CN106309736B - Anti-fatigue Chinese medicinal composition and its preparation method and application - Google Patents
Anti-fatigue Chinese medicinal composition and its preparation method and application Download PDFInfo
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- CN106309736B CN106309736B CN201610975325.0A CN201610975325A CN106309736B CN 106309736 B CN106309736 B CN 106309736B CN 201610975325 A CN201610975325 A CN 201610975325A CN 106309736 B CN106309736 B CN 106309736B
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- radix astragali
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of anti-fatigue Chinese medicinal compositions and its preparation method and application.Chinese medicine composition of the invention is by including that the component of the following raw material medicine is made: 20~50 parts by weight of emblic, 20~50 parts by weight of Radix Astragali, 10~30 parts by weight of fructus lycii.Anti-fatigue Chinese medicinal composition of the invention can significantly relieve fatigue the fatigue state of the body under state, especially hypobaric.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, especially a kind of antifatigue Chinese medicine composition further relates to the Chinese medicine group
Close the preparation method and purposes of object.
Background technique
Fatigue is a kind of physiological phenomenon of complexity, body under certain condition, due to for a long time or overwrought physical strength
Or labor efficiency caused by mental activity tends to decline, can lead to working efficiency reduction, mistake and accident increases.After fatigue occurs
If cannot restore in time, gradually accumulate, also result in overwork, makes body that endocrine disturbance, immunity degradation occur, even
There is organic disease, becomes an important factor for threatening human health.
In addition to the fatigue on ordinary meaning, plateau low pressure also causes body fatigue symptom occur, and labour capacity obviously drops
It is low.Plateau elevation generally in 3000m or more, most of humans and animals without altitutde training reach 3000m this highly with
Afterwards, due to decrease in oxygen partial pressure in atmospheric pressure, body reduces low-oxygen environment tolerance, it is difficult to adapt to and cause anoxic, can all go out
Now apparent fatigue symptom and sign；More than this height, the adaptive change of physiology, biochemistry and form etc. will become
More come obviously, and there is apparent biological property.Under hypobaric, the labour capacity of body can be generally reduced, seriously
Person can hardly do high-intensitive operation.
There are many drugs and health food with the effect that relieves fatigue currently on the market, and mostly expensive.Text
Research is offered to report plurality of Chinese compound and all have certain antifatigue effect.Application No. is 201110007916.6 China specially
Benefit application discloses a kind of pharmaceutical composition with antifatigue effect, by Radix Astragali, ginseng, Radix Angelicae Sinensis, dried orange peel, rhizoma cyperi and fructus lycii
Etc. Chinese medicinal compositions.Application No. is 200810033746.7 Chinese patent applications to disclose a kind of anti-fatigue Chinese medicinal composition, contains
There are pharmaceutically acceptable carrier and a effective amount of raw medicinal material or its water extract or aqueous organic solvent extract, it is described
Raw medicinal material contains selected from Herba Epimedii, cordyceps sinensis, pilose antler, Cortex Eucommiae, Fructus Corni, fructus lycii, teasel root, rhizoma cibotii, ginseng, the West
Ginseng, Radix Astragali, donkey-hide gelatin, Rehmannia glutinosa, mulberry fruit, folium isatidis, Fructus Forsythiae, Radix Glycyrrhizae, wild chrysanthemum, cortex moutan, ginkgo leaf or west safflower it is a variety of
The extract of medicinal material or their water extract or aqueous organic solvent.Above-mentioned pharmaceutical composition all has certain antifatigue
Effect, but not for the fatigue symptom under hypobaric.
There is definite resist with definite reliable antifatigue effect, particularly under hypobaric therefore, it is necessary to a kind of
The Chinese medicine composition of tired effect.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine composition, which has significant antifatigue effect, special
It is not that there is significant antifatigue effect in hypobaric.
It is a further object of the present invention to provide the preparation methods of the Chinese medicine composition.
Another object of the present invention is to provide the Chinese materia medica preparation containing the Chinese medicine composition.
It is yet another object of the invention to provide the purposes of the Chinese medicine composition.
The purpose of the present invention is what is be achieved through the following technical solutions.
