CN101214325B - Method for preparing compound 'chenxiangwei'medicine and new use thereof - Google Patents
Method for preparing compound 'chenxiangwei'medicine and new use thereof Download PDFInfo
- Publication number
- CN101214325B CN101214325B CN2007103060644A CN200710306064A CN101214325B CN 101214325 B CN101214325 B CN 101214325B CN 2007103060644 A CN2007103060644 A CN 2007103060644A CN 200710306064 A CN200710306064 A CN 200710306064A CN 101214325 B CN101214325 B CN 101214325B
- Authority
- CN
- China
- Prior art keywords
- powder
- preparation
- radix
- weight portion
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Abstract
The present invention discloses a preparation method of compound sweet gastric medicine and the new purposes. The preparation method includes: 1. dried orange peel is extracted by 60 to 85 percent ethanol and ethanol is recovered and condensed into liquid extract; 2. costus root and grassleaf sweetflag rhizome steam is distilled and extracted to obtain volatile oil and the distillate is filtered and condensed into liquid extract; 3. rhubarb adopts superfine comminution and superfine powder is for standby; 4. sodium bicarbonate, heavy magnesium carbonate and aluminum hydroxide are respectivelysmashed into fine powder and evenly mixed; 5. the liquid extract of dried orange peel and the liquid extract of costus root and grassleaf sweetflag rhizome are mixed and added with the superfine powder of rhubarb and the fine powder of odium bicarbonate, heavy magnesium carbonate and aluminum hydroxide, which is granulated, dried and sprayed with the volatile of costus root and grassleaf sweetflag rhizome, evenly mixed and made into pills or capsules. The compound sweet gastric medicine provided by the present invention has pharmacological action on the Central Nervous System, especially calm, pain release, hypnogenesis and convulsion resistance.
Description
Technical field
The present invention relates to field of medicaments, refer more particularly to a kind of compound preparation of compositions method and new purposes thereof.
Background technology
The present invention is on the compound sheet basis of recording on " Ministry of Health of the People's Republic of China's ministry standard " the 18, through improving technology and a new technique of substantive innovation being arranged.The compound sheet is name side, the bonded Jiangxi of Chinese medicine and western medicine, records the local drug standard in Jiangxi Province the earliest.The inventor lists national standard in after by the standard that improves the quality, afterwards the inventor again to the preparation technology of this product, pharmacology pharmacodynamic, toxicology, clinically done systematic research work, make this product be listed in national Chinese medicine protection kind.
Along with medical technology significant progress, the preparation method of compound of the present invention also general no longer all is used as medicine with the crude drug powder of traditional common pulverizing.Make a general survey of the patent application official documents and correspondence of existing three compounds, they have the Chinese medicine and western medicine compound preparation of definite curative effect to do some improvement to this from different perspectives.Number of patent application is the preparation method of 03118496.0 compound dispersible tablet, and this method is Pericarpium Citri Reticulatae, the Radix Aucklandiae, Rhizoma Acori Gramineii extract volatile oil, and adopts the beta cyclodextrin inclusion technique to form clathrate, and medicinal residues are ground into fine powder, granulate, and make dispersible tablet.This invention seemingly has innovation, but still has bigger defective.As extract medicinal residues behind the volatile oil and still pulverize and be used as medicine, not only uneconomical but also science not can not reduce taking dose, does not overcome the defective that whole pulverizing are used as medicine, and has increased the operation of unnecessary extraction volatile oil on the contrary.
Another application for a patent for invention number is the patent of compound sheet of 03116870.1 and preparation method thereof, the technology of this patent is consistent with prescription, the process recipes of the compound sheet that 18 of Ministry of Public Health record, all medical material and medicinal chemicals are pulverized the back and are granulated tabletting.The present invention has adopted that water is carried, alcohol extraction and micronizing, with its this patent essential distinction is arranged.
