CN107281376A - A kind of snake gourd fruit pulp wets one's whistle composition and preparation method and application - Google Patents
A kind of snake gourd fruit pulp wets one's whistle composition and preparation method and application Download PDFInfo
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- CN107281376A CN107281376A CN201710545432.4A CN201710545432A CN107281376A CN 107281376 A CN107281376 A CN 107281376A CN 201710545432 A CN201710545432 A CN 201710545432A CN 107281376 A CN107281376 A CN 107281376A
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- China
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- parts
- extract
- fruit pulp
- snake gourd
- gourd fruit
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Classifications
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- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/364—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
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- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
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- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/48—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing plants or parts thereof, e.g. fruits, seeds, extracts
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/535—Perilla (beefsteak plant)
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/605—Morus (mulberry)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8967—Lilium, e.g. tiger lily or Easter lily
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
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- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Mycology (AREA)
- Inorganic Chemistry (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Molecular Biology (AREA)
- Nutrition Science (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Wet one's whistle composition and preparation method and application the invention discloses a kind of snake gourd fruit pulp, category medicines and health protection and food engineering field.Snake gourd fruit pulp wets one's whistle sugar composite by 35 50 parts of snake gourd fruit pulp syrup, and 40 50 parts of sucrose, 24 parts of perilla leaf extract, 23 parts of loquat-leaf extract, 12 parts of mulberry-leaf extract, 13 parts of ophiopogon japonicus extract, 24 parts of Bulbus Lilii extract is made.The present invention is to process the snake gourd fruit pulp accessory substance produced during Snakegourd Fruit seed and PERICARPIUM TRICHOSANTHIS as raw material, preparation snake gourd fruit pulp syrup is isolated and purified through modern crafts, and compound the Chinese medical extract with effects of clearing and nourishing throat, it is made with clearing heat and moistening lung, liyan jiedu, the pure natural composition of functions of loosening bowel relieving constipation, turning waste into wealth for discarded snake gourd fruit pulp resource can be achieved, not only low raw-material cost, and approach can be provided for innoxious effective disposal of snake gourd fruit pulp discarded object, also will be simultaneously that the sustainable development of Snakegourd Fruit medicine-food two-purpose resource industries and the industry chain building of recycling lay the foundation.
Description
Technical field
The present invention relates to a kind of regeneration method of medicinal and edible Chinese medicine production process accessory substance, and in particular to one
Kind of the snake gourd fruit pulp accessory substance discarded using producing during Snakegourd Fruit seed, PERICARPIUM TRICHOSANTHIS is raw material, prepares snake gourd fruit pulp and wets one's whistle composition
Method.
Background technology
Chinese juniper beach wormwood (Trichosanthes kirilowii Maxim.) climbs type herbaceous plant for Curcurbitaceae is perennial, its into
Ripe fruit, pericarp, seed are parts of generic medicinal plants, name Snakegourd Fruit, PERICARPIUM TRICHOSANTHIS, Chinese Drug Gualouzi.Wherein, Snakegourd Fruit has clearing away heat and eliminating phlegm, width
The work(of chest dissipating bind, moisturize laxation, swells for cough with lung heat, the thick turbid Huang of phlegm, chest impediment and cardialgia, accumulation of pathogens in chest feeling of fullness, acute mastitis, lung carbuncle, acute appendicitis
Bitterly, the disease such as constipation；The effect of PERICARPIUM TRICHOSANTHIS has clearing lung and eliminating phlegm, sharp gas relieving stuffiness of the chest by dispersing aggregation of pathogens, is usually used in cough with lung heat, chest side of body ruffian
Bitterly, the disease such as abscess of throat, newborn addiction acute mastitis；Chinese Drug Gualouzi has the effect of clearing lung and eliminating phlegm, laxation defaecation, is usually used in phlegm-heat cough, lung
The diseases such as empty cough caused by dryness, dry constipation of intestines, ulcerative carbuncle pyogenic infections.In addition, Snakegourd Fruit seed except make it is medicinal in addition to, it is also in recent years to be used as the edible heavily fortified point of leisure more
Really, and its market sales volume is huge.And during production PERICARPIUM TRICHOSANTHIS and Snakegourd Fruit seed, substantial amounts of snake gourd fruit pulp accessory substance is produced, because
Lack utilization ways and abandoned as discarded object, cause the wasting of resources and environmental pollution, and in the prior art not on melon
Document report of the beach wormwood flesh syrup for the relieving sore-throat that wets one's whistle.