The present invention provides a kind of for antifatigue Chinese medicine composition, and the composition is by the component including the following raw material medicine
It is made:
20~50 parts by weight of emblic, 10~30 parts by weight of 20~50 parts by weight of Radix Astragali and fructus lycii.
Chinese medicine composition of the invention, it is preferable that the composition is by including that the component of the following raw material medicine is made:
25~45 parts by weight of emblic, 15~30 parts by weight of 30~45 parts by weight of Radix Astragali and fructus lycii.
Chinese medicine composition of the invention, it is preferable that the composition is by including that the component of the following raw material medicine is made:
30 parts by weight of emblic, 25 parts by weight of 35 parts by weight of Radix Astragali and fructus lycii；Or
32.5 parts by weight of emblic, 20 parts by weight of 37.5 parts by weight of Radix Astragali and fructus lycii；Or
37.5 parts by weight of emblic, 25 parts by weight of 37.5 parts by weight of Radix Astragali and fructus lycii.
Chinese medicine composition of the invention, it is preferable that the component only includes the bulk pharmaceutical chemicals.
The present invention also provides the preparation methods of the Chinese medicine composition.Preferably, the preparation method is selected from and is pulverized and mixed
Method, water extraction method or ethanol water extraction method.
According to embodiment of the present invention, the preparation method includes: to crush emblic, Radix Astragali and fructus lycii,
It is uniformly mixed, obtains the Chinese medicine composition.
According to another implementation of the invention, the preparation method includes the following steps:
(1) it by emblic, Radix Astragali and fructus lycii water heating and refluxing extraction or ultrasonic extraction 1~5 time, is added is based on every time
The water of 1~20 times of amount of emblic, Radix Astragali and fructus lycii total weight, is extracted 0.5~5 hour every time, and filtering, filtrate merges；
(2) filtrate is concentrated.
Yet another embodiment according to the present invention, the preparation method include the following steps:
(1) emblic, Radix Astragali and fructus lycii are heated to reflux or ultrasonic extraction 1~5 time, be added every time based on emblic,
The concentration of 1~20 times of amount of Radix Astragali and fructus lycii total weight is the ethanol water of 20~100vol%, extracts 0.5~5 every time
Hour, filtering, filtrate merges；
(2) filtrate is concentrated.
The present invention also provides a kind of antifatigue Chinese materia medica preparations, and the Chinese materia medica preparation includes above-mentioned Chinese medicine composition, and is wrapped
Containing pharmaceutically acceptable auxiliary material.
The present invention also provides the use that the Chinese medicine composition is used to prepare prevention or the drug or health food that relieve fatigue
On the way.
Effect experiment confirms, using this three tastes bulk pharmaceutical chemicals of emblic, Radix Astragali and fructus lycii, and with special ratios of the invention
After compatibility, Chinese medicine composition obtained can prevent fatigue, and can rapidly, effectively relieve fatigue state, especially prevent
With the fatigue state for alleviating the body under plateau low pressure environment.
Specific embodiment
The present invention is described in more detail below with reference to specific real-time mode, but protection scope of the present invention and unlimited
In this.
In the present invention, the concentration of ethanol water refers to the concentration expressed in percentage by volume of wherein ethyl alcohol, i.e. vol%.In the present invention,
When the concentration of the ethanol water is 100vol%, refer to dehydrated alcohol.
" pharmaceutically acceptable " of the invention means that it can be used for preparing drug or preparation, usually safe and nontoxic
And neither biologically nor undesirable in other aspects, and including it animal doctor is used and mankind's medicine
Object use is acceptable.
In the present invention, the emblic is that Euphorbiaceae (Euphorbiaceae) Leafflower (Phyllanthus) fallen leaves fill
The dry mature fruit of wood or dungarunga emblic Phyllanthus emblica L..The Radix Astragali is that leguminous plant Mongolia is yellow
Stilbene Astragalus membranaceus (Fisch.) Bge.var.Mongholicus (Bge.) Hsiao or Astragalus membranacus
The dry root of Astragalus membranaceus (Fisch.) Bge..The fructus lycii is also known as fructus lycii, is plant of Solanaceae Ningxia
The dry mature fruit of fructus lycii Lycium barbarum L..