The 3rd number of patent application is 03124507.2 the compound ball and the patent of preparation method, and this patented technology scheme and 03118496.0 patent scheme are similar.It is characterized in that Pericarpium Citri Reticulatae, the Radix Aucklandiae, Rhizoma Acori Gramineii extract volatile oil and make clathrate with cyclodextrin inclusion technique, medicinal residues are pulverized back and Radix Et Rhizoma Rhei powder and other chemical medicated powder mixing pills.This technology remains all medical materials at last and all is used as medicine with medicated powder, especially extracting medical material behind the volatile oil pulverizes to be used as medicine again and is used as medicine not as good as directly pulverizing, because the medicinal residues behind the extraction volatile oil are not easy drying and pulverizing, increased production process, be uneconomical, unscientific innovation equally.Though Pericarpium Citri Reticulatae is through water distillation and extraction volatile oil, its effective active composition Pericarpium Citri Reticulatae glycosides content is extremely low, can not bring into play therapeutical effect well, and this patent also only is confined to the protection of pill dosage form, and technical scheme and above-mentioned patent do not have substantive distinguishing features and progress.
Innovation part of the present invention is at medical material effective site different with the effective active composition and adopt different extraction processing methods.
Pericarpium Citri Reticulatae among the present invention adopts alcohol reflux, and the Radix Aucklandiae, Rhizoma Acori Graminei adopt water vapour distillation volatile oil, and Radix Et Rhizoma Rhei adopts superfine communication technique, and all the other chemical medicines all adopt common crushing technology to be ground into fine powder, handles being based on following reason like this:
Pericarpium Citri Reticulatae is the dry mature skin of rutaceae orange (citrus reticulate blanco) and variety thereof, mainly contain chemical constituents such as volatile oil, flavonoid, alkaloid, inositol, mainly contain limonene in the volatile oil, flavonoid is mainly Hesperidin.The traditional Chinese medical science thinks that Pericarpium Citri Reticulatae has the function of regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.Modern pharmacological research shows, Pericarpium Citri Reticulatae shows as two-ways regulation to gastrointestinal smooth muscle to the effect of digestive system, can suppress gastrointestinal motility, again can excited gastrointestinal motility, the activity of digestive enzyme there is obvious facilitation.Pericarpium Citri Reticulatae glycosides in the Pericarpium Citri Reticulatae is as main effectively one of active component, it in distillation and water in the preparation after carrying content very little, Pericarpium Citri Reticulatae glycosides content is higher in alcohol-extracted extract, pharmacological action is stronger (sees Pericarpium Citri Reticulatae volatile oil extraction process in the preferred lowering blood-fat and reducing weight capsule of orthogonal experiment " Chinese experimental pharmacology of Chinese medical formulae magazine ", the 13rd the 4th phase of volume, in April, 2007, Yao wind and cloud, the 31st the 6th phase of volume of Hesperidin extraction process experimental teaching research " Guiyang Medical College journal " in Xiao Hongbin fore-telling etc. and the Pericarpium Citri Reticulatae, in December, 2006).
The Radix Aucklandiae is the dry root of chrythanthemum Radix Aucklandiae Aucklandia lappa Qencne..The Radix Aucklandiae has the effect of promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion.Volatile oil is the main effectively medicinal part of the Radix Aucklandiae, contains multiple sesquiterpenoids, and is the highest with costunolide, Dehydrocostunolide lactone, ∝-costol, ∝-costic acid content especially, has antiinflammatory, antitumor, antiviral biological activity.The present invention adopts the way of distillation to extract volatile oil of Radix Aucklandiae, and distillate is condensed into fluid extract, can fully improve Radix Aucklandiae yield of effective components, strengthens clinical efficacy.
Rhizoma Acori Graminei is the dry tuber of Araeceae Rhizoma Acori Graminei Acorus tatarinowii Sch ott.The pharmacopeia record, Rhizoma Acori Graminei has the function of removing dampness appetizing, the eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae.Modern study shows that Rhizoma Acori Graminei contains 34 kinds of volatile oil, comprises beta-Asarone, ∝-asaricin, caryophyllene, and sesquiterpenoids, phenylpropyl alcohol chlorins compound are main component of essential oil.Also have compositions such as saccharide, organic acid, aminoacid in addition.By distillating extracting oil, water-soluble active ingredient is condensed into fluid extract after separating is kept, and will produce positive effect to reducing taking dose, reduce untoward reaction and improving clinical efficacy.
The compound sheet that " ministry standard " 18 recorded is a relieving QI stagnancy in the stomach, relieving gastric hyperacidity to alleviate stomachache.Be used for diseases such as qi stagnation type pain of gastral cavity, gastral cavity abdomen feeling of fullness, belch acid regurgitation, gastric and duodenal ulcers, chronic gastritis are seen the above-mentioned symptom person that belongs to the syndrome of stagnation of QI.
