The method for preparing of MAIWEI DIHUANG KOUFU ZHIJI
Technical field: the present invention relates to a kind of method for preparing of MAIWEI DIHUANG KOUFU ZHIJI, belong to the field of medicine technology.
Technical background: deficiency of YIN of both the lung and kidney, hectic fever night sweat, the dry pharynx hemoptysis, vertigo and tinnitus, soreness of the waist and knees, quenching one's thirst is clinical common sympton, the means that the traditional Chinese medical science often adopts nourishing kidney to support lung are treated it.Maiwei-dihuang preparation adds foster Radix Ophiopogonis of having both clearly, mends the Fructus Schisandrae Chinensis composition of holding back with tool with the classical name side of the kidney invigorating Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Fructus Corni, Rhizoma Alismatis, Cortex Moutan, Poria.In the side with Radix Rehmanniae Preparata, Radix Ophiopogonis, Rhizoma Dioscoreae, Fructus Corni and the kidney invigorating, lung, spleen, stomach earlier, the day after tomorrow cloudy Tianjin be agent structure; Can ooze again Rhizoma Alismatis, Cortex Moutan, Poria, Radix Ophiopogonis to let out and stay turbid, deficiency-heat due to the deficiency of YIN, with the Fructus Schisandrae Chinensis tonifying YIN of astringing the lung, strengthen the strong effect of yin nourishing benefit again, alleviates dry yearningly, the dry cough disease.All medicines are assisted each other, rule together up and down, and be main with the tonifying the lung kidney, and full side benefit is not stayed turbid.Both be good at removing soreness of the waist and knees due to the deficiency of YIN, vertigo and tinnitus, insomnia forgetfulness, dryness of the intestine constipation, dry pharynx, symptom such as thirsty, and be good at treating the deficiency of YIN again and stay diseases such as hectic fever night sweat, nocturia, dry cough, hemoptysis spitting of blood buccal void due to turbid and the deficiency-heat is red, the few tongue of red tongue.Modern pharmacological research proves that Maiwei-dihuang preparation has blood sugar lowering, blood fat reducing, raising immunity, the anti-ageing effect of waiting for a long time.For diseases such as treatment diabetes, hyperthyroidism, pulmonary tuberculosis, chronic bronchitis, emphysema definite curative effect is arranged.Existing method of producing Maiwei-dihuang preparation generally is to adopt the method for putting down in writing on ministry standard and the Chinese Pharmacopoeia; The method of above-mentioned standard record is fairly simple; Cause containing a large amount of invalid components and impurity in the product, make that the clinical efficacy of Maiwei-dihuang preparation is not ideal enough.
Summary of the invention: technical problem to be solved by this invention is to provide a kind of method for preparing of MAIWEI DIHUANG KOUFU ZHIJI.
For solving the problems of the technologies described above; The present invention adopts following technical scheme to realize: a kind of MAIWEI DIHUANG KOUFU ZHIJI; Calculate according to composition by weight, it Radix Ophiopogonis 30-120, Fructus Schisandrae Chinensis (system) 20-80, Radix Rehmanniae Preparata 80-320, Fructus Corni (system) 40-160, Cortex Moutan 30-120, Rhizoma Dioscoreae 40-160, Poria 30-120, Rhizoma Alismatis 30-120 and adjuvant be prepared from.
Specifically: calculate according to composition by weight, it is prepared from Radix Ophiopogonis 60, Fructus Schisandrae Chinensis (system) 40, Radix Rehmanniae Preparata 160, Fructus Corni (system) 80, Cortex Moutan 60, Rhizoma Dioscoreae 80, Poria 60, Rhizoma Alismatis 60 and adjuvant.
The method for preparing of MAIWEI DIHUANG KOUFU ZHIJI according to the invention is: Radix Ophiopogonis powder is broken into fine powder, the Cortex Moutan pulverize at low temperature becomes fine powder; Fructus Corni, Fructus Schisandrae Chinensis and Rhizoma Alismatis add 5-10 doubly measures, the ethanol extraction of 50-85% 1-3 time, and each 1-5 hour, filter, merge extractive liquid, reclaims ethanol and is condensed into thick paste; Radix Rehmanniae Preparata adds 5-10 times of water gaging with Rhizoma Dioscoreae, Poria again and decocts 1-4 time earlier with boiling water lixiviate 3-8 hour, and each 0.5-3 hour, collecting decoction filtered, and filtrating is condensed into thick paste; Above-mentioned fine powder and thick paste mixing, dry below 60 ℃ and 60 ℃, pulverize, add conventional adjuvant again and can process different oral formulations according to conventional method.