<Chinese medicine composition>
Chinese medicine composition of the invention is made, three of the component including the bulk pharmaceutical chemicals of emblic, Radix Astragali and fructus lycii
The weight proportion of person is 20~50 parts by weight of emblic, 10~30 parts by weight of 20~50 parts by weight of Radix Astragali and fructus lycii.This three kinds
Bulk pharmaceutical chemicals have significant antifatigue effect with Chinese medicine composition made of the proportion, especially have under hypobaric
Significant antifatigue effect.A preferred embodiment according to the present invention, Chinese medicine composition of the invention is by including as follows
The component of the bulk pharmaceutical chemicals of weight proportion is made: 25~45 parts by weight of emblic, 30~45 parts by weight of Radix Astragali and fructus lycii 15~30
Parts by weight.A preferred embodiment according to the present invention, Chinese medicine composition of the invention is by including following weight proportion
The components of bulk pharmaceutical chemicals be made: 30~40 parts by weight of emblic, 18~28 parts by weight of 35~40 parts by weight of Radix Astragali and fructus lycii.
According to embodiment of the present invention, Chinese medicine composition of the invention is by the bulk pharmaceutical chemicals including following weight proportion
Component be made: 30 parts by weight of emblic, 25 parts by weight of 35 parts by weight of Radix Astragali and fructus lycii.
Another embodiment according to the present invention, Chinese medicine composition of the invention is by the bulk pharmaceutical chemicals including following weight proportion
Component be made: 32.5 parts by weight of emblic, 20 parts by weight of 37.5 parts by weight of Radix Astragali and fructus lycii.
Yet another embodiment according to the present invention, Chinese medicine composition of the invention is by the bulk pharmaceutical chemicals including following weight proportion
Component be made: 37.5 parts by weight of emblic, 25 parts by weight of 37.5 parts by weight of Radix Astragali and fructus lycii.
Other than emblic, Radix Astragali and fructus lycii, Chinese medicine composition of the invention prepares raw material and can contain or not
Contain other Pharmaceutical ingredients.According to embodiment of the present invention, Chinese medicine composition of the invention, Pharmaceutical ingredients are only by upper
Emblic, Radix Astragali and the fructus lycii composition of weight proportion are stated, and does not include other Pharmaceutical ingredients.
In the present invention, the emblic, Radix Astragali and fructus lycii can use health product or processed product.One according to the present invention
Embodiment, the Radix Astragali are made a living Radix Astragali or astragalus root, preferably astragalus root.
<preparation method>
Chinese medicine composition of the invention can be used the method for being pulverized and mixed, water extraction method or ethanol water extraction method and be prepared into
It arrives.
Described is pulverized and mixed method, is to crush emblic, Radix Astragali, fructus lycii, is uniformly mixed, obtains the Chinese traditional medicine composition
Object.Specifically, it is uniformly mixed after emblic, Radix Astragali and fructus lycii can individually being crushed, or by emblic, Radix Astragali and fructus lycii
Son crushes again after mixing, obtains Chinese medicine composition of the invention.The partial size of the crushing, which is subject to, is suitble to preparation.
The water extraction method can be selected from infusion method, decocting method, heating and refluxing extraction method or ultrasonic extraction.According to
An embodiment of the invention, the water extraction method are to extract emblic, Radix Astragali, fructus lycii respectively, filtering, by filtrate
Merge, concentration is optionally dried, obtains Chinese medicine composition of the invention.According to another implementation of the invention, institute
Stating water extraction method is extracted with water after mixing emblic, Radix Astragali, fructus lycii, filters, filtrate is concentrated, is optionally done
It is dry, obtain Chinese medicine composition of the invention.
According to embodiment of the present invention, the preparation method includes the following steps:
(1) it by emblic, Radix Astragali and fructus lycii water heating and refluxing extraction or ultrasonic extraction 1~5 time, is added is based on every time
The water of 1~20 times of amount of emblic, Radix Astragali and fructus lycii total weight, is extracted 0.5~5 hour every time, and filtering merges filtrate；
(2) filtrate is concentrated, obtains the Chinese medicine composition.
In step (1), it is preferable that extraction time is 1~3 time, more preferably 2~3 times；It is remaining that the weight of water is added every time
5~12 times, more preferably 6~10 times of Gan Zi, Radix Astragali and fructus lycii total weight；Each extraction time is 0.5~3 hour, more
Preferably 1~2 hour.
