CN104666856A - Method for preparing pepsase and trypsase processed wheat taste rehmannia micro-ecological oral solution - Google Patents
Method for preparing pepsase and trypsase processed wheat taste rehmannia micro-ecological oral solution Download PDFInfo
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- CN104666856A CN104666856A CN201310633186.XA CN201310633186A CN104666856A CN 104666856 A CN104666856 A CN 104666856A CN 201310633186 A CN201310633186 A CN 201310633186A CN 104666856 A CN104666856 A CN 104666856A
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Abstract
The invention relates to a method for preparing a pepsase processed wheat taste rehmannia oral solution. The method comprises the following steps: (1) after smashing the wheat taste rehmannia pill raw material, adding water, mixing uniformly to obtain the raw material seriflux; (2) adding an acid into the raw material seriflux to adjust the pH value, adding the pepsase to process to obtain the pepsase processed seriflux; (3) adding the trypsase into the pepsase processed seriflux, processing to obtain the pepsase and trypsase processed seriflux; (4) inoculating the activated bifidobacterium to obtain the pepsase and trypsase processed wheat taste rehmannia micro-ecological oral solution. The pepsase and trypsase processed wheat taste rehmannia micro-ecological oral solution is few in side effect and sweet and sour in taste. The practical application shows that the treatment effect of the wheat taste rehmannia pill can be reached and the side effect of stomach cold and digest obstruction can be greatly reduced after taking the pepsase and trypsase processed wheat taste rehmannia micro-ecological oral solution for a long time.
Description
Technical field
The present invention relates to the preparation method of Maiwei-dihuang micro-ecological oral tonic of a kind of stomach, trypsin treatment, particularly a kind of method utilizing the classical MAIWEIDIHUANGWAN prescription of biotechnology process, belongs to biomedicine technical field.
Background technology
MAIWEIDIHUANGWAN is a kind of conventional Chinese patent medicine, represented by nourishing YIN classics that prescription LIUWEI DIHUANG WAN (Radix Rehmanniae Preparata Fructus Corni Rhizoma Dioscoreae Rhizoma Alismatis Cortex Moutan and Poria) adds Radix Ophiopogonis, Fructus Schisandrae Chinensis forms, Radix Ophiopogonis can support lung yin clearly, there is antipyretic relieving restlessness, nourish strong, lubricate antiinflammatory, control cough with dyspnea, town is told, quench the thirst, stop blooding, lactogenic, diuresis and control the effects such as lingering pathogenic wind arthralgia chiefly caused by damp pathogen; Fructus Schisandrae Chinensis can not only be astringed the lung in nourishing kidney, and the modern general cranial nerve illness such as dizziness, dim eyesight, headache, insomnia that is used for also achieves good curative effect.This medicine comparatively LIUWEI DIHUANG WAN increases the merit of YIN nourishing and the production of body fluid promoting, is effective patent medicine for the treatment of YIN-deficiency of the lung and kidney, cough dyspnea due to deficiency.
But because MAIWEIDIHUANGWAN belongs to sweet warm nature, the relatively medicine of nourishing YIN, cure mainly YIN-deficiency of the lung and kidney, in its formula, cloudy soft medicine is more, so sometimes can antidigestive side effect after eating, therefore not only spleen and stomach function is weak, dyspepsia person is careful eats, and long-term taking can cause the malaise symptoms such as abdominal distention, loose stool, inappetence.