Specifically, the method for preparing of MAIWEI DIHUANG KOUFU ZHIJI according to the invention is: Radix Ophiopogonis powder is broken into 80 purpose fine powders, the Cortex Moutan pulverize at low temperature becomes 80 purpose fine powders; Fructus Corni, Fructus Schisandrae Chinensis, Rhizoma Alismatis add 8 times of amount 65% ethanol for the first time with 65% ethanol extraction 2 times, add 6 times of amount 65% ethanol for the second time; Each 2 hours, filter merge extractive liquid; Reclaim ethanol, being condensed into when relative density is 80 ℃ is 1.10~1.15 thick pastes; Radix Rehmanniae Preparata is earlier with boiling water lixiviate 5 hours, and again with Rhizoma Dioscoreae, Poria decocte with water three times, each 1 hour, added 10 times of water gagings the first time, and second and third time adds 8 times of water gagings, and collecting decoction filters, and it is 1.10~1.15 thick pastes that filtrating is condensed into when relative density is 80 ℃; Above-mentioned fine powder and thick paste mixing, 60 ℃ of dryings are pulverized, and add conventional adjuvant again and can process different oral formulations according to conventional method.
Said oral formulations is meant capsule, tablet and pill.
Said tablet is meant coated tablet and Film coated tablets.
Specifically: the method for preparing of capsule according to the invention is: Radix Ophiopogonis powder is broken into fine powder, the Cortex Moutan pulverize at low temperature becomes fine powder; Fructus Corni, Fructus Schisandrae Chinensis and Rhizoma Alismatis add 5-10 doubly measures, the ethanol extraction of 50-85% 1-3 time, and each 1-5 hour, filter, merge extractive liquid, reclaims ethanol and is condensed into thick paste; Radix Rehmanniae Preparata adds 5-10 times of water gaging with Rhizoma Dioscoreae, Poria again and decocts 1-4 time earlier with boiling water lixiviate 3-8 hour, and each 0.5-3 hour, collecting decoction filtered, and filtrating is condensed into thick paste; Above-mentioned fine powder and thick paste mixing, dry below 60 ℃ and 60 ℃, pulverize, add 0.5% magnesium stearate, mixing incapsulates, and promptly gets.
The method for preparing of pill according to the invention is: Radix Ophiopogonis powder is broken into fine powder, the Cortex Moutan pulverize at low temperature becomes fine powder; Fructus Corni, Fructus Schisandrae Chinensis and Rhizoma Alismatis add 5-10 doubly measures, the ethanol extraction of 50-85% 1-3 time, and each 1-5 hour, filter, merge extractive liquid, reclaims ethanol and is condensed into thick paste; Radix Rehmanniae Preparata adds 5-10 times of water gaging with Rhizoma Dioscoreae, Poria again and decocts 1-4 time earlier with boiling water lixiviate 3-8 hour, and each 0.5-3 hour, collecting decoction filtered, and filtrating is condensed into thick paste; Above-mentioned fine powder and thick paste mixing, pill, dry below 60 ℃ and 60 ℃, polishing or sugar coating or bag film-coat promptly get pill.
The method for preparing of tablet according to the invention is: Radix Ophiopogonis powder is broken into fine powder, the Cortex Moutan pulverize at low temperature becomes fine powder; Fructus Corni, Fructus Schisandrae Chinensis and Rhizoma Alismatis add 5-10 doubly measures, the ethanol extraction of 50-85% 1-3 time, and each 1-5 hour, filter, merge extractive liquid, reclaims ethanol and is condensed into thick paste; Radix Rehmanniae Preparata adds 5-10 times of water gaging with Rhizoma Dioscoreae, Poria again and decocts 1-4 time earlier with boiling water lixiviate 3-8 hour, and each 0.5-3 hour, collecting decoction filtered, and filtrating is condensed into thick paste; Above-mentioned fine powder and thick paste mixing are processed granule, and be dry below 60 ℃ and 60 ℃, adds dried grain amount 0.5-1% magnesium stearate again, mixing, and tabletting, sugar coating or film-coat promptly get tablet.
