CN103768534B - A kind of Chinese medicine composition with antitumor activity - Google Patents
A kind of Chinese medicine composition with antitumor activity Download PDFInfo
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- CN103768534B CN103768534B CN201410053527.0A CN201410053527A CN103768534B CN 103768534 B CN103768534 B CN 103768534B CN 201410053527 A CN201410053527 A CN 201410053527A CN 103768534 B CN103768534 B CN 103768534B
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Abstract
The invention discloses a kind of Chinese medicine composition with antitumor activity, it is made up of the bulk drug of following parts by weight：30 ~ 60 parts of ginseng, 20 ~ 40 parts of the tuber of dwarf lilyturf, 30 ~ 50 parts of oldenlandia diffusa, 10 ~ 40 parts of Sculellaria barbata, 10 ~ 20 parts of rhizoma arisaematis, 10 ~ 30 parts of curcuma zedoary.The present invention is according to traditional Chinese medical theory, Chinese prescription screening is carried out using the theory of diagnosis and treatment, Chinese medicine composition proportioning is scientific and reasonable, test result indicate that, the Chinese medicine composition that the present invention is provided has suppression growth of tumour cell well and can promote the effect of apoptosis of tumor cells, and strong killing action is respectively provided with to Several Kinds of Malignancy cell, have wide range of applications；Tumor patient pain is can obviously reduce, extends life cycle, improve the effect of life in patients, and show that the Chinese medicine composition that the present invention is provided is safe, and toxic and side effect is low, and it is new antineoplastic that can be developed into through long-term experiment research.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, and in particular to a kind of Chinese medicine composition with antitumor activity, belong to
Medical pharmaceutical technology field.
Background technology
Tumour has turned into the number one killer for 21 century threatening human survival, has more than 600 ten thousand people to die from every year on average various swollen
Knurl disease.China is one of world's cancer country occurred frequently, increases more than 200 ten thousand cancer patients newly every year, accounts for global sum up to 20%,
The people of existing cancer patient more than 400 ten thousand, and present a rapidly rising trend every year.Clinically main the having of medicine for the treatment of tumour at present
Medicine is learned, but because chemotherapeutics toxicity is big, also the kill leucocyte of non-selectivity, lymph are thin while tumour cell is killed
Human autoimmune's cell such as born of the same parents, causes patient usually because because of autoimmunity inferior capabilities accompanying infection, patient uses bad
Reaction is big, and the course for the treatment of is long, costly, there is larger limitation in Clinical practice.
With unique advantage in terms of tumour is treated, the natural class medicine with Chinese medicine as representative has the secondary work of poison to traditional Chinese medicine
With small, action target spot is various, better tolerance the features such as, be more and more taken seriously in terms of tumour is treated.
Therefore, necessary based on traditional Chinese medical theory, a kind of antitumous effect of research and development is good, and adverse reaction is low
Chinese medicine composition.
The content of the invention
Goal of the invention：Present invention aim to address the deficiencies in the prior art, there is provided one kind proportioning is scientific and reasonable, and curative effect is true
Cut, Clinical practice safety, the low Chinese medicine composition with antitumor activity of adverse reaction, another object of the present invention is to provide
This has application of the Chinese medicine composition of antitumor activity in treatment malignancy disease medicine is prepared.
Technical scheme：In order to realize the above object the technical solution used in the present invention is：
A kind of Chinese medicine composition with antitumor activity, it is made up of the bulk drug of following parts by weight：
30~45 parts of ginseng, 30~45 parts of the tuber of dwarf lilyturf, 30~60 parts of oldenlandia diffusa, 30~60 parts of Sculellaria barbata, rhizoma arisaematis 10
~20 parts, 30~45 parts of curcuma zedoary.
Preferably, the above-described Chinese medicine composition with antitumor activity, it is by following parts by weight
Bulk drug is made：30~40 parts of ginseng, 30~40 parts of the tuber of dwarf lilyturf, 40~60 parts of oldenlandia diffusa, 40~60 parts of Sculellaria barbata, rhizoma arisaematis
10~15 parts, 30~40 parts of curcuma zedoary.
Used as more preferably scheme, the above-described Chinese medicine composition with antitumor activity, it is by following parts by weight
Bulk drug be made：30 parts of ginseng, 30 parts of the tuber of dwarf lilyturf, 60 parts of oldenlandia diffusa, 60 parts of Sculellaria barbata, 20 parts of rhizoma arisaematis, 30 parts of curcuma zedoary.