Chinese patent literature CN102225152A(application number 201110171874.X) disclose a kind of preparation method of MAIWEI DIHUANG KOUFU ZHIJI, calculate according to composition by weight, it is prepared from by the following method by Radix Ophiopogonis 30 ~ 120, Fructus Schisandrae (processed) 20 ~ 80, Radix Rehmanniae Preparata 80 ~ 320, Fructus Corni (processed) 40 ~ 160, Cortex Moutan 30 ~ 120, Rhizoma Dioscoreae 40 ~ 160, Poria 30 ~ 120, Rhizoma Alismatis 30 ~ 120 and adjuvant: Radix Ophiopogonis powder is broken into 80 object fine powders, and Cortex Moutan is ground into 80 object fine powders below 60 DEG C and 60 DEG C; Fructus Corni, Fructus Schisandrae Chinensis and Rhizoma Alismatis add 5 ~ 10 times amount, the ethanol extraction of 50 ~ 85% 1 ~ 3 time, each 1 ~ 5 hour, filter, merge extractive liquid, reclaim ethanol and are condensed into thick paste; Radix Rehmanniae Preparata first uses boiling water lixiviate 3 ~ 8 hours, then adds 5 ~ 10 times amount soak by water 1 ~ 4 time with Rhizoma Dioscoreae, Poria, each 0.5 ~ 3 hour, collecting decoction, and filter, filtrate is condensed into thick paste; Above-mentioned fine powder and thick paste mix, and less than 60 DEG C and 60 DEG C dry, pulverize, then add customary adjuvant and conventionally can make different oral formulations.In above-mentioned patent, the antidigestive side effect of MAIWEIDIHUANGWAN does not weaken.
Bacillus bifidus Bifidobacterium is the Gram-positive bacillus by French scholar Tissier isolated a kind of anaerobism from the feces of breast milk nutrition youngster in 1899, and end is bifurcated usually, therefore named bacillus bifidus.Bacillus bifidus has following therapeutic effect: 1, safeguard intestinal normal bacteria colony balance, suppresses the growth of pathogen, prevents constipation, dysentery and gastrointestinal disorders etc.; 2, antitumor; 3, in intestinal synthetic vitamin, aminoacid and raising body to the absorption of calcium ion; 4, reduce Blood Cholesterol level, prevent and treat hypertension; 5, improve the tolerate lactose of milk product, improve digestibility; 6, strengthen human immunologic function, prevent antibiotic side effect, defying age, life lengthening.
Summary of the invention
The present invention is directed to the deficiencies in the prior art, the preparation method of the Maiwei-dihuang micro-ecological oral tonic of a kind of stomach, trypsin treatment is provided.
Term explanation
Pepsic unit of activity (U): adopt the unit of activity that the detection method of Chinese Pharmacopoeia version formulation in 1977 detects.
Tryptic unit of activity (U): the unit of activity that the detection method adopting Chinese Pharmacopoeia nineteen ninety version to formulate detects.
Technical solution of the present invention is as follows:
A preparation method for the Maiwei-dihuang micro-ecological oral tonic of stomach, trypsin treatment, step is as follows:
(1) by eight taste crude drug in MAIWEIDIHUANGWAN raw material after crushed, obtained material powder, then adds 200 ~ 600 grams of water and refined honey by every hectogram material powder, mix homogeneously, obtained raw slurry;
(2) in the obtained raw slurry of step (1), adding sour adjust pH is 1.5 ~ 2.2, add the pepsin of 20 ~ 60 unit of activity by every hectogram MAIWEIDIHUANGWAN raw material, temperature 36 ~ 38 DEG C, process 2 ~ 3 hours, adjusting PH with base value is 7.8 ~ 8.2, the serosity of obtained pepsin;
(3) in the serosity of the obtained pepsin of step (2), add the trypsin of 20 ~ 50 unit of activity by every hundred milliliters, temperature 36 ~ 38 DEG C, process 2 ~ 3 hours, sour adjust pH to 5.5 ~ 6, obtain the serosity of stomach, trypsin treatment;
(4) in the serosity of the obtained stomach of step (3), trypsin treatment, by the activated bacillus bifidus of every hundred milliliters of inoculation 0.5 ~ 2g, the Maiwei-dihuang micro-ecological oral tonic of obtained stomach, trypsin treatment.