According to embodiment of the present invention, in step (1), by emblic, Radix Astragali and fructus lycii heating and refluxing extraction 1
~3 times, the water of 5~12 times of amounts based on emblic, Radix Astragali and fructus lycii total weight is added every time, it is small to extract 0.5~3 every time
When.
In the present invention, it is preferable that in step (1), extracted after emblic, Radix Astragali and fructus lycii are soaked in water, when immersion
Between be 0.2~2 hour, more preferably 0.5~1 hour.
In the present invention, the ethanol water extraction method can be selected from infusion process, heating and refluxing extraction method, ultrasonic extraction
Method or percolation.The concentration of the ethanol water is 20~100vol%, preferably 30~95vol%, more preferably 40
~75vol% is further preferably 50~75vol%.According to embodiment of the present invention, the ethanol water extraction method
It is to extract emblic, Radix Astragali, fructus lycii respectively, filtering merges filtrate, is concentrated, is optionally dried, obtains the present invention
Chinese medicine composition.According to another implementation of the invention, the ethanol water extraction method be by emblic, Radix Astragali,
It is extracted after fructus lycii mixing with ethanol water, filters, filtrate is concentrated, is optionally dried, Chinese medicine of the invention is obtained
Composition.
According to one embodiment of the present invention, the extracting method includes the following steps:
(1) emblic, Radix Astragali and fructus lycii are heated to reflux or ultrasonic extraction 1~5 time, be added every time based on emblic,
The ethanol water that the concentration of 1~20 times of amount of Radix Astragali and fructus lycii total weight is 20~100%, it is small to extract 0.5~5 every time
When, filtering merges filtrate；
(2) filtrate is concentrated, obtains the Chinese medicine composition.
In step (1), it is preferable that extraction time is preferably 1~4 time, and more preferably 2~3 times；The ethanol water being added every time
The concentration of solution is 40~75vol%, more preferably 50~75vol%；The weight for the ethanol water being added every time is emblic
2~15 times, more preferably 5~15 times of sub, Radix Astragali and fructus lycii total weight；Each extraction time is 1~3 hour, more preferably
It is 1~2 hour.
According to embodiment of the present invention, in step (1), emblic, Radix Astragali and fructus lycii are heated to reflux or are surpassed
Sound extracts 1~4 time, and the concentration that 2~15 times based on emblic, Radix Astragali and fructus lycii total weight amounts are added every time are 40~
The ethanol water of 75vol% extracts 1~3 hour every time.
In the present invention, in step (1), it is preferable that emblic, Radix Astragali and fructus lycii are added after ethanol water impregnates and mention
It takes, soaking time is 0.2~2 hour, more preferably 0.5~1 hour.
In above-mentioned water extraction method and ethanol water extraction method, the emblic, Radix Astragali and fructus lycii can directly with
Medicine materical crude slice feeds intake, and feeds intake again after may also pass through appropriate crush.
It should be appreciated that above-mentioned embodiment is only currently preferred preparation method, and preparation method of the invention is simultaneously
It is not limited to the embodiment as above provided.All Chinese medicine compositions using bulk pharmaceutical chemicals composition preparation of the invention, due to its raw material
The pharmacological property of medicine, compatibility relationship are constant, the effect for all having prevention and relieving fatigue.
<Chinese materia medica preparation>
Chinese materia medica preparation of the invention is using above-mentioned Chinese medicine composition as preparation made from Pharmaceutical ingredients.Specifically,
Chinese materia medica preparation of the invention contains above-mentioned Chinese medicine composition, especially containing using Chinese medicine group made from preparation method of the invention
Object is closed, other Pharmaceutical ingredients can be contained or not contain, and contain pharmaceutically acceptable auxiliary material.In the present invention, the pharmacy
Above acceptable auxiliary material can be those of known in field, including but not limited to starch, Icing Sugar, dextrin, lactose, microcrystalline cellulose
Element, mannitol, water, vegetable oil etc..Pharmaceutical preparation form of the invention is not particularly limited.