Therefore, the regeneration and industrialization development of Snakegourd Fruit industrialization process accessory substance are carried out, realization is turned waste into wealth, not only
The sound development of Snakegourd Fruit resource industries can be promoted, the Green Development requirement that country advocates is also complied with, with important economy and society
Can benefit.
The content of the invention
It is profit prepared by raw material it is an object of the invention to provide a kind of utilization Snakegourd Fruit industrialization process accessory substance snake gourd fruit pulp
Larynx composition.Another object of the present invention is to provide preparation method and the application that the above wets one's whistle composition.
Technical scheme：In order to realize the above object the technical scheme that the present invention takes is：
A kind of snake gourd fruit pulp wets one's whistle composition, and it is made up of the raw material of following parts by weight：40-60 parts of snake gourd fruit pulp syrup, sugarcane
It is sugared 30-60 parts, 1-4 parts of perilla leaf extract, 2-4 parts of loquat-leaf extract, 1-3 parts of mulberry-leaf extract, ophiopogon japonicus extract 1-3
Part, 2-4 parts of Bulbus Lilii extract.
Preferably, above-described snake gourd fruit pulp wets one's whistle composition, and it is made up of the raw material of following parts by weight：Melon
45-55 parts of beach wormwood flesh syrup, 40-50 parts of sucrose, 1-2 parts of perilla leaf extract, 2-3 parts of loquat-leaf extract, mulberry-leaf extract 1-2
Part, 2-3 parts of ophiopogon japonicus extract, 3-4 parts of Bulbus Lilii extract.
As more preferably scheme, above-described snake gourd fruit pulp wets one's whistle composition, and it is made up of the raw material of following parts by weight：
50 parts of snake gourd fruit pulp syrup, 40 parts of sucrose, 1 part of perilla leaf extract, 3 parts of loquat-leaf extract, 1 part of mulberry-leaf extract, the tuber of dwarf lilyturf carries
Take 2 parts of thing, 3 parts of Bulbus Lilii extract.
Snake gourd fruit pulp syrup is to be prepared into using the snake gourd fruit pulp accessory substance produced using in PERICARPIUM TRICHOSANTHIS, Snakegourd Fruit seed production process as raw material
Arrive.
Also included in described raw material, 0.1-1 parts of 0.1-1 parts of flavoring essence and food coloring.
Above-mentioned raw materials are commercially available prod in addition to snake gourd fruit pulp syrup.
Snake gourd fruit pulp of the present invention wets one's whistle the preparation method of composition, comprises the following steps：
(1) processing PERICARPIUM TRICHOSANTHIS, remaining snake gourd fruit pulp after Snakegourd Fruit seed are taken, solubilizer is extracted, it is concentrated, isolate and purify and obtain melon
Beach wormwood flesh syrup；
(2) Snakegourd Fruit syrup obtained by step (1), sucrose and suitable are taken respectively by the parts by weight described in claim 1,2 or 3
Amount water is put into interlayer sugar cook conditioner, is heated with jacket steam, and steam pressure is 0.4-0.6MPa, and sugar cook temperature is 130-
150℃；
(3) after liquid glucose to be dissolved is in limpid, transparent syrup, sequentially added by the parts by weight described in claim 1,2 or 3
Perilla leaf extract, loquat-leaf extract, mulberry-leaf extract, ophiopogon japonicus extract, Bulbus Lilii extract, essence, pigment, it is uniform to reconcile
Stirring 20 minutes, obtains snake gourd fruit pulp and wets one's whistle composition.
Preferably, above-described snake gourd fruit pulp wets one's whistle the preparation method of composition, the extraction melon described in step (1)
Beach wormwood flesh syrup solvent for use is water or volumetric concentration 1%-80% ethanol.
Preferably, above-described snake gourd fruit pulp wets one's whistle the preparation method of composition, takes snake gourd fruit pulp, plus 5~10 times
The water of amount, ultrasonic extraction, after separation of solid and liquid, after extract solution is concentrated into right amount, through macroporous absorbent resin removal of impurities, water elution is dense
Contract to obtain snake gourd fruit pulp syrup；Detection and analysis is more than 80% containing sugared percentage composition.