Preferred according to the present invention, the MAIWEIDIHUANGWAN raw material of described step (1) is as follows, is weight portion:
Radix Ophiopogonis 30 ~ 120, Fructus Schisandrae (processed) 20 ~ 80, Radix Rehmanniae Preparata 80 ~ 320, Fructus Corni (processed) 40 ~ 160, Cortex Moutan 30 ~ 120, Rhizoma Dioscoreae 40 ~ 160, Poria 30 ~ 120, Rhizoma Alismatis 30 ~ 120, refined honey 7 ~ 22 parts.
Preferred further, the MAIWEIDIHUANGWAN raw material of described step (1) is as follows, is weight portion:
Radix Ophiopogonis 40 parts, Fructus Schisandrae (processed) 40 parts, Radix Rehmanniae Preparata 160 parts, Fructus Corni (processed) (wine Fructus Corni) 80 parts, Cortex Moutan 60 parts, Rhizoma Dioscoreae 80 parts, 60 parts, Poria, Rhizoma Alismatis 60 parts, refined honey 7 ~ 10 parts.
Preferred further, the MAIWEIDIHUANGWAN raw material of described step (1) is as follows, is weight portion:
Radix Ophiopogonis 40 parts, Fructus Schisandrae (processed) 40 parts, Radix Rehmanniae Preparata 160 parts, Fructus Corni (processed) (wine Fructus Corni) 80 parts, Cortex Moutan 60 parts, Rhizoma Dioscoreae 80 parts, 60 parts, Poria, Rhizoma Alismatis 60 parts, refined honey 16 ~ 22 parts.
Preferred according to the present invention, the acid in described step (2), (3) is hydrochloric acid.
Preferred according to the present invention, the alkali of described step (1) is sodium carbonate.
Preferred according to the present invention, in described step (4), activated bacillus bifidus refers to and is inoculated in TPY fluid medium by bacillus bifidus, is cultured to the bacillus bifidus of exponential phase at 36 ~ 38 DEG C.
Preferred further according to the present invention, it is as follows that described TPY fluid medium often rises component:
Peptone 15.0g, yeast powder 2.0g, glucose 20.0g, soluble starch 0.5g, sodium chloride 5.0g, 5wt% cysteine solution 10.0mL, Fructus Lycopersici esculenti leachate 400.0mL, Tween 80 1.0g, liver extracting solution 80.0mL, distilled water 520.0mL, pH7.0.
Described Fructus Lycopersici esculenti leachate be prepared as this area conventional method, step is as follows:
New fresh tomato is cleaned chopping after weighing, add equivalent distilled water and heat in 100 DEG C of water-baths, stir 90min, then use filtered through gauze, adjust pH7.0.
Described liver extracting solution be prepared as this area conventional method, step is as follows:
Take fresh liver 1000g, be cut into small pieces or rub, adding distil water is to 2000mL, and mixing, puts refrigerator overnight, within second day, boil 15min, and filtered through gauze also extrudes collection filtrate, adds water and is settled to 2000mL.
Described bacillus bifidus is beneficial bacteria of intestinal tract, those skilled in the art can select as required, as the bacillus bifidus that the culture presevation in Chinese patent literature CN102946891A number is NCIMB41676, the culture presevation number in Chinese patent literature CN101679938A is the bifidobacterium longum etc. of NCIMB41387.
Beneficial effect
The present invention passes through traditional MAIWEIDIHUANGWAN raw material through stomach, trypsin resolution process, obtain the Maiwei-dihuang micro-ecological oral tonic of the less stomach of side effect, trypsin treatment, this product sour and sweet palatability, and through practical application, this Maiwei rehmannia-root oral liquid of long-term taking can not only reach takes MAIWEIDIHUANGWAN therapeutic effect, and cause cold syndrome of the stomach, hinder digestion side effect also reduced greatly.
Detailed description of the invention
Below in conjunction with embodiment, technical scheme of the present invention is described further, but institute of the present invention protection domain is not limited thereto.
