CN104840746B - A kind of Chinese medicine composition with anti-lung cancer activity and its preparation method and application - Google Patents
A kind of Chinese medicine composition with anti-lung cancer activity and its preparation method and application Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine composition with anti-lung cancer activity and preparation method thereof and its application, the Traditional Chinese medicine compound composition is by 12~36 parts of radix glehniae, 10~30 parts of the tuber of dwarf lilyturf, 20~60 parts of oldenlandia diffusa, 15~45 parts of edible tulip, 15~45 parts of radix ranunculi ternati, fry 10 ~ 30 parts of cattail pollen and be made.Show through pharmacological evaluation and clinical trial, Chinese medicine composition provided by the invention with anti-lung cancer activity, match scientific and reasonable, with anticancer removing toxic substances, dissipating phlegm and removing blood stasis, supplementing qi and nourishing yin and other effects, there is strong killing action to lung carcinoma cell, and the generation of TNF can be promoted, improve tumor patient immunity, and it is safe, toxic side effect is low.Preparation method provided by the invention, steady quality, effective component extracting content is high, workable, is adapted to industrialized production.
Description
Technical field
The present invention relates to a kind of Chinese medicine, and in particular to a kind of Chinese medicine composition with anti-lung cancer activity and preparation method thereof
And application.
Background technology
Tumour has turned into the number one killer for 21 century threatening human survival, has more than 600 ten thousand people to die from every year on average various swollen
Knurl disease.China is one of world's cancer country occurred frequently, and is presented a rapidly rising trend every year.
With environmental pollution getting worse, air pollution is important pollution, and air pollution causes Lung Cancer With High Incidence.Clinically
The medicine that treatment tumour includes lung cancer at present is mainly chemicals, but because chemotherapeutics toxicity is big, is killing tumour cell
While also human autoimmune's cell such as the kill leucocyte of non-selectivity, lymphocyte, cause patient usually due to because from
Body immunocompetence is lowly complicated by infection, and patient uses erious adverse reaction, and the course for the treatment of is grown, costly, has in Clinical practice larger
Limitation.
Traditional Chinese medicine has unique advantage in terms of tumour is treated, and the natural class medicine using Chinese medicine as representative has poison is secondary to make
With the features such as small, action target spot is various, better tolerance, more and more it is taken seriously in terms of tumour is treated.But report at present
Antineoplastic dosage is larger, and impurity component is more, works slower.
Therefore, it is good to research and develop a kind of antitumous effect, dosage is few, has good therapeutic effect to lung cancer, and
The low antineoplastic Chinese traditional medicine of adverse reaction is significant.
The content of the invention
Goal of the invention：Present invention aims to solve the deficiencies of the prior art, and provides a kind of one kind proportioning it is scientific and reasonable, curative effect is true
Cut, Clinical practice safety, the low Chinese medicine composition with anti-lung cancer activity of adverse reaction, another object of the present invention is to provide
This has the preparation method of the Chinese medicine composition of anti-lung cancer activity and its is preparing the application in treating lung cancer disease medicament.
Technical scheme：In order to realize the above object the technical scheme that the present invention takes is：
A kind of Chinese medicine composition with anti-lung cancer activity, it is made up of the bulk drug of following parts by weight：
12~36 parts of radix glehniae, 10~30 parts of the tuber of dwarf lilyturf, 20~60 parts of oldenlandia diffusa, 15~45 parts of edible tulip, radix ranunculi ternati
15~45 parts, fry 10~30 parts of cattail pollen.
Preferably, the above-described Chinese medicine composition with anti-lung cancer activity, it is by following parts by weight
Bulk drug is made：12~24 parts of radix glehniae, 10~20 parts of the tuber of dwarf lilyturf, 20~40 parts of oldenlandia diffusa, 15~30 parts of edible tulip, ram's horn
15~30 parts of grass, fry 10~20 parts of cattail pollen.
Preferably, the above-described Chinese medicine composition with anti-lung cancer activity, it is by following parts by weight
Bulk drug is made：12 parts of radix glehniae, 10 parts of the tuber of dwarf lilyturf, 20 parts of oldenlandia diffusa, 15 parts of edible tulip, 15 parts of radix ranunculi ternati, fry cattail pollen 10
Part.
Preferably, the above-described Chinese medicine composition with anti-lung cancer activity, by the extract of each bulk drug
The medicine of oral liquid, granule, capsule or Tabules is prepared into pharmaceutically acceptable carrier.