Preferably, the above-described Chinese medicine composition with antitumor activity, described rhizoma arisaematis is day processed
Southern Star.
Chinese medicine composition with antitumor activity of the present invention, can by the extract of each bulk drug and pharmaceutically connect
The carrier received is prepared into the medicine of oral liquid, granule, capsule or tablet.
The extract of each raw material of the Chinese medicine composition with antitumor activity that the present invention provides the present invention is made mouth
When taking liquid, the extract of each raw material is added into distillation water dissolves, filtered, add syrup, adjust pH value, be made oral liquid.
When the extract of each raw material of the Chinese medicine composition with antitumor activity that the present invention is provided is made tablet,
The extract and lactose or cornstarch of each raw material, it is necessary to when add magnesium stearate lubricant, be well mixed, then whole grain presses
Piece is made tablet.
The handle when extract of each raw material of the Chinese medicine composition with antitumor activity that the present invention is provided is made capsule
The extract and carrier lactose or cornstarch of each raw material are well mixed, and whole grain is then encapsulated to be made capsule.
When the extract of each raw material of the Chinese medicine composition with antitumor activity that the present invention is provided is made granule,
The extract and diluent lactose or cornstarch of each raw material are well mixed, whole grain, dry, and are made granule.
Application of the Chinese medicine composition with antitumor activity of the present invention in antineoplastic is prepared.
Preferably, the described Chinese medicine composition with antitumor activity prepare anti-liver cancer and anti-, stomach cancer, lung cancer,
Breast cancer, intestinal cancer, the application in leukemia medicament.
The preparation method of the Chinese medicinal composition preparation with antitumor activity that the present invention is provided, specifically includes following step
Suddenly：
(1) ginseng is taken, 8~15 times of amount water of dosing material, ultrasound or decoction are extracted 3 times, 1~3 hour every time, obtain water extraction
Liquid, concentration, extracting n-butyl alcohol obtains butanol extraction liquid, and upper macroporous resin column is rinsed with water, is then 20~50% with concentration
Ethanol elution, obtains alcohol eluen, vacuum drying, obtains ginseng extract, standby；
(2) tuber of dwarf lilyturf, oldenlandia diffusa, Sculellaria barbata, rhizoma arisaematis, curcuma zedoary, 5~12 times of amount second of concentration 30~80% of dosing material are taken
Alcohol heating and refluxing extraction three times, 1~2 hour every time, merges extract solution, and filtering, filtrate recycling ethanol, concentration is vacuum dried
Extract, it is standby；
(3) extract that the ginseng extract and step (2) that combining step (1) is obtained are obtained, and it is pharmaceutically acceptable
Carrier is prepared into the medicine of oral liquid, granule, capsule or Tabules.
The Chinese medicine composition with antitumor activity that the present invention is provided, oldenlandia diffusa, curcuma zedoary in side, clearing heat and detoxicating,
Dispersing swelling and dissipating binds；Sculellaria barbata, rhizoma arisaematis reducing phlegm and resolving masses, eliminating blood stasis and smoothing collaterals are attacked poison and are disappeared cancer；Ginseng, the tuber of dwarf lilyturf, supplementing qi and nourishing yin, righting toxic removing.
, to the interpretation of the cause, onset and process of an illness of tumour " pent-up of cancer poison, deficiency of YIN leading to consumption of QI " card, tonification and purgation in combination for full policy, and the work(of " removing toxic substances disappear cancer, supplementing qi and nourishing yin " is played altogether,
Clinical efficacy is notable.
Beneficial effect：Compared to the prior art the Chinese medicine composition with antitumor activity that the present invention is provided has following
Advantage：
1st, the present invention according to traditional Chinese medical theory, Chinese prescription screening is carried out using the theory of diagnosis and treatment, there is provided have
The Chinese medicine composition proportioning of antitumor activity is scientific and reasonable, test result indicate that, the present invention provide with antitumor activity
Chinese medicine composition to be had suppress growth of tumour cell well and can promote the effect of apoptosis of tumor cells, and to various pernicious swollen
Oncocyte is respectively provided with strong killing action, has wide range of applications；And test result indicate that the present invention provide with antitumor
The Chinese medicine composition of activity has raising immunity function, can obviously reduce tumor patient pain, extends life cycle, improves and suffers from
The effect of person's life quality, and show through long-term experiment research, the Chinese medicine composition with antitumor activity that the present invention is provided
Safe, toxic and side effect is low.