The inventor is through discovering, the compound preparation of the present invention's preparation has pharmacological action to the central nervous system, refers in particular to it and can be used for calmness, analgesia, hypnosis, the new purposes of anticonvulsant.
Summary of the invention
The object of the present invention is to provide a kind of preparation method and new purposes thereof of compound.
The present invention is implemented by following scheme
The present invention realizes by following steps: with Pericarpium Citri Reticulatae, the Radix Aucklandiae, Rhizoma Acori Graminei, Radix Et Rhizoma Rhei, sodium bicarbonate, aluminium hydroxide, Heavy Magnesium Carbonate is that raw material is made.
1, Pericarpium Citri Reticulatae ethanol extraction reclaims ethanol, gets Pericarpium Citri Reticulatae fluidextract;
2, the Radix Aucklandiae, Rhizoma Acori Graminei water vapour distillation volatile oil, distillate is condensed into fluid extract, and device is preserved in addition, and is standby;
3, with Radix Et Rhizoma Rhei, be ground into 80 middle fine powder earlier, again superfine powder be broken into 0.1 μ m-10 μ m micropowder, less than the mixed powder of the fine powder of the nano powder of 0.1 μ m and 10 μ m-150 μ m, and feed intake by the recovery rate that is no less than 95%;
4, sodium bicarbonate, aluminium hydroxide, Heavy Magnesium Carbonate pulverize separately are become fine powder, cross 120 mesh sieves, mixing, standby;
5, the Radix Aucklandiae, Rhizoma Acori Graminei fluid extract are mixed with Pericarpium Citri Reticulatae fluidextract,, join in the mixed flow extractum the fine powder of step 4 and the Radix Et Rhizoma Rhei mixed powder mixing of step 3, add adjuvant, granulate drying, spray into the Radix Aucklandiae, Rhizoma Acori Graminei volatile oil, sieve, make capsule/tablet.
The weight portion of above-mentioned raw materials medicine is: Pericarpium Citri Reticulatae 75-100 Radix Aucklandiae 12-30 Rhizoma Acori Graminei 8-20 Radix Et Rhizoma Rhei 12-30 sodium bicarbonate 12-25 aluminium hydroxide 75-100 Heavy Magnesium Carbonate 12-25
Step 1 Pericarpium Citri Reticulatae of the present invention adds 8-12 and doubly measures ethanol with the ethanol extraction of 60%-85%, reflux, extract, 2-3 time, and each 1-2.5 hour, merge backflow, filter, reclaim ethanol, be condensed into fluid extract; Also available percolation extracts, usefulness 60%-85% alcohol dipping percolation after 12-48 hour, and the liquid of just filtering device is in addition preserved, percolation speed can every kilogram of speed of medical material 3-5ml/ minute, merge with the liquid of just filtering behind the continuous diacolation liquid recycling ethanol, reclaim ethanol, continue to be condensed into fluid extract.
The Radix Aucklandiae of step 2 of the present invention, Rhizoma Acori Graminei add water distillation 2-3 time that 8-14 doubly measures, and each 1-2.5 hour, collect volatile oil, the water distillate merges, filters to be condensed into fluid extract, device preservation in addition, standby.
Above-mentioned distillate filters available specialized material ceramic membrane microfiltration, also can behind high speed centrifugation, divide and get supernatant, or with adsorption clarifications such as flocculating agent such as flocculate with chitosan clarifier, 101 fruit juice clarifiers, Ovum Gallus domesticus album flocculating agent and remove particle bigger in the medicinal liquid, also available alcohol deposition method is removed most of impurity, both can singly use above-mentioned defecation method, but also use in conjunction, as coarse filtration-adsorption clarification, adsorption clarification-high speed centrifugation, coarse filtration-microfiltration, coarse filtration-precipitate with ethanol.
Step 3 Radix Et Rhizoma Rhei of the present invention, be ground into 80 middle fine powder earlier, micronizing again, the particle diameter of powder is that 0.1 μ m is following, the mixed powder of 0.1 μ m-10 μ m and 10 μ m-150 μ m, wherein 0.1 μ m mixed powder following and 0.1 μ m-10 μ m is main, and feeds intake by the powder rate that gets that is no less than 95%.