The preparation method of Chinese medicine composition of the present invention with anti-lung cancer activity, it comprises the following steps：
(1) oldenlandia diffusa is taken in parts by weight, edible tulip, radix ranunculi ternati, is fried cattail pollen, is added total 6~15 times of medicinal material weight
60~85% ethanol of volume, backflow or continuous circumfluence extraction 2~3 times, 1~3 hour every time, merge extract solution, 50~
It is concentrated under reduced pressure under 70 degrees Celsius, obtains large pore resin absorption column on concentrate, be first eluted with water, be then with volumetric concentration successively
20%~70% ethanol elution；The ethanol eluate for merging that volumetric concentration is 60% is collected, is concentrated to give extract；
(2) radix glehniae and the tuber of dwarf lilyturf are taken in parts by weight, adds total 8~12 times of water of medicinal material weight, soaks 24~48 hours, so
Heating decocts 2~3 times afterwards, 1~3 hour every time, merges and decocts extract solution, add extracting n-butyl alcohol 2~3 times, takes n-butanol to extract
Take liquid to concentrate, obtain extract；
(3) it is prepared by the extract for taking step (1) to obtain, the extract and pharmaceutically acceptable carrier that step (2) obtains
Into the medicine of oral liquid, granule, capsule or Tabules.
Preferably, the preparation method of the above-described Chinese medicine composition with anti-lung cancer activity, step (1) institute
The macroporous absorbent resin stated is D101 resins.
Application of the Chinese medicine composition of the present invention with anti-lung cancer activity in anti-lung-cancer medicament is prepared.
When the extract of each raw material of Chinese medicine composition provided by the invention with anti-lung cancer activity is made into oral liquid,
Add distilled water to dissolve the extract of each raw material, filter, add syrup, adjust pH value, oral liquid is made.
When the extract of each raw material of Chinese medicine composition provided by the invention with anti-lung cancer activity is made into tablet,
The extract and lactose or cornstarch of each raw material, it is necessary to when add magnesium stearate lubricant, be well mixed, whole grain, then press
Tablet is made in piece.
Handle when capsule is made in the extract of each raw material of Chinese medicine composition provided by the invention with anti-lung cancer activity
The extract and carrier lactose or cornstarch of each raw material are well mixed, and whole grain is then encapsulated that capsule is made.
When granule is made in the extract of each raw material of Chinese medicine composition provided by the invention with anti-lung cancer activity,
The extract and diluent lactose or cornstarch of each raw material are well mixed, whole grain, dry, granule is made.
Preferably, the preparation method of the above-described Chinese medicine composition with anti-lung cancer activity, step (1) institute
The macroporous absorbent resin stated is D101 resins.
Application of the Chinese medicine composition of the present invention with anti-lung cancer activity in antineoplastic is prepared.
Chinese medicine composition provided by the invention with anti-lung cancer activity, radix glehniae are sweet；It is cool in nature.Channel tropism：Return lung passes through；Stomach
Through.With nourishiing yin to clear away the lung-heat；Reinforcing stomach reg fluid acts on, and has treatment dryness of the lung dry cough；Consumptive disease is coughed blood；Stomach level deficiency；Tianjin wound does effect.
The tuber of dwarf lilyturf sweet slight bitter, tremble with fear, enter lung channel, stomach, the heart channel of Hang-Shaoyin.With Yin nourishing and lung moistening, relieving restlessness that clears away heart-fire, reinforcing stomach reg fluid effect, tool
There is treatment dryness of the lung dry cough, spit blood, spitting of blood, consumptive lung disease, lung carbuncle, consumptive disease dysphoria with smothery sensation, quench one's thirst, pyreticosis Tianjin wound, dry throat, constipation effect.
Oldenlandia diffusa bitter sweet, tremble with fear.Enter the heart channel of Hang-Shaoyin, Liver Channel, the spleen channel.With clearing heat and detoxicating；Dampness removing acts on, and has treatment lung heat
Breath with cough；Abscess of throat；Acute appendicitis；Furuncle sore；Venomous snake bite；Puckery pain of heat gonorrhea；Oedema；Dysentery；Enteritis；Jaundice with damp-heat pathogen；Cancerous swelling work(
Effect.
Edible tulip nature and flavor：It is sweet；Micro-pungent；It is cold in nature；Return liver warp；Stomach；Lung channel.With clearing heat and detoxicating；Dispersing swelling and dissipating binds act on,
With treatment ulcer malignant sore；Scrofula tuberculosis；Pharyngalgia larynx numbness effect.