2nd, the extract of the Chinese medicine composition with antitumor activity that the present invention is provided, can facilitate and pharmaceutical carriers system
It is clinically convenient to take for into various formulations.
Specific embodiment
With reference to specific embodiment, the present invention is furture elucidated, it should be understood that these embodiments be merely to illustrate the present invention and
Limitation the scope of the present invention is not used in, after the present invention has been read, those skilled in the art are to various shapes of equal value of the invention
The modification of formula falls within the application appended claims limited range.
Embodiment 1
1st, the bulk drug composition of the Chinese medicine composition with antitumor activity：
30 parts of ginseng, 30 parts of the tuber of dwarf lilyturf, 30 parts of oldenlandia diffusa, 30 parts of Sculellaria barbata, 10 parts of rhizoma arisaematis, 30 parts of curcuma zedoary.
2nd, the preparation method of the Chinese medicinal composition preparation with antitumor activity：
(1) 30 parts of ginseng is taken, 15 times of amount water of dosing material, ultrasonic extraction 3 times 3 hours every time, obtains Aqueous extracts, concentrates, positive fourth
Alcohol is extracted, and obtains butanol extraction liquid, and upper macroporous resin column is rinsed with water, is then 20~50% ethanol elutions with concentration, obtains alcohol
Eluent, vacuum drying, obtains ginseng extract, standby；
(2) 30 parts of the tuber of dwarf lilyturf, 30 parts of oldenlandia diffusa, 30 parts of Sculellaria barbata, 10 parts of rhizoma arisaematis, 30 parts of curcuma zedoary, dosing material 10 are taken
60% ethanol heating and refluxing extraction of amount concentration three times, 2 hours every time, merges extract solution again, and filtering, filtrate recycling ethanol is concentrated,
Extract is vacuum dried to obtain, it is standby；
(3) extract that the ginseng extract and step (2) that combining step (1) is obtained are obtained, is subsequently adding lactose, corn
Starch is well mixed, and adds magnesium stearate lubricant, is well mixed, whole grain, and then compressing tablet is made tablet.(lot number：001)
Embodiment 2
1st, the bulk drug composition of the Chinese medicine composition with antitumor activity：
45 parts of ginseng, 45 parts of the tuber of dwarf lilyturf, 60 parts of oldenlandia diffusa, 60 parts of Sculellaria barbata, 20 parts of rhizoma arisaematis, 45 parts of curcuma zedoary.
2nd, the preparation method of the Chinese medicinal composition preparation with antitumor activity：
(1) 45 parts of ginseng is taken, 8 times of amount water of dosing material, ultrasound or decoction are extracted 3 times, 2 hours every time, obtain Aqueous extracts, dense
Contracting, extracting n-butyl alcohol obtains butanol extraction liquid, and upper macroporous resin column is rinsed, then with concentration for 20~50% ethanol are washed with water
It is de-, alcohol eluen is obtained, it is vacuum dried, ginseng extract is obtained, it is standby；
(2) 45 parts of the tuber of dwarf lilyturf, 60 parts of oldenlandia diffusa, 60 parts of Sculellaria barbata, 20 parts of rhizoma arisaematis, 45 parts of curcuma zedoary, 8 times of dosing material are taken
70% ethanol heating and refluxing extraction of amount concentration 2 times, 2 hours every time, merges extract solution, and filtering, filtrate recycling ethanol is concentrated, very
Empty dry extract, it is standby；
(3) extract that the ginseng extract and step (2) that combining step (1) is obtained are obtained, is subsequently adding diluent breast
Sugar or cornstarch are well mixed, and whole grain is dried, and is made granule.(lot number：002)
Embodiment 3
1st, the bulk drug composition of the Chinese medicine composition with antitumor activity：
40 parts of ginseng, 40 parts of the tuber of dwarf lilyturf, 60 parts of oldenlandia diffusa, 60 parts of Sculellaria barbata, 15 parts of rhizoma arisaematis, 40 parts of curcuma zedoary.