The present invention 4 sodium bicarbonate, aluminium hydroxide, Heavy Magnesium Carbonate medicinal chemicals pulverize separately become fine powder, cross 120 mesh sieves, mixing.
Beneficial effect of the present invention:
1, the present invention adopts superfine powder to be broken into the mixed powder plastochondria of micropowder, nano powder and fine powder the Radix Et Rhizoma Rhei Chinese crude drug, makes plant cell wall breaking, helps the stripping of medical material effective ingredient, improves dissolution, and dissolve scattered time limit is short, and good absorbing is rapid-action, the bioavailability height; In the industrialization field, because of micronizing is to carry out, do not produce dust pollution in closed system, can reach the environmental protection production requirement, also can improve simultaneously the powder rate.
2, the present invention adopts water vapour distillation volatile oil with Rhizoma Acori Graminei, the Radix Aucklandiae, and Pericarpium Citri Reticulatae adopts the technology of alcohol extraction effective ingredient to be used as medicine with the alternative full powder of extract, can reduce untoward reaction on the one hand, improves curative effect; On the other hand, owing to substitute the crude drug powder preparation, can reduce taking dose with fluid extract; The 3rd, to control easily with fluid extract its biological indicator of being used as medicine, bacterial population is limited the quantity of and is had only 1/10th of crude drug powder preparation, and mycete, yeast also are lower than the preparation that is used as medicine with the crude drug powder.
3, the present invention especially has calmness, analgesia, hypnosis, anticonvulsant effect except the 18 record of ministry standard can be used for also the central nervous system being had effect gastric and duodenal ulcers, the chronic gastritis.
The specific embodiment
Further specify the present invention below by embodiment.It should be understood that the embodiment of the invention only is used to illustrate the present invention, rather than limitation of the present invention, under design prerequisite of the present invention, its modification and/or variant all belong to the scope of protection of present invention.Except as otherwise noted, the percent among the present invention is percetage by weight, and in addition, (W/W) in the description of the present invention is meant weight ratio or weight ratio concentration, (V/V) is meant volume ratio or volume by volume concentration, and W/V is meant the ratio of weight and volume.
Embodiment 1
Pericarpium Citri Reticulatae 80g Radix Aucklandiae 20g Rhizoma Acori Graminei 11g Radix Et Rhizoma Rhei 20g sodium bicarbonate 20g aluminium hydroxide 80g Heavy Magnesium Carbonate 20g
Get Pericarpium Citri Reticulatae, the alcohol reflux secondary with 75%, each 2 hours, merge extractive liquid, reclaims ethanol, gets fluid extract, and was standby; The Radix Aucklandiae, Rhizoma Acori Graminei steam distillation secondary, each 2 hours, volatile oil in addition device was preserved, and distillate filters, and it is standby to be condensed into fluid extract; Get Radix Et Rhizoma Rhei, be ground into 80 middle fine powder earlier, superfine powder is broken into the micropowder of 0.1 μ m-10 μ m and less than the nano powder of 0.1 μ m, the mixed powder of 10 μ m-150 μ m again, and by be no less than 95% the powder rate be left and taken standby; Sodium bicarbonate, Heavy Magnesium Carbonate, aluminium hydroxide pulverize separately become fine powder, and it is standby to cross 120 mesh sieves; Pericarpium Citri Reticulatae fluidextract and the Radix Aucklandiae, Rhizoma Acori Graminei fluid extract are merged, add Radix Et Rhizoma Rhei powder and sodium bicarbonate, Heavy Magnesium Carbonate, aluminium hydroxide fine powder and dextrin, granulate, drying sprays into the Radix Aucklandiae, Rhizoma Acori Graminei volatile oil, and mixing is made tablet.
Experimental example 1 analgesic test (writhing method)
Get 30 mices, male and female half and half, weigh, be divided into 3 groups at random, gavage corresponding medicine by clinical dosage respectively, matched group gavages isopyknic normal saline, irritate 30min behind the stomach, the glacial acetic acid solution of every group of lumbar injection 0.6% (0.2ml/ is only), the body number of times is turned round by observation group in 30min, calculate the analgesia rate, the results are shown in Table 1.
