CN101829191A - Expellin extract pill for treating headache and preparation method thereof - Google Patents
Expellin extract pill for treating headache and preparation method thereof Download PDFInfo
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Abstract
The invention discloses an expellin extract pill for treating headache and a preparation method thereof. The expellin extract pill is prepared from medicinal material extracts obtained by extracting crude medicinal materials comprising rhizome Chuanxiong, angelica roots, notopterygium roots, asarum, radices sileris, peppermint and Schizonepeta and a certain proportion of substrates, wherein the substrates are one or two or more than two components of polyethylene glycol (1,000-20,000), polysorbate, poloxamer, sodium stearate, glycerin gelatine and lauryl sodium sulfate. The expellin extract pill is a novel traditional Chinese medicine preparation for treating headache and is beneficial to the replenishment on the traditional expellin extract oral solution dosage forms, has the advantages of simple production process, convenient control of product quality, good stability, high safety, better curative effect, rapid effect, stable quality, good mouth feel, easier acceptance for patients, small size and convenient administration, and can meet different requirements of extensive patients.
Description
Technical field
The present invention relates to a kind of pharmaceutical preparation for the treatment of headache and preparation method thereof, particularly a kind of Expellin extract pill for the treatment of headache and preparation method thereof belongs to the technical field of medicine.
Background technology
Ailment said due to cold or exposure is attacked outward, on violate the head, light gas is hindered, stagnation of QI and blood may bring about pain so its primary symptom shows as headache, can doublely see that also aversion to cold, heating etc. show disease, is more common and the disease that is difficult to cure.The Chuan Xiong Tea oral liquid is the Chinese medicine preparation of the treatment ailment said due to cold or exposure headache of present extensive use clinically, has better therapeutic effect, but Chuan Xiong Tea oral liquid quality is stable inadequately, and mouthfeel is relatively poor, and the patient is difficult for accepting.
Summary of the invention
Technical problem to be solved by this invention is to provide the Expellin extract pill of a kind of rapid-action, steady quality and the easier treatment headache of being accepted by the patient, the preparation method of this Expellin extract pill is provided simultaneously, thereby overcomes the deficiency of existing Chuan Xiong Tea oral liquid formulation.
For solving the problems of the technologies described above technical scheme of the present invention: the Expellin extract pill of treatment headache.Be to be prepared from medicinal substances extract and a certain proportion of substrate that raw medicinal material Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Rhizoma Et Radix Notopterygii, Herba Asari, Radix Saposhnikoviae, Herba Menthae, Herba Schizonepetae and Radix Glycyrrhizae obtain after extracting; Substrate wherein is one or both or the two or more mixture in Polyethylene Glycol (1000～20000), Polysorbate, poloxamer, sodium stearate, glycerin gelatine, the sodium lauryl sulphate; According to listed as parts by weight, the mixed proportion of medicinal substances extract and substrate is a medicinal substances extract: substrate is 1: 1～1: 8.
In the Expellin extract pill of above-mentioned treatment headache, the weight portion of each raw medicinal material is preferably: 244.8 parts of Rhizoma Chuanxiongs, 122.4 parts of the Radixs Angelicae Dahuricae, 122.4 parts of Rhizoma Et Radix Notopterygiis, 61.2 parts of Herba Asaris, 91.8 parts of Radix Saposhnikoviaes, 489.6 parts of Herba Menthaes, 244.8 parts of Herba Schizonepetae, 122.4 parts in Radix Glycyrrhizae.
In the Expellin extract pill of aforesaid treatment headache, described substrate is preferably polyethylene glycol 1500～12000, and the mixed proportion of medicinal substances extract and substrate is preferably medicinal substances extract: substrate is 1: 2～1: 4.
In the Expellin extract pill of aforesaid treatment headache, described substrate is more preferably polyethylene glycol 6000, and the mixed proportion of medicinal substances extract and substrate is more preferably medicinal substances extract: substrate is 1: 2.5.