2nd, the preparation method of the Chinese medicinal composition preparation with antitumor activity：
(1) 40 parts of ginseng is taken, 10 times of amount water of dosing material, ultrasound or decoction are extracted 2 times, 3 hours every time, obtain Aqueous extracts,
Concentration, extracting n-butyl alcohol obtains butanol extraction liquid, and upper macroporous resin column is rinsed with water, is then 20~50% ethanol with concentration
Wash-out, obtains alcohol eluen, is vacuum dried, and obtains ginseng extract, standby；
(2) 40 parts of the tuber of dwarf lilyturf, 60 parts of oldenlandia diffusa, 60 parts of Sculellaria barbata, 15 parts of rhizoma arisaematis, 40 parts of curcuma zedoary are taken.Dosing material 12
70% ethanol heating and refluxing extraction of amount concentration 2 times, 2 hours every time, merges extract solution again, and filtering, filtrate recycling ethanol is concentrated,
Extract is vacuum dried to obtain, it is standby；
(3) extract that the ginseng extract and step (2) that combining step (1) is obtained are obtained and then and lactose, corn forms sediment
Powder mixes with whole grain is then encapsulated to be made capsule.(lot number：003)
Embodiment 4
1st, the bulk drug composition of the Chinese medicine composition with antitumor activity：
30 parts of ginseng, 30 parts of the tuber of dwarf lilyturf, 60 parts of oldenlandia diffusa, 60 parts of Sculellaria barbata, 20 parts of rhizoma arisaematis, 30 parts of curcuma zedoary.
2nd, the preparation method of the Chinese medicinal composition preparation with antitumor activity is with embodiment 2.
The antitumor pharmacological evaluation of embodiment 5
1st, internal anti-tumor experiment
(1) experiment material
Test medicine：The extract of the Chinese medicine composition prepared using the embodiment of the present invention 1.Positive control drug：It is suitable
Platinum.
(2) experimental technique
Experimental animal：Take Kunming mouse, 18~22g of body weight, male and female dual-purpose.
Take the liver cancer H of inoculation 10 days22Tumor mass, is made H22Cell suspension (cell number 1 × 107/ ml), except healthy control group
Outward, the right armpit subcutaneous vaccination liver cancer H of remaining mouse upper limbs22Cell suspension 0.2ml, after being inoculated with 24 hours, is randomly divided into physiological saline
Group 20ml/kg, the Chinese medicinal compound extract group concentration of embodiment 1 are respectively：10g/kg/d, 30g/kg/d and 90g/kg/d, cis-platinum
Positive drug control group 60mg/kg intraperitoneal injections.The equal successive administration of each group 14 days, whole mouse were put to death with the 15th day, were taken tumor mass and were claimed
Weight, calculates apoptosis of tumor cells rate.Specific experiment result is as shown in table 1：
The cell cycle of each group mouse tissue cell of table 1 and apoptosis rate compare (n=10,%)
Note：Compare with model group,★★P<0.01,★P<0.05。
Test result indicate that, compare with control group, the present invention provide each dosage group of Chinese medicine composition and cis-platinum group with it is right
Compared according to group, its transplantable tumor apoptosis rate has significant difference (P<0.05, P<0.01)；Effect with good anti-liver cancer and anti-
Really.And test result indicate that, the Traditional Chinese medicine compound composition that the present invention is provided is in 30g/kg/d and 90g/kg/d dosage groups, cis-platinum
Group mice-transplanted tumor histocyte blocks in G0/G1Phase (P<0.05), S phase cell numbers significantly reduce (P<0.05).
2nd, anticancer experiment in vitro
With human lung cancer (MCF-7), breast cancer (A-5408), human gastric cancer (SGC-7901) and people's casing slime gland cancer 4 kinds of knurls plant,
Anticancer experiment in vitro, the embodiment of the present invention 1, embodiment 2, embodiment 3 and embodiment are carried out using tetrazolium bromide reducing process (MTT)
The extract of 4 Chinese medicine compositions for preparing is test medicine, and with cis-platinum as positive controls, the solvent with sample is physiology
Salt solution is negative control group.Specific experiment result is as shown in table 2：
Inhibitory action (IC of the Chinese medicine composition of table 2 to tumour cell50It is half inhibiting rate)
Shown by the anticancer experiment in vitro result of table 2, the Chinese medicine composition that the present invention is provided is respectively provided with to human tumor cells
Stronger inhibitory action, and found out by experimental result, the Chinese medicine composition that the present invention is provided has compared with comparison medicine cis-platinum
Equal even more excellent antitumous effect.Show the Chinese medicine composition with antitumor activity of present invention offer, with very strong
Anti-human malignant tumour effect, can be used for the treatment of malignancy disease.