It is as follows that TPY fluid medium in embodiment often rises component:
Peptone 15.0g, yeast powder 2.0g, glucose 20.0g, soluble starch 0.5g, sodium chloride 5.0g, 5wt% cysteine solution 10.0mL, Fructus Lycopersici esculenti leachate 400.0mL, Tween 80 1.0g, liver extracting solution 80.0mL, distilled water 520.0mL, pH7.0;
The preparation process of described Fructus Lycopersici esculenti leachate is as follows:
New fresh tomato is cleaned chopping after weighing, add equivalent distilled water and heat in 100 DEG C of water-baths, stir 90min, then use filtered through gauze, adjust pH7.0;
The preparation process of described liver extracting solution is as follows:
Take fresh liver 1000g, be cut into small pieces or rub, adding distil water is to 2000mL, and mixing, puts refrigerator overnight, within second day, boil 15min, and filtered through gauze also extrudes collection filtrate, adds water and is settled to 2000mL.
Embodiment 1
A preparation method for the Maiwei-dihuang micro-ecological oral tonic of stomach, trypsin treatment, step is as follows:
(1) by eight taste crude drug in MAIWEIDIHUANGWAN raw material after crushed, obtained material powder, then adds 200 grams of water and refined honey by every hectogram material powder, mix homogeneously, obtained raw slurry;
(2) in the obtained raw slurry of step (1), adding hydrochloric acid adjust pH is 1.5, add the pepsin of 20 unit of activity by every hectogram MAIWEIDIHUANGWAN raw material, temperature 36 DEG C, process 3 hours, sodium carbonate adjust pH is 8, the serosity of obtained pepsin;
(3) in the serosity of the obtained pepsin of step (2), add the trypsin of 50 unit of activity by every hundred milliliters, temperature 37 DEG C, process 2 hours, hydrochloric acid adjust pH to 5.5, obtain the serosity of stomach, trypsin treatment;
(4) in the serosity of the obtained stomach of step (3), trypsin treatment, by the activated bacillus bifidus of every hundred milliliters of inoculation 0.5g, the Maiwei-dihuang micro-ecological oral tonic of obtained stomach, trypsin treatment.
The MAIWEIDIHUANGWAN raw material of described step (1) is as follows, is weight portion:
Radix Ophiopogonis 40 parts, Fructus Schisandrae (processed) 40 parts, Radix Rehmanniae Preparata 160 parts, Fructus Corni (processed) (wine Fructus Corni) 80 parts, Cortex Moutan 60 parts, Rhizoma Dioscoreae 80 parts, 60 parts, Poria, Rhizoma Alismatis 60 parts, refined honey 7 parts.
Embodiment 2
A preparation method for the Maiwei-dihuang micro-ecological oral tonic of stomach, trypsin treatment, step is as follows:
(1) by eight taste crude drug in MAIWEIDIHUANGWAN raw material after crushed, obtained material powder, then adds 600 grams of water and refined honey by every hectogram material powder, mix homogeneously, obtained raw slurry;
(2) in the obtained raw slurry of step (1), adding sour adjust pH is 2.2, add the pepsin of 60 unit of activity by every hectogram MAIWEIDIHUANGWAN raw material, temperature 38 DEG C, process 2 hours, sodium carbonate adjust pH is 7.8, the serosity of obtained pepsin;
(3) in the serosity of the obtained pepsin of step (2), add the trypsin of 20 unit of activity by every hundred milliliters, temperature 37 DEG C, process 3 hours, hydrochloric acid adjust pH to 6, obtain the serosity of stomach, trypsin treatment;
(4) in the serosity of the obtained stomach of step (3), trypsin treatment, by the activated bacillus bifidus of every hundred milliliters of inoculation 2g, the Maiwei-dihuang micro-ecological oral tonic of obtained stomach, trypsin treatment.
