bore.Medicine and substrate ratio, the factors such as system temperature, coolant temperature of dripping are carried out preferably, the results are shown in Table 4.
Table 4
| Level | Drip the system temperature (℃) | Coolant temperature (℃) | Medicinal liquid: substrate |
| ????1 | ??65 | ????-5 | ????1∶2 |
| ????2 | ??75 | ????0 | ????1∶2.5 |
| ????3 | ??85 | ????5 | ????1∶3 |
Comprehensive above index optimised process collocation obtains the cold drop pills optimised process, and promptly dripping the system temperature is 75 ℃, and coolant temperature is-5 ℃, medicinal substances extract: substrate is 1: 2.5.
The present invention is further illustrated below in conjunction with the specific embodiment.
The specific embodiment
Embodiment 1.Cold drop pills, its prescription is respectively 82.3 parts of 82.3 parts of Rhizoma Et Radix Notopterygiis, 164.6 parts in Herba Ephedrae, 123.4 parts of Ramulus Cinnamomi, 123.4 parts of Herba Schizonepetaes, 82.3 parts of Radix Saposhnikoviaes, 82.3 parts of the Radixs Angelicae Dahuricae, 82.3 parts of Rhizoma Chuanxiongs, 41.1 parts of Rhizoma Acori Graminei, 123.4 parts of Radix Puerariaes, 41.1 parts of Herba Menthaes, 164.6 parts of Semen Armeniacae Amarums, 82.3 parts of Radix Angelicae Sinensis, 164.6 parts of Radix Scutellariaes and Radix Platycodoniss according to listed as parts by weight.By medicinal substances extract: substrate is to carry out proportioning at 1: 2.5.During preparation, Herba Schizonepetae and Herba Menthae were extracted volatile oil 3 hours with 10 times of water gagings, the leaching medicinal liquid; All the other 12 flavor raw material of Chinese medicine extract 2 times with 10 times of amount 80% alcohol heating reflux, and 2 hours for the first time, 1 hour for the second time, filter, merging filtrate reclaims ethanol to there not being the alcohol flavor, merge with above-mentioned Herba Schizonepetae and Herba Menthae filtrate, being concentrated into relative density is the thick paste of 1.30 (50 ℃); Thick paste is added volatile oil, and mixing adds polyethylene glycol 6000, stirs evenly, and the fused solution that obtains containing drug extract and substrate is standby; Adjust the water dropper bore of drop pill machine, internal diameter is 2mm, external diameter 5mm; The temperature heating of dropping-pill machine head also remains on 75 ℃; The condensing agent cooling also remains on-5 ℃; After all reaching requirement in the above-mentioned steps Deng the temperature adjustment of the size adjusting of water dropper internal diameter and external diameter and water dropper and condensing agent, the fused solution that contains drug extract and substrate that obtains is put into the storage tank of drop pill machine; The fused solution of drug extract and substrate is splashed in the liquid Paraffin, be shrunk to ball, make 1000g, promptly.
Embodiment 2.The substrate of preparation is selected Macrogol 4000 for use, and all the other are with embodiment 1.
Embodiment 3.The substrate of preparation is selected poloxamer for use, and all the other are with embodiment 1.
Embodiment 4.Condensing agent is selected Oleum Arachidis hypogaeae semen for use, and all the other are with embodiment 1.
Embodiment 5.Condensing agent is selected dimethicone for use, and all the other are with embodiment 1.
Embodiment 6.Cold drop pills, its prescription is respectively 82.3 parts of 82.3 parts of Rhizoma Et Radix Notopterygiis, 164.6 parts in Herba Ephedrae, 123.4 parts of Ramulus Cinnamomi, 123.4 parts of Herba Schizonepetaes, 82.3 parts of Radix Saposhnikoviaes, 82.3 parts of the Radixs Angelicae Dahuricae, 82.3 parts of Rhizoma Chuanxiongs, 41.1 parts of Rhizoma Acori Graminei, 123.4 parts of Radix Puerariaes, 41.1 parts of Herba Menthaes, 164.6 parts of Semen Armeniacae Amarums, 82.3 parts of Radix Angelicae Sinensis, 164.6 parts of Radix Scutellariaes and Radix Platycodoniss according to listed as parts by weight.By medicinal substances extract: substrate is to carry out proportioning at 1: 2.5.During preparation, Herba Schizonepetae and Herba Menthae were extracted volatile oil 2 hours with 10 times of water gagings, the leaching medicinal liquid; All the other 12 flavor raw material of Chinese medicine extract 2 times with 8 times of amount 80% alcohol heating reflux, and 1 hour for the first time, 1 hour for the second time, filter, merging filtrate reclaims ethanol to there not being the alcohol flavor, merge with Herba Schizonepetae and Herba Menthae filtrate, being concentrated into relative density is the thick paste of 1.30 (50 ℃); Thick paste is added volatile oil, and mixing adds polyethylene glycol 6000, stirs evenly, and the fused solution that obtains containing drug extract and substrate is standby; Adjust the water dropper bore of drop pill machine, internal diameter is 1mm, external diameter 2mm; The temperature heating of dropping-pill machine head also remains on 60 ℃; The condensing agent cooling also remains on-10 ℃; After all reaching requirement in the above-mentioned steps Deng the temperature adjustment of the size adjusting of water dropper internal diameter and external diameter and water dropper and condensing agent, the fused solution that contains drug extract and substrate that obtains is put into the storage tank of drop pill machine; The fused solution of drug extract and substrate is splashed in the liquid Paraffin, be shrunk to ball, make 1000g, promptly.