In the prescription of Maiwei-dihuang preparation, Cortex Moutan has the effect of clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling, and its main effective ingredient is a paeonol, and paeonol has pharmacological actions such as antiinflammatory, antibacterial, spasmolytic, analgesia, antiallergic and immunomodulating; Because the Cortex Moutan quality is hard, in conventional crushing process, material is at the pulverizer intracavity; Receive between steel-tooth splitting, tear the effect with grinding machinery power, make the bulky grain of medicine become granule, surface area increases; Mechanical energy changes in the surface energy process, and the pulverizer temperature can raise, the corresponding rising of temperature of the Paeonia suffruticosa PIFEN after the pulverizing; And crushing quantity is big more, and temperature is high more.And paeonol is unstable, and the high volatilization easily of temperature causes the content of paeonol to reduce, and finds after the experimentation, is pulverizing Cortex Moutan below 60 ℃ and 60 ℃, can effectively guarantee the content of paeonol.The Radix Rehmanniae Preparata nourishing kidney yin, life essence-filling, marrow-benefitting, warm in nature and mend, cloudy to lose the person suitable, and can solely go into kidney man.Show after deliberation, in the Radix Rehmanniae Preparata water extract, mainly contain effective ingredient such as prepared rehmannia root polysaccharide, the Radix Rehmanniae Preparata water extract has antioxidation, enriches blood, improves effects such as immunity.Radix Rehmanniae Preparata generally is directly to use water extraction in the prior art, but the inventor finds that through experimentation Radix Rehmanniae Preparata soaks earlier before decocting, can improve the yield of Radix Rehmanniae Preparata water extract.The effect that Rhizoma Dioscoreae has spleen invigorating, dehumidifying, QI invigorating, lung benefiting, reinforces the kidney, benefit is smart, its effective ingredient Chinese yam polysaccharide has effects such as enhance immunity, defying age, antioxidation; Poria has eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, the effect of mind tranquilizing and the heart calming, effect such as the main effective ingredient pachyman in the Poria has enhancing immunity, protects the liver, antiviral.Research shows that Rhizoma Dioscoreae and Poria are used water boiling and extraction, with direct comminution ratio, can remove a large amount of impurity, keep simultaneously Chinese yam polysaccharide and pachyman to greatest extent.Fructus Corni has the function of arresting seminal emission, arresting sweating, invigorating the liver and kidney, and its main effective ingredient is compositions such as iridoid glycosides, polysaccharide, organic acid, tannin.Big quantity research shows, Fructus Corni total glycosides has significant rabbit epidemic disease and regulates active and effects such as antiinflammatory, anticancer, blood sugar lowering, heart tonifying, and loganin is a content higher effective composition in the Fructus Corni total glycosides.In the technology of existing Maiwei-dihuang preparation, Fructus Corni adopts water boiling and extraction more, finds that after deliberation Fructus Corni is made extraction solvent with ethanol, can improve the active constituent content of Fructus Corni.Fructus Schisandrae Chinensis has astringes the lung, and nourishing kidney is promoted the production of body fluid, and receives the effect of antiperspirant and arresting seminal emission.Contained schisandrin, schisandrin B are the main effectively active component of Fructus Schisandrae Chinensis retardance hepatocyte injury in the Fructus Schisandrae Chinensis.Research shows that Fructus Schisandrae Chinensis is used ethanol extraction, compares with the water boiling and extraction method, and the content of schisandrin B is higher.Rhizoma Alismatis has diuretic, eliminating dampness by diuresis, the effect that expels the heat-evil.The effective constituent that mainly contains that contained 23-alisol acetyl B is the Rhizoma Alismatis hepatoprotective effect in the Rhizoma Alismatis can be protected the mouse liver because of carbon tetrachloride poisoning.Research shows that Rhizoma Alismatis is used ethanol extraction, has avoided conventional water boiling and extraction, the shortcoming that above effective component extraction rate is low.
