CN105535065A - Medicine composition for treating schizophrenia - Google Patents
Medicine composition for treating schizophrenia Download PDFInfo
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/30—Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
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- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
Abstract
The invention discloses a medicine composition for treating schizophrenia and a preparing method of the medicine composition. The medicine composition is prepared from bumalda bladdernut fruits or roots, whole grass of thyrocarpus sampsonii hance, crotepoxide and corlumine according to a proportion. The medicine composition can be prepared into various dosage forms according to conventional preparation technologies, and is significant in treatment effect when used for treating schizophrenia.
Description
Technical field
The invention belongs to technical field of Chinese medicines, particularly relate to one and treat schizoid pharmaceutical composition and preparation method thereof.
Background technology
Schizophrenia belongs to the category of the insane disease of motherland's medical science, mad disease, and its sick position is at refreshing machine, and the pathogenesis key of insane disease is that visceral-qi is uneven, imbalance of YIN and YANG, and refreshing machine is disorderly inverse.To regulate the flow of vital energy resolving depression, fluent refreshing machine, easy property of shifting one's love is its principle for the treatment of; The pathogenesis of mad disease is the inaccessible thinking of phlegm-fire blood stasis, and imbalance of YIN and YANG, body and the spirit is out of control.Regulating YIN and YANG, recovers the method that refreshing machine effects a permanent cure for it.Modern medicine is thought, schizophrenia is the not bright mental sickness of one group of cause of disease, and its Clinical typing is rather detailed, treatment development is very fast, especially in control acute symptom, demonstrate obvious advantage, but most distinct issues are difficult to solve recurrence trend, the result repeatedly recurred is mental deterioration.Negative symptoms of schizophrenia has a strong impact on social function and the rehabilitation of patient, is the difficult point for the treatment of of schizophrenia and the focus of Recent study always.Although antipsychotic agent has some improvement to negative symptoms of schizophrenia, the degree improved fundamentally can not meet the requirement of patient's Social Disability.
Fructus Staphyleae Bumaldae: this product is Palmae Daemonorops plant Caulis Fibraureae Daemonoropsmargaritae(Hance) Becc. [CalamusmargaritaeHance ］ stem.The whole year all can adopt, and cutting is dried.[nature and flavor] bitter in the mouth; Property is put down.[function cures mainly] anthelmintic; Treating stranguria; Wind dispelling pain relieving.Main ascarid; Pinworm; Taeniasis; Urine leaching pain; Toothache.[former phytomorph] Caulis Fibraureae, the large liana of spinosity.Stem is upright at the beginning, after climb up by holding on to shape.Leaf pinniform is totally cleaved, total length 2-3m, and rachis top extends into the fine whip of tool claw-like thorn; Sliver closely to life, 50-75 couple, strip lanceolar, long 25-45cm, wide l-2cm, tip is gradually sharp, and there is the thorn of the lower curved or rigidness that differs in size at the rachis back side; Sheath is without fine whip but have flat thorn.Spadix encloses for spathe before blooming, and in spindle, long 25-30cm, Zhu Duan shape of tail is gradually sharp, and 1 piece, outside is close by brown, flat straight thrust, and the spathe of the inside stings or stingless less, and after yielding positive results, spathe comes off.Rachilla on staminate inflorescence is intensive, is about 3cm, spends intensive, and the oval shape of male flower is avette, long 5mm; Calyx cup-shaped, shallow 3 teeth; Corolla 3 splits, and is longer than calyx for about 2 times; Stamen 6, is about 3.5mm, involucre tazza shape.Female flower: calyx short cylinder shaped, tip 3 fissure; Petal lanceolar, is about 2 times into calyx; Ovary is avette, 3 pieces, stigma.Fruit is spherical, diameter 1.8-2cm, has the scale of the capable file of 18-20, and scale has 10-20 on every 1 row, yellow and bright, has groove stricture of vagina.The seed kidney shape is spherical.May at florescence, the fruit phase 6-10 month.Record in Chinese medicine voluminous dictionary.