Embodiment 7.Cold drop pills, its prescription is respectively 82.3 parts of 82.3 parts of Rhizoma Et Radix Notopterygiis, 164.6 parts in Herba Ephedrae, 123.4 parts of Ramulus Cinnamomi, 123.4 parts of Herba Schizonepetaes, 82.3 parts of Radix Saposhnikoviaes, 82.3 parts of the Radixs Angelicae Dahuricae, 82.3 parts of Rhizoma Chuanxiongs, 41.1 parts of Rhizoma Acori Graminei, 123.4 parts of Radix Puerariaes, 41.1 parts of Herba Menthaes, 164.6 parts of Semen Armeniacae Amarums, 82.3 parts of Radix Angelicae Sinensis, 164.6 parts of Radix Scutellariaes and Radix Platycodoniss according to listed as parts by weight.By medicinal substances extract: substrate is to carry out proportioning at 1: 2.5.During preparation, Herba Schizonepetae and Herba Menthae were extracted volatile oil 4 hours with 10 times of water gagings, the leaching medicinal liquid; All the other 12 flavor raw material of Chinese medicine extract 2 times with 12 times of amount alcohol heating reflux, and 4 hours for the first time, 2 hours for the second time, filter, merging filtrate reclaims ethanol to there not being the alcohol flavor, merges with Herba Schizonepetae and Herba Menthae filtrate, and being concentrated into relative density is the thick paste of 1.30 (50 ℃); Thick paste is added volatile oil, and mixing adds polyethylene glycol 6000, stirs evenly, and the fused solution that obtains containing drug extract and substrate is standby; Adjust the water dropper bore of drop pill machine, internal diameter is 5mm, external diameter 10mm; The temperature heating of dropping-pill machine head also remains on 100 ℃; The condensing agent cooling also remains on 20 ℃; After all reaching requirement in the above-mentioned steps Deng the temperature adjustment of the size adjusting of water dropper internal diameter and external diameter and water dropper and condensing agent, the fused solution that contains drug extract and substrate that obtains is put into the storage tank of drop pill machine; The fused solution of drug extract and substrate is splashed in the liquid Paraffin, be shrunk to ball, make 1000g, promptly.
Embodiment 8.Medicinal substances extract: substrate is 1: 2, and all the other are with embodiment 1.
Embodiment 9.Medicinal substances extract: substrate is 1: 4, and all the other are with embodiment 1.
Embodiments of the present invention are not limited to the foregoing description, and the various variations of making under the prerequisite that does not break away from aim of the present invention all belong within protection scope of the present invention.
Claims (10)
1. cold drop pills for the treatment of flu, it is characterized in that: comprise Rhizoma Et Radix Notopterygii, Herba Ephedrae, Ramulus Cinnamomi, Herba Schizonepetae, Radix Saposhnikoviae, the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Rhizoma Acori Graminei, Radix Puerariae, Herba Menthae, Semen Armeniacae Amarum, Radix Angelicae Sinensis, Radix Scutellariae and Radix Platycodonis with raw medicinal material, after extracting, be prepared from a certain proportion of substrate; Substrate wherein is one or both or the two or more mixture in Polyethylene Glycol (1000～20000), Polysorbate, poloxamer, sodium stearate, glycerin gelatine, the sodium lauryl sulphate; According to listed as parts by weight, the mixed proportion of medicinal substances extract and substrate is a medicinal substances extract: substrate is 1: 1～1: 8.
2. the cold drop pills of treatment flu according to claim 1, it is characterized in that: the weight portion of described each raw medicinal material is 82.3 parts of Rhizoma Et Radix Notopterygiis, 164.6 parts in Herba Ephedrae, 123.4 parts of Ramulus Cinnamomi, 123.4 parts of Herba Schizonepetaes, 82.3 parts of Radix Saposhnikoviaes, 82.3 parts of the Radixs Angelicae Dahuricae, 82.3 parts of Rhizoma Chuanxiongs, 41.1 parts of Rhizoma Acori Graminei, 123.4 parts of Radix Puerariaes, 41.1 parts of Herba Menthaes, 164.6 parts of Semen Armeniacae Amarums, 82.3 parts of Radix Angelicae Sinensis, 164.6 parts of Radix Scutellariaes, 82.3 parts of Radix Platycodoniss.
