CN110193050A - Traditional Chinese medicine composition for preventing recurrence and metastasis of digestive tract tumor and preparation method thereof - Google Patents
Traditional Chinese medicine composition for preventing recurrence and metastasis of digestive tract tumor and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for preventing recurrence and metastasis of digestive tract tumors and a preparation method thereof, belonging to the technical field of traditional Chinese medicines and being prepared from the following raw materials in parts by weight: 5-13 parts of barbed skullcap herb, 10-15 parts of dandelion, 3-10 parts of white mustard seed, 8-15 parts of poria cocos, 9-15 parts of rhizoma arisaematis, 5-10 parts of lucid ganoderma, 10-15 parts of common andrographis herb, 3-9 parts of pinellia ternate, 6-10 parts of ginseng, 10-14 parts of astragalus membranaceus, 0.5-2 parts of spreading hedyotis herb and 1.5-7 parts of liquorice; the invention starts from the pathogenesis of the digestive tract tumor, adopts raw materials with different drug properties, has scientific and reasonable compatibility, and can condition the dynamic balance of the organism, improve the immunity of the organism, effectively recover the normal physiological function of the digestive tract and achieve the aim of preventing the recurrence and the metastasis of the digestive tract tumor by combining the raw materials.
Description
Technical field
The invention belongs to technical field of Chinese medicine, and in particular to a kind of Chinese medicine group for preventing tumor in digestive tract recurrence and transfer
Close object and preparation method.
Background technique
In recent years, the disease incidence of tumour improves year by year, and tumor in digestive tract accounts for larger specific gravity in tumor invasion, alimentary canal
Tumour covering scope is wide, including gastric cancer, the cancer of the esophagus, intestinal cancer etc..Tumor in digestive tract is not easy to be found, and easily transfer, therefore patient
It has been often middle and advanced stage when medical treatment.
The method of digestive tract tumor treatment is operative treatment at present, but this method can not eradicate tumour completely, and
Later period needs to carry out chemotherapy, while bringing great pain to patient, reduces the immunity of patient, and still have alimentary canal
The risk of metastases, the easy to recur and transfer of tumor in digestive tract are the main reason for causing operative treatment easily to fail.
Motherland's medicine thinks that the reason of tumor recurrence transfer is the influence due to internal microenvironment, so that organism balance loses
It adjusts, the ability of inhibiting tumor cell is declined, to cause the pent-up of gas, blood, phlegm, food.Internal cause and external cause can be divided into, internal cause is mainly
The inside microenvironment of body, external cause refers to since body function reduces, and is easy the invasion by external cult poison, leads oncogenic hair
It is raw, i.e., " heresy is gathered, gas must void ".There are the Chinese medicines of a variety for the treatment of tumor in digestive tract in currently available technology, such as apply
Number be 201611224318.3, the patent of entitled " a kind of Chinese medicine for treating tumor in digestive tract " specifically discloses in this
Medicine composition is 3-12 grams of dendrobium nobile, 3-15 grams of tortoise plastron, 5-15 grams of Semen Cuscutae, 4-16 grams of Radix Codonopsis, 5-15 grams of wilsonii, panax japonicus majoris 3-12
Gram, 4-10 grams of asparagus fern, 6-12 grams of Radix Ophiopogonis, 2-9 grams of radix polygonati officinalis, 3-9 grams of turmeric, 4-12 grams of false-yellowflower milkwort root or herb, 4-10 grams of Common Camptotheca Fruit, cowherb
6-12 grams of art, 3-9 grams of motherwort, 3-8 grams of Radix Salviae Miltiorrhizae, 4-10 grams of Rabdosia rubescens；But the above-mentioned traditional Chinese medicine ingredients of analysis, it can not meet
The raw physiological property of tumor in digestive tract morbidity, causes therapeutic effect that can not reach expection.Therefore, researching and developing one kind, to meet alimentary canal swollen
The Chinese medicine of tumor morbidity pathology, is of great significance for the recurrence of prevention tumor in digestive tract and transfer.
Summary of the invention
The present invention provides a kind of Chinese medicine compositions and preparation method for preventing tumor in digestive tract recurrence and transfer, solve
Above-mentioned technical problem.
First purpose of the invention is to provide a kind of Chinese medicine composition for preventing tumor in digestive tract recurrence and transfer, by following
The raw material of parts by weight is made: 5~13 parts of Sculellaria barbata, 10~15 parts of dandelion, 3~10 parts of semen brassicae, Poria cocos 8~15 part, day
It is 9~15 parts of Southern Star, 5~10 parts of ganoderma lucidum, 10~15 parts of Herba Andrographitis, 3~9 parts of the tuber of pinellia, 6~10 parts of ginseng, 10~14 parts of Radix Astragali, white
Flower 0.5~2 part of HERBA HEDYOTIS DIFFUSAE, 1.5~7 parts of Radix Glycyrrhizae.