Or processing PERICARPIUM TRICHOSANTHIS, remaining snake gourd fruit pulp after Snakegourd Fruit seed are taken, plus 6~20~60% ethanol of 12 times of amounts, heating
Refluxing extraction, after being separated through centrifugal solid-liquid, after extract solution is concentrated into right amount, through macroporous absorbent resin removal of impurities, water elution concentration
Obtain snake gourd fruit pulp syrup.Detection and analysis is more than 80% containing sugared percentage composition.
Preferably, above-described snake gourd fruit pulp wets one's whistle the preparation method of composition, the preparation of perilla leaf extract
Method is：Perilla leaf is taken, plus 8~12 times of 50%~90% alcohol refluxs of amount extract, and extract solution is concentrated under reduced pressure into dry, produces.
The preparation method of loquat-leaf extract is：Loguat leaf is taken, plus 8~12 times of amount 30%~50% alcohol refluxs extractions,
Extract solution is concentrated under reduced pressure into dry, produces.
The preparation method of mulberry-leaf extract is：Mulberry leaf are taken, plus 8~12 times of amount 0%~30% alcohol refluxs extractions, extract solution
It is concentrated under reduced pressure into dry, produces.
The preparation method of ophiopogon japonicus extract is：The tuber of dwarf lilyturf is taken, plus 8~12 times of amount 0%~30% alcohol refluxs extractions, extract solution
Equivalent crude drug 0.5g/mL is concentrated under reduced pressure into, plus ethanol stands 6~12 hours to alcohol content up to 60%~80%, separation of solid and liquid,
Supernatant is concentrated under reduced pressure into dry, produces.
The preparation method of Bulbus Lilii extract is：Lily is taken, plus 8~12 times of amount 0%~30% alcohol refluxs extractions, extract solution
Equivalent crude drug 0.5g/mL is concentrated under reduced pressure into, plus ethanol stands 6~12 hours to alcohol content up to 50%~60%, separation of solid and liquid,
Supernatant is concentrated under reduced pressure into dry, produces.
Show by lot of experiments, the snake gourd fruit pulp that provides of the present invention composition that wets one's whistle can be effectively improved throat discomfort
Symptom, there were significant differences compared with control group for total effective rate, can be applied to prepare the medicine with effects of clearing and nourishing throat or health care
Food.
The snake gourd fruit pulp that the present invention is provided wets one's whistle composition in the medicine or health food with effects of clearing and nourishing throat is prepared
Application, thoat-soothing drops, tablet, granule, syrup, mixture, soft extract is made in composition and pharmaceutically acceptable carrier
Or the medicine or health food of extract formulation.
The snake gourd fruit pulp that the present invention is provided wets one's whistle composition when thoat-soothing drops are made, and composition is heated and melted, and injects casting machine
Device, shaping drawing, packing machine carries out packaging and thoat-soothing drops is made after cooling.
The snake gourd fruit pulp that the present invention is provided wets one's whistle composition when tablet is made, and composition is crushed, with lactose or cornstarch
It is well mixed, it is necessary to when add magnesium stearate lubricant, tablet is made in then tabletting.
The snake gourd fruit pulp that the present invention is provided wets one's whistle composition when granule is made, and composition is crushed and lactose is well mixed,
Whole grain, dries, granule is made.
The snake gourd fruit pulp that the present invention is provided wets one's whistle composition when syrup is made, after composition heating fusing plus appropriate pure
Water is well mixed, filling, and syrup is made.
When other formulations are made in the vegetable oil composition that the present invention is provided, it can be prepared by pharmacy conventional method.
The present invention main component type, physics and chemistry according to contained by the discarded snake gourd fruit pulp resource produced in Snakegourd Fruit industrialization process
Matter etc., with reference to perilla leaf extract, loquat-leaf extract, mulberry-leaf extract, ophiopogon japonicus extract, Bulbus Lilii extract medicinal health
The indexs such as effect, physicochemical property, mouthfeel, by many experiments screen composition, gained wet one's whistle composition have it is in good taste, profit
The advantages of larynx health-care efficacy is clear and definite.Turning waste into wealth for snake gourd fruit pulp resource can be realized simultaneously, with important economic benefit and environment
Protect benefit.