The preparation method of the Expellin extract pill of treatment headache.May further comprise the steps,
(1) Rhizoma Chuanxiong, Rhizoma Et Radix Notopterygii, Herba Asari, Radix Saposhnikoviae, Herba Menthae, Herba Schizonepetae were extracted volatile oil 2～4 hours with vapor distillation, and the aqueous solution after distillation device is in addition collected; The medicinal residues and the Radix Angelicae Dahuricae, Radix Glycyrrhizae are boiled 2 times with the decocting of 8～12 times of amounts, and 1.5～2.5 hours for the first time, 1.5～2.5 hours for the second time, collecting decoction filters, and adds the aqueous solution after the above-mentioned distillation, the survey relative density is 1.10～1.20 clear paste when being concentrated into 70 ℃, is cooled to room temperature;
(2) concentrated solution adds ethanol and makes and contain alcohol amount and reach 70%, stirs evenly, and supernatant is drawn in cold preservation 24 hours, reclaims ethanol, surveys relative density when being evaporated to 50 ℃ and be 1.25～1.30 thick paste;
(3) taking polyethylene glycol heating and melting adds above-mentioned thick paste, volatile oil successively, stirs evenly, and obtains containing the fused solution of medicinal substances extract and substrate, and is standby;
(4) the water dropper bore of adjustment drop pill machine, internal diameter is 1～5mm, external diameter 2～10mm; The temperature heating of dropping-pill machine head also remains on 60 ℃～100 ℃; The condensing agent cooling also remains on 20 ℃～-10 ℃;
(5) the above-mentioned fused solution that contains medicinal substances extract and substrate that obtains is put into the storage tank of drop pill machine;
(6) fused solution with medicinal substances extract and substrate splashes in the condensing agent, is shrunk to ball, promptly.
In the preparation method of the Expellin extract pill of above-mentioned treatment headache, the time of extracting volatile oil in the described step (1) is more preferably 3 hours; The decocting that the medicinal residues and the Radix Angelicae Dahuricae, Radix Glycyrrhizae are more preferably with 10 times of amounts boils 2 times, and the primary time is 2 hours, and secondary time is 2 hours.
In the preparation method of the Expellin extract pill of aforesaid treatment headache, the Polyethylene Glycol described in the step (3) is more preferably polyethylene glycol 6000.
In the preparation method of the Expellin extract pill of aforesaid treatment headache, adjust the water dropper bore of drop pill machine in the described step (4), internal diameter is 2mm, and external diameter is 5mm; The temperature heating of water dropper machine water dropper also remains on 70 ℃; The condensing agent cooling also remains on-5 ℃.
In the preparation method of the Expellin extract pill of aforesaid treatment headache, the condensing agent described in step (4) and the step (6) is preferably liquid Paraffin or dimethicone or vegetable oil.
In the preparation method of the Expellin extract pill of aforesaid treatment headache, the condensing agent described in step (4) and the step (6) is more preferably liquid Paraffin.
Beneficial effect of the present invention: Expellin extract pill of the present invention is a kind of Chinese medicine novel form that is used for the treatment of headache, is a kind of useful of existing Chuan Xiong Tea oral liquid formulation replenished.Compared with prior art, production technology of the present invention is easy, and product quality is convenient to control, and good stability is safe.Expellin extract pill better efficacy of the present invention, rapid-action, steady quality and mouthfeel is good, patient Geng Yi accepts, its volume is little simultaneously, and taking convenience can satisfy the different needs of extensive patients.