Radix Thyrocarpi sampsonii: the herb of Boraginaceae Radix Thyrocarpi sampsonii platymiscium Radix Thyrocarpi sampsonii ThyrocarpussampsoniiHance.4 ~ June adopts herb, dries.[nature and flavor] are bitter; Cool.[return through] heart; Large intestine channel.[function cures mainly] clearing heat, releasing toxin, removing swelling.Main carbuncle; Furuncle; Have sore throat; Have loose bowels; Dysentery.[character] stem is comparatively thin, and 1 to several, cylindrical, long 10-30cm, surperficial withered green, the rough hair of tool canescence, the crisp frangibility of matter, section white.Basal leaf is grown thickly, and shrinkage is curling, and after moistening expansion, cochlear, tool handle, long 3.5-19cm, wide 1-5cm, withered green or bottle green, two sides equal tool canescence coarse wool, stem leaf is less, stockless.Blade is slightly thick.Sometimes visible blue or purple little Hua.Or having the pyrene of two-layer bowl-shape projection, base top exterior layer has upright gear, and internal layer is close to edge.Feeble QI mildly bitter flavor.Record in Chinese medicine voluminous dictionary.
Crotepoxide (Crotepoxide): CAS 20421-13-0, molecular formula C
18h
18o
8, molecular weight 362.34.[pharmacological action] is anticancer.The fruit of the long fringe Fructus Crotonis of [ingredient origin] euphorbia plant, the luxuriant rattan of Piperaceae plant Prunus mume Xi Ye Qing.
Corymine (Corlumine): CAS 485-51-8, molecular formula C
21h
21nO
6, molecular weight 383.40.[pharmacological action] has the effect of excited uterus.[ingredient origin] bloodroot Siberia Herba corydalis edulis CorydalissibiricaPers., Xie Shi Herba corydalis edulis CorydalissewerzowiRegel aerial parts.
2 crude drug chemical constitutions:
Crotepoxide (Crotepoxide) corymine (Corlumine).
Summary of the invention
The object of the invention is the deficiency overcoming background technology, schizoid pharmaceutical composition of a kind of effectively treatment and preparation method thereof is provided.
The present invention adopts following technical scheme to realize:
Composition and the weight portion of making the crude drug of the schizoid pharmaceutical composition of this treatment are:
Fructus Staphyleae Bumaldae 4800-4860 weight portion Radix Thyrocarpi sampsonii 4600-4680 weight portion crotepoxide 180-190 weight portion corymine 190-192 weight portion.
Preferably be used for the treatment of schizoid pharmaceutical composition, be made up of the crude drug of following weight portion:
Fructus Staphyleae Bumaldae 4830 weight portion Radix Thyrocarpi sampsonii 4640 weight portion crotepoxide 185 weight portion corymine 191 weight portion.
One treats schizoid pharmaceutical composition, it is characterized in that pharmaceutical composition can adopt the conventional method of galenic pharmacy to be prepared into tablet or capsule or drop pill.
One treats schizoid pharmaceutical composition, it is characterized in that the treatment schizophrenia drug that pharmaceutical composition and chemical drugs or Chinese medicine form.
Treat a preparation method for schizoid pharmaceutical composition, it is characterized in that preparing as follows:
The composition of crude drug and weight portion are: Fructus Staphyleae Bumaldae 4800-4860 weight portion Radix Thyrocarpi sampsonii 4600-4680 weight portion crotepoxide 180-190 weight portion corymine 190-192 weight portion;
Preparation method:
(1) Fructus Staphyleae Bumaldae is got by crude drug proportioning, Radix Thyrocarpi sampsonii, crotepoxide, corymine, mixing, with weight percent concentration 24% ethanol as solvent, extract at 25.5 DEG C of warm macerating, extraction time is 20 times, each extraction time is 2.5 hours, each solvent load is 38.5 times of crude drug gross weight, filter, obtain medicinal residues A and extracting solution A, extracting solution A reclaims ethanol, be concentrated into relative density 1.16, filter, medicinal liquid is by DM18 macroporous adsorptive resins, first wash with water, use weight percent concentration 42.5% alcoholic solution eluting DM18 macroporous adsorptive resins again, collect weight percent concentration 42.5% ethanol elution, reclaim ethanol, concentrate drying, obtain extract A,
(2) step (1) medicinal residues A is got, with weight percent concentration 42% ethanol as solvent, heating and refluxing extraction 10 times, each extraction time is 0.2 hour, each solvent load is 16 times of medicinal residues A weight, filter, obtain medicinal residues B and extracting solution B, extracting solution B reclaims ethanol, be concentrated into relative density 1.19, filter, medicinal liquid is by DM20 macroporous adsorptive resins, first wash with water, use weight percent concentration 94.5% alcoholic solution eluting DM20 macroporous adsorptive resins again, collect weight percent concentration 94.5% ethanol elution, reclaim ethanol, concentrate drying, obtain extract B,
(3) by extract A and extract B mixing, pharmaceutical composition is obtained.