Beneficial effect：The snake gourd fruit pulp accessory substance produced using in PERICARPIUM TRICHOSANTHIS, Snakegourd Fruit seed production process that the present invention is provided is original
Material, prepares snake gourd fruit pulp by continuous set technique and wets one's whistle composition, phase during medicinal and edible Chinese medicine Resource industrialization can be achieved
The effective disposal and regeneration of discarded object are closed, with higher economic and social benefit.And in raw material selection, according to tradition
Traditional Chinese medicine health-preserving, health care theory and modern pharmacological research achievement, are obtained by many experiments screening, with snake gourd fruit pulp syrup, perilla leaf
The medicinal and edible Chinese medicines such as extract, loquat-leaf extract, mulberry-leaf extract, ophiopogon japonicus extract, Bulbus Lilii extract are primary raw material
It is made.
Wherein, the polysaccharide containing weight/mass percentage composition more than 90%, oligosaccharide and monose, wherein grape in snake gourd fruit pulp syrup
Sugar, fructose content are up to 80%, and oligosaccharide sucrose and polyoses content improve immunity, relieving sore-throat profit up to 15% with good
Effect of larynx, and the part saponins isoreactivity composition still containing Snakegourd Fruit medicinal material, with clearing away heat and eliminating phlegm, relieving stuffiness of the chest by dispersing aggregation of pathogens, moisturize
The work(of laxation；Perilla leaf extract is to be prepared from from medicinal and edible Chinese medicine perilla leaf through modern crafts, with relieving exterior syndrome and dispelling cold,
The effect of relieving QI stagnancy in the stomach；Loquat-leaf extract is to be prepared from from medicinal and edible Chinese medicine loguat leaf through modern crafts, with clearing lung-heat
Cough-relieving, and stomach diuresis, the effect quenched the thirst；Mulberry-leaf extract is to be prepared from from medicinal and edible Chinese medicine mulberry leaf through modern crafts,
There is dispelling wind and heat from the body, clearing away the lungheat and moisturizing, clear liver and improve vision；Ophiopogon japonicus extract is through modern work from the medicinal and edible Chinese medicine tuber of dwarf lilyturf
Skill is prepared from, with quench one's thirst of promoting the production of body fluid, the effect moistened the lung and relieve the cough；Bulbus Lilii extract is through modern work from medicinal and edible Chinese medicine lily
Skill is prepared from, the effect with Yin nourishing and lung moistening, clearing away the heart fire and tranquillizing.There is natural traditional medicine-food two-purpose of multiple health care by more than
Plant resources is combined, and is intervened from multiple links, reach wet one's whistle, relieving sore-throat, clearing lung-heat, effect of defaecation.In addition, by from
Syrup, low production cost are prepared in snake gourd fruit pulp, and the introducing of other industrial chemicals can be avoided, is had no toxic side effect；Institute's medication food
Dual-purpose raw material can long-term credit, it is good in taste and without bad odor.
Embodiment
With reference to specific embodiment, the present invention is furture elucidated, it should be understood that these embodiments be merely to illustrate the present invention and
Limitation the scope of the present invention is not used in, after the present invention has been read, various of equal value shapes of the those skilled in the art to the present invention
The modification of formula falls within the application appended claims limited range.
A kind of snake gourd fruit pulp of embodiment 1 wets one's whistle the preparation method of composition, comprises the following steps：
(1) take and process remaining snake gourd fruit pulp after PERICARPIUM TRICHOSANTHIS, Snakegourd Fruit seed, plus 5 times of amount water, ultrasonic extraction, after separation of solid and liquid,
After extract solution is concentrated into right amount, through macroporous absorbent resin removal of impurities, water elution is concentrated to give snake gourd fruit pulp syrup, and (colorimetric determination is containing sugar
Amount is 85%)；
(2) snake gourd fruit pulp syrup 500g, sucrose 400g obtained by step (1) are taken, add water 100mL, input to interlayer, which is stirred off, to be reconciled
In machine, heated with jacket steam, steam pressure is 0.5MPa, sugar cook temperature is 140 DEG C；
(3) after liquid glucose to be dissolved is in limpid, transparent syrup, perilla leaf extract 10g, loquat-leaf extract are sequentially added
30g, mulberry-leaf extract 10g, ophiopogon japonicus extract 20g, Bulbus Lilii extract 30g, essence for organi juice 2g, beet red 2g, uniform reconcile are stirred
Mix 20 minutes；
(4) by the liquid glucose reconciled injection cast machine, shaping is pulled；
(5) packing machine carries out packaging and snake gourd fruit pulp thoat-soothing drops is made after cooling down.