Radix ranunculi ternati nature and flavor：Sweet, acrid, warm.Channel tropism：Return liver warp, lung channel.With dissipating bind, detumescence effect.Cure mainly scrofula, lymph
Knot tuberculosis is not burst, pulmonary tuberculosis, scrofula, lymphnoditis, sphagitis.
It is sweet to fry cattail pollen, puts down, enter liver, the heart channel of Hang-Shaoyin, there is cooling blood and hemostasis, activating blood circulation and dissipating blood stasis effect.
Above all medicines share has good anticancer removing toxic substances, dissipating phlegm and removing blood stasis, supplementing qi and nourishing yin and other effects.
Beneficial effect：Chinese medicine composition provided by the invention with anti-lung cancer activity is compared to the prior art with following
Advantage：
1st, for the present invention according to traditional Chinese medical theory, theoretical using diagnosis and treatment carries out Chinese prescription screening, there is provided have
The Chinese medicine composition proportioning of anti-lung cancer activity is scientific and reasonable, has the work(such as good anticancer removing toxic substances, dissipating phlegm and removing blood stasis, supplementing qi and nourishing yin
Effect.Test result indicates that the Chinese medicine composition provided by the invention with anti-lung cancer activity suppresses lung carcinoma cell with good
Growth and the effect that apoptosis of tumor cells can be promoted.
2nd, test result indicates that the Chinese medicine composition provided by the invention with anti-lung cancer activity is with righting reinforcing and exempts from
Epidemic disease function facilitation, and cAMP contents and the generation for promoting TNF (INF) in adjustable body, play Mutiple Targets,
Multiple organ treats the effect of tumour, can reduce tumor patient pain, extend life cycle, improves the effect of life in patients, and
Show that the Chinese medicine composition provided by the invention with anti-lung cancer activity is safe, and toxic side effect is low through long-term experiment research.
3rd, the extract of the Chinese medicine composition provided by the invention with anti-lung cancer activity can conveniently and pharmaceutical carriers system
It is standby into a variety of formulations, it is clinically convenient to take；The preparation of Chinese medicine composition provided by the invention with anti-lung cancer activity simultaneously
Method, it is workable, design extraction and purification process, obtained extraction especially in accordance with each herbal medicine active ingredient chemical property
Thing active constituent content is high, and impurity is few, and has the advantages that absorption is fast, can play drug effect rapidly, and clinically dosage is few, and work
Skill is stable, is adapted to industrialized production.
Embodiment：
With reference to specific embodiment, the present invention is furture elucidated, it should be understood that these embodiments be merely to illustrate the present invention and
Limitation the scope of the present invention is not used in, after the present invention has been read, various of equal value shapes of the those skilled in the art to the present invention
The modification of formula falls within the application appended claims limited range.
Implementation column 1
1. a kind of Chinese medicine composition with anti-lung cancer activity, it is made up of the bulk drug of following parts by weight：Radix glehniae
12 grams, 10 grams of the tuber of dwarf lilyturf, 20 grams of oldenlandia diffusa, 15 grams of edible tulip, 15 grams of radix ranunculi ternati, fry 10 grams of cattail pollen.
2. the preparation method of the Chinese medicine composition of the present invention with anti-lung cancer activity, it comprises the following steps：
(1) 20 grams of oldenlandia diffusa is taken in parts by weight, 15 grams of edible tulip, 15 grams of radix ranunculi ternati, fries 10 grams of cattail pollen, is added total
75% ethanol of 10 times of volumes of medicinal material weight, backflow or continuous circumfluence extraction 3 times, 2 hours every time, merge extract solution, 50
It is concentrated under reduced pressure under~70 degrees Celsius, obtains large pore resin absorption column on concentrate, be first eluted with water, be then with volumetric concentration successively
20%~70% ethanol elution；The ethanol eluate for merging that volumetric concentration is 60% is collected, is concentrated to give extract；
(2) take 12 grams of radix glehniae in parts by weight, 10 grams of the tuber of dwarf lilyturf, add total 10 times of water of medicinal material weight, soak 48 hours, so
Heating decocts 2 times afterwards, 3 hours every time, merges and decocts extract solution, add extracting n-butyl alcohol 3 times, takes butanol extraction liquid to concentrate,
Obtain extract；
(3) extract for taking step (1) to obtain, the extract that step (2) obtains add lactose, and cornstarch mixing is equal
It is even, magnesium stearate lubricant is added, is well mixed, tablet is made in whole grain, then tabletting.(lot number：001)
Implementation column 2
1. a kind of Chinese medicine composition with anti-lung cancer activity, it is made up of the bulk drug of following parts by weight：Radix glehniae
24 grams, 20 grams of the tuber of dwarf lilyturf, 40 grams of oldenlandia diffusa, 30 grams of edible tulip, 30 grams of radix ranunculi ternati, fry 20 grams of cattail pollen.