3. the cold drop pills of treatment flu according to claim 1, it is characterized in that: described substrate is polyethylene glycol 1500～12000; The mixed proportion of medicinal substances extract and substrate is a medicinal substances extract: substrate is 1: 2～1: 4.
4. the cold drop pills of treatment flu according to claim 3, it is characterized in that: described substrate is polyethylene glycol 6000; The mixed proportion of medicinal substances extract and substrate is a medicinal substances extract: substrate is 1: 2.5.
5. preparation method as the cold drop pills of any described treatment flu among the claim 1-4 is characterized in that: may further comprise the steps,
(1) Herba Schizonepetae and Herba Menthae were extracted volatile oil 2～4 hours with 8～12 times of water gagings, the leaching medicinal liquid, standby; All the other 12 flavor raw medicinal materials are extracted 2 times with 8～12 times of amount 80% alcohol heating reflux, 1～4 hour for the first time, 1～2 hour for the second time, filter, merging filtrate, recovery ethanol does not extremely have the alcohol flavor, and with the filtrate merging of above-mentioned Herba Schizonepetae and Herba Menthae, the survey relative density is 1.30 thick paste when being concentrated into 50 ℃;
(3) above-mentioned thick paste is added volatile oil, mixing adds Polyethylene Glycol, stirs evenly, and obtains containing the fused solution of drug extract and substrate, and is standby;
(4) the water dropper bore of adjustment drop pill machine, internal diameter is 1～5mm, external diameter is 2～10mm; With the heating of the temperature of dropping-pill machine head and remain on 60 ℃～100 ℃; With condensing agent cooling and remain on 20 ℃～-10 ℃;
(5) the above-mentioned fused solution that contains drug extract and substrate is put into the storage tank of drop pill machine;
(6) fused solution that will contain drug extract and substrate splashes in the condensing agent, is shrunk to ball, promptly.
6. the preparation method of the cold drop pills of treatment flu according to claim 5 is characterized in that: in the described step (1), be that Herba Schizonepetae and Herba Menthae were extracted volatile oil 3 hours with 10 times of water gagings; All the other 12 flavor raw medicinal materials are to extract 2 times with 10 times of amount 80% alcohol heating reflux, and the primary time is 2 hours, and secondary time is 1 hour.
7. the preparation method of the cold drop pills of treatment flu according to claim 5 is characterized in that: in the described step (3), be that thick paste is added volatile oil, mixing adds polyethylene glycol 6000.
8. the preparation method of the cold drop pills of treatment flu according to claim 5 is characterized in that: the water dropper internal diameter that in the described step (4) is adjustment drop pill machine is 2mm, and external diameter is 5mm; With the heating of the temperature of dropping-pill machine head and remain on 75 ℃; With condensing agent cooling and remain on-5 ℃.
9. the preparation method of the cold drop pills of treatment flu according to claim 5, it is characterized in that: the condensing agent in described step (4) and the step (6) is liquid Paraffin or dimethicone or vegetable oil.
10. the preparation method of the cold drop pills of treatment flu according to claim 9, it is characterized in that: the condensing agent in described step (4) and the step (6) is a liquid Paraffin.
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| CN102908516A (en) * | 2012-09-20 | 2013-02-06 | 李承平 | Group of radix polygonati officinalis external-infection pathogenic wind heat tablets |
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| CN107158178A (en) * | 2017-06-27 | 2017-09-15 | 洛阳君山制药有限公司 | A kind of preparation technology of soft capsule for treating common cold |
| CN112587601A (en) * | 2020-12-26 | 2021-04-02 | 贵州健兴药业有限公司 | Improved cold medicine composition and its prepn |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102145092A (en) * | 2010-02-04 | 2011-08-10 | 天津中新药业集团股份有限公司达仁堂制药厂 | Chinese medical composition capable of dispelling wind and relieving fever and preparation method |
| CN102145092B (en) * | 2010-02-04 | 2012-10-31 | 天津中新药业集团股份有限公司达仁堂制药厂 | Chinese medical composition capable of dispelling wind and relieving fever and preparation method |
| CN102600280A (en) * | 2012-03-26 | 2012-07-25 | 许凤霞 | Traditional Chinese medical composition for treatment of pediatric cough |
| CN102908516A (en) * | 2012-09-20 | 2013-02-06 | 李承平 | Group of radix polygonati officinalis external-infection pathogenic wind heat tablets |
| CN106236947A (en) * | 2016-08-30 | 2016-12-21 | 范月娟 | A kind of common cold treatment medicament and production method thereof |
| CN107158178A (en) * | 2017-06-27 | 2017-09-15 | 洛阳君山制药有限公司 | A kind of preparation technology of soft capsule for treating common cold |
| CN112587601A (en) * | 2020-12-26 | 2021-04-02 | 贵州健兴药业有限公司 | Improved cold medicine composition and its prepn |
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