A kind of snake gourd fruit pulp of embodiment 2 wets one's whistle the preparation method of composition, comprises the following steps：
(1) remaining snake gourd fruit pulp after processing PERICARPIUM TRICHOSANTHIS, Snakegourd Fruit seed, plus 6 times of 20% ethanol of amount, heating and refluxing extraction, warp are taken
After centrifugal solid-liquid separation, after extract solution is concentrated into right amount, through macroporous absorbent resin removal of impurities, water elution is concentrated to give snake gourd fruit pulp syrup
(colorimetric determination sugar content is 90%)；
(2) snake gourd fruit pulp syrup 500g, sucrose 450g obtained by step (1) are taken, add water 100mL, input to interlayer, which is stirred off, to be reconciled
In machine, heated with jacket steam, steam pressure is 0.45MPa, sugar cook temperature is 135 DEG C；
(3) after liquid glucose to be dissolved is in limpid, transparent syrup, perilla leaf extract 15g, loquat-leaf extract are sequentially added
20g, mulberry-leaf extract 15g, ophiopogon japonicus extract 25g, Bulbus Lilii extract 30g, milk flavour 3g, natural Beta-carotene 2g are even
With stirring 20 minutes；
(4) by the liquid glucose reconciled injection cast machine, shaping is pulled；
(5) packing machine carries out packaging and snake gourd fruit pulp thoat-soothing drops is made after cooling down.
A kind of snake gourd fruit pulp of embodiment 3 wets one's whistle the preparation method of composition, comprises the following steps：
(1) remaining snake gourd fruit pulp after processing PERICARPIUM TRICHOSANTHIS, Snakegourd Fruit seed, plus 8 times of 50% ethanol of amount, heating and refluxing extraction, warp are taken
Filter after separation of solid and liquid, after extract solution reclaims ethanol and is concentrated into right amount, through macroporous absorbent resin removal of impurities, water elution is concentrated to give
Snake gourd fruit pulp syrup (colorimetric determination sugar content is 90%)；
(2) snake gourd fruit pulp syrup 500g, sucrose 350g obtained by step (1) are taken, add water 100mL, input to interlayer, which is stirred off, to be reconciled
In machine, heated with jacket steam, steam pressure is 0.55MPa, sugar cook temperature is 145 DEG C；
(3) after liquid glucose to be dissolved is in limpid, transparent syrup, perilla leaf extract 25g, loquat-leaf extract are sequentially added
40g, mulberry-leaf extract 20g, ophiopogon japonicus extract 15g, Bulbus Lilii extract 20g, peach flavor 4g, gardenia blue 2g, it is uniform to reconcile
Stirring 20 minutes；
(4) by the liquid glucose reconciled injection cast machine, shaping is pulled；
(5) packing machine carries out packaging and snake gourd fruit pulp thoat-soothing drops is made after cooling down.
A kind of snake gourd fruit pulp of embodiment 4 wets one's whistle the preparation method of composition, comprises the following steps：
(1) remaining snake gourd fruit pulp after processing PERICARPIUM TRICHOSANTHIS, Snakegourd Fruit seed, plus 8 times of 50% ethanol of amount, heating and refluxing extraction, warp are taken
Filter after separation of solid and liquid, after extract solution reclaims ethanol and is concentrated into right amount, through macroporous absorbent resin removal of impurities, water elution is concentrated to give
Snake gourd fruit pulp syrup (colorimetric determination sugar content is 90%)；
(2) snake gourd fruit pulp syrup 500g, sucrose 350g obtained by step (1) are taken, add water 100mL, input to interlayer, which is stirred off, to be reconciled
In machine, heated with jacket steam, steam pressure is 0.55MPa, sugar cook temperature is 145 DEG C；
(3) after liquid glucose to be dissolved is in limpid, transparent syrup, perilla leaf extract 25g, loquat-leaf extract are sequentially added
40g, mulberry-leaf extract 20g, ophiopogon japonicus extract 15g, Bulbus Lilii extract 20g, peach flavor 4g, gardenia blue 2g, it is uniform to reconcile
Stirring 20 minutes；
(4) after the liquid glucose cooling reconciled, crush, be well mixed with lactose, add magnesium stearate lubricant, then press
Tablet is made in piece.