Preferably treat a preparation method for schizoid pharmaceutical composition, it is characterized in that preparing as follows:
The composition of crude drug and weight portion are: Fructus Staphyleae Bumaldae 4830 weight portion Radix Thyrocarpi sampsonii 4640 weight portion crotepoxide 185 weight portion corymine 191 weight portion;
Preparation method:
(1) Fructus Staphyleae Bumaldae is got by crude drug proportioning, Radix Thyrocarpi sampsonii, crotepoxide, corymine, mixing, with weight percent concentration 24% ethanol as solvent, extract at 25.5 DEG C of warm macerating, extraction time is 20 times, each extraction time is 2.5 hours, each solvent load is 38.5 times of crude drug gross weight, filter, obtain medicinal residues A and extracting solution A, extracting solution A reclaims ethanol, be concentrated into relative density 1.16, filter, medicinal liquid is by DM18 macroporous adsorptive resins, first wash with water, use weight percent concentration 42.5% alcoholic solution eluting DM18 macroporous adsorptive resins again, collect weight percent concentration 42.5% ethanol elution, reclaim ethanol, concentrate drying, obtain extract A,
(2) step (1) medicinal residues A is got, with weight percent concentration 42% ethanol as solvent, heating and refluxing extraction 10 times, each extraction time is 0.2 hour, each solvent load is 16 times of medicinal residues A weight, filter, obtain medicinal residues B and extracting solution B, extracting solution B reclaims ethanol, be concentrated into relative density 1.19, filter, medicinal liquid is by DM20 macroporous adsorptive resins, first wash with water, use weight percent concentration 94.5% alcoholic solution eluting DM20 macroporous adsorptive resins again, collect weight percent concentration 94.5% ethanol elution, reclaim ethanol, concentrate drying, obtain extract B,
(3) by extract A and extract B mixing, pharmaceutical composition is obtained.
Treat a preparation method for schizoid pharmaceutical composition, it is characterized in that pharmaceutical composition can adopt the conventional method of galenic pharmacy to be prepared into tablet or capsule or drop pill.
Treat a preparation method for schizoid pharmaceutical composition, it is characterized in that pharmaceutical composition and chemical drugs or Chinese medicine form and treat schizophrenia drug.
Medicine composite for curing Stability of Schizophrenia is remarkable.
Detailed description of the invention
Embodiment 1: treat schizoid pharmaceutical composition and preparation method thereof
Composition and the weight portion for the treatment of the crude drug of schizoid pharmaceutical composition are: Fructus Staphyleae Bumaldae 4830g Radix Thyrocarpi sampsonii 4640g crotepoxide 185g corymine 191g;
Preparation method:
(1) Fructus Staphyleae Bumaldae is got by crude drug proportioning, Radix Thyrocarpi sampsonii, crotepoxide, corymine, mixing, with weight percent concentration 24% ethanol as solvent, extract at 25.5 DEG C of warm macerating, extraction time is 20 times, each extraction time is 2.5 hours, each solvent load is 38.5 times of crude drug gross weight, filter, obtain medicinal residues A and extracting solution A, extracting solution A reclaims ethanol, be concentrated into relative density 1.16, filter, medicinal liquid is by DM18 macroporous adsorptive resins, first wash with water, use weight percent concentration 42.5% alcoholic solution eluting DM18 macroporous adsorptive resins again, collect weight percent concentration 42.5% ethanol elution, reclaim ethanol, concentrate drying, obtain extract A,
(2) step (1) medicinal residues A is got, with weight percent concentration 42% ethanol as solvent, heating and refluxing extraction 10 times, each extraction time is 0.2 hour, each solvent load is 16 times of medicinal residues A weight, filter, obtain medicinal residues B and extracting solution B, extracting solution B reclaims ethanol, be concentrated into relative density 1.19, filter, medicinal liquid is by DM20 macroporous adsorptive resins, first wash with water, use weight percent concentration 94.5% alcoholic solution eluting DM20 macroporous adsorptive resins again, collect weight percent concentration 94.5% ethanol elution, reclaim ethanol, concentrate drying, obtain extract B,
(3) by extract A and extract B mixing, pharmaceutical composition is obtained.