Each single medicinal material and pharmacological action thereof are as follows in the pharmaceutical formulation of the present invention: Rhizoma Chuanxiong is used for diseases such as air-cooled headache is dizzy, the costalgia abdomen is painful.The Radix Angelicae Dahuricae has the effect of expelling wind and cold, understand things pain-stopping, detumescence and apocenosis, dampness leukorrhagia stopping, is used for cold, headache, nasal obstruction.Rhizoma Et Radix Notopterygii has the effect of expelling cold and relieving exterior syndrome, wind-damp dispelling, pain relieving.Herba Asari has expelling wind and cold, understand things pain-stopping, and the effect of warming the lung to resolve fluid-retention is used for anemofrigid cold, headache, toothache, nasal obstruction nasal sinusitis, rheumatic arthralgia, phlegm retention is breathed with cough.Radix Saposhnikoviae is used for affection of exogenous wind-cold, headache, disease such as dizzy.Herba Menthae, medicinal ingredient mainly contain menthol, menthyl acetate etc., have the effect of dispelling wind-heat, refresh oneself, rash, are used for anemopyretic cold, pathogenic wind-warm from the beginning of diseases such as, headache, conjunctival congestion, sore throat, rubella, breast side of body feeling of distension and oppression.Herba Schizonepetae has the diffusing wind that induces sweat, the effect of rash, be used for the flu, the headache, measles, rubella, skin infection from the beginning of.Radix Glycyrrhizae has the gastrointestinal smooth muscular spasm of alleviation and the effect of desoxycortone sample, is used for bronchitis, pharyngolaryngitis, bronchial asthma, chronic adrenocortical hypofunction.
Said medicine composition Synergistic, the product of presenting a memorial to the emperor altogether treatment ailment said due to cold or exposure is had a headache, or the remarkable efficacy of aversion to cold, heating, nasal obstruction is arranged.
Technical study of the present invention is as follows:
1, Study on extraction.
The present invention is on extraction process, and for replenishment of process, the amount of water during to volatile oil extraction time and each the decoction has carried out following investigation, research.
1.1, the determining of volatile oil extraction time.
Take by weighing Rhizoma Chuanxiong 240g, Rhizoma Et Radix Notopterygii 120g, Herba Asari 60g, Radix Saposhnikoviae 90g, Herba Menthae 480g, Herba Schizonepetae 240g add 10 times of water gagings and soaked 1 hour, heating extraction volatile oil is measured extraction time and volatile oil quantitative change situation, the results are shown in Table 1.
Table 1
| Extraction time (h) | Volatilization oil mass (ml) |
| ??2 | ??4.6 |
| ??2.5 | ??5.0 |
| ??3 | ??5.3 |
| ??3.5 | ??5.4 |
| ??4 | ??5.4 |
As shown in Table 1, distill after 3 hours, the volatilization oil mass is basicly stable, is 3 hours so determine to carry the oil time.
1.2, the extraction processes of eight flavor medicines such as Rhizoma Chuanxiong determine.
Get totally 9 parts of Six-element medical materials such as Rhizoma Chuanxiong, divide and you can well imagine oil 3 hours, medicinal residues and the Radix Angelicae Dahuricae, Radix Glycyrrhizae merge, and press amount of water that table 2 stipulates and decocting time decoction 2 times, and collecting decoction is condensed into thick paste, promptly.Measure the content of glycyrrhizic acid, the results are shown in Table 2.
Table 2
As shown in Table 2, with regard to decocting time, 2.5h and 2h carry glycyrrhizic acid amount basically identical, than 1.5h content height; With regard to amount of water, 12 times of amounts and 10 times of amount glycyrrhizic acids of carrying are approaching, and are higher than 8 times of amounts, take all factors into consideration cost factor and reduce the medicine heated time, and it is comparatively suitable to select to add 10 times of water gagings decoction 2h.
According to above result of study, determine that the extraction process of Expellin extract pill is: get Rhizoma Chuanxiong, Rhizoma Et Radix Notopterygii, Herba Asari, Radix Saposhnikoviae, Herba Menthae, Herba Schizonepetae and extracted volatile oil 3 hours with vapor distillation, the aqueous solution after distillation device is in addition collected; The medicinal residues and the Radix Angelicae Dahuricae, Radix Glycyrrhizae are boiled 2 times with the decocting of 10 times of amounts, and 2 hours for the first time, 2 hours for the second time, collecting decoction filtered, and adds the aqueous solution after distilling, and being concentrated into relative density is the clear paste of 1.10～1.20 (70 ℃), is cooled to room temperature.Concentrated solution adds ethanol to be made and contains alcohol amount and reach 70%, stirs evenly, and supernatant is drawn in cold preservation 24 hours, reclaims ethanol, and being evaporated to relative density is the thick paste of 1.25～1.30 (50 ℃), promptly.