Compared with prior art, the present invention adopts the pulverize at low temperature Cortex Moutan, can guarantee the content of paeonol; Before the Radix Rehmanniae Preparata decocting, soak earlier, can improve the yield of Radix Rehmanniae Preparata water extract; The water decocting method extracts Rhizoma Dioscoreae and Poria, with direct comminution ratio, can remove a large amount of impurity, keep the content of its effective ingredient Chinese yam polysaccharide and pachyman simultaneously to greatest extent; Fructus Corni is made extraction solvent with ethanol, can improve content of effective such as loganin; Fructus Schisandrae Chinensis is used ethanol extraction, compares with the water boiling and extraction method, and the content of schisandrin B is higher; Rhizoma Alismatis is used ethanol extraction, when having avoided conventional water boiling and extraction, and the low shortcomings of effective component extraction rate such as 23-alisol acetyl B; Total glycosides in the Fructus Corni is insoluble in water, is soluble in alcohol, adopts ethanol extraction, can improve the extraction ratio of total glycosides, and the present invention detects index.The present invention is according to the character of each medicine in the Maiwei-dihuang preparation, and this medicine role in prescription, and the technology of Maiwei-dihuang preparation is optimized; Make the refine more of this medicine, drug effect is more remarkable, for deficiency of YIN of both the lung and kidney; Hectic fever night sweat; The dry pharynx hemoptysis, vertigo and tinnitus, soreness of the waist and knees etc. have better therapeutical effect.Compare with existing preparation, preparation active constituent content of the present invention is high, and clinical efficacy is good, has reached the purpose of invention.
The applicant has carried out following experiment, and provable the present invention has effective effect;
Experimental example 1: Cortex Moutan breaking method experimentation
Cortex Moutan has the merit of clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling for Maiwei-dihuang capsule prescription Chinese crude drug.The main effective ingredient of Cortex Moutan is a paeonol, has pharmacological actions such as antiinflammatory, antibacterial, spasmolytic, analgesia, antiallergic and immunomodulating.According to production technology, need Cortex Moutan is pulverized, generally adopt dry pulverization process; The applicant gets with a collection of Cortex Moutan medical material through discovering, changes breaking method; Adopt pulverize at low temperature (material mix again pulverize) with liquid nitrogen; Can reduce the loss of effective ingredient paeonol content, can guarantee effective component content, result of the test is following:
1, crude drug (numbering: W-1)
2, dry pulverization process (numbering: W-2): get the 100kg Cortex Moutan, be ground into 80 order fine powders.
3, pulverize at low temperature (numbering: W-3): get the 100kg Cortex Moutan, be ground into 80 order fine powders.
With paeonol content result in batch different grinding mode Cortex Moutans relatively
The result shows: pulverizing below 60 ℃ and 60 ℃, can guarantee the content of paeonol.
Experimental example 2: Fructus Schisandrae Chinensis, Fructus Corni and Rhizoma Alismatis Study on extraction
Preparation process of the present invention: get Fructus Schisandrae Chinensis (system), Fructus Corni (system) and Rhizoma Alismatis with 65% ethanol extraction 2 times; Add for the first time 8 times of amount 65% ethanol (V/V), add 6 times of amount 65% ethanol (V/V) for the second time, each 2 hours; Filter; Merge extractive liquid, reclaims ethanol, and being condensed into relative density is 1.10~1.15 (80 ℃) thick paste;
Former preparation process: get Fructus Schisandrae Chinensis (system), Fructus Corni (system) and Rhizoma Alismatis decocte with water three times, each 1 hour, add 10 times of water gagings for the first time, second and third time adds 8 times of water gagings, and collecting decoction filters, and it is 1.10~1.15 (80 ℃) thick paste that filtrating is condensed into relative density.
Detect the wherein content of schisandrin B, loganin, 23-alisol acetyl B respectively, the result is:
Project |
Preparation process of the present invention |
Former preparation process |
Schisandrin B |
0.30% |
0.13% |
Loganin |
0.79% |
0.48% |
23-alisol acetyl B |
0.56% |
0.25% |
Above experimental result shows that the content of schisandrin B, loganin, 23-alisol acetyl B is higher in the preparation process extract of the present invention, is superior to former preparation process.
Experimental example 3: Radix Rehmanniae Preparata Study on extraction
Preparation process of the present invention: Radix Rehmanniae Preparata is first with boiling water lixiviate 5 hours, decocte with water three times, and each 1 hour, add 10 times of water gagings for the first time, second and third time adds 8 times of water gagings, and collecting decoction filters, and it is 1.10~1.15 (80 ℃) thick paste that filtrating is condensed into relative density.