Embodiment 2: treat schizoid pharmaceutical composition and preparation method thereof
Composition and the weight portion for the treatment of the crude drug of schizoid pharmaceutical composition are: Fructus Staphyleae Bumaldae 4800g Radix Thyrocarpi sampsonii 4680g crotepoxide 180g corymine 192g;
Preparation method:
(1) Fructus Staphyleae Bumaldae is got by crude drug proportioning, Radix Thyrocarpi sampsonii, crotepoxide, corymine, mixing, with weight percent concentration 24% ethanol as solvent, extract at 25.5 DEG C of warm macerating, extraction time is 20 times, each extraction time is 2.5 hours, each solvent load is 38.5 times of crude drug gross weight, filter, obtain medicinal residues A and extracting solution A, extracting solution A reclaims ethanol, be concentrated into relative density 1.16, filter, medicinal liquid is by DM18 macroporous adsorptive resins, first wash with water, use weight percent concentration 42.5% alcoholic solution eluting DM18 macroporous adsorptive resins again, collect weight percent concentration 42.5% ethanol elution, reclaim ethanol, concentrate drying, obtain extract A,
(2) step (1) medicinal residues A is got, with weight percent concentration 42% ethanol as solvent, heating and refluxing extraction 10 times, each extraction time is 0.2 hour, each solvent load is 16 times of medicinal residues A weight, filter, obtain medicinal residues B and extracting solution B, extracting solution B reclaims ethanol, be concentrated into relative density 1.19, filter, medicinal liquid is by DM20 macroporous adsorptive resins, first wash with water, use weight percent concentration 94.5% alcoholic solution eluting DM20 macroporous adsorptive resins again, collect weight percent concentration 94.5% ethanol elution, reclaim ethanol, concentrate drying, obtain extract B,
(3) by extract A and extract B mixing, pharmaceutical composition is obtained.
Embodiment 3: treat schizoid pharmaceutical composition and preparation method thereof
Composition and the weight portion for the treatment of the crude drug of schizoid pharmaceutical composition are: Fructus Staphyleae Bumaldae 4860g Radix Thyrocarpi sampsonii 4600g crotepoxide 190g corymine 190g;
Preparation method:
(1) Fructus Staphyleae Bumaldae is got by crude drug proportioning, Radix Thyrocarpi sampsonii, crotepoxide, corymine, mixing, with weight percent concentration 24% ethanol as solvent, extract at 25.5 DEG C of warm macerating, extraction time is 20 times, each extraction time is 2.5 hours, each solvent load is 38.5 times of crude drug gross weight, filter, obtain medicinal residues A and extracting solution A, extracting solution A reclaims ethanol, be concentrated into relative density 1.16, filter, medicinal liquid is by DM18 macroporous adsorptive resins, first wash with water, use weight percent concentration 42.5% alcoholic solution eluting DM18 macroporous adsorptive resins again, collect weight percent concentration 42.5% ethanol elution, reclaim ethanol, concentrate drying, obtain extract A,
(2) step (1) medicinal residues A is got, with weight percent concentration 42% ethanol as solvent, heating and refluxing extraction 10 times, each extraction time is 0.2 hour, each solvent load is 16 times of medicinal residues A weight, filter, obtain medicinal residues B and extracting solution B, extracting solution B reclaims ethanol, be concentrated into relative density 1.19, filter, medicinal liquid is by DM20 macroporous adsorptive resins, first wash with water, use weight percent concentration 94.5% alcoholic solution eluting DM20 macroporous adsorptive resins again, collect weight percent concentration 94.5% ethanol elution, reclaim ethanol, concentrate drying, obtain extract B,
(3) by extract A and extract B mixing, pharmaceutical composition is obtained.