Preferably, the Chinese medicine composition is made by the raw material of following parts by weight: 8 parts of Sculellaria barbata, 12 parts of dandelion, white
6 parts of mustard seed, 9 parts of Poria cocos, 10 parts of rhizoma arisaematis, 8 parts of ganoderma lucidum, 13 parts of Herba Andrographitis, 5 parts of the tuber of pinellia, 8 parts of ginseng, 12 parts of Radix Astragali, agkistrodon
1 part, 5 parts of Radix Glycyrrhizae of tongue grass.
Second purpose of the invention is to provide the preparation of the Chinese medicine composition of above-mentioned prevention tumor in digestive tract recurrence and transfer
Method, specifically includes the following steps:
S1: the raw material of following parts by weight is weighed respectively: 5~13 parts of Sculellaria barbata, 10~15 parts of dandelion, semen brassicae 3~
10 parts, 8~15 parts of Poria cocos, 9~15 parts of rhizoma arisaematis, 5~10 parts of ganoderma lucidum, 10~15 parts of Herba Andrographitis, 3~9 parts of the tuber of pinellia, ginseng 6~
10 parts, 10~14 parts of Radix Astragali, 0.5~2 part of oldenlandia diffusa, 1.5~7 parts of Radix Glycyrrhizae；
S2: ganoderma lucidum in S1 and ginseng are crushed respectively, are sieved, and hybrid particles are made in mixing；Add in the hybrid particles
Enter ethyl alcohol preparation alcohol extracting cream；
S3: by Sculellaria barbata, dandelion, semen brassicae, Poria cocos, rhizoma arisaematis, Herba Andrographitis, the tuber of pinellia, Radix Astragali, oldenlandia in S1
Grass, Radix Glycyrrhizae mixing, obtain mixed raw material；In mixed raw material plus water prepares water and mentions cream；
S4: the water of the alcohol extracting cream of S2 preparation and S3 preparation is mentioned into cream and is uniformly mixed, the Chinese medicine composition is made.
Preferably, in the S2 alcohol extracting cream specific preparation step are as follows:
Ganoderma lucidum in S1 and ginseng are crushed respectively, are sieved, hybrid particles are made in mixing；It is added in the hybrid particles
The ethyl alcohol that mass fraction is 90% is impregnated, and 15~20h of dip time obtains leaching liquor；Leaching liquor is concentrated into 65~75 DEG C
When relative density be 1.2~1.25 alcohol extracting cream；The ethanol consumption is 1~2 times of the hybrid particles quality.
Preferably, water proposes the specific preparation step of cream in the S3 are as follows:
By Sculellaria barbata in S1, dandelion, semen brassicae, Poria cocos, rhizoma arisaematis, Herba Andrographitis, the tuber of pinellia, Radix Astragali, oldenlandia diffusa, sweet
Grass mixing, obtains mixed raw material；The water of 5~8 times of the mixed raw material quality is added for the first time, decocts 4~6h, obtain the first filtrate and
First filter residue；It takes the first filter residue that 3~5 times of water of mixed raw material quality are added, decocts 3~4h；Obtain the second filtrate and the second filter residue；
It takes the second filter residue that 1~2 times of water of mixed raw material quality is added, decocts 0.5~2h, obtain third filtrate；Merge the first filtrate, second
Filtrate and third filtrate, the water that relative density is 1.15~1.25 when being concentrated into 65 DEG C mention cream.
Preferably, the pharmaceutical dosage form of the Chinese medicine composition is capsule, granule, tablet or pill.
Each raw material effect that the present invention uses is as follows:
Sculellaria barbata, perennial vertical herbage, acrid flavour, hardship are cold in nature；Distributed in lung channel, Liver Channel, kidney channel；Clearing heat and detoxicating, promoting blood circulationization
The stasis of blood, diuresis；Anticancer improves function of immune system, but large bolus injection can inhibit mouse thymus index；There is bacteriostasis；Have compared with
Strong confrontation smooth muscle shrinks function as caused by histamine；There are good spasmolysis phlegm-dispelling functions.With diuresis, excited breathing and solution
The effect of snake venom.
Dandelion, composite family Dandelion herbaceos perennial, sweet, slight bitter are trembled with fear；Return liver, stomach meridian；It is clear clearing heat and detoxicating, disappear
Swollen dissipating bind, inducing diuresis for treating strangurtia.For furuncle swelling toxin, acute mastitis, scrofula, hot eyes, pharyngalgia, pulmonary abscess, acute appendicitis, jaundice with damp-heat pathogen, puckery pain of heat gonorrhea.