2, Study on Forming.
Through test, medicine and polyethylene glycols and liquid Paraffin or dimethicone or Oleum Arachidis hypogaeae semen all do not have intersolubility, and that polyethylene glycol 6000 drips in the system broken ball than Macrogol 4000 is less, and hardness is good, so definite polyethylene glycol 6000 is a drop pill substrate.Result of the test sees Table 3.
Table 3
According to above intuitive analysis, the liquid Paraffin sedimentation velocity is moderate, and roundness is good, and hardness is good, so the selection liquid Paraffin is a condensing agent.
3, dropping pill technique is preferred
In the preparation technology of drop pill, medicinal substances extract, the mixed proportion of matrix species and substrate is dripped the system temperature, the water dropper bore, coolant temperatures etc. are the key factors of decision drop pill mouldability and presentation quality, on the basis of single factor screening, be substrate with the polyethylene glycol 6000, liquid Paraffin is a condensing agent, (inside/outside mm) is decided to be 2.0/5.0 to the water dropper bore.Medicine and substrate ratio, the factors such as system temperature, coolant temperature of dripping are carried out preferably.The results are shown in Table 4.
Table 4 factor level table
Comprehensive above index optimised process collocation obtains the Expellin extract pill optimised process, and promptly dripping the system temperature is 70 ℃, and coolant temperature is 5 ℃, medicinal substances extract: substrate is 1: 2.5.
The present invention is further illustrated below in conjunction with the specific embodiment.
The specific embodiment
Embodiment 1.Expellin extract pill, its prescription is respectively 244.8 parts of Rhizoma Chuanxiongs, 122.4 parts of the Radixs Angelicae Dahuricae, 122.4 parts of Rhizoma Et Radix Notopterygiis, 61.2 parts of Herba Asaris, 91.8 parts of Radix Saposhnikoviaes, 489.6 parts of Herba Menthaes, 244.8 parts of Herba Schizonepetae, 122.4 parts in Radix Glycyrrhizae according to listed as parts by weight.By medicinal substances extract: substrate is to carry out proportioning at 1: 2.5.During preparation, Rhizoma Chuanxiong, Rhizoma Et Radix Notopterygii, Herba Asari, Radix Saposhnikoviae, Herba Menthae, Herba Schizonepetae were extracted volatile oil 3 hours with vapor distillation, the aqueous solution after distillation device is in addition collected; The medicinal residues and the Radix Angelicae Dahuricae, Radix Glycyrrhizae are boiled 2 times with the decocting of 10 times of amounts, and 2 hours for the first time, 2 hours for the second time, collecting decoction filtered, and adds the aqueous solution after distilling, and being concentrated into relative density is the clear paste of 1.10～1.20 (70 ℃), is cooled to room temperature.Concentrated solution adds ethanol to be made and contains alcohol amount and reach 70%, stirs evenly, and supernatant is drawn in cold preservation 24 hours, reclaims ethanol, and being evaporated to relative density is the thick paste of 1.25～1.30 (50 ℃).Taking polyethylene glycol 6000 heating and meltings add above-mentioned thick paste, volatile oil successively, stir evenly, and obtain containing the fused solution of medicinal substances extract and substrate, and are standby.Adjust the water dropper bore of drop pill machine, internal diameter is 2mm, and external diameter is 5mm; The temperature heating of dropping-pill machine head also remains on 70 ℃; The condensing agent cooling also remains on 5 ℃.After all reaching requirement in the above-mentioned steps Deng the temperature adjustment of the size adjusting of water dropper internal diameter and external diameter and water dropper and condensing agent, the storage tank of the fused solution that contains medicinal substances extract and substrate that obtains being put into the drop pill machine splashes into condensing agent with the fused solution of medicinal substances extract and substrate, be shrunk to ball, make 1000g, promptly get Expellin extract pill of the present invention.
Embodiment 2.Substrate is selected Macrogol 4000 for use, and all the other are with embodiment 1.