Embodiment 4: the preparation of tablet
Example 1 pharmaceutical composition 357g, adds starch 162g, mixing, granulates, dry, adds microcrystalline Cellulose 14g, magnesium stearate 2g, and mixing, is pressed into 1000, obtains medicinal composition tablets.
Embodiment 5: the preparation of capsule
Example 2 pharmaceutical composition 318g, adds starch 124g, mixing, granulates, and dry, granulate, adds appropriate magnesium stearate, and mixing, obtains medicament composition capsule by encapsulated 1000.
Embodiment 6: the preparation of drop pill
Taking polyethylene glycol 6000 265g water-bath (80 DEG C) heating boils molten, add embodiment 3 pharmaceutical composition 22g, stirring, is coolant with liquid paraffin, puts in glass tubing (4*80cm), chilling temperature is 2 DEG C, drip internal-and external diameter is 7.0/1.5 (mm/mm), and drip is 1.2cm apart from liquid level, drips speed with per minute 54 for optimum condition, blot the condensing agent on drop pill surface with cotton, obtain medicament composition dropping pills.
Embodiment 7: treat schizoid pharmaceutical composition
Composition and the weight portion for the treatment of the crude drug of schizoid pharmaceutical composition are:
Fructus Staphyleae Bumaldae 4713 weight portion crotepoxide 193 weight portion corymine 163 weight portion.
Embodiment 8: treat schizoid pharmaceutical composition
Composition and the weight portion for the treatment of the crude drug of schizoid pharmaceutical composition are:
Radix Thyrocarpi sampsonii 4710 weight portion crotepoxide 194 weight portion corymine 176 weight portion.
Embodiment 9: treat schizoid pharmaceutical composition
Composition and the weight portion for the treatment of the crude drug of schizoid pharmaceutical composition are:
Fructus Staphyleae Bumaldae 3506 weight portion crotepoxide 165 weight portion corymine 175 weight portion Radix Thyrocarpi sampsonii 3202 weight portion.
Experimental example 1: treatment schizophrenia Experiment on Function research
1 object and method
1.1 object
This group man 27 example, female 7 example, 20 ~ 30 years old 18 age example, 30 ~ 50 years old 16 example.Medicining condition before research: chlorpromazine 7 example, clozapine 5 example, perphenazine 3 example, haloperidol 2 example.Manic disorder 19 example, epilepsy 10 example, demented merging 5 example.
1.2 method
Adopt pharmaceutical composition (embodiment 1 pharmaceutical composition lot number 20110912) treatment, each 1g, 3 times/day 30 days is 1 course for the treatment of, treats 3 courses for the treatment of continuously.
1.3 efficacy assessment standard
Recovery from illness: all diseases disappear, thinking, emotion and the will coordinating and unifying; Effective: outbreak stops, and thinking, emotion and will are sometimes inharmonious; Take a turn for the better: sometimes show effect, thinking, emotion and will are inharmonious; Invalid: all diseases without improvement, the complete inharmonious unification of thinking, emotion and will.
2 results
2.1 total effective rate
The results are shown in Table 1.