According to embodiment of the present invention, the Chinese materia medica preparation is medicinal tea, such as by emblic, Radix Astragali, fructus lycii
Son be pulverized and mixed after by enclosed tea bag is measured, the antifatigue medicinal tea of tea bag form is made.
According to another implementation of the invention, the Chinese materia medica preparation be granule, tablet (including lozenge, chewing
Piece), pill (including dripping pill) or capsule, Chinese medicine composition therein can use form of extract, for example, by using the present invention
Water extraction method or the Chinese medicine composition that is prepared of ethanol water extraction method.
Another embodiment according to the present invention, Chinese materia medica preparation of the invention be beverage, decoction, oral solution, mixture or
Form of extract can be used in syrup, Chinese medicine composition therein, mentions for example, by using water extraction method or ethanol water of the invention
Follow the example of the Chinese medicine composition being prepared.
<pharmaceutical applications>
The drug or health food that Chinese medicine composition of the invention can be used for preparing prevention or relieve fatigue, are especially used for
Preparation prevention or the drug or health food for alleviating the fatigue under hypobaric.Confirmed by effect experiment, using emblic,
Radix Astragali and fructus lycii are as bulk pharmaceutical chemicals, and the Chinese medicine composition being prepared using weight proportion of the invention, have significant
Antifatigue effect has significant antifatigue effect, hence it is evident that be used alone better than three especially under hypobaric.Separately
Outside, enter the crowd on plateau for the first time by taking Chinese medicine composition of the invention, to the tolerance degree of plateau low pressure environment
It is apparently higher than the crowd not taken drugs.
The present invention is further illustrated combined with specific embodiments below, but protection scope of the present invention is not limited to
This.
Embodiment 1
37.5 parts by weight of emblic are taken, 25 parts by weight of 37.5 parts by weight of Radix Astragali and fructus lycii ultrasonic extraction 3 times, add every time
The concentration for entering 13 times of amounts of bulk pharmaceutical chemicals total weight is 55vol% ethanol water, extracts 40min every time, is filtered, and filtrate merges,
Rotary evaporation concentration.
Embodiment 2
37.5 parts by weight of emblic are taken, 25 parts by weight of 37.5 parts by weight of Radix Astragali and fructus lycii heat after soaking in water 30min
Refluxing extraction 2 times, each amount of water is 10 times of amounts of bulk pharmaceutical chemicals total weight, and each extraction time is 2 hours, filtering, filtrate
Merge, rotary evaporation concentration.
Embodiment 3
25 parts by weight of emblic are taken, 15 parts by weight of 30 parts by weight of Radix Astragali and fructus lycii ultrasonic extraction 3 times, are added former every time
The ethanol water that the concentration of 8 times of amounts of material medicine total weight are 70vol%, the 1st extraction 1 hour, the 2nd, 3 extraction every time
40min, filtering, filtrate merge, concentration.
Embodiment 4
30 parts by weight of emblic are taken, 18 parts by weight of 40 parts by weight of Radix Astragali and fructus lycii heating and refluxing extraction 3 times, add every time
The concentration for entering 10 times of amounts of bulk pharmaceutical chemicals total weight is the ethanol water of 70vol%, extracts 50min every time, filters, filtrate is closed
And it is concentrated.
Embodiment 5
Take 20 parts by weight of emblic, 10 parts by weight of 50 parts by weight of Radix Astragali and fructus lycii, using 20 times of bulk pharmaceutical chemicals total weight
It measures the ethanol water percolation that concentration is 70vol% to extract 6 hours, percolate is concentrated.
Embodiment 6
30 parts by weight of emblic, 35 parts by weight of Radix Astragali are taken, 25 parts by weight of fructus lycii are crushed to 24 mesh respectively, it is uniformly mixed,
Obtain Chinese medicine composition of the invention.
Embodiment 7
32.5 parts by weight of emblic are taken, 20 parts by weight of 37.5 parts by weight of Radix Astragali and fructus lycii add water heating and refluxing extraction 3
It is secondary, 15 times of amount water of bulk pharmaceutical chemicals total weight are added every time, extract 1 hour every time, filtering, filtrate merges；The filtrate is concentrated.