Semen brassicae, it is acrid in flavour and warm in nature；Enter lung, stomach meridian；Promoting circulation of qi and eliminating phlegm is cured mainly, warming spleen and stomach for dispelling cold is removed obstruction in channels to relieve pain；Control phlegm retention cough and asthma, chest side of body
Turgor pain, gastric disorder causing nausea vomiting, aphasia from apoplexy, limbs numbness pain is numb, tinea pedis, negative subcutaneous ulcer, pyogenic infections, treating swelling and pain by traumatic injury；" Elementary Medicine ": "
Sharp chest diaphragm phlegm, only regurgitation spits food, and phlegm is coughed upper gas, and aphasia from apoplexy, appearance color is yellow, five viscera settling, only more urinating at night.It controls again and flutters the damage stasis of blood
Blood."
Poria cocos, it is sweet, light, it puts down；Return heart, lung, spleen, kidney channel；Clearing damp and promoting diuresis, invigorating the spleen calming heart；For edema and little urine, phlegm retention is dizzy
Throb with fear, spleen eating less, loose stool diarrhea, confused and worried, insomnia of palpitating with fear；" Bie Lu ": it " only quenches one's thirst, likes to sleep, big abdomen, leaching drips, phlegm in diaphragm
Water, oedema leaching knot.It opens chest internal organs, adjusts visceral-qi, cut down kidney heresy, long yin, benefiting energy is protected during mind keeps."
Rhizoma arisaematis, bitter, pungent, gas is flat, and can rise can drop, and Yin Zhongyang is toxic；Enter spleen, lung, the heart three to pass through.Kind energy resolving sputum, benefit
Hard product is broken in gas under diaphragm, scattered blood stasis, fetal abortion, and subduing inflammation controls aphasia from apoplexy, and pole can switch, simultaneous to control tetanus；Pass is cut again forces the way to it
Will, can one use, without reusable；The three lives drinks it, help monkshood with unusual, eliminating the phlegm and change it is stagnant, it is non-borrow its clearing lung-heat and feel at ease, therefore
Only temporary ear.Although in Sanshengyin Decoction, if being monarch without ginseng, monkshood, Southern Star are all useless.That is a Sanshengyin Decoction can realize use
Medicine it is wonderful.
Ganoderma lucidum, it is sweet in flavor, it is warm-natured, enter the heart, spleen, kidney, lung four and passes through；Though the taste of ganoderma lucidum is sweet, also micro-strip point is bitter, but it is bitter and
It is fragrant.With anti-cancer and cancer-preventing, liver detoxification, hypoglycemic, anti-angiocardiopathy, anti-hyperlipidemia, apoplexy, anti-aging and improves nerve and decline
The effects of weak；Immunity can be improved, enhance the anti-cancer ability of patient itself, there is the effect of anti-cancer and cancer-preventing.
Herba Andrographitis, it is bitter, it trembles with fear；Return heart, lung, large intestine, bladder meridian.It is clearing heat and detoxicating, eliminating dampness；With stronger clearing heat and detoxicating, resist
The effect of infection can be widely used for respiratory tract, alimentary canal, urinary system and the multi-infections diseases such as skin is suppurative.
The tuber of pinellia, it is acrid in flavour and warm in nature, it is toxic；Enter spleen, stomach meridian.It is eliminating dampness and eliminating phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass；Wet phlegm and cold drink is controlled, is vomitted,
Gastric disorder causing nausea, cough and phlegm, fullness in chest, phlegm and headache, dizziness and sleepless, outer subduing inflammation.
Ginseng, sweet, slight bitter are put down；Returns spleen, lung, the heart channel of Hang-Shaoyin.Replenish vital energy, restore pulse, and strengthen and remove vital energy reinforces the spleen to benefit the lung, and promotes the production of body fluid, and calms the nerves；With
It to be taken off in physically weak, cold weak pulse of limb, spleen eating less, the deficiency syndrome of the lung is breathed with cough, injury thirst, Heat Diabetes, and prolonged illness void is thin, insomnia of palpitating with fear, sun
Impotence palace cold；Heart failure, cardiogenic shock.
Radix Astragali, sweet, tepor；Return lung, spleen, liver and kidney channel.Radix Astragali has invigorating qi for consolidating superficies, arrest sweating admittedly take off, torr sore myogenic, Li Shui to disappear
The effect of swollen；For treating deficiency of vital energy and acking in strength, the sinking of qi of middle-jiao, rush down prolapse of the anus for a long time, uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, ulcer is difficult to burst bursts not long
It holds back, blood deficiency chlorosis, Heat Diabetes, chronic nephritis, albuminuria, diabetes etc.；Astragalus root invigorating middle warmer and replenishing QI, raw solid table torr sore.
Oldenlandia diffusa, it is sweet, light, it is cool；Enter stomach, large intestine, small intestinl channel；It is clearing heat and detoxicating, inducing diuresis to remove edema, promoting blood circulation and stopping pain；For
Acute appendicitis (ecphyaditis), sore furuncle poison, jaundice with damp-heat pathogen, the diseases such as difficult urination；Boil carbuncle swells, venomous snake bite are controlled in external application.