Table 1 pharmaceutical composition efficacy result
| Typing | Example | Recovery from illness | Effective | Take a turn for the better | Invalid | Total effective rate % |
| Manic disorder | 19 | 6 | 7 | 4 | 2 | 89.47 |
| Epilepsy | 10 | 4 | 3 | 2 | 1 | 90.00 |
| Demented merging | 5 | 2 | 2 | 1 | 0 | 100 |
| Add up to | 34 | 12 | 12 | 7 | 3 | 91.18 |
By after evaluation 3 courses for the treatment of of effect, recovery from illness 12 example, effective 12 examples, take a turn for the better 7 examples, invalid 3 examples, total effective rate 91.18%.Wherein recovery from illness 6 example in manic disorder 19 example, effective 7 examples, take a turn for the better 4 examples, and invalid 2 is routine, total effective rate 89.47%.Recovery from illness 4 example in epilepsy 10 example, effective 3 examples, take a turn for the better 2 examples, and invalid 1 is routine, total effective rate 90.00%.Recovery from illness 2 example in demented merging 5 example, effective 2 examples, take a turn for the better 1 example, total effective rate 100%.
3 model cases
Example 1: man, 25 years old.Because of failure in love, ponder over immoderate all day, and cause epilepsy, once arrive certain hospital and seek medical advice, be diagnosed as schizophrenia.Hospitalization more than 1 month, symptom, without improvement, after automatically leaving hospital, is come here and is required treatment.See its disease: dim complexion, anxiously, give an irrelevant answer, delusion of relation, delusion of persecution, white and greasy fur, stringy and thready pulse.Clinical examination is every all normal.Tcm diagnosis: epilepsy.Be stagnation of QI due to depression of the liver, stagnation of QI expectorant is raw, disturbs in expectorant heat, covers and closes thinking.Control suitable QI regulating by alleviation of mental depression, waking up the patient from unconsciousness by dissipating phlegm, tranquilizing the mind clears away heart-fire.Adopt pharmaceutical composition (embodiment 1 pharmaceutical composition lot number 20110912) treatment, each 1g, 3 times/day 30 days is 1 course for the treatment of, treats 3 courses for the treatment of continuously.Conscious, spirit takes a favorable turn, and expresses one's feelings self-possessed, just like ordinary person, and obtains recovery from illness.
Example 2: female, 52 years old.Because husband's traffic death causes Mental Subnormality, successively 2 hospitalization.See its disease: not properly dressed, One's eyesight is restrained, time and cry and laugh at, dance for joy, have pseudoacousis, without insight.Red tongue, yellow and greasy fur, slippery and rapid pulse, clinical every inspection is all normal.Tcm diagnosis: mad disease.Be due to irritability stasis, heat-transformation for a long time, blood stasis hinders network heart spirit confused by phlegm and causes.Adopt pharmaceutical composition (embodiment 1 pharmaceutical composition lot number 20110912) treatment, each 1g, 3 times/day 30 days is 1 course for the treatment of, treats 3 courses for the treatment of continuously.Transference cure, takes care of oneself, and insight recovers.
Claims (8)
1. treat a schizoid pharmaceutical composition, it is characterized in that the composition of the crude drug making this pharmaceutical composition and weight portion are:
Fructus Staphyleae Bumaldae 4800-4860 weight portion Radix Thyrocarpi sampsonii 4600-4680 weight portion crotepoxide 180-190 weight portion corymine 190-192 weight portion.
2. one treats schizoid pharmaceutical composition according to claim 1, it is characterized in that the composition of the crude drug making this pharmaceutical composition and weight portion are:
Fructus Staphyleae Bumaldae 4830 weight portion Radix Thyrocarpi sampsonii 4640 weight portion crotepoxide 185 weight portion corymine 191 weight portion.
3. one treats schizoid pharmaceutical composition according to claim 1, it is characterized in that pharmaceutical composition can adopt the conventional method of galenic pharmacy to be prepared into tablet or capsule or drop pill.
4. one treats schizoid pharmaceutical composition according to claim 1, it is characterized in that the treatment schizophrenia drug that pharmaceutical composition and chemical drugs or Chinese medicine form.