Embodiment 8
The Chinese medicine composition of embodiment 7 is dry, crushing, then weighs 18 parts by weight, and 82 weight of soluble starch is added
Part, then plus wetting agent microcrystalline cellulose and appropriate lactose are uniformly mixed, and 80 DEG C or less heated-air dryings remove a small amount of moisture,
Softwood is made in (90vol% ethanol water), wet grain is made with squash type pelletizer, granule is made in dry whole grain.
Embodiment 9
The Chinese medicine composition of embodiment 3 is dry, crushing, then weighs 20 parts by weight, and 80 parts by weight of sterile water are added, fill
Divide dissolution, add the Tween-80 of 1.0wt%, the potassium sorbate of 0.15wt% and appropriate stevioside, be uniformly mixed, filters, system
At oral solution.
Embodiment 10
The Chinese medicine composition of embodiment 6 is enclosed into tea pouch, obtains bag tea agent.
Specific effect experiment below proves that pharmaceutical composition of the invention has antifatigue effect.
<experimental animal, drug and environment>
Experimental animal, drug and the simulation environment under low pressure used in mouse swimming test is specific as follows:
Experimental animal:
Below in experiment, for healthy kunming mice, LAF/SPF rank, 18~22g of weight is reached the mouse used by Chengdu
Large Biotechnology Co., Ltd provides.Experimental situation are as follows: 24 ± 0.5 DEG C of temperature, humidity is maintained at 60 ± 2%, room light line traffic control
For system in normal circadian rhythm (bright light when morning 8), animal freely obtains food and water.
Experimental drug:
(1) the traditional chinese medicine composition of the invention 1: the parts by weight of embodiment 1 are operated in grams, obtain concentrate,
Then take the 3/5 of the concentrate, with distilled water be settled to 200ml to get.
(2) the traditional chinese medicine composition of the invention 2: the parts by weight of embodiment 2 are operated in grams, obtain concentrate,
Then take the 3/5 of the concentrate, with distilled water be settled to 200ml to get.
(3) emblic extracting solution: taking emblic 60g, soaks in water after 30min heating and refluxing extraction 2 times, and each adds water
Amount is 600ml, and 2 hours each extraction times filtered, and filtrate merges, and rotary evaporation concentration is settled to 200ml with distilled water, i.e.,
?.
(4) Radix Astragali extractive solution: taking Radix Astragali 60g, soaks in water after 30min heating and refluxing extraction 2 times, and each amount of water is
600ml, 2 hours each extraction times, filtering, filtrate merge, rotary evaporation concentration, with distilled water be settled to 200ml to get.
(5) medlar extract liquid: taking fructus lycii 60g, soaks in water after 30min heating and refluxing extraction 2 times, and each adds water
Amount is 600ml, and 2 hours each extraction times filtered, and filtrate merges, and rotary evaporation concentration is settled to 200ml with distilled water, i.e.,
?.
Experimental situation:
It simulates environment under low pressure: using the vacuum desiccator of top tool rubber stopper, rubber stopper makes a call to two holes, and a hole passes through rubber
Sebific duct connects vacuum pump, and another hole connects air by rubber tube, controls air output by pipe clamp, pumping makes vacuum list index
Reaching 0.03~0.035mPa and balance is standard, with environment under low pressure caused by this simulated high altitude environment under low pressure or other reasons.
<mouse forced swimming>
1. experimental method
Kunming mice 70 are taken, is randomly divided into 7 groups, every group 10, each group is as follows:
Normal pressure blank control group: under atmospheric pressure environment, daily stomach-filling 20ml/kg physiological saline；
Low pressure+blank control group: under environment under low pressure, daily stomach-filling 20ml/kg physiological saline；
1 group of low pressure+the traditional chinese medicine composition of the invention (referred to as 1 group of the present invention): under environment under low pressure, daily stomach-filling 20ml/kg sheet
Invention Chinese medicine composition 1；
2 groups of low pressure+the traditional chinese medicine composition of the invention (referred to as 2 groups of the present invention): under environment under low pressure, daily stomach-filling 20ml/kg sheet
Invention Chinese medicine composition 2；
Low pressure+emblic subgroup: under environment under low pressure, daily stomach-filling 20ml/kg emblic extracting solution；
Low pressure+Radix Astragali group: under environment under low pressure, daily stomach-filling 20ml/kg Radix Astragali extractive solution；
Low pressure+fructus lycii subgroup: under environment under low pressure, daily stomach-filling 20ml/kg medlar extract liquid.