A kind of snake gourd fruit pulp of embodiment 5 wets one's whistle the preparation method of composition, comprises the following steps：
(1) remaining snake gourd fruit pulp after processing PERICARPIUM TRICHOSANTHIS, Snakegourd Fruit seed, plus 8 times of 50% ethanol of amount, heating and refluxing extraction, warp are taken
Filter after separation of solid and liquid, after extract solution reclaims ethanol and is concentrated into right amount, through macroporous absorbent resin removal of impurities, water elution is concentrated to give
Snake gourd fruit pulp syrup (colorimetric determination sugar content is 90%)；
(2) snake gourd fruit pulp syrup 500g, sucrose 350g obtained by step (1) are taken, add water 100mL, input to interlayer, which is stirred off, to be reconciled
In machine, heated with jacket steam, steam pressure is 0.55MPa, sugar cook temperature is 145 DEG C；
(3) after liquid glucose to be dissolved is in limpid, transparent syrup, perilla leaf extract 25g, loquat-leaf extract are sequentially added
40g, mulberry-leaf extract 20g, ophiopogon japonicus extract 15g, Bulbus Lilii extract 20g, peach flavor 4g, gardenia blue 2g, it is uniform to reconcile
Stirring 20 minutes；
(4) after the liquid glucose reconciled is cooled down, crush, be well mixed with lactose, whole grain, dry, granule is made.
A kind of snake gourd fruit pulp of embodiment 6 wets one's whistle the preparation method of composition, comprises the following steps：
(1) remaining snake gourd fruit pulp after processing PERICARPIUM TRICHOSANTHIS, Snakegourd Fruit seed, plus 8 times of 50% ethanol of amount, heating and refluxing extraction, warp are taken
Filter after separation of solid and liquid, after extract solution reclaims ethanol and is concentrated into right amount, through macroporous absorbent resin removal of impurities, water elution is concentrated to give
Snake gourd fruit pulp syrup (colorimetric determination sugar content is 90%)；
(2) snake gourd fruit pulp syrup 500g, sucrose 350g obtained by step (1) are taken, add water 100mL, input to interlayer, which is stirred off, to be reconciled
In machine, heated with jacket steam, steam pressure is 0.55MPa, sugar cook temperature is 145 DEG C；
(3) after liquid glucose to be dissolved is in limpid, transparent syrup, perilla leaf extract 25g, loquat-leaf extract are sequentially added
40g, mulberry-leaf extract 20g, ophiopogon japonicus extract 15g, Bulbus Lilii extract 20g, peach flavor 4g, gardenia blue 2g, it is uniform to reconcile
Stirring 20 minutes；
(4) it is filling after the liquid glucose reconciled heating fusing appropriate amount of purified water will be added to be well mixed, syrup is made.
Embodiment 7 wet one's whistle relieving sore-throat experiment
Clinical treatment research has been carried out to throat discomfort patient, the validity of this product is determined.
1st, case selection：Sphagitis is suffered from observation 32, and there is the throat discomfort patient of peculiar smell in oral cavity, and randomized double-blind is divided into two
Group：Test group 12, male 8, women 4, average age 36.8 years old；Control group 1 totally 10, male 6, women 4 is put down
Equal 36.9 years old age；Control group 2 totally 10, male 5, women 5, average age 36.6 years old.
2nd, treatment method：
Test group：Take and wet one's whistle sugar composite, daily six times, every time one using the made snake gourd fruit pulp of example 3.
Control group 1：The thoat-soothing drops technique taken such as example 3, the sucrose that snake gourd fruit pulp syrup is replaced with into equivalent (is free of Snakegourd Fruit
Flesh syrup), profile, taste are similar to test group, and dose is identical with test group.