2. the preparation method of the Chinese medicine composition of the present invention with anti-lung cancer activity, it comprises the following steps：
(1) 40 grams of oldenlandia diffusa is taken in parts by weight, 30 grams of edible tulip, 30 grams of radix ranunculi ternati, fries 20 grams of cattail pollen, is added total
60% ethanol of 12 times of volumes of medicinal material weight, backflow or continuous circumfluence extraction 2 times, 3 hours every time, merge extract solution, 50
It is concentrated under reduced pressure under~70 degrees Celsius, obtains large pore resin absorption column on concentrate, be first eluted with water, be then with volumetric concentration successively
20%~70% ethanol elution；The ethanol eluate for merging that volumetric concentration is 60% is collected, is concentrated to give extract；
(2) take 24 grams of radix glehniae in parts by weight, 20 grams of the tuber of dwarf lilyturf, add total 12 times of water of medicinal material weight, soak 24 hours, so
Heating decocts 3 times afterwards, 2 hours every time, merges and decocts extract solution, add extracting n-butyl alcohol 2 times, takes butanol extraction liquid to concentrate,
Obtain extract；
(3) extract for taking step (1) to obtain, the extract that step (2) obtains, diluent lactose or corn are then added
Starch is well mixed, whole grain, dries, granule is made.(lot number：002)
Implementation column 3
1. a kind of Chinese medicine composition with anti-lung cancer activity, it is made up of the bulk drug of following parts by weight：Radix glehniae
36 grams, 30 grams of the tuber of dwarf lilyturf, 60 grams of oldenlandia diffusa, 45 grams of edible tulip, 45 grams of radix ranunculi ternati, fry 30 grams of cattail pollen.
2. the preparation method of the Chinese medicine composition of the present invention with anti-lung cancer activity, it comprises the following steps：
(1) 60 grams of oldenlandia diffusa is taken in parts by weight, 45 grams of edible tulip, 45 grams of radix ranunculi ternati, fries 30 grams of cattail pollen, is added total
50% ethanol of 15 times of volumes of medicinal material weight, backflow or continuous circumfluence extraction 2 times, 2 hours every time, merge extract solution, 50
It is concentrated under reduced pressure under~70 degrees Celsius, obtains large pore resin absorption column on concentrate, be first eluted with water, be then with volumetric concentration successively
20%~70% ethanol elution；The ethanol eluate for merging that volumetric concentration is 60% is collected, is concentrated to give extract；
(2) take 36 grams of radix glehniae in parts by weight, 30 grams of the tuber of dwarf lilyturf, add total 8 times of water of medicinal material weight, soak 48 hours, so
Heating decocts 2 times afterwards, 2 hours every time, merges and decocts extract solution, add extracting n-butyl alcohol 2 times, takes butanol extraction liquid to concentrate,
Obtain extract；
(3) extract for taking step (1) to obtain, the extract that step (2) obtains, then mixed with lactose, cornstarch
With whole grain is then encapsulated that capsule is made.(lot number：003)
Implementation column 4 has experimental study of the Chinese medicine composition to human tumour inhibitory action in nude mouse of anti-lung cancer activity
(1) to the inhibitory action of lung cancer in nude mouse (MCF-7) cell
Experimental method：Lung cancer (MCF-7) cell suspension is prepared, adjusts cell concentration, often armpit subcutaneous vaccination MCF-7 before the mouse right side
Cell 5 × 106Individual/0.2ml, 20 are inoculated with altogether, is randomly divided into treatment group's (Chinese medicine provided by the invention with anti-lung cancer activity
Composition, the gastric infusion of lot number 001., 2g/kg) and blank group (waiting capacity physiological saline), after every group 10,24 hours, start
Medication, once a day, continuous 24 days, after drug withdrawal, animal is put to death, tumour growth situation is observed and takes tumor tissue and weigh, specifically
Experimental result is shown in Table 1.