Table 1 compound to the mice chemistry cause the pain influence (
N=10)
| Group | Dosage/g.kg | Turn round the body number of times | Analgesia rate (%) |
| Normal saline group compound Xianglian Wan group | 0.2ml/ only 97.40 17.55 | 18.5±2.0 5.0±1.4 ** 13.2±5.8 * | 72.43 28.65 |
Compare with the normal saline group,
*P＜0.05
*P＜0.01
The result shows that under the clinical dosage of medicament, analgesia rate of the present invention is 72.43%, and has compared significant difference with matched group, illustrates that the present invention has analgesic activity.
Test 2 preparations of the present invention to the influence of the length of one's sleep of mice sub-threshold dose pentobarbital sodium
Get 60 of male mices, be divided into 4 groups at random, be high, medium and low dosage group of compound sheet and negative control group, observation group respectively by 95,75, the 55g/kg dosage, each organized the mouse stomach administration 7 days, 1 time/day, negative control group gives normal saline, after the last administration 30 minutes, lumbar injection pentobarbital sodium (55mg/kg body weight), the time of record sleep appearing and subsiding respectively.Because of pentobarbital sodium itself is similar to positive controls, compound of the present invention is that the antagonism pentobarbital sodium is slept, and does not therefore need to carry out positive control at this.
Table 2 compound sheet to the influence of the length of one's sleep of mice sub-threshold dose pentobarbital sodium (
N=15)
| Group | Time for falling asleep (min) | Sleep time (min) | The hypoxia death time (min) |
| Dosage group low dose group of the present invention among negative control group high dose group the present invention of the present invention | 5.09±0.78 5.36±1.07 5.77±2.02 5.58±1.50 | 36.33±14.32 17.57±6.92 ** 30.75±12.31 18.22±6.86 ** | 36.21±5.0 46.96±8.2 * 47.15±4.77 ** 44.60±8.20 * |
Compare with negative control group
*P＜0.01
*P＜0.001
The result shows, compound sheet high and low dose group of the present invention all can significantly shorten the mice sleep persistent period, compare with negative control group, has utmost point significant difference (P＜0.001), middle dosage group has the trend that shortens the mice sleep persistent period, but compares there was no significant difference with negative control group.
Embodiment 2
Pericarpium Citri Reticulatae 75g Radix Aucklandiae 25g Rhizoma Acori Graminei 15g Radix Et Rhizoma Rhei 25g sodium bicarbonate 20g aluminium hydroxide 75g Heavy Magnesium Carbonate 20g
Get Pericarpium Citri Reticulatae, add the alcohol reflux secondary of 10 times of weight portions 80%, each 2 hours, reclaim ethanol, get fluid extract, standby; The Radix Aucklandiae, Rhizoma Acori Graminei add the water distillation secondary of 8 times of weight portions respectively, and 2 hours for the first time, 1.5 hours for the second time, volatile oil device was in addition preserved, and distillate filters, and it is standby to be condensed into fluid extract; Get Radix Et Rhizoma Rhei, superfine powder is broken into the micropowder of 0.1 μ m-10 μ m and less than the nano powder mixed powder of 0.1 μ m, and by be no less than 95% the powder rate be left and taken standby; Sodium bicarbonate, Heavy Magnesium Carbonate, aluminium hydroxide pulverize separately become fine powder, and it is standby to cross 120 mesh sieves; Pericarpium Citri Reticulatae fluidextract and the Radix Aucklandiae, Rhizoma Acori Graminei fluid extract are merged, add Radix Et Rhizoma Rhei powder and sodium bicarbonate, Heavy Magnesium Carbonate, aluminium hydroxide fine powder, granulate, drying sprays into the Radix Aucklandiae, Rhizoma Acori Graminei volatile oil, and mixing is made capsule.
Test 3 mice hot-plate analgesic test
Screen qualified female mice, be divided into model group, indometacin matched group and compound capsule of the present invention observation group, mice is placed on the hot plate to the sick threshold value of sufficient required time (s) as Mus occurring licking, allly licks the used time of foot less than the 5s or the difference of abandoning greater than 30s or leaper.Qualified mice is divided into 5 groups at random, survey its pain threshold again, as the pain threshold before this Mus administration, observe the effect that is subjected to reagent, mice fasting 12h before the test, each organizes equal gastric infusion, after administration 30,60,90,120min surveys the sick threshold value of mice respectively, and is still reactionless as 60s, mice is taken out, in order to avoid scald, calculate with 60s its threshold of pain.The results are shown in Table 3.