Former preparation process: Radix Rehmanniae Preparata decocte with water three times, each 1 hour, add 10 times of water gagings for the first time, second and third time adds 8 times of water gagings, and collecting decoction filters, and it is 1.10~1.15 (80 ℃) thick paste that filtrating is condensed into relative density.
Measure the yield of Radix Rehmanniae Preparata water extract respectively, the result is:
Project |
Preparation process yield of the present invention (%) |
Former preparation process yield (%) |
The Radix Rehmanniae Preparata water extract |
72% |
61% |
Above experimental result shows that preparation process extraction ratio of the present invention is higher, is superior to former preparation process.
Experimental example 6: pharmacodynamic study
The applicant has carried out main pharmacodynamics research to the present invention, through experimental data beneficial effect of the present invention is described.
1, extracorporeal bacteria inhibitor test
1.1 test strain
Staphylococcus aureus, Staphylococcus albus, Pseudomonas aeruginosa, escherichia coli, Bacillus proteus, alpha streptococcus, group B streptococcus are all purchased in Nat'l Pharmaceutical & Biological Products Control Institute.
1.2 sample preparation
Former technology extract: the technology according to the 5th (WS3-B-0938-91) record of the Sanitation Ministry medicine standard Chinese traditional patent formulation preparation is processed extract, processes the medicinal liquid of 10% concentration (g/ml) with purified water;
Extract of the present invention: process extract according to the method for the invention, process the medicinal liquid of 10% concentration (g/ml) with purified water;
1.3 medium preparation
1.3.1 ordinary culture medium preparation
Learn from else's experience Nutrient agar behind the autoclaving, every respectively plate 10ml is poured into flat board, promptly gets after solidifying.
1.3.2 blood plate medium preparation
Nutrient agar behind autoclaving when being cooled to 56 ℃ of alpha streptococcuss, group B streptococcus, adds 10% aseptic degreasing fiber Sanguis caprae seu ovis, mixing, and every respectively plate 10ml is poured into flat board, promptly gets after solidifying.
1.4 bacteriostatic test
Respectively with asepsis ring depletion Staphylococcus aureus, Staphylococcus albus, Pseudomonas aeruginosa, escherichia coli, Bacillus proteus respectively densification be inoculated into common Nutrient medium surface.Respectively with asepsis ring get alpha streptococcus, group B streptococcus respectively densification be inoculated into the blood plate media surface.On flat board, punch, the aperture is 5mm.Respectively medicinal liquid is filled it up with in each dull and stereotyped hole, cultivated after 24 hours for 37 ℃, observed result is measured antibacterial circle diameter, gets 6 result of the test averages as antibacterial circle diameter.
1.5 result
Two kinds of extracts all have bacteriostasis (seeing table 1) to staphylococcus aureus, Staphylococcus albus, Pseudomonas aeruginosa, escherichia coli, Bacillus proteus, alpha streptococcus, group B streptococcus, see following table for details.
Table 1 bacteriostatic test result (x ± SD)
Annotate: technology of the present invention and former technology is * P<0.05 relatively
1.6 conclusion
Above experimental studies results shows that preparation of the present invention all has bacteriostasis to staphylococcus aureus, Staphylococcus albus, Pseudomonas aeruginosa, escherichia coli, Bacillus proteus, alpha streptococcus, group B streptococcus, and fungistatic effect is superior to former technology.
2, analgesic test
2.1 experimental technique
Get 48 of healthy Kunming mouses; Male and female half and half; Be divided into 4 groups at random, i.e. normal saline group, preparation group of the present invention (processing extract), former technology preparation group (technology according to the record of ministry standard MAIWEIDIHUANGPIAN is processed extract) and aspirin group, 12 every group according to the method for the invention.Successive administration 4 days, every day 1 time, the normal saline group gives equal-volume normal saline (20ml/kg); All the other groups press respectively 1.28g/Kg (20ml/kg) dosage irritate to obey preparation of the present invention, former technology preparation and aspirin medicinal liquid (0.25g/kg, 20ml/kg), all in last 30min behind medicine; Each mouse peritoneal is only injected 0.8% acetum 0.2ml/; The number of times of writhing response appears in every mice in the observed and recorded 15min, calculates mean and standard deviation, the comparable group differences.
2.2 result
Each administration group all can be resisted the pain reaction due to the acetic acid stimulation, makes the mouse writhing number of times obviously reduce (seeing table 2).