Embodiment 3.Substrate is selected poloxamer for use, and all the other are with embodiment 1.
Embodiment 4.Condensing agent is selected Oleum Arachidis hypogaeae semen for use, and all the other are with embodiment 1.
Embodiment 5.Condensing agent is selected dimethicone for use, and all the other are with embodiment 1.
Embodiment 6.Expellin extract pill, its prescription is respectively 244.8 parts of Rhizoma Chuanxiongs, 122.4 parts of the Radixs Angelicae Dahuricae, 122.4 parts of Rhizoma Et Radix Notopterygiis, 61.2 parts of Herba Asaris, 91.8 parts of Radix Saposhnikoviaes, 489.6 parts of Herba Menthaes, 244.8 parts of Herba Schizonepetae, 122.4 parts in Radix Glycyrrhizae according to listed as parts by weight.By medicinal substances extract: substrate is to carry out proportioning at 1: 2.5.During preparation, Rhizoma Chuanxiong, Rhizoma Et Radix Notopterygii, Herba Asari, Radix Saposhnikoviae, Herba Menthae, Herba Schizonepetae were extracted volatile oil 2 hours with vapor distillation, the aqueous solution after distillation device is in addition collected.The medicinal residues and the Radix Angelicae Dahuricae, Radix Glycyrrhizae are boiled 2 times with the decocting of 8 times of amounts, and 1.5 hours for the first time, 1.5 hours for the second time, collecting decoction filtered, and adds the aqueous solution after distilling, and being concentrated into relative density is the clear paste of 1.10～1.20 (70 ℃), is cooled to room temperature.Concentrated solution adds ethanol to be made and contains alcohol amount and reach 70%, stirs evenly, and supernatant is drawn in cold preservation 24 hours, reclaims ethanol, and being evaporated to relative density is the thick paste of 1.25～1.30 (50 ℃).Taking polyethylene glycol 6000 heating and meltings add above-mentioned thick paste, volatile oil successively, stir evenly, and the fused solution that obtains containing medicinal substances extract and substrate is standby.Adjust the water dropper bore of drop pill machine, internal diameter is 1mm, and external diameter is 2mm; The temperature heating of dropping-pill machine head also remains on 60 ℃; The condensing agent cooling also remains on 10 ℃.After all reaching requirement in the above-mentioned steps Deng the temperature adjustment of the size adjusting of water dropper internal diameter and external diameter and water dropper and condensing agent, the storage tank of the fused solution that contains medicinal substances extract and substrate that obtains being put into the drop pill machine splashes into condensing agent with the fused solution of medicinal substances extract and substrate, be shrunk to ball, make 1000g, promptly get Expellin extract pill of the present invention.
Embodiment 7.Expellin extract pill, its prescription is respectively 244.8 parts of Rhizoma Chuanxiongs, 122.4 parts of the Radixs Angelicae Dahuricae, 122.4 parts of Rhizoma Et Radix Notopterygiis, 61.2 parts of Herba Asaris, 91.8 parts of Radix Saposhnikoviaes, 489.6 parts of Herba Menthaes, 244.8 parts of Herba Schizonepetae, 122.4 parts in Radix Glycyrrhizae according to listed as parts by weight.By medicinal substances extract: substrate is to carry out proportioning at 1: 2.5.During preparation, Rhizoma Chuanxiong, Rhizoma Et Radix Notopterygii, Herba Asari, Radix Saposhnikoviae, Herba Menthae, Herba Schizonepetae were extracted volatile oil 4 hours with vapor distillation, the aqueous solution after distillation device is in addition collected.The medicinal residues and the Radix Angelicae Dahuricae, Radix Glycyrrhizae are boiled 2 times with the decocting of 10 times of amounts, and 2.5 hours for the first time, 2.5 hours for the second time, collecting decoction filtered, and adds the aqueous solution after distilling, and being concentrated into relative density is the clear paste of 1.10～1.20 (70 ℃), is cooled to room temperature.Concentrated solution adds ethanol to be made and contains alcohol amount and reach 70%, stirs evenly, and supernatant is drawn in cold preservation 24 hours, reclaims ethanol, and being evaporated to relative density is the thick paste of 1.25～1.30 (50 ℃).Taking polyethylene glycol 6000 heating and meltings add above-mentioned thick paste, volatile oil successively, stir evenly, and the fused solution that obtains containing medicinal substances extract and substrate is standby.Adjust the water dropper bore of drop pill machine, internal diameter is 5mm, and external diameter is 10mm; The temperature heating of dropping-pill machine head also remains on 100 ℃; The condensing agent cooling also remains on 20 ℃.After all reaching requirement in the above-mentioned steps Deng the temperature adjustment of the size adjusting of water dropper internal diameter and external diameter and water dropper and condensing agent, the storage tank of the fused solution that contains medicinal substances extract and substrate that obtains being put into the drop pill machine splashes into condensing agent with the fused solution of medicinal substances extract and substrate, be shrunk to ball, make 1000g, promptly get Expellin extract pill of the present invention.