The influence of table 3 hot plate method induced mice pain threshold
| Group | Dosage (g/kg) | Number of animals | Incubation period before the administration | Incubation period after the administration (s) | |||
| 30min | 60min | 90min | 120min | ||||
| Model group indometacin group Co CHENXIANG capsule for treating gastropathy Co CHENXIANG capsule for treating gastropathy Co CHENXIANG capsule for treating gastropathy | 0.01625?21.06?7.02?2.34 | ?12?12?11?11?11 | ?15.98±5.34?15.33±6.31?15.63±3.55?15.77±5.87?15.36±4.7 | ?16.83±4.26?19.76±6.46?22.26±6.09 *?17.91±5.27?17.29±6.93 | 15.24±3.71 28.58±10.54 19.92±6.77 ** 21.40±4.27 * 22.12±4.43 * | 16.26±4.21 25.12±8.61 ** 19.15±4.32 18.75±2.83 17.10±3.46 | 13.72±2.96 22.43±5.98 * 20.10±9.35 * 18.52±4.46 19.57±4.97 * |
Compare with model group
*P＜0.05,
*P＜0.01
The result shows, compound capsule of the present invention after administration 30,60,90,120min can improve the pain threshold of mice, in, low dose group all can be after administration 60,120min improves the pain threshold of mice, with model control group significant difference is arranged relatively.
Claims (5)
1. the preparation method of a compound is characterized in that it may further comprise the steps: get Pericarpium Citri Reticulatae 75-100 weight portion,, reclaim ethanol with the ethanol extraction of 60%-85%, fluid extract, standby; Radix Aucklandiae 12-30 weight portion, Rhizoma Acori Graminei 8-20 weight parts water distillating extracting oil, distillate filter, and it is standby to be condensed into fluid extract; Get Radix Et Rhizoma Rhei 12-30 weight portion, be ground into the middle fine powder of 80 mesh sieves earlier, micronizing again, and get the powder rate by the superfine powder that is no less than 95% and leave and take standby; Sodium bicarbonate 12-25 weight portion, Heavy Magnesium Carbonate 12-25 weight portion, aluminium hydroxide 75-100 weight portion pulverize separately become fine powder, and it is standby to cross 120 mesh sieves; Pericarpium Citri Reticulatae fluidextract and the Radix Aucklandiae, Rhizoma Acori Graminei fluid extract are merged, add Radix Et Rhizoma Rhei powder and sodium bicarbonate, Heavy Magnesium Carbonate, aluminium hydroxide fine powder, granulate, drying sprays into the Radix Aucklandiae, Rhizoma Acori Graminei volatile oil, and mixing is made the tablets/capsules agent.
2. the preparation method of compound as claimed in claim 1 is characterized in that the ethanol extraction Pericarpium Citri Reticulatae can be with percolation or circumfluence method.
3. the preparation method of compound as claimed in claim 1 is characterized in that it is made by following weight portion composition: Pericarpium Citri Reticulatae 75-100 Radix Aucklandiae 12-30 Rhizoma Acori Graminei 8-20 Radix Et Rhizoma Rhei 12-30 sodium bicarbonate 12-25 Heavy Magnesium Carbonate 12-25 aluminium hydroxide 75-100.
4. the compound for preparing as each described method of claim 1-3.