5. treat a preparation method for schizoid pharmaceutical composition, it is characterized in that preparing as follows:
The composition of crude drug and weight portion are: Fructus Staphyleae Bumaldae 4800-4860 weight portion Radix Thyrocarpi sampsonii 4600-4680 weight portion crotepoxide 180-190 weight portion corymine 190-192 weight portion;
Preparation method:
(1) Fructus Staphyleae Bumaldae is got by crude drug proportioning, Radix Thyrocarpi sampsonii, crotepoxide, corymine, mixing, with weight percent concentration 24% ethanol as solvent, extract at 25.5 DEG C of warm macerating, extraction time is 20 times, each extraction time is 2.5 hours, each solvent load is 38.5 times of crude drug gross weight, filter, obtain medicinal residues A and extracting solution A, extracting solution A reclaims ethanol, be concentrated into relative density 1.16, filter, medicinal liquid is by DM18 macroporous adsorptive resins, first wash with water, use weight percent concentration 42.5% alcoholic solution eluting DM18 macroporous adsorptive resins again, collect weight percent concentration 42.5% ethanol elution, reclaim ethanol, concentrate drying, obtain extract A,
(2) step (1) medicinal residues A is got, with weight percent concentration 42% ethanol as solvent, heating and refluxing extraction 10 times, each extraction time is 0.2 hour, each solvent load is 16 times of medicinal residues A weight, filter, obtain medicinal residues B and extracting solution B, extracting solution B reclaims ethanol, be concentrated into relative density 1.19, filter, medicinal liquid is by DM20 macroporous adsorptive resins, first wash with water, use weight percent concentration 94.5% alcoholic solution eluting DM20 macroporous adsorptive resins again, collect weight percent concentration 94.5% ethanol elution, reclaim ethanol, concentrate drying, obtain extract B,
(3) by extract A and extract B mixing, pharmaceutical composition is obtained.
6. a kind of preparation method for the treatment of schizoid pharmaceutical composition according to claim 5, is characterized in that preparing as follows:
The composition of crude drug and weight portion are: Fructus Staphyleae Bumaldae 4830 weight portion Radix Thyrocarpi sampsonii 4640 weight portion crotepoxide 185 weight portion corymine 191 weight portion;
Preparation method:
(1) Fructus Staphyleae Bumaldae is got by crude drug proportioning, Radix Thyrocarpi sampsonii, crotepoxide, corymine, mixing, with weight percent concentration 24% ethanol as solvent, extract at 25.5 DEG C of warm macerating, extraction time is 20 times, each extraction time is 2.5 hours, each solvent load is 38.5 times of crude drug gross weight, filter, obtain medicinal residues A and extracting solution A, extracting solution A reclaims ethanol, be concentrated into relative density 1.16, filter, medicinal liquid is by DM18 macroporous adsorptive resins, first wash with water, use weight percent concentration 42.5% alcoholic solution eluting DM18 macroporous adsorptive resins again, collect weight percent concentration 42.5% ethanol elution, reclaim ethanol, concentrate drying, obtain extract A,
(2) step (1) medicinal residues A is got, with weight percent concentration 42% ethanol as solvent, heating and refluxing extraction 10 times, each extraction time is 0.2 hour, each solvent load is 16 times of medicinal residues A weight, filter, obtain medicinal residues B and extracting solution B, extracting solution B reclaims ethanol, be concentrated into relative density 1.19, filter, medicinal liquid is by DM20 macroporous adsorptive resins, first wash with water, use weight percent concentration 94.5% alcoholic solution eluting DM20 macroporous adsorptive resins again, collect weight percent concentration 94.5% ethanol elution, reclaim ethanol, concentrate drying, obtain extract B,
(3) by extract A and extract B mixing, pharmaceutical composition is obtained.
7. a kind of preparation method for the treatment of schizoid pharmaceutical composition according to claim 5, is characterized in that pharmaceutical composition can adopt the conventional method of galenic pharmacy to be prepared into tablet or capsule or drop pill.
8. a kind of preparation method for the treatment of schizoid pharmaceutical composition according to claim 5, is characterized in that pharmaceutical composition and chemical drugs or Chinese medicine form and treats schizophrenia drug.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106581100A (en) * | 2016-12-10 | 2017-04-26 | 济南昊雨青田医药技术有限公司 | Pharmaceutical composition for laryngitis treatment and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106581100A (en) * | 2016-12-10 | 2017-04-26 | 济南昊雨青田医药技术有限公司 | Pharmaceutical composition for laryngitis treatment and preparation method thereof |
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