Embodiment 8.By medicinal substances extract: substrate is 1: 2 proportioning, and all the other are with embodiment 1.
Embodiment 9.By medicinal substances extract: substrate is 1: 4 proportioning, and all the other are with embodiment 1.
Embodiments of the present invention are not limited to the foregoing description, and the various variations of making under the prerequisite that does not break away from aim of the present invention all belong within protection scope of the present invention.
Claims (10)
1. Expellin extract pill for the treatment of headache is characterized in that: the medicinal substances extract and a certain proportion of substrate that obtain after extracting with raw medicinal material Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Rhizoma Et Radix Notopterygii, Herba Asari, Radix Saposhnikoviae, Herba Menthae, Herba Schizonepetae and Radix Glycyrrhizae are prepared from; Substrate wherein is one or both or the two or more mixture in Polyethylene Glycol (1000～20000), Polysorbate, poloxamer, sodium stearate, glycerin gelatine, the sodium lauryl sulphate; According to listed as parts by weight, the mixed proportion of medicinal substances extract and substrate is a medicinal substances extract: substrate is 1: 1～1: 8.
2. the Expellin extract pill of treatment headache according to claim 1, it is characterized in that: the weight portion of each raw medicinal material is 244.8 parts of Rhizoma Chuanxiongs, 122.4 parts of the Radixs Angelicae Dahuricae, 122.4 parts of Rhizoma Et Radix Notopterygiis, 61.2 parts of Herba Asaris, 91.8 parts of Radix Saposhnikoviaes, 489.6 parts of Herba Menthaes, 244.8 parts of Herba Schizonepetae, 122.4 parts in Radix Glycyrrhizae.
3. the Expellin extract pill of treatment headache according to claim 1, it is characterized in that: described substrate is polyethylene glycol 1500～12000, and the mixed proportion of medicinal substances extract and substrate is a medicinal substances extract: substrate is 1: 2～1: 4.
4. the Expellin extract pill of treatment headache according to claim 3, it is characterized in that: described substrate is polyethylene glycol 6000, the mixed proportion of medicinal substances extract and substrate is a medicinal substances extract: substrate is 1: 2.5.
5. preparation method as the Expellin extract pill of any described treatment headache among the claim 1-4 is characterized in that: may further comprise the steps,
(1) Rhizoma Chuanxiong, Rhizoma Et Radix Notopterygii, Herba Asari, Radix Saposhnikoviae, Herba Menthae, Herba Schizonepetae were extracted volatile oil 2～4 hours with vapor distillation, and the aqueous solution after distillation device is in addition collected; The medicinal residues and the Radix Angelicae Dahuricae, Radix Glycyrrhizae are boiled 2 times with the decocting of 8～12 times of amounts, and 1.5～2.5 hours for the first time, 1.5～2.5 hours for the second time, collecting decoction filters, and adds the aqueous solution after the above-mentioned distillation, the survey relative density is 1.10～1.20 clear paste when being concentrated into 70 ℃, is cooled to room temperature;
(2) concentrated solution adds ethanol and makes and contain alcohol amount and reach 70%, stirs evenly, and supernatant is drawn in cold preservation 24 hours, reclaims ethanol, surveys relative density when being evaporated to 50 ℃ and be 1.25～1.30 thick paste;
(3) taking polyethylene glycol heating and melting adds above-mentioned thick paste, volatile oil successively, stirs evenly, and obtains containing the fused solution of medicinal substances extract and substrate, and is standby;
(4) the water dropper bore of adjustment drop pill machine, internal diameter is 1～5mm, external diameter 2～10mm; The temperature heating of dropping-pill machine head also remains on 60 ℃～100 ℃; The condensing agent cooling also remains on 20 ℃～-10 ℃;
(5) the above-mentioned fused solution that contains medicinal substances extract and substrate that obtains is put into the storage tank of drop pill machine;
(6) fused solution with medicinal substances extract and substrate splashes in the condensing agent, is shrunk to ball, promptly.