Radix Glycyrrhizae, sweet and neutral；Return heart, lung, spleen, stomach meridian；It invigorates the spleen and benefits qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain reconciles all
Medicine；For weakness of the spleen and the stomach, fatigue and weakness, shortness of breath and palpitation, coughing with a lot of sputum, stomach duct and abdomen, four limbs contraction, carbuncle sore tumefacting virus, abirritant
It is object toxicity, strong.
Compared with prior art, the present invention has the following advantages:
" Jing Yue's complete work●Blood " cloud: " blood must be by gas, gas row then blood, therefore all blood to be controlled, then or attacks or mend, all when with regulating the qi flowing in the channels
For elder generation "；The present invention based on " logical drop ", and is equipped with righting drug, so as to effectively restore from ascending or descending movement of vital Qi theory
Gastral fundamental characteristics fundamentally improves organismic internal environment, the recurrence and transfer of pre- preventing tumor.Based on above-mentioned theory, originally
Invention is using ginseng, ganoderma lucidum, Radix Astragali and Poria cocos as monarch drug in a prescription, and four medicines share the function for playing qi and activate blood circulation removing toxic substances, treating both manifestation and root cause of disease, ginseng,
Ganoderma lucidum, Radix Astragali and Poria cocos QI invigorating, restore the hinge of Central Region lifting with tonifying spleen void；Sculellaria barbata, dandelion, oldenlandia diffusa and punching
Lotus is ministerial drug, clearing heat and detoxicating, dispels internal cult poison, and auxiliary monarch drug in a prescription righting healthy tendency eliminating evil is outgoing；Semen brassicae, rhizoma arisaematis and the tuber of pinellia are
Adjutant, eliminating dampness and eliminating phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass improve body phlegm, silt microenvironment, and further righting healthy tendency enters body；It is sweet
Grass neutralizes above-mentioned all medicines to make medicine.The present invention is from tumor in digestive tract pathogenesis, using the raw material of different properties, compatibility
Scientific and reasonable, above-mentioned all medicines share is capable of the dynamic equilibrium of conditioning engine body, improves immunity of organisms, effectively restores alimentary canal
Normal physiological function, achieve the purpose that prevent tumor in digestive tract relapse and metastasis.
Specific embodiment
In order to enable those skilled in the art to more fully understand, technical solution of the present invention is practiced, below with reference to specific
The invention will be further described for embodiment and data, but illustrated embodiment is not as a limitation of the invention.
Embodiment 1
A kind of Chinese medicine composition preventing tumor in digestive tract recurrence and transfer, is made: half by the raw material of following parts by weight
Branch lotus 5g, dandelion 10g, semen brassicae 3g, Poria cocos 8g, rhizoma arisaematis 9g, ganoderma lucidum 5g, Herba Andrographitis 10g, tuber of pinellia 3g, ginseng 6g, Radix Astragali
10g, oldenlandia diffusa 0.5g, Radix Glycyrrhizae 1.5g；
Above-mentioned Chinese medicine composition is specifically made by following steps:
S1: the raw material of following parts by weight: Sculellaria barbata 5g, dandelion 10g, semen brassicae 3g, Poria cocos 8g, Tian Nan is weighed respectively
Star 9g, ganoderma lucidum 5g, Herba Andrographitis 10g, tuber of pinellia 3g, ginseng 6g, Radix Astragali 10g, oldenlandia diffusa 0.5g, Radix Glycyrrhizae 1.5g；
S2: ganoderma lucidum in S1 and ginseng are crushed respectively, are sieved, and hybrid particles are made in mixing；Add in the hybrid particles
Enter the ethyl alcohol that mass fraction is 90% to be impregnated, room temperature immersion 15h obtains leaching liquor；It is opposite when leaching liquor is concentrated into 65 DEG C
The alcohol extracting cream that density is 1.2；The ethanol consumption is 1 times of the granular mass；
S3: by Sculellaria barbata, dandelion, semen brassicae, Poria cocos, rhizoma arisaematis, Herba Andrographitis, the tuber of pinellia, Radix Astragali, oldenlandia in S1
Grass, Radix Glycyrrhizae mixing, obtain mixed raw material；The water of 5 times of the mixed raw material quality is added for the first time, decocts 4h, obtain the first filtrate and
First filter residue；It takes the first filter residue that 3 times of water of mixed raw material quality are added, decocts 3h；Obtain the second filtrate and the second filter residue；Take second
1 times of water of mixed raw material quality is added in filter residue, decocts 0.5h, obtains third filtrate；Merge the first filtrate, the second filtrate and third filter
Liquid, the water that relative density is 1.15 when being concentrated into 65 DEG C mention cream；
S4: the water of the alcohol extracting cream of S2 preparation and S3 preparation is mentioned into cream and is uniformly mixed, the Chinese medicine composition is made, and prepare
At capsule.