The influence of table 2 pair mouse writhing number of times (n=12, x ± s)
Annotate: preparation group of the present invention and former technology preparation group be * P<0.05 relatively
2.3 conclusion
Above experimental studies results shows that preparation group of the present invention and former technology preparation group all can be resisted the pain reaction due to the acetic acid stimulation; Preparation group wherein of the present invention is superior to former technology preparation group (P<0.05).
3, to deficiency of YIN effect of immunologic function
3.1 hemolytic plaque test: 48 of male mices; Body weight 18~22g; Divide 4 groups at random; Be matched group, model group, preparation group of the present invention (processing extract), former technology preparation group (technology according to the record of ministry standard MAIWEIDIHUANGPIAN is processed extract) according to the method for the invention, 12 every group.Use T
3Method is set up the yin deficiency syndrome animal model.Irritated clothes distilled water or medicine every day 1 time continuous 10 days, and, irritated clothes T in administration beginning in the 6th day
318 μ l/ moulding in only continuous 5 days.In administration in the time of the 6th day, with fresh sheep red blood cell (SRBC) suspension (SR-BC) immunity, every Mus 4 * 10
8RBC/0.5ml ip.After immunity, put to death animal on the 4th day, separation of serum and preparation splenocyte suspension, the plaque number with on every slide of agarose slide method counting calculates cell volume.According to splenocyte concentration correction in cell volume and the mixed liquor per 1,000,000 (1 * 10
6) to contain plaque forming cells's number in the splenocyte (be PFC number/10
6Splenocyte), the blood sample BIAO and BEN is pressed literature method and is detected the serum agglutinin, and the result representes with the log2 titre; Other has experiment to get 60 of mices, and body weight 17~22g with method grouping perfusion, uses T
3Method moulding and immune with fresh SRBC, experiment finish to put to death animal, take blood preparation, and the reference literature method is done the formation of E bow structure and tested, observation E bow structure formation rate, and promptly the erythrocyte Flos Rosae Rugosae forms cell (ERFC) formation rate, and the result sees the following form.
The influence of deficiency of YIN mouse antibodies formation cell (x ± SD)
Annotate: preparation group of the present invention and former technology preparation group be * P<0.05 relatively
3.2 the result shows: preparation group of the present invention and former technology preparation group all can make deficiency of YIN mice plaque forming cells number obviously raise; Make deficiency of YIN mice serum agglutinin return to normal level, increase deficiency of YIN mice E bow structure formation rate.Compare preparation group better effects if of the present invention (P<0.05) with former technology preparation group.
The specific embodiment:
Embodiment 1:
Prescription: Radix Ophiopogonis 60g, Fructus Schisandrae Chinensis (system) 40g, Radix Rehmanniae Preparata 160g, Fructus Corni (system) 80g, Cortex Moutan 60g, Rhizoma Dioscoreae 80g, Poria 60g, Rhizoma Alismatis 60g
Technology: Radix Ophiopogonis powder is broken into 80 purpose fine powders, the Cortex Moutan pulverize at low temperature becomes 80 purpose fine powders; Fructus Corni, Fructus Schisandrae Chinensis, Rhizoma Alismatis add 8 times of amount 65% ethanol for the first time with 65% ethanol extraction 2 times, add 6 times of amount 65% ethanol for the second time; Each 2 hours, filter merge extractive liquid; Reclaim ethanol, being condensed into when relative density is 80 ℃ is 1.10~1.15 thick pastes; Radix Rehmanniae Preparata is earlier with boiling water lixiviate 5 hours, and again with Rhizoma Dioscoreae, Poria decocte with water three times, each 1 hour, added 10 times of water gagings the first time, and second and third time adds 8 times of water gagings, and collecting decoction filters, and it is 1.10~1.15 thick pastes that filtrating is condensed into when relative density is 80 ℃; Above-mentioned fine powder and thick paste mixing, 60 ℃ of dryings are pulverized, and add 0.5% magnesium stearate, and mixing incapsulates, and promptly gets capsule.
Usage and consumption: oral.A 3-4 grain, 3 times on the one.