Inhibitory action of the table 1 to lung cancer in nude mouse (MCF-7) cell
By more than test result indicates that：Chinese medicine composition provided by the invention with anti-lung cancer activity is to human lung cancer nude mice
In vivo transplanting there is obvious inhibitory action, show in the Chinese medicine composition body provided by the invention with anti-lung cancer activity with
The effect of very strong anti-lung cancer, it can be used for the treatment of lung cancer disease.
Implementation column 5 has experiment of the Chinese medicine composition of anti-lung cancer activity to immunoregulation effect
(1) to the influence of mouse IgA, IgG, IgM content
Experimental method：Take ICR small white mouses 30,18~22g of body weight, be randomly divided into Normal group, lotus knurl control group and
Treatment group, traditional vaccination lung carcinoma cell, 24 hours after inoculation, treatment group, which gavages the present invention, has the Chinese traditional medicine composition of anti-lung cancer activity
Thing (lot number 001) 0.3ml/ only (2g/kg), take a blood sample within the 15th day by small white mouse eyeball.Determine IgA, IgG, IgM content, specific experiment
It the results are shown in Table 2.
Influence (mg/dl of the table 2 to mouse IgA, IgG, IgM content)
*P<0.01 (compared with Normal group) * * P<0.05 (compared with lotus knurl control group)
By with upper table 2 test result indicates that：The mouse of lung cancer is inoculated with, Immunoglobulin IgA, IgG, IgM content are obvious
Less than normal control mice；The present invention have anti-lung cancer activity Chinese medicine composition can improve the low IgA of mouse,
IgG, IgM content, show the Chinese medicine composition provided by the invention with anti-lung cancer activity with immunologic enhancement, Ke Yiti
The high tumor patient immunologic function of itself, so as to be advantageous to improve Quality of Life of Tumor Patients and promote itself antitumor action.
(2) the raising effect induced to TNF (INF)
Experimental method：Wistar big white mouse 20 are taken, are randomly divided into control group and treatment group, every animal is injected intraperitoneally
10mg BCG vaccines, the μ gLPS of intraperitoneal injection in the 15th day 80, take a blood sample after 90 minutes.Treatment group gavages the present invention, and there is anti-lung cancer to live
Property Chinese medicine composition 2ml/ only (lot number 001,2g/kg), continuous 14 days, control group such as gavaged at the capacity physiological saline.
Test serum is taken, is diluted to various concentrations；Target cell L929 is adjusted with 10% calf serum, RPM1-1640 nutrient solutions
Whole is 2 × 106/ml cells, is added in 96 porocyte culture plates；100 μ l/ holes, then add the test serum 100 of different extension rates
μ l/ holes；37 DEG C are put, 5%CO2Cultivated 18 hours in incubator.Result judgement：With the maximum dilution multiple of 50% target cell death
For INF potency.Concrete outcome is shown in Table 3.
The facilitation that table 3 induces to rat INF
*P<0.001 (compared with Normal group)
By table 3 test result indicates that：Chinese medicine composition provided by the invention with anti-lung cancer activity can be obviously promoted
INF's induces, (P<0.001), illustrate that the Chinese medicine composition provided by the invention with anti-lung cancer activity can pass through induced tumors
Necrosin INF reaches antitumor purpose.
Test result indicates that, the Chinese medicine composition provided by the invention with anti-lung cancer activity is to tumor patient more than
Immunologic function has raising effect, and can promote TNF (INF) generation, can strengthen the antitumor work(of patient itself
Energy.
Embodiment 6
Chinese medicine composition clinical test results provided by the invention with anti-lung cancer activity are shown：To lung cancer chemotherapy patient
40, the Chinese medicine composition (embodiment of the present invention 1) provided by the present invention with anti-lung cancer activity is taken, was faced through 2 months
Bed observation, the tumor patient of Traditional Chinese medicine compound composition provided by the invention is taken, clinical symptoms, which have, to be obviously improved, patients with lung cancer
Quality of life is improved, and toxicity substantially mitigates caused by chemotherapy, is shown provided by the present invention with anti-lung cancer work
Property Chinese medicine composition have the function that to protect and improve to immunologic function, and human peripheral blood is as with protective effect, clinic is seen
It is 80.2% to survey efficient.
The present invention carries out proportioning prescription using the theory of diagnosis and treatment, passes through above experimental result according to traditional Chinese medical theory
Show, the Chinese medicine composition provided by the invention with anti-lung cancer activity is with work(such as anticancer removing toxic substances, dissipating phlegm and removing blood stasis, supplementing qi and nourishing yins
Effect, there is the growth and transferance for suppressing lung cancer tumor, and without obvious toxic-side effects, illustrate provided by the invention there is anti-lung
The Chinese medicine composition of cancer activity can be used for the medicine for preparing anti-lung cancer.