Embodiment 2
A kind of Chinese medicine composition preventing tumor in digestive tract recurrence and transfer, is made: half by the raw material of following parts by weight
Branch lotus 7g, dandelion 12g, semen brassicae 5g, Poria cocos 10g, rhizoma arisaematis 12g, ganoderma lucidum 7g, Herba Andrographitis 12g, tuber of pinellia 4g, ginseng 7g, Huang
Stilbene 12g, oldenlandia diffusa 1g, Radix Glycyrrhizae 6g；
Above-mentioned Chinese medicine composition is specifically made by following steps:
S1: the raw material of following parts by weight is weighed respectively: a kind of Chinese traditional medicine composition for preventing tumor in digestive tract recurrence and transfer
Object is made by the raw material of following parts by weight: Sculellaria barbata 7g, dandelion 12g, semen brassicae 5g, Poria cocos 10g, rhizoma arisaematis 12g, spirit
Sesame 7g, Herba Andrographitis 12g, tuber of pinellia 4g, ginseng 7g, Radix Astragali 12g, oldenlandia diffusa 1g, Radix Glycyrrhizae 6g；
S2: ganoderma lucidum in S1 and ginseng are crushed respectively, are sieved, and hybrid particles are made in mixing；Add in the hybrid particles
Enter the ethyl alcohol that mass fraction is 90% to be impregnated, room temperature immersion 17h obtains leaching liquor；It is opposite when leaching liquor is concentrated into 70 DEG C
The alcohol extracting cream that density is 1.23；The ethanol consumption is 1.5 times of the granular mass；
S3: by Sculellaria barbata, dandelion, semen brassicae, Poria cocos, rhizoma arisaematis, Herba Andrographitis, the tuber of pinellia, Radix Astragali, oldenlandia in S1
Grass, Radix Glycyrrhizae mixing, obtain mixed raw material；The water of 6 times of the mixed raw material quality is added for the first time, decocts 5h, obtain the first filtrate and
First filter residue；It takes the first filter residue that 4 times of water of mixed raw material quality are added, decocts 3.5h；Obtain the second filtrate and the second filter residue；Take
1.5 times of water of mixed raw material quality are added in two filter residues, decoct 1h, obtain third filtrate；Merge the first filtrate, the second filtrate and third
Filtrate, the water that relative density is 1.2 when being concentrated into 65 DEG C mention cream；
S4: the water of the alcohol extracting cream of S2 preparation and S3 preparation is mentioned into cream and is uniformly mixed, the Chinese medicine composition is made, and prepare
At capsule.
Embodiment 3
A kind of Chinese medicine composition preventing tumor in digestive tract recurrence and transfer, is made: half by the raw material of following parts by weight
Branch lotus 8g, dandelion 12g, semen brassicae 6g, Poria cocos 9g, rhizoma arisaematis 10g, ganoderma lucidum 8g, Herba Andrographitis 13g, tuber of pinellia 5g, ginseng 8g, Huang
Stilbene 12g, oldenlandia diffusa 1g, Radix Glycyrrhizae 5g；
Above-mentioned Chinese medicine composition is specifically made by following steps:
S1: the raw material of following parts by weight is weighed respectively: a kind of Chinese traditional medicine composition for preventing tumor in digestive tract recurrence and transfer
Object is made by the raw material of following parts by weight: Sculellaria barbata 8g, dandelion 12g, semen brassicae 6g, Poria cocos 9g, rhizoma arisaematis 10g, ganoderma lucidum
8g, Herba Andrographitis 13g, tuber of pinellia 5g, ginseng 8g, Radix Astragali 12g, oldenlandia diffusa 1g, Radix Glycyrrhizae 5g；
S2: ganoderma lucidum in S1 and ginseng are crushed respectively, are sieved, and hybrid particles are made in mixing；Add in the hybrid particles
Enter the ethyl alcohol that mass fraction is 90% to be impregnated, dip time 18h obtains leaching liquor；It is opposite when leaching liquor is concentrated into 75 DEG C
The alcohol extracting cream that density is 1.25；The ethanol consumption is 1.5 times of the granular mass；
S3: by Sculellaria barbata, dandelion, semen brassicae, Poria cocos, rhizoma arisaematis, Herba Andrographitis, the tuber of pinellia, Radix Astragali, oldenlandia in S1
Grass, Radix Glycyrrhizae mixing, obtain mixed raw material；The water of 7 times of the mixed raw material quality is added for the first time, decocts 5h, obtain the first filtrate and
First filter residue；It takes the first filter residue that 4 times of water of mixed raw material quality are added, decocts 2.5h；Obtain the second filtrate and the second filter residue；Take
1.5 times of water of mixed raw material quality are added in two filter residues, decoct 1h, obtain third filtrate；Merge the first filtrate, the second filtrate and third
Filtrate, the water that relative density is 1.25 when being concentrated into 65 DEG C mention cream；
S4: the water of the alcohol extracting cream of S2 preparation and S3 preparation is mentioned into cream and is uniformly mixed, the Chinese medicine composition is made, and prepare
At capsule.