Control group 2：The thoat-soothing drops technique taken such as embodiment 3, perilla leaf extract, loquat-leaf extract, mulberry leaf are extracted
Thing, ophiopogon japonicus extract and Bulbus Lilii extract replace with the sucrose (being free of Chinese medical extract) of equivalent, profile, taste and test group phase
Seemingly, dose is identical with test group.
Evaluation criteria：
It is effective：Take symptom after 7 days to have clear improvement, symptom disappears substantially after 2 weeks.
Effectively：Take symptom after 7 days to make moderate progress, most of symptom mitigation or disappearance after 2 weeks.
It is invalid：Rear symptom is taken without significant change or improvement.
3rd, result：As shown in table 1：
The test group of table 1 and control group evaluation result
Compared * P with control group<0.01；
More than test result indicates that, tested crowd is taking the snake gourd fruit pulp thoat-soothing drops combination of compositions that provides of the present invention
There is not significant discomfort symptom during thing, and throat discomfort symptom can be effectively improved, total effective rate has significantly compared with control group
Difference, as a result shows that the snake gourd fruit pulp thoat-soothing drops combination of compositions thing that the present invention is provided has effects that significantly to alleviate throat discomfort.
Described above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, under the premise without departing from the principles of the invention, some improvements and modifications can also be made, these improvements and modifications also should
It is considered as protection scope of the present invention.
Claims (10)
- The composition 1. a kind of snake gourd fruit pulp wets one's whistle, it is characterised in that it is made up of the raw material of following parts by weight：Snake gourd fruit pulp syrup 40-60 parts, 30-60 parts of sucrose, 1-4 parts of perilla leaf extract, 2-4 parts of loquat-leaf extract, 1-3 parts of mulberry-leaf extract, the tuber of dwarf lilyturf 1-3 parts of extract, 2-4 parts of Bulbus Lilii extract.
- The composition 2. snake gourd fruit pulp according to claim 1 wets one's whistle, it is characterised in that it by following parts by weight raw material system Into：45-55 parts of snake gourd fruit pulp syrup, 40-50 parts of sucrose, 1-2 parts of perilla leaf extract, 2-3 parts of loquat-leaf extract, mulberry leaf are extracted 1-2 parts of thing, 2-3 parts of ophiopogon japonicus extract, 3-4 parts of Bulbus Lilii extract.
- The composition 3. snake gourd fruit pulp according to claim 2 wets one's whistle, it is characterised in that it by following parts by weight raw material system Into：50 parts of snake gourd fruit pulp syrup, 40 parts of sucrose, 1 part of perilla leaf extract, 3 parts of loquat-leaf extract, 1 part of mulberry-leaf extract, the tuber of dwarf lilyturf 2 parts of extract, 3 parts of Bulbus Lilii extract.
- The preparation method of composition 4. the snake gourd fruit pulp described in any one of claims 1 to 3 wets one's whistle, it is characterised in that including following Step：(1) snake gourd fruit pulp is taken, solubilizer is extracted, it is concentrated, isolate and purify and obtain snake gourd fruit pulp syrup；(2) Snakegourd Fruit syrup, sucrose obtained by step (1) is taken to put into folder respectively by the parts by weight described in claim 1,2 or 3 In layer sugar cook conditioner, heated with jacket steam, steam pressure is 0.4-0.6MPa, sugar cook temperature is 130-150 DEG C；(3) after liquid glucose to be dissolved is in limpid, transparent syrup, purple perilla is sequentially added by the parts by weight described in claim 1,2 or 3 Leaf extract, loquat-leaf extract, mulberry-leaf extract, ophiopogon japonicus extract, Bulbus Lilii extract, essence, pigment, uniform reconcile are stirred Mix, obtain snake gourd fruit pulp and wet one's whistle composition.
- The preparation method of composition 5. snake gourd fruit pulp according to claim 4 wets one's whistle, it is characterised in that described in step (1) It is water or volumetric concentration 1%-80% ethanol to extract snake gourd fruit pulp syrup solvent for use.