Above-mentioned intragastric administration on mice dosage 20ml/kg converts into 6g/kg, i.e. the crude drug amount of the every kg weight administration of mouse is 6g.Folding
Synthesis people's dosage is 24g/50kg, i.e., the crude drug amount of the administration of the every 50kg weight of people is 24g.
After the daily stomach-filling of each group, in addition to normal pressure blank control group, other each groups are placed in simulation environment under low pressure and raise, the
It presses above-mentioned dosage gastric infusion within 3 days, after 60min is administered, mouse is placed in environment under low pressure in the 1000ml beaker for filling water, bear
The lead of weight own body weight 5%, water temperature are room temperature, carry out swimming test.Emersion water is unable within 10 seconds with head whole submerged
Face is that power exhausts state, and the time that record each group exhausts state to power from swim as mouse swimming time, takes in each group
Average value.
2. experimental result
Experimental result is as shown in table 1.
1 low pressure mouse anti-reflecting fatigue Effect study experimental result of table
Note: compared with low pressure blank group, * P < 0.05**P < 0.01；
Compared with 1 group of the present invention, △ P < 0.05, △ △ P < 0.01.
By experimental data statistical result it is found that compared with low pressure blank group, the mouse of each administration group and normal pressure blank group is swum
The swimming time has extremely significant property to improve (P < 0.01)；The mouse swimming time of emblic subgroup, Radix Astragali group and fructus lycii subgroup is significant
Lower than 1 group (P < 0.05) of the present invention；There was no significant difference with 2 groups of mouse swimming time of the invention by 1 group of the present invention.
Present invention is not limited to the embodiments described above, without departing from the essence of the present invention, this field skill
Any deformation, improvement, the replacement that art personnel are contemplated that each fall within the scope of the present invention.
Claims (4)
1. a kind of antifatigue Chinese medicine composition, which is characterized in that the composition is made of the following raw material medicine: emblic 37.5
Parts by weight, 25 parts by weight of 37.5 parts by weight of Radix Astragali and fructus lycii；
The Chinese medicine composition is made by the steps:
(1) emblic, Radix Astragali and fructus lycii are heated to reflux or ultrasonic extraction 1~5 time, are added are based on emblic, Radix Astragali every time
The ethanol water that concentration with 1~20 times of amount of fructus lycii total weight is 20~100vol%, is extracted 0.5~5 hour every time,
Filtering, filtrate is merged；
(2) filtrate is concentrated.
2. the preparation method of Chinese medicine composition according to claim 1, which comprises the steps of:
(1) emblic, Radix Astragali and fructus lycii are heated to reflux or ultrasonic extraction 1~5 time, are added are based on emblic, Radix Astragali every time
The ethanol water that concentration with 1~20 times of amount of fructus lycii total weight is 20~100vol%, is extracted 0.5~5 hour every time,
Filtering, filtrate is merged；
(2) filtrate is concentrated.
3. a kind of antifatigue Chinese materia medica preparation, which is characterized in that the Chinese materia medica preparation includes Chinese medicine group described in claim 1
Object is closed, and includes pharmaceutically acceptable auxiliary material.
4. the purposes that Chinese medicine composition described in claim 1 is used to prepare prevention or the drug or health food that relieve fatigue.
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| CN111298020B (en) * | 2020-03-31 | 2021-12-17 | 刘敏如女科医系研究院(深圳)有限公司 | Traditional Chinese medicine composition with anti-fatigue effect and preparation method and application thereof |
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| CN102940733A (en) * | 2012-09-03 | 2013-02-27 | 吉林一正药业集团有限公司 | Composition for relieving physical fatigue and preparation method and application thereof |
Non-Patent Citations (2)
| Title |
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| 余甘子抗脑缺氧作用及对低压运动后血清抗氧化物质的影响;聂东 等;《中药材》;20140831;第37卷(第8期);第1448-1452页 * |
| 余甘子果实化学成分及现代药理研究进展;聂东 等;《绵阳师范学院学报》;20121130;第31卷(第11期);第61-66页 * |
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