Embodiment 4
A kind of Chinese medicine composition preventing tumor in digestive tract recurrence and transfer, is made: half by the raw material of following parts by weight
Branch lotus 13g, dandelion 15g, semen brassicae 10g, Poria cocos 15g, rhizoma arisaematis 15g, ganoderma lucidum 10g, Herba Andrographitis 15g, tuber of pinellia 9g, ginseng
10g, Radix Astragali 14g, oldenlandia diffusa 2g, Radix Glycyrrhizae 7g；
Above-mentioned Chinese medicine composition is specifically made by following steps:
S1: the raw material of following parts by weight is weighed respectively: a kind of Chinese traditional medicine composition for preventing tumor in digestive tract recurrence and transfer
Object is made by the raw material of following parts by weight: Sculellaria barbata 13g, dandelion 15g, semen brassicae 10g, Poria cocos 15g, rhizoma arisaematis 15g,
Ganoderma lucidum 10g, Herba Andrographitis 15g, tuber of pinellia 9g, ginseng 10g, Radix Astragali 14g, oldenlandia diffusa 2g, Radix Glycyrrhizae 7g；
S2: ganoderma lucidum in S1 and ginseng are crushed respectively, are sieved, and hybrid particles are made in mixing；Add in the hybrid particles
Enter the ethyl alcohol that mass fraction is 90% to be impregnated, dip time 20h obtains leaching liquor；It is opposite when leaching liquor is concentrated into 75 DEG C
The alcohol extracting cream that density is 1.25；The ethanol consumption is 2 times of the granular mass；
S3: by Sculellaria barbata, dandelion, semen brassicae, Poria cocos, rhizoma arisaematis, Herba Andrographitis, the tuber of pinellia, Radix Astragali, oldenlandia in S1
Grass, Radix Glycyrrhizae mixing, obtain mixed raw material；The water of 8 times of the mixed raw material quality is added for the first time, decocts 6h, obtain the first filtrate and
First filter residue；It takes the first filter residue that 5 times of water of mixed raw material quality are added, decocts 4h；Obtain the second filtrate and the second filter residue；Take second
2 times of water of mixed raw material quality are added in filter residue, decoct 2h, obtain third filtrate；Merge the first filtrate, the second filtrate and third filter
Liquid, the water that relative density is 1.2 when being concentrated into 65 DEG C mention cream；
S4: the water of the alcohol extracting cream of S2 preparation and S3 preparation is mentioned into cream and is uniformly mixed, the Chinese medicine composition is made, and prepare
At capsule.
We detect the toxicity of Chinese medicine composition prepared in the above embodiments by toxicity test below, pass through clinical treatment
Data illustrate effect of the traditional chinese medicine composition of the invention in terms of the recurrence of prevention tumor in digestive tract and transfer.
Pharmacological toxicity test
1, drug accumulation toxicity test
Method: BALB/c nude mice 40 are taken, female, fifty-fifty, the 18~20g of weight of hero, by Chinese Academy of Medical Sciences experimental animal
Research institute provides.Preposition animal is tested in indoor adaptation environment 3 days, 18~25 DEG C of room temperature, relative humidity 45~65%.It fills daily
The Chinese medicine composition of stomach the above embodiment of the present invention 1~4 is primary, starts given low 2.5g/kgbw, relative to adult clinical
Consumption per day 100 times (quantity be 60kg adult 2 times a day, each 0.75g), later press regular ascending-dose method, gradually
The dosage for increasing daily stomach-filling, makes up to 25g/kgbw, relative to 1000 times of adult clinical daily dosage, continuous 30 days.
It weighs within every 5 days primary.
Testing result: above-mentioned all animals normally survive, and the no phenomena of mortality occur, and have no apparent toxic reaction；
Detect the organs such as the heart, liver lung, kidney, adrenal gland, the results showed that there is no obvious lesions for above-mentioned organ.
2, acute toxicity test
Method: BALB/c nude mice 40 are taken, female, fifty-fifty, the 18~20g of weight of hero, by Chinese Academy of Medical Sciences experimental animal
Research institute provides.Preposition animal is tested in indoor adaptation environment 3 days, 18~25 DEG C of room temperature, relative humidity 45~65%.With adult
500 times of clinical consumption per day give the Chinese medicine composition (before stomach-filling, being mixed well with water) of nude mice stomach-filling above-described embodiment 1~4 once, i.e.,
Observation reaction of animals situation, poisoning symptom and death condition are carved, is observed continuously 7.