The MAIWEIDIHUANGWAN raw material of described step (1) is as follows, is weight portion:
Radix Ophiopogonis 40 parts, Fructus Schisandrae (processed) 40 parts, Radix Rehmanniae Preparata 160 parts, Fructus Corni (processed) (wine Fructus Corni) 80 parts, Cortex Moutan 60 parts, Rhizoma Dioscoreae 80 parts, 60 parts, Poria, Rhizoma Alismatis 60 parts, refined honey 22 parts.
Test example 1
History, man, people from Lixia District, Jinan, deficiency of YIN of both the lung and kidney, hectic fever night sweat, dry pharynx, vertigo and tinnitus, spleen and stomach function is normal.Take the Maiwei-dihuang micro-ecological oral tonic of the stomach described in embodiment 1, trypsin treatment, every day secondary, each 15 grams, take one month, symptom is obviously improved, and spleen and stomach function is normal.
Money, man, people from Shizhong District, Jinan, long-term taking MAIWEIDIHUANGWAN causes the symptom of cold syndrome of the stomach, abdominal distention, loose stool, inappetence.Take the Maiwei-dihuang micro-ecological oral tonic of the stomach described in embodiment 1, trypsin treatment, every day secondary, each 15 grams, take one month, the symptom of cold syndrome of the stomach, abdominal distention, loose stool, inappetence alleviates gradually.
Test example 2
Have through 50 the Maiwei-dihuang micro-ecological oral tonic that remarkable deficiency of the kidney yin patient takes stomach, trypsin treatment described in embodiment 2, every day takes twice, each 35 can, take one month, be designated as group 1.Simultaneously 50 have remarkable deficiency of the kidney yin patient and take common commercially available MAIWEIDIHUANGWAN, and by specification is taken, and is designated as group 2.Result is as shown in table 1.
Table 1
| YIN-deficiency of the lung and kidney symptom is improved (people) | Deficiency and coldness of spleen and stomach symptom (people) | |
| Group 1 | 47 | 0 |
| Group 2 | 49 | 20 |
Interpretation of result
As can be seen from Table 1, group 1 and group 2 all obviously can improve the symptom of YIN-deficiency of the lung and kidney patient, but existing commercially available MAIWEIDIHUANGWAN can cause part to take the symptom that patient produces cold syndrome of the stomach, abdominal distention, loose stool, inappetence, and taking the Maiwei-dihuang micro-ecological oral tonic of stomach described in embodiment 2, trypsin treatment, the patient that takes producing above-mentioned symptom obviously reduces.
Claims (8)
1. a preparation method for the Maiwei-dihuang micro-ecological oral tonic of stomach, trypsin treatment, it is characterized in that, step is as follows:
(1) by eight taste crude drug in MAIWEIDIHUANGWAN raw material after crushed, obtained material powder, then adds 200 ~ 600 grams of water and refined honey by every hectogram material powder, mix homogeneously, obtained raw slurry;
(2) in the obtained raw slurry of step (1), adding sour adjust pH is 1.5 ~ 2.2, add the pepsin of 20 ~ 60 unit of activity by every hectogram MAIWEIDIHUANGWAN raw material, temperature 36 ~ 38 DEG C, process 2 ~ 3 hours, adjusting PH with base value is 7.8 ~ 8.2, the serosity of obtained pepsin;
(3) in the serosity of the obtained pepsin of step (2), add the trypsin of 20 ~ 50 unit of activity by every hundred milliliters, temperature 36 ~ 38 DEG C, process 2 ~ 3 hours, sour adjust pH to 5.5 ~ 6, obtain the serosity of stomach, trypsin treatment;
(4) in the serosity of the obtained stomach of step (3), trypsin treatment, by the activated bacillus bifidus of every hundred milliliters of inoculation 0.5 ~ 2g, the Maiwei-dihuang micro-ecological oral tonic of obtained stomach, trypsin treatment.