Embodiment 2:
Prescription: Radix Ophiopogonis 120g, Fructus Schisandrae (processed) 80g, Radix Rehmanniae Preparata 320g, Fructus Corni (processed) 160g, Cortex Moutan 120g, Rhizoma Dioscoreae 160g, Poria 120g, Rhizoma Alismatis 120g
Technology: Radix Ophiopogonis powder is broken into 100 purpose fine powders, the Cortex Moutan pulverize at low temperature becomes 100 purpose fine powders; The ethanol extraction of Fructus Corni, Fructus Schisandrae Chinensis and 10 times of amounts 85% of Rhizoma Alismatis adding 5 hours, extracting solution filters, and reclaims ethanol and also is condensed into the thick paste that relative density is 1.10~1.15 (80 ℃); Radix Rehmanniae Preparata adds 10 times of water gagings with Rhizoma Dioscoreae, Poria again and decocted 3 hours earlier with boiling water lixiviate 8 hours, and decocting liquid filters, and filtrating is condensed into thick paste; Above-mentioned fine powder and thick paste mixing, pill, 50 ℃ of dryings, polishing promptly gets pill.
Usage and consumption: oral.A 3-4 grain, 3 times on the one.
Embodiment 3:
Prescription: Radix Ophiopogonis 30g, Fructus Schisandrae (processed) 20g, Radix Rehmanniae Preparata 80g, Fructus Corni (processed) 40g, Cortex Moutan 30g, Rhizoma Dioscoreae 40g, Poria 30g, Rhizoma Alismatis 30g
Technology: Radix Ophiopogonis powder is broken into 80 purpose fine powders, the Cortex Moutan pulverize at low temperature becomes 80 purpose fine powders; Fructus Corni, Fructus Schisandrae Chinensis, Rhizoma Alismatis are with 50% ethanol extraction 3 times; Add for the first time 10 times of amount 50% ethanol extractions 5 hours, added 8 times of amount 50% ethanol extractions for the second time 3 hours, added 5 times of amount 50% ethanol extractions for the third time 1 hour; Filter; Merge extractive liquid, reclaims ethanol, and being condensed into when relative density is 80 ℃ is 1.10~1.15 thick pastes; Radix Rehmanniae Preparata, adds 10 times of water gagings for the first time and extracted 3 hours again with Rhizoma Dioscoreae, Poria decocte with water 4 times earlier with boiling water lixiviate 3 hours; Adding for the second time 8 times of water gagings extracted 2 hours; Add 6 times of water gagings for the third time and extracted 1 hour, add 5 times of water gagings and extracted collecting decoction 0.5 hour for the 4th time; Filter, it is 1.10~1.15 thick pastes that filtrating is condensed into when relative density is 80 ℃; Above-mentioned fine powder and thick paste mixing are processed granule, and 60 ℃ of dryings add the magnesium stearate of dried grain amount 0.5% again, mixing, and tabletting, the bag film-coat promptly gets tablet.
Usage and consumption: oral, a 3-4 sheet, 3 times on the one.
Embodiment 4:
Prescription: Radix Ophiopogonis 120g, Fructus Schisandrae (processed) 20g, Radix Rehmanniae Preparata 80g, Fructus Corni (processed) 160g, Cortex Moutan 30g, Rhizoma Dioscoreae 40g, Poria 120g, Rhizoma Alismatis 120g
Technology: Radix Ophiopogonis powder is broken into 120 purpose fine powders, the Cortex Moutan pulverize at low temperature becomes 120 purpose fine powders; Fructus Corni, Fructus Schisandrae Chinensis, Rhizoma Alismatis added 10 times of amount 70% ethanol extractions for the first time 4 hours with 70% ethanol extraction 2 times, added 8 times of amount 70% ethanol extractions for the second time 2 hours; Filter; Merge extractive liquid, reclaims ethanol, and being condensed into when relative density is 80 ℃ is 1.10~1.15 thick pastes; Radix Rehmanniae Preparata is earlier with boiling water lixiviate 5 hours; With Rhizoma Dioscoreae, Poria decocte with water 3 times, add 10 times of water gagings for the first time and extracted 2 hours again, add 8 times of water gagings for the second time and extracted 2 hours; Adding 5 times of water gagings for the third time extracted 0.5 hour; Collecting decoction filters, and it is 1.10~1.15 thick pastes that filtrating is condensed into when relative density is 80 ℃; Above-mentioned fine powder and thick paste mixing are processed granule, and 60 ℃ of dryings add the magnesium stearate of dried grain amount 1% again, mixing, and tabletting, sugar coating promptly gets tablet.
Usage and consumption: oral, a 3-4 sheet, 3 times on the one.