Observation result: all animals are strong to deposit, activity freely, drinking-water of ingesting, hair, excreta it is no abnormal, have no
Toxic reaction.
In conclusion by said medicine cumulative toxicity test and the acute toxicity tests it can be proved that system of the present invention
Standby Chinese medicine composition safety is good, and toxicity is low.
Clinical test
1, general information
Using the method for clinical experimental study, selection 01 month -2018 years 03 month 2017 in Gastroenterology dept., institute of traditional Chinese medicine, Henan Province
The tumor in digestive tract of outpatient service and hospitalization suffers from 100 clinical observations, is the patient for voluntarily receiving this test, wherein male
35, female 65, the age 45-65 years old, average (52.3 ± 1.4) year；Cancer of the esophagus 40, colorectal cancer 20,40 Cases of Gastric Cancer.
1.1 are included in standard
A) gastric cancer, colorectal cancer, cancer of the esophagus are diagnosed as according to " newly organized common cancer diagnosis and treatment are advised ".
B) clinical stages, is by II~III phase patient in International Union Against Cancer (UICC) the 5th edition staging scale in 1997.
1.2 exclusion criteria
A) it does not meet and is included in standard person；
B) with uppity nerve, mental disease or phrenoblabia, compliance is poor, and it is anti-not to be able to cooperate and describe treatment
Ying Zhe, primary brain tumor or the nervous centralis metastatic tumor state of an illness do not obtain control, have apparent intracranial hypertension disease or neuropsychic symptom
Person；
C) there is serious acute infection, and do not controlled；Or have suppurative and chronic infection, wound protracted course of disease
Person；
D) pregnant woman, breast feeding women, mental patient；
E) allergic constitution, have drug allergy history or to trial drug allergy sufferers；
F) there is other malignant tumours (curing outside rodent ulcer and carcinoma in-situ of cervix) in 5 years；
G) other medicines experimenter is being participated in.
2, treatment method
1~4 group for the treatment of group, 1~4 group of patient for the treatment of take Chinese medicinal capsule made from Examples 1 to 4 respectively, and 1 day 3 times, often
Secondary two (0.8g), one month is 1 course for the treatment of, and treatment time is 3 courses for the treatment of, while giving less salt low fat bland diet.
3, the standard of curative effect evaluation
The evaluation of 3.1 clinical symptom remission situations
It is evaluated according to the criterion of therapeutical effect of digestive tract tumor treatment in " newly organized common cancer diagnosis and treatment specification ".
Complete incidence graph (CR): lesion completely disappears and the time is more than 4 weeks for CR；
Alleviate (PR) in part: lesion maximum major diameter and maximum perpendicular diameter are significantly lower than before treatment and are reduced after being multiplied after treatment
Degree is more than 50%, other lesions are unchanged, and it is PR that no new lesion time of occurrence, which is more than 4 weeks,；
Stablize (SD): reducing degree less than 50% after lesion maximum major diameter and the multiplication of maximum perpendicular diameter, it is insufficient to increase degree
25%, it is SD that no new lesion time of occurrence, which is more than 4 weeks,；
Progress (PD): lesion maximum major diameter and maximum perpendicular diameter be multiplied after with increase obvious before treatment and degree exists
25% or more or to have new lesion to occur be PD；
Total effective=CR+PR.
3.2 observation of curative effect
All cases are drawn blood before and after taking the traditional chinese medicine composition of the invention detects Immune Index.
3.3 statistical method
Data are handled using 17.0 data software of SPSS, measurement data is indicated with (x ± s), is compared and is examined using t, is counted
Data is indicated with rate (%), is compared using x2It examines, indicates that difference is statistically significant with P < 0.05.
4, result
The comparison of the pretherapy and post-treatment T lymphocyte subgroup of 1 patient of table
By 1 testing result of table it is found that NK cell activity, CD after 1~4 group for the treatment of of treatment group4+、CD4+/CD8+Before treatment
Compare equal apparent increase, there is significant difference；Illustrate that Chinese medicine composition of the invention can improve the immunity of patient.
2 clinical efficacy statistical data of table
By above-mentioned 2 efficacy result of table it is found that the patient's total effective rate for taking the traditional chinese medicine composition of the invention is more than 50%, and
In 52%~60% range, it may be said that bright Chinese medicine composition provided by the invention can effectively prevent the recurrence of tumor in digestive tract
And transfer.
In conclusion the present invention is from tumor in digestive tract pathogenesis, using the raw material of different properties, compatibility science is closed
Reason, above-mentioned all medicines share are capable of the dynamic equilibrium of conditioning engine body, improve immunity of organisms, effectively restore gastral normal
Physiological function achievees the purpose that the relapse and metastasis for preventing tumor in digestive tract.