2. preparation method as claimed in claim 1, it is characterized in that, the MAIWEIDIHUANGWAN raw material of described step (1) is as follows, is weight portion:
Radix Ophiopogonis 30 ~ 120, Fructus Schisandrae (processed) 20 ~ 80, Radix Rehmanniae Preparata 80 ~ 320, Fructus Corni (processed) 40 ~ 160, Cortex Moutan 30 ~ 120, Rhizoma Dioscoreae 40 ~ 160, Poria 30 ~ 120, Rhizoma Alismatis 30 ~ 120, refined honey 7 ~ 22 parts.
3. preparation method as claimed in claim 2, it is characterized in that, the MAIWEIDIHUANGWAN raw material of described step (1) is as follows, is weight portion:
Radix Ophiopogonis 40 parts, Fructus Schisandrae (processed) 40 parts, Radix Rehmanniae Preparata 160 parts, Fructus Corni (processed) (wine Fructus Corni) 80 parts, Cortex Moutan 60 parts, Rhizoma Dioscoreae 80 parts, 60 parts, Poria, Rhizoma Alismatis 60 parts, refined honey 7 ~ 10 parts.
4. preparation method as claimed in claim 2, it is characterized in that, the MAIWEIDIHUANGWAN raw material of described step (1) is as follows, is weight portion:
Radix Ophiopogonis 40 parts, Fructus Schisandrae (processed) 40 parts, Radix Rehmanniae Preparata 160 parts, Fructus Corni (processed) (wine Fructus Corni) 80 parts, Cortex Moutan 60 parts, Rhizoma Dioscoreae 80 parts, 60 parts, Poria, Rhizoma Alismatis 60 parts, refined honey 16 ~ 22 parts.
5. preparation method as claimed in claim 1, it is characterized in that, the acid in described step (2), (3) is hydrochloric acid.
6. preparation method as claimed in claim 1, it is characterized in that, the alkali of described step (1) is sodium carbonate.
7. preparation method as claimed in claim 1, it is characterized in that, in described step (4), activated bacillus bifidus refers to and is inoculated in TPY fluid medium by bacillus bifidus, is cultured to the bacillus bifidus of exponential phase at 36 ~ 38 DEG C.
8. preparation method as claimed in claim 7, it is characterized in that, it is as follows that described TPY fluid medium often rises component:
Peptone 15.0g, yeast powder 2.0g, glucose 20.0g, soluble starch 0.5g, sodium chloride 5.0g, 5wt% cysteine solution 10.0mL, Fructus Lycopersici esculenti leachate 400.0mL, Tween 80 1.0g, liver extracting solution 80.0mL, distilled water 520.0mL, pH7.0.
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| CN201310633186.XA CN104666856A (en) | 2013-11-30 | 2013-11-30 | Method for preparing pepsase and trypsase processed wheat taste rehmannia micro-ecological oral solution |
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| CN201310633186.XA CN104666856A (en) | 2013-11-30 | 2013-11-30 | Method for preparing pepsase and trypsase processed wheat taste rehmannia micro-ecological oral solution |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101129413A (en) * | 2007-08-25 | 2008-02-27 | 丁林权 | Polyzyme emulsifying method of traditional Chinese medicine |
| CN102225152A (en) * | 2011-06-23 | 2011-10-26 | 贵州弘康药业有限公司 | Preparation method of Maiwei rehmannia oral preparation |
-
2013
- 2013-11-30 CN CN201310633186.XA patent/CN104666856A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101129413A (en) * | 2007-08-25 | 2008-02-27 | 丁林权 | Polyzyme emulsifying method of traditional Chinese medicine |
| CN102225152A (en) * | 2011-06-23 | 2011-10-26 | 贵州弘康药业有限公司 | Preparation method of Maiwei rehmannia oral preparation |
Non-Patent Citations (2)
| Title |
|---|
| 国家药典委员会: "《中华人民共和国药典 2010年版 一部》", 31 January 2010 * |
| 黄叶: "试论微生态中药制剂——开发策略与战略意义", 《中国药业》 * |
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