5. as the purposes of each described method of claim 1-3 in the preparation medicine, described medicine has effect to the central nervous system, and this act as calmness, analgesia, hypnosis, anticonvulsant effect.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007103060644A CN101214325B (en) | 2007-12-29 | 2007-12-29 | Method for preparing compound 'chenxiangwei'medicine and new use thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007103060644A CN101214325B (en) | 2007-12-29 | 2007-12-29 | Method for preparing compound 'chenxiangwei'medicine and new use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101214325A CN101214325A (en) | 2008-07-09 |
| CN101214325B true CN101214325B (en) | 2010-12-08 |
Family
ID=39620873
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2007103060644A Active CN101214325B (en) | 2007-12-29 | 2007-12-29 | Method for preparing compound 'chenxiangwei'medicine and new use thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101214325B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111304046A (en) * | 2020-04-24 | 2020-06-19 | 南国百乐(福安)食品科技有限公司 | Grape fruit vinegar brewing method |
| CN116350699B (en) * | 2023-06-01 | 2023-08-15 | 弘美制药（中国）有限公司 | Preparation method of rhizoma acori graminei volatile oil and stomach bismuth magnesium granule compound preparation |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1449797A (en) * | 2003-05-09 | 2003-10-22 | 江西诚志信丰药业有限责任公司 | Compound chenxiang gastric tablet and preparation process thereof |
| CN1456216A (en) * | 2003-01-16 | 2003-11-19 | 毛友昌 | Preparing method for composite chenxiang stomach dispersed pills |
-
2007
- 2007-12-29 CN CN2007103060644A patent/CN101214325B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1456216A (en) * | 2003-01-16 | 2003-11-19 | 毛友昌 | Preparing method for composite chenxiang stomach dispersed pills |
| CN1449797A (en) * | 2003-05-09 | 2003-10-22 | 江西诚志信丰药业有限责任公司 | Compound chenxiang gastric tablet and preparation process thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101214325A (en) | 2008-07-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102225152B (en) | Preparation method of Maiwei rehmannia oral preparation | |
| CN101181351B (en) | Chinese medicine composition for resisting tiredness and reinforcing immune as well as method of making the same | |
| CN1840166A (en) | Modern Chinese medicinal oral liquid of 'Wen Dan Tang' and preparation method thereof | |
| CN1723981A (en) | Novel use of extractive of Momordica grosvenori as adjuvant drug for preparing medicine | |
| CN1985922A (en) | Medicine composition for treating common cold and its preparing method | |
| CN101366858B (en) | Preparation method of medicament for clearing heat, discharging fire, dispelling wind and relieving pain | |
| CN101085039B (en) | Composition for preventing and treating diabetes (hyperglycaemia) and its preparation method | |
| CN101933973B (en) | Medicament composition for preventing and treating liver damage | |
| CN1471845A (en) | Healthy food with glossy and rhizoma as main material and preparing method thereof | |
| CN101214325B (en) | Method for preparing compound 'chenxiangwei'medicine and new use thereof | |
| CN102247479A (en) | Antitumor strong medicine and preparation method thereof | |
| CN102228547B (en) | Application of traditional Chinese medicine composition in preparing medicaments treating pancreatitis and/or cholecystitis | |
| CN101926869B (en) | Medicament for treating dizziness and headache and preparation method thereof | |
| CN104971088A (en) | Tibetan artemisia capillaris extract and preparation method, drug composition and application thereof | |
| CN106109521A (en) | A kind of Radix Notoginseng oral liquid | |
| CN1985917B (en) | Medicine composition for reducing blood sugar, reducing blood fat and controlling diabetes complication | |
| CN109674848A (en) | A kind of preparation method and purposes of licorice | |
| CN106309736B (en) | Anti-fatigue Chinese medicinal composition and its preparation method and application | |
| CN100998787B (en) | Traditional Chinese medicine effervescent tablets for treating gastrointestinal disease and its preparing method | |
| CN102416138A (en) | Composition with effects of dispelling effects of alcohol, reducing blood fat and nourishing stomach, and preparation method thereof | |
| CN100479837C (en) | Weinakang for treating ischemic cerebrovascular disease and senile dementia and preparation method thereof | |
| CN102631482A (en) | Chinese medicinal composition for preventing and treating diabetes and complications | |
| CN102397416A (en) | Medicinal composition for treating erectile dysfunction (ED), its preparation method and preparations | |
| CN1302792C (en) | Medicine composition with the action of relieving alcoholism and protecting liver and its application | |
| CN101269100A (en) | Application of goldenrod in preparing medicament for treating and preventing cancer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CP03 | Change of name, title or address |
Address after: 335200 north of national highway 320, Jiaotong North Road, Yujiang District, Yingtan City, Jiangxi Province Patentee after: Jiangxi Kangenbei tianshikang Pharmaceutical Co.,Ltd. Address before: 21 Jianshe Road, Yingtan City, Jiangxi Province Patentee before: Jiangxi Herbi-Sky Co.,Ltd. |
|
| CP03 | Change of name, title or address |