Obviously, various changes and modifications can be made to the invention without departing from essence of the invention by those skilled in the art
Mind and range.In this way, if these modifications and changes of the present invention belongs to the range of the claims in the present invention and its equivalent technologies
Within be also intended to include these modifications and variations.
Claims (6)
1. a kind of Chinese medicine composition for preventing tumor in digestive tract recurrence and transfer, which is characterized in that by the original of following parts by weight
Material be made: 5~13 parts of Sculellaria barbata, 10~15 parts of dandelion, 3~10 parts of semen brassicae, 8~15 parts of Poria cocos, 9~15 parts of rhizoma arisaematis,
5~10 parts of ganoderma lucidum, 10~15 parts of Herba Andrographitis, 3~9 parts of the tuber of pinellia, 6~10 parts of ginseng, 10~14 parts of Radix Astragali, oldenlandia diffusa 0.5
~2 parts, 1.5~7 parts of Radix Glycyrrhizae.
2. it is according to claim 1 prevention tumor in digestive tract recurrence and transfer Chinese medicine composition, which is characterized in that by with
The raw material of lower parts by weight is made: 8 parts of Sculellaria barbata, 12 parts of dandelion, 6 parts of semen brassicae, 9 parts of Poria cocos, 10 parts of rhizoma arisaematis, ganoderma lucidum 8
Part, 13 parts of Herba Andrographitis, 5 parts of the tuber of pinellia, 8 parts of ginseng, 12 parts of Radix Astragali, 1 part of oldenlandia diffusa, 5 parts of Radix Glycyrrhizae.
3. the preparation method of the Chinese medicine composition of prevention tumor in digestive tract recurrence according to claim 1 or 2 and transfer,
It is characterized in that, comprising the following steps:
S1: weigh the raw material of following parts by weight respectively: 5~13 parts of Sculellaria barbata, 10~15 parts of dandelion, 3~10 parts of semen brassicae,
8~15 parts of Poria cocos, 9~15 parts of rhizoma arisaematis, 5~10 parts of ganoderma lucidum, 10~15 parts of Herba Andrographitis, 3~9 parts of the tuber of pinellia, 6~10 parts of ginseng,
10~14 parts of Radix Astragali, 0.5~2 part of oldenlandia diffusa, 1.5~7 parts of Radix Glycyrrhizae；
S2: ganoderma lucidum in S1 and ginseng are crushed respectively, are sieved, and hybrid particles are made in mixing；Second is added in the hybrid particles
Alcohol prepares alcohol extracting cream；
S3: by Sculellaria barbata in S1, dandelion, semen brassicae, Poria cocos, rhizoma arisaematis, Herba Andrographitis, the tuber of pinellia, Radix Astragali, oldenlandia diffusa, sweet
Grass mixing, obtains mixed raw material；In mixed raw material plus water prepares water and mentions cream；
S4: the water of the alcohol extracting cream of S2 preparation and S3 preparation is mentioned into cream and is uniformly mixed, the Chinese medicine composition is made.
4. the preparation method of the Chinese medicine composition of prevention tumor in digestive tract recurrence according to claim 3 and transfer, special
Sign is, the specific preparation step of alcohol extracting cream in the S2 are as follows:
Ganoderma lucidum in S1 and ginseng are crushed respectively, are sieved, hybrid particles are made in mixing；Quality is added in the hybrid particles
The ethyl alcohol that score is 90% is impregnated, and 15~20h of room temperature immersion obtains leaching liquor；Leaching liquor is concentrated into 65~75 DEG C of phases
The alcohol extracting cream for being 1.2~1.25 to density；The ethanol consumption is 1~2 times of the hybrid particles quality.
5. the preparation method of the Chinese medicine composition of prevention tumor in digestive tract recurrence according to claim 3 and transfer, special
Sign is that water proposes the specific preparation step of cream in the S3 are as follows:
Sculellaria barbata, dandelion, semen brassicae, Poria cocos, rhizoma arisaematis, Herba Andrographitis, the tuber of pinellia, Radix Astragali, oldenlandia diffusa, Radix Glycyrrhizae in S1 are mixed
It closes, obtains mixed raw material；The water of 5~8 times of the mixed raw material quality is added for the first time, decocts 4~6h, obtains the first filtrate and first
Filter residue；It takes the first filter residue that 3~5 times of water of mixed raw material quality are added, decocts 3~4h；Obtain the second filtrate and the second filter residue；Take
1~2 times of water of mixed raw material quality is added in two filter residues, decocts 0.5~2h, obtains third filtrate；Merge the first filtrate, the second filtrate
With third filtrate, the water that relative density is 1.15~1.25 when being concentrated into 65 DEG C mentions cream.
6. the preparation method of the Chinese medicine composition of prevention tumor in digestive tract recurrence according to claim 3 and transfer, special
Sign is that the pharmaceutical dosage form of the Chinese medicine composition is capsule, granule, tablet or pill.
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Application publication date: 20190903 |