6. the preparation method of the Expellin extract pill of treatment headache according to claim 5 is characterized in that: the time of extracting volatile oil in the described step (1) is 3 hours; The medicinal residues and the Radix Angelicae Dahuricae, Radix Glycyrrhizae are that the decocting with 10 times of amounts boils 2 times, and the primary time is 2 hours, and secondary time is 2 hours.
7. the preparation method of the Expellin extract pill of treatment headache according to claim 5, it is characterized in that: the Polyethylene Glycol described in the step (3) is a polyethylene glycol 6000.
8. the preparation method of the Expellin extract pill of treatment headache according to claim 5 is characterized in that: in the described step (4), adjust the water dropper bore of drop pill machine, internal diameter is 2mm, and external diameter is 5mm; The temperature heating of water dropper machine water dropper also remains on 70 ℃; The condensing agent cooling also remains on-5 ℃.
9. the preparation method of the Expellin extract pill of treatment headache according to claim 5, it is characterized in that: in step (4) and the step (6), described condensing agent is liquid Paraffin or dimethicone or vegetable oil.
10. the preparation method of the Expellin extract pill of treatment headache according to claim 9, it is characterized in that: in step (4) and the step (6), described condensing agent is a liquid Paraffin.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102772580A (en) * | 2012-07-16 | 2012-11-14 | 黄平县润发药业农民专业合作社 | Traditional Chinese medicine decoction for treating migraine and preparation method thereof |
| CN103263468A (en) * | 2013-05-30 | 2013-08-28 | 钦州市钦南区人民医院 | Traditional Chinese medicine for treating conjunctivitis |
| CN103816223A (en) * | 2014-02-24 | 2014-05-28 | 贵州威门药业股份有限公司 | Sugar-free Ligusticum wallichii tea-mixed granules |
| CN112494540A (en) * | 2020-12-26 | 2021-03-16 | 贵州健兴药业有限公司 | Preparation method of improved ligusticum wallichii tea-blending pharmaceutical composition |
| CN113552276A (en) * | 2021-07-06 | 2021-10-26 | 贵州健兴药业有限公司 | Detection method of ligusticum wallichii and tea blending dropping pill |
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2009
- 2009-09-22 CN CN200910307436A patent/CN101829191A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102772580A (en) * | 2012-07-16 | 2012-11-14 | 黄平县润发药业农民专业合作社 | Traditional Chinese medicine decoction for treating migraine and preparation method thereof |
| CN103263468A (en) * | 2013-05-30 | 2013-08-28 | 钦州市钦南区人民医院 | Traditional Chinese medicine for treating conjunctivitis |
| CN103816223A (en) * | 2014-02-24 | 2014-05-28 | 贵州威门药业股份有限公司 | Sugar-free Ligusticum wallichii tea-mixed granules |
| CN112494540A (en) * | 2020-12-26 | 2021-03-16 | 贵州健兴药业有限公司 | Preparation method of improved ligusticum wallichii tea-blending pharmaceutical composition |
| CN113552276A (en) * | 2021-07-06 | 2021-10-26 | 贵州健兴药业有限公司 | Detection method of ligusticum wallichii and tea blending dropping pill |
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Application publication date: 20100915 |