- The preparation method of composition 6. snake gourd fruit pulp according to claim 4 wets one's whistle, it is characterised in thatTake snake gourd fruit pulp, plus 5~water of 10 times of amounts, ultrasonic extraction, after separation of solid and liquid, extract solution be concentrated into it is appropriate after, through macropore Polymeric adsorbent removal of impurities, water elution is concentrated to give snake gourd fruit pulp syrup；Or processing PERICARPIUM TRICHOSANTHIS, remaining snake gourd fruit pulp after Snakegourd Fruit seed are taken, plus 6~20~60% ethanol of 12 times of amounts, be heated to reflux Extract, after being separated through centrifugal solid-liquid, after extract solution is concentrated into right amount, through macroporous absorbent resin removal of impurities, water elution is concentrated to give melon Beach wormwood flesh syrup.
- The preparation method of composition 7. snake gourd fruit pulp according to claim 4 wets one's whistle, it is characterised in thatThe preparation method of perilla leaf extract is：Perilla leaf is taken, plus 8~12 times of amount 50%~90% alcohol refluxs extractions, extracts Liquid is concentrated under reduced pressure into dry, produces.The preparation method of loquat-leaf extract is：Loguat leaf is taken, plus 8~12 times of amount 30%~50% alcohol refluxs extractions, extracts Liquid is concentrated under reduced pressure into dry, produces.The preparation method of mulberry-leaf extract is：Mulberry leaf are taken, plus 8~12 times of amount 0%~30% alcohol refluxs extractions, extract solution decompression It is concentrated to dryness, produces.The preparation method of ophiopogon japonicus extract is：The tuber of dwarf lilyturf is taken, plus 8~12 times of amount 0%~30% alcohol refluxs extractions, extract solution decompression Equivalent crude drug 0.5g/mL is concentrated into, plus ethanol stands 6~12 hours, separation of solid and liquid, supernatant to alcohol content up to 60%~80% Liquid is concentrated under reduced pressure into dry, produces.The preparation method of Bulbus Lilii extract is：Lily is taken, plus 8~12 times of amount 0%~30% alcohol refluxs extractions, extract solution decompression Equivalent crude drug 0.5g/mL is concentrated into, plus ethanol stands 6~12 hours, separation of solid and liquid, supernatant to alcohol content up to 50%~60% Liquid is concentrated under reduced pressure into dry, produces.
- The composition 8. snake gourd fruit pulp according to claims 1 to 3 wets one's whistle, can add 0.1-1 parts of flavoring essence and food if necessary With 0.1-1 parts of pigment.
- 9. the snake gourd fruit pulp described in claims 1 to 3 wets one's whistle, composition is preparing medicine or health care food with effects of clearing and nourishing throat Application in product.
- 10. snake gourd fruit pulp according to claim 9 wets one's whistle, composition is preparing medicine or health care with effects of clearing and nourishing throat Application in food, it is characterised in that thoat-soothing drops, tablet, granule, sugar is made in composition and pharmaceutically acceptable carrier Starch the medicine or health food of agent, mixture, soft extract or extract formulation.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102125235A (en) * | 2010-12-30 | 2011-07-20 | 陈慧婷 | Prescription of pear syrup for moistening dryness and nourishing lung and preparation method thereof |
| CN103768534A (en) * | 2014-02-17 | 2014-05-07 | 南京中医药大学 | Traditional Chinese medicinal composition with anti-tumor activity |
-
2017
- 2017-07-06 CN CN201710545432.4A patent/CN107281376A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102125235A (en) * | 2010-12-30 | 2011-07-20 | 陈慧婷 | Prescription of pear syrup for moistening dryness and nourishing lung and preparation method thereof |
| CN103768534A (en) * | 2014-02-17 | 2014-05-07 | 南京中医药大学 | Traditional Chinese medicinal composition with anti-tumor activity |
Non-Patent Citations (4)
| Title |
|---|
| TANGPANJIANWEI: "栝楼", 《新浪博客》 * |
| 畅洪昇: "《药食合一使用手册》", 31 May 2014, 中国纺织出版社 * |
| 编写组: "《补身秘笈---夏季实用保健汤菜谱》", 31 December 2003, 广州出版社 * |
| 魏金凤: "加减清燥救肺汤治疗喉痒咳嗽220 例的临床观察", 《四川中医》 * |
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