Described above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, under the premise without departing from the principles of the invention, some improvements and modifications can also be made, these improvements and modifications also should
It is considered as protection scope of the present invention.
Claims (7)
1. a kind of Chinese medicine composition with anti-lung cancer activity, it is characterised in that it is made up of the bulk drug of following parts by weight：
12~36 parts of radix glehniae, 10~30 parts of the tuber of dwarf lilyturf, 20~60 parts of oldenlandia diffusa, 15~45 parts of edible tulip, radix ranunculi ternati 15~
45 parts, fry 10 ~ 30 parts of cattail pollen.
2. the Chinese medicine composition according to claim 1 with anti-lung cancer activity, it is characterised in that it is by following parts by weight
Several bulk drugs are made：12~24 parts of radix glehniae, 10~20 parts of the tuber of dwarf lilyturf, 20~40 parts of oldenlandia diffusa, 15~30 parts of edible tulip,
15~30 parts of radix ranunculi ternati, fry 10 ~ 20 parts of cattail pollen.
3. the Chinese medicine composition according to claim 2 with anti-lung cancer activity, it is characterised in that it is by following parts by weight
Several bulk drugs are made：12 parts of radix glehniae, 10 parts of the tuber of dwarf lilyturf, 20 parts of oldenlandia diffusa, 15 parts of edible tulip, 15 parts of radix ranunculi ternati, fry Pu
It is yellow 10 parts.
4. the Chinese medicine composition with anti-lung cancer activity according to any one of claims 1 to 3, it is characterised in that will be each
The extract and pharmaceutically acceptable carrier of bulk drug are prepared into the medicine of oral liquid, granule, capsule or Tabules.
5. the preparation method of the Chinese medicine composition with anti-lung cancer activity described in any one of claims 1 to 3, it is characterised in that
Comprise the following steps：
(1) parts by weight as described in any one of claims 1 to 3 take oldenlandia diffusa, edible tulip, radix ranunculi ternati, fry cattail pollen, add
Enter 60~85% ethanol of total 6~15 times of volumes of medicinal material weight, backflow or continuous circumfluence extraction 2~3 times, 1 ~ 3 is small every time
When, merge extract solution, be concentrated under reduced pressure under 50~70 degrees Celsius, obtain large pore resin absorption column on concentrate, be first eluted with water, then
It is successively 20%~70% ethanol elution with volumetric concentration；The ethanol eluate for merging that volumetric concentration is 60% is collected, is concentrated to give extraction
Thing；
（2）Parts by weight as described in any one of claims 1 to 3 take radix glehniae and the tuber of dwarf lilyturf, add total 8~12 times of medicinal material weight
Water, soak 24~48 hours, decoct 2~3 times, 1 ~ 3 hour every time, merge and decoct extract solution, add extracting n-butyl alcohol 2~3 times,
Take butanol extraction liquid to concentrate, obtain extract；
(3) extract for taking step (1) to obtain, the extract and pharmaceutically acceptable carrier that step (2) obtains are prepared into mouth
Take the medicine of liquid, granule, capsule or Tabules.
6. the preparation method of the Chinese medicine composition with anti-lung cancer activity described in claim 5, it is characterised in that step（1）
Described macroporous absorbent resin is D101 resins.
7. the Chinese medicine composition with anti-lung cancer activity described in any one of claims 1 to 3 is in anti-lung-cancer medicament is prepared
Using.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1439312A (en) * | 2003-03-28 | 2003-09-03 | 周伟 | Anticancer beverage and preparation thereof |
| CN101912521A (en) * | 2010-07-17 | 2010-12-15 | 苗丽华 | Medicament for treating lung cancer |
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2015
- 2015-05-18 CN CN201510254309.8A patent/CN104840746B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1439312A (en) * | 2003-03-28 | 2003-09-03 | 周伟 | Anticancer beverage and preparation thereof |
| CN101912521A (en) * | 2010-07-17 | 2010-12-15 | 苗丽华 | Medicament for treating lung cancer |
Non-Patent Citations (1)
| Title |
|---|
| 周仲瑛治疗肿瘤的临证思路探析;霍介格等;《上海中医药杂志》;20070131;第41卷(第1期);第6页左栏"5.2肺癌" * |
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