The present invention carries out proportioning prescription, by above experimental result according to traditional Chinese medical theory using the theory of diagnosis and treatment
Show, the Chinese medicine composition with antitumor activity that the present invention is provided has clearing heat and detoxicating, the core dissipating bind that disappears, strengthening vital QI to eliminate pathogenic factors, supports
The function of cloudy QI invigorating, has functions that to promote apoptosis of tumor cells well, and the tool provided without obvious toxic-side effects, the present invention
The Chinese medicine composition for having antitumor activity can be used for preparing antineoplastic new medicine.
The above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, under the premise without departing from the principles of the invention, some improvements and modifications can also be made, these improvements and modifications also should
It is considered as protection scope of the present invention.
Claims (3)
1. a kind of Chinese medicine composition with antitumor activity, it is characterised in that it is made up of the bulk drug of following parts by weight：
30~45 parts of ginseng, 30~45 parts of the tuber of dwarf lilyturf, 30~60 parts of oldenlandia diffusa, 30~60 parts of Sculellaria barbata, 10~20 parts of rhizoma arisaematis, cowherb
30~45 parts of art；
Described antitumor activity is the activity of anti-gastric cancer, lung cancer, breast cancer or casing slime gland cancer.
2. the Chinese medicine composition with antitumor activity according to claim 1, it is characterised in that it is by following weight portion
Several bulk drugs are made：30~40 parts of ginseng, 30~40 parts of the tuber of dwarf lilyturf, 40~60 parts of oldenlandia diffusa, Sculellaria barbata 40~60 part, day
10~15 parts of Southern Star, 30~40 parts of curcuma zedoary.
3. the Chinese medicine composition with antitumor activity according to claim 1, it is characterised in that it is by following weight portion
Several bulk drugs are made：30 parts of ginseng, 30 parts of the tuber of dwarf lilyturf, 60 parts of oldenlandia diffusa, 60 parts of Sculellaria barbata, 20 parts of rhizoma arisaematis, curcuma zedoary 30
Part.
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Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104857435B (en) * | 2015-05-18 | 2018-06-26 | 南京中医药大学 | A kind of Traditional Chinese medicine compound composition with antitumor activity and its preparation method and application |
| CN105267509A (en) * | 2015-11-19 | 2016-01-27 | 吴斌 | Drug for treating breast cancer |
| CN105362691A (en) * | 2015-12-02 | 2016-03-02 | 钊桂英 | Traditional Chinese medicine composition mainly for treating leukemia and preparation method |
| CN107029185A (en) * | 2017-05-09 | 2017-08-11 | 张新成 | Chinese medicine composition of prevention and/or treatment tumour and preparation method thereof |
| CN107281376A (en) * | 2017-07-06 | 2017-10-24 | 南京弘典医药科技有限公司 | A kind of snake gourd fruit pulp wets one's whistle composition and preparation method and application |
| CN108853391A (en) * | 2018-08-24 | 2018-11-23 | 刘大秀 | A kind of treat dislikes carcinoid Chinese materia medica preparation and preparation method thereof |
| CN109010774A (en) * | 2018-09-25 | 2018-12-18 | 王召华 | A kind of Chinese medicine composition and preparation method thereof for treating lung cancer |
| CN110193050A (en) * | 2019-07-09 | 2019-09-03 | 河南省中医院（河南中医药大学第二附属医院） | Traditional Chinese medicine composition for preventing recurrence and metastasis of digestive tract tumor and preparation method thereof |
| CN111202830A (en) * | 2020-03-26 | 2020-05-29 | 南京中医药大学 | Compound traditional Chinese medicine for treating non-small cell lung cancer and preparation method thereof |
| CN111773369A (en) * | 2020-08-18 | 2020-10-16 | 梁雪保 | Decoction for conditioning small cell lung cancer and preparation method thereof |
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| CN1164294C (en) * | 2001-05-14 | 2004-09-01 | 潘文成 | Liver cancer resisting medicine |
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| CN101904974A (en) * | 2010-07-28 | 2010-12-08 | 常熟雷允上制药有限公司 | Chinese medicinal composition for treating malignant tumor diseases and preparation method thereof |
| CN102357202A (en) * | 2011-10-17 | 2012-02-22 | 南京中医药大学 | Traditional Chinese medicine cancer toxin prescription for treating liver cancer and application thereof in pharmacy |
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